|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
10-319 |
0e+00 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 517.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 10 PATVLGAMEMG---RRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLrmgsSDCRVKIATKANPWIGNSL 86
Cdd:cd19075 1 PKIILGTMTFGsqgRFTTAEAAAELLDAFLERGHTEIDTARVYPDGTSEELLGELGL----GERGFKIDTKANPGVGGGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 87 KPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPT 166
Cdd:cd19075 77 SPENVRKQLETSLKRLKVDKVDVFYLHAPDRSTPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEICKENGWVLPT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 167 VYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKdgKQPVGRFFG-TQWAEIYRNHFWKEHHFEGI 245
Cdd:cd19075 157 VYQGMYNAITRQVETELFPCLRKLGIRFYAYSPLAGGFLTGKYKYSED--KAGGGRFDPnNALGKLYRDRYWKPSYFEAL 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1139695540 246 ALVEKALQaaygASAPSMTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAW 319
Cdd:cd19075 235 EKVEEAAE----KEGISLAEAALRWLYHHSALDGEKGDGVILGASSLEQLEENLAALEKGPLPEEVVKAIDEAW 304
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
14-319 |
8.47e-71 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 222.75 E-value: 8.47e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMEMGR---RMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLgLRMGSSDcRVKIATKA-----NPWIGNS 85
Cdd:COG0667 18 LGTMTFGGpwgGVDEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEA-LKGRPRD-DVVIATKVgrrmgPGPNGRG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 86 LKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsnGWILP 165
Cdd:COG0667 96 LSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVSNYSAEQLRRALAIAE--GLPPI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 166 TVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYkyeDKDGKQPVGRFFGTQWAEIYRNHfwkehhfEGI 245
Cdd:COG0667 174 VAVQNEYSLLDRSAEEELLPAARELGVGVLAYSPLAGGLLTGKY---RRGATFPEGDRAATNFVQGYLTE-------RNL 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1139695540 246 ALVE--KALQAAYGASAPSMtsaALRWMYHHSQLqgahgDAVILGMSSLEQLEQNLAAAEEgPLEPAVVDAFNQAW 319
Cdd:COG0667 244 ALVDalRAIAAEHGVTPAQL---ALAWLLAQPGV-----TSVIPGARSPEQLEENLAAADL-ELSAEDLAALDAAL 310
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
10-300 |
3.70e-64 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 202.75 E-value: 3.70e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 10 PATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLglrMGSSDCR--VKIATKA-----NPWI 82
Cdd:cd06660 1 SRLGLGTMTFGGDGDEEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRW---LKGRGNRddVVIATKGghppgGDPS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 83 GNSLKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGW 162
Cdd:cd06660 78 RSRLSPEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEETLEALNELVREGKIRYIGVSNWSAERLAEALAYAKAHGL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 163 ILPTVYQGMYS-ATTRQVETELFPCLRHFGLRFYAYNPLAGGLltgkykyedkdgkqpvgrffgtqwaeiyrnhfwkehh 241
Cdd:cd06660 158 PGFAAVQPQYSlLDRSPMEEELLDWAEENGLPLLAYSPLARGP------------------------------------- 200
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1139695540 242 fegialvekalqaaygasapsmTSAALRWMYHHSqlqgaHGDAVILGMSSLEQLEQNLA 300
Cdd:cd06660 201 ----------------------AQLALAWLLSQP-----FVTVPIVGARSPEQLEENLA 232
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
13-319 |
3.86e-58 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 189.06 E-value: 3.86e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 13 VLGAMEMG---RRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILG-GLGLRMGSSDcRVKIATKANPWIGN---S 85
Cdd:pfam00248 2 GLGTWQLGggwGPISKEEALEALRAALEAGINFIDTAEVYGDGKSEELLGeALKDYPVKRD-KVVIATKVPDGDGPwpsG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 86 LKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEIctlcKSNGWILP 165
Cdd:pfam00248 81 GSKENIRKSLEESLKRLGTDYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKA----LTKGKIPI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 166 TVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGTQWAEIYrnhfwkehhfEGI 245
Cdd:pfam00248 157 VAVQVEYNLLRRRQEEELLEYCKKNGIPLIAYSPLGGGLLTGKYTRDPDKGPGERRRLLKKGTPLNL----------EAL 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1139695540 246 ALVEKaLQAAYGAsapSMTSAALRWMYHHSQlqgahGDAVILGMSSLEQLEQNLAAAeEGPLEPAVVDAFNQAW 319
Cdd:pfam00248 227 EALEE-IAKEHGV---SPAQVALRWALSKPG-----VTIPIPGASNPEQLEDNLGAL-EFPLSDEEVARIDELL 290
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
14-303 |
5.86e-58 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 189.35 E-value: 5.86e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAM----EMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLglrMGSSDCRVKIATK-------ANP-W 81
Cdd:cd19080 15 LGTMtfgtEWGWGADREEARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEF---IAGNRDRIVLATKytmnrrpGDPnA 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 82 IGNSLKpdSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNG 161
Cdd:cd19080 92 GGNHRK--NLRRSVEASLRRLQTDYIDLLYVHAWDFTTPVEEVMRALDDLVRAGKVLYVGISDTPAWVVARANTLAELRG 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 162 WILPTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKY-KYEDKDGKQPVGRFFGTQwaeiyrnHFwKEH 240
Cdd:cd19080 170 WSPFVALQIEYSLLERTPERELLPMARALGLGVTPWSPLGGGLLTGKYqRGEEGRAGEAKGVTVGFG-------KL-TER 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1139695540 241 HFEgIALVEKALQAAYGAsapSMTSAALRWMYHHSQlqgahGDAVILGMSSLEQLEQNLAAAE 303
Cdd:cd19080 242 NWA-IVDVVAAVAEELGR---SAAQVALAWVRQKPG-----VVIPIIGARTLEQLKDNLGALD 295
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
14-303 |
6.52e-58 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 189.32 E-value: 6.52e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLglrmgSSDCR--VKIATKA----NPWI---GN 84
Cdd:cd19087 18 LGTMNFGGRTDEETSFAIMDRALDAGINFFDTADVYGGGRSEEIIGRW-----IAGRRddIVLATKVfgpmGDDPndrGL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 85 SLKpdSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWIL 164
Cdd:cd19087 93 SRR--HIRRAVEASLRRLQTDYIDLYQMHHFDRDTPLEETLRALDDLVRQGKIRYIGVSNFAAWQIAKAQGIAARRGLLR 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 165 PTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKyedKDGKQPVGRFFGtqwAEIYRNHFWKEHHFEG 244
Cdd:cd19087 171 FVSEQPMYNLLKRQAELEILPAARAYGLGVIPYSPLAGGLLTGKYG---KGKRPESGRLVE---RARYQARYGLEEYRDI 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1139695540 245 IALVEkALQAAYGASAPSMtsaALRWMYHHSQLQGAhgdavILGMSSLEQLEQNLAAAE 303
Cdd:cd19087 245 AERFE-ALAAEAGLTPASL---ALAWVLSHPAVTSP-----IIGPRTLEQLEDSLAALE 294
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
13-316 |
5.23e-57 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 186.65 E-value: 5.23e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 13 VLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSD-------GQSETILGGLglrMGSSDCR--VKIATKANPWIG 83
Cdd:cd19081 13 CLGTMVFGWTADEETSFALLDAFVDAGGNFIDTADVYSAwvpgnagGESETIIGRW---LKSRGKRdrVVIATKVGFPMG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 84 NS---LKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSN 160
Cdd:cd19081 90 PNgpgLSRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLGALNDLIRQGKVRYIGASNYSAWRLQEALELSRQH 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 161 GWILPTVYQGMYSATTRQ-VETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGrffgtqwAEIYRNHFwKE 239
Cdd:cd19081 170 GLPRYVSLQPEYNLVDREsFEGELLPLCREEGIGVIPYSPLAGGFLTGKYRSEADLPGSTRR-------GEAAKRYL-NE 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1139695540 240 HHFEGIALVEkALQAAYGAsapSMTSAALRWMYHHSQLqgahgDAVILGMSSLEQLEQNLAAAeEGPLEPAVVDAFN 316
Cdd:cd19081 242 RGLRILDALD-EVAAEHGA---TPAQVALAWLLARPGV-----TAPIAGARTVEQLEDLLAAA-GLRLTDEEVARLD 308
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
14-303 |
1.58e-53 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 177.33 E-value: 1.58e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMEMGRRM-----DAPTSAAVTRAfLERGHTEIDTAFLYSDGQSETILGGL--GLRmgssDcRVKIATKANPWIGNS- 85
Cdd:cd19084 9 LGTWAIGGTWwgevdDQESIEAIKAA-IDLGINFFDTAPVYGFGHSEEILGKAlkGRR----D-DVVIATKCGLRWDGGk 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 86 -----LKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsn 160
Cdd:cd19084 83 gvtkdLSPESIRKEVEQSLRRLQTDYIDLYQIHWPDPNTPIEETAEALEKLKKEGKIRYIGVSNFSVEQLEEARKYGP-- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 161 gwilPTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVgRffgtqwaeiYRNHFWKEH 240
Cdd:cd19084 161 ----IVSLQPPYSMLEREIEEELLPYCRENGIGVLPYGPLAQGLLTGKYKKEPTFPPDDR-R---------SRFPFFRGE 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1139695540 241 HFE-GIALVE--KALQAAYGasaPSMTSAALRWMYHHSQLqgahgDAVILGMSSLEQLEQNLAAAE 303
Cdd:cd19084 227 NFEkNLEIVDklKEIAEKYG---KSLAQLAIAWTLAQPGV-----TSAIVGAKNPEQLEENAGALD 284
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
10-303 |
7.92e-49 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 165.86 E-value: 7.92e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 10 PATVLGAMEMGRR---------MDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGlGLRmGSSDcRVKIATKANP 80
Cdd:cd19091 14 SELALGTMTFGGGggffgawggVDQEEADRLVDIALDAGINFFDTADVYSEGESEEILGK-ALK-GRRD-DVLIATKVRG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 81 WIGNSlkPDSV---RSQL----ETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEI 153
Cdd:cd19091 91 RMGEG--PNDVglsRHHIiravEASLKRLGTDYIDLYQLHGFDALTPLEETLRALDDLVRQGKVRYIGVSNFSAWQIMKA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 154 CTLCKSNGWILPTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKyedKDGKQPVGRFFGTQWAEIYR 233
Cdd:cd19091 169 LGISERRGLARFVALQAYYSLLGRDLEHELMPLALDQGVGLLVWSPLAGGLLSGKYR---RGQPAPEGSRLRRTGFDFPP 245
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1139695540 234 nhFWKEHhfeGIALVE--KALQAAYGASAPsmtSAALRWMyhhsqLQGAHGDAVILGMSSLEQLEQNLAAAE 303
Cdd:cd19091 246 --VDRER---GYDVVDalREIAKETGATPA---QVALAWL-----LSRPTVSSVIIGARNEEQLEDNLGAAG 304
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
28-318 |
1.05e-45 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 156.98 E-value: 1.05e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 28 SAAVTRAFLERGHTEIDTAFLYSDGQSETILGglgLRMGSSDCRVKIATKANPwigNSLKPDSVRSQLETSLKRLQCPRV 107
Cdd:cd19085 25 SIATIHAALDAGINFFDTAEAYGDGHSEEVLG---KALKGRRDDVVIATKVSP---DNLTPEDVRKSCERSLKRLGTDYI 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 108 DLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwilPTVYQGMYSATTRQVETELFPCL 187
Cdd:cd19085 99 DLYQIHWPSSDVPLEETMEALEKLKEEGKIRAIGVSNFGPAQLEEALDAGR------IDSNQLPYNLLWRAIEYEILPFC 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 188 RHFGLRFYAYNPLAGGLLTGKYkyeDKDGKQPVGRFFGTqwaeiYRNHFWKEHH---FEGIALVeKALQAAYGAsapSMT 264
Cdd:cd19085 173 REHGIGVLAYSPLAQGLLTGKF---SSAEDFPPGDARTR-----LFRHFEPGAEeetFEALEKL-KEIADELGV---TMA 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1139695540 265 SAALRWMYHHSQLqgahgDAVILGMSSLEQLEQNLAAAEEgPLEPAVVDAFNQA 318
Cdd:cd19085 241 QLALAWVLQQPGV-----TSVIVGARNPEQLEENAAAVDL-ELSPSVLERLDEI 288
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
14-301 |
1.66e-44 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 154.28 E-value: 1.66e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMEMGRR------MDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDcRVKIATKANPWIGNS-- 85
Cdd:cd19079 17 LGCMSFGDPkwrpwvLDEEESRPIIKRALDLGINFFDTANVYSGGASEEILGRALKEFAPRD-EVVIATKVYFPMGDGpn 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 86 ---LKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGW 162
Cdd:cd19079 96 grgLSRKHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIGASSMYAWQFAKALHLAEKNGW 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 163 ILPTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKyedKDGKQPVGRFFGTQWAEIYRnhfwKEHHF 242
Cdd:cd19079 176 TKFVSMQNHYNLLYREEEREMIPLCEEEGIGVIPWSPLARGRLARPWG---DTTERRRSTTDTAKLKYDYF----TEADK 248
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1139695540 243 EGIALVEKaLQAAYGAsapSMTSAALRWMYHHSQlqgahGDAVILGMSSLEQLEQNLAA 301
Cdd:cd19079 249 EIVDRVEE-VAKERGV---SMAQVALAWLLSKPG-----VTAPIVGATKLEHLEDAVAA 298
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
20-303 |
1.03e-42 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 149.28 E-value: 1.03e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 20 GRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGL--GLRMGSsdcrVKIATKA----NPWI---GNSLKpdS 90
Cdd:cd19074 16 GGQVDDEDAKACVRKAYDLGINFFDTADVYAAGQAEEVLGKAlkGWPRES----YVISTKVfwptGPGPndrGLSRK--H 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 91 VRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQG 170
Cdd:cd19074 90 IFESIHASLKRLQLDYVDIYYCHRYDPETPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAEAHDLARQFGLIPPVVEQP 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 171 MYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYkyedKDGKQPVGRFFGTQWaeiyRNHFWKEHHF--EGIALV 248
Cdd:cd19074 170 QYNMLWREIEEEVIPLCEKNGIGLVVWSPLAQGLLTGKY----RDGIPPPSRSRATDE----DNRDKKRRLLtdENLEKV 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1139695540 249 EKaLQAAYGASAPSMTSAALRWMyhhsqLQGAHGDAVILGMSSLEQLEQNLAAAE 303
Cdd:cd19074 242 KK-LKPIADELGLTLAQLALAWC-----LRNPAVSSAIIGASRPEQLEENVKASG 290
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
14-303 |
5.00e-41 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 145.05 E-value: 5.00e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMEM---GRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGlGLRMGSSdcRVKIATK-------ANPWIG 83
Cdd:cd19076 17 LGCMGMsafYGPADEEESIATLHRALELGVTFLDTADMYGPGTNEELLGK-ALKDRRD--EVVIATKfgivrdpGSGFRG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 84 NSLKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYA------AWEVAEIctlc 157
Cdd:cd19076 94 VDGRPEYVRAACEASLKRLGTDVIDLYYQHRVDPNVPIEETVGAMAELVEEGKVRYIGLSEASadtirrAHAVHPI---- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 158 ksngwilpTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGtqwaeiyrnhFW 237
Cdd:cd19076 170 --------TAVQSEYSLWTRDIEDEVLPTCRELGIGFVAYSPLGRGFLTGAIKSPEDLPEDDFRRNNP----------RF 231
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 238 KEHHFEG-IALVEK--ALQAAYGASAPSMtsaALRWMYHhsqlQGAhgDAV-ILGMSSLEQLEQNLAAAE 303
Cdd:cd19076 232 QGENFDKnLKLVEKleAIAAEKGCTPAQL---ALAWVLA----QGD--DIVpIPGTKRIKYLEENVGALD 292
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
28-303 |
1.19e-37 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 136.26 E-value: 1.19e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 28 SAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSsdcRVKIATKANP-W-----IGNSLKPDSVRSQLETSLKR 101
Cdd:cd19102 28 SIAAIRAALDLGINWIDTAAVYGLGHSEEVVGRALKGLRD---RPIVATKCGLlWdeegrIRRSLKPASIRAECEASLRR 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 102 LQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTlcksngwILP-TVYQGMYSATTRQVE 180
Cdd:cd19102 105 LGVDVIDLYQIHWPDPDEPIEEAWGALAELKEEGKVRAIGVSNFSVDQMKRCQA-------IHPiASLQPPYSLLRRGIE 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 181 TELFPCLRHFGLRFYAYNPLAGGLLTGKYKYE-----DKDGKQPVGRFFgtqwAEIYRNHFwkehhfegIALVE--KALQ 253
Cdd:cd19102 178 AEILPFCAEHGIGVIVYSPMQSGLLTGKMTPErvaslPADDWRRRSPFF----QEPNLARN--------LALVDalRPIA 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1139695540 254 AAYGASAPSMtsaALRWMYHHSQLQGAhgdavILGMSSLEQLEQNLAAAE 303
Cdd:cd19102 246 ERHGRTVAQL---AIAWVLRRPEVTSA-----IVGARRPDQIDETVGAAD 287
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
14-316 |
2.76e-37 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 135.77 E-value: 2.76e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMEMGRRMD-APTSAAVTRAFlERGHTEIDTAFLYS-------DGQSETILGGLglrMGSSDCRVK--IATKA----- 78
Cdd:cd19094 6 LGTMTWGEQNTeAEAHEQLDYAF-DEGVNFIDTAEMYPvppspetQGRTEEIIGSW---LKKKGNRDKvvLATKVagpge 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 79 -NPWIGN---SLKPDSVRSQLETSLKRLQCPRVDLFYLHAPDH------------------SAPVEETLRACHQLHQEGK 136
Cdd:cd19094 82 gITWPRGggtRLDRENIREAVEGSLKRLGTDYIDLYQLHWPDRytplfgggyytepseeedSVSFEEQLEALGELVKAGK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 137 FVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDG 216
Cdd:cd19094 162 IRHIGLSNETPWGVMKFLELAEQLGLPRIVSIQNPYSLLNRNFEEGLAEACHRENVGLLAYSPLAGGVLTGKYLDGAARP 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 217 KQpvGRFF-GTQWAEIYRNHFWKEHHFEGIALVEKalqaaYGAsapSMTSAALRWMYHHSqlqgaHGDAVILGMSSLEQL 295
Cdd:cd19094 242 EG--GRLNlFPGYMARYRSPQALEAVAEYVKLARK-----HGL---SPAQLALAWVRSRP-----FVTSTIIGATTLEQL 306
|
330 340
....*....|....*....|.
gi 1139695540 296 EQNLAAAeEGPLEPAVVDAFN 316
Cdd:cd19094 307 KENIDAF-DVPLSDELLAEID 326
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
23-303 |
1.19e-36 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 133.70 E-value: 1.19e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 23 MDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLgLRmGSSDCRVKIATK-ANPWIGNSLK----PDSVRSQLET 97
Cdd:cd19083 30 LDEEEGKDLVREALDNGVNLLDTAFIYGLGRSEELVGEV-LK-EYNRNEVVIATKgAHKFGGDGSVlnnsPEFLRSAVEK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 98 SLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEictlckSNGWILPTVYQGMYSATTR 177
Cdd:cd19083 108 SLKRLNTDYIDLYYIHFPDGETPKAEAVGALQELKDEGKIRAIGVSNFSLEQLKE------ANKDGYVDVLQGEYNLLQR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 178 QVETELFPCLRHFGLRFYAYNPLAGGLLTGKY----KYEDKDGKQPVGRFFGTQWAEIYRNhfwkehhfegialVEKALQ 253
Cdd:cd19083 182 EAEEDILPYCVENNISFIPYFPLASGLLAGKYtkdtKFPDNDLRNDKPLFKGERFSENLDK-------------VDKLKS 248
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1139695540 254 AAYGASApSMTSAALRWMYHHSQLqgahgDAVILGMSSLEQLEQNLAAAE 303
Cdd:cd19083 249 IADEKGV-TVAHLALAWYLTRPAI-----DVVIPGAKRAEQVIDNLKALD 292
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
20-310 |
1.91e-36 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 133.15 E-value: 1.91e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 20 GRRMDAPTSAAVTRAFLERGHTEIDTAFLY--SDGQSETILGglglRMGSSDCRVK-----IATKA--NPW-----IGNS 85
Cdd:cd19089 23 GDYTSPEEARELLRTAFDLGITHFDLANNYgpPPGSAEENFG----RILKRDLRPYrdelvISTKAgyGMWpgpygDGGS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 86 LKpdSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGwILP 165
Cdd:cd19089 99 RK--YLLASLDQSLKRMGLDYVDIFYHHRYDPDTPLEETMTALADAVRSGKALYVGISNYPGAKARRAIALLRELG-VPL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 166 TVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYkyedKDGKQPVGRFFGTQWaeiyrnhFWKEHHFEGi 245
Cdd:cd19089 176 IIHQPRYSLLDRWAEDGLLEVLEEAGIGFIAFSPLAQGLLTDKY----LNGIPPDSRRAAESK-------FLTEEALTP- 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 246 ALVEKALQ-----AAYGASAPSMtsaALRWMYHHSQLQgahgdAVILGMSSLEQLEQNLAAAEEGPLEPA 310
Cdd:cd19089 244 EKLEQLRKlnkiaAKRGQSLAQL---ALSWVLRDPRVT-----SVLIGASSPSQLEDNVAALKNLDFSEE 305
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
10-303 |
5.93e-36 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 131.30 E-value: 5.93e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 10 PATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYS-------DGQSETILGG-LGLRmGSSDcRVKIATK--AN 79
Cdd:cd19752 1 SELCLGTMYFGTRTDEETSFAILDRYVAAGGNFLDTANNYAfwteggvGGESERLIGRwLKDR-GNRD-DVVIATKvgAG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 80 PWIGNS-------LKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAE 152
Cdd:cd19752 79 PRDPDGgpespegLSAETIEQEIDKSLRRLGTDYIDLYYAHVDDRDTPLEETLEAFNELVKAGKVRAIGASNFAAWRLER 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 153 ICTLCKSNGWILPTVYQGMYS----------ATTRQVETELFPCLR-HFGLRFYAYNPLAGGLLT-------GKYKYEDK 214
Cdd:cd19752 159 ARQIARQQGWAEFSAIQQRHSylrprpgadfGVQRIVTDELLDYASsRPDLTLLAYSPLLSGAYTrpdrplpEQYDGPDS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 215 DGKQPVGRffgtqwaEIYRNHfwkehhfegialvekalqaayGASApsmTSAALRWMyhhsqLQGAHGDAVILGMSSLEQ 294
Cdd:cd19752 239 DARLAVLE-------EVAGEL---------------------GATP---NQVVLAWL-----LHRTPAIIPLLGASTVEQ 282
|
....*....
gi 1139695540 295 LEQNLAAAE 303
Cdd:cd19752 283 LEENLAALD 291
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
13-303 |
5.16e-34 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 126.13 E-value: 5.16e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 13 VLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSD----GQSETILGglglR-MGSSDCR--VKIATK-ANPWIGN 84
Cdd:cd19082 4 VLGTADFGTRIDEEEAFALLDAFVELGGNFIDTARVYGDwverGASERVIG----EwLKSRGNRdkVVIATKgGHPDLED 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 85 S----LKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNyaaWEVAEIC---TLC 157
Cdd:cd19082 80 MsrsrLSPEDIRADLEESLERLGTDYIDLYFLHRDDPSVPVGEIVDTLNELVRAGKIRAFGASN---WSTERIAeanAYA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 158 KSNGWILPTVYQGMYSATTRQVETELFPCL-------RHF----GLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGt 226
Cdd:cd19082 157 KAHGLPGFAASSPQWSLARPNEPPWPGPTLvamdeemRAWheenQLPVFAYSSQARGFFSKRAAGGAEDDSELRRVYYS- 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1139695540 227 qwaeiyrnhfwkEHHFEGIALVeKALQAAYGASApsmTSAALRWMYHHSQLQGAhgdavILGMSSLEQLEQNLAAAE 303
Cdd:cd19082 236 ------------EENFERLERA-KELAEEKGVSP---TQIALAYVLNQPFPTVP-----IIGPRTPEQLRDSLAAAD 291
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
10-303 |
4.85e-32 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 121.61 E-value: 4.85e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 10 PATVLGAMEMG-----RRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGL--GLRMgssdcRVKIATKANPW- 81
Cdd:cd19149 12 SVIGLGTWAIGggpwwGGSDDNESIRTIHAALDLGINLIDTAPAYGFGHSEEIVGKAikGRRD-----KVVLATKCGLRw 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 82 ---------------IGNSLKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYA 146
Cdd:cd19149 87 dreggsfffvrdgvtVYKNLSPESIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEETMEALEELKRQGKIRAIGASNVS 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 147 AWEVAEICtlckSNGWIlpTVYQGMYSATTRQVETELFP-CLRHfGLRFYAYNPLAGGLLTGKYKyedkdgkqPVGRFFG 225
Cdd:cd19149 167 VEQIKEYV----KAGQL--DIIQEKYSMLDRGIEKELLPyCKKN-NIAFQAYSPLEQGLLTGKIT--------PDREFDA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 226 TQWaeIYRNHFWKEHHFEGI-ALVE--KALQAAYGAsapSMTSAALRWMYHHSQLqgahgDAVILGMSSLEQLEQNLAAA 302
Cdd:cd19149 232 GDA--RSGIPWFSPENREKVlALLEkwKPLCEKYGC---TLAQLVIAWTLAQPGI-----TSALCGARKPEQAEENAKAG 301
|
.
gi 1139695540 303 E 303
Cdd:cd19149 302 D 302
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
20-314 |
4.90e-32 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 121.55 E-value: 4.90e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 20 GRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGG----LGLRmgSSDcrVKIATKANpWIGNSLKPDS----- 90
Cdd:cd19143 25 GNQVDVDEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQaikeLGWP--RSD--YVVSTKIF-WGGGGPPPNDrglsr 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 91 --VRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVY 168
Cdd:cd19143 100 khIVEGTKASLKRLQLDYVDLVFCHRPDPATPIEETVRAMNDLIDQGKAFYWGTSEWSAQQIEEAHEIADRLGLIPPVME 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 169 QGMYSATTRQ-VETELFPCLRHFGLRFYAYNPLAGGLLTGKYkyedkDGKQPVGRFFGTQwaeiyrNHFWKEHHFEG--- 244
Cdd:cd19143 180 QPQYNLFHRErVEVEYAPLYEKYGLGTTTWSPLASGLLTGKY-----NNGIPEGSRLALP------GYEWLKDRKEElgq 248
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1139695540 245 --IALVEKALQAA--YGASAPSMtsaALRWMyhhsqLQGAHGDAVILGMSSLEQLEQNLAAAEEGP-LEPAVVDA 314
Cdd:cd19143 249 ekIEKVRKLKPIAeeLGCSLAQL---AIAWC-----LKNPNVSTVITGATKVEQLEENLKALEVLPkLTPEVMEK 315
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
10-301 |
1.53e-31 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 118.87 E-value: 1.53e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 10 PATVLGAMEMGRRMDAPTS-----AAVTRAFLERGHTEIDTAFLYSDGQSETILGglglRMGSSDCRVK--IATKANPWi 82
Cdd:cd19072 5 PVLGLGTWGIGGGMSKDYSddkkaIEALRYAIELGINLIDTAEMYGGGHAEELVG----KAIKGFDREDlfITTKVSPD- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 83 gnSLKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGw 162
Cdd:cd19072 80 --HLKYDDVIKAAKESLKRLGTDYIDLYLIHWPNPSIPIEETLRAMEELVEEGKIRYIGVSNFSLEELEEAQSYLKKGP- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 163 ilPTVYQGMYSATTRQVETELFP-CLRHfGLRFYAYNPLAGGLLTGKykyedkdgkqpvgrffgtqwaeiyrnhfwkehh 241
Cdd:cd19072 157 --IVANQVEYNLFDREEESGLLPyCQKN-GIAIIAYSPLEKGKLSNA--------------------------------- 200
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 242 fEGIALVEKaLQAAYGASApsmTSAALRWMYHHSqlqgahGDAVILGMSSLEQLEQNLAA 301
Cdd:cd19072 201 -KGSPLLDE-IAKKYGKTP---AQIALNWLISKP------NVIAIPKASNIEHLEENAGA 249
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
3-301 |
2.56e-30 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 117.14 E-value: 2.56e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 3 RQLS-----RARPaTVLGAMEMGRR-------MDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLglrMGSSDC 70
Cdd:cd19146 1 RQLSptagvRVSP-LCLGAMSFGEAwksmmgeCDKETAFKLLDAFYEQGGNFIDTANNYQGEESERWVGEW---MASRGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 71 R--VKIATK--------ANPWI-----GNSLKpdSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEG 135
Cdd:cd19146 77 RdeMVLATKyttgyrrgGPIKIksnyqGNHAK--SLRLSVEASLKKLQTSYIDILYVHWWDYTTSIPELMQSLNHLVAAG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 136 KFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKD 215
Cdd:cd19146 155 KVLYLGVSDTPAWVVSKANAYARAHGLTQFVVYQGHWSAAFRDFERDILPMCEAEGMALAPWGVLGQGQFRTEEEFKRRG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 216 GkqpVGRFFGTQwaeiyrnhfwKEHHFEgialVEKALQAAYGASAPSMTSAALRWMYHHSQLqgahgdaV--ILGMSSLE 293
Cdd:cd19146 235 R---SGRKGGPQ----------TEKERK----VSEKLEKVAEEKGTAITSVALAYVMHKAPY-------VfpIVGGRKVE 290
|
....*...
gi 1139695540 294 QLEQNLAA 301
Cdd:cd19146 291 HLKGNIEA 298
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
20-302 |
5.09e-30 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 115.79 E-value: 5.09e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 20 GRRMDAPTSAAVTRAfLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDcRVKIATK--ANPWignSLKPDSVRSQLET 97
Cdd:cd19093 21 GEYGDEDLQAAFDAA-LEAGVNLFDTAEVYGTGRSERLLGRFLKELGDRD-EVVIATKfaPLPW---RLTRRSVVKALKA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 98 SLKRLQCPRVDLFYLHAPDH-SAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGwILPTVYQGMYSATT 176
Cdd:cd19093 96 SLERLGLDSIDLYQLHWPGPwYSQIEALMDGLADAVEEGLVRAVGVSNYSADQLRRAHKALKERG-VPLASNQVEYSLLY 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 177 RQVET-ELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGTQWAEIYrnhfwkehhfegiALVE--KALQ 253
Cdd:cd19093 175 RDPEQnGLLPACDELGITLIAYSPLAQGLLTGKYSPENPPPGGRRRLFGRKNLEKVQ-------------PLLDalEEIA 241
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1139695540 254 AAYGAsapSMTSAALRWMYHHSQLqgahgdaVILGMSSLEQLEQNLAAA 302
Cdd:cd19093 242 EKYGK---TPAQVALNWLIAKGVV-------PIPGAKNAEQAEENAGAL 280
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
14-311 |
5.12e-30 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 115.34 E-value: 5.12e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMEMGRRMDAptSAAVTRAFLERGHTEIDTAFLYsdGQSETILGgLGLRmGSSDCRVKIATKANPWIGNSLK--PDSV 91
Cdd:cd19090 10 LGGVFGGVDDDE--AVATIRAALDLGINYIDTAPAY--GDSEERLG-LALA-ELPREPLVLSTKVGRLPEDTADysADRV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 92 RSQLETSLKRLQCPRVDLFYLHAPDHSAPVEET-----LRACHQLHQEGKFVELGLsnyAAWEVAEICTLCKSNGW--IL 164
Cdd:cd19090 84 RRSVEESLERLGRDRIDLLMIHDPERVPWVDILapggaLEALLELKEEGLIKHIGL---GGGPPDLLRRAIETGDFdvVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 165 ptVYQGmYSATTRQVETELFP-CLRHfGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGTQWAEIYrnhfwkehhfe 243
Cdd:cd19090 161 --TANR-YTLLDQSAADELLPaAARH-GVGVINASPLGMGLLAGRPPERVRYTYRWLSPELLDRAKRLY----------- 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1139695540 244 gialvekALQAAYGAsapSMTSAALRWMYHHSQLqgahgDAVILGMSSLEQLEQNLAAAeEGPLEPAV 311
Cdd:cd19090 226 -------ELCDEHGV---PLPALALRFLLRDPRI-----STVLVGASSPEELEQNVAAA-EGPLPEEL 277
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
14-303 |
6.48e-30 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 115.41 E-value: 6.48e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMEM----GRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILG-GLGLRMGssdcRVKIATK--------ANP 80
Cdd:cd19078 9 LGCMGMshgyGPPPDKEEMIELIRKAVELGITFFDTAEVYGPYTNEELVGeALKPFRD----QVVIATKfgfkidggKPG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 81 WIGNSLKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSnyaawEVAEiCTLCKSN 160
Cdd:cd19078 85 PLGLDSRPEHIRKAVEGSLKRLQTDYIDLYYQHRVDPNVPIEEVAGTMKELIKEGKIRHWGLS-----EAGV-ETIRRAH 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 161 GwILP-TVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKY----KYEDKDGKQPVGRFFgtqwaeiyrnh 235
Cdd:cd19078 159 A-VCPvTAVQSEYSMMWREPEKEVLPTLEELGIGFVPFSPLGKGFLTGKIdentKFDEGDDRASLPRFT----------- 226
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1139695540 236 fwKEHHFEGIALVE--KALQAAYGAsapsmTSA--ALRWMYHhsqlQGAHgdAV-ILGMSSLEQLEQNLAAAE 303
Cdd:cd19078 227 --PEALEANQALVDllKEFAEEKGA-----TPAqiALAWLLA----KKPW--IVpIPGTTKLSRLEENIGAAD 286
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
14-271 |
1.69e-29 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 114.33 E-value: 1.69e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMEMGRRM----DAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDcRVKIATKAN-PWIGNSLK- 87
Cdd:cd19148 9 LGTWAIGGWMwggtDEKEAIETIHKALDLGINLIDTAPVYGFGLSEEIVGKALKEYGKRD-RVVIATKVGlEWDEGGEVv 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 88 ----PDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAaweVAEICTLCKsnGWI 163
Cdd:cd19148 88 rnssPARIRKEVEDSLRRLQTDYIDLYQVHWPDPLVPIEETAEALKELLDEGKIRAIGVSNFS---PEQMETFRK--VAP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 164 LPTVyQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGK----YKYEDKDGKQPVGRFFGTQWAeiyrnhfwke 239
Cdd:cd19148 163 LHTV-QPPYNLFEREIEKDVLPYARKHNIVTLAYGALCRGLLSGKmtkdTKFEGDDLRRTDPKFQEPRFS---------- 231
|
250 260 270
....*....|....*....|....*....|..
gi 1139695540 240 HHFEGIALVEKALQAAYGASAPSMtsaALRWM 271
Cdd:cd19148 232 QYLAAVEELDKLAQERYGKSVIHL---AVRWL 260
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
14-303 |
4.04e-29 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 112.31 E-value: 4.04e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAM------EMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLglrMGSSDCRVKIATKA-------NP 80
Cdd:cd19088 6 YGAMrltgpgIWGPPADREEAIAVLRRALELGVNFIDTADSYGPDVNERLIAEA---LHPYPDDVVIATKGglvrtgpGW 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 81 WIGNSlKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNY------AAWEVAEIC 154
Cdd:cd19088 83 WGPDG-SPEYLRQAVEASLRRLGLDRIDLYQLHRIDPKVPFEEQLGALAELQDEGLIRHIGLSNVtvaqieEARAIVRIV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 155 TLcksngwilptvyQGMYSATTRQVETELFPCLRHfGLRFYAYNPLAGGLLTgkykyedkdgkQPVGRFfgtqwaeiyrn 234
Cdd:cd19088 162 SV------------QNRYNLANRDDEGVLDYCEAA-GIAFIPWFPLGGGDLA-----------QPGGLL----------- 206
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1139695540 235 hfwkehhfegialveKALQAAYGASAPsmtSAALRWMYHHSQlqgahGDAVILGMSSLEQLEQNLAAAE 303
Cdd:cd19088 207 ---------------AEVAARLGATPA---QVALAWLLARSP-----VMLPIPGTSSVEHLEENLAAAG 252
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
13-226 |
2.22e-28 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 111.84 E-value: 2.22e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 13 VLGAMEMG-------RRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLglrMGSSDCR--VKIATK------ 77
Cdd:cd19147 14 ILGAMSIGdawsgfmGSMDKEQAFELLDAFYEAGGNFIDTANNYQDEQSETWIGEW---MKSRKNRdqIVIATKfttdyk 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 78 --------ANPWIGNSLKpdSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWE 149
Cdd:cd19147 91 ayevgkgkAVNYCGNHKR--SLHVSVRDSLRKLQTDWIDILYVHWWDYTTSIEEVMDSLHILVQQGKVLYLGVSDTPAWV 168
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1139695540 150 VAEICTLCKSNGWILPTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGG-LLTGKYKYEDKDGKQPVGRFFGT 226
Cdd:cd19147 169 VSAANYYATAHGKTPFSVYQGRWNVLNRDFERDIIPMARHFGMALAPWDVLGGGkFQSKKAVEERKKNGEGLRSFVGG 246
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
2-301 |
1.43e-25 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 104.45 E-value: 1.43e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 2 SRQLSRARPA-TVLGAMEMG-------RRMDAPTSAAVTRAFlERGHTEIDTAFLYSDgqSETILGGLGLRMGSSDCRVK 73
Cdd:cd19144 3 TRTLGRNGPSvPALGFGAMGlsafygpPKPDEERFAVLDAAF-ELGCTFWDTADIYGD--SEELIGRWFKQNPGKREKIF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 74 IATK---------ANPWIGNSlkPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSN 144
Cdd:cd19144 80 LATKfgieknvetGEYSVDGS--PEYVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEKTVAAMAELVQEGKIKHIGLSE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 145 YAAWEVAEICTlcksngwILP-TVYQGMYSATTRQVET---ELFPCLRHFGLRFYAYNPLAGGLLTGKYK----YEDKDG 216
Cdd:cd19144 158 CSAETLRRAHA-------VHPiAAVQIEYSPFSLDIERpeiGVLDTCRELGVAIVAYSPLGRGFLTGAIRspddFEEGDF 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 217 KQPVGRffgtqwaeiyrnhFWKEHHFEGIALVE--KALQAAYGASAPSMTsaaLRWMYhhsqlqgAHGDAV--ILGMSSL 292
Cdd:cd19144 231 RRMAPR-------------FQAENFPKNLELVDkiKAIAKKKNVTAGQLT---LAWLL-------AQGDDIipIPGTTKL 287
|
....*....
gi 1139695540 293 EQLEQNLAA 301
Cdd:cd19144 288 KRLEENLGA 296
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
14-301 |
4.93e-25 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 101.01 E-value: 4.93e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMEMGRRMDAPTS-----AAVTRAfLERGHTEIDTAFLYSDGQSETILGGLglrMGSSDCRVKIATKANPWIGNSLK- 87
Cdd:cd19086 8 FGTWGLGGDWWGDVDdaeaiRALRAA-LDLGINFFDTADVYGDGHSERLLGKA---LKGRRDKVVIATKFGNRFDGGPEr 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 88 -----PDSVRSQLETSLKRLQCPRVDLFYLH-APDHSAPVEETLRACHQLHQEGKFVELGLS---NYAAWEVAEictlck 158
Cdd:cd19086 84 pqdfsPEYIREAVEASLKRLGTDYIDLYQLHnPPDEVLDNDELFEALEKLKQEGKIRAYGVSvgdPEEALAALR------ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 159 sNGWIlpTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKykyedkdgkqpvgrffgtqwaeiyrnhfwk 238
Cdd:cd19086 158 -RGGI--DVVQVIYNLLDQRPEEELFPLAEEHGVGVIARVPLASGLLTGK------------------------------ 204
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1139695540 239 ehhfegialvekalqaaygasapsMTSAALRWMYHHSQLqgahgDAVILGMSSLEQLEQNLAA 301
Cdd:cd19086 205 ------------------------LAQAALRFILSHPAV-----STVIPGARSPEQVEENAAA 238
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
29-301 |
2.35e-24 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 100.56 E-value: 2.35e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 29 AAVTRAFlERGHTEIDTAFLYSD--GQSETILGglglRMGSSDCR-----VKIATKAN--PWIG-----NSLKpdSVRSQ 94
Cdd:cd19151 34 AMLRRAF-DLGITHFDLANNYGPppGSAEENFG----RILKEDLKpyrdeLIISTKAGytMWPGpygdwGSKK--YLIAS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 95 LETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGwiLPT-VYQGMYS 173
Cdd:cd19151 107 LDQSLKRMGLDYVDIFYHHRPDPETPLEETMGALDQIVRQGKALYVGISNYPPEEAREAAAILKDLG--TPClIHQPKYS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 174 ATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKyedkdGKQPVGRFFGTQWAeiyrnhFWKEHHF--EGIALVeKA 251
Cdd:cd19151 185 MFNRWVEEGLLDVLEEEGIGCIAFSPLAQGLLTDRYL-----NGIPEDSRAAKGSS------FLKPEQIteEKLAKV-RR 252
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1139695540 252 LQAAYGASAPSMTSAALRWMYHHSQLQgahgdAVILGMSSLEQLEQNLAA 301
Cdd:cd19151 253 LNEIAQARGQKLAQMALAWVLRNKRVT-----SVLIGASKPSQIEDAVGA 297
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
14-301 |
4.57e-24 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 99.81 E-value: 4.57e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMEMGRRMDAPTSA----AVTRAFLERGHTEIDTAFLYSDGQSETILGGlGLRMGSSDcRVKIATKANPWIGNSLK-- 87
Cdd:cd19145 17 LGCMGLSGDYGAPKPEeegiALIHHAFNSGVTFLDTSDIYGPNTNEVLLGK-ALKDGPRE-KVQLATKFGIHEIGGSGve 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 88 ----PDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAwevaeiCTLCKSNGwI 163
Cdd:cd19145 95 vrgdPAYVRAACEASLKRLDVDYIDLYYQHRIDTTVPIEITMGELKKLVEEGKIKYIGLSEASA------DTIRRAHA-V 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 164 LP-TVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYE----DKDGKQPVGRFfgtQWAEIYRNHfwk 238
Cdd:cd19145 168 HPiTAVQLEWSLWTRDIEEEIIPTCRELGIGIVPYSPLGRGFFAGKAKLEelleNSDVRKSHPRF---QGENLEKNK--- 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1139695540 239 ehhfegiALVEK--ALQAAYGASAPSMtsaALRWMYHhsqlqgaHGDAV--ILGMSSLEQLEQNLAA 301
Cdd:cd19145 242 -------VLYERveALAKKKGCTPAQL---ALAWVLH-------QGEDVvpIPGTTKIKNLNQNIGA 291
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
27-301 |
2.51e-22 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 95.83 E-value: 2.51e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 27 TSAAVTRAFLERGHTEIDTAFLYSD--GQSETILGGLgLRMGSSDCR--VKIATKA--NPWIGNSLKPDSVR---SQLET 97
Cdd:PRK09912 44 SQRAILRKAFDLGITHFDLANNYGPppGSAEENFGRL-LREDFAAYRdeLIISTKAgyDMWPGPYGSGGSRKyllASLDQ 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 98 SLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSngWILP-TVYQGMYSATT 176
Cdd:PRK09912 123 SLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQSGKALYVGISSYSPERTQKMVELLRE--WKIPlLIHQPSYNLLN 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 177 RQVE-TELFPCLRHFGLRFYAYNPLAGGLLTGKY-------KYEDKDGKQPVGrffgtqwaeiYRNHFWKEHHFEGIALV 248
Cdd:PRK09912 201 RWVDkSGLLDTLQNNGVGCIAFTPLAQGLLTGKYlngipqdSRMHREGNKVRG----------LTPKMLTEANLNSLRLL 270
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1139695540 249 EKALQaaygASAPSMTSAALRWMYHHSQLQgahgdAVILGMSSLEQLEQNLAA 301
Cdd:PRK09912 271 NEMAQ----QRGQSMAQMALSWLLKDERVT-----SVLIGASRAEQLEENVQA 314
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
31-301 |
5.24e-22 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 94.05 E-value: 5.24e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 31 VTRAFlERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVKIATKANpWIGNS-----LKPDSVRSQLETSLKRLQCP 105
Cdd:cd19141 36 VTLAY-ENGINLFDTAEVYAAGKAEIVLGKILKKKGWRRSSYVITTKIF-WGGKAetergLSRKHIIEGLKASLERLQLE 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 106 RVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTR-QVETELf 184
Cdd:cd19141 114 YVDIVFANRPDPNTPMEEIVRAFTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNLIPPIVEQAEYHLFQReKVEMQL- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 185 PCLRH-FGLRFYAYNPLAGGLLTGKYkyedKDGKQPVGR--FFGTQW------AEIYRNHFWKEHHFEGIAlvEKalqaa 255
Cdd:cd19141 193 PELFHkIGVGAMTWSPLACGILSGKY----DDGVPEYSRasLKGYQWlkekilSEEGRRQQAKLKELQIIA--DR----- 261
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1139695540 256 YGASAPSMTSAalrWMYHHsqlQGAHGdaVILGMSSLEQLEQNLAA 301
Cdd:cd19141 262 LGCTLPQLAIA---WCLKN---EGVSS--VLLGASSTEQLYENLQA 299
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
10-205 |
3.44e-21 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 91.16 E-value: 3.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 10 PATVLGAMEMG-RRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLgLRmGSSDcRVKIATKANPWigNSlKP 88
Cdd:cd19138 12 PALGQGTWYMGeDPAKRAQEIEALRAGIDLGMTLIDTAEMYGDGGSEELVGEA-IR-GRRD-KVFLVSKVLPS--NA-SR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 89 DSVRSQLETSLKRLQCPRVDLFYLHAPDhSAPVEETLRACHQLHQEGKFVELGLSNYaawEVAEICTLCKSNGWILPTVY 168
Cdd:cd19138 86 QGTVRACERSLRRLGTDYLDLYLLHWRG-GVPLAETVAAMEELKKEGKIRAWGVSNF---DTDDMEELWAVPGGGNCAAN 161
|
170 180 190
....*....|....*....|....*....|....*...
gi 1139695540 169 QGMYSATTRQVETELFPCLRHFGLRFYAYNPLA-GGLL 205
Cdd:cd19138 162 QVLYNLGSRGIEYDLLPWCREHGVPVMAYSPLAqGGLL 199
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
14-320 |
1.44e-20 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 91.03 E-value: 1.44e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMemgR--RMDAPTSAAVTRAFLERGHTEIDTAFLYsdGQSETILG-GL-GLRmgssDcRVKIATKANPWIGNslkPD 89
Cdd:COG1453 18 FGGM---RlpRKDEEEAEALIRRAIDNGINYIDTARGY--GDSEEFLGkALkGPR----D-KVILATKLPPWVRD---PE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 90 SVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLR------ACHQLHQEGKFVELGLSNYAAWEVAEicTLCKSNGW- 162
Cdd:COG1453 85 DMRKDLEESLKRLQTDYIDLYLIHGLNTEEDLEKVLKpggaleALEKAKAEGKIRHIGFSTHGSLEVIK--EAIDTGDFd 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 163 -ILPTVYqgmYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTgkykyedkDGKQPVGRFFGTQWaeiyrnhfwkehh 241
Cdd:COG1453 163 fVQLQYN---YLDQDNQAGEEALEAAAEKGIGVIIMKPLKGGRLA--------NPPEKLVELLCPPL------------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 242 fegialvekalqaaygasapSMTSAALRWMYHHSQLqgahgDAVILGMSSLEQLEQNLAAAEEG-PL---EPAVVDAFNQ 317
Cdd:COG1453 219 --------------------SPAEWALRFLLSHPEV-----TTVLSGMSTPEQLDENLKTADNLePLteeELAILERLAE 273
|
...
gi 1139695540 318 AWH 320
Cdd:COG1453 274 ELG 276
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
20-306 |
2.28e-19 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 87.06 E-value: 2.28e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 20 GRRMDAPTSAAVTRAFlERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVKIATKANpWIGNS-----LKPDSVRSQ 94
Cdd:cd19158 26 GQITDEMAEHLMTLAY-DNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIF-WGGKAetergLSRKHIIEG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 95 LETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSA 174
Cdd:cd19158 104 LKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLIPPICEQAEYHM 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 175 TTRQ-VETELFPCLRHFGLRFYAYNPLAGGLLTGKYkyedKDGKQPVGR--FFGTQWaeiYRNHFWKEHHFEGIALVeKA 251
Cdd:cd19158 184 FQREkVEVQLPELFHKIGVGAMTWSPLACGIVSGKY----DSGIPPYSRasLKGYQW---LKDKILSEEGRRQQAKL-KE 255
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1139695540 252 LQAAYGASAPSMTSAALRWMyhhsqLQGAHGDAVILGMSSLEQLEQNLAAAEEGP 306
Cdd:cd19158 256 LQAIAERLGCTLPQLAIAWC-----LRNEGVSSVLLGASNAEQLMENIGAIQVLP 305
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
14-305 |
3.19e-19 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 85.31 E-value: 3.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMEM----GRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLgLRMGSSDcRVKIATKANPWIGNSlkPD 89
Cdd:cd19096 5 FGTMRLpesdDDSIDEEKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEA-LKEGPRE-KFYLATKLPPWSVKS--AE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 90 SVRSQLETSLKRLQCPRVDLFYLHAPDHSApVEETLRACH------QLHQEGKFVELGLSNYAAWEVaeICTLCKSNGW- 162
Cdd:cd19096 81 DFRRILEESLKRLGVDYIDFYLLHGLNSPE-WLEKARKGGllefleKAKKEGLIRHIGFSFHDSPEL--LKEILDSYDFd 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 163 -------ILPTVYQGMYSAttrqveteLFPCLRHfGLRFYAYNPLAGGLLTgkykyedkdgkqpvgrffgtqwaeiyrnh 235
Cdd:cd19096 158 fvqlqynYLDQENQAGRPG--------IEYAAKK-GMGVIIMEPLKGGGLA----------------------------- 199
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 236 fwkehhfegiALVEKALQAAYGASAPSMtSAALRWMYHHsqlQGAHgdAVILGMSSLEQLEQNLAAAEEG 305
Cdd:cd19096 200 ----------NNPPEALAILCGAPLSPA-EWALRFLLSH---PEVT--TVLSGMSTPEQLDENIAAADEF 253
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
37-306 |
4.35e-19 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 86.25 E-value: 4.35e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 37 ERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVKIATKANpWIGNS-----LKPDSVRSQLETSLKRLQCPRVDLFY 111
Cdd:cd19159 42 ESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLY-WGGKAetergLSRKHIIEGLKGSLQRLQLEYVDVVF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 112 LHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQ-VETELfPCLRH- 189
Cdd:cd19159 121 ANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREkVEVQL-PELYHk 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 190 FGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFgtQW------AEIYRNHFWKEHHFEGIAlvEKalqaaYGASAPSM 263
Cdd:cd19159 200 IGVGAMTWSPLACGIISGKYGNGVPESSRASLKCY--QWlkerivSEEGRKQQNKLKDLSPIA--ER-----LGCTLPQL 270
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1139695540 264 tsaALRWMyhhsqLQGAHGDAVILGMSSLEQLEQNLAAAEEGP 306
Cdd:cd19159 271 ---AVAWC-----LRNEGVSSVLLGSSTPEQLIENLGAIQVLP 305
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
24-317 |
4.54e-19 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 86.19 E-value: 4.54e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 24 DAPTSAAVTRAFlERGHTEIDTAFLYSDGQSETILGGL----GLRMGSSDCRVKIATKANPWIGNSLKPDSVRSQLETSL 99
Cdd:cd19160 32 DETAEDLLTVAY-EHGVNLFDTAEVYAAGKAERTLGNIlkskGWRRSSYVVTTKIYWGGQAETERGLSRKHIIEGLRGSL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 100 KRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQ- 178
Cdd:cd19160 111 DRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQGMAMYWGTSRWSAMEIMEAYSVARQFNLIPPVCEQAEYHLFQREk 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 179 VETELfPCLRH-FGLRFYAYNPLAGGLLTGkyKYEDKDGKQPVGRFFGTQW-AEIYRNHFWKEHHfegiALVEKALQAAY 256
Cdd:cd19160 191 VEMQL-PELYHkIGVGSVTWSPLACGLITG--KYDGRVPDTCRAAVKGYQWlKEKVQSEEGKKQQ----AKVKELHPIAD 263
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1139695540 257 GASApSMTSAALRWMyhhsqLQGAHGDAVILGMSSLEQLEQNLAAAEE-GPLEPAVVDAFNQ 317
Cdd:cd19160 264 RLGC-TVAQLAIAWC-----LRSEGVSSVLLGVSSAEQLIENLGSIQVlSQLTPQTVMEIDA 319
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
29-303 |
7.65e-19 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 84.24 E-value: 7.65e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 29 AAVTRAFLERGHTEIDTAFLYsDGQSETilgGLGLRmGSSDCR--VKIATKAnpWIGNsLKPDSVRSQLETSLKRLQCPR 106
Cdd:cd19073 17 ANAVKEALELGYRHIDTAEIY-NNEAEV---GEAIA-ESGVPRedLFITTKV--WRDH-LRPEDLKKSVDRSLEKLGTDY 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 107 VDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEictlCKSNGWILPTVYQGMYSATTRQVETELFpC 186
Cdd:cd19073 89 VDLLLIHWPNPTVPLEETLGALKELKEAGKVKSIGVSNFTIELLEE----ALDISPLPIAVNQVEFHPFLYQAELLEY-C 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 187 LRHfGLRFYAYNPLAGGlltgkykyedkdgkqpvgrffgtqwaEIYRNHfwkehhfegialVEKALQAAYGASaPSMTsa 266
Cdd:cd19073 164 REN-DIVITAYSPLARG--------------------------EVLRDP------------VIQEIAEKYDKT-PAQV-- 201
|
250 260 270
....*....|....*....|....*....|....*..
gi 1139695540 267 ALRWMYhhsqlqgAHGDAVILGMSSLEQLEQNLAAAE 303
Cdd:cd19073 202 ALRWLV-------QKGIVVIPKASSEDHLKENLAIFD 231
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
15-266 |
1.02e-18 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 84.69 E-value: 1.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 15 GAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDcrVKIATKANPwIGNSLKPDSVRSQ 94
Cdd:cd19103 21 GDQVFGNHLDEDTLKAVFDKAMAAGLNLWDTAAVYGMGASEKILGEFLKRYPRED--YIISTKFTP-QIAGQSADPVADM 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 95 LETSLKRLQCPRVDLFYLHAPdhsAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVyQGMYSA 174
Cdd:cd19103 98 LEGSLARLGTDYIDIYWIHNP---ADVERWTPELIPLLKSGKVKHVGVSNHNLAEIKRANEILAKAGVSLSAV-QNHYSL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 175 TTRQVETE--LFPCLRHfGLRFYAYNPLAGGLLTGKYkyedkDGKQPVGRffGTQWAEIYRNhfwKEHHFEGIALVEKAL 252
Cdd:cd19103 174 LYRSSEEAgiLDYCKEN-GITFFAYMVLEQGALSGKY-----DTKHPLPE--GSGRAETYNP---LLPQLEELTAVMAEI 242
|
250
....*....|....
gi 1139695540 253 QAAYGASAPSMTSA 266
Cdd:cd19103 243 GAKHGASIAQVAIA 256
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
13-303 |
1.51e-18 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 84.14 E-value: 1.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 13 VLGAMemgRRMDAPTSAAVTRAF----LERGHTEIDTAFLYSDGQSETILG-GLGLRMGSSDcRVKIATKA--------N 79
Cdd:cd19092 10 VLGCM---RLADWGESAEELLSLieaaLELGITTFDHADIYGGGKCEELFGeALALNPGLRE-KIEIQTKCgirlgddpR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 80 PWIGNS--LKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVA------ 151
Cdd:cd19092 86 PGRIKHydTSKEHILASVEGSLKRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELVKSGKVRYFGVSNFTPSQIEllqsyl 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 152 ---------EICTLCksngwiLPTVYQGMysattrqveteLFPCLRHfGLRFYAYNPLAGglltgkykyedkdgkqpvGR 222
Cdd:cd19092 166 dqplvtnqiELSLLH------TEAIDDGT-----------LDYCQLL-DITPMAWSPLGG------------------GR 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 223 FFGTQWAEIYRnhfwkehhfegIALVEKALQAAYGASApsmTSAALRW-MYHHSQLQgahgdaVILGMSSLEQLEQNLAA 301
Cdd:cd19092 210 LFGGFDERFQR-----------LRAALEELAEEYGVTI---EAIALAWlLRHPARIQ------PILGTTNPERIRSAVKA 269
|
..
gi 1139695540 302 AE 303
Cdd:cd19092 270 LD 271
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
20-303 |
3.12e-18 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 83.41 E-value: 3.12e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 20 GRRMDAPTSAAVT--RAFLERGHTEIDTAFLYsdGQSETILGGLGLRM---GSSDCRVKIATKANPWIGN-SLKPDSVRS 93
Cdd:cd19101 15 GHGGIRDEDAAVRamAAYVDAGLTTFDCADIY--GPAEELIGEFRKRLrreRDAADDVQIHTKWVPDPGElTMTRAYVEA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 94 QLETSLKRLQCPRVDLFYLHAPDHSAP-VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICtlckSNGwiLPTVY-QGM 171
Cdd:cd19101 93 AIDRSLKRLGVDRLDLVQFHWWDYSDPgYLDAAKHLAELQEEGKIRHLGLTNFDTERLREIL----DAG--VPIVSnQVQ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 172 YSATTRQVETELFP-CLRHfGLRFYAYNPLAGGLLTGKYkyedKDGKQPVGRFFGTQWAEIYRNHFwkeHHFEGIALVEK 250
Cdd:cd19101 167 YSLLDRRPENGMAAlCEDH-GIKLLAYGTLAGGLLSEKY----LGVPEPTGPALETRSLQKYKLMI---DEWGGWDLFQE 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1139695540 251 ALQA------AYGAsapSMTSAALRWMyhhsqLQGAHGDAVILGMSSLEQLEQNLAAAE 303
Cdd:cd19101 239 LLRTlkaiadKHGV---SIANVAVRWV-----LDQPGVAGVIVGARNSEHIDDNVRAFS 289
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-302 |
7.85e-18 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 81.48 E-value: 7.85e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMEMGRRmdaptSAAVTRAFLERGHTEIDTAFLYSDGQSETILGGlGLRMGSSDcRVKIATKANPWiGNSLKPDSVRS 93
Cdd:cd19105 18 FGGGGLPRE-----SPELLRRALDLGINYFDTAEGYGNGNSEEIIGE-ALKGLRRD-KVFLATKASPR-LDKKDKAELLK 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 94 QLETSLKRLQCPRVDLFYLHAPDHSAP---VEETLRACHQLHQEGKFVELGLS-NYAAWEVAEicTLCKSnGWIlpTVYQ 169
Cdd:cd19105 90 SVEESLKRLQTDYIDIYQLHGVDTPEErllNEELLEALEKLKKEGKVRFIGFStHDNMAEVLQ--AAIES-GWF--DVIM 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 170 GMYSATTRQVE-TELFP-CLRHfGLRFYAYNPLAGGLLTGKYKYEDKdgkqpvgrffgtqwaeiyrnhfwkehhfegial 247
Cdd:cd19105 165 VAYNFLNQPAElEEALAaAAEK-GIGVVAMKTLAGGYLQPALLSVLK--------------------------------- 210
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1139695540 248 vekalqaaygASAPSMTSAALRWMYHHSQLqgahgDAVILGMSSLEQLEQNLAAA 302
Cdd:cd19105 211 ----------AKGFSLPQAALKWVLSNPRV-----DTVVPGMRNFAELEENLAAA 250
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
24-303 |
8.76e-18 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 81.25 E-value: 8.76e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 24 DAPTSAAVTRAfLERGHTEIDTAFLYsdgQSETILGgLGLRmgSSDCR---VKIATKAnpWIGNsLKPDSVRSQLETSLK 100
Cdd:COG0656 17 GEEAAAAVRTA-LEAGYRHIDTAAMY---GNEEGVG-EAIA--ASGVPreeLFVTTKV--WNDN-HGYDDTLAAFEESLE 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 101 RLQCPRVDLFYLHAPDHsAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQGMYSATTRQve 180
Cdd:COG0656 87 RLGLDYLDLYLIHWPGP-GPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETG----VKPAVNQVELHPYLQQ-- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 181 TELFPCLRHFGLRFYAYNPLA-GGLLtgkykyedkdgKQPVgrffgtqwaeiyrnhfwkehhFEGIAlvekalqAAYGAS 259
Cdd:COG0656 160 RELLAFCREHGIVVEAYSPLGrGKLL-----------DDPV---------------------LAEIA-------EKHGKT 200
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1139695540 260 APsmtSAALRWmyhHSQlqgaHGDAVILGMSSLEQLEQNLAAAE 303
Cdd:COG0656 201 PA---QVVLRW---HLQ----RGVVVIPKSVTPERIRENLDAFD 234
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
33-307 |
3.00e-17 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 80.26 E-value: 3.00e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 33 RAFLERGHTEIDTAFLYsdGQSETILGGLGLRMGssdcRVKIATK--ANPWIGNSLKpDSVRSQLETSLKRLQCPRVDLF 110
Cdd:cd19097 33 EYALKAGINTLDTAPAY--GDSEKVLGKFLKRLD----KFKIITKlpPLKEDKKEDE-AAIEASVEASLKRLKVDSLDGL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 111 YLHAPD----HSAPVEETLRachQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwilPTVYQGMYSA-TTRQVETELFP 185
Cdd:cd19097 106 LLHNPDdllkHGGKLVEALL---ELKKEGLIRKIGVSVYSPEELEKALESFK------IDIIQLPFNIlDQRFLKSGLLA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 186 CLRHFGLRFYAYNPLAGGLLTgkykyedKDGKQPVGRFFgtqwaeiyrnhFWKEHH--FEGIAlvekalqAAYGASAPSM 263
Cdd:cd19097 177 KLKKKGIEIHARSVFLQGLLL-------MEPDKLPAKFA-----------PAKPLLkkLHELA-------KKLGLSPLEL 231
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1139695540 264 tsaALRWMYHHSqlqgaHGDAVILGMSSLEQLEQNLAAAEEGPL 307
Cdd:cd19097 232 ---ALGFVLSLP-----EIDKIVVGVDSLEQLKEIIAAFKKPPL 267
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
14-301 |
9.58e-17 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 78.43 E-value: 9.58e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMEMGR---RMDAPTSAAVTRAFLERGHTEIDTAFLYsdGQSETILGGLgLRMGSSDcRVKIATKA-----NPWIGNS 85
Cdd:cd19095 5 LGTSGIGRvwgVPSEAEAARLLNTALDLGINLIDTAPAY--GRSEERLGRA-LAGLRRD-DLFIATKVgthgeGGRDRKD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 86 LKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAawevAEICTLCKSNgwiLP 165
Cdd:cd19095 81 FSPAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVLETLEDLKAAGKVRYIGVSGDG----EELEAAIASG---VF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 166 TVYQGMYSATTRQVEtELFPCLRHFGLRFYAYNPLAGGLLtgkykyedkdgkqpvgrffgtqwaeiyrnhFWKEHHFEGI 245
Cdd:cd19095 154 DVVQLPYNVLDREEE-ELLPLAAEAGLGVIVNRPLANGRL------------------------------RRRVRRRPLY 202
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1139695540 246 ALVEKALQAAYGASAPSMTSAALRWMYHHSQLqgahgDAVILGMSSLEQLEQNLAA 301
Cdd:cd19095 203 ADYARRPEFAAEIGGATWAQAALRFVLSHPGV-----SSAIVGTTNPEHLEENLAA 253
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
27-203 |
1.27e-16 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 77.91 E-value: 1.27e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 27 TSAAVTRAfLERGHTEIDTAFLYsdgQSETILGgLGLRmgssDCRVK-----IATKANPwigNSLKPDSVRSQLETSLKR 101
Cdd:cd19071 16 TAEAVLAA-LEAGYRHIDTAAAY---GNEAEVG-EAIR----ESGVPreelfITTKLWP---TDHGYERVREALEESLKD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 102 LQCPRVDLFYLHAP------DHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQGMYSAT 175
Cdd:cd19071 84 LGLDYLDLYLIHWPvpgkegGSKEARLETWRALEELVDEGLVRSIGVSNFNVEHLEELLAAAR----IKPAVNQIELHPY 159
|
170 180
....*....|....*....|....*...
gi 1139695540 176 TRQVETELFpCLRHfGLRFYAYNPLAGG 203
Cdd:cd19071 160 LQQKELVEF-CKEH-GIVVQAYSPLGRG 185
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
27-301 |
1.56e-16 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 78.65 E-value: 1.56e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 27 TSAAVTRAFLERGHTEIDTAFLYSD--GQSETILGGLgLRMGSSDCR--VKIATKA--NPWIG-----NSLKpdSVRSQL 95
Cdd:cd19150 31 TQRAILRTAFDLGITHFDLANNYGPppGSAEENFGRI-LREDFAGYRdeLIISTKAgyDMWPGpygewGSRK--YLLASL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 96 ETSLKRLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILpTVYQGMYSAT 175
Cdd:cd19150 108 DQSLKRMGLDYVDIFYSHRFDPDTPLEETMGALDHAVRSGKALYVGISSYSPERTREAAAILRELGTPL-LIHQPSYNML 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 176 TRQVE-TELFPCLRHFGLRFYAYNPLAGGLLTGKYKyedkdGKQPVGRffgtqwaeiyRNHfwKEHHFEGIALVE----- 249
Cdd:cd19150 187 NRWVEeSGLLDTLQELGVGCIAFTPLAQGLLTDKYL-----NGIPEGS----------RAS--KERSLSPKMLTEanlns 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1139695540 250 -KALQAAYGASAPSMTSAALRWMyhhsqLQGAHGDAVILGMSSLEQLEQNLAA 301
Cdd:cd19150 250 iRALNEIAQKRGQSLAQMALAWV-----LRDGRVTSALIGASRPEQLEENVGA 297
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
14-221 |
3.16e-16 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 78.36 E-value: 3.16e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLY-------SDGQSETILGGLGLRMGSSDcRVKIATK-ANPWIGN- 84
Cdd:PRK10625 18 LGTMTFGEQNSEADAHAQLDYAVAQGINLIDVAEMYpvpprpeTQGLTETYIGNWLAKRGSRE-KLIIASKvSGPSRNNd 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 85 -SLKPD------SVRSQLETSLKRLQCPRVDLFYLHAP---------------DHSAPVE--ETLRACHQLHQEGKFVEL 140
Cdd:PRK10625 97 kGIRPNqaldrkNIREALHDSLKRLQTDYLDLYQVHWPqrptncfgklgyswtDSAPAVSllETLDALAEQQRAGKIRYI 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 141 GLSNYAAWEVAEICTLCKSNGwiLPTVY--QGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYkyedKDGKQ 218
Cdd:PRK10625 177 GVSNETAFGVMRYLHLAEKHD--LPRIVtiQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLAFGTLTGKY----LNGAK 250
|
...
gi 1139695540 219 PVG 221
Cdd:PRK10625 251 PAG 253
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
33-205 |
1.98e-15 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 74.91 E-value: 1.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 33 RAFLERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDcrVKIATKANPwigNSLKPDSVRSQLETSLKRLQCPRVDLFYL 112
Cdd:cd19137 33 KTAIELGYTHIDTAEMYGGGHTEELVGKAIKDFPRED--LFIVTKVWP---TNLRYDDLLRSLQNSLRRLDTDYIDLYLI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 113 HAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSngwilPTVY-QGMYSATTRQVETE-LFPCLRHF 190
Cdd:cd19137 108 HWPNPNIPLEETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAISKSQT-----PIVCnQVKYNLEDRDPERDgLLEYCQKN 182
|
170
....*....|....*
gi 1139695540 191 GLRFYAYNPLAGGLL 205
Cdd:cd19137 183 GITVVAYSPLRRGLE 197
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
29-308 |
2.43e-13 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 69.12 E-value: 2.43e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 29 AAVTRAfLERGHTEIDTAFLYSDGQSETILGgLGLRMGSSDcRVKIATKA-----NPWIGNSLKPDSVRSQLETSLKRLQ 103
Cdd:cd19163 37 RTVHEA-LDSGINYIDTAPWYGQGRSETVLG-KALKGIPRD-SYYLATKVgryglDPDKMFDFSAERITKSVEESLKRLG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 104 CPRVDLFYLH----APDHSAPVEETLRACHQLHQEGKFVELGLSNY--AAW-EVAE--------ICTLCKsngwilptvy 168
Cdd:cd19163 114 LDYIDIIQVHdiefAPSLDQILNETLPALQKLKEEGKVRFIGITGYplDVLkEVLErspvkidtVLSYCH---------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 169 qgmYSATTRQVeTELFPCLRHFGLRFYAYNPLAGGLLTgkykyedKDGKQPvgrffgtqwaeiyrnhfWKEHHFEGIALV 248
Cdd:cd19163 184 ---YTLNDTSL-LELLPFFKEKGVGVINASPLSMGLLT-------ERGPPD-----------------WHPASPEIKEAC 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1139695540 249 EKAlqAAYGASAPSMTSA-ALRWMYHHSQLqgahgDAVILGMSSLEQLEQNLAAAEEGPLE 308
Cdd:cd19163 236 AKA--AAYCKSRGVDISKlALQFALSNPDI-----ATTLVGTASPENLRKNLEAAEEPLDA 289
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
14-300 |
2.93e-13 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 68.28 E-value: 2.93e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMEMGRrMDAPTSAAVTRAFLERGHTEIDTAFLYsdGQSETILGgLGLRmgssDCR--VKIATKANPWignslKPDSV 91
Cdd:cd19100 16 FGGGPLGR-LSQEEAAAIIRRALDLGINYFDTAPSY--GDSEEKIG-KALK----GRRdkVFLATKTGAR-----DYEGA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 92 RSQLETSLKRLQCPRVDLFYLHAPDHSAPVEET------LRACHQLHQEGKFVELGLS---NYAAWEVAEictlcksNGW 162
Cdd:cd19100 83 KRDLERSLKRLGTDYIDLYQLHAVDTEEDLDQVfgpggaLEALLEAKEEGKIRFIGISghsPEVLLRALE-------TGE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 163 ---ILPTVyqGMYSATTRQVETELFP-CLRHfGLRFYAYNPLAGGLLTGKyKYEDKDgkqpvgrffgtqwaeiyrnhfwk 238
Cdd:cd19100 156 fdvVLFPI--NPAGDHIDSFREELLPlAREK-GVGVIAMKVLAGGRLLSG-DPLDPE----------------------- 208
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1139695540 239 ehhfegialvekalqaaygasapsmtsAALRWMyhhsqLQGAHGDAVILGMSSLEQLEQNLA 300
Cdd:cd19100 209 ---------------------------QALRYA-----LSLPPVDVVIVGMDSPEELDENLA 238
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
19-319 |
3.84e-13 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 68.83 E-value: 3.84e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 19 MGRRMDAPTSAAVTRAfLERGHTEIDTAFLYSDGQSETILGGLgLRmGSSDcRVKIATKANpwIGNSLKPD---SVRSQL 95
Cdd:cd19104 26 MGRTTREEQIAAVRRA-LDLGINFFDTAPSYGDGKSEENLGRA-LK-GLPA-GPYITTKVR--LDPDDLGDiggQIERSV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 96 ETSLKRLQCPRVDLFYLH---------------APDHSAPVEETLRACHQLHQEGKFVELGLSnyaAWEVAE-ICTLCKS 159
Cdd:cd19104 100 EKSLKRLKRDSVDLLQLHnrigderdkpvggtlSTTDVLGLGGVADAFERLRSEGKIRFIGIT---GLGNPPaIRELLDS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 160 NGW---------ILPTVYQGMYSATTRQVETELFP-CLRHfGLRFYAYNPLAGGLLTGKykyEDKDGKQPvgrffgtqwa 229
Cdd:cd19104 177 GKFdavqvyynlLNPSAAEARPRGWSAQDYGGIIDaAAEH-GVGVMGIRVLAAGALTTS---LDRGREAP---------- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 230 eiyrnHFWKEHHFEGIALVeKALQAAYGASAPSMTSAALRWMYHHSQLqgahgDAVILGMSSLEQLEQNLAAAEEGPLEP 309
Cdd:cd19104 243 -----PTSDSDVAIDFRRA-AAFRALAREWGETLAQLAHRFALSNPGV-----STVLVGVKNREELEEAVAAEAAGPLPA 311
|
330
....*....|
gi 1139695540 310 AVVDAFNQAW 319
Cdd:cd19104 312 ENLARLEALW 321
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
14-303 |
1.31e-12 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 67.26 E-value: 1.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 14 LGAMEMGRRMDAPTSA---AVTRAFLERGHTEIDTAFLYSdgqSETILGGLGL-------RMGSSDcRVKIATKANpWIG 83
Cdd:cd19077 10 LGLMGLTWRPNPTPDEeafETMKAALDAGSNLWNGGEFYG---PPDPHANLKLlarffrkYPEYAD-KVVLSVKGG-LDP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 84 NSLKPDS----VRSQLETSLKRLQCP-RVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSnyaawEV-AEicTLC 157
Cdd:cd19077 85 DTLRPDGspeaVRKSIENILRALGGTkKIDIFEPARVDPNVPIEETIKALKELVKEGKIRGIGLS-----EVsAE--TIR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 158 KSNGWILPTVYQGMYSATTRQVET-ELFPCLRHFGLRFYAYNPLAGGLLTGKYKYED----KDGKQPVGRFFGTQWAEIy 232
Cdd:cd19077 158 RAHAVHPIAAVEVEYSLFSREIEEnGVLETCAELGIPIIAYSPLGRGLLTGRIKSLAdipeGDFRRHLDRFNGENFEKN- 236
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1139695540 233 rnhfwkehhfegIALVEkALQAAygASAPSMTSA--ALRWMYHHSqlqgahGDAV--ILGMSSLEQLEQNLAAAE 303
Cdd:cd19077 237 ------------LKLVD-ALQEL--AEKKGCTPAqlALAWILAQS------GPKIipIPGSTTLERVEENLKAAN 290
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
29-301 |
2.50e-12 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 66.72 E-value: 2.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 29 AAVTRAFlERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVKIATKANpWIGNS----LKPDSVRSQLETSLKRLQC 104
Cdd:cd19142 35 EIVTLAY-ENGINYFDTSDAFTSGQAETELGRILKKKGWKRSSYIVSTKIY-WSYGSeergLSRKHIIESVRASLRRLQL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 105 PRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQ-VETEL 183
Cdd:cd19142 113 DYIDIVIIHKADPMCPMEEVVRAMSYLIDNGLIMYWGTSRWSPVEIMEAFSIARQFNCPTPICEQSEYHMFCREkMELYM 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 184 FPCLRHFGLRFYAYNPLAGGLLTGK--------YKYEDKDGKQPVGRFFGTQWAEIYRNHfwkEHHFEGIALVEKalqaa 255
Cdd:cd19142 193 PELYNKVGVGLITWSPLSLGLDPGIseetrrlvTKLSFKSSKYKVGSDGNGIHEETRRAS---HKLRELSLIAER----- 264
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1139695540 256 YGAsapSMTSAALRWmyhhsQLQGAHGDAVILGMSSLEQLEQNLAA 301
Cdd:cd19142 265 LGC---DLTQLLIAW-----SLKNENVQCVLIGASSLEQLYSQLNS 302
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
21-300 |
3.69e-12 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 65.36 E-value: 3.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 21 RRMDAPTSAAVTRAFLERGHTEIDTAFLYsdgQSETILGGLGLRMGSSDCRVKIATKAnpWIGNSLKPDSVRSqLETSLK 100
Cdd:cd19140 16 YPLTGEECTRAVEHALELGYRHIDTAQMY---GNEAQVGEAIAASGVPRDELFLTTKV--WPDNYSPDDFLAS-VEESLR 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 101 RLQCPRVDLFYLHAPDHSAPVEETLRACHQLHQEGKFVELGLSNY------AAWEVAEICTLCKsngwilptvyQGMYSA 174
Cdd:cd19140 90 KLRTDYVDLLLLHWPNKDVPLAETLGALNEAQEAGLARHIGVSNFtvallrEAVELSEAPLFTN----------QVEYHP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 175 TTRQveTELFPCLRHFGLRFYAYNPLAGGLLTgkykyedkdgKQPVgrffgtqwaeiyrnhfwkehhFEGIAlvekalqA 254
Cdd:cd19140 160 YLDQ--RKLLDAAREHGIALTAYSPLARGEVL----------KDPV---------------------LQEIG-------R 199
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1139695540 255 AYGASApsmTSAALRWMyhhsqLQGAhGDAVILGMSSLEQLEQNLA 300
Cdd:cd19140 200 KHGKTP---AQVALRWL-----LQQE-GVAAIPKATNPERLEENLD 236
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
33-300 |
4.95e-12 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 65.80 E-value: 4.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 33 RAFLERGHTEIDTAFLYSDGQSETILGGLgLRMGSSDCRVK-----IATKA-------------NPWIGN---------- 84
Cdd:cd19099 28 KAALDSGINVIDTAINYRGGRSERLIGKA-LRELIEKGGIKrdevvIVTKAgyipgdgdeplrpLKYLEEklgrglidva 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 85 -------SLKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPV----------EETLRACHQLHQEGK----------- 136
Cdd:cd19099 107 dsaglrhCISPAYLEDQIERSLKRLGLDTIDLYLLHNPEEQLLElgeeefydrlEEAFEALEEAVAEGKiryygistwdg 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 137 ---------FVELGLSNYAAWEVAE----------ICTLCKSNGWILPTVYQGMYsattrqveTELFPCLRHFGLRFYAY 197
Cdd:cd19099 187 frappalpgHLSLEKLVAAAEEVGGdnhhfkviqlPLNLLEPEALTEKNTVKGEA--------LSLLEAAKELGLGVIAS 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 198 NPLAGGLLTGKykyedkdgkqpvgrffgtqwaeiyRNHFWKEHHFEGIALVEKALQAAygASAPSMTSaalrwmyhhsql 277
Cdd:cd19099 259 RPLNQGQLLGE------------------------LRLADLLALPGGATLAQRALQFA--RSTPGVDS------------ 300
|
330 340
....*....|....*....|...
gi 1139695540 278 qgahgdaVILGMSSLEQLEQNLA 300
Cdd:cd19099 301 -------ALVGMRRPEHVDENLA 316
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
28-158 |
1.60e-11 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 64.06 E-value: 1.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 28 SAAVTRAfLERGHTEIDTAFLYsdgQSETILGGLgLRMGSSDCRVK-----IATKAnPWIGNSlkPDSVRSQLETSLKRL 102
Cdd:cd19111 20 RAAVDYA-LFVGYRHIDTALSY---QNEKAIGEA-LKWWLKNGKLKreevfITTKL-PPVYLE--FKDTEKSLEKSLENL 91
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1139695540 103 QCPRVDLFYLHAP-------------DHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCK 158
Cdd:cd19111 92 KLPYVDLYLIHHPcgfvnkkdkgereLASSDVTSVWRAMEALVSEGKVKSIGLSNFNPRQINKILAYAK 160
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
30-206 |
3.37e-11 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 62.65 E-value: 3.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 30 AVTRAFLERGHTEIDTAFLYsdgQSE----TILGGLGLRMGSSDCRVKIATKANPwigNSLKPDSVRSQLETSLKRLQCP 105
Cdd:cd19136 19 QAVDAALKAGYRLIDTASVY---RNEadigKALRDLLPKYGLSREDIFITSKLAP---KDQGYEKARAACLGSLERLGTD 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 106 RVDLFYLHAP-----DHSAPVE-----ETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQGMYSAt 175
Cdd:cd19136 93 YLDLYLIHWPgvqglKPSDPRNaelrrESWRALEDLYKEGKLRAIGVSNYTVRHLEELLKYCE----VPPAVNQVEFHP- 167
|
170 180 190
....*....|....*....|....*....|.
gi 1139695540 176 tRQVETELFPCLRHFGLRFYAYNPLAGGLLT 206
Cdd:cd19136 168 -HLVQKELLKFCKDHGIHLQAYSSLGSGDLR 197
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
10-303 |
1.34e-10 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 61.47 E-value: 1.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 10 PATVLGAMEMG---RRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILGgLGLRMGSSDcRVKIATKAN------- 79
Cdd:cd19152 1 PKLGFGTAPLGnlyEAVSDEEAKATLVAAWDLGIRYFDTAPWYGAGLSEERLG-AALRELGRE-DYVISTKVGrllvplq 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 80 ---------PWIGNSLKP------DSVRSQLETSLKRLQCPRVDLFYLHAPD---HSAPVEETL--------RACHQLHQ 133
Cdd:cd19152 79 eveptfepgFWNPLPFDAvfdysyDGILRSIEDSLQRLGLSRIDLLSIHDPDedlAGAESDEHFaqaikgafRALEELRE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 134 EGKFVELGL-SNyaAWEVAE-ICTLCKSNgWILptvYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTG---- 207
Cdd:cd19152 159 EGVIKAIGLgVN--DWEVILrILEEADLD-WVM---LAGRYTLLDHSAARELLPECEKRGVKVVNAGPFNSGFLAGgdnf 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 208 -KYKYEDKDGKQPVGRffgTQWAEIYRNHfwkehhfeGIALVEKALQAAYGASAPSmtsaalrwmyhhsqlqgahgdAVI 286
Cdd:cd19152 233 dYYEYGPAPPELIARR---DRIEALCEQH--------GVSLAAAALQFALAPPAVA---------------------SVA 280
|
330
....*....|....*..
gi 1139695540 287 LGMSSLEQLEQNLAAAE 303
Cdd:cd19152 281 PGASSPERVEENVALLA 297
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
10-301 |
4.20e-10 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 59.29 E-value: 4.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 10 PATVLGAmemGRRMDAPTSAAVTRAfLERGHTEIDTAFLYsDGQSETilgGLGLRmgssDCRVK-----IATKAnpWIGN 84
Cdd:cd19139 2 PAFGLGT---FRLKDDVVIDSVRTA-LELGYRHIDTAQIY-DNEAAV---GQAIA----ESGVPrdelfITTKI--WIDN 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 85 sLKPDSVRSQLETSLKRLQCPRVDLFYLH--APDHSAPVEETLRACHQLHQEGKFVELGLSNYAawevaeICTLCKSNGW 162
Cdd:cd19139 68 -LSKDKLLPSLEESLEKLRTDYVDLTLIHwpSPNDEVPVEEYIGALAEAKEQGLTRHIGVSNFT------IALLDEAIAV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 163 IlptvyqGMYSATTRQVetELFP----------CLRHfGLRFYAYNPLAGGlltgkykyedKDGKQPvgrffgtqwaeiy 232
Cdd:cd19139 141 V------GAGAIATNQI--ELSPylqnrklvahCKQH-GIHVTSYMTLAYG----------KVLDDP------------- 188
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1139695540 233 rnhfwkehhfegialVEKALQAAYGASAPSMtsaALRWMYHhsqlqgaHGDAVILGMSSLEQLEQNLAA 301
Cdd:cd19139 189 ---------------VLAAIAERHGATPAQI---ALAWAMA-------RGYAVIPSSTKREHLRSNLLA 232
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
24-201 |
9.54e-10 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 58.40 E-value: 9.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 24 DAPTSAAVTRAfLERGHTEIDTAFLYSDgQSETilgGLGLR-MGSSDCRVKIATKANPWIGNslkpdsVRSQLETSLKRL 102
Cdd:cd19120 24 QRDLVDSVKLA-LKAGFRHIDTAEMYGN-EKEV---GEALKeSGVPREDLFITTKVSPGIKD------PREALRKSLAKL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 103 QCPRVDLFYLHAP----DHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQGMYSATTRQ 178
Cdd:cd19120 93 GVDYVDLYLIHSPffakEGGPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLEELLDTAK----IKPAVNQIEFHPYLYP 168
|
170 180
....*....|....*....|...
gi 1139695540 179 VETELFPCLRHFGLRFYAYNPLA 201
Cdd:cd19120 169 QQPALLEYCREHGIVVSAYSPLS 191
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
30-200 |
1.16e-09 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 58.58 E-value: 1.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 30 AVTRAFLERGHTEIDTAFLYsdgQSETILGGLgLRMGSSDCRVK-----IATKANPwigNSLKPDSVRSQLETSLKRLQC 104
Cdd:cd19154 29 TAVRTALKAGYRLIDTAFLY---QNEEAIGEA-LAELLEEGVVKredlfITTKLWT---HEHAPEDVEEALRESLKKLQL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 105 PRVDLFYLHAP---------------DHSAP----VEETLRACHQLHQEGKFVELGLSNyaaWEVAEIcTLCKSNGWILP 165
Cdd:cd19154 102 EYVDLYLIHAPaafkddegesgtmenGMSIHdavdVEDVWRGMEKVYDEGLTKAIGVSN---FNNDQI-QRILDNARVKP 177
|
170 180 190
....*....|....*....|....*....|....*
gi 1139695540 166 TVYQGMYSATTRQVETELFpCLRHfGLRFYAYNPL 200
Cdd:cd19154 178 HNNQVECHLYFPQKELVEF-CKKH-NISVTSYATL 210
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
10-308 |
1.32e-09 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 58.14 E-value: 1.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 10 PATVLGAMEMGR--RMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSETILG-GLGLRMGSSdcrVKIATKANPWI--GN 84
Cdd:cd19162 1 PRLGLGAASLGNlaRAGEDEAAATLDAAWDAGIRYFDTAPLYGLGLSERRLGaALARHPRAE---YVVSTKVGRLLepGA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 85 SLKP-----------DSVRSQLETSLKRLQCPRVDLFYLHAPDH--SAPVEETLRACHQLHQEGKFVELGL---SNYAAW 148
Cdd:cd19162 78 AGRPagadrrfdfsaDGIRRSIEASLERLGLDRLDLVFLHDPDRhlLQALTDAFPALEELRAEGVVGAIGVgvtDWAALL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 149 EVAEICTLcksnGWILPTvyqGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRffgTQW 228
Cdd:cd19162 158 RAARRADV----DVVMVA---GRYTLLDRRAATELLPLCAAKGVAVVAAGVFNSGILATDDPAGDRYDYRPATP---EVL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 229 AeiyrnhfwkehHFEGIAlvekALQAAYGASAPsmtSAALRWMYHHSQLQgahgdAVILGMSSLEQLEQNLAAAEEGPLE 308
Cdd:cd19162 228 A-----------RARRLA----AVCRRYGVPLP---AAALQFPLRHPAVA-----SVVVGAASPAELRDNLALLRTPIPA 284
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
24-219 |
1.73e-09 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 57.38 E-value: 1.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 24 DAPTSAAVTRAfLERGHTEIDTAFLYsdGQSETIlgGLGLRmGSSDCR--VKIATKAnpWigNSLKP-DSVRSQLETSLK 100
Cdd:cd19131 22 NDEAASAVREA-LEVGYRSIDTAAIY--GNEEGV--GKAIR-ASGVPReeLFITTKL--W--NSDQGyDSTLRAFDESLR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 101 RLQCPRVDLFYLHAPdhsAPVE----ETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQGMYSATT 176
Cdd:cd19131 92 KLGLDYVDLYLIHWP---VPAQdkyvETWKALIELKKEGRVKSIGVSNFTIEHLQRLIDETG----VVPVVNQIELHPRF 164
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1139695540 177 RQVETELFpCLRHfGLRFYAYNPLA-GGLLTGKY--KYEDKDGKQP 219
Cdd:cd19131 165 QQRELRAF-HAKH-GIQTESWSPLGqGGLLSDPVigEIAEKHGKTP 208
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
24-203 |
6.35e-09 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 55.66 E-value: 6.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 24 DAPTSAAVTRAfLERGHTEIDTAFLYsdgQSETILGGlGLRmgssDCRVK-----IATKAnpWIGNSlKPDSVRSQLETS 98
Cdd:cd19133 22 PEECERAVLEA-IKAGYRLIDTAAAY---GNEEAVGR-AIK----KSGIPreelfITTKL--WIQDA-GYEKAKKAFERS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 99 LKRLQCPRVDLFYLHAPDHSapVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVyqgmysattRQ 178
Cdd:cd19133 90 LKRLGLDYLDLYLIHQPFGD--VYGAWRAMEELYKEGKIRAIGVSNFYPDRLVDLILHNE----VKPAV---------NQ 154
|
170 180 190
....*....|....*....|....*....|..
gi 1139695540 179 VET-------ELFPCLRHFGLRFYAYNPLAGG 203
Cdd:cd19133 155 IEThpfnqqiEAVEFLKKYGVQIEAWGPFAEG 186
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
30-200 |
2.59e-08 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 54.27 E-value: 2.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 30 AVTRAfLERGHTEIDTAFLYsdGQSETIlgGLGLRMGSSDCRVK-----IATKAnpWIgNSLKPDSVRSQLETSLKRLQC 104
Cdd:cd19125 29 AVKTA-IKEGYRHIDCAAIY--GNEKEI--GKALKKLFEDGVVKredlfITSKL--WC-TDHAPEDVPPALEKTLKDLQL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 105 PRVDLFYLHAPDH--------------SAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQG 170
Cdd:cd19125 101 DYLDLYLIHWPVRlkkgahmpepeevlPPDIPSTWKAMEKLVDSGKVRAIGVSNFSVKKLEDLLAVAR----VPPAVNQV 176
|
170 180 190
....*....|....*....|....*....|
gi 1139695540 171 MYSATTRQveTELFPCLRHFGLRFYAYNPL 200
Cdd:cd19125 177 ECHPGWQQ--DKLHEFCKSKGIHLSAYSPL 204
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
24-169 |
3.05e-08 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 54.21 E-value: 3.05e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 24 DAPTSAAVTRAfLERGHTEIDTAFLYsdgQSETILGgLGLRMGSSDCRVK-----IATKAnpWiGNSLKPDSVRSQLETS 98
Cdd:cd19116 24 DEGVRQAVKHA-IEAGYRHIDTAYLY---GNEAEVG-EAIREKIAEGVVKredlfITTKL--W-NSYHEREQVEPALRES 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 99 LKRLQCPRVDLFYLHAP------------DHSAPVE----ETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngw 162
Cdd:cd19116 96 LKRLGLDYVDLYLIHWPvafkenndsesnGDGSLSDidylETWRGMEDLVKLGLTRSIGVSNFNSEQINRLLSNCN---- 171
|
....*..
gi 1139695540 163 ILPTVYQ 169
Cdd:cd19116 172 IKPAVNQ 178
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
89-205 |
3.99e-08 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 53.48 E-value: 3.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 89 DSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPV-------EETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsng 161
Cdd:cd19135 83 ESTKQAFEASLKRLGVDYLDLYLLHWPDCPSSGknvketrAETWRALEELYDEGLCRAIGVSNFLIEHLEQLLEDCS--- 159
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1139695540 162 wILPTVYQGMYSATTRQVetELFPCLRHFGLRFYAYNPLAGGLL 205
Cdd:cd19135 160 -VVPHVNQVEFHPFQNPV--ELIEYCRDNNIVFEGYCPLAKGKA 200
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
29-200 |
1.47e-07 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 52.14 E-value: 1.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 29 AAVTRAfLERGHTEIDTAFLYsdgQSETILGGLgLRMGSSDCRVK-----IATKAnPWIGNslKPDSVRSQLETSLKRLQ 103
Cdd:cd19155 29 TAVDTA-LEAGYRHIDTAYVY---RNEAAIGNV-LKKWIDSGKVKreelfIVTKL-PPGGN--RREKVEKFLLKSLEKLQ 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 104 CPRVDLFYLHAP---------------------DHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngw 162
Cdd:cd19155 101 LDYVDLYLIHFPvgslskeddsgkldptgehkqDYTTDLLDIWKAMEAQVDQGLTRSIGLSNFNREQMARILKNAR---- 176
|
170 180 190
....*....|....*....|....*....|....*...
gi 1139695540 163 ILPTVYQGMYSATTRQVETELFpCLRHfGLRFYAYNPL 200
Cdd:cd19155 177 IKPANLQVELHVYLQQKDLVDF-CSTH-SITVTAYAPL 212
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
30-202 |
1.59e-07 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 51.75 E-value: 1.59e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 30 AVTRAFlERGHTEIDTAFLYsdGQSETIlgGLGLRMGSSDCRVK-----IATKANPwigNSLKPDSVRSQLETSLKRLQC 104
Cdd:cd19128 19 AVKNAI-KAGYRHIDCAYYY--GNEAFI--GIAFSEIFKDGGVKredlfITSKLWP---TMHQPENVKEQLLITLQDLQL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 105 PRVDLFYLHAP-------------------DHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILP 165
Cdd:cd19128 91 EYLDLFLIHWPlafdmdtdgdprddnqiqsLSKKPLEDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDLLNYCK----IKP 166
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1139695540 166 tvyqgmysaTTRQVETEL-FP-------CLRHfGLRFYAYNPLAG 202
Cdd:cd19128 167 ---------FMNQIECHPyFQndklikfCIEN-NIHVTAYRPLGG 201
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
31-205 |
1.70e-07 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 51.67 E-value: 1.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 31 VTRAFLERGHTEIDTAFLYsdgQSETILGGLGLRMGSSDCRVKIATKAnpWiGNSLKPDSVRSQLETSLKRLQCPRVDLF 110
Cdd:cd19126 28 AVQTALENGYRSIDTAAIY---KNEEGVGEAIRESGVPREELFVTTKL--W-NDDQRARRTEDAFQESLDRLGLDYVDLY 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 111 YLH--APDHsapVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQGMYSAttRQVETELFPCLR 188
Cdd:cd19126 102 LIHwpGKDK---FIDTWKALEKLYASGKVKAIGVSNFQEHHLEELLAHAD----VVPAVNQVEFHP--YLTQKELRGYCK 172
|
170
....*....|....*..
gi 1139695540 189 HFGLRFYAYNPLAGGLL 205
Cdd:cd19126 173 SKGIVVEAWSPLGQGGL 189
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
10-145 |
2.13e-07 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 51.51 E-value: 2.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 10 PATVLGAMEMGRR-----MDAPTSAAVTRAfLERGHTEIDTAFLYsdGQSETILGGL--GLRMGSSDCRVKIATKANPwI 82
Cdd:cd19164 14 PPLIFGAATFSYQyttdpESIPPVDIVRRA-LELGIRAFDTSPYY--GPSEIILGRAlkALRDEFPRDTYFIITKVGR-Y 89
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1139695540 83 GNS---LKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAP--VEETLRACHQLHQEGKFVELGLSNY 145
Cdd:cd19164 90 GPDdfdYSPEWIRASVERSLRRLHTDYLDLVYLHDVEFVADeeVLEALKELFKLKDEGKIRNVGISGY 157
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
29-303 |
4.54e-07 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 50.49 E-value: 4.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 29 AAVTRAfLERGHTEIDTAFLYsDGQSEtILGGLGLRMGSSdcrvKIaTKANPWI-----GNSLKPDSVRSQLETSLKRLQ 103
Cdd:cd19123 29 QAVKQA-LEAGYRHIDCAAIY-GNEAE-IGAALAEVFKEG----KV-KREDLWItsklwNNSHAPEDVLPALEKTLADLQ 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 104 CPRVDLFYLHAP---------DHSA---------PVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILP 165
Cdd:cd19123 101 LDYLDLYLMHWPvalkkgvgfPESGedllslspiPLEDTWRAMEELVDKGLCRHIGVSNFSVKKLEDLLATAR----IKP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 166 TVYQgmysattrqveTELFPCL---------RHFGLRFYAYNPLAGGLLTGKYKYEDKDG--KQPVgrffgtqwaeiyrn 234
Cdd:cd19123 177 AVNQ-----------VELHPYLqqpellafcRDNGIHLTAYSPLGSGDRPAAMKAEGEPVllEDPV-------------- 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1139695540 235 hfwkehhFEGIAlvekalqAAYGASAPSMtsaALRWMYHhsqlqgaHGDAVILGMSSLEQLEQNLAAAE 303
Cdd:cd19123 232 -------INKIA-------EKHGASPAQV---LIAWAIQ-------RGTVVIPKSVNPERIQQNLEAAE 276
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
19-205 |
5.02e-07 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 50.21 E-value: 5.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 19 MGRRMDAPTSAAVTRAFLERGHTEIDTAFLYSDGQSEtilgGLGLRM-GSSDCRVKIATKAnpWigNSLKP-DSVRSQLE 96
Cdd:cd19156 16 VWRVQDGAEAENAVKWAIEAGYRHIDTAAIYKNEEGV----GQGIREsGVPREEVFVTTKL--W--NSDQGyESTLAAFE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 97 TSLKRLQCPRVDLFYLHAPdHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQgmysatt 176
Cdd:cd19156 88 ESLEKLGLDYVDLYLIHWP-VKGKFKDTWKAFEKLYKEKKVRAIGVSNFHEHHLEELLKSCK----VAPMVNQ------- 155
|
170 180 190
....*....|....*....|....*....|....*...
gi 1139695540 177 rqveTELFPCLRHFGLRFY---------AYNPLAGGLL 205
Cdd:cd19156 156 ----IELHPLLTQEPLRKFckekniaveAWSPLGQGKL 189
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
29-200 |
8.55e-07 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 49.69 E-value: 8.55e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 29 AAVTRAfLERGHTEIDTAFLYS------DGQSETILGGLGLRmgssdcRVKIATKANPWiGNSLKPDSVRSQLETSLKRL 102
Cdd:cd19106 24 AAVKYA-LDAGYRHIDCAAVYGneqevgEALKEKVGPGKAVP------REDLFVTSKLW-NTKHHPEDVEPALRKTLKDL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 103 QCPRVDLFYLHAP------DH-------------SAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICtlckSNGWI 163
Cdd:cd19106 96 QLDYLDLYLIHWPyafergDNpfpknpdgtirydSTHYKETWKAMEKLVDKGLVKAIGLSNFNSRQIDDIL----SVARI 171
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1139695540 164 LPTVYqgmysattrQVE-------TELFPCLRHFGLRFYAYNPL 200
Cdd:cd19106 172 KPAVL---------QVEchpylaqNELIAHCKARGLVVTAYSPL 206
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
26-304 |
8.90e-07 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 49.84 E-value: 8.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 26 PTSAAVTRAFlERGHTEIDTAFLYSDGQSETILGGLGLRMGSSDCRVKIATKANPW--IGNSLKPDSVRSQLETSLKRLQ 103
Cdd:cd19153 34 EAVAIVAEAF-AAGINHFDTSPYYGAESSEAVLGKALAALQVPRSSYTVATKVGRYrdSEFDYSAERVRASVATSLERLH 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 104 CPRVDLFYLHA---PDHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGwilPTVYQGmYSATTRQVE 180
Cdd:cd19153 113 TTYLDVVYLHDiefVDYDTLVDEALPALRTLKDEGVIKRIGIAGYPLDTLTRATRRCSPGS---LDAVLS-YCHLTLQDA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 181 TELF--PCLRH-FGLRFYAYNPLAGGLLTGKykyedkdGKQPvgrffgtqwaeiyrnhfWKEHHFEgiaLVEKALQA-AY 256
Cdd:cd19153 189 RLESdaPGLVRgAGPHVINASPLSMGLLTSQ-------GPPP-----------------WHPASGE---LRHYAAAAdAV 241
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1139695540 257 GASAP-SMTSAALRWMYHHSQLQGahgdAVILGMSSLEQLEQNLAAAEE 304
Cdd:cd19153 242 CASVEaSLPDLALQYSLAAHAGVG----TVLLGPSSLAQLRSMLAAVDA 286
|
|
| AKR_AKR1C1-35 |
cd19108 |
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ... |
26-161 |
9.97e-07 |
|
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.
Pssm-ID: 381334 [Multi-domain] Cd Length: 303 Bit Score: 49.54 E-value: 9.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 26 PTSAAV--TRAFLERGHTEIDTAFLYsdgQSETILGgLGLRMGSSDCRVK-----IATKAnpWIgNSLKPDSVRSQLETS 98
Cdd:cd19108 25 PKSKALeaTKLAIDAGFRHIDSAYLY---QNEEEVG-QAIRSKIADGTVKredifYTSKL--WC-TFHRPELVRPALEKS 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 99 LKRLQCPRVDLFYLHAPDHSAPVEETLRAchqlHQEGKF----VELglsnYAAWEVAEICT---LCKSNG 161
Cdd:cd19108 98 LKKLQLDYVDLYLIHFPVALKPGEELFPK----DENGKLifdtVDL----CATWEAMEKCKdagLAKSIG 159
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
33-203 |
1.10e-06 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 49.31 E-value: 1.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 33 RAFLERGHTEIDTAFLYsdgQSETILGgLGLRMGSSDcRVKIATKANPWiGNSLKPDSVRSQLETSLKRLQCPRVDLFYL 112
Cdd:cd19157 31 KTALKNGYRSIDTAAIY---GNEEGVG-KGIKESGIP-REELFITSKVW-NADQGYDSTLKAFEASLERLGLDYLDLYLI 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 113 HAPDHSAPVeETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKsngwILPTVYQGMYSAttRQVETELFPCLRHFGL 192
Cdd:cd19157 105 HWPVKGKYK-ETWKALEKLYKDGRVRAIGVSNFQVHHLEDLLADAE----IVPMVNQVEFHP--RLTQKELRDYCKKQGI 177
|
170
....*....|.
gi 1139695540 193 RFYAYNPLAGG 203
Cdd:cd19157 178 QLEAWSPLMQG 188
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
24-204 |
1.12e-06 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 49.38 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 24 DAPTSAAVTRAFLERGHTEIDTAFLYSDGQSEtilgGLGLRMGSSDCRVK-----IATKAnpWIGNSlKPDSVRSQLETS 98
Cdd:cd19129 17 DPSATRNAVKAALEAGFRHFDCAERYRNEAEV----GEAMQEVFKAGKIRredlfVTTKL--WNTNH-RPERVKPAFEAS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 99 LKRLQCPRVDLFYLHAP--------------------DHSAPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCK 158
Cdd:cd19129 90 LKRLQLDYLDLYLIHTPfafqpgdeqdprdangnviyDDGVTLLDTWRAMERLVDEGRCKAIGLSDVSLEKLREIFEAAR 169
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1139695540 159 sngwILPTVYQgmYSATTRQVETELFPCLRHFGLRFYAYNPLAGGL 204
Cdd:cd19129 170 ----IKPAVVQ--VESHPYLPEWELLDFCKNHGIVLQAFAPLGHGM 209
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
7-205 |
1.80e-06 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 48.70 E-value: 1.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 7 RARPATVLGAMEMGrrmDAPTSAAVTRAfLERGHTEIDTAFLYSDgqsETILGGLGLRMGSSDCRVKIATK-ANPWIGNs 85
Cdd:cd19134 9 NTMPVIGLGVGELS---DDEAERSVSAA-LEAGYRLIDTAAAYGN---EAAVGRAIAASGIPRGELFVTTKlATPDQGF- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 86 lkpDSVRSQLETSLKRLQCPRVDLFYLH--APDHSAPVeETLRACHQLHQEGKFVELGLSNYAAWEVAEICtlckSNGWI 163
Cdd:cd19134 81 ---TASQAACRASLERLGLDYVDLYLIHwpAGREGKYV-DSWGGLMKLREEGLARSIGVSNFTAEHLENLI----DLTFF 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1139695540 164 LPTVYQgmysattrqveTELFPCLRHFGLRFY---------AYNPLAGGLL 205
Cdd:cd19134 153 TPAVNQ-----------IELHPLLNQAELRKVnaqhgivtqAYSPLGVGRL 192
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
29-313 |
6.30e-06 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 47.08 E-value: 6.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 29 AAVTRAFlERGHTEIDTAFLYSDGQSETILGGlGLR-MGSSDCRVKIATKANPWI-GNSLKPDSVRSQLETSLKRLQCPR 106
Cdd:PLN02587 35 ASVREAF-RLGINFFDTSPYYGGTLSEKVLGK-ALKaLGIPREKYVVSTKCGRYGeGFDFSAERVTKSVDESLARLQLDY 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 107 VDLFYLHAPDHSA---PVEETLRACHQLHQEGKFVELGLSNYAAwevaEICTlcksngWILPTVYQGM---------YSA 174
Cdd:PLN02587 113 VDILHCHDIEFGSldqIVNETIPALQKLKESGKVRFIGITGLPL----AIFT------YVLDRVPPGTvdvilsychYSL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 175 TTRQVEtELFPCLRHFGLRFYAYNPLAGGLLTGKykyedkdgkqpvgrffGT-QWaeiyrnhfwkehHFEGIALVEKALQ 253
Cdd:PLN02587 183 NDSSLE-DLLPYLKSKGVGVISASPLAMGLLTEN----------------GPpEW------------HPAPPELKSACAA 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1139695540 254 AAY--GASAPSMTSAALRWMYHHSQLQgahgdAVILGMSSLEQLEQNLAAAEEgpLEPAVVD 313
Cdd:PLN02587 234 AAThcKEKGKNISKLALQYSLSNKDIS-----TTLVGMNSVQQVEENVAAATE--LETSGID 288
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
36-145 |
7.09e-06 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 46.94 E-value: 7.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 36 LERGHTEIDTAFLYSDgqsETILGGLGLRMGSSDCRVKIATKAnpWIGNsLKPDSVRSQLETSLKRLQCPRVDLFYLH-- 113
Cdd:PRK11172 26 LELGYRAIDTAQIYDN---EAAVGQAIAESGVPRDELFITTKI--WIDN-LAKDKLIPSLKESLQKLRTDYVDLTLIHwp 99
|
90 100 110
....*....|....*....|....*....|..
gi 1139695540 114 APDHSAPVEETLRACHQLHQEGKFVELGLSNY 145
Cdd:PRK11172 100 SPNDEVSVEEFMQALLEAKKQGLTREIGISNF 131
|
|
| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
24-145 |
8.72e-06 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 46.44 E-value: 8.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 24 DAPTSAAVTRAfLERGHTEIDTAFLYSDGQsetilgGLGLRMGSSDC---RVKIATKAnpWIGNSlKPDSVRSQLETSLK 100
Cdd:cd19130 22 PADTQRAVATA-LEVGYRHIDTAAIYGNEE------GVGAAIAASGIprdELFVTTKL--WNDRH-DGDEPAAAFAESLA 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1139695540 101 RLQCPRVDLFYLHAPDHSAPVE-ETLRACHQLHQEGKFVELGLSNY 145
Cdd:cd19130 92 KLGLDQVDLYLVHWPTPAAGNYvHTWEAMIELRAAGRTRSIGVSNF 137
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
13-161 |
6.14e-05 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 43.80 E-value: 6.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 13 VLGameMGRRMDAPTSAAVTRAFL---ERGHTEIDTAFLYsdgQSETILG-------GLGLRMGSSDcrVKIATKanPWI 82
Cdd:cd19124 7 VIG---MGTASDPPSPEDIKAAVLeaiEVGYRHFDTAAAY---GTEEALGealaealRLGLVKSRDE--LFVTSK--LWC 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 83 GNsLKPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETLRAchqlhQEGKFVELGLSnyAAWEVAEICT---LCKS 159
Cdd:cd19124 77 SD-AHPDLVLPALKKSLRNLQLEYVDLYLIHWPVSLKPGKFSFPI-----EEEDFLPFDIK--GVWEAMEECQrlgLTKA 148
|
..
gi 1139695540 160 NG 161
Cdd:cd19124 149 IG 150
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
27-145 |
1.78e-04 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 42.37 E-value: 1.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 27 TSAAVTRAfLERGHTEIDTAFLYSDGQsetilgGLGLRMGSSDC---RVKIATKAnpWIGNSLKPdsvRSQLETSLKRLQ 103
Cdd:PRK11565 30 VITAIHKA-LEVGYRSIDTAAIYKNEE------GVGKALKEASVareELFITTKL--WNDDHKRP---REALEESLKKLQ 97
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1139695540 104 CPRVDLFYLHAP----DHSApveETLRACHQLHQEGKFVELGLSNY 145
Cdd:PRK11565 98 LDYVDLYLMHWPvpaiDHYV---EAWKGMIELQKEGLIKSIGVCNF 140
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
29-145 |
2.48e-03 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 38.79 E-value: 2.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 29 AAVTRAfLERGHTEIDTAFLYsdgQSETILGGLGLRMGSSDCRVKIATKANpwiGNSLKPDSVRSQLETSLKRLQCPRVD 108
Cdd:cd19132 24 EAVVAA-LQAGYRLLDTAFNY---ENEGAVGEAVRRSGVPREELFVTTKLP---GRHHGYEEALRTIEESLYRLGLDYVD 96
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1139695540 109 LFYLHAPdhsAPVE----ETLRACHQLHQEGKFVELGLSNY 145
Cdd:cd19132 97 LYLIHWP---NPSRdlyvEAWQALIEAREEGLVRSIGVSNF 134
|
|
| AKR_AKR3E1 |
cd19122 |
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ... |
27-169 |
2.74e-03 |
|
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.
Pssm-ID: 381348 [Multi-domain] Cd Length: 291 Bit Score: 39.14 E-value: 2.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 27 TSAAVTRAfLERGHTEIDTAFLYsdgQSETILGGL---GLRMGSSDCRVKIATKANPWigNSL-KPDSVRSQLETSLKRL 102
Cdd:cd19122 26 TYAAVTKA-LDVGYRHLDCAWFY---LNEDEVGDAvrdFLKENPSVKREDLFICTKVW--NHLhEPEDVKWSIDNSLKNL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 103 QCPRVDLFYLHAP------DHSAPV-----------------EETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKs 159
Cdd:cd19122 100 KLDYIDLFLVHWPiaaeknDQRSPKlgpdgkyvilkdltenpEPTWRAMEEIYESGKAKAIGVSNWTIPGLKKLLSFAK- 178
|
170
....*....|
gi 1139695540 160 ngwILPTVYQ 169
Cdd:cd19122 179 ---VKPHVNQ 185
|
|
| AKR_AKR1D1-3 |
cd19109 |
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ... |
10-161 |
3.19e-03 |
|
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.
Pssm-ID: 381335 [Multi-domain] Cd Length: 308 Bit Score: 38.63 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1139695540 10 PATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFLYsdgQSETILGGlGLRMGSSDCRVK---IATKANPWIGNSl 86
Cdd:cd19109 5 PIIGLGTYSEPKTTPKGACAEAVKVAIDTGYRHIDGAYIY---QNEHEVGQ-AIREKIAEGKVKredIFYCGKLWNTCH- 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1139695540 87 KPDSVRSQLETSLKRLQCPRVDLFYLHAPDHSAPVEETlracHQLHQEGKFVELGLSNYAAWEVAEICT---LCKSNG 161
Cdd:cd19109 80 PPELVRPTLERTLKVLQLDYVDLYIIEMPMAFKPGDEI----YPRDENGKWLYHKTNLCATWEALEACKdagLVKSIG 153
|
|
| |
