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Conserved domains on  [gi|1104469902|ref|NP_001334261|]
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phosphatidylserine decarboxylase proenzyme, mitochondrial isoform 2 [Mus musculus]

Protein Classification

phosphatidylserine decarboxylase( domain architecture ID 999)

phosphatidylserine decarboxylase catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)

EC:  4.1.1.65
Gene Ontology:  GO:0004609|GO:0006646
PubMed:  27650064|9370338
SCOP:  4007787

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PS_Dcarbxylase super family cl03656
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 70-373 2.00e-86

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


The actual alignment was detected with superfamily member PLN02938:

Pssm-ID: 470849  Cd Length: 428  Bit Score: 268.23  E-value: 2.00e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902  70 PMSRVSLYKSVPTRLLSRACGRLNQVELPYWLRRPVYSLYIWTFGVNMTEAAVEdLHHYRNLSEFFRRKLKPQARPV-CG 148
Cdd:PLN02938   84 PDTKASFLRLLPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LEEYASLREFFVRSLKEGARPIdPD 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 149 LHCVTSPSDGKILTFGQVKNS--EVEQVKGVTYSLESFLG--------PRANTEDLPFPPASSSDS-----------FRN 207
Cdd:PLN02938  163 PNCLVSPVDGIVLRFGELKGPgtMIEQVKGFSYSVSALLGansllpmtAEGKEEKEEETLKDKSSKswlrvslaspkLRD 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 208 QLVTREGNELYHCVIYLAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAV 287
Cdd:PLN02938  243 PVSASPMKGLFYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNLYVENERVVLEGEWQEGFMAMAAV 322

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 288 GATNVGSIRIHFDRDLHTNSPRysKGSYND---LSFVTHANKEGIPMRKGEPLGEFNLGSTIVLIFEAP----------- 353
Cdd:PLN02938  323 GATNIGSIELFIEPELRTNRPK--KKIFNSeppEERVYEPEGCGLCLKKGDEVAVFNLGSTVVLVFEAPveveplfkvld 400

                         330       340
                  ....*....|....*....|...
gi 1104469902 354 ---KDFNFRLKAGQKIRFGEALG 373
Cdd:PLN02938  401 qssSDFRFCVRKGDRIRVGQALG 423
 
Name Accession Description Interval E-value
PLN02938 PLN02938
phosphatidylserine decarboxylase
 70-373 2.00e-86

phosphatidylserine decarboxylase


Pssm-ID: 178526  Cd Length: 428  Bit Score: 268.23  E-value: 2.00e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902  70 PMSRVSLYKSVPTRLLSRACGRLNQVELPYWLRRPVYSLYIWTFGVNMTEAAVEdLHHYRNLSEFFRRKLKPQARPV-CG 148
Cdd:PLN02938   84 PDTKASFLRLLPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LEEYASLREFFVRSLKEGARPIdPD 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 149 LHCVTSPSDGKILTFGQVKNS--EVEQVKGVTYSLESFLG--------PRANTEDLPFPPASSSDS-----------FRN 207
Cdd:PLN02938  163 PNCLVSPVDGIVLRFGELKGPgtMIEQVKGFSYSVSALLGansllpmtAEGKEEKEEETLKDKSSKswlrvslaspkLRD 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 208 QLVTREGNELYHCVIYLAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAV 287
Cdd:PLN02938  243 PVSASPMKGLFYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNLYVENERVVLEGEWQEGFMAMAAV 322

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 288 GATNVGSIRIHFDRDLHTNSPRysKGSYND---LSFVTHANKEGIPMRKGEPLGEFNLGSTIVLIFEAP----------- 353
Cdd:PLN02938  323 GATNIGSIELFIEPELRTNRPK--KKIFNSeppEERVYEPEGCGLCLKKGDEVAVFNLGSTVVLVFEAPveveplfkvld 400

                         330       340
                  ....*....|....*....|...
gi 1104469902 354 ---KDFNFRLKAGQKIRFGEALG 373
Cdd:PLN02938  401 qssSDFRFCVRKGDRIRVGQALG 423
PS_Dcarbxylase pfam02666
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 131-373 5.44e-75

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


Pssm-ID: 396989 [Multi-domain]  Cd Length: 198  Bit Score: 230.63  E-value: 5.44e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 131 LSEFFRRKLKPQARPVC-GLHCVTSPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGPRAntedlpfppasssdsfrnql 209
Cdd:pfam02666   1 LNAFFTRFLRDPARPIPaGPGAVVSPADGKISEIGEIEDDSVIQVKGVTYSLRELLGDDK-------------------- 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 210 vTREGNELYHCVIYLAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGA 289
Cdd:pfam02666  61 -LDKFKGGTFIVIYLSPFDYHRNHAPVDGTVKEVRYIPGKLLPVNPAALKEIPNLFALNERVVLVIETTDGKVAVVQVGA 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 290 TNVGSIRIHFdrdlhtnspryskgsyndlsfvthanKEGIPMRKGEPLGEFNLGSTIVLIFEAPKDFNFRLKAGQKIRFG 369
Cdd:pfam02666 140 LNVGSIVLTV--------------------------KPGDEVKKGEELGYFKFGSTVVLLFPKGKFFEDLVEPGQKVKAG 193


                  ....
gi 1104469902 370 EALG 373
Cdd:pfam02666 194 ETIG 197
PS_decarb TIGR00163
phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as ...
 117-373 2.02e-73

phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as a single chain precursor. Generation of the pyruvoyl active site from a Ser is coupled to cleavage of a Gly-Ser bond between the larger (beta) and smaller (alpha chains). It is an integral membrane protein. A closely related family, possibly also active as phosphatidylserine decarboxylase, falls under model TIGR00164. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 272936 [Multi-domain]  Cd Length: 238  Bit Score: 228.18  E-value: 2.02e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 117 MTEAAVEDLHHYRNLSEFFRRKLKPQARPVC-GLHCVTSPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGprantEDLP 195
Cdd:TIGR00163   1 LDEAEKPDLADYRSLNEFFIRPLKLERRPVDkEPNALVSPADGVISEVGIINPNQILQVKGMDYSLEELLG-----EKNP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 196 FppassSDSFRNQLvtregnelYHCVIYLAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTG 275
Cdd:TIGR00163  76 L-----SPYFRNGG--------FFVVTYLSPRDYHRFHSPCDCRLRKMRYFPGDLFSVNPLGLQNVPNLFVRNERVILVF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 276 DWKHGFFSLTAVGATNVGSIRIHFDRDLHTNSPR--YSKGSYNDLSfvthankeGIPMRKGEPLGEFNLGSTIVLIFEA- 352
Cdd:TIGR00163 143 DTEFGNMLMIPVGATNVGSIRTNFDGNIQTNPRHefTQTWTYNALG--------PVKLLKGEEMGYFELGSTVILLFEAd 214

                         250       260
                  ....*....|....*....|.
gi 1104469902 353 PKDFNFRLKAGQKIRFGEALG 373
Cdd:TIGR00163 215 AFQLSAHLAVGQEVKIGELLA 235
Psd COG0688
Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine ...
 81-375 1.64e-57

Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine decarboxylase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440452 [Multi-domain]  Cd Length: 243  Bit Score: 187.37  E-value: 1.64e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902  81 PTRLLSRACGRLNQVELPYWlrRPVYSLYIWTFGVNMTEAAVEdlhHYRNLSEFFRRKLKPQARPVC-GLHCVTSPSDGK 159
Cdd:COG0688     1 PKHLLSRLMGPIAREGWPFI--ALLIRTFIKRYGIDLSEALPS---SYTSFNDFFFRDLKPGARPIPdDPDAVVSPADGK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 160 ILTFGQVKNSEVEQVKGVTYSLESFLGPRANTEDlpfppasssdsFRN-QLVTregnelyhcvIYLAPGDYHCFHSPTDW 238
Cdd:COG0688    76 VSQIGEIEEDRLLQAKGHPYSLEELLGDSELAEK-----------FEGgTFVS----------IFLSPFDYHRNHMPVDG 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 239 TISHRRHFPGSLMSVNPGMARwiKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIHFdrdlhtnspryskgsyndl 318
Cdd:COG0688   135 TVVEVKYIPGKFLSVNPLALR--PKLFARNERVVIVIETEFGPVAVVQVGALIVRRIVTYV------------------- 193

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1104469902 319 sfvthanKEGIPMRKGEPLGEFNLGSTIVLIFEaPKDFNFRLKAGQKIRFGEALGSL 375
Cdd:COG0688   194 -------KEGDTLKKGEEMGLFKFGSTVDLLLP-KGAVEILVKPGQKVRAGETIGRL 242
 
Name Accession Description Interval E-value
PLN02938 PLN02938
phosphatidylserine decarboxylase
 70-373 2.00e-86

phosphatidylserine decarboxylase


Pssm-ID: 178526  Cd Length: 428  Bit Score: 268.23  E-value: 2.00e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902  70 PMSRVSLYKSVPTRLLSRACGRLNQVELPYWLRRPVYSLYIWTFGVNMTEAAVEdLHHYRNLSEFFRRKLKPQARPV-CG 148
Cdd:PLN02938   84 PDTKASFLRLLPLRSISRLWGSLTSVELPVWMRPYVYKAWARAFHSNLEEAALP-LEEYASLREFFVRSLKEGARPIdPD 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 149 LHCVTSPSDGKILTFGQVKNS--EVEQVKGVTYSLESFLG--------PRANTEDLPFPPASSSDS-----------FRN 207
Cdd:PLN02938  163 PNCLVSPVDGIVLRFGELKGPgtMIEQVKGFSYSVSALLGansllpmtAEGKEEKEEETLKDKSSKswlrvslaspkLRD 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 208 QLVTREGNELYHCVIYLAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAV 287
Cdd:PLN02938  243 PVSASPMKGLFYCVIYLGPGDYHRIHSPSDWNIEVRRHFSGRLFPVNERATRTIRNLYVENERVVLEGEWQEGFMAMAAV 322

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 288 GATNVGSIRIHFDRDLHTNSPRysKGSYND---LSFVTHANKEGIPMRKGEPLGEFNLGSTIVLIFEAP----------- 353
Cdd:PLN02938  323 GATNIGSIELFIEPELRTNRPK--KKIFNSeppEERVYEPEGCGLCLKKGDEVAVFNLGSTVVLVFEAPveveplfkvld 400

                         330       340
                  ....*....|....*....|...
gi 1104469902 354 ---KDFNFRLKAGQKIRFGEALG 373
Cdd:PLN02938  401 qssSDFRFCVRKGDRIRVGQALG 423
PS_Dcarbxylase pfam02666
Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4. ...
 131-373 5.44e-75

Phosphatidylserine decarboxylase; This is a family of phosphatidylserine decarboxylases, EC:4.1.1.65. These enzymes catalyze the reaction: Phosphatidyl-L-serine <=> phosphatidylethanolamine + CO2. Phosphatidylserine decarboxylase plays a central role in the biosynthesis of aminophospholipids by converting phosphatidylserine to phosphatidylethanolamine.


Pssm-ID: 396989 [Multi-domain]  Cd Length: 198  Bit Score: 230.63  E-value: 5.44e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 131 LSEFFRRKLKPQARPVC-GLHCVTSPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGPRAntedlpfppasssdsfrnql 209
Cdd:pfam02666   1 LNAFFTRFLRDPARPIPaGPGAVVSPADGKISEIGEIEDDSVIQVKGVTYSLRELLGDDK-------------------- 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 210 vTREGNELYHCVIYLAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGA 289
Cdd:pfam02666  61 -LDKFKGGTFIVIYLSPFDYHRNHAPVDGTVKEVRYIPGKLLPVNPAALKEIPNLFALNERVVLVIETTDGKVAVVQVGA 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 290 TNVGSIRIHFdrdlhtnspryskgsyndlsfvthanKEGIPMRKGEPLGEFNLGSTIVLIFEAPKDFNFRLKAGQKIRFG 369
Cdd:pfam02666 140 LNVGSIVLTV--------------------------KPGDEVKKGEELGYFKFGSTVVLLFPKGKFFEDLVEPGQKVKAG 193


                  ....
gi 1104469902 370 EALG 373
Cdd:pfam02666 194 ETIG 197
PS_decarb TIGR00163
phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as ...
 117-373 2.02e-73

phosphatidylserine decarboxylase precursor; Phosphatidylserine decarboxylase is synthesized as a single chain precursor. Generation of the pyruvoyl active site from a Ser is coupled to cleavage of a Gly-Ser bond between the larger (beta) and smaller (alpha chains). It is an integral membrane protein. A closely related family, possibly also active as phosphatidylserine decarboxylase, falls under model TIGR00164. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 272936 [Multi-domain]  Cd Length: 238  Bit Score: 228.18  E-value: 2.02e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 117 MTEAAVEDLHHYRNLSEFFRRKLKPQARPVC-GLHCVTSPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGprantEDLP 195
Cdd:TIGR00163   1 LDEAEKPDLADYRSLNEFFIRPLKLERRPVDkEPNALVSPADGVISEVGIINPNQILQVKGMDYSLEELLG-----EKNP 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 196 FppassSDSFRNQLvtregnelYHCVIYLAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTG 275
Cdd:TIGR00163  76 L-----SPYFRNGG--------FFVVTYLSPRDYHRFHSPCDCRLRKMRYFPGDLFSVNPLGLQNVPNLFVRNERVILVF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 276 DWKHGFFSLTAVGATNVGSIRIHFDRDLHTNSPR--YSKGSYNDLSfvthankeGIPMRKGEPLGEFNLGSTIVLIFEA- 352
Cdd:TIGR00163 143 DTEFGNMLMIPVGATNVGSIRTNFDGNIQTNPRHefTQTWTYNALG--------PVKLLKGEEMGYFELGSTVILLFEAd 214

                         250       260
                  ....*....|....*....|.
gi 1104469902 353 PKDFNFRLKAGQKIRFGEALG 373
Cdd:TIGR00163 215 AFQLSAHLAVGQEVKIGELLA 235
PRK03934 PRK03934
phosphatidylserine decarboxylase; Provisional
 81-375 2.45e-62

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 235177 [Multi-domain]  Cd Length: 265  Bit Score: 200.56  E-value: 2.45e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902  81 PTRLLSRACGRLNQVELPYWLRRPVYSLYIWTFGVNMTEaaVEDLHHYRNLSEFFRRKLKPQaRPV-CGLHCVTSPSDGK 159
Cdd:PRK03934    3 LSNALSRIFGKFAGYKFPKFIQKFINASYVKIFKIDMSE--FKPPENYKSLNALFTRSLKKP-REFdEDPNIFISPCDSL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 160 ILTFGQVKNSEVEQVKGVTYSLESFLGPRANTEDLPFppasssdSFRNqlvtregnelyhcvIYLAPGDYHCFHSPTDWT 239
Cdd:PRK03934   80 ITECGSLEEDKALQIKGMEYSIEELLGESNSELVNGF-------DYIN--------------FYLSPKDYHRYHAPCDLE 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 240 ISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHG-FFSLTAVGATNVGSIRIHFDRDLHTNSpryskgsynDL 318
Cdd:PRK03934  139 ILEARYIPGKLYPVNLPSLEKNKNLFVKNERVVLKCKDKKGkRLYFVFVGALNVGKMRFNFDERIQTNA---------KA 209

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1104469902 319 SFVTHANKEGIPMRKGEPLGEFNLGSTIVLIFEaPKDFNFRLKAGQKIRFGEALGSL 375
Cdd:PRK03934  210 RFIQTYEYENLKLKKGEELGNFEMGSTIVLFSQ-KGSLEFNLKAGKSVKFGESIGEI 265
PTZ00403 PTZ00403
phosphatidylserine decarboxylase; Provisional
 82-373 1.61e-60

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 173594  Cd Length: 353  Bit Score: 198.92  E-value: 1.61e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902  82 TRLL-----SRACGRLNQVELPYWLRRPVYSLYIWTFGVNmTEAAVEDLHHYRNLSEFFRRKLKPQARPV--CGLHCVTS 154
Cdd:PTZ00403   57 ARLLfgrtrSRITGSIFNIEIPNTYRLPIYNFLIKYMGIN-KEEIKYPIESYKSIGDFFSRYIREETRPIgdVSDYSIVS 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 155 PSDGKILTFGQVKNSEVEQVKGVTYSLESFLGprantedLPFPPASSSDSfrnqlvtregNELYHCVIYLAPGDYHCFHS 234
Cdd:PTZ00403  136 PCDSELTDYGELSSEYLENVKGVKFNVNTFLG-------SDMQKKYNDGS----------TKFFYAIFYLSPKKYHHFHA 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 235 PTDWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIHFDRDLHTNSPR----Y 310
Cdd:PTZ00403  199 PFNFKYKIRRHISGELFPVFQGMFKIINNLFNINERVILSGEWKGGNVYYAAISAYNVGNIKIINDEELVTNNLRtqlsY 278

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1104469902 311 SKGSYNDLSFVTHANKEgipmrKGEPLGEFNLGSTIVLIFEAPKDFNFRLKAGQKIRFGEALG 373
Cdd:PTZ00403  279 MGGDINTKIYDSYKSVE-----VGDEVGEFRMGSSIVVIFENKKNFSWNVKPNQTVSVGQRLG 336
psd PRK00044
phosphatidylserine decarboxylase; Reviewed
 80-373 2.84e-59

phosphatidylserine decarboxylase; Reviewed


Pssm-ID: 234591  Cd Length: 288  Bit Score: 193.50  E-value: 2.84e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902  80 VPTRLLSRACGRLNQVELPyWLRRPVYSLYIWTFGVNMTEAAVEDLHHYRNLSEFFRRKLKPQARPVC-GLHCVTSPSDG 158
Cdd:PRK00044   13 LPKHLLTRLAGWLASSRAG-WLTTAVIRLFIKKYKVDMSEAQKPDPAAYKTFNDFFTRALKDGARPIDeDPNALVSPADG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 159 KILTFGQVKNSEVEQVKGVTYSLESFLGpraNTEDLpfppassSDSFRN-QLVTregnelyhcvIYLAPGDYHCFHSPTD 237
Cdd:PRK00044   92 AISQLGPIEDGQIFQAKGHSYSLEALLG---GDAAL-------ADPFRNgSFAT----------IYLSPRDYHRVHMPCD 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 238 WTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRihfdrdlhT------NSPRY- 310
Cdd:PRK00044  152 GTLREMIYVPGDLFSVNPLTARNVPNLFARNERVVCLFDTEFGPMAQVLVGATIVGSIE--------TvwagtvTPPREg 223

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1104469902 311 --SKGSYNDlsfvthANKEGIPMRKGEPLGEFNLGSTIVLIFEAPK-DFNFRLKAGQKIRFGEALG 373
Cdd:PRK00044  224 iiKRWDYPE------AGDGAITLKKGAEMGRFKLGSTVINLFPPGKvQLAEQLQAGSVVRMGQPLA 283
Psd COG0688
Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine ...
 81-375 1.64e-57

Phosphatidylserine decarboxylase [Lipid transport and metabolism]; Phosphatidylserine decarboxylase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440452 [Multi-domain]  Cd Length: 243  Bit Score: 187.37  E-value: 1.64e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902  81 PTRLLSRACGRLNQVELPYWlrRPVYSLYIWTFGVNMTEAAVEdlhHYRNLSEFFRRKLKPQARPVC-GLHCVTSPSDGK 159
Cdd:COG0688     1 PKHLLSRLMGPIAREGWPFI--ALLIRTFIKRYGIDLSEALPS---SYTSFNDFFFRDLKPGARPIPdDPDAVVSPADGK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 160 ILTFGQVKNSEVEQVKGVTYSLESFLGPRANTEDlpfppasssdsFRN-QLVTregnelyhcvIYLAPGDYHCFHSPTDW 238
Cdd:COG0688    76 VSQIGEIEEDRLLQAKGHPYSLEELLGDSELAEK-----------FEGgTFVS----------IFLSPFDYHRNHMPVDG 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 239 TISHRRHFPGSLMSVNPGMARwiKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIHFdrdlhtnspryskgsyndl 318
Cdd:COG0688   135 TVVEVKYIPGKFLSVNPLALR--PKLFARNERVVIVIETEFGPVAVVQVGALIVRRIVTYV------------------- 193

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1104469902 319 sfvthanKEGIPMRKGEPLGEFNLGSTIVLIFEaPKDFNFRLKAGQKIRFGEALGSL 375
Cdd:COG0688   194 -------KEGDTLKKGEEMGLFKFGSTVDLLLP-KGAVEILVKPGQKVRAGETIGRL 242
PRK03140 PRK03140
phosphatidylserine decarboxylase; Provisional
 101-375 7.17e-33

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 179544 [Multi-domain]  Cd Length: 259  Bit Score: 123.56  E-value: 7.17e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 101 LRRPVYSLYIWTFGVNMTEAAvEDLHHYRNLSEFFRRKLKPQARPV-CGLHCVTSPSDGKILTFGQVKNSEVEQVKGVTY 179
Cdd:PRK03140   30 LSSILIPSYAKVYQINQDEME-KGLKEYRTLHELFTRKLKEGKRPIdTDASSIVSPVDGVFADVGPIEDDKTFDVKGKRY 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 180 SLESFLGprantedlpfppasssdsfrNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTISH-----RRHFPgslmsVN 254
Cdd:PRK03140  109 SIAEMLG--------------------NEERAQRYAGGTYMVLYLSPSHYHRIHSPISGTVTEqfvlgRKSYP-----VN 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 255 PGMARWIKELFCHNERVV--LTGDWKHgfFSLTAVGATNVGSIRIhfdrdlhtnspryskgsyndlsfvTHANKEgipMR 332
Cdd:PRK03140  164 ALGLEYGKRPLSKNYRSVteVNSDGEH--MALVKVGAMFVNSIEL------------------------THERDT---VQ 214

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1104469902 333 KGEPLGEFNLGSTIVLIFEapKD---FNFRLKAGQKIRFGEALGSL 375
Cdd:PRK03140  215 KGEEMAYFSFGSTVVLLFE--KDmiePDQELKSGQEVRLGEKIGTR 258
PRK00723 PRK00723
phosphatidylserine decarboxylase; Provisional
 113-373 1.70e-31

phosphatidylserine decarboxylase; Provisional


Pssm-ID: 179097 [Multi-domain]  Cd Length: 297  Bit Score: 120.79  E-value: 1.70e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 113 FGVNMTEAAvEDLHHYRNLSEFFRRKLKPQARPVC-GLHCVTSPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGprant 191
Cdd:PRK00723   69 FNIDMSESE-KPLSDFKSFNDFFTRKLKPEARPIDqGENILISPGDGRLLAYENIDLNSLFQVKGKTYSLKELLG----- 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 192 edlpfppasssdsfrNQLVTREgnelYH---CVIY-LAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPGMARWIKELFCH 267
Cdd:PRK00723  143 ---------------DPELAKK----YAggtCLILrLCPTDYHRFHFPDSGICEETRKIKGHYYSVNPIALKKIFELFCE 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 268 NER--VVLTGDwKHGFFSLTAVGATNVGSIrihfdrdLHTNSPryskgsyndlsfvthankeGIPMRKGEPLGEFNL-GS 344
Cdd:PRK00723  204 NKRewSIFKSE-NFGDILYVEVGATCVGSI-------IQTYKP-------------------NKKVKKGDEKGYFKFgGS 256

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1104469902 345 TIVLIFEAPK-----DF--NFRLKAGQKIRFGEALG 373
Cdd:PRK00723  257 TVILFFEKNKikidaDIleQSKLGYETKVLMGESIG 292
PRK09629 PRK09629
bifunctional thiosulfate sulfurtransferase/phosphatidylserine decarboxylase; Provisional
 80-373 2.77e-30

bifunctional thiosulfate sulfurtransferase/phosphatidylserine decarboxylase; Provisional


Pssm-ID: 104071 [Multi-domain]  Cd Length: 610  Bit Score: 122.15  E-value: 2.77e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902  80 VPTRLLSRACGRLNQVELpYWLRRPVYSLYIWTFGVNMTEAAVEDLHHYRNLSEFFRRKLKPQARPV-CGLHCVTSPSDG 158
Cdd:PRK09629  336 LPHHLLSRLAGCVAECRV-RWFKNAFTAWFARRYQVDMSQALVEDLTSYEHFNAFFTRALKADARPLdTTPGAILSPADG 414

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 159 KILTFGQVKNSEVEQVKGVTYSLESFLG--PRANTedlPFppasssdsfrnqlvtrEGNELyhCVIYLAPGDYHCFHSPT 236
Cdd:PRK09629  415 AISQLGPIDHGRIFQAKGHSFSVLELLGgdPKLSA---PF----------------MGGEF--ATVYLSPKDYHRVHMPL 473

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 237 DWTISHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIHFDRDLHTNSPRYSKGSYN 316
Cdd:PRK09629  474 AGTLREMVYVPGRIFSVNQTTAENVPELFARNERVVCLFDTERGPMAVVLVGAMIVASVETVWAGLVTPPKRELKTFSYD 553

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1104469902 317 DlsfvthANKEGIPMRKGEPLGEFNLGSTIVLIFeAPKDFNF--RLKAGQKIRFGEALG 373
Cdd:PRK09629  554 E------AARAPIHLEKGAEMGRFKLGSTAIVLF-GPNQVKWaeQLTAGSKVQMGQALA 605
PLN02964 PLN02964
phosphatidylserine decarboxylase
 115-352 8.03e-21

phosphatidylserine decarboxylase


Pssm-ID: 215520 [Multi-domain]  Cd Length: 644  Bit Score: 94.16  E-value: 8.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 115 VNMTEAAvEDLHHYRNLSEFFRRKLKPQARPV-CGLH--CVTSPSDGKILTFGQVKNSEVEQVKGVTYSLESFLGPRANT 191
Cdd:PLN02964  401 INMDEVK-YPLEHFKTFNEFFIRELKPGARPIaCMDNddVAVCAADCRLMAFQSVDDSTRFWIKGRKFSIKGLLGKKVHS 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 192 EDLPFPPasssdsfrnqlvtregnelyhCVIY-LAPGDYHCFHSPTDWTISHRRHFPGSLMSVNPgMARWIK--ELFCHN 268
Cdd:PLN02964  480 DAFLDGS---------------------LVIFrLAPQDYHRFHVPVSGVIEKFVDVPGSLYTVNP-IAVNSKycNVFTEN 537

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1104469902 269 ERVV-LTGDWKHGFFSLTAVGATNVGSIrihfdrdlhtnspryskgsyndlsfvTHANKEGIPMRKGEPLGEFNLG-STI 346
Cdd:PLN02964  538 KRAVcIISTAEFGKVAFVAIGATMVGSI--------------------------TFVKKEGDHVKKGDELGYFSFGgSTV 591


                  ....*.
gi 1104469902 347 VLIFEA 352
Cdd:PLN02964  592 ICVFEK 597
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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