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Conserved domains on  [gi|1063743433|ref|NP_001332654|]
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Zincin-like metalloproteases family protein [Arabidopsis thaliana]

Protein Classification

M3 family metallopeptidase( domain architecture ID 10157872)

M3 family metallopeptidase with varied activities, and contains the HEXXH motif that forms the active site in conjunction with a C-terminally-located Glu residue; similar to Arabidopsis thaliana cytosolic oligopeptidase A

EC:  3.4.24.-
Gene Ontology:  GO:0004222|GO:0008270|GO:0006508
MEROPS:  M3
PubMed:  7674922
SCOP:  3001975

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
M3A_DCP cd06456
Peptidase family M3, dipeptidyl carboxypeptidase (DCP); Peptidase family M3 dipeptidyl ...
154-798 0e+00

Peptidase family M3, dipeptidyl carboxypeptidase (DCP); Peptidase family M3 dipeptidyl carboxypeptidase (DCP; Dcp II; peptidyl dipeptidase; EC 3.4.15.5). This metal-binding M3A family also includes oligopeptidase A (OpdA; EC 3.4.24.70). DCP cleaves dipeptides off the C-termini of various peptides and proteins, the smallest substrate being N-blocked tripeptides and unblocked tetrapeptides. DCP from Escherichia coli is inhibited by the anti-hypertensive drug captopril, an inhibitor of the mammalian angiotensin converting enzyme (ACE, also called peptidyl dipeptidase A). OpdA may play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. It can also cleave N-acetyl-L-Ala. This family also includes Arabidopsis thaliana organellar oligopeptidase OOP (At5g65620), which plays a role in targeting peptide degradation in mitochondria and chloroplasts; it degrades peptide substrates that are between 8 to 23 amino acid residues, and shows a weak preference for hydrophobic residues (F/L) at the P1 position.


:

Pssm-ID: 341051 [Multi-domain]  Cd Length: 653  Bit Score: 955.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 154 EPTWPKLVEPLEKIVDRLTVVWGMINHLKAVKDTPELRAAIEDVQPEKVKFQLRLGQSKPIYNAFKAIRESPDWSSLSEA 233
Cdd:cd06456    27 PPTFENTIEPLERAGEPLDRVWGVFSHLNSVNNSDELRAAYEEVLPLLSAHSDAIGQNEALFARVKALYDSREALGLDPE 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 234 RQRLVEAQIKEAVLIGIALDDEKREEFNKIEQELEKLSHKFSENVLDATKKFEKLITDKKEIEGLPPSALGLFAQAAVSK 313
Cdd:cd06456   107 QKRLLEKTLRDFVLSGAALSEEKKERLAEINEELSELSTKFSQNVLDATNAFSLVITDEAELAGLPESALAAAAEAAKAR 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 314 GHenataenGPWIITLDAPSYLPVMQHAKNRALREEVYRAYLSRASS-GDLDNTAIIDQILKLRLEKAKLLGYNNYAEVS 392
Cdd:cd06456   187 GK-------GGWLFTLDAPSYQPFLTYCDNRELREKVYRAYVTRASDgGEFDNSPIIEEILALRAEKAKLLGYKNYAEYS 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 393 MAMKMA-TVEKAAELLEKLRSASWDAAVQDMEDLKSFAKNQGAaeSDSMTHWDTTFWSERLRESKYDINEEELRPYFSLP 471
Cdd:cd06456   260 LATKMAkSPEAVLEFLEDLAEKAKPAAEKELAELQAFAKEEGG--GDKLEPWDWAYYAEKLRKEKYDLDEEELRPYFPLD 337
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 472 KVMDGLFSLAKTLFGIDIEPADGLaPVWNNDVRFYRVKDSSGNPIAYFYFDPYSRPSeKRGGAWMDEVVSRSRVMAqkgs 551
Cdd:cd06456   338 RVLEGLFELAERLYGITFKERDDV-PVWHPDVRVYEVFDADGELLGLFYLDLYARPG-KRGGAWMDSFRSRSRLLD---- 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 552 SVRLPVAHMVCNQTPPVGDKPSLMTFREVETVFHEFGHALQHMLTKQDEGLVAGIRNIeWDAVELPSQFMENWCYHRDTL 631
Cdd:cd06456   412 SGQLPVAYLVCNFTPPAGGKPALLSHDEVETLFHEFGHALHHLLTDVDYPSVSGTNVV-WDFVELPSQFMENWAWEPEVL 490
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 632 MSIAKHYETGETLPEEVYKKLLAARTFRAGSFSLRQLKFASVDLELHTKYVPGGPESIYDVDQRVSVKTQVIPPLPEDRF 711
Cdd:cd06456   491 KLYARHYETGEPLPDELIEKLLAARNFNAGFATLRQLAFALLDLALHSLYDPEAPEDVDAFEREVLKEYGVLPPIPPRRR 570
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 712 LCSFSHIFAGGYAAGYYSYKWAEVLSADAFSAFEDAGLDDikavKETGQRFRNTILALGGGKAPLKVFVEFRGREPSPEP 791
Cdd:cd06456   571 SCSFSHIFSGGYAAGYYSYLWAEVLAADAFSAFEEAGGFN----RETGRRFRDTILSRGGSRDPMELFRAFRGRDPDIDA 646

                  ....*..
gi 1063743433 792 LLRHNGL 798
Cdd:cd06456   647 LLRRRGL 653
 
Name Accession Description Interval E-value
M3A_DCP cd06456
Peptidase family M3, dipeptidyl carboxypeptidase (DCP); Peptidase family M3 dipeptidyl ...
154-798 0e+00

Peptidase family M3, dipeptidyl carboxypeptidase (DCP); Peptidase family M3 dipeptidyl carboxypeptidase (DCP; Dcp II; peptidyl dipeptidase; EC 3.4.15.5). This metal-binding M3A family also includes oligopeptidase A (OpdA; EC 3.4.24.70). DCP cleaves dipeptides off the C-termini of various peptides and proteins, the smallest substrate being N-blocked tripeptides and unblocked tetrapeptides. DCP from Escherichia coli is inhibited by the anti-hypertensive drug captopril, an inhibitor of the mammalian angiotensin converting enzyme (ACE, also called peptidyl dipeptidase A). OpdA may play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. It can also cleave N-acetyl-L-Ala. This family also includes Arabidopsis thaliana organellar oligopeptidase OOP (At5g65620), which plays a role in targeting peptide degradation in mitochondria and chloroplasts; it degrades peptide substrates that are between 8 to 23 amino acid residues, and shows a weak preference for hydrophobic residues (F/L) at the P1 position.


Pssm-ID: 341051 [Multi-domain]  Cd Length: 653  Bit Score: 955.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 154 EPTWPKLVEPLEKIVDRLTVVWGMINHLKAVKDTPELRAAIEDVQPEKVKFQLRLGQSKPIYNAFKAIRESPDWSSLSEA 233
Cdd:cd06456    27 PPTFENTIEPLERAGEPLDRVWGVFSHLNSVNNSDELRAAYEEVLPLLSAHSDAIGQNEALFARVKALYDSREALGLDPE 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 234 RQRLVEAQIKEAVLIGIALDDEKREEFNKIEQELEKLSHKFSENVLDATKKFEKLITDKKEIEGLPPSALGLFAQAAVSK 313
Cdd:cd06456   107 QKRLLEKTLRDFVLSGAALSEEKKERLAEINEELSELSTKFSQNVLDATNAFSLVITDEAELAGLPESALAAAAEAAKAR 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 314 GHenataenGPWIITLDAPSYLPVMQHAKNRALREEVYRAYLSRASS-GDLDNTAIIDQILKLRLEKAKLLGYNNYAEVS 392
Cdd:cd06456   187 GK-------GGWLFTLDAPSYQPFLTYCDNRELREKVYRAYVTRASDgGEFDNSPIIEEILALRAEKAKLLGYKNYAEYS 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 393 MAMKMA-TVEKAAELLEKLRSASWDAAVQDMEDLKSFAKNQGAaeSDSMTHWDTTFWSERLRESKYDINEEELRPYFSLP 471
Cdd:cd06456   260 LATKMAkSPEAVLEFLEDLAEKAKPAAEKELAELQAFAKEEGG--GDKLEPWDWAYYAEKLRKEKYDLDEEELRPYFPLD 337
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 472 KVMDGLFSLAKTLFGIDIEPADGLaPVWNNDVRFYRVKDSSGNPIAYFYFDPYSRPSeKRGGAWMDEVVSRSRVMAqkgs 551
Cdd:cd06456   338 RVLEGLFELAERLYGITFKERDDV-PVWHPDVRVYEVFDADGELLGLFYLDLYARPG-KRGGAWMDSFRSRSRLLD---- 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 552 SVRLPVAHMVCNQTPPVGDKPSLMTFREVETVFHEFGHALQHMLTKQDEGLVAGIRNIeWDAVELPSQFMENWCYHRDTL 631
Cdd:cd06456   412 SGQLPVAYLVCNFTPPAGGKPALLSHDEVETLFHEFGHALHHLLTDVDYPSVSGTNVV-WDFVELPSQFMENWAWEPEVL 490
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 632 MSIAKHYETGETLPEEVYKKLLAARTFRAGSFSLRQLKFASVDLELHTKYVPGGPESIYDVDQRVSVKTQVIPPLPEDRF 711
Cdd:cd06456   491 KLYARHYETGEPLPDELIEKLLAARNFNAGFATLRQLAFALLDLALHSLYDPEAPEDVDAFEREVLKEYGVLPPIPPRRR 570
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 712 LCSFSHIFAGGYAAGYYSYKWAEVLSADAFSAFEDAGLDDikavKETGQRFRNTILALGGGKAPLKVFVEFRGREPSPEP 791
Cdd:cd06456   571 SCSFSHIFSGGYAAGYYSYLWAEVLAADAFSAFEEAGGFN----RETGRRFRDTILSRGGSRDPMELFRAFRGRDPDIDA 646

                  ....*..
gi 1063743433 792 LLRHNGL 798
Cdd:cd06456   647 LLRRRGL 653
Dcp COG0339
Zn-dependent oligopeptidase, M3 family [Posttranslational modification, protein turnover, ...
108-801 0e+00

Zn-dependent oligopeptidase, M3 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440108 [Multi-domain]  Cd Length: 682  Bit Score: 954.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 108 TLSSNPLLQD----FDFPPFDSVDASHVRPGIRALLQHLEAELEELEKSVE-PTWPKLVEPLEKIVDRLTVVWGMINHLK 182
Cdd:COG0339     2 AAMTNPLLDPstlpYGLPPFDAIKPEHFEPAFEAALAEARAEIEAIAANPEaPTFENTIEALERSGERLSRVWSVFSHLN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 183 AVKDTPELRAAIEDVQPEKVKFQLRLGQSKPIYNAFKAIRESPDWSSLSEARQRLVEAQIKEAVLIGIALDDEKREEFNK 262
Cdd:COG0339    82 SVDTNPELRAAYNEVLPKLSAHSDEIGLNEALFARIKALYDSRDFLGLDPEQKRLLENTLRDFVLSGAALPEEDKARLRE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 263 IEQELEKLSHKFSENVLDATKKFEKLITDKKEIEGLPPSALGLFAQAAVSKGHENataengpWIITLDAPSYLPVMQHAK 342
Cdd:COG0339   162 INEELAELSTKFSQNVLDATNAWALVVTDEAELAGLPESAIAAAAAAAKARGLEG-------WLITLDNPSYQPVLTYAD 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 343 NRALREEVYRAYLSRASS-GDLDNTAIIDQILKLRLEKAKLLGYNNYAEVSMAMKMA-TVEKAAELLEKLRSASWDAAVQ 420
Cdd:COG0339   235 NRELREKLYRAYVTRASDgGEFDNRPIIAEILALRAEKAKLLGYANYAEYSLADKMAkTPEAVLDFLRDLAPAAKPAAER 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 421 DMEDLKSFAKNQGAAesDSMTHWDTTFWSERLRESKYDINEEELRPYFSLPKVMDGLFSLAKTLFGIDIEPADGLaPVWN 500
Cdd:COG0339   315 ELAELQAFAAEEGGI--FDLEPWDWAYYAEKLRQARYDLDEEELKPYFPLDRVLDGLFEVAERLYGLTFKERKDV-PVYH 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 501 NDVRFYRVKDSSGNPIAYFYFDPYSRPSeKRGGAWMDEVVSRSRvmaqKGSSVRLPVAHMVCNQTPPVGDKPSLMTFREV 580
Cdd:COG0339   392 PDVRVFEVFDADGELLGLFYLDLYAREG-KRGGAWMDSFRSQSR----LDGELQLPVAYNVCNFTKPVGGKPALLTHDEV 466
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 581 ETVFHEFGHALQHMLTKQDEGLVAGIrNIEWDAVELPSQFMENWCYHRDTLMSIAKHYETGETLPEEVYKKLLAARTFRA 660
Cdd:COG0339   467 TTLFHEFGHALHGMLTDVDYPSLSGT-NVPWDFVELPSQFMENWCWEPEVLALFARHYETGEPLPDELLDKLLAARNFNS 545
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 661 GSFSLRQLKFASVDLELHTKYVPGGPESIYDVDQRVSVKTQVIPPLPEDRFLCSFSHIFAGGYAAGYYSYKWAEVLSADA 740
Cdd:COG0339   546 GFATLRQLEFALLDMALHTLYDPEAGADVLAFEAEVLAEVGVLPPVPPRRFSTYFSHIFAGGYAAGYYSYKWAEVLDADA 625
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063743433 741 FSAFEDAGLDDikavKETGQRFRNTILALGGGKAPLKVFVEFRGREPSPEPLLRHNGLLAA 801
Cdd:COG0339   626 FSAFEEAGIFD----RETGQRFRDEILSRGGSRDPMELFKAFRGREPSIDALLRHRGLAAA 682
PRK10911 PRK10911
oligopeptidase A; Provisional
111-798 0e+00

oligopeptidase A; Provisional


Pssm-ID: 182832 [Multi-domain]  Cd Length: 680  Bit Score: 631.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 111 SNPLLQDFDFPPFDSVDASHVRPGIRALLQHLEAELEELEKSVEP-TWPKLVEPLEKIVDRLTVVWGMINHLKAVKDTPE 189
Cdd:PRK10911    2 TNPLLTPFSLPPFSAIKPEHVVPAVTKALNDCREAVERVVAQGAPyTWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSPE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 190 LRAAIEDVQPEKVKFQLRLGQSKPIYNAFKAIRESPDWSSLSEARQRLVEAQIKEAVLIGIALDDEKREEFNKIEQELEK 269
Cdd:PRK10911   82 LREAYEQTLPLLSEYSTWVGQHEGLYQAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIAARLSE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 270 LSHKFSENVLDATKKFEKLITDKKEIEGLPPSALglfaqaAVSKGHENATAENGpWIITLDAPSYLPVMQHAKNRALREE 349
Cdd:PRK10911  162 LGNQYSNNVLDATMGWTKLITDEAELAGMPESAL------AAAKAQAEAKEQEG-YLLTLDIPSYLPVMTYCDNQALREE 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 350 VYRAYLSRAS-----SGDLDNTAIIDQILKLRLEKAKLLGYNNYAEVSMAMKMA-TVEKAAELLEKLRSASWDAAVQDME 423
Cdd:PRK10911  235 MYRAYSTRASdqgpnAGKWDNSEVMEEILALRHELAQLLGFENYADKSLATKMAeNPQQVLDFLTDLAKRARPQGEKELA 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 424 DLKSFAKNQGAAesDSMTHWDTTFWSERLRESKYDINEEELRPYFSLPKVMDGLFSLAKTLFGIDIEPADGLaPVWNNDV 503
Cdd:PRK10911  315 QLRAFAKAEFGV--DELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERKDV-DVWHPDV 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 504 RFYRVKDSSGNPIAYFYFDPYSRpSEKRGGAWMDEVVSRsrvMAQKGSSVRLPVAHMVCNQTPPVGDKPSLMTFREVETV 583
Cdd:PRK10911  392 RFFELYDENNELRGSFYLDLYAR-ENKRGGAWMDDCVGQ---MRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITL 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 584 FHEFGHALQHMLTKQDEGLVAGIRNIEWDAVELPSQFMENWCYHRDTLMSIAKHYETGETLPEEVYKKLLAARTFRAGSF 663
Cdd:PRK10911  468 FHEFGHGLHHMLTRIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALF 547
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 664 SLRQLKFASVDLELHTKYVPGGPESIYDVDQRVSVKTQVIPPLPEDRFLCSFSHIFAGGYAAGYYSYKWAEVLSADAFSA 743
Cdd:PRK10911  548 ILRQLEFGLFDFRLHAEFDPDQGAKILETLAEIKKQVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSR 627
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063743433 744 FEDAGLDDikavKETGQRFRNTILALGGGKAPLKVFVEFRGREPSPEPLLRHNGL 798
Cdd:PRK10911  628 FEEEGIFN----RETGQSFLDNILSRGGSEEPMELFKRFRGREPQLDAMLEHYGI 678
Peptidase_M3 pfam01432
Peptidase family M3; This is the Thimet oligopeptidase family, large family of mammalian and ...
337-798 1.34e-156

Peptidase family M3; This is the Thimet oligopeptidase family, large family of mammalian and bacterial oligopeptidases that cleave medium sized peptides. The group also contains mitochondrial intermediate peptidase which is encoded by nuclear DNA but functions within the mitochondria to remove the leader sequence.


Pssm-ID: 396149 [Multi-domain]  Cd Length: 450  Bit Score: 463.78  E-value: 1.34e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 337 VMQHAKNRALREEVYRAYLSRASSGD--LDNTAIIDQILKLRLEKAKLLGYNNYAEVSMAMKMA-TVEKAAELLEKLRSA 413
Cdd:pfam01432   1 LLKESPDRETRKKAYRAFYSRAEAYRntLENSALLEELLKLRAELAKLLGYPSYAEASLEDKMAkIPETVYDFLEELVNK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 414 SWDAAVQDMEDLKSFAKNQGaaESDSMTHWDTTFWSERLRESKYD-INEEELRPYFSLPKVM-DGLFSLAKTLFGIDIEP 491
Cdd:pfam01432  81 LRPLLHRELELLKKLKKKEL--GLEELQPWDVAYYSEKQREELYDpLDQEELRPYFPLEQVLeKGLFGLFERLFGITFVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 492 ADgLAPVWNNDVRFYRVKDS-SGNPIAYFYFDPYSRPSeKRGGAWMDEVVSRSRvmaqkgssvrLPVAHMVCNQTPPVGD 570
Cdd:pfam01432 159 EP-LGEVWHEDVRFYSVFDElSGGLIGEFYLDLYPRKG-KRGGAYSFGLVPGRK----------DPVPYLLCNFTKPSSG 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 571 KPSLMTFREVETVFHEFGHALQHMLTKQDEGLVAGIrNIEWDAVELPSQFMENWCYHRDTLMSIAKHYETGETLPEEVYK 650
Cdd:pfam01432 227 KPSLLTHDDVETLFHEFGHSMHSLLSRTEYSYVSGT-NVPIDFAEIPSQFNENWLWEPLLLNLLSRHYETGEPIPAELLE 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 651 KLLAARTFRAGSFSLRQLKFASVDLELHTKYVPGGPES-IYDVDQRVSVKTQVIPPLPEDRFLCSFSHIFAGGYAAGYYS 729
Cdd:pfam01432 306 KLIKSKNVNAGLFLFRQLMFAAFDQEIHEAAEEDQKLDfLLEEYAELNKKYYGDPVTPDEASPLSFSHIFPHGYAANYYS 385
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063743433 730 YKWAEVLSADAFSAFEDAGLDDikavKETGQRFRNTILALGGGKAPLKVFVEFRGREPSPEPLLRHNGL 798
Cdd:pfam01432 386 YLYATGLALDIFEKFFEQDPLN----RETGLRYYLEFLSRGGSLDPLELLKKFGGRMPSADALLRALGL 450
 
Name Accession Description Interval E-value
M3A_DCP cd06456
Peptidase family M3, dipeptidyl carboxypeptidase (DCP); Peptidase family M3 dipeptidyl ...
154-798 0e+00

Peptidase family M3, dipeptidyl carboxypeptidase (DCP); Peptidase family M3 dipeptidyl carboxypeptidase (DCP; Dcp II; peptidyl dipeptidase; EC 3.4.15.5). This metal-binding M3A family also includes oligopeptidase A (OpdA; EC 3.4.24.70). DCP cleaves dipeptides off the C-termini of various peptides and proteins, the smallest substrate being N-blocked tripeptides and unblocked tetrapeptides. DCP from Escherichia coli is inhibited by the anti-hypertensive drug captopril, an inhibitor of the mammalian angiotensin converting enzyme (ACE, also called peptidyl dipeptidase A). OpdA may play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. It can also cleave N-acetyl-L-Ala. This family also includes Arabidopsis thaliana organellar oligopeptidase OOP (At5g65620), which plays a role in targeting peptide degradation in mitochondria and chloroplasts; it degrades peptide substrates that are between 8 to 23 amino acid residues, and shows a weak preference for hydrophobic residues (F/L) at the P1 position.


Pssm-ID: 341051 [Multi-domain]  Cd Length: 653  Bit Score: 955.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 154 EPTWPKLVEPLEKIVDRLTVVWGMINHLKAVKDTPELRAAIEDVQPEKVKFQLRLGQSKPIYNAFKAIRESPDWSSLSEA 233
Cdd:cd06456    27 PPTFENTIEPLERAGEPLDRVWGVFSHLNSVNNSDELRAAYEEVLPLLSAHSDAIGQNEALFARVKALYDSREALGLDPE 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 234 RQRLVEAQIKEAVLIGIALDDEKREEFNKIEQELEKLSHKFSENVLDATKKFEKLITDKKEIEGLPPSALGLFAQAAVSK 313
Cdd:cd06456   107 QKRLLEKTLRDFVLSGAALSEEKKERLAEINEELSELSTKFSQNVLDATNAFSLVITDEAELAGLPESALAAAAEAAKAR 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 314 GHenataenGPWIITLDAPSYLPVMQHAKNRALREEVYRAYLSRASS-GDLDNTAIIDQILKLRLEKAKLLGYNNYAEVS 392
Cdd:cd06456   187 GK-------GGWLFTLDAPSYQPFLTYCDNRELREKVYRAYVTRASDgGEFDNSPIIEEILALRAEKAKLLGYKNYAEYS 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 393 MAMKMA-TVEKAAELLEKLRSASWDAAVQDMEDLKSFAKNQGAaeSDSMTHWDTTFWSERLRESKYDINEEELRPYFSLP 471
Cdd:cd06456   260 LATKMAkSPEAVLEFLEDLAEKAKPAAEKELAELQAFAKEEGG--GDKLEPWDWAYYAEKLRKEKYDLDEEELRPYFPLD 337
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 472 KVMDGLFSLAKTLFGIDIEPADGLaPVWNNDVRFYRVKDSSGNPIAYFYFDPYSRPSeKRGGAWMDEVVSRSRVMAqkgs 551
Cdd:cd06456   338 RVLEGLFELAERLYGITFKERDDV-PVWHPDVRVYEVFDADGELLGLFYLDLYARPG-KRGGAWMDSFRSRSRLLD---- 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 552 SVRLPVAHMVCNQTPPVGDKPSLMTFREVETVFHEFGHALQHMLTKQDEGLVAGIRNIeWDAVELPSQFMENWCYHRDTL 631
Cdd:cd06456   412 SGQLPVAYLVCNFTPPAGGKPALLSHDEVETLFHEFGHALHHLLTDVDYPSVSGTNVV-WDFVELPSQFMENWAWEPEVL 490
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 632 MSIAKHYETGETLPEEVYKKLLAARTFRAGSFSLRQLKFASVDLELHTKYVPGGPESIYDVDQRVSVKTQVIPPLPEDRF 711
Cdd:cd06456   491 KLYARHYETGEPLPDELIEKLLAARNFNAGFATLRQLAFALLDLALHSLYDPEAPEDVDAFEREVLKEYGVLPPIPPRRR 570
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 712 LCSFSHIFAGGYAAGYYSYKWAEVLSADAFSAFEDAGLDDikavKETGQRFRNTILALGGGKAPLKVFVEFRGREPSPEP 791
Cdd:cd06456   571 SCSFSHIFSGGYAAGYYSYLWAEVLAADAFSAFEEAGGFN----RETGRRFRDTILSRGGSRDPMELFRAFRGRDPDIDA 646

                  ....*..
gi 1063743433 792 LLRHNGL 798
Cdd:cd06456   647 LLRRRGL 653
Dcp COG0339
Zn-dependent oligopeptidase, M3 family [Posttranslational modification, protein turnover, ...
108-801 0e+00

Zn-dependent oligopeptidase, M3 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440108 [Multi-domain]  Cd Length: 682  Bit Score: 954.11  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 108 TLSSNPLLQD----FDFPPFDSVDASHVRPGIRALLQHLEAELEELEKSVE-PTWPKLVEPLEKIVDRLTVVWGMINHLK 182
Cdd:COG0339     2 AAMTNPLLDPstlpYGLPPFDAIKPEHFEPAFEAALAEARAEIEAIAANPEaPTFENTIEALERSGERLSRVWSVFSHLN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 183 AVKDTPELRAAIEDVQPEKVKFQLRLGQSKPIYNAFKAIRESPDWSSLSEARQRLVEAQIKEAVLIGIALDDEKREEFNK 262
Cdd:COG0339    82 SVDTNPELRAAYNEVLPKLSAHSDEIGLNEALFARIKALYDSRDFLGLDPEQKRLLENTLRDFVLSGAALPEEDKARLRE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 263 IEQELEKLSHKFSENVLDATKKFEKLITDKKEIEGLPPSALGLFAQAAVSKGHENataengpWIITLDAPSYLPVMQHAK 342
Cdd:COG0339   162 INEELAELSTKFSQNVLDATNAWALVVTDEAELAGLPESAIAAAAAAAKARGLEG-------WLITLDNPSYQPVLTYAD 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 343 NRALREEVYRAYLSRASS-GDLDNTAIIDQILKLRLEKAKLLGYNNYAEVSMAMKMA-TVEKAAELLEKLRSASWDAAVQ 420
Cdd:COG0339   235 NRELREKLYRAYVTRASDgGEFDNRPIIAEILALRAEKAKLLGYANYAEYSLADKMAkTPEAVLDFLRDLAPAAKPAAER 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 421 DMEDLKSFAKNQGAAesDSMTHWDTTFWSERLRESKYDINEEELRPYFSLPKVMDGLFSLAKTLFGIDIEPADGLaPVWN 500
Cdd:COG0339   315 ELAELQAFAAEEGGI--FDLEPWDWAYYAEKLRQARYDLDEEELKPYFPLDRVLDGLFEVAERLYGLTFKERKDV-PVYH 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 501 NDVRFYRVKDSSGNPIAYFYFDPYSRPSeKRGGAWMDEVVSRSRvmaqKGSSVRLPVAHMVCNQTPPVGDKPSLMTFREV 580
Cdd:COG0339   392 PDVRVFEVFDADGELLGLFYLDLYAREG-KRGGAWMDSFRSQSR----LDGELQLPVAYNVCNFTKPVGGKPALLTHDEV 466
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 581 ETVFHEFGHALQHMLTKQDEGLVAGIrNIEWDAVELPSQFMENWCYHRDTLMSIAKHYETGETLPEEVYKKLLAARTFRA 660
Cdd:COG0339   467 TTLFHEFGHALHGMLTDVDYPSLSGT-NVPWDFVELPSQFMENWCWEPEVLALFARHYETGEPLPDELLDKLLAARNFNS 545
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 661 GSFSLRQLKFASVDLELHTKYVPGGPESIYDVDQRVSVKTQVIPPLPEDRFLCSFSHIFAGGYAAGYYSYKWAEVLSADA 740
Cdd:COG0339   546 GFATLRQLEFALLDMALHTLYDPEAGADVLAFEAEVLAEVGVLPPVPPRRFSTYFSHIFAGGYAAGYYSYKWAEVLDADA 625
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063743433 741 FSAFEDAGLDDikavKETGQRFRNTILALGGGKAPLKVFVEFRGREPSPEPLLRHNGLLAA 801
Cdd:COG0339   626 FSAFEEAGIFD----RETGQRFRDEILSRGGSRDPMELFKAFRGREPSIDALLRHRGLAAA 682
PRK10911 PRK10911
oligopeptidase A; Provisional
111-798 0e+00

oligopeptidase A; Provisional


Pssm-ID: 182832 [Multi-domain]  Cd Length: 680  Bit Score: 631.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 111 SNPLLQDFDFPPFDSVDASHVRPGIRALLQHLEAELEELEKSVEP-TWPKLVEPLEKIVDRLTVVWGMINHLKAVKDTPE 189
Cdd:PRK10911    2 TNPLLTPFSLPPFSAIKPEHVVPAVTKALNDCREAVERVVAQGAPyTWENLCQPLAEVDDVLGRIFSPVSHLNSVKNSPE 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 190 LRAAIEDVQPEKVKFQLRLGQSKPIYNAFKAIRESPDWSSLSEARQRLVEAQIKEAVLIGIALDDEKREEFNKIEQELEK 269
Cdd:PRK10911   82 LREAYEQTLPLLSEYSTWVGQHEGLYQAYRDLRDGDHYATLNTAQKKAVDNALRDFELSGIGLPKEKQQRYGEIAARLSE 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 270 LSHKFSENVLDATKKFEKLITDKKEIEGLPPSALglfaqaAVSKGHENATAENGpWIITLDAPSYLPVMQHAKNRALREE 349
Cdd:PRK10911  162 LGNQYSNNVLDATMGWTKLITDEAELAGMPESAL------AAAKAQAEAKEQEG-YLLTLDIPSYLPVMTYCDNQALREE 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 350 VYRAYLSRAS-----SGDLDNTAIIDQILKLRLEKAKLLGYNNYAEVSMAMKMA-TVEKAAELLEKLRSASWDAAVQDME 423
Cdd:PRK10911  235 MYRAYSTRASdqgpnAGKWDNSEVMEEILALRHELAQLLGFENYADKSLATKMAeNPQQVLDFLTDLAKRARPQGEKELA 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 424 DLKSFAKNQGAAesDSMTHWDTTFWSERLRESKYDINEEELRPYFSLPKVMDGLFSLAKTLFGIDIEPADGLaPVWNNDV 503
Cdd:PRK10911  315 QLRAFAKAEFGV--DELQPWDIAYYSEKQKQHLYSISDEQLRPYFPENKAVNGLFEVVKRIYGITAKERKDV-DVWHPDV 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 504 RFYRVKDSSGNPIAYFYFDPYSRpSEKRGGAWMDEVVSRsrvMAQKGSSVRLPVAHMVCNQTPPVGDKPSLMTFREVETV 583
Cdd:PRK10911  392 RFFELYDENNELRGSFYLDLYAR-ENKRGGAWMDDCVGQ---MRKADGSLQKPVAYLTCNFNRPVNGKPALFTHDEVITL 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 584 FHEFGHALQHMLTKQDEGLVAGIRNIEWDAVELPSQFMENWCYHRDTLMSIAKHYETGETLPEEVYKKLLAARTFRAGSF 663
Cdd:PRK10911  468 FHEFGHGLHHMLTRIETAGVSGISGVPWDAVELPSQFMENWCWEPEALAFISGHYETGEPLPKELLDKMLAAKNYQAALF 547
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 664 SLRQLKFASVDLELHTKYVPGGPESIYDVDQRVSVKTQVIPPLPEDRFLCSFSHIFAGGYAAGYYSYKWAEVLSADAFSA 743
Cdd:PRK10911  548 ILRQLEFGLFDFRLHAEFDPDQGAKILETLAEIKKQVAVVPSPSWGRFPHAFSHIFAGGYAAGYYSYLWADVLAADAFSR 627
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063743433 744 FEDAGLDDikavKETGQRFRNTILALGGGKAPLKVFVEFRGREPSPEPLLRHNGL 798
Cdd:PRK10911  628 FEEEGIFN----RETGQSFLDNILSRGGSEEPMELFKRFRGREPQLDAMLEHYGI 678
M3A_TOP cd06455
Peptidase M3 thimet oligopeptidase (TOP), also includes neurolysin; Peptidase M3 Thimet ...
154-795 3.77e-173

Peptidase M3 thimet oligopeptidase (TOP), also includes neurolysin; Peptidase M3 Thimet oligopeptidase (TOP; PZ-peptidase; endo-oligopeptidase A; endopeptidase 24.15; soluble metallo-endopeptidase; EC 3.4.24.15) family also includes neurolysin (endopeptidase 24.16, microsomal endopeptidase, mitochondrial oligopeptidase M, neurotensin endopeptidase, soluble angiotensin II-binding protein, thimet oligopeptidase II) which hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. TOP and neurolysin are neuropeptidases expressed abundantly in the testis, but are also found in the liver, lung and kidney. They are involved in the metabolism of neuropeptides under 20 amino acid residues long and cleave most bioactive peptides at the same sites, but recognize different positions on some naturally occurring and synthetic peptides; they cleave at distinct sites on the 13-residue bioactive peptide neurotensin, which modulates central dopaminergic and cholinergic circuits. TOP has been shown to degrade peptides released by the proteasome, limiting the extent of antigen presentation by major histocompatibility complex class I molecules, and has been associated with amyloid protein precursor processing.


Pssm-ID: 341050 [Multi-domain]  Cd Length: 642  Bit Score: 513.21  E-value: 3.77e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 154 EPTWPKLVEPLEKIVDRLTVVWGMINHLKAVKDTPELRAAIEDVQPEKVKFQLRLGQSKPIYNAFKAIRESPDwSSLSEA 233
Cdd:cd06455    25 DATFENTLLPLDEAENELSDASGPLTFLQSVSPDKEVRDASSEAEKKLSAFSIELSMREDLYRLVKAVYDKNE-KKLDAE 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 234 RQRLVEAQIKEAVLIGIALDDEKREEFNKIEQELEKLSHKFSENVLDATKKFEKlitDKKEIEGLPPSALglfaqaavsK 313
Cdd:cd06455   104 SRRLLEKLLRDFRRNGLGLPDEKRERLKELKKEISELSIEFSKNLNEDNTGIWF---TEEELEGVPEDFL---------D 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 314 GHEnaTAENGPWIITLDAPSYLPVMQHAKNRALREEVYRAYLSRASSgdlDNTAIIDQILKLRLEKAKLLGYNNYAEVSM 393
Cdd:cd06455   172 RLK--KDDDGKYKVTLKYPDYFPVMKYAKNPETRKRMYLAFENRAYP---ENVPLLEEIVALRDELARLLGYKSHADYVL 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 394 AMKMA-TVEKAAELLEKLRSASWDAAVQDMEDLKSFAKN--QGAAESDSMTHWDTTFWSERLRESKYDINEEELRPYFSL 470
Cdd:cd06455   247 EDRMAkTPEAVEAFLDDLREKLKPLAEKELAELLALKKEdlPEAGLPGKLYPWDLAYYSRLLKKEEYSVDEEKIREYFPL 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 471 PKVMDGLFSLAKTLFGIDIEPADGlAPVWNNDVRFYRVKDS-SGNPIAYFYFDPYSRPSeKRGGAWMDEVVSRSRvmaQK 549
Cdd:cd06455   327 EHVVDGMLDIYEELFGLRFEEVDG-APVWHPDVRLYAVWDDdTGEFLGYLYLDLFPREG-KYGHAANFPLQPGFT---KP 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 550 GSSVRLPVAHMVCNQTPPVGDKPSLMTFREVETVFHEFGHALQHMLTKQDEGLVAGIRnIEWDAVELPSQFMENWCYHRD 629
Cdd:cd06455   402 DGSRQYPVTALVCNFPKPTADKPSLLKHDEVVTLFHEFGHAMHDLLSRTKYARFHGTS-VERDFVEAPSQMLENWCWDPE 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 630 TLMSIAKHYETGETLPEEVYKKLLAARTFRAGSFSLRQLKFASVDLELHTkyvPGGPESI------YDVDQRVsvkTQVI 703
Cdd:cd06455   481 VLKRLSKHYKTGEPLPDELIEKLIKSRNFNSGLFYLRQLFLALFDLALHT---PDSHEALdltklwNELREEI---TLIP 554
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 704 PPLPEDRFLCSFSHIfAGGYAAGYYSYKWAEVLSADAFSAFEDAGLDDikavKETGQRFRNTILALGGGKAPLKVFVEFR 783
Cdd:cd06455   555 GPPEGTHGYASFGHL-MGGYDAGYYGYLWSEVFAADMFYTFFKADPLN----PEVGRRYRDKVLEPGGSRDEMELLEDFL 629
                         650
                  ....*....|..
gi 1063743433 784 GREPSPEPLLRH 795
Cdd:cd06455   630 GREPNSDAFLKE 641
Peptidase_M3 pfam01432
Peptidase family M3; This is the Thimet oligopeptidase family, large family of mammalian and ...
337-798 1.34e-156

Peptidase family M3; This is the Thimet oligopeptidase family, large family of mammalian and bacterial oligopeptidases that cleave medium sized peptides. The group also contains mitochondrial intermediate peptidase which is encoded by nuclear DNA but functions within the mitochondria to remove the leader sequence.


Pssm-ID: 396149 [Multi-domain]  Cd Length: 450  Bit Score: 463.78  E-value: 1.34e-156
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 337 VMQHAKNRALREEVYRAYLSRASSGD--LDNTAIIDQILKLRLEKAKLLGYNNYAEVSMAMKMA-TVEKAAELLEKLRSA 413
Cdd:pfam01432   1 LLKESPDRETRKKAYRAFYSRAEAYRntLENSALLEELLKLRAELAKLLGYPSYAEASLEDKMAkIPETVYDFLEELVNK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 414 SWDAAVQDMEDLKSFAKNQGaaESDSMTHWDTTFWSERLRESKYD-INEEELRPYFSLPKVM-DGLFSLAKTLFGIDIEP 491
Cdd:pfam01432  81 LRPLLHRELELLKKLKKKEL--GLEELQPWDVAYYSEKQREELYDpLDQEELRPYFPLEQVLeKGLFGLFERLFGITFVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 492 ADgLAPVWNNDVRFYRVKDS-SGNPIAYFYFDPYSRPSeKRGGAWMDEVVSRSRvmaqkgssvrLPVAHMVCNQTPPVGD 570
Cdd:pfam01432 159 EP-LGEVWHEDVRFYSVFDElSGGLIGEFYLDLYPRKG-KRGGAYSFGLVPGRK----------DPVPYLLCNFTKPSSG 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 571 KPSLMTFREVETVFHEFGHALQHMLTKQDEGLVAGIrNIEWDAVELPSQFMENWCYHRDTLMSIAKHYETGETLPEEVYK 650
Cdd:pfam01432 227 KPSLLTHDDVETLFHEFGHSMHSLLSRTEYSYVSGT-NVPIDFAEIPSQFNENWLWEPLLLNLLSRHYETGEPIPAELLE 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 651 KLLAARTFRAGSFSLRQLKFASVDLELHTKYVPGGPES-IYDVDQRVSVKTQVIPPLPEDRFLCSFSHIFAGGYAAGYYS 729
Cdd:pfam01432 306 KLIKSKNVNAGLFLFRQLMFAAFDQEIHEAAEEDQKLDfLLEEYAELNKKYYGDPVTPDEASPLSFSHIFPHGYAANYYS 385
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063743433 730 YKWAEVLSADAFSAFEDAGLDDikavKETGQRFRNTILALGGGKAPLKVFVEFRGREPSPEPLLRHNGL 798
Cdd:pfam01432 386 YLYATGLALDIFEKFFEQDPLN----RETGLRYYLEFLSRGGSLDPLELLKKFGGRMPSADALLRALGL 450
M3A cd09605
Peptidase M3A family includes thimet oligopeptidase, dipeptidyl carboxypeptidase and ...
154-795 7.99e-114

Peptidase M3A family includes thimet oligopeptidase, dipeptidyl carboxypeptidase and mitochondrial intermediate peptidase; The M3-like family also called neurolysin-like family, is part of the "zincins" metallopeptidases, and includes M3, M2 and M32 families of metallopeptidases. The M3 family is subdivided into two subfamilies: the widespread M3A, represented by this CD, which comprises a number of high-molecular mass endo- and exopeptidases from bacteria, archaea, protozoa, fungi, plants and animals, and the small M3B, whose members are enzymes primarily from bacteria. Well-known mammalian/eukaryotic M3A endopeptidases are the thimet oligopeptidase (TOP; endopeptidase 3.4.24.15), neurolysin (alias endopeptidase 3.4.24.16), and the mitochondrial intermediate peptidase. The first two are intracellular oligopeptidases, which act only on relatively short substrates of less than 20 amino acid residues, while the latter cleaves N-terminal octapeptides from proteins during their import into the mitochondria. The M3A subfamily also contains several bacterial endopeptidases, called oligopeptidases A, as well as a large number of bacterial carboxypeptidases, called dipeptidyl peptidases (Dcp; Dcp II; peptidyl dipeptidase; EC 3.4.15.5). The peptidases in the M3 family contain the HEXXH motif that forms part of the active site in conjunction with a C-terminally-located Glutamic acid (Glu) residue. A single zinc ion is ligated by the side-chains of the two Histidine (His) residues, and the more C-terminal Glu. Most of the peptidases are synthesized without signal peptides or propeptides, and function intracellularly.


Pssm-ID: 341068 [Multi-domain]  Cd Length: 587  Bit Score: 358.01  E-value: 7.99e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 154 EPTWPKLVEPLEKIVDRLTVVWGMINHLKAVKDTPELRAAIEDVQPEKVKFQLRLGQSKPIYNAFKAIRESPDWSSL-SE 232
Cdd:cd09605    25 TPPYENTLLALADLEVTLTRVRDLLDFPQHAHPEPEFREASEEADKKLSEFDEEMSMNEDLYQRIVKLQEDKKLVSLdPE 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 233 ARqRLVEAQIKEAVLIGIALDDEKREEFNKIEQELEKLSHKFSENVLDATkkfeklitdkkeieglppsalglfaqaavs 312
Cdd:cd09605   105 AR-RYLELFIKDFERNGLHLDKEKRKRIKDLNKKISDLCSDFNKNLNPET------------------------------ 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 313 kghenataengpwiitldapsylpvmqhaknralREEVYRAYLSRASSgdlDNTAIIDQILKLRLEKAKLLGYNNYAEVS 392
Cdd:cd09605   154 ----------------------------------REKAEKAFLTRCKA---ENLAILQELLSLRAQLAKLLGYSTHADRV 196
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 393 MAMKMA-TVEKAAELLEKLRSASWDAAVQDMEDLKSFAKNQGAAESDSMThWDTTFWSERLRESKYDINEEELRPYFSLP 471
Cdd:cd09605   197 LEGNMAkTPETVAQFLDELSQKLKPRGEKEREMILGLKMKECEQDGEIMP-WDPPYYMGQVREERYNVDQSLLKPYFPLG 275
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 472 KVMDGLFSLAKTLFGIDIEPADGlAPVWNNDVRFYRVKDSSGNPIAYFYFDPYSRPSeKRGGAWMDEVVSRSrvMAQKGS 551
Cdd:cd09605   276 VVTEGLLIIYNELLGISFYAEQD-AEVWHEDVRLYTVVDEAEEVLGYFYLDFFPREG-KYGHAACFGLQPGC--LKEDGS 351
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 552 SvRLPVAHMVCNQTPPVGDKPSLMTFREVETVFHEFGHALQHMLTKQDEGLVAGIrNIEWDAVELPSQFMENWCYHRDTL 631
Cdd:cd09605   352 R-QLPVAALVLNFPKPSAGSPSLLTHDEVRTLFHEFGHVMHQLCARTRYAHFSGT-NVPTDFVEVPSQMLENWAWDVNQF 429
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 632 MSIAKHYETGETLPEEVYKKLLAARTFRAGSFSLRQLKFASVDLELHTKyvpggpESIYDVDQRVSVKTQV----IPPLP 707
Cdd:cd09605   430 ARHSRHYQSGAPLPDELLEKLCESRLVNTGLDMLRQIVLAKLDQILHTK------HPLRNDTADELAELCEeilgLPATP 503
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 708 EDRFLCSFSHIFaGGYAAGYYSYKWAEVLSADAF-SAFEDAGLDdikavKETGQRFRNTILALGGGKAPLKVFVEFRGRE 786
Cdd:cd09605   504 GTNMPATFGHLA-GGYDAQYYGYLWSEVVAMDMFhECFKQEPLN-----REVGMRYRREILAPGGSEDPMLMLRGFLQKC 577

                  ....*....
gi 1063743433 787 PSPEPLLRH 795
Cdd:cd09605   578 PKQSAFLFS 586
PRK10280 PRK10280
peptidyl-dipeptidase Dcp;
110-798 2.10e-104

peptidyl-dipeptidase Dcp;


Pssm-ID: 182353  Cd Length: 681  Bit Score: 336.42  E-value: 2.10e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 110 SSNPLLQD----FDFPPFDSVDASHVRP----GIRALLQHLEAELEELEKsvePTWPKLVEPLEKIVDRLTVVWGMINHL 181
Cdd:PRK10280    3 TMNPFLVQstlpYLAPHFDQIADHHYRPafdeGVRQKRAEIAAIALNPQA---PDFNNTILALEQSGELLTRVTSVFFAM 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 182 KAVKDTPELRAAIEDVQPEKVKFQLRLGQSKPIYNAFKAIRESPDWSSLSEARQRLVEAQIKEAVLIGIALDDEKREEFN 261
Cdd:PRK10280   80 TAAHTNDELQRLDEQFSAELAELANDIYLNGELFARVDAVWQQRESLGLDSESIRLVEVIHQRFVLAGAKLAQADKAKLK 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 262 KIEQELEKLSHKFSENVLDATKKFEKLITDKKEIEGLPPSALGLFAQAAVSKGHENAtaengpWIITLDAPSYLPVMQHA 341
Cdd:PRK10280  160 VLNTEAATLTSQFNQRLLAANKSGGLVVNDIHQLAGLSEQEIALAAEAAREKGLDNR------WLIPLLNTTQQPALAEL 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 342 KNRALREEVYRAYLSRASSGDLDNT-AIIDQILKLRLEKAKLLGYNNYAEVSMAMKMA-TVEKAAELLEKLRSASWDAAV 419
Cdd:PRK10280  234 RDRQTRENLFAAGWTRAEKGDANDTrAIIQRLVEIRAQQAKLLGFPHYAAWKIADQMAkTPEAALNFMREIVPAARQRAS 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 420 QDMEDLKSFAKNQGAAESdsMTHWDTTFWSERLRESKYDINEEELRPYFSLPKVM-DGLFSLAKTLFGID-IEPADglAP 497
Cdd:PRK10280  314 DELASIQAVIDKQQGGFS--AQAWDWAFYAEQVRREKYALDEAQLKPYFELNTVLnEGVFWTANQLFGIKfVERFD--IP 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 498 VWNNDVRFYRVKDSSGNPIAYFYFDPYSRPSeKRGGAWMDEVVSRSRVMAQKgssvrlPVAHMVCNQTPPVGDKPSLMTF 577
Cdd:PRK10280  390 VYHPDVRVWEIFDHNGVGLALFYGDFFARDS-KSGGAWMGNFVEQSTLNETR------PVIYNVCNYQKPAAGQPALLLW 462
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 578 REVETVFHEFGHALQHMLTKQDEGLVAGIrNIEWDAVELPSQFMENWCYHRDTLMSIAKHYETGETLPEEVYKKLLAART 657
Cdd:PRK10280  463 DDVITLFHEFGHTLHGLFARQRYATLSGT-NTPRDFVEFPSQINEHWASHPQVFARYARHYQSGEAMPDELQEKMRNASL 541
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 658 FRAGSFSLRQLKFASVDLELHTKYVPGGPESIYDVDQRVSVKTQV-IPPLPEdRFLCS-FSHIFAGGYAAGYYSYKWAEV 735
Cdd:PRK10280  542 FNKGYDMSELLSAALLDMRWHCLEENEAMQDVDDFELRALVAENLdLPAVPP-RYRSSyFAHIFGGGYAAGYYAYLWTQM 620
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063743433 736 LSADAFSAF-EDAGLddikaVKETGQRFRNTILALGGGKAPLKVFVEFRGREPSPEPLLRHNGL 798
Cdd:PRK10280  621 LADDGYQWFvEQGGL-----TRENGQRFREAILSRGNSTDLERLYRQWRGHAPQIMPMLQHRGL 679
M3A_MIP cd06457
Peptidase M3 mitochondrial intermediate peptidase (MIP); Peptidase M3 mitochondrial ...
214-790 1.37e-101

Peptidase M3 mitochondrial intermediate peptidase (MIP); Peptidase M3 mitochondrial intermediate peptidase (MIP; EC 3.4.24.59) belongs to the widespread subfamily M3A, that shows similarity to Thimet oligopeptidase (TOP). It is one of three peptidases responsible for the proteolytic processing of both nuclear and mitochondrial encoded precursor polypeptides targeted to various subcompartments of the mitochondria. It cleaves intermediate-size proteins initially processed by mitochondrial processing peptidase (MPP) to yield a processing intermediate with a typical N-terminal octapeptide that is sequentially cleaved by MIP to mature-size protein. MIP cleaves precursor proteins of respiratory components, including subunits of the electron transport chain and tri-carboxylic acid cycle enzymes, and components of the mitochondrial genetic machinery, including ribosomal proteins, translation factors, and proteins required for mitochondrial DNA metabolism. It has been suggested that the human MIP (HMIP polypeptide (gene symbol MIPEP) may be one of the loci predicted to influence the clinical manifestations of Friedreich's ataxia (FRDA), an autosomal recessive neurodegenerative disease caused by the lack of human frataxin. These proteins are enriched in cysteine residues, two of which are highly conserved, suggesting their importance to stability as well as in formation of metal binding sites, thus playing a role in MIP activity.


Pssm-ID: 341052 [Multi-domain]  Cd Length: 613  Bit Score: 326.82  E-value: 1.37e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 214 IYNAFKAIRESPD-WSSLSEARQRLVEAQIKEAVLIGIALDDEKREEFNKIEQELEKLSHKFSENVldatkkfeklitdk 292
Cdd:cd06457    98 LYDALKRVLEDPEiVASLTEEERRVAKLLLRDFEKSGIHLPEEKRKKFVELSSEILSLGREFLQNA-------------- 163
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 293 keieglppsalglfaqaavskghenataengpwiitldapsylpvmqHAKNRALREEVYRAYLSrassGDLDNTAIIDQI 372
Cdd:cd06457   164 -----------------------------------------------SAPDEEVRKKVYLAYHS----SSEEQEEVLEEL 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 373 LKLRLEKAKLLGYNNYAEVSMAMKMA-TVEKAAELLEKLRSASWDAAVQDMEDLKSFAKNQGAAESDSMTHWDTTFWSER 451
Cdd:cd06457   193 LKARAELAQLLGFPSYAHRALRDKMAkSPENVLSFLETLSDSLRPKAEKELEELRKLKRKHEGLSSPTLMPWDRDYYTGL 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 452 LRESKYDINEEELRPYFSLPKVMDGLFSLAKTLFGIDIEPADgLAP--VWNNDVRFYRVKDSSGNPIAYFYFDPYSRPSE 529
Cdd:cd06457   273 LRAQARSSDASELSPYFSLGTVMEGLSRLFSRLYGIRLVPVP-TQPgeVWHPDVRKLEVVHETEGLLGTIYCDLFERPGK 351
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 530 K--------RGGAWMDEVvsrsrvMAQKGSSVRLPVAHMVCNQTPPVGDKPSLMTFREVETVFHEFGHALQHMLTKQDEG 601
Cdd:cd06457   352 PpgaahftiRCSRRLDDD------DLGDGGSYQLPVVVLVCNFPPPSGSSPTLLSHSEVETLFHEMGHAMHSMLGRTRYQ 425
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 602 LVAGIRnIEWDAVELPSQFMENWCYHRDTLMSIAKHYETGETLPEEVYKKLLAARTFRAGSFSLRQLKFASVDLELHTKY 681
Cdd:cd06457   426 HVSGTR-CATDFVELPSILMEHFASDPRVLSLFARHYRTGEPLPEELLEKLCASKKLFSALETQQQILYALLDQVLHSED 504
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 682 VPGGPESIYDVDQRVSVKTQVIPPLPEDRFLCSFSHIFagGYAAGYYSYKWAEVLSADAFSA-FEDAGLDdikavKETGQ 760
Cdd:cd06457   505 PLDSSFDSTDILAELQNEYGLLPYVPGTAWQLRFGHLV--GYGATYYSYLFDRAIASKIWQKlFAKDPLS-----REAGE 577
                         570       580       590
                  ....*....|....*....|....*....|
gi 1063743433 761 RFRNTILALGGGKAPLKVFVEFRGREPSPE 790
Cdd:cd06457   578 RLREEVLKHGGGRDPWEMLADLLGEEELAE 607
TOP_N pfam19310
Neurolysin/Thimet oligopeptidase, N-terminal domain; Thimet oligopeptidase and neurolysin are ...
151-257 3.20e-69

Neurolysin/Thimet oligopeptidase, N-terminal domain; Thimet oligopeptidase and neurolysin are closely related zinc-dependent metallopeptidases that metabolize small bioactive peptides. They cleave many substrates at the same sites, but they recognize different positions on others. This entry represents the up-down alpha bundle domain found at the N terminus of these and related M3 peptidases.


Pssm-ID: 437142 [Multi-domain]  Cd Length: 123  Bit Score: 223.61  E-value: 3.20e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 151 KSVEPTWPKLVEPLEKIVDRLTVVWGMINHLKAVKDTPELRAAIEDVQPEKVKFQLRLGQSKPIYNAFKAIRESPDWSSL 230
Cdd:pfam19310  17 ANVEPTWSGLVEPLEKITDRLSWSWGIVNHLMGVKNSPELRAAYEEVQPEVVQFSNRLSQSKPIYNAFKALRESPDWDSL 96
                          90       100
                  ....*....|....*....|....*..
gi 1063743433 231 SEARQRLVEAQIKEAVLIGIALDDEKR 257
Cdd:pfam19310  97 EPAQKRIVEAAIRDAELSGVGLEGEKR 123
M3_like cd06258
M3-like Peptidases, zincin metallopeptidases, include M2_ACE, M3A, M3B_PepF, and M32 families; ...
342-795 2.24e-33

M3-like Peptidases, zincin metallopeptidases, include M2_ACE, M3A, M3B_PepF, and M32 families; The peptidase M3-like family, also called neurolysin-like family, is part of the "zincin" metallopeptidases, and includes the M2, M3 and M32 families of metallopeptidases. The M2 angiotensin converting enzyme (ACE, EC 3.4.15.1) is a membrane-bound, zinc-dependent dipeptidase that catalyzes the conversion of the decapeptide angiotensin I to the potent vasopressor octapeptide angiotensin II. The M3 family is subdivided into two subfamilies: the widespread M3A, which comprises a number of high-molecular mass endo- and exopeptidases from bacteria, archaea, protozoa, fungi, plants and animals, and the small M3B, whose members are enzymes primarily from bacteria. Well-known mammalian/eukaryotic M3A endopeptidases are the thimet oligopeptidase (TOP; endopeptidase 3.4.24.15), neurolysin (alias endopeptidase 3.4.24.16), and the mitochondrial intermediate peptidase. The first two are intracellular oligopeptidases, which act only on relatively short substrates of less than 20 amino acid residues, while the latter cleaves N-terminal octapeptides from proteins during their import into the mitochondria. The M3A subfamily also contains several bacterial endopeptidases, called oligopeptidases A, as well as a large number of bacterial carboxypeptidases, called dipeptidyl peptidases (Dcp; Dcp II; peptidyl dipeptidase; EC 3.4.15.5). M3B subfamily consists of oligopeptidase F (PepF) which hydrolyzes peptides containing 7-17 amino acid residues with fairly broad specificity. Peptidases in the M3 family contain the HEXXH motif that forms part of the active site in conjunction with a C-terminally-located Glutamic acid (Glu) residue. A single zinc ion is ligated by the side-chains of the two Histidine (His) residues, and the more C-terminal Glu. Most of the peptidases are synthesized without signal peptides or propeptides, and function intracellularly. There are similarities to the thermostable carboxypeptidases from Pyrococcus furiosus carboxypeptidase (PfuCP), and Thermus aquaticus (TaqCP), belonging to peptidase family M32. Little is known about function of this family, including carboxypeptidases Taq and Pfu.


Pssm-ID: 341049 [Multi-domain]  Cd Length: 473  Bit Score: 134.48  E-value: 2.24e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 342 KNRALREEVYRAY--LSRASSGDLDNTAIIDQILKLRLEKAKLLGYNNYAEVSMAMKMATVekaaelleklrsaSWDAAV 419
Cdd:cd06258    79 AAGAIPKELFKEYntLLSDFSKLWELRPLLEKLVELRNQAARLLGYEDPYDALLDLYEAGY-------------STEVVE 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 420 QDMEDLKSFAKnQGAAESDSMTHWDTTFWSERLRESKYDINEEELRPYFSLPKVMDGLFSLAKTLFGIdiepadglapvw 499
Cdd:cd06258   146 QDFEELKQAIP-LLYKELHAIQRPKLHRDYGFYYIPKFDVTSAMLKQKFDAEWMFEGALWFLQELGLE------------ 212
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 500 nndvrfyrvkdsSGNPIAYFYFDPYSrPSEKRGGAWMDEVVsrsrvmaqkgssvrLPVAHMVCNQTppvgdkpslMTFRE 579
Cdd:cd06258   213 ------------PGPLLTWERLDLYA-PLGKVCHAFATDFG--------------RKDVRITTNYT---------VTRDD 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 580 VETVFHEFGHALQHMLTKQDEglvAGIR-NIEWDAVELPSQFMENWCYHRDTLmsIAKHYETGETLPEEVYKKLLAARTF 658
Cdd:cd06258   257 ILTTHHEFGHALYELQYRTRF---AFLGnGASLGFHESQSQFLENSVGTFKHL--YSKHLLSGPQMDDESEEKFLLARLL 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 659 RAGSFSLRQLKFASVDLELHTkyvpgGPESIYDVDQRVSVKT----QVIPPLPEDR----FLCSFSHIFagGYAAGYYSY 730
Cdd:cd06258   332 DKVTFLPHIILVDKWEWAVFS-----GEIPKKPDLPSWWNLLykeyLGVPPVPRDEtytdGWAQFHHWA--GYDGYYIRY 404
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063743433 731 KWAEVLSADAF-SAFEDAG---LDDIKAVKETGQRFRNtILALGGGKAPLKVFVEFRGREPSPEPLLRH 795
Cdd:cd06258   405 ALGQVYAFQFYeKLCEDAGhegKCDIGNFDEAGQKLRE-ILRLGGSRPPTELLKNATGKEPNIASFLLH 472
M3B_PepF cd09606
Peptidase family M3B, oligopeptidase F (PepF); Peptidase family M3 oligopeptidase F ...
194-622 1.32e-08

Peptidase family M3B, oligopeptidase F (PepF); Peptidase family M3 oligopeptidase F (oligendopeptidase) is mostly bacterial and includes oligoendopeptidase F from Geobacillus stearothermophilus. This enzyme hydrolyzes peptides containing between 7 and 17 amino acids and may cleave proteins at Leu-Gly. The PepF gene is duplicated in Lactococcus lactis on the plasmid that bears it, while a shortened second copy is found in Bacillus subtilis. Most bacterial PepFs are cytoplasmic endopeptidases; however, the Bacillus amyloliquefaciens PepF oligopeptidase is a secreted protein and may facilitate the process of sporulation. Specifically, the yjbG gene encoding the homolog of the PepF1 and PepF2 oligoendopeptidases of Lactococcus lactis has been identified in Bacillus subtilis as an inhibitor of sporulation initiation when over-expressed from a multicopy plasmid.


Pssm-ID: 341069 [Multi-domain]  Cd Length: 543  Bit Score: 58.25  E-value: 1.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 194 IEDVQPEKVKFQLRLGQSKPIYNAFKAIRespDWSSLseaRQRLVEAQIKEAVLIGIALDDEKREEFNK----IEQELEK 269
Cdd:cd09606     3 WEELEPEFQELLERFINAKSAEELEAWLK---EISEL---RAEVEEMATLAYIRHTIDTDDEFYEAEQDffdeISPLLEE 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 270 LSHKFSENVLDA------TKKF----------------EKLITDKKEIeglppSALG-----LFAQAAVS-KGHEnatae 321
Cdd:cd09606    77 LEQELNKKLLASpfrkelEEEFgkqlfrlaenalklfsEENIPLLQEE-----NKLSseyqkLIASATIEfDGEE----- 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 322 ngpwiITLdaPSYLPVMQHaKNRALREEVYRAYLSR--ASSGDLDNtaIIDQILKLRLEKAKLLGYNNYAEVsMAMKMAT 399
Cdd:cd09606   147 -----LTL--SQLSPYLES-PDREVRKEAWEAIAEFflEHEEELDE--IYDELVKLRTQIAKNLGFENYREY-GYKRMGR 215
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 400 VEKAAELLEKLRsaswdAAVQdmED----LKSFAKNQGAA-ESDSMTHWDTTFwserlreskyDINEEELRPYfslpKVM 474
Cdd:cd09606   216 FDYTPEDVAKFR-----EAVE--KHvvplASKLREEQRKRlGLDKLRPYDEAV----------DFPGGNPKPF----GDA 274
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063743433 475 DGLFSLAKTLFG-IDIEPADglapvwnndvrFYRVKDSSGnpiayfYFDPYSRPSeKRGGAWMDEVvsrsrvmaqkgSSV 553
Cdd:cd09606   275 DELVEKAQKMYHeLSPETGE-----------FFDFMRENG------LLDLESRKG-KAPGGYCTYL-----------PEY 325
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063743433 554 RLPVAHMVCNQtppvgdkpslmTFREVETVFHEFGHALQHMLTKQDEglVAGIRNIEWDAVELPSQFME 622
Cdd:cd09606   326 KAPFIFANFNG-----------TSGDVDVLTHEAGHAFQAYLSRDLP--LPEYRWPTMEAAEIHSMSME 381
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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