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Conserved domains on  [gi|1063731309|ref|NP_001331464|]
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CTC-interacting domain 5 [Arabidopsis thaliana]

Protein Classification

CID family protein( domain architecture ID 10198918)

CTC-interacting domain (CID) family protein similar to Arabidopsis thaliana polyadenylate-binding protein-interacting protein 5/6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUE_CID7_like cd14371
CUE domain found in CTC-interacting domain proteins CID5, CID6, CID7 and similar proteins; ...
 68-110 2.26e-16

CUE domain found in CTC-interacting domain proteins CID5, CID6, CID7 and similar proteins; CID7 is encoded by ubiquitously expressed gene CID7. It contains an N-terminal PABC-interacting domain (PAM2 or PABP-interacting motif 2) which is also found in the human Paip1 and Paip2. At this point, it functions as an interaction partner of the PABC domain of Arabidopsis thaliana Poly(A)-binding proteins. It also harbors an ubiquitin-associated (UBA)-like CUE domain and a C-terminal small MutS-related (SMR) domain. CID5 and CID6 are encoded by gene CID5, CID6, respectively. CID5 is only expressed in immature siliques. The biological function of CID5 and CID6 remain unclear.


:

Pssm-ID: 270554  Cd Length: 43  Bit Score: 68.44  E-value: 2.26e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1063731309  68 DMDIEYLLVTFSGLSQESITDVYLANGGDLEATIEMLNQLEIY 110
Cdd:cd14371     1 LADVELLSSMFPGVSADSIAEVYEANGGDLDLTIDMLTQLESQ 43
 
Name Accession Description Interval E-value
CUE_CID7_like cd14371
CUE domain found in CTC-interacting domain proteins CID5, CID6, CID7 and similar proteins; ...
 68-110 2.26e-16

CUE domain found in CTC-interacting domain proteins CID5, CID6, CID7 and similar proteins; CID7 is encoded by ubiquitously expressed gene CID7. It contains an N-terminal PABC-interacting domain (PAM2 or PABP-interacting motif 2) which is also found in the human Paip1 and Paip2. At this point, it functions as an interaction partner of the PABC domain of Arabidopsis thaliana Poly(A)-binding proteins. It also harbors an ubiquitin-associated (UBA)-like CUE domain and a C-terminal small MutS-related (SMR) domain. CID5 and CID6 are encoded by gene CID5, CID6, respectively. CID5 is only expressed in immature siliques. The biological function of CID5 and CID6 remain unclear.


Pssm-ID: 270554  Cd Length: 43  Bit Score: 68.44  E-value: 2.26e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1063731309  68 DMDIEYLLVTFSGLSQESITDVYLANGGDLEATIEMLNQLEIY 110
Cdd:cd14371     1 LADVELLSSMFPGVSADSIAEVYEANGGDLDLTIDMLTQLESQ 43
 
Name Accession Description Interval E-value
CUE_CID7_like cd14371
CUE domain found in CTC-interacting domain proteins CID5, CID6, CID7 and similar proteins; ...
 68-110 2.26e-16

CUE domain found in CTC-interacting domain proteins CID5, CID6, CID7 and similar proteins; CID7 is encoded by ubiquitously expressed gene CID7. It contains an N-terminal PABC-interacting domain (PAM2 or PABP-interacting motif 2) which is also found in the human Paip1 and Paip2. At this point, it functions as an interaction partner of the PABC domain of Arabidopsis thaliana Poly(A)-binding proteins. It also harbors an ubiquitin-associated (UBA)-like CUE domain and a C-terminal small MutS-related (SMR) domain. CID5 and CID6 are encoded by gene CID5, CID6, respectively. CID5 is only expressed in immature siliques. The biological function of CID5 and CID6 remain unclear.


Pssm-ID: 270554  Cd Length: 43  Bit Score: 68.44  E-value: 2.26e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1063731309  68 DMDIEYLLVTFSGLSQESITDVYLANGGDLEATIEMLNQLEIY 110
Cdd:cd14371     1 LADVELLSSMFPGVSADSIAEVYEANGGDLDLTIDMLTQLESQ 43
CUE cd14279
CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ...
 68-104 5.62e-04

CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domain containing proteins that are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. CUE domains form three-helix bundle structures and are distantly related to the ubiquitin-associated (UBA) domains which are widely occurring ubiquitin-binding motifs found in a broad range of cellular proteins in species ranging from yeast to human. The majority of family members contain one CUE domain, but some family members from fungi harbor two CUE domains.


Pssm-ID: 270465  Cd Length: 38  Bit Score: 35.91  E-value: 5.62e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1063731309  68 DMDIEYLLVTFSGLSQESITDVYLANGGDLEATIEML 104
Cdd:cd14279     1 DEKLEQLQEMFPDLDEEVLEDVLEANNGDVEAAIDAL 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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