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Conserved domains on  [gi|1063730188|ref|NP_001330996|]
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myb domain protein 33 [Arabidopsis thaliana]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 999994)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03091 super family cl33633
hypothetical protein; Provisional
 32-137 1.22e-45

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03091:

Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 166.31  E-value: 1.22e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730188  32 LKKGPWSSAEDDILIDYVNKHGEGNWNAVQKHTSLFRCGKSCRLRWANHLRPNLKKGAFSQEEEQLIVELHAKMGNRWAR 111
Cdd:PLN03091   12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWSQ 91

                          90       100
                  ....*....|....*....|....*...
gi 1063730188 112 MAAHLPGRTDNEIKNYWNTRIKR--RQR 137
Cdd:PLN03091   92 IAAQLPGRTDNEIKNLWNSCLKKklRQR 119
 
Name Accession Description Interval E-value
PLN03091 PLN03091
hypothetical protein; Provisional
 32-137 1.22e-45

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 166.31  E-value: 1.22e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730188  32 LKKGPWSSAEDDILIDYVNKHGEGNWNAVQKHTSLFRCGKSCRLRWANHLRPNLKKGAFSQEEEQLIVELHAKMGNRWAR 111
Cdd:PLN03091   12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWSQ 91

                          90       100
                  ....*....|....*....|....*...
gi 1063730188 112 MAAHLPGRTDNEIKNYWNTRIKR--RQR 137
Cdd:PLN03091   92 IAAQLPGRTDNEIKNLWNSCLKKklRQR 119
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 87-130 4.93e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 74.85  E-value: 4.93e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1063730188  87 KGAFSQEEEQLIVELHAKMGNRWARMAAHLPGRTDNEIKNYWNT 130
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 32-135 1.73e-16

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 82.14  E-value: 1.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730188  32 LKKGPWSSAEDDILIDYVNKHGEGNWNAVqkhTSLF--RCGKSCRLRWANHLRPNLKKGAFSQEEEQLIVELHAKMGNRW 109
Cdd:COG5147    18 RKGGSWKRTEDEDLKALVKKLGPNNWSKV---ASLLisSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQW 94

                          90       100
                  ....*....|....*....|....*.
gi 1063730188 110 ARMAAHLPGRTDNEIKNYWNTRIKRR 135
Cdd:COG5147    95 STIADYKDRRTAQQCVERYVNTLEDL 120
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
87-134 1.39e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 64.94  E-value: 1.39e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1063730188   87 KGAFSQEEEQLIVELHAKMG-NRWARMAAHLPGRTDNEIKNYWNTRIKR 134
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 89-130 1.61e-12

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 61.82  E-value: 1.61e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1063730188  89 AFSQEEEQLIVELHAKMG-NRWARMAAHLPGRTDNEIKNYWNT 130
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRN 43
 
Name Accession Description Interval E-value
PLN03091 PLN03091
hypothetical protein; Provisional
 32-137 1.22e-45

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 166.31  E-value: 1.22e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730188  32 LKKGPWSSAEDDILIDYVNKHGEGNWNAVQKHTSLFRCGKSCRLRWANHLRPNLKKGAFSQEEEQLIVELHAKMGNRWAR 111
Cdd:PLN03091   12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWSQ 91

                          90       100
                  ....*....|....*....|....*...
gi 1063730188 112 MAAHLPGRTDNEIKNYWNTRIKR--RQR 137
Cdd:PLN03091   92 IAAQLPGRTDNEIKNLWNSCLKKklRQR 119
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 31-135 2.22e-40

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 146.38  E-value: 2.22e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730188  31 ALKKGPWSSAEDDILIDYVNKHGEGNWNAVQKHTSLFRCGKSCRLRWANHLRPNLKKGAFSQEEEQLIVELHAKMGNRWA 110
Cdd:PLN03212   22 GMKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWS 101

                          90       100
                  ....*....|....*....|....*
gi 1063730188 111 RMAAHLPGRTDNEIKNYWNTRIKRR 135
Cdd:PLN03212  102 LIAGRIPGRTDNEIKNYWNTHLRKK 126
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 87-130 4.93e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 74.85  E-value: 4.93e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1063730188  87 KGAFSQEEEQLIVELHAKMGNRWARMAAHLPGRTDNEIKNYWNT 130
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 32-135 1.73e-16

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 82.14  E-value: 1.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730188  32 LKKGPWSSAEDDILIDYVNKHGEGNWNAVqkhTSLF--RCGKSCRLRWANHLRPNLKKGAFSQEEEQLIVELHAKMGNRW 109
Cdd:COG5147    18 RKGGSWKRTEDEDLKALVKKLGPNNWSKV---ASLLisSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQW 94

                          90       100
                  ....*....|....*....|....*.
gi 1063730188 110 ARMAAHLPGRTDNEIKNYWNTRIKRR 135
Cdd:COG5147    95 STIADYKDRRTAQQCVERYVNTLEDL 120
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
87-134 1.39e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 64.94  E-value: 1.39e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1063730188   87 KGAFSQEEEQLIVELHAKMG-NRWARMAAHLPGRTDNEIKNYWNTRIKR 134
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 37-96 2.14e-13

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 64.64  E-value: 2.14e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063730188  37 WSSAEDDILIDYVNKHGeGNWNAVQKHTSlFRCGKSCRLRWANHLRPNLKKGAFSQEEEQ 96
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELG-RRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 89-130 1.61e-12

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 61.82  E-value: 1.61e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1063730188  89 AFSQEEEQLIVELHAKMG-NRWARMAAHLPGRTDNEIKNYWNT 130
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRN 43
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 34-81 3.56e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 60.98  E-value: 3.56e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1063730188  34 KGPWSSAEDDILIDYVNKHGeGNWNAVQKHTSLfRCGKSCRLRWANHL 81
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPG-RTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
34-83 8.15e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 59.93  E-value: 8.15e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1063730188   34 KGPWSSAEDDILIDYVNKHGEGNWNAVQKHtSLFRCGKSCRLRWANHLRP 83
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKE-LPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 36-81 8.26e-11

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 56.81  E-value: 8.26e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1063730188  36 PWSSAEDDILIDYVNKHGEGNWNAVQKHTsLFRCGKSCRLRWANHL 81
Cdd:cd00167     1 PWTEEEDELLLEAVKKYGKNNWEKIAKEL-PGRTPKQCRERWRNLL 45
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 36-63 2.55e-06

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 44.48  E-value: 2.55e-06
                          10        20
                  ....*....|....*....|....*...
gi 1063730188  36 PWSSAEDDILIDYVNKHGEGNWNAVQKH 63
Cdd:cd11660     2 KWTDEEDEALVEGVEKYGVGNWAKILKD 29
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 90-133 8.53e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 43.45  E-value: 8.53e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1063730188  90 FSQEEEQLIVELHAKMGNRWARMAAHLPGRTDNEIKNYWNTRIK 133
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLN 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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