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Conserved domains on  [gi|1063736204|ref|NP_001330386|]
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NPR1-like protein 3 [Arabidopsis thaliana]

Protein Classification

BTB/POZ domain and ankyrin repeat-containing protein( domain architecture ID 19105126)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) and ANK (ankyrin repeat) domain-containing protein similar to Arabidopsis thaliana regulatory protein NPR1-like protein 3

Gene Ontology:  GO:0005515

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
42-185 4.68e-80

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 246.45  E-value: 4.68e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  42 TKLSSNLEQLLSNSDCDYSDAEIIVD-GVPVGVHRCILAARSKFFQDLFKKEKKISKTEKPKYQLREMLPYGAVAHEAFL 120
Cdd:cd18310     1 KKLSSDLENLLDSPDLFYSDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLELRELIPGGIVGYDAFM 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063736204 121 YFLSYIYTGRLKPFPLEVSTCVDPVCSHDCCRPAIDFVVQLMYASSVLQVPELVSSFQRRLCNFV 185
Cdd:cd18310    81 LVLSYLYSGRLRLVPKEGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQRRLLDFV 145
NPR1_like_C super family cl13712
NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. ...
366-495 3.10e-70

NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. Proteins in this family are typically between 251 and 588 amino acids in length. The family is found in association with pfam00023, pfam00651. There are two conserved sequence motifs: LENRV and DLN. NPR1 (NIM1) is a defence protein in many plant species.


The actual alignment was detected with superfamily member pfam12313:

Pssm-ID: 372037  Cd Length: 204  Bit Score: 223.31  E-value: 3.10e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204 366 RRLTNPKDYHTKTAKGRESSKARLCIDILEREIRKNPMVLDTPMCSISMPEDLQMRLLYLEKRVGLAQLFFPTEAKVAMD 445
Cdd:pfam12313   1 KRLTRAKDYNTSTEQGKESPKDRLCIEILEQEERRNPLPGEASVSLAMAADDLRMRLLYLENRVALARLLFPAEAKVAMD 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063736204 446 IGNVEGTSEFTGLS-PPSSGLTGNLSQVDLNETPHMQTQRLLTRMVALMKT 495
Cdd:pfam12313  81 IAQVDGTSEFTGSSsSPSKGTGGKRTAVDLNETPFKQKEEHLSRMRALSKT 131
DUF3420 pfam11900
Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. ...
220-267 1.09e-12

Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with pfam00023.


:

Pssm-ID: 314729  Cd Length: 47  Bit Score: 62.43  E-value: 1.09e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1063736204 220 DLYRFCIEKEVPPEVAEKIKQLRLISPQDeETSPKISEKLLERIGKIL 267
Cdd:pfam11900   1 DLDNFCLEKELPPEVLAKIKELRLKSSLP-SLSPELDDLLEKRVRRIL 47
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
269-367 4.02e-11

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.82  E-value: 4.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204 269 ALDSDDVELVKLLLTE-SDITLDQANG---LHYSVVYSDPKVVaEILaLDMG-DVNYRNSRGYTVLHFAAMRREPSIIIS 343
Cdd:COG0666   127 AAYNGNLEIVKLLLEAgADVNAQDNDGntpLHLAAANGNLEIV-KLL-LEAGaDVNARDNDGETPLHLAAENGHLEIVKL 204
                          90       100
                  ....*....|....*....|....
gi 1063736204 344 LIDKGANASEFTSDGRSAVNILRR 367
Cdd:COG0666   205 LLEAGADVNAKDNDGKTALDLAAE 228
 
Name Accession Description Interval E-value
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
42-185 4.68e-80

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 246.45  E-value: 4.68e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  42 TKLSSNLEQLLSNSDCDYSDAEIIVD-GVPVGVHRCILAARSKFFQDLFKKEKKISKTEKPKYQLREMLPYGAVAHEAFL 120
Cdd:cd18310     1 KKLSSDLENLLDSPDLFYSDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLELRELIPGGIVGYDAFM 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063736204 121 YFLSYIYTGRLKPFPLEVSTCVDPVCSHDCCRPAIDFVVQLMYASSVLQVPELVSSFQRRLCNFV 185
Cdd:cd18310    81 LVLSYLYSGRLRLVPKEGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQRRLLDFV 145
NPR1_like_C pfam12313
NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. ...
366-495 3.10e-70

NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. Proteins in this family are typically between 251 and 588 amino acids in length. The family is found in association with pfam00023, pfam00651. There are two conserved sequence motifs: LENRV and DLN. NPR1 (NIM1) is a defence protein in many plant species.


Pssm-ID: 372037  Cd Length: 204  Bit Score: 223.31  E-value: 3.10e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204 366 RRLTNPKDYHTKTAKGRESSKARLCIDILEREIRKNPMVLDTPMCSISMPEDLQMRLLYLEKRVGLAQLFFPTEAKVAMD 445
Cdd:pfam12313   1 KRLTRAKDYNTSTEQGKESPKDRLCIEILEQEERRNPLPGEASVSLAMAADDLRMRLLYLENRVALARLLFPAEAKVAMD 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063736204 446 IGNVEGTSEFTGLS-PPSSGLTGNLSQVDLNETPHMQTQRLLTRMVALMKT 495
Cdd:pfam12313  81 IAQVDGTSEFTGSSsSPSKGTGGKRTAVDLNETPFKQKEEHLSRMRALSKT 131
DUF3420 pfam11900
Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. ...
220-267 1.09e-12

Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with pfam00023.


Pssm-ID: 314729  Cd Length: 47  Bit Score: 62.43  E-value: 1.09e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1063736204 220 DLYRFCIEKEVPPEVAEKIKQLRLISPQDeETSPKISEKLLERIGKIL 267
Cdd:pfam11900   1 DLDNFCLEKELPPEVLAKIKELRLKSSLP-SLSPELDDLLEKRVRRIL 47
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
269-367 4.02e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.82  E-value: 4.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204 269 ALDSDDVELVKLLLTE-SDITLDQANG---LHYSVVYSDPKVVaEILaLDMG-DVNYRNSRGYTVLHFAAMRREPSIIIS 343
Cdd:COG0666   127 AAYNGNLEIVKLLLEAgADVNAQDNDGntpLHLAAANGNLEIV-KLL-LEAGaDVNARDNDGETPLHLAAENGHLEIVKL 204
                          90       100
                  ....*....|....*....|....
gi 1063736204 344 LIDKGANASEFTSDGRSAVNILRR 367
Cdd:COG0666   205 LLEAGADVNAKDNDGKTALDLAAE 228
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
61-184 1.41e-10

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 58.09  E-value: 1.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204   61 DAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKISKteKPKYQLREmlpygaVAHEAFLYFLSYIYTGRLKPFPlevst 140
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESD--KSEIYLDD------VSPEDFRALLNFLYTGKLDLPE----- 67
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1063736204  141 cvdpvcshdccrpaiDFVVQLMYASSVLQVPELVSSFQRRLCNF 184
Cdd:smart00225  68 ---------------ENVEELLELADYLQIPGLVELCEEFLLKL 96
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
48-174 6.26e-10

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 56.50  E-value: 6.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  48 LEQLLSNsdCDYSDAEIIVDGVPVGVHRCILAARSKFFQDLFkkEKKISKTEKPKYQLREMLPygavahEAFLYFLSYIY 127
Cdd:pfam00651   1 LNELREQ--GELCDVTLVVGDKEFRAHKAVLAACSPYFKALF--SGQESESSVSEITLDDVSP------EDFEALLEFMY 70
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1063736204 128 TGRLKPfplevstcvdpvcshdccrpaIDFVVQLMYASSVLQVPELV 174
Cdd:pfam00651  71 TGKLIS---------------------EENVDDLLAAADKLQIPSLV 96
Ank_2 pfam12796
Ankyrin repeats (3 copies);
269-350 3.32e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.49  E-value: 3.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204 269 ALDSDDVELVKLLLTE-SDITLDQANG---LHYSVVYSDPKVVaEILaLDMGDVNYRNSrGYTVLHFAAMRREPSIIISL 344
Cdd:pfam12796   4 AAKNGNLELVKLLLENgADANLQDKNGrtaLHLAAKNGHLEIV-KLL-LEHADVNLKDN-GRTALHYAARSGHLEIVKLL 80

                  ....*.
gi 1063736204 345 IDKGAN 350
Cdd:pfam12796  81 LEKGAD 86
PHA03100 PHA03100
ankyrin repeat protein; Provisional
252-364 5.52e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 42.34  E-value: 5.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204 252 SPKISEKLLERiGKILKALDSDDVELVKLLLTESDITLDQANGLHYSVVYSDPKVVAEILaLDMG-DVNYRNSRGYTVLH 330
Cdd:PHA03100  120 SYSIVEYLLDN-GANVNIKNSDGENLLHLYLESNKIDLKILKLLIDKGVDINAKNRVNYL-LSYGvPINIKDVYGFTPLH 197
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1063736204 331 FAAMRREPSIIISLIDKGANASEFTSDGRSAVNI 364
Cdd:PHA03100  198 YAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHI 231
 
Name Accession Description Interval E-value
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
42-185 4.68e-80

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 246.45  E-value: 4.68e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  42 TKLSSNLEQLLSNSDCDYSDAEIIVD-GVPVGVHRCILAARSKFFQDLFKKEKKISKTEKPKYQLREMLPYGAVAHEAFL 120
Cdd:cd18310     1 KKLSSDLENLLDSPDLFYSDAEIIVEgGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPKLELRELIPGGIVGYDAFM 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063736204 121 YFLSYIYTGRLKPFPLEVSTCVDPVCSHDCCRPAIDFVVQLMYASSVLQVPELVSSFQRRLCNFV 185
Cdd:cd18310    81 LVLSYLYSGRLRLVPKEGSACVDSDCWHVACRPAVDFALEVLYAASVFQIPELVSLFQRRLLDFV 145
NPR1_like_C pfam12313
NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. ...
366-495 3.10e-70

NPR1/NIM1 like defence protein C terminal; This family of proteins is found in eukaryotes. Proteins in this family are typically between 251 and 588 amino acids in length. The family is found in association with pfam00023, pfam00651. There are two conserved sequence motifs: LENRV and DLN. NPR1 (NIM1) is a defence protein in many plant species.


Pssm-ID: 372037  Cd Length: 204  Bit Score: 223.31  E-value: 3.10e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204 366 RRLTNPKDYHTKTAKGRESSKARLCIDILEREIRKNPMVLDTPMCSISMPEDLQMRLLYLEKRVGLAQLFFPTEAKVAMD 445
Cdd:pfam12313   1 KRLTRAKDYNTSTEQGKESPKDRLCIEILEQEERRNPLPGEASVSLAMAADDLRMRLLYLENRVALARLLFPAEAKVAMD 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063736204 446 IGNVEGTSEFTGLS-PPSSGLTGNLSQVDLNETPHMQTQRLLTRMVALMKT 495
Cdd:pfam12313  81 IAQVDGTSEFTGSSsSPSKGTGGKRTAVDLNETPFKQKEEHLSRMRALSKT 131
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-132 2.33e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 65.27  E-value: 2.33e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063736204  59 YSDAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKISKTEkpKYQLREmlpygaVAHEAFLYFLSYIYTGRLK 132
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSS--EIELDD------VSPEAFEALLDYIYTGELE 66
DUF3420 pfam11900
Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. ...
220-267 1.09e-12

Domain of unknown function (DUF3420); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with pfam00023.


Pssm-ID: 314729  Cd Length: 47  Bit Score: 62.43  E-value: 1.09e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1063736204 220 DLYRFCIEKEVPPEVAEKIKQLRLISPQDeETSPKISEKLLERIGKIL 267
Cdd:pfam11900   1 DLDNFCLEKELPPEVLAKIKELRLKSSLP-SLSPELDDLLEKRVRRIL 47
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
44-132 3.08e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 60.71  E-value: 3.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  44 LSSNLEQLLSNSDcdYSDAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKISKTEkpKYQLREmlpygaVAHEAFLYFL 123
Cdd:cd18287     9 LSEDIGALFLNEE--YSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQS--EIELKD------TNAEAFKALL 78

                  ....*....
gi 1063736204 124 SYIYTGRLK 132
Cdd:cd18287    79 KYIYTGRLT 87
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
269-367 4.02e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.82  E-value: 4.02e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204 269 ALDSDDVELVKLLLTE-SDITLDQANG---LHYSVVYSDPKVVaEILaLDMG-DVNYRNSRGYTVLHFAAMRREPSIIIS 343
Cdd:COG0666   127 AAYNGNLEIVKLLLEAgADVNAQDNDGntpLHLAAANGNLEIV-KLL-LEAGaDVNARDNDGETPLHLAAENGHLEIVKL 204
                          90       100
                  ....*....|....*....|....
gi 1063736204 344 LIDKGANASEFTSDGRSAVNILRR 367
Cdd:COG0666   205 LLEAGADVNAKDNDGKTALDLAAE 228
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
61-184 1.41e-10

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 58.09  E-value: 1.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204   61 DAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKISKteKPKYQLREmlpygaVAHEAFLYFLSYIYTGRLKPFPlevst 140
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESD--KSEIYLDD------VSPEDFRALLNFLYTGKLDLPE----- 67
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1063736204  141 cvdpvcshdccrpaiDFVVQLMYASSVLQVPELVSSFQRRLCNF 184
Cdd:smart00225  68 ---------------ENVEELLELADYLQIPGLVELCEEFLLKL 96
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
59-131 3.62e-10

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 57.64  E-value: 3.62e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063736204  59 YSDAEIIVDGVPVGVHRCILAARSKFFQDLFK---KEKKISKTEKPKyqlremlpygaVAHEAFLYFLSYIYTGRL 131
Cdd:cd18295    19 YSDVTFNVHGESFPAHRCILSARSPYFAEMFEtkwKDKREINLKHPL-----------VNPDAFRALLQYLYTGRL 83
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
48-174 6.26e-10

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 56.50  E-value: 6.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  48 LEQLLSNsdCDYSDAEIIVDGVPVGVHRCILAARSKFFQDLFkkEKKISKTEKPKYQLREMLPygavahEAFLYFLSYIY 127
Cdd:pfam00651   1 LNELREQ--GELCDVTLVVGDKEFRAHKAVLAACSPYFKALF--SGQESESSVSEITLDDVSP------EDFEALLEFMY 70
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1063736204 128 TGRLKPfplevstcvdpvcshdccrpaIDFVVQLMYASSVLQVPELV 174
Cdd:pfam00651  71 TGKLIS---------------------EENVDDLLAAADKLQIPSLV 96
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
42-129 1.10e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 56.24  E-value: 1.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  42 TKLSSNLEQLLSNSDCDYSDAEIIVDGVPVGVHRCILAARSKFFQDLFKkeKKISKTEKPKYQLREMLPygavAHEAFLY 121
Cdd:cd18309     3 TTLEQDMEAFLESVGGDFCDITLLLDGHPIPAHKAILAARCSYFEAMFR--SFMPEDNTVNISIGEMVP----SRQAFDS 76

                  ....*...
gi 1063736204 122 FLSYIYTG 129
Cdd:cd18309    77 LLRYIYYG 84
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
44-132 6.51e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 53.79  E-value: 6.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  44 LSSNLEQLLSNSDcdYSDAEIIV--DGVPVGVHRCILAARSKFFQDLFKKEKKISKTEKPkYQLREMLPygavahEAFLY 121
Cdd:cd18294     1 FAADMKSLINNPE--FSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSP-LVLSDIEP------EVFRA 71
                          90
                  ....*....|.
gi 1063736204 122 FLSYIYTGRLK 132
Cdd:cd18294    72 VLEFIYTNCVT 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
235-361 5.02e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.57  E-value: 5.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204 235 AEKIKQLRLISPQDEETSPKISEKLLERIGKILKALDSDDVELVKLLLTESDITLDQANG---LHYSVVYSDPKVVAEIL 311
Cdd:COG0666    28 AALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGntlLHAAARNGDLEIVKLLL 107
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1063736204 312 ALDMgDVNYRNSRGYTVLHFAAMRREPSIIISLIDKGANASEFTSDGRSA 361
Cdd:COG0666   108 EAGA-DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTP 156
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
46-131 7.75e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 50.29  E-value: 7.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  46 SNLEQLLSnsDCDYSDAEIIVD-GVPVGVHRCILAARSKFFQDLFKKEKKISKTEkpkyqlremlpygAVAHEAFLYFLS 124
Cdd:cd18299     1 EDLRNLLH--SPSCADVVFILQgGVRIFAHRIVLAAASSVFADLFLMMTVVTLDS-------------DITPEAFRRVLE 65

                  ....*..
gi 1063736204 125 YIYTGRL 131
Cdd:cd18299    66 FLYTGVL 72
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
49-131 1.13e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 50.42  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  49 EQLLSNSDCDYSdaeIIVDGVPVGVHRCILAARSKFFQDLFKKEKKISkTEKPkyqlremlpyGAVAHEAFLYFLSYIYT 128
Cdd:cd18290    20 EQRLQGLYCDVS---VVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAV-VELP----------AAVQPQSFQQILSFCYT 85

                  ...
gi 1063736204 129 GRL 131
Cdd:cd18290    86 GRL 88
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
44-129 1.89e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 49.21  E-value: 1.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  44 LSSNLEQLLSNSDC--DYSDAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKIS-KTEKPKYQLREMLPygavaHEAFL 120
Cdd:cd18301     1 FQEDFKKLLDEADEgdNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSeDAVGCDVVHIEKVP-----PEIFE 75

                  ....*....
gi 1063736204 121 YFLSYIYTG 129
Cdd:cd18301    76 QLLQFIYTD 84
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-131 3.43e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 49.26  E-value: 3.43e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063736204  59 YSDAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKiSKTEKPkyqlremlpyGAVAHEAFLYFLSYIYTGRL 131
Cdd:cd18289    29 YCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSK-SAFELP----------ATVPPACFQQILSFCYTGKL 90
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
269-389 1.03e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 50.34  E-value: 1.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204 269 ALDSDDVELVKLLLtESDITLDQANG-----LHYSVVYSDPKVVaEILaLDMG-DVNYRNSRGYTVLHFAAMRREPSIII 342
Cdd:COG0666   160 AAANGNLEIVKLLL-EAGADVNARDNdgetpLHLAAENGHLEIV-KLL-LEAGaDVNAKDNDGKTALDLAAENGNLEIVK 236
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1063736204 343 SLIDKGANASEFTSDGRSAVNILRRLTNPKDYHTKTAKGRESSKARL 389
Cdd:COG0666   237 LLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
43-130 2.76e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 46.37  E-value: 2.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  43 KLSSNLEQLLSNSDcdYSDAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKISKteKPKYQLREmlpygaVAHEAFLYF 122
Cdd:cd18279     4 RLAEDLGNLWENSR--FTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESK--KNRVEIND------VDPEVFKEM 73

                  ....*...
gi 1063736204 123 LSYIYTGR 130
Cdd:cd18279    74 MRFIYTGK 81
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
43-174 3.22e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 46.24  E-value: 3.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  43 KLSSNLEQLlsNSDCDYSDAEIIVDGVPVGVHRCILAARSKFFQDLFKKEkkISKTEKPKYQLREMLPygavahEAFLYF 122
Cdd:cd18256     6 LILAQLNKL--RGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGG--MSESSKDVVQIHGVEP------DIFHIL 75
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063736204 123 LSYIYTGRlkpfpLEVSTcvdpvcshdccrpaiDFVVQLMYASSVLQVPELV 174
Cdd:cd18256    76 LDFIYTGV-----VEVTV---------------SNVQELLVAADMLQLTEVV 107
Ank_2 pfam12796
Ankyrin repeats (3 copies);
269-350 3.32e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.49  E-value: 3.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204 269 ALDSDDVELVKLLLTE-SDITLDQANG---LHYSVVYSDPKVVaEILaLDMGDVNYRNSrGYTVLHFAAMRREPSIIISL 344
Cdd:pfam12796   4 AAKNGNLELVKLLLENgADANLQDKNGrtaLHLAAKNGHLEIV-KLL-LEHADVNLKDN-GRTALHYAARSGHLEIVKLL 80

                  ....*.
gi 1063736204 345 IDKGAN 350
Cdd:pfam12796  81 LEKGAD 86
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
43-130 6.02e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 45.77  E-value: 6.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  43 KLSSNLEQLLSNSDcdYSDAEIIVDGVPVGVHRCILAARSKFFQDLFkkEKKISKTEKPKYQLREMLPygavahEAFLYF 122
Cdd:cd18343     7 RLAEDLGNLWENSR--FTDCSLFVGGQEFKAHKSILAARSPVFNAMF--EHEMEESKKNRVEINDVDP------EVFKEM 76

                  ....*...
gi 1063736204 123 LSYIYTGR 130
Cdd:cd18343    77 MRFIYTGK 84
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
43-130 1.37e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 44.45  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  43 KLSSNLEQLLSNSDcdYSDAEIIVDGVPVGVHRCILAARSKFFQDLFK---KEKKISKTEkpkyqlremlpYGAVAHEAF 119
Cdd:cd18345     4 RLSDDLGLLFERSA--FSDVTLCVGGREFQAHKAILAARSPVFNAMFEhemEERKQNRVE-----------ITDVDHEVM 70
                          90
                  ....*....|.
gi 1063736204 120 LYFLSYIYTGR 130
Cdd:cd18345    71 REMLRFIYTGK 81
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
43-129 1.70e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 44.17  E-value: 1.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  43 KLSSNLEQLLSNSDCdySDAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKISKTEKPKYQlremlpygAVAHEAFLYF 122
Cdd:cd18286     3 RLGKDLLQLFLNGED--SDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLT--------GVSHAAVSFV 72

                  ....*..
gi 1063736204 123 LSYIYTG 129
Cdd:cd18286    73 LLFIYGG 79
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
60-161 8.00e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 41.55  E-value: 8.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  60 SDAEIIVDGVPVGVHRCILAARSKFFQDLFkkekkiskTEKPKY--QLREMLPYGAVAHEAFLYFLSYIYTGRLkpfple 137
Cdd:cd18283     3 TDVDLVFQGTCFPVHRAILSARCPFFRDLL--------SSSPGYgaEIPVDLPTAGIDVPMFSALLRYLYTGEF------ 68
                          90       100
                  ....*....|....*....|....
gi 1063736204 138 vstcvdpvCSHDCCRPAIDFVVQL 161
Cdd:cd18283    69 --------GSEDSRSQNLDVLIQL 84
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
259-361 9.22e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 44.56  E-value: 9.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204 259 LLERIGKILKALDSDDVELVKLLLTESDITLDQANGLHYSVVYSDPKVVAEILALDMGDVNYRNSRGYTVLHFAAMRREP 338
Cdd:COG0666    21 LALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDL 100
                          90       100
                  ....*....|....*....|...
gi 1063736204 339 SIIISLIDKGANASEFTSDGRSA 361
Cdd:COG0666   101 EIVKLLLEAGADVNARDKDGETP 123
Ank_5 pfam13857
Ankyrin repeats (many copies);
310-364 1.06e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.02  E-value: 1.06e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063736204 310 ILALDMGDVNYRNSRGYTVLHFAAMRREPSIIISLIDKGANASEFTSDGRSAVNI 364
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
46-131 1.22e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 41.50  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  46 SNLEQLLSNSDcdYSDAEIIVDGVPVGVHRCILAARSKFFQDLFkKEKKISKTEKPKYQLREmlPYGAVAheAFLYFLSY 125
Cdd:cd18292     6 QDIAQLYNNEE--LSDIVLRVGGKVFHAHRLILAKSSDVFRVML-SNDWWSESKQSEIELVE--DPECAA--VFEKFLRY 78

                  ....*.
gi 1063736204 126 IYTGRL 131
Cdd:cd18292    79 LYTGQI 84
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
59-129 1.82e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 40.23  E-value: 1.82e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063736204  59 YSDAEIIVDGVPVGVHRCILAARSKFFQDLFkkeKKISKTEKPKYQLREmlpygaVAHEAFLYFLSYIYTG 129
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALL---KETPPDEHPVIILPD------VPYSELKALLDFIYTG 62
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
61-132 2.39e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 41.09  E-value: 2.39e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063736204  61 DAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKisKTEKPKYQLREMLPygavahEAFLYFLSYIYTGRLK 132
Cdd:cd18306    20 DVILQVGGHEIPAHRAVLACASPYLFELFSSDSD--GESILTVKLDGLDP------DAVEVLVNYAYTSRLE 83
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
41-175 3.62e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 40.30  E-value: 3.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  41 LTKLSSNL-EQLLSNSDCDYSdaeIIVDGVPVGVHRCILAARSKFFQDLFKkeKKISKTEKPKYQLREMlpygaVAHEAF 119
Cdd:cd18330     2 YTKLLGELnEQRKRDFFCDCS---IIVEGRIFKAHRNILFANSGYFRALLI--HYIQDSGRHSTASLDI-----VTSEAF 71
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063736204 120 LYFLSYIYTGRLKpfplevstcvdpVCSHDccrpaidfVVQLMYASSVLQVPELVS 175
Cdd:cd18330    72 SIILDFLYSGKLD------------LCSEN--------VIEVMSAASYLQMTDVVN 107
PHA03100 PHA03100
ankyrin repeat protein; Provisional
252-364 5.52e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 42.34  E-value: 5.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204 252 SPKISEKLLERiGKILKALDSDDVELVKLLLTESDITLDQANGLHYSVVYSDPKVVAEILaLDMG-DVNYRNSRGYTVLH 330
Cdd:PHA03100  120 SYSIVEYLLDN-GANVNIKNSDGENLLHLYLESNKIDLKILKLLIDKGVDINAKNRVNYL-LSYGvPINIKDVYGFTPLH 197
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1063736204 331 FAAMRREPSIIISLIDKGANASEFTSDGRSAVNI 364
Cdd:PHA03100  198 YAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHI 231
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-131 6.78e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 39.60  E-value: 6.78e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063736204  59 YSDAEIIVDGVPVGVHRCILAARSKFFQDLFKkekkiSKTEKPKYQLRemlpygAVAHEAFLYFLSYIYTGRL 131
Cdd:cd18221    18 FTDITLIVDGHQFKAHKAVLAACSQFFYKFFQ-----DFTQEPLVEIE------GVSNMAFRHLIEFTYTAKL 79
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
59-175 6.99e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 39.14  E-value: 6.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  59 YSDAEIIVDGVPVGVHRCILAARSKFFQDLFK---KEKKISKTEKPkyqlremlpygAVAHEAFLYFLSYIYTGRLKPFP 135
Cdd:cd18300     9 FSDVTFIVEDGTIPAHKALLVARCDVMAAMFGgnfRESSAKEVELP-----------GVSKETFLALLEYLYTDQAPILE 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1063736204 136 levstCVDPVCshdccrpaidfvvqLMYASSVLQVPELVS 175
Cdd:cd18300    78 -----DGDCVG--------------LIVLANRLCLPRLVA 98
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
74-178 8.45e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 39.13  E-value: 8.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  74 HRCILAARSKFFQDLFKKEKKISKTEkpkyqlremLPYGAVAHEAFLYFLSYIYTGRLKpfpleVSTCVdpvcshdccrp 153
Cdd:cd18231    31 HKGVLAAYSQFFHSLFTQNKQLQRVE---------LSLEALTSQGLQQILNFIYTSKLL-----VNSCN----------- 85
                          90       100
                  ....*....|....*....|....*
gi 1063736204 154 aidfVVQLMYASSVLQVPELVSSFQ 178
Cdd:cd18231    86 ----VQDVLNAAAVLQMNDIAASCQ 106
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-132 9.96e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 39.05  E-value: 9.96e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063736204  59 YSDAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKISKteKPKYQLREMLPygavahEAFLYFLSYIYTGRLK 132
Cdd:cd18253    18 FTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESR--EMLVEINGILA------EAMDCFLQYVYTGKVK 83
PHA03100 PHA03100
ankyrin repeat protein; Provisional
254-352 1.21e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.19  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204 254 KISEKLLERIGKIlKALDSddvelVKLLLT-ESDITLDQANG---LHYSVVYSDPKVVAeiLALDMG-DVNYRNSRGYTV 328
Cdd:PHA03100  157 KILKLLIDKGVDI-NAKNR-----VNYLLSyGVPINIKDVYGftpLHYAVYNNNPEFVK--YLLDLGaNPNLVNKYGDTP 228
                          90       100
                  ....*....|....*....|....
gi 1063736204 329 LHFAAMRREPSIIISLIDKGANAS 352
Cdd:PHA03100  229 LHIAILNNNKEIFKLLLNNGPSIK 252
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
49-131 1.35e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 38.48  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  49 EQLLSNSDCDYSdaeIIVDGVPVGVHRCILAARSKFFQDLFKKEKKISKTekpkyqlreMLPYGAVAHEAFLYFLSYIYT 128
Cdd:cd18204    11 EQRLEGEFCDIA---IVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSS---------VIEIDFLRSDIFEEVLNYMYT 78

                  ...
gi 1063736204 129 GRL 131
Cdd:cd18204    79 AKI 81
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
49-173 1.51e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 38.41  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  49 EQLLSNSDcdYSDAEIIVDGVPVGVHRCILAARSKFFQDLFKkeKKISKTEKPKYQLREMlPYgavahEAFLYFLSYIYT 128
Cdd:cd18297     4 PHYVNNPE--MSDVTFLVEGRPFYAHKIVLVTASDRFKSMLS--SGSTEAQTPVIEIPDI-RY-----DIFQLMMQYLYT 73
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1063736204 129 GrlkpfplEVSTCVDPVcshdccrpaiDFVVQLMYASSVLQVPEL 173
Cdd:cd18297    74 G-------GVESLDVAQ----------DDALELLRAASFFQLDGL 101
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
58-168 1.52e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 38.80  E-value: 1.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  58 DYSDAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKISKTEKpkyqlREMLPYGAVAHEAFLYFLSYIYTGRLKPFPLE 137
Cdd:cd18258    16 EFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGE-----KLELTMSNINADVLELLLEFVYTGSLIIDSAN 90
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1063736204 138 VSTCVDPVCS---HDCCRPAIDFVVQLMYASSVL 168
Cdd:cd18258    91 AKTLLEAANKfqfHTFCKVCVSFLEKQLTASNCL 124
Ank_2 pfam12796
Ankyrin repeats (3 copies);
295-361 1.83e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.79  E-value: 1.83e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063736204 295 LHYSVVYSDPKVVaEILALDMGDVNYRNSRGYTVLHFAAMRREPSIIISLIDKgaNASEFTSDGRSA 361
Cdd:pfam12796   1 LHLAAKNGNLELV-KLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH--ADVNLKDNGRTA 64
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
49-131 2.47e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 37.91  E-value: 2.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  49 EQLLSNSDCDYSdaeIIVDGVPVGVHRCILAARSKFFQDLFKKEKKISKTEKpkyqlreMLPYGAVAHEAFLYFLSYIYT 128
Cdd:cd18202    12 QQRLNNQFCDVT---LLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEA-------VVDLSGFCKSSFLPLLEFAYT 81

                  ...
gi 1063736204 129 GRL 131
Cdd:cd18202    82 SEL 84
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
56-129 2.74e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 37.62  E-value: 2.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063736204  56 DCDYSDAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKisktEKPKYQLrEMLPYGAVAHEAflyFLSYIYTG 129
Cdd:cd18298     9 DPRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWN----EDDKNVI-EIDQYSYPVYYA---FLRYLYTD 74
PHA03095 PHA03095
ankyrin-like protein; Provisional
317-367 2.89e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.01  E-value: 2.89e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063736204 317 DVNYRNSRGYTVLHFAAMRREPSIIISLIDKGANASEFTSDGRSAV-NILRR 367
Cdd:PHA03095  249 SINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLsLMVRN 300
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
59-132 2.99e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 37.32  E-value: 2.99e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063736204  59 YSDAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKISKTEKPKYQLREMLPygAVAHEaflyFLSYIYTGRLK 132
Cdd:cd18245    14 LCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIELEGISV--EVMEE----ILDYIYTGQIK 81
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
73-138 4.39e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 36.55  E-value: 4.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063736204  73 VHRCILAARSKFFQDLFKKEKKISktEKPKYQLREMLPygavahEAFLYFLSYIYTGRLKPFPLEV 138
Cdd:cd18314    20 AHRIVLCARSPVFRSMLTGSMIES--NLKEVTLEDVEP------EIFETVLKYMYTGQVTLSEENV 77
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
44-130 4.60e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 37.24  E-value: 4.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  44 LSSNLEQLLSNSDcdYSDAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKisKTEKPKYQLREMLPygavahEAFLYFL 123
Cdd:cd18344    10 LTDDLGELWENSL--FTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEME--ERLKNPIEIHDLDP------QVFKEMM 79

                  ....*..
gi 1063736204 124 SYIYTGR 130
Cdd:cd18344    80 GFIYTGK 86
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
61-181 5.28e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 37.19  E-value: 5.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  61 DAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKISktekpkyqlremLPYGAVAHEAFLYFLSYIYTGRLKpfplevst 140
Cdd:cd18333    23 DVIIVVQNALFRAHKNILAASSVYLKSLVVHDNLIN------------LDHEMVSPGIFRLILDYIYTGRLS-------- 82
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1063736204 141 cvdpvcshDCCRPAIDFVVQLMYASSVLQVPELVSSFQRRL 181
Cdd:cd18333    83 --------EGDPGSEQNLGAVLAAASYLQIPDLVALCKKKL 115
BTB1_POZ_LZTR1 cd18308
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
59-133 6.18e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349617 [Multi-domain]  Cd Length: 156  Bit Score: 37.36  E-value: 6.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  59 YSDAEIIV--DGVPVGVHRCILAARSKFFQDLF--KKEKKISKTEK---------------------PKYQLREMLPyga 113
Cdd:cd18308    23 FCDVEFIVgeEEERIPAHIAFVAARSKWLRNKIlqARERQKQKAEQevedegseadsssaskndspmLEVRLPEADP--- 99
                          90       100
                  ....*....|....*....|
gi 1063736204 114 vahEAFLYFLSYIYTGRLKP 133
Cdd:cd18308   100 ---EAFELILSFIYTDKIDP 116
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
55-131 7.61e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 36.67  E-value: 7.61e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063736204  55 SDCDYSDAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKISKTEKPKYQlremlpygAVAHEAFLYFLSYIYTGRL 131
Cdd:cd18250    17 AERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLH--------GVSAEILGLLLDFSYTGRV 85
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
67-175 7.78e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 36.69  E-value: 7.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  67 DGVPVGVHRCILAARSKFFQDLFKKEkkisktEKPKYQLReMLPYGAVAHEAFLYFLSYIYTGRLKPFPLEVstcvdpvc 146
Cdd:cd18293    23 EGESVPAHCCVLSACSPYLTERLSSE------PPPAGQKV-VLELQGLKAHTLLKLVDFLYTSELEVSSEEA-------- 87
                          90       100
                  ....*....|....*....|....*....
gi 1063736204 147 sHDccrpaidfvvqLMYASSVLQVPELVS 175
Cdd:cd18293    88 -QD-----------VLAAARRLQISELES 104
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
61-132 9.19e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 36.73  E-value: 9.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063736204  61 DAEIIVDGVPVGVHRCILAARSKFFQDLFkkEKKISKTEKPKYQLREMLPygavahEAFLYFLSYIYTGRLK 132
Cdd:cd18271    26 DFNIIVKDETIPCHRCVLAACSDFFRAMF--EVNMKERDDGSVTISNLSP------KAVKAFLDYAYTGKAE 89
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
43-130 9.20e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 36.62  E-value: 9.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063736204  43 KLSSNLEQLLSNSDcdYSDAEIIVDGVPVGVHRCILAARSKFFQDLFKKEKKISKteKPKYQLREMLPygavahEAFLYF 122
Cdd:cd18342     8 RLADELGGLWENSR--FTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESK--KNRVEINDVEP------EVFKEM 77

                  ....*...
gi 1063736204 123 LSYIYTGR 130
Cdd:cd18342    78 MCFIYTGK 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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