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Conserved domains on  [gi|1063725553|ref|NP_001329472|]
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L-tyrosine decarboxylase [Arabidopsis thaliana]

Protein Classification

PLP-dependent aminotransferase family protein( domain architecture ID 139552)

PLP-dependent aminotransferase family protein may combine pyridoxal phosphate with an alpha-amino acid to form a Schiff base or aldimine intermediate, which then acts as the substrate in a reaction such as a transamination, racemization, or decarboxylation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
2-388 0e+00

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member PLN02590:

Pssm-ID: 450240 [Multi-domain]  Cd Length: 539  Bit Score: 793.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553   2 EFGTGNGYSNGNGYTNGNGHTNGNGNYNGNGHVNGNGKANGAKVVKMKPMDSELLREQGHIMVDFIADYYKNLQDSPQDF 81
Cdd:PLN02590    5 EFGTGNGYSNGNGYTNGNGHTNGNGNYNGNGHVNGNGKANGAKVVKMKPMDSELLREQGHIMVDFIADYYKNLQDSPQDF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553  82 PVLSQVQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLT 161
Cdd:PLN02590   85 PVLSQVQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLT 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 162 SPAATELEIIVLDWLAKLLQLPDHFLSTGkgNGGGVIQGTGCEAVLVVVLAARDRILKKVGKTLLPQLVVYGSDQTHSSF 241
Cdd:PLN02590  165 SPAATELEIIVLDWLAKLLQLPDHFLSTG--NGGGVIQGTGCEAVLVVVLAARDRILKKVGKTLLPQLVVYGSDQTHSSF 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 242 RKACLIGGIHEENIRLLKTDSSTNYGMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHV 321
Cdd:PLN02590  243 RKACLIGGIHEENIRLLKTDSSTNYGMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHV 322
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063725553 322 DAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKV 388
Cdd:PLN02590  323 DAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKV 389
 
Name Accession Description Interval E-value
PLN02590 PLN02590
probable tyrosine decarboxylase
2-388 0e+00

probable tyrosine decarboxylase


Pssm-ID: 178200 [Multi-domain]  Cd Length: 539  Bit Score: 793.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553   2 EFGTGNGYSNGNGYTNGNGHTNGNGNYNGNGHVNGNGKANGAKVVKMKPMDSELLREQGHIMVDFIADYYKNLQDSPQDF 81
Cdd:PLN02590    5 EFGTGNGYSNGNGYTNGNGHTNGNGNYNGNGHVNGNGKANGAKVVKMKPMDSELLREQGHIMVDFIADYYKNLQDSPQDF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553  82 PVLSQVQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLT 161
Cdd:PLN02590   85 PVLSQVQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLT 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 162 SPAATELEIIVLDWLAKLLQLPDHFLSTGkgNGGGVIQGTGCEAVLVVVLAARDRILKKVGKTLLPQLVVYGSDQTHSSF 241
Cdd:PLN02590  165 SPAATELEIIVLDWLAKLLQLPDHFLSTG--NGGGVIQGTGCEAVLVVVLAARDRILKKVGKTLLPQLVVYGSDQTHSSF 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 242 RKACLIGGIHEENIRLLKTDSSTNYGMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHV 321
Cdd:PLN02590  243 RKACLIGGIHEENIRLLKTDSSTNYGMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHV 322
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063725553 322 DAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKV 388
Cdd:PLN02590  323 DAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKV 389
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
89-399 1.08e-104

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 315.13  E-value: 1.08e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553  89 PGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATEL 168
Cdd:pfam00282   1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHSPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 169 EIIVLDWLAKLLQLPDHFLSTGkgnGGGVIQGTGCEAVLVVVLAARDRILKKV---GK-----TLLPQLVVYGSDQTHSS 240
Cdd:pfam00282  81 ENVVMNWLGEMLGLPAEFLGQE---GGGVLQPGSSESNLLALLAARTKWIKRMkaaGKpadssGILAKLVAYTSDQAHSS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 241 FRKACLIGGIheeNIRLLKTDSstNYGMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLH 320
Cdd:pfam00282 158 IEKAALYGGV---KLREIPSDD--NGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLH 232
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063725553 321 VDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVKVSHVHHFVTN 399
Cdd:pfam00282 233 VDAAYGGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLGHTDSAYDTGHKQIP 311
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
56-384 3.11e-103

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 314.08  E-value: 3.11e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553  56 LREQGHIMVDFIADYYKNLqdspqDFPVLSQvQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYA 135
Cdd:COG0076     2 FRALLHQALDLAADYLAGL-----DRPVFGP-SPEELRAALDEPLPEEGLPPEEALAELEDLVLPGSVDWNHPRFLAFVT 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 136 SSTSVAGFLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLQLPDHFlstgkgngGGVIQGTGCEAVLVVVLAARD 215
Cdd:COG0076    76 GGTTPAALAADLLASALNQNMGDWDTSPAATELEREVVRWLADLLGLPEGA--------GGVFTSGGTEANLLALLAARD 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 216 RILKKVGKTL----LPQLVVYGSDQTHSSFRKACLIGGIHEENIRLLKTDSstNYGMPPESLEEAISHDLAKGFIPFFIC 291
Cdd:COG0076   148 RALARRVRAEglpgAPRPRIVVSEEAHSSVDKAARLLGLGRDALRKVPVDE--DGRMDPDALEAAIDEDRAAGLNPIAVV 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 292 ATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRY 371
Cdd:COG0076   226 ATAGTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALPSPELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDPE 305
                         330
                  ....*....|...
gi 1063725553 372 SLIDALKTNPEYL 384
Cdd:COG0076   306 LLREAFSFHASYL 318
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
130-368 1.58e-81

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 254.44  E-value: 1.58e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 130 YFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLQLPDhflstgkGNGGGVIQGTGCEAVLVV 209
Cdd:cd06450     1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLPS-------EDADGVFTSGGSESNLLA 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 210 VLAARDRILKKVGKTL---LPQLVVYGSDQTHSSFRKACLIGGIheeNIRLLKTDSstNYGMPPESLEEAISHDLAKGFI 286
Cdd:cd06450    74 LLAARDRARKRLKAGGgrgIDKLVIVCSDQAHVSVEKAAAYLDV---KVRLVPVDE--DGRMDPEALEAAIDEDKAEGLN 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 287 PFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLW 366
Cdd:cd06450   149 PIMVVATAGTTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVL 228

                  ..
gi 1063725553 367 VK 368
Cdd:cd06450   229 VR 230
 
Name Accession Description Interval E-value
PLN02590 PLN02590
probable tyrosine decarboxylase
2-388 0e+00

probable tyrosine decarboxylase


Pssm-ID: 178200 [Multi-domain]  Cd Length: 539  Bit Score: 793.14  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553   2 EFGTGNGYSNGNGYTNGNGHTNGNGNYNGNGHVNGNGKANGAKVVKMKPMDSELLREQGHIMVDFIADYYKNLQDSPQDF 81
Cdd:PLN02590    5 EFGTGNGYSNGNGYTNGNGHTNGNGNYNGNGHVNGNGKANGAKVVKMKPMDSELLREQGHIMVDFIADYYKNLQDSPQDF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553  82 PVLSQVQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLT 161
Cdd:PLN02590   85 PVLSQVQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLT 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 162 SPAATELEIIVLDWLAKLLQLPDHFLSTGkgNGGGVIQGTGCEAVLVVVLAARDRILKKVGKTLLPQLVVYGSDQTHSSF 241
Cdd:PLN02590  165 SPAATELEIIVLDWLAKLLQLPDHFLSTG--NGGGVIQGTGCEAVLVVVLAARDRILKKVGKTLLPQLVVYGSDQTHSSF 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 242 RKACLIGGIHEENIRLLKTDSSTNYGMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHV 321
Cdd:PLN02590  243 RKACLIGGIHEENIRLLKTDSSTNYGMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHV 322
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063725553 322 DAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKV 388
Cdd:PLN02590  323 DAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKV 389
PLN02880 PLN02880
tyrosine decarboxylase
48-387 0e+00

tyrosine decarboxylase


Pssm-ID: 215475 [Multi-domain]  Cd Length: 490  Bit Score: 582.25  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553  48 MKPMDSELLREQGHIMVDFIADYYKNLQDspqdFPVLSQVQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQS 127
Cdd:PLN02880    7 LRPMDAEQLRECGHRMVDFIADYYKSIEN----FPVLSQVQPGYLRELLPDSAPNQPETLDQVLDDVQAKILPGVTHWQS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 128 PSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLQLPDHFLSTGkgNGGGVIQGTGCEAVL 207
Cdd:PLN02880   83 PNYFAYYPSNSSVAGFLGEMLSAGLNIVGFSWITSPAATELEMIVLDWLAKLLNLPEQFLSTG--NGGGVIQGTASEAVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 208 VVVLAARDRILKKVGKTLLPQLVVYGSDQTHSSFRKACLIGGIHEENIRLLKTDSSTNYGMPPESLEEAISHDLAKGFIP 287
Cdd:PLN02880  161 VVLLAARDRVLRKVGKNALEKLVVYASDQTHSALQKACQIAGIHPENCRLLKTDSSTNYALAPELLSEAISTDLSSGLIP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 288 FFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWV 367
Cdd:PLN02880  241 FFLCATVGTTSSTAVDPLLELGKIAKSNGMWFHVDAAYAGSACICPEYRHYIDGVEEADSFNMNAHKWFLTNFDCSLLWV 320
                         330       340
                  ....*....|....*....|
gi 1063725553 368 KDRYSLIDALKTNPEYLEFK 387
Cdd:PLN02880  321 KDRNALIQSLSTNPEFLKNK 340
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
89-399 1.08e-104

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 315.13  E-value: 1.08e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553  89 PGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATEL 168
Cdd:pfam00282   1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHSPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 169 EIIVLDWLAKLLQLPDHFLSTGkgnGGGVIQGTGCEAVLVVVLAARDRILKKV---GK-----TLLPQLVVYGSDQTHSS 240
Cdd:pfam00282  81 ENVVMNWLGEMLGLPAEFLGQE---GGGVLQPGSSESNLLALLAARTKWIKRMkaaGKpadssGILAKLVAYTSDQAHSS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 241 FRKACLIGGIheeNIRLLKTDSstNYGMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLH 320
Cdd:pfam00282 158 IEKAALYGGV---KLREIPSDD--NGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLH 232
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063725553 321 VDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVKVSHVHHFVTN 399
Cdd:pfam00282 233 VDAAYGGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLGHTDSAYDTGHKQIP 311
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
56-384 3.11e-103

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 314.08  E-value: 3.11e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553  56 LREQGHIMVDFIADYYKNLqdspqDFPVLSQvQPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQSPSYFAYYA 135
Cdd:COG0076     2 FRALLHQALDLAADYLAGL-----DRPVFGP-SPEELRAALDEPLPEEGLPPEEALAELEDLVLPGSVDWNHPRFLAFVT 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 136 SSTSVAGFLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLQLPDHFlstgkgngGGVIQGTGCEAVLVVVLAARD 215
Cdd:COG0076    76 GGTTPAALAADLLASALNQNMGDWDTSPAATELEREVVRWLADLLGLPEGA--------GGVFTSGGTEANLLALLAARD 147
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 216 RILKKVGKTL----LPQLVVYGSDQTHSSFRKACLIGGIHEENIRLLKTDSstNYGMPPESLEEAISHDLAKGFIPFFIC 291
Cdd:COG0076   148 RALARRVRAEglpgAPRPRIVVSEEAHSSVDKAARLLGLGRDALRKVPVDE--DGRMDPDALEAAIDEDRAAGLNPIAVV 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 292 ATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRY 371
Cdd:COG0076   226 ATAGTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALPSPELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDPE 305
                         330
                  ....*....|...
gi 1063725553 372 SLIDALKTNPEYL 384
Cdd:COG0076   306 LLREAFSFHASYL 318
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
130-368 1.58e-81

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 254.44  E-value: 1.58e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 130 YFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATELEIIVLDWLAKLLQLPDhflstgkGNGGGVIQGTGCEAVLVV 209
Cdd:cd06450     1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLPS-------EDADGVFTSGGSESNLLA 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 210 VLAARDRILKKVGKTL---LPQLVVYGSDQTHSSFRKACLIGGIheeNIRLLKTDSstNYGMPPESLEEAISHDLAKGFI 286
Cdd:cd06450    74 LLAARDRARKRLKAGGgrgIDKLVIVCSDQAHVSVEKAAAYLDV---KVRLVPVDE--DGRMDPEALEAAIDEDKAEGLN 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 287 PFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLW 366
Cdd:cd06450   149 PIMVVATAGTTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVL 228

                  ..
gi 1063725553 367 VK 368
Cdd:cd06450   229 VR 230
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
165-368 1.55e-18

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 82.43  E-value: 1.55e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 165 ATELEiivlDWLAKLLQlpdhflstgKGNGGGVIQGTGCEAVLVVVLAArdrilkkvgktLLPQLVVYGSDQTHSSFRKA 244
Cdd:cd01494     2 LEELE----EKLARLLQ---------PGNDKAVFVPSGTGANEAALLAL-----------LGPGDEVIVDANGHGSRYWV 57
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 245 clIGGIHEENIRLLKTDsstNYGMPPESLEEAIshDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAA 324
Cdd:cd01494    58 --AAELAGAKPVPVPVD---DAGYGGLDVAILE--ELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAA 130
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1063725553 325 YAGNACICPEYRKFIDGienADSFNMNAHKWLFANQtCSPLWVK 368
Cdd:cd01494   131 SAGGASPAPGVLIPEGG---ADVVTFSLHKNLGGEG-GGVVIVK 170
PRK02769 PRK02769
histidine decarboxylase; Provisional
172-356 8.17e-09

histidine decarboxylase; Provisional


Pssm-ID: 235068 [Multi-domain]  Cd Length: 380  Bit Score: 56.97  E-value: 8.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 172 VLDWLAKLLQLPDHflstgkgNGGGVIQGTGCEAVLVVVLAARDrilkkvgktLLPQLVVYGSDQTHSSFRKACLIGGIH 251
Cdd:PRK02769   70 VMNFFAELFKIPFN-------ESWGYITNGGTEGNLYGCYLARE---------LFPDGTLYYSKDTHYSVSKIARLLRIK 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 252 EENIRllktdSSTNYGMPPESLEEAISHDLAKgfiPFFICATVGTTSSAAVDPLVPLGNIAKKYGI---WLHVDAAYAGn 328
Cdd:PRK02769  134 SRVIT-----SLPNGEIDYDDLISKIKENKNQ---PPIIFANIGTTMTGAIDNIKEIQEILKKIGIddyYIHADAALSG- 204
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1063725553 329 ACIC-----PEYrKFIDGIenaDSFNMNAHKWL 356
Cdd:PRK02769  205 MILPfvnnpPPF-SFADGI---DSIAISGHKFI 233
PLN03032 PLN03032
serine decarboxylase; Provisional
167-384 1.05e-05

serine decarboxylase; Provisional


Pssm-ID: 166673 [Multi-domain]  Cd Length: 374  Bit Score: 47.51  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 167 ELEIIVLDWLAKLLQL-PDHFLstgkgnggGVIQGTGCEAVLVVVLAARDRilkkvgktlLPQLVVYGSDQTHSSFRKAC 245
Cdd:PLN03032   66 QFEVGVLDWFARLWELeKDEYW--------GYITTCGTEGNLHGILVGREV---------FPDGILYASRESHYSVFKAA 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 246 LIGGIHEENIRLLKTdSSTNYgmppESLEEAISHDLAKgfiPFFICATVGTTSSAAVDPLVPLGNIAKKYGI-----WLH 320
Cdd:PLN03032  129 RMYRMEAVKVPTLPS-GEIDY----DDLERALAKNRDK---PAILNVNIGTTVKGAVDDLDRILRILKELGYtedrfYIH 200
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 321 VDAAYAGNAC----ICPE--YRKFIdgienaDSFNMNAHKWLFANQTCSPLWVKDRYslIDALKTNPEYL 384
Cdd:PLN03032  201 CDGALFGLMMpfvsRAPEvtFRKPI------GSVSVSGHKFLGCPMPCGVALTRKKH--VKALSQNVEYL 262
Beta_elim_lyase pfam01212
Beta-eliminating lyase;
197-359 2.62e-05

Beta-eliminating lyase;


Pssm-ID: 426128 [Multi-domain]  Cd Length: 288  Bit Score: 45.67  E-value: 2.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 197 VIQGTGCEAVLVVVLAARdrilkkvgktllPQLVVYGsDQTHSSF---RKACLIGGIHeenIRLLKTDSSTNygMPPESL 273
Cdd:pfam01212  53 VPSGTAANQLALMAHCQR------------GDEVICG-EPAHIHFdetGGHAELGGVQ---PRPLDGDEAGN--MDLEDL 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 274 EEAISHDLAKGFIPF-FICATVgTTSSAAVDPlVPLGN------IAKKYGIWLHVDAAYAGNACI---CP--EYRKFidg 341
Cdd:pfam01212 115 EAAIREVGADIFPPTgLISLEN-THNSAGGQV-VSLENlreiaaLAREHGIPVHLDGARFANAAValgVIvkEITSY--- 189
                         170
                  ....*....|....*...
gi 1063725553 342 ienADSFNMNAHKWLFAN 359
Cdd:pfam01212 190 ---ADSVTMCLSKGLGAP 204
PLN02263 PLN02263
serine decarboxylase
167-384 5.93e-05

serine decarboxylase


Pssm-ID: 177904 [Multi-domain]  Cd Length: 470  Bit Score: 45.19  E-value: 5.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 167 ELEIIVLDWLAKLLQLpdhflstGKGNGGGVIQGTGCEAVLVVVLaardrilkkVGKTLLPQLVVYGSDQTHSSFRKACL 246
Cdd:PLN02263  133 QFEVGVLDWFARLWEI-------EKNEYWGYITNCGTEGNLHGIL---------VGREVFPDGILYASRESHYSVFKAAR 196
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 247 IggiheENIRLLKTDSSTNYGMPPESLEEAISHDLAKgfiPFFICATVGTTSSAAVDPLVPLGNIAKKYG-----IWLHV 321
Cdd:PLN02263  197 M-----YRMECVKVDTLVSGEIDCADFKAKLLANKDK---PAIINVNIGTTVKGAVDDLDLVIKTLEECGfsqdrFYIHC 268
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063725553 322 DAAYAGnaCICP--------EYRKFIdgienaDSFNMNAHKWLFANQTCSPlwVKDRYSLIDALKTNPEYL 384
Cdd:PLN02263  269 DGALFG--LMMPfvkrapkvTFKKPI------GSVSVSGHKFVGCPMPCGV--QITRMEHINVLSSNVEYL 329
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
195-363 4.51e-03

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 38.83  E-value: 4.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 195 GGVIQGTGCEAVLVVVLAArdrilkkvgkTLLPQLVVYGSDQTHSSFRKACLIGGIheeNIRLLKTDSSTNYGMPPESLE 274
Cdd:pfam00155  64 AAVVFGSGAGANIEALIFL----------LANPGDAILVPAPTYASYIRIARLAGG---EVVRYPLYDSNDFHLDFDALE 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725553 275 EAIShDLAKGFI---PFFICATVgttssAAVDPLVPLGNIAKKYGIWLHVDAAYAGNAcicpeyrkFIDGIENADSFNMN 351
Cdd:pfam00155 131 AALK-EKPKVVLhtsPHNPTGTV-----ATLEELEKLLDLAKEHNILLLVDEAYAGFV--------FGSPDAVATRALLA 196
                         170
                  ....*....|..
gi 1063725553 352 AHKWLFANQTCS 363
Cdd:pfam00155 197 EGPNLLVVGSFS 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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