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Conserved domains on  [gi|1063725541|ref|NP_001329155|]
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no pollen germination related 2 [Arabidopsis thaliana]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Spy super family cl27809
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 596-729 1.60e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG3914:

Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 74.26  E-value: 1.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 596 HDLAHIYINLSQWRDAESCLSRSRLIAPYSSVRYHIEGVLYNRRGQLEEAMEAFTTALDIDPMHVPSLTSKAEILLEVGn 675
Cdd:COG3914    82 ELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLG- 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063725541 676 RSGIAVvrSFLMEALRIDRLNHSAWYNLGKMFKAEGSVssmQEAVECFQAAVTL 729
Cdd:COG3914   161 RLEEAI--AALRRALELDPDNAEALNNLGNALQDLGRL---EEAIAAYRRALEL 209
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 455-693 6.76e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.43  E-value: 6.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 455 QALESADMTNPRVVHRLALENAEQRKLDSALAYAKEALKLgAESDLEVWLLLARVLSAQKRFSDAETIVDAALNETGKWE 534
Cdd:COG2956    66 QKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLEL-DPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENA 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 535 QgkLLRLKAKLRLAKGEVKDAIKTYTQLLALLqvqsksfnsakklpKGYVKELMSlelgtwhdLAHIYINLSQWRDAESC 614
Cdd:COG2956   145 H--AYCELAELYLEQGDYDEAIEALEKALKLD--------------PDCARALLL--------LAELYLEQGDYEEAIAA 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 615 LSRSRLIAP-YSSVRYHIeGVLYNRRGQLEEAMEAFTTALDIDPmHVPSLTSKAEILLEvgnRSGIAVVRSFLMEALRID 693
Cdd:COG2956   201 LERALEQDPdYLPALPRL-AELYEKLGDPEEALELLRKALELDP-SDDLLLALADLLER---KEGLEAALALLERQLRRH 275
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 596-729 1.60e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 74.26  E-value: 1.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 596 HDLAHIYINLSQWRDAESCLSRSRLIAPYSSVRYHIEGVLYNRRGQLEEAMEAFTTALDIDPMHVPSLTSKAEILLEVGn 675
Cdd:COG3914    82 ELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLG- 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063725541 676 RSGIAVvrSFLMEALRIDRLNHSAWYNLGKMFKAEGSVssmQEAVECFQAAVTL 729
Cdd:COG3914   161 RLEEAI--AALRRALELDPDNAEALNNLGNALQDLGRL---EEAIAAYRRALEL 209
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 455-693 6.76e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.43  E-value: 6.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 455 QALESADMTNPRVVHRLALENAEQRKLDSALAYAKEALKLgAESDLEVWLLLARVLSAQKRFSDAETIVDAALNETGKWE 534
Cdd:COG2956    66 QKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLEL-DPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENA 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 535 QgkLLRLKAKLRLAKGEVKDAIKTYTQLLALLqvqsksfnsakklpKGYVKELMSlelgtwhdLAHIYINLSQWRDAESC 614
Cdd:COG2956   145 H--AYCELAELYLEQGDYDEAIEALEKALKLD--------------PDCARALLL--------LAELYLEQGDYEEAIAA 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 615 LSRSRLIAP-YSSVRYHIeGVLYNRRGQLEEAMEAFTTALDIDPmHVPSLTSKAEILLEvgnRSGIAVVRSFLMEALRID 693
Cdd:COG2956   201 LERALEQDPdYLPALPRL-AELYEKLGDPEEALELLRKALELDP-SDDLLLALADLLER---KEGLEAALALLERQLRRH 275
TPR_19 pfam14559
Tetratricopeptide repeat;
478-530 1.21e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 37.95  E-value: 1.21e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063725541 478 QRKLDSALAYAKEALKLgAESDLEVWLLLARVLSAQKRFSDAETIVDAALNET 530
Cdd:pfam14559   1 EGDYAEALELLEQALAE-DPDNAEARLGLAEALLALGRLDEAEALLAALPAAD 52
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 557-729 4.70e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.45  E-value: 4.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 557 KTYTQLLALLQVQsKSFNSAKKLpkGYVKELMSLelgtwhDLAHIYINLSQWRDA-ESCLSRSRLIAPYSSVRYHIEGVL 635
Cdd:TIGR02917  64 KIYLALGDYAAAE-KELRKALSL--GYPKNQVLP------LLARAYLLQGKFQQVlDELPGKTLLDDEGAAELLALRGLA 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 636 YNRRGQLEEAMEAFTTALDIDPMHVPSLTSKAEILLEVGNRSGiavVRSFLMEALRIDRLNHSAWYNLGKMfkaEGSVSS 715
Cdd:TIGR02917 135 YLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDE---ARALIDEVLTADPGNVDALLLKGDL---LLSLGN 208

                         170
                  ....*....|....
gi 1063725541 716 MQEAVECFQAAVTL 729
Cdd:TIGR02917 209 IELALAAYRKAIAL 222
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 478-663 5.38e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 5.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 478 QRKLDSALAYAKEALKLgAESDLEVWLLLARVLSAQKRFSDAETIVDAALNETGKweQGKLLRLKAKLRLAKGEVKDAIK 557
Cdd:TIGR02917 138 LGQLELAQKSYEQALAI-DPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPG--NVDALLLKGDLLLSLGNIELALA 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 558 TYTQLLALlqvqsksfnsAKKLPKGYVKelmslelgtwhdLAHIYINLSQWRDAESCLSRSRLIAPYSSVRYHIEGVLYN 637
Cdd:TIGR02917 215 AYRKAIAL----------RPNNIAVLLA------------LATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDF 272

                         170       180
                  ....*....|....*....|....*.
gi 1063725541 638 RRGQLEEAMEAFTTALDIDPMHVPSL 663
Cdd:TIGR02917 273 QKKNYEDARETLQDALKSAPEYLPAL 298
 
Name Accession Description Interval E-value
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 596-729 1.60e-13

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 74.26  E-value: 1.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 596 HDLAHIYINLSQWRDAESCLSRSRLIAPYSSVRYHIEGVLYNRRGQLEEAMEAFTTALDIDPMHVPSLTSKAEILLEVGn 675
Cdd:COG3914    82 ELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLG- 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063725541 676 RSGIAVvrSFLMEALRIDRLNHSAWYNLGKMFKAEGSVssmQEAVECFQAAVTL 729
Cdd:COG3914   161 RLEEAI--AALRRALELDPDNAEALNNLGNALQDLGRL---EEAIAAYRRALEL 209
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 471-735 2.35e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 70.91  E-value: 2.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 471 LALENAEQRKLDSALAYAKEALKLGAEsDLEVWLLLARVLSAQKRFSDAETIVDAALNETGKWEQgkllrlkaklrlakg 550
Cdd:COG2956    14 KGLNYLLNGQPDKAIDLLEEALELDPE-TVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAE--------------- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 551 evkdaiktYTQLLALLQVQSKSFNSAKKLpkgyVKELMSLE---LGTWHDLAHIYINLSQWRDAESCLSRSRLIAPYSSV 627
Cdd:COG2956    78 --------ALLELAQDYLKAGLLDRAEEL----LEKLLELDpddAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 628 RYHIEGVLYNRRGQLEEAMEAFTTALDIDPMHVPSLTSKAEILLEVGNrsgIAVVRSFLMEALRIDRLNHSAWYNLGKMF 707
Cdd:COG2956   146 AYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGD---YEEAIAALERALEQDPDYLPALPRLAELY 222

                         250       260
                  ....*....|....*....|....*...
gi 1063725541 708 KAEGSVssmQEAVECFQAAVTLEETMPV 735
Cdd:COG2956   223 EKLGDP---EEALELLRKALELDPSDDL 247
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
594-730 1.20e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.49  E-value: 1.20e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 594 TWHDLAHIYINLSQWRDAESCLSRSRLIAPYSSVRYHIEGVLYNRRGQLEEAMEAFTTALDIDPMHVPSLTSKAEILLEV 673
Cdd:COG0457    10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQAL 89

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063725541 674 GNRSGiAVvrSFLMEALRIDRLNHSAWYNLGKMFKAEGSVssmQEAVECFQAAVTLE 730
Cdd:COG0457    90 GRYEE-AL--EDYDKALELDPDDAEALYNLGLALLELGRY---DEAIEAYERALELD 140
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
594-726 1.56e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.95  E-value: 1.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 594 TWHDLAHIYINLSQWRDAESCLSRSRLIAPYSSVRYHIEGVLYNRRGQLEEAMEAFTTALDIDPMHVPSLTSKAEILLEV 673
Cdd:COG0457    44 ALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLEL 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063725541 674 GNRSGiavVRSFLMEALRIDRLNHSAWYNLGKMFKAEGsvsSMQEAVECFQAA 726
Cdd:COG0457   124 GRYDE---AIEAYERALELDPDDADALYNLGIALEKLG---RYEEALELLEKL 170
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 455-693 6.76e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.43  E-value: 6.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 455 QALESADMTNPRVVHRLALENAEQRKLDSALAYAKEALKLgAESDLEVWLLLARVLSAQKRFSDAETIVDAALNETGKWE 534
Cdd:COG2956    66 QKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLEL-DPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENA 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 535 QgkLLRLKAKLRLAKGEVKDAIKTYTQLLALLqvqsksfnsakklpKGYVKELMSlelgtwhdLAHIYINLSQWRDAESC 614
Cdd:COG2956   145 H--AYCELAELYLEQGDYDEAIEALEKALKLD--------------PDCARALLL--------LAELYLEQGDYEEAIAA 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 615 LSRSRLIAP-YSSVRYHIeGVLYNRRGQLEEAMEAFTTALDIDPmHVPSLTSKAEILLEvgnRSGIAVVRSFLMEALRID 693
Cdd:COG2956   201 LERALEQDPdYLPALPRL-AELYEKLGDPEEALELLRKALELDP-SDDLLLALADLLER---KEGLEAALALLERQLRRH 275
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 469-703 5.61e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.15  E-value: 5.61e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 469 HRLALENAEQRKLDSALAYAKEALKLGAESDLEVW------LLLARVLSAQKRFSDAETIVDAALNETGKWEQGKLLRLK 542
Cdd:COG3914     5 ALLALAALAAAALLAAAAAAELALAAELEAAALAAalglalLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 543 AKLRLAKGEVKDAIKTYTQLLALlqvqsksfnsakklpkgyvkelMSLELGTWHDLAHIYINLSQWRDAESCLSRSRLIA 622
Cdd:COG3914    85 ALLLQALGRYEEALALYRRALAL----------------------NPDNAEALFNLGNLLLALGRLEEALAALRRALALN 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 623 PYSSVRYHIEGVLYNRRGQLEEAMEAFTTALDIDPMHVPSLTSKAEILLEVGNRS-GIAVVRsflmEALRIDRLNHSAWY 701
Cdd:COG3914   143 PDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEeAIAAYR----RALELDPDNADAHS 218


                  ..
gi 1063725541 702 NL 703
Cdd:COG3914   219 NL 220
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
621-730 9.10e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.86  E-value: 9.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 621 IAPYSSVRYHIEGVLYNRRGQLEEAMEAFTTALDIDPMHVPSLTSKAEILLEVGNRSGiavVRSFLMEALRIDRLNHSAW 700
Cdd:COG0457     3 LDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEE---ALADYEQALELDPDDAEAL 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1063725541 701 YNLGKMFKAEGSVssmQEAVECFQAAVTLE 730
Cdd:COG0457    80 NNLGLALQALGRY---EEALEDYDKALELD 106
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 563-675 2.76e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.19  E-value: 2.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 563 LALLQVQSKSFNSAKKLpkgyVKELMSLE---LGTWHDLAHIYINLSQWRDAESCLSRSRLIAPYSSVRYHIEGVLYNRR 639
Cdd:COG4783    10 LAQALLLAGDYDEAEAL----LEKALELDpdnPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKA 85

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1063725541 640 GQLEEAMEAFTTALDIDPMHVPSLTSKAEILLEVGN 675
Cdd:COG4783    86 GDYDEALALLEKALKLDPEHPEAYLRLARAYRALGR 121
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 633-729 3.01e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 50.00  E-value: 3.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 633 GVLYNRRGQLEEAMEAFTTALDIDPMHVPSLTSKAEILLEVGNrsgIAVVRSFLMEALRIDRLNHSAWYNLGKMFKAEGs 712
Cdd:COG4235    24 GRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGD---TEEAEELLERALALDPDNPEALYLLGLAAFQQG- 99

                          90
                  ....*....|....*..
gi 1063725541 713 vsSMQEAVECFQAAVTL 729
Cdd:COG4235   100 --DYAEAIAAWQKLLAL 114
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
499-676 6.61e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 6.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 499 DLEVWLLLARVLSAQKRFSDAETIVDAALNETGKWEQgkLLRLKAKLRLAKGEVKDAIKTYTQLLALlqvqskSFNSAKk 578
Cdd:COG0457     7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAE--ALYNLGLAYLRLGRYEEALADYEQALEL------DPDDAE- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 579 lpkgyvkelmslelgTWHDLAHIYINLSQWRDAESCLSRSRLIAPYSSVRYHIEGVLYNRRGQLEEAMEAFTTALDIDPM 658
Cdd:COG0457    78 ---------------ALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPD 142

                         170
                  ....*....|....*...
gi 1063725541 659 HVPSLTSKAEILLEVGNR 676
Cdd:COG0457   143 DADALYNLGIALEKLGRY 160
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 595-730 7.22e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.03  E-value: 7.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 595 WHDLAHIYINLSQWRDAESCLSRSRLIAPYSSVRYHIEGVLYNRRGQLEEAMEAFTTALDIDPMHVPSLTSKAEILLEVG 674
Cdd:COG4783     7 LYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAG 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063725541 675 NRSGiAVvrSFLMEALRIDRLNHSAWYNLGKMFKAEGsvsSMQEAVECFQAAVTLE 730
Cdd:COG4783    87 DYDE-AL--ALLEKALKLDPEHPEAYLRLARAYRALG---RPDEAIAALEKALELD 136
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
601-693 2.43e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 46.32  E-value: 2.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 601 IYINLSQWRDAESCLSRSRLIAPYSSVRYHIEGVLYNRRGQLEEAmEAFTTALDIDPMHVPSLTSKAEILLEVGNRSGia 680
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDE-- 77

                          90
                  ....*....|...
gi 1063725541 681 vVRSFLMEALRID 693
Cdd:COG3063    78 -ALAYLERALELD 89
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
635-730 7.39e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.16  E-value: 7.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 635 LYNRRGQLEEAMEAFTTALDIDPMHVPSLTSKAEILLEVGNRSGiAVVrsfLMEALRIDRLNHSAWYNLGKMFKAEGSVs 714
Cdd:COG3063     1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDE-AIA---LEKALKLDPNNAEALLNLAELLLELGDY- 75

                          90
                  ....*....|....*.
gi 1063725541 715 smQEAVECFQAAVTLE 730
Cdd:COG3063    76 --DEALAYLERALELD 89
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 634-730 5.91e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.18  E-value: 5.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 634 VLYNRRGQLEEAMEAFTTALDIDPMHVPSLTSKAEILLEVGNRSGiavVRSFLMEALRIDRLNHSAWYNLGKMFKAEGsv 713
Cdd:COG5010    62 NLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDE---AKEYYEKALALSPDNPNAYSNLAALLLSLG-- 136

                          90
                  ....*....|....*..
gi 1063725541 714 sSMQEAVECFQAAVTLE 730
Cdd:COG5010   137 -QDDEAKAALQRALGTS 152
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
464-654 1.35e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.23  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 464 NPRVVHRLALENAEQRKLDSALAYAKEALKLgAESDLEVWLLLARVLSAQKRFSDAETIVDAALNEtgKWEQGKLLRLKA 543
Cdd:COG0457     7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALEL-DPDDAEALYNLGLAYLRLGRYEEALADYEQALEL--DPDDAEALNNLG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 544 KLRLAKGEVKDAIKTYTQLLALlqvqskSFNSAKklpkgyvkelmslelgTWHDLAHIYINLSQWRDAESCLSRSRLIAP 623
Cdd:COG0457    84 LALQALGRYEEALEDYDKALEL------DPDDAE----------------ALYNLGLALLELGRYDEAIEAYERALELDP 141

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1063725541 624 YSSVRYHIEGVLYNRRGQLEEAMEAFTTALD 654
Cdd:COG0457   142 DDADALYNLGIALEKLGRYEEALELLEKLEA 172
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 445-528 1.68e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.98  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 445 ERIARQSEGIQALESA---DMTNPRVVHRLALENAEQRKLDSALAYAKEALKLGAEsDLEVWLLLARVLSAQKRFSDAET 521
Cdd:COG3914    89 QALGRYEEALALYRRAlalNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPD-FAEAYLNLGEALRRLGRLEEAIA 167


                  ....*..
gi 1063725541 522 IVDAALN 528
Cdd:COG3914   168 ALRRALE 174
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 601-695 4.05e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.48  E-value: 4.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 601 IYINLSQWRDAESCLSRSRLIAPYSSVRYHIEGVLYNRRGQLEEAMEAFTTALDIDPMHVPSLTSKAEILLEVGNRsgiA 680
Cdd:COG5010    63 LYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQD---D 139

                          90
                  ....*....|....*
gi 1063725541 681 VVRSFLMEALRIDRL 695
Cdd:COG5010   140 EAKAALQRALGTSPL 154
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 497-657 8.72e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.18  E-value: 8.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 497 ESDLEVWLLLARVLSAQKRFSDAETIVDAALNETGKWEQgkllrlkaklrlakgevkdaiktYTQLLALLQVQSKSFNSA 576
Cdd:COG4783     1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPE-----------------------AFALLGEILLQLGDLDEA 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 577 KKlpkgYVKELMSL---ELGTWHDLAHIYINLSQWRDAESCLSRSRLIAPYSSVRYHIEGVLYNRRGQLEEAMEAFTTAL 653
Cdd:COG4783    58 IV----LLHEALELdpdEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKAL 133


                  ....
gi 1063725541 654 DIDP 657
Cdd:COG4783   134 ELDP 137
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
594-675 9.10e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.44  E-value: 9.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 594 TWHDLAHIYINLSQWRDAESCLSRSRLIAPYSSVRYHIEGVLYNRRGQLEEAMEAFTTALDIDPMHVPSLTSKAEILLEV 673
Cdd:COG4785    75 LYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYL 154


                  ..
gi 1063725541 674 GN 675
Cdd:COG4785   155 GR 156
TPR_19 pfam14559
Tetratricopeptide repeat;
478-530 1.21e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 37.95  E-value: 1.21e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063725541 478 QRKLDSALAYAKEALKLgAESDLEVWLLLARVLSAQKRFSDAETIVDAALNET 530
Cdd:pfam14559   1 EGDYAEALELLEQALAE-DPDNAEARLGLAEALLALGRLDEAEALLAALPAAD 52
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 454-565 4.21e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.25  E-value: 4.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 454 IQALESADMTNPRVVHRLALENAEQRKLDSALAYAKEALKLGAEsDLEVWLLLARVLSAQKRFSDAETIVDAALNETGkw 533
Cdd:COG4783    27 LEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPD-EPEARLNLGLALLKAGDYDEALALLEKALKLDP-- 103

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1063725541 534 EQGKLLRLKAKLRLAKGEVKDAIKTYTQLLAL 565
Cdd:COG4783   104 EHPEAYLRLARAYRALGRPDEAIAALEKALEL 135
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 557-729 4.70e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.45  E-value: 4.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 557 KTYTQLLALLQVQsKSFNSAKKLpkGYVKELMSLelgtwhDLAHIYINLSQWRDA-ESCLSRSRLIAPYSSVRYHIEGVL 635
Cdd:TIGR02917  64 KIYLALGDYAAAE-KELRKALSL--GYPKNQVLP------LLARAYLLQGKFQQVlDELPGKTLLDDEGAAELLALRGLA 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 636 YNRRGQLEEAMEAFTTALDIDPMHVPSLTSKAEILLEVGNRSGiavVRSFLMEALRIDRLNHSAWYNLGKMfkaEGSVSS 715
Cdd:TIGR02917 135 YLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDE---ARALIDEVLTADPGNVDALLLKGDL---LLSLGN 208

                         170
                  ....*....|....
gi 1063725541 716 MQEAVECFQAAVTL 729
Cdd:TIGR02917 209 IELALAAYRKAIAL 222
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 478-663 5.38e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 5.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 478 QRKLDSALAYAKEALKLgAESDLEVWLLLARVLSAQKRFSDAETIVDAALNETGKweQGKLLRLKAKLRLAKGEVKDAIK 557
Cdd:TIGR02917 138 LGQLELAQKSYEQALAI-DPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPG--NVDALLLKGDLLLSLGNIELALA 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725541 558 TYTQLLALlqvqsksfnsAKKLPKGYVKelmslelgtwhdLAHIYINLSQWRDAESCLSRSRLIAPYSSVRYHIEGVLYN 637
Cdd:TIGR02917 215 AYRKAIAL----------RPNNIAVLLA------------LATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDF 272

                         170       180
                  ....*....|....*....|....*.
gi 1063725541 638 RRGQLEEAMEAFTTALDIDPMHVPSL 663
Cdd:TIGR02917 273 QKKNYEDARETLQDALKSAPEYLPAL 298
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 595-658 9.87e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 37.63  E-value: 9.87e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063725541 595 WHDLAHIYINLSQWRDAESCLSRSRLIAPYSSVRYHIEGVLYNRRGQLEEAMEAFTTALDIDPM 658
Cdd:COG5010    91 YYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSPL 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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