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Conserved domains on  [gi|1063720767|ref|NP_001328634|]
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transducin family protein / WD-40 repeat family protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
134-474 3.10e-34

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.11  E-value: 3.10e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 134 FSTDGSLFIAGFQGSRIRIYNVEKGWKVQKdilAKSLRWTVTDTSLSPDQRNLVYASMSPIVHIVDVGSGsteshanvTE 213
Cdd:COG2319   128 FSPDGKTLASGSADGTVRLWDLATGKLLRT---LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--------KL 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 214 IHdgldfssdEDGGYSFGIFSVKFSTDGREVVAGSSDDSIYVYDLEANRVSLRTVAHTSDVNTVCFADeSGNLILSGSDD 293
Cdd:COG2319   197 LR--------TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 294 NLCKVWDrrcfIGRDKPAGVLVGHLEGVTFIDSRGDGRYFISNGKDQTIKLWDIRKmsssaparhevlrnyewdyrwmdy 373
Cdd:COG2319   268 GTVRLWD----LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT------------------------ 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 374 pteardlkhplDQSVSTYKGHSVLRTLIRcyFSPahsTGqKYIYTGSNDSSVYIYDLVSGDKVAVLKHHSSPVRDCNWHP 453
Cdd:COG2319   320 -----------GKLLRTLTGHTGAVRSVA--FSP---DG-KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382

                         330       340
                  ....*....|....*....|.
gi 1063720767 454 YYPTLISSSWDGDLVKWEFPG 474
Cdd:COG2319   383 DGRTLASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
134-474 3.10e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.11  E-value: 3.10e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 134 FSTDGSLFIAGFQGSRIRIYNVEKGWKVQKdilAKSLRWTVTDTSLSPDQRNLVYASMSPIVHIVDVGSGsteshanvTE 213
Cdd:COG2319   128 FSPDGKTLASGSADGTVRLWDLATGKLLRT---LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--------KL 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 214 IHdgldfssdEDGGYSFGIFSVKFSTDGREVVAGSSDDSIYVYDLEANRVSLRTVAHTSDVNTVCFADeSGNLILSGSDD 293
Cdd:COG2319   197 LR--------TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 294 NLCKVWDrrcfIGRDKPAGVLVGHLEGVTFIDSRGDGRYFISNGKDQTIKLWDIRKmsssaparhevlrnyewdyrwmdy 373
Cdd:COG2319   268 GTVRLWD----LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT------------------------ 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 374 pteardlkhplDQSVSTYKGHSVLRTLIRcyFSPahsTGqKYIYTGSNDSSVYIYDLVSGDKVAVLKHHSSPVRDCNWHP 453
Cdd:COG2319   320 -----------GKLLRTLTGHTGAVRSVA--FSP---DG-KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382

                         330       340
                  ....*....|....*....|.
gi 1063720767 454 YYPTLISSSWDGDLVKWEFPG 474
Cdd:COG2319   383 DGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 133-465 3.52e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.45  E-value: 3.52e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 133 QFSTDGSLFIAGFQGSRIRIYNVEKGWKVQKDILAKSlrwTVTDTSLSPDQRNLVYASMSPIVHIVDVGSGSTeshanVT 212
Cdd:cd00200    16 AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG---PVRDVAASADGTYLASGSSDKTIRLWDLETGEC-----VR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 213 EIHdgldfssdedgGYSFGIFSVKFSTDGREVVAGSSDDSIYVYDLEANRVSLRTVAHTSDVNTVCFaDESGNLILSGSD 292
Cdd:cd00200    88 TLT-----------GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASSSQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 293 DNLCKVWDRRCFigrdKPAGVLVGHLEGVTFIDSRGDGRYFISNGKDQTIKLWDIRKmsssaparhevlrnyewdyrwmd 372
Cdd:cd00200   156 DGTIKLWDLRTG----KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST----------------------- 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 373 ypteardlkhplDQSVSTYKGHSVlrtliRCYfSPAHSTGQKYIYTGSNDSSVYIYDLVSGDKVAVLKHHSSPVRDCNWH 452
Cdd:cd00200   209 ------------GKCLGTLRGHEN-----GVN-SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS 270

                         330
                  ....*....|...
gi 1063720767 453 PYYPTLISSSWDG 465
Cdd:cd00200   271 PDGKRLASGSADG 283
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 134-428 3.72e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.86  E-value: 3.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 134 FSTDGSLFIAGFQGSRIRIYNVEKGWKVQKDI------LA-----KSLRWTvtdtslSPDQRNLVYASMSPIVHIVDVGS 202
Cdd:PLN00181  491 FDRDGEFFATAGVNKKIKIFECESIIKDGRDIhypvveLAsrsklSGICWN------SYIKSQVASSNFEGVVQVWDVAR 564

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 203 GSTeshanVTEIHDgldfssdedggYSFGIFSVKFSTDGREVVAGSSDDSIYVYDLEANRVSLRTVAHTSDVNTVCFADE 282
Cdd:PLN00181  565 SQL-----VTEMKE-----------HEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSE 628

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 283 SGNLILSGSDDNLCKVWDRRcfiGRDKPAGVLVGHLEGVTFIDSRgDGRYFISNGKDQTIKLWDirkMSSSAPARHEVlr 362
Cdd:PLN00181  629 SGRSLAFGSADHKVYYYDLR---NPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWD---LSMSISGINET-- 699

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063720767 363 nyewdyrwmdypteardlkhPLdqsvSTYKGHSVLRTLIrcyfspAHSTGQKYIYTGSNDSSVYIY 428
Cdd:PLN00181  700 --------------------PL----HSFMGHTNVKNFV------GLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 432-471 1.16e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.16e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1063720767  432 SGDKVAVLKHHSSPVRDCNWHPYYPTLISSSWDGDLVKWE 471
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
269-300 3.77e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.77e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1063720767 269 AHTSDVNTVCFaDESGNLILSGSDDNLCKVWD 300
Cdd:pfam00400   9 GHTGSVTSLAF-SPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
134-474 3.10e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.11  E-value: 3.10e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 134 FSTDGSLFIAGFQGSRIRIYNVEKGWKVQKdilAKSLRWTVTDTSLSPDQRNLVYASMSPIVHIVDVGSGsteshanvTE 213
Cdd:COG2319   128 FSPDGKTLASGSADGTVRLWDLATGKLLRT---LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--------KL 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 214 IHdgldfssdEDGGYSFGIFSVKFSTDGREVVAGSSDDSIYVYDLEANRVSLRTVAHTSDVNTVCFADeSGNLILSGSDD 293
Cdd:COG2319   197 LR--------TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSAD 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 294 NLCKVWDrrcfIGRDKPAGVLVGHLEGVTFIDSRGDGRYFISNGKDQTIKLWDIRKmsssaparhevlrnyewdyrwmdy 373
Cdd:COG2319   268 GTVRLWD----LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT------------------------ 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 374 pteardlkhplDQSVSTYKGHSVLRTLIRcyFSPahsTGqKYIYTGSNDSSVYIYDLVSGDKVAVLKHHSSPVRDCNWHP 453
Cdd:COG2319   320 -----------GKLLRTLTGHTGAVRSVA--FSP---DG-KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382

                         330       340
                  ....*....|....*....|.
gi 1063720767 454 YYPTLISSSWDGDLVKWEFPG 474
Cdd:COG2319   383 DGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 133-465 3.52e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.45  E-value: 3.52e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 133 QFSTDGSLFIAGFQGSRIRIYNVEKGWKVQKDILAKSlrwTVTDTSLSPDQRNLVYASMSPIVHIVDVGSGSTeshanVT 212
Cdd:cd00200    16 AFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG---PVRDVAASADGTYLASGSSDKTIRLWDLETGEC-----VR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 213 EIHdgldfssdedgGYSFGIFSVKFSTDGREVVAGSSDDSIYVYDLEANRVSLRTVAHTSDVNTVCFaDESGNLILSGSD 292
Cdd:cd00200    88 TLT-----------GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASSSQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 293 DNLCKVWDRRCFigrdKPAGVLVGHLEGVTFIDSRGDGRYFISNGKDQTIKLWDIRKmsssaparhevlrnyewdyrwmd 372
Cdd:cd00200   156 DGTIKLWDLRTG----KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST----------------------- 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 373 ypteardlkhplDQSVSTYKGHSVlrtliRCYfSPAHSTGQKYIYTGSNDSSVYIYDLVSGDKVAVLKHHSSPVRDCNWH 452
Cdd:cd00200   209 ------------GKCLGTLRGHEN-----GVN-SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS 270

                         330
                  ....*....|...
gi 1063720767 453 PYYPTLISSSWDG 465
Cdd:cd00200   271 PDGKRLASGSADG 283
WD40 COG2319
WD40 repeat [General function prediction only];
126-477 9.68e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.18  E-value: 9.68e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 126 DSRAYVSQFSTDGSLFIAGFQGSRIRIYNVEKGWKVQKDILAKSlrwTVTDTSLSPDQRNLVYASMSPIVHIVDVGSGST 205
Cdd:COG2319    78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG---AVRSVAFSPDGKTLASGSADGTVRLWDLATGKL 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 206 eshanVTEIHdgldfssdedgGYSFGIFSVKFSTDGREVVAGSSDDSIYVYDLEANRVSLRTVAHTSDVNTVCFADeSGN 285
Cdd:COG2319   155 -----LRTLT-----------GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGK 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 286 LILSGSDDNLCKVWDrrcfIGRDKPAGVLVGHLEGVTFIDSRGDGRYFISNGKDQTIKLWDIRKmsssaparhevlrnye 365
Cdd:COG2319   218 LLASGSADGTVRLWD----LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAT---------------- 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 366 wdyrwmdypteardlkhplDQSVSTYKGHSVLRTLIRcyFSPahstGQKYIYTGSNDSSVYIYDLVSGDKVAVLKHHSSP 445
Cdd:COG2319   278 -------------------GELLRTLTGHSGGVNSVA--FSP----DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1063720767 446 VRDCNWHPYYPTLISSSWDGDLVKWEFPGSGE 477
Cdd:COG2319   333 VRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 227-472 2.16e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.75  E-value: 2.16e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 227 GYSFGIFSVKFSTDGREVVAGSSDDSIYVYDLEANRVSLRTVAHTSDVNTV-CFADesGNLILSGSDDNLCKVWDrrcfI 305
Cdd:cd00200     7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVaASAD--GTYLASGSSDKTIRLWD----L 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 306 GRDKPAGVLVGHLEGVTFIDSRGDGRYFISNGKDQTIKLWDIRKmsssaparhevlrnyewdyrwmdypteardlkhplD 385
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVET-----------------------------------G 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 386 QSVSTYKGHSvlRTLIRCYFSPahstGQKYIYTGSNDSSVYIYDLVSGDKVAVLKHHSSPVRDCNWHPYYPTLISSSWDG 465
Cdd:cd00200   126 KCLTTLRGHT--DWVNSVAFSP----DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199


                  ....*..
gi 1063720767 466 DLVKWEF 472
Cdd:cd00200   200 TIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
127-465 1.30e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.93  E-value: 1.30e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 127 SRAYVSQFSTDGSLFIAGFQGSRIRIYNVEKGWKVQKDILAKSLRWTVTdtsLSPDQRNLVYASMSPIVHIVDVGSGSTE 206
Cdd:COG2319    37 AAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVA---FSPDGRLLASASADGTVRLWDLATGLLL 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 207 SHANvteihdgldfssdedgGYSFGIFSVKFSTDGREVVAGSSDDSIYVYDLEANRVSLRTVAHTSDVNTVCFADeSGNL 286
Cdd:COG2319   114 RTLT----------------GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 287 ILSGSDDNLCKVWDrrcfIGRDKPAGVLVGHLEGVTFIDSRGDGRYFISNGKDQTIKLWDIRKmsssaparhevlrnyew 366
Cdd:COG2319   177 LASGSDDGTVRLWD----LATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT----------------- 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 367 dyrwmdypteardlkhplDQSVSTYKGHSVLRTLIRcyFSPahstGQKYIYTGSNDSSVYIYDLVSGDKVAVLKHHSSPV 446
Cdd:COG2319   236 ------------------GKLLRTLTGHSGSVRSVA--FSP----DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGV 291

                         330
                  ....*....|....*....
gi 1063720767 447 RDCNWHPYYPTLISSSWDG 465
Cdd:COG2319   292 NSVAFSPDGKLLASGSDDG 310
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 134-346 3.88e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 3.88e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 134 FSTDGSLFIAGFQGSRIRIYNVEKGwKVQKDILAKSlRWtVTDTSLSPDQRNLVYASMSPIVHIVDVGSGSTeshanVTE 213
Cdd:cd00200   101 FSPDGRILSSSSRDKTIKVWDVETG-KCLTTLRGHT-DW-VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC-----VAT 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 214 IHdgldfssdedgGYSFGIFSVKFSTDGREVVAGSSDDSIYVYDLEANRVSLRTVAHTSDVNTVCFaDESGNLILSGSDD 293
Cdd:cd00200   173 LT-----------GHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF-SPDGYLLASGSED 240

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063720767 294 NLCKVWDRRCFigrdKPAGVLVGHLEGVTFIDSRGDGRYFISNGKDQTIKLWD 346
Cdd:cd00200   241 GTIRVWDLRTG----ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
226-465 1.44e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 1.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 226 GGYSFGIFSVKFSTDGREVVAGSSDDSIYVYDLEANRVSLRTVAHTSDVNTVCFADeSGNLILSGSDDNLCKVWDrrcfI 305
Cdd:COG2319    33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWD----L 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 306 GRDKPAGVLVGHLEGVTFIDSRGDGRYFISNGKDQTIKLWDIRKmsssaparhevlrnyewdyrwmdypteardlkhplD 385
Cdd:COG2319   108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT-----------------------------------G 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 386 QSVSTYKGHSVLRTLIRcyFSPahsTGqKYIYTGSNDSSVYIYDLVSGDKVAVLKHHSSPVRDCNWHPYYPTLISSSWDG 465
Cdd:COG2319   153 KLLRTLTGHSGAVTSVA--FSP---DG-KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADG 226
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 312-473 1.15e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.21  E-value: 1.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 312 GVLVGHLEGVTFIDSRGDGRYFISNGKDQTIKLWDIRKmsssaparhevlrnyewdyrwmdypteardlkhplDQSVSTY 391
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET-----------------------------------GELLRTL 47

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 392 KGHSVLRTLIRCYfspAHSTgqkYIYTGSNDSSVYIYDLVSGDKVAVLKHHSSPVRDCNWHPYYPTLISSSWDGDLVKWE 471
Cdd:cd00200    48 KGHTGPVRDVAAS---ADGT---YLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121


                  ..
gi 1063720767 472 FP 473
Cdd:cd00200   122 VE 123
WD40 COG2319
WD40 repeat [General function prediction only];
237-471 1.89e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 1.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 237 FSTDGREVVAGSSDDSIYVYDLEANRVSLRTVAHTSDVNTVCFADESGNLILSGSDDNLCKVWDRRcfigrDKPAGVLVG 316
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAA-----GALLATLLG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 317 HLEGVTFIDSRGDGRYFISNGKDQTIKLWDIrkmSSSAPARhevlrnyewdyrwmdypteardlkhpldqsvsTYKGHSv 396
Cdd:COG2319    77 HTAAVLSVAFSPDGRLLASASADGTVRLWDL---ATGLLLR--------------------------------TLTGHT- 120

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063720767 397 lRTLIRCYFSPahstGQKYIYTGSNDSSVYIYDLVSGDKVAVLKHHSSPVRDCNWHPYYPTLISSSWDGDLVKWE 471
Cdd:COG2319   121 -GAVRSVAFSP----DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 387-470 1.13e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 1.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 387 SVSTYKGHsvlRTLIRCyfsPAHSTGQKYIYTGSNDSSVYIYDLVSGDKVAVLKHHSSPVRDCNWHPYYPTLISSSWDGD 466
Cdd:cd00200     1 LRRTLKGH---TGGVTC---VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKT 74


                  ....
gi 1063720767 467 LVKW 470
Cdd:cd00200    75 IRLW 78
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 134-428 3.72e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.86  E-value: 3.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 134 FSTDGSLFIAGFQGSRIRIYNVEKGWKVQKDI------LA-----KSLRWTvtdtslSPDQRNLVYASMSPIVHIVDVGS 202
Cdd:PLN00181  491 FDRDGEFFATAGVNKKIKIFECESIIKDGRDIhypvveLAsrsklSGICWN------SYIKSQVASSNFEGVVQVWDVAR 564

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 203 GSTeshanVTEIHDgldfssdedggYSFGIFSVKFSTDGREVVAGSSDDSIYVYDLEANRVSLRTVAHTSDVNTVCFADE 282
Cdd:PLN00181  565 SQL-----VTEMKE-----------HEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSE 628

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 283 SGNLILSGSDDNLCKVWDRRcfiGRDKPAGVLVGHLEGVTFIDSRgDGRYFISNGKDQTIKLWDirkMSSSAPARHEVlr 362
Cdd:PLN00181  629 SGRSLAFGSADHKVYYYDLR---NPKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWD---LSMSISGINET-- 699

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063720767 363 nyewdyrwmdypteardlkhPLdqsvSTYKGHSVLRTLIrcyfspAHSTGQKYIYTGSNDSSVYIY 428
Cdd:PLN00181  700 --------------------PL----HSFMGHTNVKNFV------GLSVSDGYIATGSETNEVFVY 735
COG5354 COG5354
Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];
232-392 3.76e-05

Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only];


Pssm-ID: 227657 [Multi-domain]  Cd Length: 561  Bit Score: 46.41  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 232 IFSVKFSTDGRE--VVAGSSDDSIYVYDLEANrvsLRTVAHTSDVNTVCFaDESGNLILSGSDDNL---CKVWDRRcfiG 306
Cdd:COG5354   277 VHDFTWEPLSSRfaVISGYMPASVSVFDLRGN---LRFYFPEQKRNTIFF-SPHERYILFAGFDNLqgnIEIFDPA---G 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063720767 307 RDKPAGVLVGhlEGVTFIDSRGDGRYFISN------GKDQTIKLWDIrkmsssAPARHEVLRNYEWDYRWMDYPTEARDL 380
Cdd:COG5354   350 RFKVAGAFNG--LNTSYCDWSPDGQFYDTDttseklRVDNSIKLWDV------YGAKVFELTNITWDPSGQYVTTSSSCP 421

                         170
                  ....*....|..
gi 1063720767 381 KHPLDQSVSTYK 392
Cdd:COG5354   422 KHKVEHGYKIFK 433
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 432-471 1.16e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.16e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1063720767  432 SGDKVAVLKHHSSPVRDCNWHPYYPTLISSSWDGDLVKWE 471
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 269-300 1.67e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.67e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1063720767  269 AHTSDVNTVCFaDESGNLILSGSDDNLCKVWD 300
Cdd:smart00320  10 GHTGPVTSVAF-SPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
269-300 3.77e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.77e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1063720767 269 AHTSDVNTVCFaDESGNLILSGSDDNLCKVWD 300
Cdd:pfam00400   9 GHTGSVTSLAF-SPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
309-346 6.22e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 6.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1063720767 309 KPAGVLVGHLEGVTFIDSRGDGRYFISNGKDQTIKLWD 346
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
433-471 1.04e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.04e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1063720767 433 GDKVAVLKHHSSPVRDCNWHPYYPTLISSSWDGDLVKWE 471
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 309-346 1.49e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.49e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1063720767  309 KPAGVLVGHLEGVTFIDSRGDGRYFISNGKDQTIKLWD 346
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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