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Conserved domains on  [gi|1063725135|ref|NP_001328286|]
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S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

Protein Classification

NOL1/NOP2/SUN domain family protein( domain architecture ID 1003105)

NOL1/NOP2/SUN domain (NSUN) family protein such as mammalian nucleolar protein NOP2 which is required for nucleolar maturation and ribosome biogenesis

Gene Ontology:  GO:0003723|GO:0000027|GO:0008173|GO:0001510

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
nop2p super family cl33194
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 270-532 2.06e-92

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


The actual alignment was detected with superfamily member TIGR00446:

Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 283.20  E-value: 2.06e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 270 IRTNTLKTRRRDLADILLNRGVNLDPLSKWSKVGliVYDSQVPIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDM 349
Cdd:TIGR00446   1 IRVNTLKINVEDLLERLENRGVVLEPTCEEYFFE--VKESPFSIGSTPEYLFGYYYPQEASSMIPPIALEPREDERVLDM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 350 AAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRMGVTNTIVCNYDGRELTKVLGQssVDRVLLDAPCSGTGVI 429
Cdd:TIGR00446  79 AAAPGGKTTQISQLMKNKGCIVANEISKSRTKALISNINRMGVLNTIVINADGRKFGAYLLK--FDAILLDAPCSGEGVI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 430 SKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTGGYIVYSTCSVMIPEvgepyffcstiffswhlhvfslvlfv 509
Cdd:TIGR00446 157 RKDPSRKRNWSEEDIKYCSLLQKELIDAAIDAL----KPGGVLVYSTCSLEVEE-------------------------- 206

                         250       260
                  ....*....|....*....|....
gi 1063725135 510 qqimqNEAVIDYALKNR-DVKLVP 532
Cdd:TIGR00446 207 -----NEEVIDYILRKRpDVVEEI 225
 
Name Accession Description Interval E-value
nop2p TIGR00446
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 270-532 2.06e-92

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 283.20  E-value: 2.06e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 270 IRTNTLKTRRRDLADILLNRGVNLDPLSKWSKVGliVYDSQVPIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDM 349
Cdd:TIGR00446   1 IRVNTLKINVEDLLERLENRGVVLEPTCEEYFFE--VKESPFSIGSTPEYLFGYYYPQEASSMIPPIALEPREDERVLDM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 350 AAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRMGVTNTIVCNYDGRELTKVLGQssVDRVLLDAPCSGTGVI 429
Cdd:TIGR00446  79 AAAPGGKTTQISQLMKNKGCIVANEISKSRTKALISNINRMGVLNTIVINADGRKFGAYLLK--FDAILLDAPCSGEGVI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 430 SKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTGGYIVYSTCSVMIPEvgepyffcstiffswhlhvfslvlfv 509
Cdd:TIGR00446 157 RKDPSRKRNWSEEDIKYCSLLQKELIDAAIDAL----KPGGVLVYSTCSLEVEE-------------------------- 206

                         250       260
                  ....*....|....*....|....
gi 1063725135 510 qqimqNEAVIDYALKNR-DVKLVP 532
Cdd:TIGR00446 207 -----NEEVIDYILRKRpDVVEEI 225
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
 230-540 3.97e-74

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 241.84  E-value: 3.97e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 230 ADLSSYYGYNEFLIGTLIEMFPVVELMELIEAFEKKRPTSIRTNTLKTRRRDLADILLNRGVNLDPlSKWSKVGLIVyDS 309
Cdd:COG0144   139 ERLAVRYSHPEWLVERLRAAYGPEEAEALLAALNEPPPLDLRVNTLKASREELLARLAEEGIEAEP-TPLSPDGLRL-EG 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 310 QVPIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDMAAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHR 389
Cdd:COG0144   217 PGPVTALPGFREGLFSVQDEASQLVALLLDPKPGERVLDLCAAPGGKTLHLAELMGNKGRVVAVDISEHRLKRLRENLAR 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 390 MGVTNTIVCNYDGRELTKVLGQsSVDRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTG 469
Cdd:COG0144   297 LGLSNVEVVVADARELLEWLPG-KFDRVLLDAPCSGTGTLRRHPDIKWRRTPEDIAELAALQRELLDAAARLL----KPG 371

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063725135 470 GYIVYSTCSVMiPEvgEpyffcstiffswhlhvfslvlfvqqimqNEAVIDYALKNR-DVKLVPCGLDFGRP 540
Cdd:COG0144   372 GRLVYSTCSLL-PE--E----------------------------NEEVVEAFLARHpDFELVPLAELLPGL 412
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
 335-532 7.71e-68

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 217.29  E-value: 7.71e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 335 VMALAPREKERVVDMAAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRMGVTNTIVCNYDGRELTKVLGQSSV 414
Cdd:pfam01189   1 AILLAPQEGETILDMCAAPGGKTTHIAELMKNQGTVVAVDINKHRLKRVAENIHRLGVTNTIILNGDGRQPDQWLGGVLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 415 DRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTGGYIVYSTCSVMIPEvgepyffcsti 494
Cdd:pfam01189  81 DRILLDAPCSGTGVIRRHPDVKWLRQEADIAQLAQLQKELLSAAIDLL----KPGGVLVYSTCSVLPEE----------- 145

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1063725135 495 ffswhlhvfslvlfvqqimqNEAVIDYALKNR-DVKLVP 532
Cdd:pfam01189 146 --------------------NEAVIEYFLQKHpDVELVP 164
yebU PRK11933
rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed
 269-477 1.27e-54

rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed


Pssm-ID: 183387 [Multi-domain]  Cd Length: 470  Bit Score: 191.27  E-value: 1.27e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 269 SIRTNTLKTRRRDLADILLNRGVNLDPLSkWSKVGL-IVYD--SQVPIGATPEYLAGFYMLQSASSFLPVMAL--APREK 343
Cdd:PRK11933   36 SIRVNTLKISVADFLQLMAPYGWTLTPIP-WCEEGFwIERDdeDALPLGNTAEHLSGLFYIQEASSMLPVAALfaDDNAP 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 344 ERVVDMAAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRMGVTNTIVCNYDGReltkVLGQ---SSVDRVLLD 420
Cdd:PRK11933  115 QRVLDMAAAPGSKTTQIAALMNNQGAIVANEYSASRVKVLHANISRCGVSNVALTHFDGR----VFGAalpETFDAILLD 190

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063725135 421 APCSGTGVISKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTGGYIVYSTC 477
Cdd:PRK11933  191 APCSGEGTVRKDPDALKNWSPESNLEIAATQRELIESAFHAL----KPGGTLVYSTC 243
 
Name Accession Description Interval E-value
nop2p TIGR00446
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 270-532 2.06e-92

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 283.20  E-value: 2.06e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 270 IRTNTLKTRRRDLADILLNRGVNLDPLSKWSKVGliVYDSQVPIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDM 349
Cdd:TIGR00446   1 IRVNTLKINVEDLLERLENRGVVLEPTCEEYFFE--VKESPFSIGSTPEYLFGYYYPQEASSMIPPIALEPREDERVLDM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 350 AAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRMGVTNTIVCNYDGRELTKVLGQssVDRVLLDAPCSGTGVI 429
Cdd:TIGR00446  79 AAAPGGKTTQISQLMKNKGCIVANEISKSRTKALISNINRMGVLNTIVINADGRKFGAYLLK--FDAILLDAPCSGEGVI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 430 SKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTGGYIVYSTCSVMIPEvgepyffcstiffswhlhvfslvlfv 509
Cdd:TIGR00446 157 RKDPSRKRNWSEEDIKYCSLLQKELIDAAIDAL----KPGGVLVYSTCSLEVEE-------------------------- 206

                         250       260
                  ....*....|....*....|....
gi 1063725135 510 qqimqNEAVIDYALKNR-DVKLVP 532
Cdd:TIGR00446 207 -----NEEVIDYILRKRpDVVEEI 225
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
 230-540 3.97e-74

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 241.84  E-value: 3.97e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 230 ADLSSYYGYNEFLIGTLIEMFPVVELMELIEAFEKKRPTSIRTNTLKTRRRDLADILLNRGVNLDPlSKWSKVGLIVyDS 309
Cdd:COG0144   139 ERLAVRYSHPEWLVERLRAAYGPEEAEALLAALNEPPPLDLRVNTLKASREELLARLAEEGIEAEP-TPLSPDGLRL-EG 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 310 QVPIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDMAAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHR 389
Cdd:COG0144   217 PGPVTALPGFREGLFSVQDEASQLVALLLDPKPGERVLDLCAAPGGKTLHLAELMGNKGRVVAVDISEHRLKRLRENLAR 296

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 390 MGVTNTIVCNYDGRELTKVLGQsSVDRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTG 469
Cdd:COG0144   297 LGLSNVEVVVADARELLEWLPG-KFDRVLLDAPCSGTGTLRRHPDIKWRRTPEDIAELAALQRELLDAAARLL----KPG 371

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063725135 470 GYIVYSTCSVMiPEvgEpyffcstiffswhlhvfslvlfvqqimqNEAVIDYALKNR-DVKLVPCGLDFGRP 540
Cdd:COG0144   372 GRLVYSTCSLL-PE--E----------------------------NEEVVEAFLARHpDFELVPLAELLPGL 412
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
 335-532 7.71e-68

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 217.29  E-value: 7.71e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 335 VMALAPREKERVVDMAAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRMGVTNTIVCNYDGRELTKVLGQSSV 414
Cdd:pfam01189   1 AILLAPQEGETILDMCAAPGGKTTHIAELMKNQGTVVAVDINKHRLKRVAENIHRLGVTNTIILNGDGRQPDQWLGGVLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 415 DRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTGGYIVYSTCSVMIPEvgepyffcsti 494
Cdd:pfam01189  81 DRILLDAPCSGTGVIRRHPDVKWLRQEADIAQLAQLQKELLSAAIDLL----KPGGVLVYSTCSVLPEE----------- 145

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1063725135 495 ffswhlhvfslvlfvqqimqNEAVIDYALKNR-DVKLVP 532
Cdd:pfam01189 146 --------------------NEAVIEYFLQKHpDVELVP 164
yebU PRK11933
rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed
 269-477 1.27e-54

rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed


Pssm-ID: 183387 [Multi-domain]  Cd Length: 470  Bit Score: 191.27  E-value: 1.27e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 269 SIRTNTLKTRRRDLADILLNRGVNLDPLSkWSKVGL-IVYD--SQVPIGATPEYLAGFYMLQSASSFLPVMAL--APREK 343
Cdd:PRK11933   36 SIRVNTLKISVADFLQLMAPYGWTLTPIP-WCEEGFwIERDdeDALPLGNTAEHLSGLFYIQEASSMLPVAALfaDDNAP 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 344 ERVVDMAAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRMGVTNTIVCNYDGReltkVLGQ---SSVDRVLLD 420
Cdd:PRK11933  115 QRVLDMAAAPGSKTTQIAALMNNQGAIVANEYSASRVKVLHANISRCGVSNVALTHFDGR----VFGAalpETFDAILLD 190

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063725135 421 APCSGTGVISKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTGGYIVYSTC 477
Cdd:PRK11933  191 APCSGEGTVRKDPDALKNWSPESNLEIAATQRELIESAFHAL----KPGGTLVYSTC 243
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
200-479 1.28e-49

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 176.91  E-value: 1.28e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 200 REIVRilSNFKDLKPKGDKHERndyvgqlkadLSSYYGYNEFLIGTLIEMFPVVELMELIEAFEKKRPTSIRTNTLKTRR 279
Cdd:PRK14902  123 RNILR--EGLPDIDEIKDPVKR----------LSIKYSHPVWLVKRWIDQYGEEKAEKILESLNEPPKASIRVNTLKISV 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 280 RDLADILLNRGVNLDPlSKWSKVGLIVydSQVPIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDMAAAPGGKTTY 359
Cdd:PRK14902  191 EELIEKLEEEGYEVEE-SLLSPEALVI--EKGNIAGTDLFKDGLITIQDESSMLVAPALDPKGGDTVLDACAAPGGKTTH 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 360 VAALMKNTGIIYANEMKVPRLKSLSANLHRMGVTNTIVCNYDGRELTKVLGQSSvDRVLLDAPCSGTGVISKDESVKTSK 439
Cdd:PRK14902  268 IAELLKNTGKVVALDIHEHKLKLIEENAKRLGLTNIETKALDARKVHEKFAEKF-DKILVDAPCSGLGVIRRKPDIKYNK 346

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1063725135 440 SADDIKKFAHLQKQLILGAIDLVdansKTGGYIVYSTCSV 479
Cdd:PRK14902  347 TKEDIESLQEIQLEILESVAQYL----KKGGILVYSTCTI 382
PRK14901 PRK14901
16S rRNA methyltransferase B; Provisional
 232-479 1.68e-42

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237856 [Multi-domain]  Cd Length: 434  Bit Score: 157.40  E-value: 1.68e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 232 LSSYYGYNEFLIGTLIEMFPVVELMELIEAFEKKRPTSIRTNTLKTRRRDLADILLNRGVNLDPLSKWSKvGLIVYDSQV 311
Cdd:PRK14901  143 LAILHSFPDWLVKLWLEWLGLEEAEQLCKWFNQPPSLDLRINPLRTSLEEVQAALAEAGITATPIPGLPQ-GLRLTGNPG 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 312 PIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDMAAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRMG 391
Cdd:PRK14901  222 SIRQLPGYEEGWWTVQDRSAQLVAPLLDPQPGEVILDACAAPGGKTTHIAELMGDQGEIWAVDRSASRLKKLQENAQRLG 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 392 VTNTIVCNYDGRELTKVLGQ--SSVDRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTG 469
Cdd:PRK14901  302 LKSIKILAADSRNLLELKPQwrGYFDRILLDAPCSGLGTLHRHPDARWRQTPEKIQELAPLQAELLESLAPLL----KPG 377

                         250
                  ....*....|
gi 1063725135 470 GYIVYSTCSV 479
Cdd:PRK14901  378 GTLVYATCTL 387
rsmB TIGR00563
16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. ...
 236-483 5.44e-38

16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. The reading frame was originally interpreted as two reading frames, fmu and fmv. The recombinant protein from E. coli was shown to methylate only C967 of small subunit (16S) ribosomal RNA and to produce only m5C at that position. The seed alignment is built from bacterial sequences only. Eukaryotic homologs include Nop2, a protein required for processing pre-rRNA, that is likely also a rRNA methyltransferase, although the fine specificity may differ. Cutoff scores are set to avoid treating archaeal and eukaroytic homologs automatically as functionally equivalent, although they may have very similar roles. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273141 [Multi-domain]  Cd Length: 426  Bit Score: 144.63  E-value: 5.44e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 236 YGYNEFLIGTLIEMFPVVElMELIEAFEKKRPTSIRTNTLKTRRRDLADILLNRGVNLDPLSKWSKVglIVYDSQVPIGA 315
Cdd:TIGR00563 135 YLHPEWLVKRLQKAYPGQW-QSICEANNQRPPMWLRINRTKHSRDEWLALLAEAGMKGFPHDLAPDA--VRLETPAAVHA 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 316 TPEYLAGFYMLQSASSFLPVMALAPREKERVVDMAAAPGGKTTYVAALMKNtGIIYANEMKVPRLKSLSANLHRMGVTNT 395
Cdd:TIGR00563 212 LPGFEEGWVTVQDASAQWVATWLAPQNEETILDACAAPGGKTTHILELAPQ-AQVVALDIHEHRLKRVYENLKRLGLTIK 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 396 I-VCNYDGRELTKVLGQSSVDRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQlILGAI-DLVdansKTGGYIV 473
Cdd:TIGR00563 291 AeTKDGDGRGPSQWAENEQFDRILLDAPCSATGVIRRHPDIKWLRKPRDIAELAELQSE-ILDAIwPLL----KTGGTLV 365

                         250
                  ....*....|
gi 1063725135 474 YSTCSVMIPE 483
Cdd:TIGR00563 366 YATCSVLPEE 375
PRK14903 PRK14903
16S rRNA methyltransferase B; Provisional
 231-483 2.02e-31

16S rRNA methyltransferase B; Provisional


Pssm-ID: 184896 [Multi-domain]  Cd Length: 431  Bit Score: 126.14  E-value: 2.02e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 231 DLSSYYGYNEFLIGTLIEMFPVVELMELIEAFEKKRPTSIRTNTLKTRRRDLADILLNRGVNLDPlSKWSKVGLIVYDSQ 310
Cdd:PRK14903  127 ELHLKYSHPKWLVNYWRSFLPEEAVLRIMEWNQEPLPTMLRVNSLAITREEVIKILAEEGTEAVP-GKHSPFSLIVRKLG 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 311 VPIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDMAAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRM 390
Cdd:PRK14903  206 VNMNDSRVIKDGLATVQGESSQIVPLLMELEPGLRVLDTCAAPGGKTTAIAELMKDQGKILAVDISREKIQLVEKHAKRL 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 391 GVTNTIVCNYDGRELTKVLgQSSVDRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQLILGAIDLVdansKTGG 470
Cdd:PRK14903  286 KLSSIEIKIADAERLTEYV-QDTFDRILVDAPCTSLGTARNHPEVLRRVNKEDFKKLSEIQLRIVSQAWKLL----EKGG 360

                         250
                  ....*....|...
gi 1063725135 471 YIVYSTCSVMIPE 483
Cdd:PRK14903  361 ILLYSTCTVTKEE 373
PRK10901 PRK10901
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
220-486 1.21e-24

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 236790 [Multi-domain]  Cd Length: 427  Bit Score: 106.43  E-value: 1.21e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 220 ERNDYVGQLKADLSSYYGYNEFLIGTLIEMFPVvELMELIEAFEKKRPTSIRTNTLKTRRRDLADILLNRGVNLDPlSKW 299
Cdd:PRK10901  125 EQEELLAELQADPVARYNHPSWLIKRLKKAYPE-QWQAILAANNQRPPMWLRVNRRHHSRDAYLALLAEAGIEAFP-HAV 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 300 SKVGlIVYDSQVPIGATPEYLAGFYMLQSASSFLPVMALAPREKERVVDMAAAPGGKTTYVAALMKNTGIIyANEMKVPR 379
Cdd:PRK10901  203 GPDA-IRLETPVPVHQLPGFAEGWVSVQDAAAQLAATLLAPQNGERVLDACAAPGGKTAHILELAPQAQVV-ALDIDAQR 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 380 LKSLSANLHRMGVTNTIVCNyDGRELTKVLGQSSVDRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQLIlgai 459
Cdd:PRK10901  281 LERVRENLQRLGLKATVIVG-DARDPAQWWDGQPFDRILLDAPCSATGVIRRHPDIKWLRRPEDIAALAALQSEIL---- 355

                         250       260       270
                  ....*....|....*....|....*....|
gi 1063725135 460 dlvDA---NSKTGGYIVYSTCSVMiPEVGE 486
Cdd:PRK10901  356 ---DAlwpLLKPGGTLLYATCSIL-PEENE 381
PRK14904 PRK14904
16S rRNA methyltransferase B; Provisional
 327-479 1.97e-24

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237858 [Multi-domain]  Cd Length: 445  Bit Score: 105.91  E-value: 1.97e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063725135 327 QSASSFLPVMALAPREKERVVDMAAAPGGKTTYVAALMKNTGIIYANEMKVPRLKSLSANLHRMGVtnTIVCNYDGRELT 406
Cdd:PRK14904  235 QNPTQALACLLLNPQPGSTVLDLCAAPGGKSTFMAELMQNRGQITAVDRYPQKLEKIRSHASALGI--TIIETIEGDARS 312

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063725135 407 KVLGQsSVDRVLLDAPCSGTGVISKDESVKTSKSADDIKKFAHLQKQLILGAIDLVDAnsktGGYIVYSTCSV 479
Cdd:PRK14904  313 FSPEE-QPDAILLDAPCTGTGVLGRRAELRWKLTPEKLAELVGLQAELLDHAASLLKP----GGVLVYATCSI 380
Methyltr_RsmF_N pfam17125
N-terminal domain of 16S rRNA methyltransferase RsmF; This is the N-terminal domain of the ...
 257-331 1.15e-10

N-terminal domain of 16S rRNA methyltransferase RsmF; This is the N-terminal domain of the RsmF methyl transferase. RsmF is a multi-site-specific methyltransferase that is responsible for the synthesis of three modifications on cytidines in 16S ribosomal RNA. The N-terminus is critical for stabilising the catalytic core of the enzyme.


Pssm-ID: 465356 [Multi-domain]  Cd Length: 88  Bit Score: 57.87  E-value: 1.15e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063725135 257 ELIEAFEKKRPTSIRTNTLKTRRRDLADILLNRgvnLDPLSkWSKVGLIVYDSQVPiGATPEYLAGFYMLQSASS 331
Cdd:pfam17125  19 AFLAAYDEPRPVGLRVNTLKISVEEFLKLSPFE---LEPVP-WCEEGFYLEERPRP-GKHPYHHAGLYYIQEPSA 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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