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Conserved domains on  [gi|1063709590|ref|NP_001327824|]
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O-fucosyltransferase family protein [Arabidopsis thaliana]

Protein Classification

O-fucosyltransferase family protein( domain architecture ID 10181896)

O-fucosyltransferase family protein may be involved in glycan metabolism by O-fucosylation of protein substrates

Gene Ontology:  GO:0006004|GO:0016757
PubMed:  12966037|12868606

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
O-FucT_like cd11296
GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like ...
69-384 5.90e-24

GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.


:

Pssm-ID: 211383  Cd Length: 206  Bit Score: 99.03  E-value: 5.90e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590  69 FLEVPQIVWGLNNQKIAFARACLTARMMNRTLLMPslsaslfykevdklrpipfdkvfqferfnslcsgfvrlsrfsdvk 148
Cdd:cd11296     1 YLLPIPDGGGFNNQRNEFLNALLLAILLGRTLVLP--------------------------------------------- 35
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 149 nraqvfdlekgsgrrwtverdlehlkqsarnesIDEFEVIRLIGKnpflwHDHWPvedyakvfecmvvvDEISREADKVV 228
Cdd:cd11296    36 ---------------------------------LCLACPIRLVGK-----HLRFS--------------PEIRKLADRFV 63
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 229 MKIREageaeraklaskteiLGPVPFVAVHMRIEIDWMIHCKK-LEQRKKISEICSSKREILDRVGNISGLKTPTVLYLA 307
Cdd:cd11296    64 RKLLG---------------LPGGPYLAVHLRRGDFEVECCHLaKWMGEYLEECLLSAEEIAEKIKELMAERKLKVVYVA 128
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 308 ----VADTLLEEKEEDSSVLSGWRDgLIPFEKKKLGVKEEIYgkysylIQSAIDYEVCLRADVFVGNSFSTFSSLIVLER 383
Cdd:cd11296   129 tdeaDREELREELRKAGIRVVTKDD-LLEDAELLELEKLDNY------LLSLVDQEICSRADVFIGTGFSTFSSNVALLR 201

                  .
gi 1063709590 384 T 384
Cdd:cd11296   202 R 202
 
Name Accession Description Interval E-value
O-FucT_like cd11296
GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like ...
69-384 5.90e-24

GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.


Pssm-ID: 211383  Cd Length: 206  Bit Score: 99.03  E-value: 5.90e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590  69 FLEVPQIVWGLNNQKIAFARACLTARMMNRTLLMPslsaslfykevdklrpipfdkvfqferfnslcsgfvrlsrfsdvk 148
Cdd:cd11296     1 YLLPIPDGGGFNNQRNEFLNALLLAILLGRTLVLP--------------------------------------------- 35
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 149 nraqvfdlekgsgrrwtverdlehlkqsarnesIDEFEVIRLIGKnpflwHDHWPvedyakvfecmvvvDEISREADKVV 228
Cdd:cd11296    36 ---------------------------------LCLACPIRLVGK-----HLRFS--------------PEIRKLADRFV 63
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 229 MKIREageaeraklaskteiLGPVPFVAVHMRIEIDWMIHCKK-LEQRKKISEICSSKREILDRVGNISGLKTPTVLYLA 307
Cdd:cd11296    64 RKLLG---------------LPGGPYLAVHLRRGDFEVECCHLaKWMGEYLEECLLSAEEIAEKIKELMAERKLKVVYVA 128
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 308 ----VADTLLEEKEEDSSVLSGWRDgLIPFEKKKLGVKEEIYgkysylIQSAIDYEVCLRADVFVGNSFSTFSSLIVLER 383
Cdd:cd11296   129 tdeaDREELREELRKAGIRVVTKDD-LLEDAELLELEKLDNY------LLSLVDQEICSRADVFIGTGFSTFSSNVALLR 201

                  .
gi 1063709590 384 T 384
Cdd:cd11296   202 R 202
O-FucT pfam10250
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing ...
78-384 3.46e-19

GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteriztic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese.


Pssm-ID: 463023 [Multi-domain]  Cd Length: 247  Bit Score: 86.58  E-value: 3.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590  78 GLNNQKIAFARACLTARMMNRTLLMPSLSASLFYKEvDKLRPIPFDKVFQfERFNSLCsgfvrlsrfsdvknraqvfdle 157
Cdd:pfam10250  10 GFNQQRDHICDAVAFARLLNATLVLPPWDQLYHWRD-PSTDQIPFSDIFD-EFIESLC---------------------- 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 158 kgsgrrwtverdleHLKQsarnesidefevirliGKNPFLWhDHwpvedyakvFECMVVVDEISREADKVVMKIReagea 237
Cdd:pfam10250  66 --------------RSKQ----------------GNFGPFW-VN---------FHALRFSPEIEELGDKLVDRLL----- 100
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 238 eraklaskteilgPVPFVAVHMRIEIDWMIHCKKLE--QRKKISEICSSKR-----------------EILDRVGNIsgL 298
Cdd:pfam10250 101 -------------KGPYLALHLRREKDMLAASGCAEggGDEEAEEDPEERRrnglcpltpeeclpslvGILLQALGF--V 165
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 299 KTPTVLYLAvADtlleeKEEDSSVLSGWRDGLIPFEKKK-LGVKEEIYGKYSYLIQsAIDYEVCLRADVFVGNSFSTFSS 377
Cdd:pfam10250 166 KKLTRIYVA-TD-----EIYGGEELAPLKSMFPNLVTKEsLASVEELEPFKDGSSA-ALDYIICLHSDVFIGTCVSNFSA 238

                  ....*..
gi 1063709590 378 LIVLERT 384
Cdd:pfam10250 239 FVKGERR 245
 
Name Accession Description Interval E-value
O-FucT_like cd11296
GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like ...
69-384 5.90e-24

GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.


Pssm-ID: 211383  Cd Length: 206  Bit Score: 99.03  E-value: 5.90e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590  69 FLEVPQIVWGLNNQKIAFARACLTARMMNRTLLMPslsaslfykevdklrpipfdkvfqferfnslcsgfvrlsrfsdvk 148
Cdd:cd11296     1 YLLPIPDGGGFNNQRNEFLNALLLAILLGRTLVLP--------------------------------------------- 35
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 149 nraqvfdlekgsgrrwtverdlehlkqsarnesIDEFEVIRLIGKnpflwHDHWPvedyakvfecmvvvDEISREADKVV 228
Cdd:cd11296    36 ---------------------------------LCLACPIRLVGK-----HLRFS--------------PEIRKLADRFV 63
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 229 MKIREageaeraklaskteiLGPVPFVAVHMRIEIDWMIHCKK-LEQRKKISEICSSKREILDRVGNISGLKTPTVLYLA 307
Cdd:cd11296    64 RKLLG---------------LPGGPYLAVHLRRGDFEVECCHLaKWMGEYLEECLLSAEEIAEKIKELMAERKLKVVYVA 128
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 308 ----VADTLLEEKEEDSSVLSGWRDgLIPFEKKKLGVKEEIYgkysylIQSAIDYEVCLRADVFVGNSFSTFSSLIVLER 383
Cdd:cd11296   129 tdeaDREELREELRKAGIRVVTKDD-LLEDAELLELEKLDNY------LLSLVDQEICSRADVFIGTGFSTFSSNVALLR 201

                  .
gi 1063709590 384 T 384
Cdd:cd11296   202 R 202
O-FucT pfam10250
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing ...
78-384 3.46e-19

GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteriztic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese.


Pssm-ID: 463023 [Multi-domain]  Cd Length: 247  Bit Score: 86.58  E-value: 3.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590  78 GLNNQKIAFARACLTARMMNRTLLMPSLSASLFYKEvDKLRPIPFDKVFQfERFNSLCsgfvrlsrfsdvknraqvfdle 157
Cdd:pfam10250  10 GFNQQRDHICDAVAFARLLNATLVLPPWDQLYHWRD-PSTDQIPFSDIFD-EFIESLC---------------------- 65
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 158 kgsgrrwtverdleHLKQsarnesidefevirliGKNPFLWhDHwpvedyakvFECMVVVDEISREADKVVMKIReagea 237
Cdd:pfam10250  66 --------------RSKQ----------------GNFGPFW-VN---------FHALRFSPEIEELGDKLVDRLL----- 100
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 238 eraklaskteilgPVPFVAVHMRIEIDWMIHCKKLE--QRKKISEICSSKR-----------------EILDRVGNIsgL 298
Cdd:pfam10250 101 -------------KGPYLALHLRREKDMLAASGCAEggGDEEAEEDPEERRrnglcpltpeeclpslvGILLQALGF--V 165
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 299 KTPTVLYLAvADtlleeKEEDSSVLSGWRDGLIPFEKKK-LGVKEEIYGKYSYLIQsAIDYEVCLRADVFVGNSFSTFSS 377
Cdd:pfam10250 166 KKLTRIYVA-TD-----EIYGGEELAPLKSMFPNLVTKEsLASVEELEPFKDGSSA-ALDYIICLHSDVFIGTCVSNFSA 238

                  ....*..
gi 1063709590 378 LIVLERT 384
Cdd:pfam10250 239 FVKGERR 245
O-FucT_plant cd11299
GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this ...
78-384 2.60e-15

GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.


Pssm-ID: 211385  Cd Length: 290  Bit Score: 76.06  E-value: 2.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590  78 GLNNQKIAFARACLTARMMNRTLLMPSLSASLFYKEVDKlrpipFDKVFQFERF-NSLcSGFVRL-----SRFSDVKNRA 151
Cdd:cd11299     9 GLNQQRSQICDAVAVARLLNATLVLPELDKNSVWGDSSK-----FGDIYDVDHFiKSL-KDDVRVvkklpEELASKKPEI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 152 QVFDLEKGSGRRWTVERDLEHLKQSarnesidefEVIRLIGKNPFLWHDHWPVEdyAKVFECMV------VVDEISREAD 225
Cdd:cd11299    83 TVKRVPSRSSPSYYLEEVLPLLKKH---------GVIRLAPFDSRLANDLLPPE--IQRLRCRVnfhalrFVPEIEELGD 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 226 KVVMKIREAGEaeraklaskteilgpvPFVAVHMRIEIDwMI---HCKKLeqrkkiseiCSSKREildrVGNI---SGLK 299
Cdd:cd11299   152 KLVDRLREAGG----------------PFLALHLRFEKD-MLafsGCGKC---------PLTPEE----VGLLlraLGFP 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063709590 300 TPTVLYLAvadtlleekeedSSVLSGWRDGLIP--------FEKKKLGVKEEI--YGKYSyLIQSAIDYEVCLRADVFVG 369
Cdd:cd11299   202 RSTRIYLA------------AGEIYGGERRLDPlrsifpnlYTKETLATAEELapFSGHS-SRLAALDYIVCLESDVFVP 268
                         330
                  ....*....|....*
gi 1063709590 370 NSFSTFSSLIVLERT 384
Cdd:cd11299   269 TYGGNFAKAVAGHRR 283
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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