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Conserved domains on  [gi|1063704497|ref|NP_001324703|]
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Major facilitator superfamily protein [Arabidopsis thaliana]

Protein Classification

spinster family MFS transporter( domain architecture ID 13023647)

spinster family major facilitator superfamily (MFS) transporter may function as a sphingolipid transporter that plays a central role in endosome and/or lysosome storage

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0006869
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1.49

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 52-476 3.48e-90

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 281.43  E-value: 3.48e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  52 LVIFCIINLLNYMDRGAIASNGVNgstrscndkgkctlatgIQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLAKR--- 128
Cdd:cd17328     1 VAVLFLINLLNYMDRFTIAGVLPD-----------------IQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRynr 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 129 --LIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYG 206
Cdd:cd17328    64 kwILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVG 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 207 GYVGKHF-SWRYAFWGEAVLMAPFAVL-GFLMKPLQLKGSETLKNNNrlqvdneiehdqfevsietskssyanavfKSFT 284
Cdd:cd17328   144 GLVAQATgGWRWAFRVTGVLGVLLAILlLLFVREPPRGAAEGGVMAK-----------------------------STAT 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 285 GFAKDMKVLYKEKVFVVNVLGYVSYNFVIGAYSYWGPKAGYNIYKMK-----NADMIFGAVTIICGIVGTLSGGFILDRV 359
Cdd:cd17328   195 SFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGdlssaDVGLIFGAITCIAGVLGVLLGGILADRL 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 360 TATIPNAFKLLSGATFLGAVFCFTA---FTLKSLYGFIALFALGELLVFATQAPVNYVCLHCVKPSLRPLSMAISTVAIH 436
Cdd:cd17328   275 RRKTPRADPLVCAVGLLAAAPFLFLalvLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSH 354

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063704497 437 IFGDVPSSPLVGIVQDHIN-----------SWRKTTLILTSILFLAAAIWF 476
Cdd:cd17328   355 LLGDAGSPYLIGLISDLLRqnkdsplaeaaSLQYALLLCSFVLVLGGFFFL 405
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 52-476 3.48e-90

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 281.43  E-value: 3.48e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  52 LVIFCIINLLNYMDRGAIASNGVNgstrscndkgkctlatgIQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLAKR--- 128
Cdd:cd17328     1 VAVLFLINLLNYMDRFTIAGVLPD-----------------IQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRynr 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 129 --LIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYG 206
Cdd:cd17328    64 kwILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVG 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 207 GYVGKHF-SWRYAFWGEAVLMAPFAVL-GFLMKPLQLKGSETLKNNNrlqvdneiehdqfevsietskssyanavfKSFT 284
Cdd:cd17328   144 GLVAQATgGWRWAFRVTGVLGVLLAILlLLFVREPPRGAAEGGVMAK-----------------------------STAT 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 285 GFAKDMKVLYKEKVFVVNVLGYVSYNFVIGAYSYWGPKAGYNIYKMK-----NADMIFGAVTIICGIVGTLSGGFILDRV 359
Cdd:cd17328   195 SFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGdlssaDVGLIFGAITCIAGVLGVLLGGILADRL 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 360 TATIPNAFKLLSGATFLGAVFCFTA---FTLKSLYGFIALFALGELLVFATQAPVNYVCLHCVKPSLRPLSMAISTVAIH 436
Cdd:cd17328   275 RRKTPRADPLVCAVGLLAAAPFLFLalvLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSH 354

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063704497 437 IFGDVPSSPLVGIVQDHIN-----------SWRKTTLILTSILFLAAAIWF 476
Cdd:cd17328   355 LLGDAGSPYLIGLISDLLRqnkdsplaeaaSLQYALLLCSFVLVLGGFFFL 405
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
50-477 7.93e-30

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 119.97  E-value: 7.93e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  50 WLLVIFCIINLLNYMDRGAIAsngvngstrscndkgkcTLATGIQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLA--- 126
Cdd:COG2271    10 RILALLFLAYFLNYLDRSNLS-----------------VAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLAdrf 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 127 --KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYV 204
Cdd:COG2271    73 grRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 205 YGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLMkplqlkgsetlknnnrlqvdneiehdqfevsietskssyanavfksft 284
Cdd:COG2271   153 LLGWLLAAFGWRAAFLILGLPGLLLALLRFWL------------------------------------------------ 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 285 gfakdmkvlykekvfvvNVLGYVSYNFVIGAYSYWGPKAGYNIYKMKNADM-IFGAVTIICGIVGTLSGGFILDRVtatI 363
Cdd:COG2271   185 -----------------LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAgLLLSLPFLAGIVGSLLGGWLSDRL---G 244

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 364 PNAFKLLSGATFLGAVFCFTAFTLKSLYGFIALFALGELLVFATQAPVNYVCLHCVKPSLRPLSMAISTvAIHIFGDVPS 443
Cdd:COG2271   245 RRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVN-TFGFLGGALG 323

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1063704497 444 SPLVGIVQDHInSWRKTTLILTSILFLAAAIWFI 477
Cdd:COG2271   324 PLLVGYLLDAT-GYQAAFLLLAALALLAALLALL 356
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 50-423 3.31e-22

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 99.58  E-value: 3.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  50 WLLVIFCIINLLnymdrgAIASNGVNGSTrscndkgkctlATGIQGHFNLSNFEDGVLSSSFMVGLLIASpIFAS--LAK 127
Cdd:pfam03137   1 FFLVFLSLLGLA------QALVSGYFNSS-----------ITTIEKRFGLPSSLSGLISSSYDIGNLLLI-VFVSyfGGK 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 128 ----RLIGVGltvwtIAVLGCGS-SFA---FWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGV 199
Cdd:pfam03137  63 ghrpRWIGVG-----ALLMGLGSlLFAlphFLSFFLGQLLLGIGGTPIYTLGISYIDDNVKKKNSPLYLGILYAVRVLGP 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 200 ALGYVYGG-----YV----------GKHFSWRYAFWG----EAVLMAPFAVLgFLMKPLQLKGSETLKNNNRLQVDNEIE 260
Cdd:pfam03137 138 ALGFLLGSlclriYVdigkvsitltPKDPRWVGAWWLgfliAGLLLLLTAIP-FFFFPKSLPGAAKRRAKKKKEPHSQDI 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 261 HDQfevsietSKSSYANAVFKSFTGFAKDMKVLYKEKVFVVNVLGYVSYNFVIGAYSYWGPK---AGYNIYKMKnADMIF 337
Cdd:pfam03137 217 ADL-------KKTKSLKKLGPSLKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYATFLPKyieTQFGLSAST-ANLLT 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 338 GAVTIICGIVGTLSGGFILDRvtatipnaFKL-LSGATFLGAVFCFTaftlkSLYGFIALFALG-ELLVFATqAPVNYVC 415
Cdd:pfam03137 289 GVVAIPGAALGILLGGLIIKK--------FKLsAKGLAKFNVITSLV-----SLLLSLLLFFLGcPNSPVAG-ITVPYGG 354


                  ....*...
gi 1063704497 416 LHCVKPSL 423
Cdd:pfam03137 355 TQQLSGNL 362
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 37-413 1.47e-13

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 72.39  E-value: 1.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  37 LEIVESSSSLSPVWLLVIFC-IINLLNYMDRGAIAsngvngstrscndkgkcTLATGIQGHFNLSNFEDGVLSSSFMVGL 115
Cdd:TIGR00895   3 QNNIRKQPLSRYQWRAIILSfLIMLMDGYDLAAMG-----------------FAAPAISAEWGLDPVQLGFLFSAGLIGM 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 116 LIASPIFASLAKRLIGVGLTVWTIAVLG---CGSSFA--FWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGL 190
Cdd:TIGR00895  66 AFGALFFGPLADRIGRRRVLLWSILLFSvftLLCALAtnVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGL 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 191 FYMCIPSGVALGYVYGGYVGKHFSWRYAFWGEAVlmAPFAVLGFLMKPL-------QLKGSETLKNNNRLQVDNEIEHDQ 263
Cdd:TIGR00895 146 MFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGI--APLLLLLLLMRFLpesidflVSKRPETVRRIVNAIAPQMQAEAQ 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 264 FEVSIETSKSSYANAVFKSFtgFAKDMKvlykeKVFVVNVLGYVSYNFVIGAYSYWGPK----AGYNIYKMknadMIFGA 339
Cdd:TIGR00895 224 SALPEQKSTQGTKRSVFKAL--FQGKTA-----RITVLLWLLYFMLLVGVYFLTNWLPKlmveLGFSLSLA----ATGGA 292

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063704497 340 VTIICGIVGTLSGGFILDRVTATIPNAFKLLSGATFLGAVFCFTAFTLKSLYGFIA-LFALGELLVFATQAPVNY 413
Cdd:TIGR00895 293 LFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAgFFVNGGQSGLYALMALFY 367
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 52-476 3.48e-90

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 281.43  E-value: 3.48e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  52 LVIFCIINLLNYMDRGAIASNGVNgstrscndkgkctlatgIQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLAKR--- 128
Cdd:cd17328     1 VAVLFLINLLNYMDRFTIAGVLPD-----------------IQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRynr 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 129 --LIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYG 206
Cdd:cd17328    64 kwILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVG 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 207 GYVGKHF-SWRYAFWGEAVLMAPFAVL-GFLMKPLQLKGSETLKNNNrlqvdneiehdqfevsietskssyanavfKSFT 284
Cdd:cd17328   144 GLVAQATgGWRWAFRVTGVLGVLLAILlLLFVREPPRGAAEGGVMAK-----------------------------STAT 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 285 GFAKDMKVLYKEKVFVVNVLGYVSYNFVIGAYSYWGPKAGYNIYKMK-----NADMIFGAVTIICGIVGTLSGGFILDRV 359
Cdd:cd17328   195 SFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGdlssaDVGLIFGAITCIAGVLGVLLGGILADRL 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 360 TATIPNAFKLLSGATFLGAVFCFTA---FTLKSLYGFIALFALGELLVFATQAPVNYVCLHCVKPSLRPLSMAISTVAIH 436
Cdd:cd17328   275 RRKTPRADPLVCAVGLLAAAPFLFLalvLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSH 354

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063704497 437 IFGDVPSSPLVGIVQDHIN-----------SWRKTTLILTSILFLAAAIWF 476
Cdd:cd17328   355 LLGDAGSPYLIGLISDLLRqnkdsplaeaaSLQYALLLCSFVLVLGGFFFL 405
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
50-477 7.93e-30

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 119.97  E-value: 7.93e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  50 WLLVIFCIINLLNYMDRGAIAsngvngstrscndkgkcTLATGIQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLA--- 126
Cdd:COG2271    10 RILALLFLAYFLNYLDRSNLS-----------------VAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLAdrf 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 127 --KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYV 204
Cdd:COG2271    73 grRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPP 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 205 YGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLMkplqlkgsetlknnnrlqvdneiehdqfevsietskssyanavfksft 284
Cdd:COG2271   153 LLGWLLAAFGWRAAFLILGLPGLLLALLRFWL------------------------------------------------ 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 285 gfakdmkvlykekvfvvNVLGYVSYNFVIGAYSYWGPKAGYNIYKMKNADM-IFGAVTIICGIVGTLSGGFILDRVtatI 363
Cdd:COG2271   185 -----------------LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAgLLLSLPFLAGIVGSLLGGWLSDRL---G 244

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 364 PNAFKLLSGATFLGAVFCFTAFTLKSLYGFIALFALGELLVFATQAPVNYVCLHCVKPSLRPLSMAISTvAIHIFGDVPS 443
Cdd:COG2271   245 RRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVN-TFGFLGGALG 323

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1063704497 444 SPLVGIVQDHInSWRKTTLILTSILFLAAAIWFI 477
Cdd:COG2271   324 PLLVGYLLDAT-GYQAAFLLLAALALLAALLALL 356
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
42-442 3.35e-27

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 111.99  E-value: 3.35e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  42 SSSSLSPVWLLVIFCIINLLNYMDRGAIAsngvngstrscndkgkcTLATGIQGHFNLSNFEDGVLSSSFMVGLLIASPI 121
Cdd:COG2814     2 PATPRRRWLALLALALGAFLSGLGIGIVL-----------------PALPLIAADLGASPAQAGLVVTAYLLGAALGAPL 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 122 FASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIP 196
Cdd:COG2814    65 AGRLAdrfgrRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLG 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 197 SGVALGYVYGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLMKPlqlkgsETLKNNNRlqvdneiehdqfevsietskssya 276
Cdd:COG2814   145 LGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLP------ESRPAARA------------------------ 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 277 navfksftGFAKDMKVLYKEKVFVVNVLGYVSYNFVIGAYSYWGPKAGYNIYKMKNADM-IFGAVTIICGIVGTLSGGFI 355
Cdd:COG2814   195 --------RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAgLLLALFGLGGVLGALLAGRL 266

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 356 LDRVtatipNAFKLLSGATFLGAVFCFTAFTLKSLYGFIALFALGELLVFATQAPVNYVCLHCVKPSLRPLSMAISTVAI 435
Cdd:COG2814   267 ADRF-----GRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAF 341


                  ....*..
gi 1063704497 436 HIFGDVP 442
Cdd:COG2814   342 FLGGPLA 348
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 55-474 1.44e-22

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 99.42  E-value: 1.44e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  55 FCIINLLNYMDRGAIAsngvngstrscndkgkcTLATGIQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRL 129
Cdd:cd06174     1 LLLGFFLTGLARGLIS-----------------PLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAdrfgrRPV 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 130 IGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYV 209
Cdd:cd06174    64 LLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGIL 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 210 GKH--FSWRYAFWGEAVLMAPFAVLGFLMKPlqlkgsetlknnnrlqvdneiehdqfevsiETSKSSYANAVFKSFTGFA 287
Cdd:cd06174   144 ASSlgFGWRAVFLIAAALALLAAILLLLVVP------------------------------DPPESARAKNEEASSKSVL 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 288 KDMKVLYKEKVFVVNVLGYVSYNFVIGAYSYWGPKAGYNIYKMKNADM-IFGAVTIICGIVGTLSGGFILDRVTATIPna 366
Cdd:cd06174   194 KLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAgLLLSLFGLAGALGSLLLGLLSDRLIGRKP-- 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 367 fkLLSGATFLGAVFCFTAFTLKSLYGFIALFALGELLVFATQAPVNYVCLHCVKPSLRPLSMAISTVAIHIFGDVpSSPL 446
Cdd:cd06174   272 --LLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAI-GPLL 348

                         410       420
                  ....*....|....*....|....*...
gi 1063704497 447 VGIVQDHINSWRKTTLILTSILFLAAAI 474
Cdd:cd06174   349 AGFLLAATFGLTGAFLVLAVLLLLAAIL 376
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 50-423 3.31e-22

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 99.58  E-value: 3.31e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  50 WLLVIFCIINLLnymdrgAIASNGVNGSTrscndkgkctlATGIQGHFNLSNFEDGVLSSSFMVGLLIASpIFAS--LAK 127
Cdd:pfam03137   1 FFLVFLSLLGLA------QALVSGYFNSS-----------ITTIEKRFGLPSSLSGLISSSYDIGNLLLI-VFVSyfGGK 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 128 ----RLIGVGltvwtIAVLGCGS-SFA---FWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGV 199
Cdd:pfam03137  63 ghrpRWIGVG-----ALLMGLGSlLFAlphFLSFFLGQLLLGIGGTPIYTLGISYIDDNVKKKNSPLYLGILYAVRVLGP 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 200 ALGYVYGG-----YV----------GKHFSWRYAFWG----EAVLMAPFAVLgFLMKPLQLKGSETLKNNNRLQVDNEIE 260
Cdd:pfam03137 138 ALGFLLGSlclriYVdigkvsitltPKDPRWVGAWWLgfliAGLLLLLTAIP-FFFFPKSLPGAAKRRAKKKKEPHSQDI 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 261 HDQfevsietSKSSYANAVFKSFTGFAKDMKVLYKEKVFVVNVLGYVSYNFVIGAYSYWGPK---AGYNIYKMKnADMIF 337
Cdd:pfam03137 217 ADL-------KKTKSLKKLGPSLKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYATFLPKyieTQFGLSAST-ANLLT 288

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 338 GAVTIICGIVGTLSGGFILDRvtatipnaFKL-LSGATFLGAVFCFTaftlkSLYGFIALFALG-ELLVFATqAPVNYVC 415
Cdd:pfam03137 289 GVVAIPGAALGILLGGLIIKK--------FKLsAKGLAKFNVITSLV-----SLLLSLLLFFLGcPNSPVAG-ITVPYGG 354


                  ....*...
gi 1063704497 416 LHCVKPSL 423
Cdd:pfam03137 355 TQQLSGNL 362
MFS_1 pfam07690
Major Facilitator Superfamily;
88-437 1.94e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 95.56  E-value: 1.94e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  88 TLATGIQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGV 162
Cdd:pfam07690  18 ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSdrfgrRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 163 GEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLMKPlqlk 242
Cdd:pfam07690  98 GAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRP---- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 243 gsetlknnnrlqvdneiehdqfevsieTSKSSYANAVFKSFTGFAKDMKVLYKEKVFVVnVLGYVSYNFVIGAYSYWGPK 322
Cdd:pfam07690 174 ---------------------------PPESKRPKPAEEARLSLIVAWKALLRDPVLWL-LLALLLFGFAFFGLLTYLPL 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 323 AGyNIYKMKNADM-IFGAVTIICGIVGTLSGGFILDRVTATIPNAFkLLSGATFLGAVFCFTAFTLKSLYGFIALFALGe 401
Cdd:pfam07690 226 YQ-EVLGLSALLAgLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL-ALLLLILAALGLLLLSLTLSSLWLLLALLLLG- 302

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1063704497 402 LLVFATQAPVNYVCLHCVKPSLRPLSMAISTVAIHI 437
Cdd:pfam07690 303 FGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 96-477 4.78e-20

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 91.87  E-value: 4.78e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  96 HFNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISL 170
Cdd:cd17325    25 SLGASVAQIGLIVAAYALAQLLFSPPAGRLSdrfgrKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPA 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 171 AAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLMKPlqlkgsetlknn 250
Cdd:cd17325   105 AMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLP------------ 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 251 nrlqvdneiehdqfevsiETSKSSYANAVfkSFTGFAKDMKVLYKEKVFVVNVLGYVSYNFVIGAYSYWGPKAGYNIYKM 330
Cdd:cd17325   173 ------------------EPRPPPNKRAV--SAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 331 KNAD--MIFGAVTIICgIVGTLSGGFILDRVtatipNAFKLLSGATFLGAVFCFTAFTLKSLYGFIALFALGELLVFATQ 408
Cdd:cd17325   233 SPAQigLLFGAQGLAS-ALSQPPAGKLSDRI-----GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVF 306

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063704497 409 APVNYVCLHCVKPSLRPLSMAISTVAIHIfGDVPSSPLVGIVQDHINSwrKTTLILTSILFLAAAIWFI 477
Cdd:cd17325   307 PATLALLADIVPPEGRGTAMGLFNTAFSL-GMVLGPLLGGFLYDAFGF--ATPFLAAAALLLLAAVLFL 372
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 93-476 5.36e-20

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 91.46  E-value: 5.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  93 IQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASF 167
Cdd:cd17324    25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSdrierRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 168 ISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWGEAVLMAP-FAVLGFLMKPLQLKGSET 246
Cdd:cd17324   105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLaALLLWRLLPSLPPKKPGS 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 247 LKnnnrlqvdneiehdqfevsietskssyanaVFKSFTGFAKDMKVLYkekVFVVNVLGYVSynfVIGAYSYWGPKAGYN 326
Cdd:cd17324   185 LG------------------------------LLSSLLLLLRNPRLRL---AYLITFLLFGG---FFALYTYLAPFLTDV 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 327 IYKMKNADMIFGAVTIICGIVGTLSGGFILDRvtatIPNAFKLLSGATFLGAVFCFTAFTLKSLYGFIALFALGeLLVFA 406
Cdd:cd17324   229 PGFSSSAIIGLLLLFGVAGVVGSPLAGRLADR----GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWG-LGFFA 303

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 407 TQAPVNYVCLHCVkPSLRPLSMAISTVAIHIFGDVpSSPLVGIVQDHInSWRKTTLILTSILFLAAAIWF 476
Cdd:cd17324   304 AHSALQTRVLRLA-PEARGLASSLYLAAYNLGGAL-GAALGGLVLDHG-GWAGVGWVGAALLLLALLLAL 370
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 50-477 5.10e-19

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 88.40  E-value: 5.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  50 WLLVIFCIINLLNYMDRGAIAsngvngstrscndkgkcTLATGIQGHFNLSNFEDGVLSSSFMVGLLIASPIFASL---- 125
Cdd:cd17319     3 RIIPLLFLAYVINYLDRVNIS-----------------VAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLldrf 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 126 -AKRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYV 204
Cdd:cd17319    66 gARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPP 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 205 YGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLmkplqlkgsetlknnnrlqvdneiehdqfevsietskssyanaVFKSFT 284
Cdd:cd17319   146 LSGWLLLLFGWRWAFIIEGLLGLLLAVLWWF-------------------------------------------YLRQVW 182

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 285 GFAkdmkvlykekvfvvnvLGYVSYNFVIGAYSYWGPKAGYNIYKMKNADM-IFGAVTIICGIVGTLSGGFILDRvtaTI 363
Cdd:cd17319   183 GLA----------------LGYFGINYALYGLLTWLPTYLKQARGFSLKQVgLLAAIPFLAGAIGMILGGRLSDR---LL 243

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 364 PNAFKLLSGA-TFLGAVFCFTAFTLKSLYGFIALFALGELLVFATQAPVNYVCLHCVKPSLRPLSMAIstvaIHIFGDVP 442
Cdd:cd17319   244 RGARRLVIIIgLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGL----INSGGNLG 319

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1063704497 443 S--SPLV-GIVQDHINSWRKTTLILTSILFLAAAIWFI 477
Cdd:cd17319   320 GfvAPLLiGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 93-236 6.81e-17

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 81.01  E-value: 6.81e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  93 IQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASF 167
Cdd:COG0477    40 IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGdrygrKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGL 119

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063704497 168 ISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWgeavLMAPFAVLGFLM 236
Cdd:COG0477   120 MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFL----INAPLGLLALVL 184
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
50-480 1.87e-14

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 74.92  E-value: 1.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  50 WLLVIFCIINLLNYMDRGAIAsngvngstrscndkgkcTLATGIQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLA--- 126
Cdd:COG2223     5 RVLLLATLAFFLAFGVWYLWS-----------------VLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVdrf 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 127 --KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYV 204
Cdd:COG2223    68 gpRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAF 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 205 YGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLMkplqlkgsetlknnnrlqvdneiehdqfevsIETSKSSYANAVFKSFt 284
Cdd:COG2223   148 LAPLLIAAFGWRNAFLILGILLLVVAVLAWLF-------------------------------LRDPPAGAAAAAKASL- 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 285 gfaKDMKVLYKEKVFVVNVLGYVSYNFVIGAYSYWGPKAGYNIYKMKNAD-MIFGAVTIICGIVGTLSGGFILDRVtati 363
Cdd:COG2223   196 ---RDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATaGLLAALFALLGALGRPLGGWLSDRI---- 268

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 364 pNAFKLLSGATFLGAVFCFT-AFTLKSLYGFIALFALGELLVFATQAPVNYVCLHCVKPSLRPLSMAIsTVAIHIFGDVP 442
Cdd:COG2223   269 -GGRRVLLIVFALMALGLLLlALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGL-VGAAGGLGGFL 346

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1063704497 443 SSPLVGIVQDHINSWRkTTLILTSILFLAAAIWFIGIF 480
Cdd:COG2223   347 GPLLFGALLDATGSYT-AAFLVFAVLALVALVLTLLLY 383
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 93-238 6.45e-14

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 73.37  E-value: 6.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  93 IQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASF 167
Cdd:cd17474    25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLAdrfgrKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063704497 168 ISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKhFSWRYAFWGEAVLMAP-FAVLGFLMKP 238
Cdd:cd17474   105 GPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVaFLAILFLLPE 175
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 37-413 1.47e-13

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 72.39  E-value: 1.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  37 LEIVESSSSLSPVWLLVIFC-IINLLNYMDRGAIAsngvngstrscndkgkcTLATGIQGHFNLSNFEDGVLSSSFMVGL 115
Cdd:TIGR00895   3 QNNIRKQPLSRYQWRAIILSfLIMLMDGYDLAAMG-----------------FAAPAISAEWGLDPVQLGFLFSAGLIGM 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 116 LIASPIFASLAKRLIGVGLTVWTIAVLG---CGSSFA--FWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGL 190
Cdd:TIGR00895  66 AFGALFFGPLADRIGRRRVLLWSILLFSvftLLCALAtnVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGL 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 191 FYMCIPSGVALGYVYGGYVGKHFSWRYAFWGEAVlmAPFAVLGFLMKPL-------QLKGSETLKNNNRLQVDNEIEHDQ 263
Cdd:TIGR00895 146 MFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGI--APLLLLLLLMRFLpesidflVSKRPETVRRIVNAIAPQMQAEAQ 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 264 FEVSIETSKSSYANAVFKSFtgFAKDMKvlykeKVFVVNVLGYVSYNFVIGAYSYWGPK----AGYNIYKMknadMIFGA 339
Cdd:TIGR00895 224 SALPEQKSTQGTKRSVFKAL--FQGKTA-----RITVLLWLLYFMLLVGVYFLTNWLPKlmveLGFSLSLA----ATGGA 292

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063704497 340 VTIICGIVGTLSGGFILDRVTATIPNAFKLLSGATFLGAVFCFTAFTLKSLYGFIA-LFALGELLVFATQAPVNY 413
Cdd:TIGR00895 293 LFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAgFFVNGGQSGLYALMALFY 367
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 48-385 1.98e-13

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 71.89  E-value: 1.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  48 PVWLLVIFCIINLLNYMdrgaiasngVNGSTRSCndkgkctlATGIQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLAK 127
Cdd:cd17336     1 PKVFVVLLCLLGLLQGA---------VVSYFVST--------ITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGG 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 128 -----RLIGVGLTvwtIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALG 202
Cdd:cd17336    64 rghrpRWIGIGSI---LMGLGCFLLALPHFLFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALG 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 203 YVYGGYvgkhFSWRYAFWGEAVL-MAP------------FAVLGFLMkplqlkgsetlknnnrlqvdneiehdqFEVSIe 269
Cdd:cd17336   141 FLLGSF----LLRIYVDFSRVPLgITPddprwigawwlgFLILGILL---------------------------LIVSI- 188

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 270 tskssyanavfkSFTGFAkdmkvlykeKVFVVNVLGYVSYNFVIGAYSYWGPKAGYNIYKMK--NADMIFGAVTIICGIV 347
Cdd:cd17336   189 ------------PLFFFP---------PIFILLLLAIVFESFAISGFSTFLPKYLETQFRLSasLASLLTGLILVPGAAL 247

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1063704497 348 GTLSGGFILDRVTATIPNAFKLLSGATFLGAVFCFTAF 385
Cdd:cd17336   248 GILLGGLIIKKFKLTARGLAKFVLILSLLSVILYISLF 285
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 93-239 1.05e-12

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 69.53  E-value: 1.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  93 IQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASF 167
Cdd:cd17503    22 IMGDLGASLDTVQWVITSYLLALAIMIPLSGWLAdrfgtRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVL 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063704497 168 ISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWgeavLMAPFAVLGFLMKPL 239
Cdd:cd17503   102 IPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFY----INLPIGILALLLAPL 169
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 97-237 1.91e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 65.68  E-value: 1.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  97 FNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLA 171
Cdd:cd17325   230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSdrigrKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAT 309

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063704497 172 APFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLMK 237
Cdd:cd17325   310 LALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
93-399 5.57e-11

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 64.10  E-value: 5.57e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  93 IQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLAKRL-----IGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASF 167
Cdd:COG0738    34 LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFgykrgLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLL 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 168 ISLAAPFIDDNAPqEQKAAWLGLFYMCIPSGVALGYVYGGYV---GKHFSWRYAFWgeaVLMAPFAVLGFLMKPLQLKGS 244
Cdd:COG0738   114 DVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLillGLSLSWHLPYL---ILAVLLLLLALLFLRSKLPEI 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 245 ETLKNNNrlqvdneiehdqfevsietskssyanavfksfTGFAKDMKVLYKEKVFVVNVLGYVSYNFVIGAYSYWGPKAG 324
Cdd:COG0738   190 EEEEEEA--------------------------------AGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYL 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063704497 325 YNIYKMKNAD-MIFGAVTIICGIVGTLSGGFILDRVtatipNAFKLLSGATFLGAVFCFTAFTLKSLYGFIALFAL 399
Cdd:COG0738   238 KDVLGLSEATaALGLSLFWGGMTIGRFLGGFLLKRF-----GPVRLLRLSALLAAVGLLLALLAPGPWLALIGLAL 308
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 93-239 1.13e-10

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 63.37  E-value: 1.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  93 IQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASF 167
Cdd:cd17504    22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGdlygrKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVF 101

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063704497 168 iSLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWgeavLMAPFAVLGFLMKPL 239
Cdd:cd17504   102 -PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFW----TAAPVAVLLAALVPL 168
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 93-238 1.74e-10

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 62.59  E-value: 1.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  93 IQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASF 167
Cdd:cd17323    25 IAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSelygrRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSP 104

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063704497 168 ISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLMKP 238
Cdd:cd17323   105 LAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLP 175
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 109-236 2.28e-10

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 62.19  E-value: 2.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 109 SSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQ 183
Cdd:cd17321    38 NAYLLAFAALLLLAGRLGdrfgrKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGER 117

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063704497 184 KAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWgeavLMAPFAVLGFLM 236
Cdd:cd17321   118 RGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFL----INVPIGLVALLL 166
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 96-237 2.84e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 58.76  E-value: 2.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  96 HFNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISL 170
Cdd:cd17489    25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLdrfgrKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063704497 171 AAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLMK 237
Cdd:cd17489   105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVK 171
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 93-236 3.03e-09

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 58.78  E-value: 3.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  93 IQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLAK-----RLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASF 167
Cdd:cd06173   235 AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKrrrrgRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLF 314

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063704497 168 ISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLM 236
Cdd:cd06173   315 NVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 146-385 7.59e-09

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 58.20  E-value: 7.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 146 SSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHF------------ 213
Cdd:TIGR00805 167 KSLMWLLFLVSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYvdtgsvntedli 246

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 214 ------SWRYAFWGEAVL---MAPFAVLGFLMKPLQLKGsETLKNNNRLqVDNEIEHDQFEvsietsKSSYANAVFKSft 284
Cdd:TIGR00805 247 itptdpRWIGAWWIGFLVcgfVALLTSIPLFFFPKTLPK-EGKRVNVDV-HEAEKLEKSRG------EDRKKNSGITK-- 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 285 GFAKDMKVLYKEKVFVVNVLGYVSYNFVIGAYSYWGPKAGYNIYKMKNADMIF--GAVTIICGIVGTLSGGFILDRVTAT 362
Cdd:TIGR00805 317 DFPKFIKRLLCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLliGVVNVPPIGLGYLIGGFIMKKFKLN 396

                         250       260
                  ....*....|....*....|...
gi 1063704497 363 IPNAFKLLSGATFLGAVFCFTAF 385
Cdd:TIGR00805 397 VKKAAYFAICLSTLEYLLYSPKF 419
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 109-399 1.08e-08

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 57.20  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 109 SSFMVGLLIASPIFASLAKRL-----IGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQ 183
Cdd:cd17320    41 SAYLLGFALGQLLYGPLSDRFgrrpvLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAE 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 184 KAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWgeavLMAPFAVLGFLMKPLQLKgsETLKNNNRLQvdneiehdq 263
Cdd:cd17320   121 LAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFV----FLALLGLLLLLLVLLFLP--ETLPEEKRKP--------- 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 264 fevsietskssyanavfkSFTGFAKDMKVLYKEKVFVVNVLGYVSYNFVIGAYSYWGPKAGYNIYKMKNAD-MIFGAVTI 342
Cdd:cd17320   186 ------------------LLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQfGLLFALNA 247

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063704497 343 ICGIVGTLSGGFILDRVtaTIPNAFKLLSGATFLGAVFC--FTAFTLKSLYGFIALFAL 399
Cdd:cd17320   248 IALILGSLLNGRLVRRF--GPRRLLRLGLLLLLAAALVLllAALLGGLSLWPLVAPLFL 304
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 48-382 4.92e-08

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 55.34  E-value: 4.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  48 PVWLLVIFCIinllNYMDRGAIASNGVNGSTrscndkgkctlaTGIQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLAK 127
Cdd:cd17403     1 PKGFLFFLCI----FAFLQGMVVNGFVNVSI------------TTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGG 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 128 -----RLIGVGLTVwtiavLGCGS-SFA---FWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSG 198
Cdd:cd17403    65 rghkpRWLGIGAFI-----MGIGSlVFAlphFTVFILAQLLHGAGATPLYTLGVTYLDENVSTKMSPLYIGIFYAMAILG 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 199 VALGYVYGGYvgkhFSWRYAFWGEAVLMAPFAV----------LGFLMkplqlkgsetlknnnrlqvdneiehdqfevsi 268
Cdd:cd17403   140 PAIGYVLGGF----LLNLYTDIDQVDSELGLTPddprwvgawwLGFLI-------------------------------- 183

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 269 eTSKSSYANAVFksFTGFAkdmkvlykeKVFVVNVLGYVSYNFVIGAYSYWGPKAGYNIYKMK--NADMIFGAVTIICGI 346
Cdd:cd17403   184 -SGALALIIAFP--LLGFP---------PTFMFLNLAGASEGMLLAGFATFLPKLIESQFSLSasLAALLVGVVVVPGGI 251

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1063704497 347 VGTLSGGFILDRVTATIPNAFKLLSGATFLGAVFCF 382
Cdd:cd17403   252 LGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLFSF 287
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 96-414 7.79e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 54.14  E-value: 7.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  96 HFNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISL 170
Cdd:cd17316    30 SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGdrigrKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPG 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 171 AAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFS----WRYAFWgeavLMAPFAVLGFLMKplqlkgset 246
Cdd:cd17316   110 ASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILFL----IGALPALLALLLR--------- 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 247 lknnnrlqvdneiehdqfevsietskssyanavfksftgfakdmkvlykeKVFVVNVLGYVSYNFVIGAYSYWGPKAGYN 326
Cdd:cd17316   177 --------------------------------------------------RRTLLLILLWFFISFGYYGLTTFLPTYLQT 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 327 IYKMKNADM-IFGAVTIICGIVGTLSGGFILDRVtatipNAFKLLSGATFLGAVFCFTAFTLKSLyGFIALFALGELLVF 405
Cdd:cd17316   207 VLGLSPATSsLYLLLISLGALVGALIAGLLSDRI-----GRKKTLVIGLILSGILALPLFYLLSG-SPTLLLLLLFILSF 280


                  ....*....
gi 1063704497 406 ATQAPVNYV 414
Cdd:cd17316   281 FVGGVWGAL 289
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 96-236 1.25e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 53.73  E-value: 1.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  96 HFNLSNFEDGVLSSSFMVGLLIASPIFASL------AKRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFIS 169
Cdd:cd17474   228 LYGISPIIIGLLFAGWSVLLALGSLFVGRLlkkrfgARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLP 307

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063704497 170 LAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLM 236
Cdd:cd17474   308 LLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 113-474 1.63e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 53.39  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 113 VGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAW 187
Cdd:cd17329    46 VAGIVASLIGGRLAdrfgrKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRA 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 188 LGLFYMCIPSGVALGYVYGGYVGKhFSWRYAFWGEAVLM-APFAVLGFLMKPLQLKGSETLKnnnrlqvdneiehdqfev 266
Cdd:cd17329   126 FSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFlLAALVLLFLLPETRPKRRAAEK------------------ 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 267 sietskssyanavfksfTGFAKDMKVLYKEKVFVVNVLGYVSYNFVIGAYSYWGPKAGYNIykMKNADMIFGAVTIICGI 346
Cdd:cd17329   187 -----------------TEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEI--LGLGESLLGLLLALNAL 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 347 VgTLSGGFILDRVTATIPNAFKLLSGATFLGAVFCFTAF--TLKSLYGFIALFALGELLVF-ATQAPVNyvclHCVKPSL 423
Cdd:cd17329   248 L-IVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFanTLAVLILAMIVLTLGEMLVFpAVQTLVA----ALAPPDK 322

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063704497 424 RPLSMAISTVAIHIfGDVPSSPLVGIVQDHINSWRkTTLILTSILFLAAAI 474
Cdd:cd17329   323 RGSYMGFYALAWGL-GRAIGPLVGGLLLDLLGPGL-PWLILAALGLIAAAL 371
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 96-234 3.24e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 52.43  E-value: 3.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  96 HFNLSNFEDGVLSSSFMVGLLIASPIFASLAKR------LIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFIS 169
Cdd:cd06174   233 LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRligrkpLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLP 312

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063704497 170 LAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGK-HFSWRYAFWGEAVLMAPFAVLGF 234
Cdd:cd06174   313 LSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAaTFGLTGAFLVLAVLLLLAAILLL 378
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 92-236 3.57e-07

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 52.18  E-value: 3.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  92 GIQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMF--VGVGE 164
Cdd:cd17359    26 FLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLAdrfgrRKTLLISAVLFFISALGSAFSPNFTIFIIARIIggLAVGG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 165 ASFISLAapFIDDNAPQEQKAAWLGLFYMCIPSGVALGYV--------YGGYVGKHFSWRYAFWGEAVlmaPFAVLGFLM 236
Cdd:cd17359   106 ASALVPM--YIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIvnylianaGGADWLGAEGWRWMLGLEAI---PAILFLLGM 180
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 109-242 7.73e-07

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 51.61  E-value: 7.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 109 SSFMVGLLIASPIFASLAKR-----LIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQ 183
Cdd:TIGR00711  44 TSYMLANAISIPLTGWLAKRfgtrrLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEK 123

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063704497 184 KAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFW-----GEAVLMAPFAVLGFlMKPLQLK 242
Cdd:TIGR00711 124 RGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLinvpiGIIVVVVAFFILPR-DKPAASE 186
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 93-254 2.64e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 49.49  E-value: 2.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  93 IQGHFnlsnfedgVLSSSFMVGLLIASP-----IFASLA---------KRLIGVGLTVWTIAvlGCGSSFA--FWFIVLC 156
Cdd:cd17473    25 IAQHF--------VPNSELLVPLLLTLPalfiaLFAPLAgwladrfgrKRLLIAGLLLYGIG--GVAGLFLdsLYALLAS 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 157 RMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKhFSWRYAFW--GEAVLMAPFAVLgF 234
Cdd:cd17473    95 RALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLvyLLALPVLILVLL-F 172

                         170       180
                  ....*....|....*....|
gi 1063704497 235 LMKPLQLKGSETLKNNNRLQ 254
Cdd:cd17473   173 LPEPARKSKSAASPGAATAA 192
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
42-236 3.24e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 49.49  E-value: 3.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  42 SSSSLSPVWLL---VIFCIINLlnymdRGAIASNGVngstrscndkgkctLATGIQGHFNLSNFEDGVLSSSFMVGLLIA 118
Cdd:COG2807     9 RRSRRAGRWLLllaIVLVALNL-----RPAITSVGP--------------LLPEIRADLGLSATQAGLLTTLPLLAFGLF 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 119 SPIFASLAKRL-----IGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQeQKAAWLGLFYM 193
Cdd:COG2807    70 APLAPRLARRFglertLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTA 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1063704497 194 CIPSGVALGYVYGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLM 236
Cdd:COG2807   149 AMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPL 191
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 97-235 3.90e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 49.11  E-value: 3.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  97 FNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASfISLA 171
Cdd:cd17330    29 LGASGYYVGLLQSSYSLGQFLASPLWGRLSdrygrKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGN-VSVA 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063704497 172 APFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWgeavLMAPFAVLGFL 235
Cdd:cd17330   108 QAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFL----VAAALALLNLV 167
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 96-220 4.80e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 48.84  E-value: 4.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  96 HFNLSNFEDGVLSSSFMVGLLIASPIFASLAKRLIGVGLTVWTI---AVLGCGSSFA--FWFIVLCRMFVGVGEASFISL 170
Cdd:cd17371    28 EFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITIllfAVFTLLCGFAqnYWQLLILRALAGLGFGGEWAA 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063704497 171 AAPFIDDNAPQEQKAAWLGLFYMCIPSG----VALGYVYGGYVGKHFSWRYAFW 220
Cdd:cd17371   108 GAALMAEYVPARHRGKALGYVQSGWAVGwllaTLLAALLFPLLPPEIAWRVLFL 161
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
 91-400 8.72e-06

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 48.12  E-value: 8.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  91 TGIQGHFNLSNFEDGVLSSSFMVGLLIASpIFASL------AKRLIGVGLTVwtiAVLGcgsSFAF---WFIVLCRMFVG 161
Cdd:cd17404    27 TTIEKRYSLKSSESGLIVSSYEIGSLLTV-VFVSYfggrghRPRWIAVGGVL---IALG---SFLFslpHFFILAQILIG 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 162 VGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYvgkhfswryafwgeavlmapfaVLGFLMKPLql 241
Cdd:cd17404   100 MGGTPIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGL----------------------LINFYVDPL-- 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 242 kgsetlknnnrlqvdneiehdQFEVSIETSKSSYANAVFKSF--TGFAKDMKVL----YKEKVFVVNVLGYVSYNFVIGA 315
Cdd:cd17404   156 ---------------------STPPDISPGDPRWIGAWWGGFllCGIALLLVAFpfftFPKMTFLVVSLGYCMELAIVSG 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 316 YSYWGPKAGYNIYKM--KNADMIFGAVTIICGIVGTLSGGFILDRvtatipnaFKL-LSGATFLGAVFCFTAFTLkslyg 392
Cdd:cd17404   215 FITFLPKYLETQFGIpaSNANIFTGVIAVPGAGIGIVLGGYILKR--------FKLgPKGAAKLALICNFLSLLL----- 281


                  ....*...
gi 1063704497 393 FIALFALG 400
Cdd:cd17404   282 FLTLFFLG 289
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 49-238 1.20e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 47.63  E-value: 1.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  49 VWLLVIFCIINLLNYMDRGAIASNGVNGSTRscndkgkctlATGIQGH-FNLSNfedgvlsSSFMVGLLIASPIFASLAK 127
Cdd:cd17327     4 LFILPLLCILYFLQYLDKSNISNAAVMGMKE----------DLKLVGNqYNWGN-------TVFYVGYIIFELPGNLLLQ 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 128 RL-----IGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPsgvaLG 202
Cdd:cd17327    67 RFppskwLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAG----LG 142

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1063704497 203 YVYGGY----------VGKHFSWRYAFWGEAVLMAPFAVLGFLMKP 238
Cdd:cd17327   143 SIFGGLlaygvfkilgVGGLAGWRWLFIIEGLITIIIGLVIFFWLP 188
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 106-236 1.32e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 47.26  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 106 VLSSSFMVgLLIASPIFASLAKR----------LIGVGLTVWTIAVLGCgssfAFWFIVLcRMFVGVgEASFISLAAPFI 175
Cdd:cd17391    41 AFSSTFLV-SAIFSPIWGRLADRygrkpmllraSLGMAIVIGLMAFVTN----VWQLLIL-RLLQGV-FSGYVPNATALI 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063704497 176 DDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWgeavLMAPFAVLGFLM 236
Cdd:cd17391   114 ASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFF----ITGGLLFLAFLL 170
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 100-237 1.73e-05

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 46.83  E-value: 1.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 100 SNFEDGVLSSSFMVGLLIASPIFASLAKRLIGVGLTVWTIAVLGCGSSFA------FWFIVLCRMFVGVGEASFISLAAP 173
Cdd:cd17490   228 SSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLipfapnLTLLYLLQALNGFGTGILFPLLMS 307

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063704497 174 FIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLMK 237
Cdd:cd17490   308 LSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 105-252 3.72e-05

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 46.09  E-value: 3.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 105 GVLSSSFMVGLLIASPIFASLAKRLigvGL-TVWTIAVLGCGSSFAF-------WFIVLCRMFVGVGEASFiSLAAPFID 176
Cdd:cd17388    41 GVLLALYALMQFIFAPILGALSDRF---GRrPVLLLSLAGAALDYLLmafaptlWWLYLGRIIAGITGATG-AVAAAYIA 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063704497 177 DNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGkHFSWRYAFWGEAVLMAPFAVLGFLMKPlqlkgsETLKNNNR 252
Cdd:cd17388   117 DVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLG-EISPRAPFLVAAGLNGLNFLLGLFVLP------ESLPPERR 185
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 88-236 4.94e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 45.69  E-value: 4.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  88 TLATGIQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGV 162
Cdd:cd17475    17 ALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLdrfgeRRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGA 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063704497 163 GEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLM 236
Cdd:cd17475    97 GYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLF 170
Sugar_tr pfam00083
Sugar (and other) transporter;
105-434 6.38e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 45.34  E-value: 6.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 105 GVLSSSFMVGLLIASPIFASLAKRL-----IGVGLTVWTIAVLGCGSS---FAFWFIVLCRMFVGVGeASFISLAAP-FI 175
Cdd:pfam00083  49 GLIVSIFSVGCFIGSLFAGKLGDRFgrkksLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIG-VGGASVLAPmYI 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 176 DDNAPQEQKAAWLGLFYMCIPSGVALGYVYG---GYVGKHFSWRYAFWGEAVLMAPFAVLGFL---------MKPLQLKG 243
Cdd:pfam00083 128 SEIAPKKLRGALGSLYQLAITFGILLAYIFGlglNKTSNSDGWRIPLGLQLVPALLLIIGLLFlpesprwlvEKGRLEEA 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 244 SETLKNNNRLQVDNEiEHDQFEVSIETSKSSYANAVFKSFTGFAKDMKVLYkekVFVVNVLGYVSYNFVIgaySYWGPKa 323
Cdd:pfam00083 208 REVLAKLRGVPDVDR-ELDEIKDSLEAGQEAEKASWKELFSTKTRRQRLLI---GVMLQIFQQLTGINAI---FYYSTT- 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 324 gynIYKM--KNADMIFGAVTIICGIVGTLSGGFILDRVT---------------ATIPNAFKLLSGATFLGAVFCFTAFT 386
Cdd:pfam00083 280 ---IFENlgLSDSFLVTIIVGVVNFVFTFIAIFLVDRFGrrpllllgaagmaicFVILGIVALLGVSKSDWAGIVAIVFI 356

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1063704497 387 lkslYGFIALFALGellvfatQAPVNYVCLHCVKP-SLRPLSMAISTVA 434
Cdd:pfam00083 357 ----ALFIAFFAMG-------WGPVPWVIVSELFPlSVRSKAMALATAA 394
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 96-239 1.11e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.47  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  96 HFNLSNFEDGVLSSSFMVGLLIASPIFASLAKRL-----IGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISL 170
Cdd:cd17477    25 REGVSTALIGLVASAYYLGILLGSPLVPRLIRRVghiraFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVV 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063704497 171 AAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGkHFSWRyAFWGEAVLMApFAVLGFLMKPL 239
Cdd:cd17477   105 SESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVG-TAGAL-PFLIAAVLLL-LALVPLLLTRR 170
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 96-236 2.13e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 43.33  E-value: 2.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  96 HFNLSNFEDGVLSSSFMVGLLIASPIFASLAKR------LIGVGLtVWTIAVLGCGSSFAFWFIVLCRMFVGVGeASFIS 169
Cdd:cd17315    28 GFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRfgrrksLLIAAV-LYVIGALLSALAPNVWVLIVGRFLLGLG-VGLAS 105

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 170 LAAP-FIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFS--WRYAFWGEAVLMAPFAVLGFLM 236
Cdd:cd17315   106 VLVPlYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPgwWRLMFALAAVPALLQLLLMFFL 175
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 109-235 2.68e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 43.36  E-value: 2.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 109 SSFMVGLLIASPIFASLA---------------KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAP 173
Cdd:cd17490    29 SLSMIGIILGAYGISQMLlriplgilsdrigkrKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVL 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063704497 174 FIDDNAPQEQKAAwLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWgeavLMAPFAVLGFL 235
Cdd:cd17490   109 YASYFPPDEAAKA-MGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFL----LAALAGVLGFI 165
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 127-237 2.77e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 43.02  E-value: 2.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 127 KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDN-APQEQKAAWLGLFYMCIPSGVALGYVY 205
Cdd:cd17476    63 KKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTyPPGPRKNIVFSLFGATAPLGFALGGVF 142

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1063704497 206 GGYVGKHFSWRYAFWGEAVLMAPFAVLGFLMK 237
Cdd:cd17476   143 GGLFAQLAWWPWIFWFLAILAAIVAVAAIFWT 174
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 97-232 3.72e-04

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 42.72  E-value: 3.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  97 FNLSNFEDGVLSSSFMVGLLIASPIFASLAKRL-----IGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGeASFISLA 171
Cdd:cd17362    34 YNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLgrrkeLILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVG-IGLAMHA 112

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063704497 172 AP-FIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYG-GYVGKHFSWRYAFwgeaVLMAPFAVL 232
Cdd:cd17362   113 APvYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGyAFADVVGGWRYMY----GLAAPPALL 171
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 108-254 4.01e-04

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 42.76  E-value: 4.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 108 SSSFMVGLLIASPIFASLAKRL-----IGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQE 182
Cdd:TIGR00710  46 LTLYLLGFAAGQLLWGPLSDRYgrrpvLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGE 125

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063704497 183 QKA---AWLGLFYMCIPsgvALGYVYGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLMKPlqlkgsETLKNNNRLQ 254
Cdd:TIGR00710 126 ELSriySILMPVLALAP---AVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILP------ETLPYEARIQ 191
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 111-235 4.61e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 42.53  E-value: 4.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 111 FMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKA 185
Cdd:cd17370   243 FNLVYALAAYPAGRLSdrigrKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRG 322

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1063704497 186 AWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWGEAVLMApFAVLGFL 235
Cdd:cd17370   323 TAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLAL-IALLLLL 371
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
 93-382 5.28e-04

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 42.42  E-value: 5.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  93 IQGHFNLSNFEDGVLSSSFMVGLLIAS------------PIFASLAKRLIGVGLTVWTIAvlgcgssfAFWFIVLCRMFV 160
Cdd:cd17463    30 IEKRYELSSSLTGLISSSYDISFCLLSlfvsfygerghkPRWLAFSAFMIGLGSLVFSLP--------HFFVFILGQLLL 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 161 GVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGY-------VGKHFS---------WRYAFWgeav 224
Cdd:cd17463   102 GVGGTPLYTLGTAYIDDSVPTHKSSLYIGIGYGMSVLGPAIGYLLGGQllniyidVNKGQSvdlteedprWLGAWW---- 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 225 lmapfavLGFLMKPLqlkgsetlknnnrlqvdneiehdqfevsietskssYANAVFKSFTGFAKDMKVLYKEKVFVVNVL 304
Cdd:cd17463   178 -------IGFLMCWL-----------------------------------IAWCLIAPFSCFPKHLPGLLKNPVFMCLTI 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 305 GYVSYNFVIGAYSYWGPKAGYNIYKMKN--ADMIFGAVTIICGIVGTLSGGFILDRVTATIPNAFKLLSGATFLGAVFCF 382
Cdd:cd17463   216 SSCSEALITTGFATFLPKFIENQFGQTSsfAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIKFAIITTTVSLLLLS 295
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
 48-249 5.73e-04

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 42.13  E-value: 5.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  48 PVWLLVIFCIINLLNYMDrgaiasngVNGSTRscndkgkcTLATGIQGHFNLSNFEDGVLSSSFMvgllIASPIFASLAK 127
Cdd:cd17462     1 PKGVLFFLCAASFLQGMT--------VNGFIN--------TVITSIERRFDLRSYQSGLIASSYD----IAACLCLTFVS 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 128 RLIGVGLTV----WTIAVLGCGS-SFA---FWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGV 199
Cdd:cd17462    61 YFGGSGHKPrwlgWGVLIMGLGSlVFAlphFTVFMLGQFLHGIGATPLYTLGVTYLDENVKSNYSPVYIGIFYTAAIVGP 140

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 200 ALGYVYGGYVGKHFS--------------WRYAFW------GEAVLMAPFAVLGFlmkPLQLKGseTLKN 249
Cdd:cd17462   141 AAGYLLGGFFLNIYTeigrqteltpenplWVGAWWigflgaGAAALLIALPILGY---PRQLPG--LLKN 205
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 109-220 6.61e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 41.78  E-value: 6.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 109 SSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQ 183
Cdd:cd17502    37 TAYLLTSTAFQPIYGKLSdlfgrKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRE 116

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1063704497 184 KAAWLGlfYMCIPSGVA--LGYVYGGYVGKHFSWRYAFW 220
Cdd:cd17502   117 RGKYQG--YIGAVFGIAsvAGPLIGGAFTDHLSWRWCFY 153
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 96-225 6.90e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 41.80  E-value: 6.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  96 HFNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISL 170
Cdd:cd17365    28 DWGLSPAQLGPVGSAALFGMAIGALLAGPLAdrfgrKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPN 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063704497 171 AAPFIDDNAPQEQKAAWLGLFYmcipSGVALGYVYGGYVG----KHFSWRYAFWGEAVL 225
Cdd:cd17365   108 AITLVSEYAPARRRSLAVTLMF----CGYPLGAALGGFLAaaliPAFGWRSVFLLGGVP 162
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 105-236 3.23e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.88  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 105 GVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNA 179
Cdd:cd17489   230 GLFFTVYAIALLLSRPFSGKLSdrkgpKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLV 309

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063704497 180 PQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFwgeaVLMAPFAVLGFLM 236
Cdd:cd17489   310 PPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMF----LLAAVVVLLALVL 362
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 105-477 4.03e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.52  E-value: 4.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 105 GVLSSSFMVGLLIASPIFASLAKRL----------IGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPF 174
Cdd:cd06173    37 GLVLAAFFLPFLLFSPFAGVLADRFdrrrlliladLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQAL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 175 IDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLMKPLqlkgsetlknnnrlq 254
Cdd:cd06173   117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRP--------------- 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 255 vdneiehdqFEVSIETSKSSYANAVFKSFTGFAKDMKVLYkekVFVVNVLgyvsYNFVIGAYsyWGPKAGYNIYKMKNAD 334
Cdd:cd06173   182 ---------PPAAPGESSSLLLRDLREGLRYLRRSPLLRL---LLLALAL----FALLGGAL--TVLLPLLAKEVLGGGA 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 335 MIFGAVTIICGIvGTLSGGFILDRVTATIpNAFKLLSGATFLGAVFCFTAFTLKSLYGFIALFALGELLVFATQAPVNYV 414
Cdd:cd06173   244 AGYGLLLAAFGV-GALLGALLLGRLSKRR-RRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTL 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063704497 415 CLHCVKPSLRPLSMAISTVAIHIFGDVpSSPLVGIVQDHInSWRKTTLILTSILFLAAAIWFI 477
Cdd:cd06173   322 LQLRVPDELRGRVFSVYNALNSGAMPL-GALLAGLLADAL-GLSAVFLLAGALLLLAALLLLL 382
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 92-231 4.27e-03

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 39.54  E-value: 4.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  92 GIQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTI-AVLGCGSSFAFWFIVLCRMFVGVGEA 165
Cdd:cd17356    35 DNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSdrigrKKSIQIGCVIYIIgAIIQVAAIGKWYQLIVGRIIAGLGVG 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063704497 166 SFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGY--VYG-GYVGKHFSWRYAF-----WGEAVLMAPFAV 231
Cdd:cd17356   115 FASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYciNYGtHKLDGSAQWRIPLglqivWGLLLLIGMFFL 188
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 92-236 4.32e-03

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 39.56  E-value: 4.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  92 GIQGHFNLSNFEDGVLSSSF----MVGLLIaSPIFA--SLAKRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRM----FVG 161
Cdd:cd17312    28 PIVEEIGLSKDDLGIIGSAFliayAVGKFI-SGFLSdrSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGlnglFQS 106

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063704497 162 VGEASFISLAAPFIDdnapQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWGEAVLMAPFAVLGFLM 236
Cdd:cd17312   107 MGWPPCVKLLGNWFS----KKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFF 177
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
105-236 4.42e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 39.47  E-value: 4.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 105 GVLSSSFMVGLLIASPIFASLAKRLIGVGLTVWTIAVLGCGSSFAFWF-----IVLCRMFVGVGEASFISLAAPFIDDNA 179
Cdd:COG2807   253 GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLapgslPWLWAVLLGLGQGGLFPLALTLIGLRA 332

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063704497 180 PQEQKAAWL-GLFYMCIPSGVALGYVYGGYVGKHF-SWRYAFWGEAVLMAPFAVLGFLM 236
Cdd:COG2807   333 RTPAEAAALsGMAQSVGYLLAALGPLLVGALHDATgSWTAALLLLAALAVLMLVAGLLA 391
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
 88-213 4.46e-03

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 39.53  E-value: 4.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  88 TLATGIQGHFNLSNFEDGVLSSSFMVG---LLIASPIFASLAKR--LIGVGLTVWTIAVLGCG----------SSFAFWF 152
Cdd:cd17402    24 SVLTTLERRFNLQSADVGVIASSFEIGnlaLILFVSYFGARGHRprLIGCGGIVMALGALLSAlpeflthqykTNMMYLL 103

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063704497 153 IVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHF 213
Cdd:cd17402   104 LIGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIY 164
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 93-407 5.49e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.08  E-value: 5.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497  93 IQGHFNLSNFEDGVLSSSFMVGLLIASPIFASLA-----KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASF 167
Cdd:cd17478    22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLAdrkprRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 168 ISLAAPFIDDNAPqEQKAAWLGLFYMCIPSGVALGYVYGGYVGKHFSWRYAFWgeaVLMAPFAVLGFLMKPLQLKGSETL 247
Cdd:cd17478   102 HPEGARLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLI---LLIIPGLAVALLLLRLRPLKKPEA 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 248 KnnnrlqvdneiEHDQFEVSIETSKSSYANAVFKSFTGFAKDMkvlykekvFVVNVLGYVSYNFVIGAYSYWGpkAGYNI 327
Cdd:cd17478   178 K-----------KAAAKSSARSTLKGVWRALLLLLIIVFLRSW--------VLSSLTTFLPFYLVQRGYSLVF--AGLLL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 328 ykmknadmifgAVTIICGIVGTLSGGFILDRVtatipnAFKLLSGATFLGAVFCFTAFTLKSLYGFIALFALGELLVFAT 407
Cdd:cd17478   237 -----------SLFLFAGAIGTLIGGPLSDRF------GRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFAS 299
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 127-242 6.92e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 38.75  E-value: 6.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063704497 127 KRLIGVGLTVWTIAVLGCGSSFAFWFIVLCRMFVGVGEASFISLAAPFIDDNAPQEQKAAWLGLFYMCIPSGVALGYVYG 206
Cdd:cd17329   266 RKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVG 345

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1063704497 207 GYVGKHFSWRYAFWGeavlmapFAVLGFLMKPLQLK 242
Cdd:cd17329   346 GLLLDLLGPGLPWLI-------LAALGLIAAALLLG 374
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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