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Conserved domains on  [gi|1063707112|ref|NP_001324313|]
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WD40 domain-containing protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12898885)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 228-609 3.12e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 188.70  E-value: 3.12e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  228 NIKKLRGHRNAVYCAIFDRSGRYVITGSDDRLVKIWSMETALCLASCRGHEGDITDLAVSSNNALVASASNDFVIRVWRL 307
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  308 PDGMPISVLRGHTGAVTAIAFSPrqaSVYQLLSSSDDGTCRIWDARysqwlpriyvpspsdanTGESTFTSSntgstsna 387
Cdd:cd00200     81 ETGECVRTLTGHTSYVSSVAFSP---DGRILSSSSRDKTIKVWDVE-----------------TGKCLTTLR-------- 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  388 SQSHQILCCAYNANGTIFVTGSSDSNARVWSASKPNLddaeqptheLDVLRGHENDVNYVQFSgcavaPKSStadalked 467
Cdd:cd00200    133 GHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC---------VATLTGHTGEVNSVAFS-----PDGE-------- 190

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  468 sypkfknswfchdNIVTCSRDGSAIIWTPRSrkfhGKSGRWMKGyHLKvpppplppqpprggprqrflptprGVNMIIWS 547
Cdd:cd00200    191 -------------KLLSSSSDGTIKLWDLST----GKCLGTLRG-HEN------------------------GVNSVAFS 228

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063707112  548 LDNRFVLAAIMDCRICVWNAADGSLVHCLTGHSESSYVLDVHPFNPRIAmSAGYDGKTIIWD 609
Cdd:cd00200    229 PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA-SGSADGTIRIWD 289
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1400-1529 6.89e-46

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99958  Cd Length: 128  Bit Score: 161.35  E-value: 6.89e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112 1400 GETSLHSPWEFDNPEfpWEKSTIEDERREKLLSLFAGLVKSISKHQDSYGIQKLNEAAQKMDFCNRFPVPLYPELIHERL 1479
Cdd:cd05529      1 LYNPLSSEWELFDPG--WEQPHIRDEERERLISGLDKLLLSLQLEIAEYFEYPVDLRAWYPDYWNRVPVPMDLETIRSRL 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1063707112 1480 ENQYYRSIESFKHDVDAMLSNAELYFVRSAHMLSKIKRLRDKLTKTLRKL 1529
Cdd:cd05529     79 ENRYYRSLEALRHDVRLILSNAETFNEPNSEIAKKAKRLSDWLLRILSSL 128
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 572-656 1.43e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 48.87  E-value: 1.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  572 LVHCLTGHSESSYVLDVHPFNPRIAmSAGYDGKTIIWDIWEGIPIKVYEIGRFKLVDGKFSQDGTSIVLSDDVGQIYFLN 651
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79


                   ....*
gi 1063707112  652 TGQGE 656
Cdd:cd00200     80 LETGE 84
PTZ00108 super family cl36510
DNA topoisomerase 2-like protein; Provisional
 775-921 2.86e-03

DNA topoisomerase 2-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00108:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 42.34  E-value: 2.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  775 HEVLSDDNDSEYNAEVSSDGARASPCSNSSNELECSSEDSDVENIHESSYHWKRRRKHPKVNVSTSSG----RRDKRILD 850
Cdd:PTZ00108  1218 SNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPpppsKRPDGESN 1297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  851 ENDSSNSGIKRTKNRRI------------------VVKASKRKHSDVKASRPQRAAAQNARSLLSKISGSSSDEVDDDND 912
Cdd:PTZ00108  1298 GGSKPSSPTKKKVKKRLegslaalkkkkksekktaRKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSE 1377


                   ....*....
gi 1063707112  913 SSNSESDRS 921
Cdd:PTZ00108  1378 DEDDEDDED 1386
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 228-609 3.12e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 188.70  E-value: 3.12e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  228 NIKKLRGHRNAVYCAIFDRSGRYVITGSDDRLVKIWSMETALCLASCRGHEGDITDLAVSSNNALVASASNDFVIRVWRL 307
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  308 PDGMPISVLRGHTGAVTAIAFSPrqaSVYQLLSSSDDGTCRIWDARysqwlpriyvpspsdanTGESTFTSSntgstsna 387
Cdd:cd00200     81 ETGECVRTLTGHTSYVSSVAFSP---DGRILSSSSRDKTIKVWDVE-----------------TGKCLTTLR-------- 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  388 SQSHQILCCAYNANGTIFVTGSSDSNARVWSASKPNLddaeqptheLDVLRGHENDVNYVQFSgcavaPKSStadalked 467
Cdd:cd00200    133 GHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC---------VATLTGHTGEVNSVAFS-----PDGE-------- 190

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  468 sypkfknswfchdNIVTCSRDGSAIIWTPRSrkfhGKSGRWMKGyHLKvpppplppqpprggprqrflptprGVNMIIWS 547
Cdd:cd00200    191 -------------KLLSSSSDGTIKLWDLST----GKCLGTLRG-HEN------------------------GVNSVAFS 228

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063707112  548 LDNRFVLAAIMDCRICVWNAADGSLVHCLTGHSESSYVLDVHPFNPRIAmSAGYDGKTIIWD 609
Cdd:cd00200    229 PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA-SGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
232-610 1.14e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.89  E-value: 1.14e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  232 LRGHRNAVYCAIFDRSGRYVITGSDDRLVKIWSMETALCLASCRGHEGDITDLAVSSNNALVASASNDFVIRVWRLPDGM 311
Cdd:COG2319    116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  312 PISVLRGHTGAVTAIAFSPRQAsvyQLLSSSDDGTCRIWDARysqwlpriyvpspsdanTGESTFTSSntgstsnaSQSH 391
Cdd:COG2319    196 LLRTLTGHTGAVRSVAFSPDGK---LLASGSADGTVRLWDLA-----------------TGKLLRTLT--------GHSG 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  392 QILCCAYNANGTIFVTGSSDSNARVWSAskpnlddaeQPTHELDVLRGHENDVNYVQFSgcavaPKSSTadalkedsypk 471
Cdd:COG2319    248 SVRSVAFSPDGRLLASGSADGTVRLWDL---------ATGELLRTLTGHSGGVNSVAFS-----PDGKL----------- 302

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  472 fknswfchdnIVTCSRDGSAIIWTPRSrkfhGKSGRWMKGYHlkvpppplppqpprggprqrflptpRGVNMIIWSLDNR 551
Cdd:COG2319    303 ----------LASGSDDGTVRLWDLAT----GKLLRTLTGHT-------------------------GAVRSVAFSPDGK 343

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063707112  552 FVLAAIMDCRICVWNAADGSLVHCLTGHSESSYVLDVHPFNPRIAmSAGYDGKTIIWDI 610
Cdd:COG2319    344 TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA-SGSADGTVRLWDL 401
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1400-1529 6.89e-46

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 161.35  E-value: 6.89e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112 1400 GETSLHSPWEFDNPEfpWEKSTIEDERREKLLSLFAGLVKSISKHQDSYGIQKLNEAAQKMDFCNRFPVPLYPELIHERL 1479
Cdd:cd05529      1 LYNPLSSEWELFDPG--WEQPHIRDEERERLISGLDKLLLSLQLEIAEYFEYPVDLRAWYPDYWNRVPVPMDLETIRSRL 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1063707112 1480 ENQYYRSIESFKHDVDAMLSNAELYFVRSAHMLSKIKRLRDKLTKTLRKL 1529
Cdd:cd05529     79 ENRYYRSLEALRHDVRLILSNAETFNEPNSEIAKKAKRLSDWLLRILSSL 128
BROMO smart00297
bromo domain;
1425-1529 5.11e-18

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 80.79  E-value: 5.11e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  1425 ERREKLLSLFAGLVKSISKHQDSYGIQKLNEAAQKMDFCNRFPVPLYPELIHERLENQYYRSIESFKHDVDAMLSNAELY 1504
Cdd:smart00297    3 KLQKKLQELLKAVLDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTY 82

                            90       100
                    ....*....|....*....|....*
gi 1063707112  1505 FVRSAHMLSKIKRLRDKLTKTLRKL 1529
Cdd:smart00297   83 NGPDSEVYKDAKKLEKFFEKKLREL 107
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 309-351 2.93e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 2.93e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1063707112   309 DGMPISVLRGHTGAVTAIAFSPRQasvYQLLSSSDDGTCRIWD 351
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDG---KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
310-351 3.30e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 3.30e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1063707112  310 GMPISVLRGHTGAVTAIAFSPRQAsvyQLLSSSDDGTCRIWD 351
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGK---LLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 241-450 1.47e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.17  E-value: 1.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  241 CAI-FDRSGRYVITGSDDRLVKIWSMETalCLASCRGHEGDITDLAVSSN----------NALVASASNDFVIRVWRLPD 309
Cdd:PLN00181   487 CAIgFDRDGEFFATAGVNKKIKIFECES--IIKDGRDIHYPVVELASRSKlsgicwnsyiKSQVASSNFEGVVQVWDVAR 564

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  310 GMPISVLRGHTGAVTAIAFSPRQASVyqLLSSSDDGTCRIWDARYSQWLPRIyvpsPSDANTGESTFTSSNTGSTSNASQ 389
Cdd:PLN00181   565 SQLVTEMKEHEKRVWSIDYSSADPTL--LASGSDDGSVKLWSINQGVSIGTI----KTKANICCVQFPSESGRSLAFGSA 638

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  390 SHQI-----------LCCAYNANGTI----------FVTGSSDSNARVWSASKPNLDDAEQPTHEldvLRGHENDVNYVQ 448
Cdd:PLN00181   639 DHKVyyydlrnpklpLCTMIGHSKTVsyvrfvdsstLVSSSTDNTLKLWDLSMSISGINETPLHS---FMGHTNVKNFVG 715


                   ..
gi 1063707112  449 FS 450
Cdd:PLN00181   716 LS 717
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 572-656 1.43e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.87  E-value: 1.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  572 LVHCLTGHSESSYVLDVHPFNPRIAmSAGYDGKTIIWDIWEGIPIKVYEIGRFKLVDGKFSQDGTSIVLSDDVGQIYFLN 651
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79


                   ....*
gi 1063707112  652 TGQGE 656
Cdd:cd00200     80 LETGE 84
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 1461-1505 4.71e-05

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 43.46  E-value: 4.71e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1063707112 1461 DFCNRFPVPLYPELIHERLENQYYRSIESFKHDVDAMLSNAELYF 1505
Cdd:pfam00439   28 DYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYN 72
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 775-921 2.86e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 42.34  E-value: 2.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  775 HEVLSDDNDSEYNAEVSSDGARASPCSNSSNELECSSEDSDVENIHESSYHWKRRRKHPKVNVSTSSG----RRDKRILD 850
Cdd:PTZ00108  1218 SNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPpppsKRPDGESN 1297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  851 ENDSSNSGIKRTKNRRI------------------VVKASKRKHSDVKASRPQRAAAQNARSLLSKISGSSSDEVDDDND 912
Cdd:PTZ00108  1298 GGSKPSSPTKKKVKKRLegslaalkkkkksekktaRKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSE 1377


                   ....*....
gi 1063707112  913 SSNSESDRS 921
Cdd:PTZ00108  1378 DEDDEDDED 1386
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 228-609 3.12e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 188.70  E-value: 3.12e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  228 NIKKLRGHRNAVYCAIFDRSGRYVITGSDDRLVKIWSMETALCLASCRGHEGDITDLAVSSNNALVASASNDFVIRVWRL 307
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  308 PDGMPISVLRGHTGAVTAIAFSPrqaSVYQLLSSSDDGTCRIWDARysqwlpriyvpspsdanTGESTFTSSntgstsna 387
Cdd:cd00200     81 ETGECVRTLTGHTSYVSSVAFSP---DGRILSSSSRDKTIKVWDVE-----------------TGKCLTTLR-------- 132

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  388 SQSHQILCCAYNANGTIFVTGSSDSNARVWSASKPNLddaeqptheLDVLRGHENDVNYVQFSgcavaPKSStadalked 467
Cdd:cd00200    133 GHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC---------VATLTGHTGEVNSVAFS-----PDGE-------- 190

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  468 sypkfknswfchdNIVTCSRDGSAIIWTPRSrkfhGKSGRWMKGyHLKvpppplppqpprggprqrflptprGVNMIIWS 547
Cdd:cd00200    191 -------------KLLSSSSDGTIKLWDLST----GKCLGTLRG-HEN------------------------GVNSVAFS 228

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063707112  548 LDNRFVLAAIMDCRICVWNAADGSLVHCLTGHSESSYVLDVHPFNPRIAmSAGYDGKTIIWD 609
Cdd:cd00200    229 PDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA-SGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
232-610 1.14e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.89  E-value: 1.14e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  232 LRGHRNAVYCAIFDRSGRYVITGSDDRLVKIWSMETALCLASCRGHEGDITDLAVSSNNALVASASNDFVIRVWRLPDGM 311
Cdd:COG2319    116 LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK 195

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  312 PISVLRGHTGAVTAIAFSPRQAsvyQLLSSSDDGTCRIWDARysqwlpriyvpspsdanTGESTFTSSntgstsnaSQSH 391
Cdd:COG2319    196 LLRTLTGHTGAVRSVAFSPDGK---LLASGSADGTVRLWDLA-----------------TGKLLRTLT--------GHSG 247

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  392 QILCCAYNANGTIFVTGSSDSNARVWSAskpnlddaeQPTHELDVLRGHENDVNYVQFSgcavaPKSSTadalkedsypk 471
Cdd:COG2319    248 SVRSVAFSPDGRLLASGSADGTVRLWDL---------ATGELLRTLTGHSGGVNSVAFS-----PDGKL----------- 302

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  472 fknswfchdnIVTCSRDGSAIIWTPRSrkfhGKSGRWMKGYHlkvpppplppqpprggprqrflptpRGVNMIIWSLDNR 551
Cdd:COG2319    303 ----------LASGSDDGTVRLWDLAT----GKLLRTLTGHT-------------------------GAVRSVAFSPDGK 343

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063707112  552 FVLAAIMDCRICVWNAADGSLVHCLTGHSESSYVLDVHPFNPRIAmSAGYDGKTIIWDI 610
Cdd:COG2319    344 TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA-SGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
232-643 1.94e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 187.43  E-value: 1.94e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  232 LRGHRNAVYCAIFDRSGRYVITGSDDRLVKIWSMETALCLASCRGHEGDITDLAVSSNNALVASASNDFVIRVWRLPDGM 311
Cdd:COG2319     74 LLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  312 PISVLRGHTGAVTAIAFSP--RqasvyQLLSSSDDGTCRIWDARysqwlpriyvpspsdanTGESTFTSsnTGSTSnasq 389
Cdd:COG2319    154 LLRTLTGHSGAVTSVAFSPdgK-----LLASGSDDGTVRLWDLA-----------------TGKLLRTL--TGHTG---- 205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  390 shQILCCAYNANGTIFVTGSSDSNARVWSASKPNLddaeqptheLDVLRGHENDVNYVQFSgcavaPKSSTadalkedsy 469
Cdd:COG2319    206 --AVRSVAFSPDGKLLASGSADGTVRLWDLATGKL---------LRTLTGHSGSVRSVAFS-----PDGRL--------- 260

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  470 pkfknswfchdnIVTCSRDGSAIIWTPRSrkfhGKSGRWMKGYhlkvpppplppqpprggprqrflptPRGVNMIIWSLD 549
Cdd:COG2319    261 ------------LASGSADGTVRLWDLAT----GELLRTLTGH-------------------------SGGVNSVAFSPD 299

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  550 NRFVLAAIMDCRICVWNAADGSLVHCLTGHSESSYVLDVHPFNPRIAmSAGYDGKTIIWDIWEGIPIKVYEIGRFKLVDG 629
Cdd:COG2319    300 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLA-SGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378

                          410
                   ....*....|....*
gi 1063707112  630 KFSQDGTSIVL-SDD 643
Cdd:COG2319    379 AFSPDGRTLASgSAD 393
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1400-1529 6.89e-46

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 161.35  E-value: 6.89e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112 1400 GETSLHSPWEFDNPEfpWEKSTIEDERREKLLSLFAGLVKSISKHQDSYGIQKLNEAAQKMDFCNRFPVPLYPELIHERL 1479
Cdd:cd05529      1 LYNPLSSEWELFDPG--WEQPHIRDEERERLISGLDKLLLSLQLEIAEYFEYPVDLRAWYPDYWNRVPVPMDLETIRSRL 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1063707112 1480 ENQYYRSIESFKHDVDAMLSNAELYFVRSAHMLSKIKRLRDKLTKTLRKL 1529
Cdd:cd05529     79 ENRYYRSLEALRHDVRLILSNAETFNEPNSEIAKKAKRLSDWLLRILSSL 128
WD40 COG2319
WD40 repeat [General function prediction only];
232-656 7.85e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.39  E-value: 7.85e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  232 LRGHRNAVYCAIFDRSGRYVITGSDDRLVKIWSMETALCLASCRGHEGDITDLAVSSNNALVASASNDFVIRVWRLPDGM 311
Cdd:COG2319     32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  312 PISVLRGHTGAVTAIAFSPRQAsvyQLLSSSDDGTCRIWDARysqwlpriyvpspsdanTGESTFTSSntgstsnaSQSH 391
Cdd:COG2319    112 LLRTLTGHTGAVRSVAFSPDGK---TLASGSADGTVRLWDLA-----------------TGKLLRTLT--------GHSG 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  392 QILCCAYNANGTIFVTGSSDSNARVWSASKPNLddaeqptheLDVLRGHENDVNYVQFSgcavaPKSSTadalkedsypk 471
Cdd:COG2319    164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL---------LRTLTGHTGAVRSVAFS-----PDGKL----------- 218

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  472 fknswfchdnIVTCSRDGSAIIWTPRSrkfhGKSGRWMKGYHlkvpppplppqpprggprqrflptpRGVNMIIWSLDNR 551
Cdd:COG2319    219 ----------LASGSADGTVRLWDLAT----GKLLRTLTGHS-------------------------GSVRSVAFSPDGR 259

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  552 FVLAAIMDCRICVWNAADGSLVHCLTGHSESSYVLDVHPFNPRIAmSAGYDGKTIIWDIWEGIPIKVYEIGRFKLVDGKF 631
Cdd:COG2319    260 LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLA-SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338

                          410       420
                   ....*....|....*....|....*
gi 1063707112  632 SQDGTSIVLSDDVGQIYFLNTGQGE 656
Cdd:COG2319    339 SPDGKTLASGSDDGTVRLWDLATGE 363
WD40 COG2319
WD40 repeat [General function prediction only];
229-569 4.07e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.08  E-value: 4.07e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  229 IKKLRGHRNAVYCAIFDRSGRYVITGSDDRLVKIWSMETALCLASCRGHEGDITDLAVSSNNALVASASNDFVIRVWRLP 308
Cdd:COG2319    155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  309 DGMPISVLRGHTGAVTAIAFSP--RqasvyQLLSSSDDGTCRIWdarysqwlpriyvpspsDANTGESTFTSSntgstsn 386
Cdd:COG2319    235 TGKLLRTLTGHSGSVRSVAFSPdgR-----LLASGSADGTVRLW-----------------DLATGELLRTLT------- 285

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  387 aSQSHQILCCAYNANGTIFVTGSSDSNARVWSASKPNLddaeqptheLDVLRGHENDVNYVQFSgcavaPKSSTadalke 466
Cdd:COG2319    286 -GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL---------LRTLTGHTGAVRSVAFS-----PDGKT------ 344

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  467 dsypkfknswfchdnIVTCSRDGSAIIWTPRSRKfhgksgrwmkgyhlkvpppplppqpprggPRQRFLPTPRGVNMIIW 546
Cdd:COG2319    345 ---------------LASGSDDGTVRLWDLATGE-----------------------------LLRTLTGHTGAVTSVAF 380

                          330       340
                   ....*....|....*....|...
gi 1063707112  547 SLDNRFVLAAIMDCRICVWNAAD 569
Cdd:COG2319    381 SPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 223-494 5.39e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 153.26  E-value: 5.39e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  223 VQKMQNIKKLRGHRNAVYCAIFDRSGRYVITGSDDRLVKIWSMETALCLASCRGHEGDITDLAVSSNNALVASASNDFVI 302
Cdd:cd00200     80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  303 RVWRLPDGMPISVLRGHTGAVTAIAFSPRQasvYQLLSSSDDGTCRIWDARYSQWLpriyvpspsdantgeSTFTSSNtg 382
Cdd:cd00200    160 KLWDLRTGKCVATLTGHTGEVNSVAFSPDG---EKLLSSSSDGTIKLWDLSTGKCL---------------GTLRGHE-- 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  383 stsnasqsHQILCCAYNANGTIFVTGSSDSNARVWSASKPNlddaeqpthELDVLRGHENDVNYVQFSgcavaPKSSTad 462
Cdd:cd00200    220 --------NGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE---------CVQTLSGHTNSVTSLAWS-----PDGKR-- 275

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1063707112  463 alkedsypkfknswfchdnIVTCSRDGSAIIW 494
Cdd:cd00200    276 -------------------LASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
244-656 2.05e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 131.57  E-value: 2.05e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  244 FDRSGRYVITGSDDRLVKIWSMETALCLASCRGHEGDITDLAVSSNNALVASASNDFVIRVWRLPDGMPISVLRGHTGAV 323
Cdd:COG2319      2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  324 TAIAFSPRQAsvyQLLSSSDDGTCRIWDArysqwlpriyvpspsdantgestftssNTGSTSNASQSHQ--ILCCAYNAN 401
Cdd:COG2319     82 LSVAFSPDGR---LLASASADGTVRLWDL---------------------------ATGLLLRTLTGHTgaVRSVAFSPD 131

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  402 GTIFVTGSSDSNARVWsaskpNLDDAEqpthELDVLRGHENDVNYVQFSgcavaPKSSTadalkedsypkfknswfchdn 481
Cdd:COG2319    132 GKTLASGSADGTVRLW-----DLATGK----LLRTLTGHSGAVTSVAFS-----PDGKL--------------------- 176

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  482 IVTCSRDGSAIIWTPRSrkfhGKSGRWMKGYhlkvpppplppqpprggprqrflptPRGVNMIIWSLDNRFVLAAIMDCR 561
Cdd:COG2319    177 LASGSDDGTVRLWDLAT----GKLLRTLTGH-------------------------TGAVRSVAFSPDGKLLASGSADGT 227

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  562 ICVWNAADGSLVHCLTGHSESSYVLDVHPFNPRIAmSAGYDGKTIIWDIWEGIPIKVYEIGRFKLVDGKFSQDGTSIVLS 641
Cdd:COG2319    228 VRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLA-SGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASG 306

                          410
                   ....*....|....*
gi 1063707112  642 DDVGQIYFLNTGQGE 656
Cdd:COG2319    307 SDDGTVRLWDLATGK 321
WD40 COG2319
WD40 repeat [General function prediction only];
227-353 4.96e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 127.33  E-value: 4.96e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  227 QNIKKLRGHRNAVYCAIFDRSGRYVITGSDDRLVKIWSMETALCLASCRGHEGDITDLAVSSNNALVASASNDFVIRVWR 306
Cdd:COG2319    279 ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1063707112  307 LPDGMPISVLRGHTGAVTAIAFSPRQAsvyQLLSSSDDGTCRIWDAR 353
Cdd:COG2319    359 LATGELLRTLTGHTGAVTSVAFSPDGR---TLASGSADGTVRLWDLA 402
BROMO smart00297
bromo domain;
1425-1529 5.11e-18

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 80.79  E-value: 5.11e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  1425 ERREKLLSLFAGLVKSISKHQDSYGIQKLNEAAQKMDFCNRFPVPLYPELIHERLENQYYRSIESFKHDVDAMLSNAELY 1504
Cdd:smart00297    3 KLQKKLQELLKAVLDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTY 82

                            90       100
                    ....*....|....*....|....*
gi 1063707112  1505 FVRSAHMLSKIKRLRDKLTKTLRKL 1529
Cdd:smart00297   83 NGPDSEVYKDAKKLEKFFEKKLREL 107
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 390-659 2.22e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 2.22e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  390 SHQILCCAYNANGTIFVTGSSDSNARVWsaskpNLDDAEQPTheldVLRGHENDVNYVqfsgcavapksstadalkedsy 469
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGSGDGTIKVW-----DLETGELLR----TLKGHTGPVRDV---------------------- 57

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  470 pkfknSWFCHDN-IVTCSRDGSAIIWTPRSrkfhGKSGRWMKGyHLKvpppplppqpprggprqrflptprGVNMIIWSL 548
Cdd:cd00200     58 -----AASADGTyLASGSSDKTIRLWDLET----GECVRTLTG-HTS------------------------YVSSVAFSP 103

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  549 DNRFVLAAIMDCRICVWNAADGSLVHCLTGHSESSYVLDVHPFNPRIAmSAGYDGKTIIWDIWEGIPIKVYE--IGRFKL 626
Cdd:cd00200    104 DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVA-SSSQDGTIKLWDLRTGKCVATLTghTGEVNS 182

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1063707112  627 VdgKFSQDGTSIVLSDDVGQIYFLNTGQGESQK 659
Cdd:cd00200    183 V--AFSPDGEKLLSSSSDGTIKLWDLSTGKCLG 213
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 227-306 3.81e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.84  E-value: 3.81e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  227 QNIKKLRGHRNAVYCAIFDRSGRYVITGSDDRLVKIWSMETALCLASCRGHEGDITDLAVSSNNALVASASNDFVIRVWR 306
Cdd:cd00200    210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 309-351 2.93e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 2.93e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1063707112   309 DGMPISVLRGHTGAVTAIAFSPRQasvYQLLSSSDDGTCRIWD 351
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDG---KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
310-351 3.30e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 3.30e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1063707112  310 GMPISVLRGHTGAVTAIAFSPRQAsvyQLLSSSDDGTCRIWD 351
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGK---LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 225-264 3.46e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 3.46e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1063707112   225 KMQNIKKLRGHRNAVYCAIFDRSGRYVITGSDDRLVKIWS 264
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
226-264 7.53e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 7.53e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1063707112  226 MQNIKKLRGHRNAVYCAIFDRSGRYVITGSDDRLVKIWS 264
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 241-450 1.47e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.17  E-value: 1.47e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  241 CAI-FDRSGRYVITGSDDRLVKIWSMETalCLASCRGHEGDITDLAVSSN----------NALVASASNDFVIRVWRLPD 309
Cdd:PLN00181   487 CAIgFDRDGEFFATAGVNKKIKIFECES--IIKDGRDIHYPVVELASRSKlsgicwnsyiKSQVASSNFEGVVQVWDVAR 564

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  310 GMPISVLRGHTGAVTAIAFSPRQASVyqLLSSSDDGTCRIWDARYSQWLPRIyvpsPSDANTGESTFTSSNTGSTSNASQ 389
Cdd:PLN00181   565 SQLVTEMKEHEKRVWSIDYSSADPTL--LASGSDDGSVKLWSINQGVSIGTI----KTKANICCVQFPSESGRSLAFGSA 638

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  390 SHQI-----------LCCAYNANGTI----------FVTGSSDSNARVWSASKPNLDDAEQPTHEldvLRGHENDVNYVQ 448
Cdd:PLN00181   639 DHKVyyydlrnpklpLCTMIGHSKTVsyvrfvdsstLVSSSTDNTLKLWDLSMSISGINETPLHS---FMGHTNVKNFVG 715


                   ..
gi 1063707112  449 FS 450
Cdd:PLN00181   716 LS 717
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 270-305 2.79e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 2.79e-06
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1063707112   270 CLASCRGHEGDITDLAVSSNNALVASASNDFVIRVW 305
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
270-305 9.55e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 9.55e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1063707112  270 CLASCRGHEGDITDLAVSSNNALVASASNDFVIRVW 305
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 572-656 1.43e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.87  E-value: 1.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  572 LVHCLTGHSESSYVLDVHPFNPRIAmSAGYDGKTIIWDIWEGIPIKVYEIGRFKLVDGKFSQDGTSIVLSDDVGQIYFLN 651
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGKLLA-TGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79


                   ....*
gi 1063707112  652 TGQGE 656
Cdd:cd00200     80 LETGE 84
WD40 COG2319
WD40 repeat [General function prediction only];
223-267 3.80e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 3.80e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1063707112  223 VQKMQNIKKLRGHRNAVYCAIFDRSGRYVITGSDDRLVKIWSMET 267
Cdd:COG2319    359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 1461-1505 4.71e-05

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 43.46  E-value: 4.71e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1063707112 1461 DFCNRFPVPLYPELIHERLENQYYRSIESFKHDVDAMLSNAELYF 1505
Cdd:pfam00439   28 DYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYN 72
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 1425-1526 1.25e-04

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 42.74  E-value: 1.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112 1425 ERREKLLSLFAGLVkSISKHQDSYGIQKlneaaQKMDFcnrfpvplypELIHERLENQYYRSIESFKHDVDAMLSNAELY 1504
Cdd:cd04369     14 KLKRDLSEPFLEPV-DPKEAPDYYEVIK-----NPMDL----------STIKKKLKNGEYKSLEEFEADVRLIFSNAKTY 77

                           90       100
                   ....*....|....*....|..
gi 1063707112 1505 FVRSAHMLSKIKRLRDKLTKTL 1526
Cdd:cd04369     78 NGPGSPIYKDAKKLEKLFEKLL 99
PTZ00420 PTZ00420
coronin; Provisional
 275-351 8.08e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.79  E-value: 8.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  275 RGHEGDITDLAVSS-NNALVASASNDFVIRVWRLPDG--------MPISVLRGHTGAVTAIAFSPrqASVYQLLSSSDDG 345
Cdd:PTZ00420    71 KGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIPHNdesvkeikDPQCILKGHKKKISIIDWNP--MNYYIMCSSGFDS 148


                   ....*.
gi 1063707112  346 TCRIWD 351
Cdd:PTZ00420   149 FVNIWD 154
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 569-609 2.82e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 2.82e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1063707112   569 DGSLVHCLTGHSESSYVLDVHPFNPRIAmSAGYDGKTIIWD 609
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLA-SGSDDGTIKLWD 40
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 775-921 2.86e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 42.34  E-value: 2.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  775 HEVLSDDNDSEYNAEVSSDGARASPCSNSSNELECSSEDSDVENIHESSYHWKRRRKHPKVNVSTSSG----RRDKRILD 850
Cdd:PTZ00108  1218 SNSSGSDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPpppsKRPDGESN 1297

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063707112  851 ENDSSNSGIKRTKNRRI------------------VVKASKRKHSDVKASRPQRAAAQNARSLLSKISGSSSDEVDDDND 912
Cdd:PTZ00108  1298 GGSKPSSPTKKKVKKRLegslaalkkkkksekktaRKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSE 1377


                   ....*....
gi 1063707112  913 SSNSESDRS 921
Cdd:PTZ00108  1378 DEDDEDDED 1386
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 390-418 3.40e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.52  E-value: 3.40e-03
                            10        20
                    ....*....|....*....|....*....
gi 1063707112   390 SHQILCCAYNANGTIFVTGSSDSNARVWS 418
Cdd:smart00320   12 TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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