|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
162-837 |
2.90e-143 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 446.84 E-value: 2.90e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 162 ALKAFREKLPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEisslRGADCNIICTQPRRISAISVASRISA 241
Cdd:COG1643 2 SLITYPPDLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELG----WGAGGRIGMLEPRRLAARAAAERMAE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 242 ERGESIGESVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPR-RPDL 320
Cdd:COG1643 78 ELGEPVGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 321 RLILMSATINADMFSTYFGNSPTMHIPGFTFPVaelfleDVleksRYnikssdsgnyqgssRGRRRESEskkdDLttlfe 400
Cdd:COG1643 158 KLLVMSATLDAERFARLLGDAPVIESSGRTYPV------EV----RY--------------RPLPADER----DL----- 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 401 didinshyksyssatrnsleawsgaqidVDLVEATIEHICRlEGGGAILVFLTGWDEI---SKLLEKINMNNFLgdsskf 477
Cdd:COG1643 205 ----------------------------EDAVADAVREALA-EEPGDILVFLPGEREIrrtAEALRGRLPPDTE------ 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 478 lVLPLHGSMPTVNQREIFDRPPPNKRKIVLATNIAESSITIDDVVYVVDCGKAKETSYDALNKVACLLPSWISKASAHQR 557
Cdd:COG1643 250 -ILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQR 328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 558 RGRAGRVQAGVCYRLYPKVIYDAFPQYQLPEIIRTPLQELCLHIKSLQVGSIGSFlaKALQPPDALAVENAIELLKTIGA 637
Cdd:COG1643 329 AGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDL--PFLDPPPARAIADARALLQELGA 406
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 638 LNDVEELTPLGRHLCTLPVDPNIGKMLLIGAIFQCVNPALTIAAALAYRSPfvlplnRKEEADeakryfagdscSDHIAL 717
Cdd:COG1643 407 LDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDP------RRGAAG-----------SDLLAR 469
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 718 LKAYEGYRDAKRggnekdfcwqNFLSPVTLRMMEDMRNQFLDLLSDigfvdkskpnAYNQYSYDMEMISAVLCAGlYP-N 796
Cdd:COG1643 470 LNLWRRLREQQR----------EFLSYLRLREWRDLARQLRRLLGE----------GANEEPADYEAIGLLLALA-YPdR 528
|
650 660 670 680
....*....|....*....|....*....|....*....|....*
gi 1063705874 797 VvqCKRRGKRTAFytkeLG----KVDIHPGSVnarvnLFSLPYLV 837
Cdd:COG1643 529 I--ARRRGEGGRY----LLargrGAALFPGSP-----LAKKEWLV 562
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
148-855 |
2.25e-119 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 394.14 E-value: 2.25e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 148 KERQEKLKATESVKALKAFR------EKLPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEisslRGADCN 221
Cdd:TIGR01967 38 KFRERIDAACDKVEARRQAVpeirypDNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELG----RGSHGL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 222 IICTQPRRISAISVASRISAERGESIGESVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGM 301
Cdd:TIGR01967 114 IGHTQPRRLAARTVAQRIAEELGTPLGEKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 302 NEDFLLIILRDLLPRRPDLRLILMSATINADMFSTYFGNSPTMHIPGFTFPVAelfledvlekSRYnikssdsgnyqgss 381
Cdd:TIGR01967 194 NIDFLLGYLKQLLPRRPDLKIIITSATIDPERFSRHFNNAPIIEVSGRTYPVE----------VRY-------------- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 382 rgRRRESESKKDDLTTLfedidinshyksyssatrnsleawsgaqidvDLVEATIEHICRlEGGGAILVFLTGWDEISKL 461
Cdd:TIGR01967 250 --RPLVEEQEDDDLDQL-------------------------------EAILDAVDELFA-EGPGDILIFLPGEREIRDA 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 462 LEKINMNNFLGDSskflVLPLHGSMPTVNQREIFDrpPPNKRKIVLATNIAESSITIDDVVYVVDCGKAKETSYDALNKV 541
Cdd:TIGR01967 296 AEILRKRNLRHTE----ILPLYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKV 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 542 ACLLPSWISKASAHQRRGRAGRVQAGVCYRLYPKVIYDAFPQYQLPEIIRTPLQELCLHIKSLQVGSIGSFlaKALQPPD 621
Cdd:TIGR01967 370 QRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAAF--PFIEAPD 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 622 ALAVENAIELLKTIGALNDVE---ELTPLGRHLCTLPVDPNIGKMLLIGAIFQCVNPALTIAAALAYRSPFVLPLNRKEE 698
Cdd:TIGR01967 448 PRAIRDGFRLLEELGALDDDEaepQLTPIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRERPMEKQQA 527
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 699 ADEAKRYFAgDSCSDHIALLKAYEGY---RDAKRGGNEKDFCWQNFLSPVTLRMMEDMRNQFLDLLSDIGFVDKSKPNAY 775
Cdd:TIGR01967 528 ADQAHARFK-DPRSDFLSRVNLWRHIeeqRQALSANQFRNACRKQYLNYLRVREWQDIYRQLTQVVKELGLKLNEEPADY 606
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 776 NQysydmemISAVLCAGLYPNVVQckRRGKRTafYTKELG-KVDIHPGSvnarvNLFSLP--YLVYSEKVKTTSVYIRDS 852
Cdd:TIGR01967 607 DA-------IHKALLSGLLSQIGM--KDEKHE--YDGARGrKFHIFPGS-----PLFKKPpkWVMAAELVETSKLYARLV 670
|
...
gi 1063705874 853 TNI 855
Cdd:TIGR01967 671 AKI 673
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
125-831 |
2.53e-109 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 366.69 E-value: 2.53e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 125 LKRPDSASKLPDSLEKEkfsfALKERQEKLKATESVKALKaFREKLPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLP 204
Cdd:PRK11131 33 IKNPDAQQAIFQEIAKE----IAQAAQRVLLREAARPEIT-YPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 205 QFILEeeissL-RGADCNIICTQPRRISAISVASRISAERGESIGESVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDP 283
Cdd:PRK11131 108 KICLE-----LgRGVKGLIGHTQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDR 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 284 NLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLILMSATINADMFSTYFGNSPTMHIPGFTFPVaelfleDVle 363
Cdd:PRK11131 183 LLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPV------EV-- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 364 ksRYNIKSSDsgnyqgssrgrrrESESKKDDLTTLFEDIDinshyksyssatrnsleawsgaqidvdlveatieHICRlE 443
Cdd:PRK11131 255 --RYRPIVEE-------------ADDTERDQLQAIFDAVD----------------------------------ELGR-E 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 444 GGGAILVFLTGWDEISKLLEKINMNNfLGDSSkflVLPLHGSMPTVNQREIFDrpPPNKRKIVLATNIAESSITIDDVVY 523
Cdd:PRK11131 285 GPGDILIFMSGEREIRDTADALNKLN-LRHTE---ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKY 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 524 VVDCGKAKETSYDALNKVACLLPSWISKASAHQRRGRAGRVQAGVCYRLYPKVIYDAFPQYQLPEIIRTPLQELCLHIKS 603
Cdd:PRK11131 359 VIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTA 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 604 LQVGSIGSFlaKALQPPDALAVENAIELLKTIGALN-----DVEELTPLGRHLCTLPVDPNIGKMLLIGAIFQCVNPALT 678
Cdd:PRK11131 439 LGLGDIAAF--PFVEAPDKRNIQDGVRLLEELGAITtdeqaSAYKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMI 516
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 679 IAAALAYRSPFVLPLNRKEEADEAKRYFAgDSCSDHIALLKAYEGYRDAKRGGNEKDF---CWQNFLSPVTLRMMEDMRN 755
Cdd:PRK11131 517 ITSALSIQDPRERPMDKQQASDEKHRRFA-DKESDFLAFVNLWNYLQEQQKALSSNQFrrlCRTDYLNYLRVREWQDIYT 595
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063705874 756 QFLDLLSDIGFVDKSKPNAYNQysydmemISAVLCAGLYPNVVQckrrgkrtafytKELGKVDIHpGSVNARVNLF 831
Cdd:PRK11131 596 QLRQVVKELGIPVNSEPAEYRE-------IHTALLTGLLSHIGM------------KDAEKQEYT-GARNARFSIF 651
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
186-346 |
4.61e-94 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 293.60 E-value: 4.61e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 186 NQVLVVSGETGCGKTTQLPQFILEEEISslRGADCNIICTQPRRISAISVASRISAERGESIGESVGYQIRLESKRSDQT 265
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLA--KGGKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 266 RLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLILMSATINADMFSTYFGNSPTMH 345
Cdd:cd17917 79 RIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAPVIH 158
|
.
gi 1063705874 346 I 346
Cdd:cd17917 159 I 159
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
170-688 |
2.63e-81 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 280.50 E-value: 2.63e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEisslrGADCNIICTQPRRISAISVASRISAERGESIGE 249
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLDAP-----GIGGKIIMLEPRRLAARSAAQRLASQLGEAVGQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 250 SVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPR-RPDLRLILMSAT 328
Cdd:TIGR01970 76 TVGYRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSlREDLKILAMSAT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 329 INADMFSTYFGNSPTMHIPGFTFPVaelfledvleKSRYnikssdsgnyqgssRGRRREseskkddlttlfedidinshy 408
Cdd:TIGR01970 156 LDGERLSSLLPDAPVVESEGRSFPV----------EIRY--------------LPLRGD--------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 409 ksyssatrnslEAWsgaqidVDLVEATIEHICRLEgGGAILVFLTGWDEISKLLEKinMNNFLGdsSKFLVLPLHGSMPT 488
Cdd:TIGR01970 191 -----------QRL------EDAVSRAVEHALASE-TGSILVFLPGQAEIRRVQEQ--LAERLD--SDVLICPLYGELSL 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 489 VNQREIFDRPPPNKRKIVLATNIAESSITIDDVVYVVDCGKAKETSYDALNKVACLLPSWISKASAHQRRGRAGRVQAGV 568
Cdd:TIGR01970 249 AAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAGRAGRLEPGV 328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 569 CYRLYPKVIYDAFPQYQLPEIIRTPLQELCLHIksLQVGSIGSFLAKALQPPDALAVENAIELLKTIGALNDVEELTPLG 648
Cdd:TIGR01970 329 CYRLWSEEQHQRLPAQDEPEILQADLSGLALEL--AQWGAKDPSDLRWLDAPPSVALAAARQLLQRLGALDAQGRLTAHG 406
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 1063705874 649 RHLCTLPVDPNIGKMLLIGAIFQCVNPALTIAAALAYRSP 688
Cdd:TIGR01970 407 KAMAALGCHPRLAAMLLSAHSTGLAALACDLAALLEERGL 446
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
170-346 |
4.82e-81 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 259.77 E-value: 4.82e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEISSLRGADCNIICTQPRRISAISVASRISAERGESIGE 249
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVANIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 250 SVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLILMSATI 329
Cdd:cd17985 81 SVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSATL 160
|
170
....*....|....*..
gi 1063705874 330 NADMFSTYFGNSPTMHI 346
Cdd:cd17985 161 NAELFSDYFNSCPVIHI 177
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
426-573 |
3.49e-79 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 254.38 E-value: 3.49e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 426 QIDVDLVEATIEHICRLEGGGAILVFLTGWDEISKLLEKINMNNFLGDSSKFLVLPLHGSMPTVNQREIFDRPPPNKRKI 505
Cdd:cd18791 24 PDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLSPDLGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKV 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063705874 506 VLATNIAESSITIDDVVYVVDCGKAKETSYDALNKVACLLPSWISKASAHQRRGRAGRVQAGVCYRLY 573
Cdd:cd18791 104 VLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
170-346 |
5.35e-79 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 254.38 E-value: 5.35e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEISSLRGADCNIICTQPRRISAISVASRISAERGES--I 247
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSSCRIVCTQPRRISAISVAERVAAERAEScgL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 248 GESVGYQIRLESKRS-DQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLILMS 326
Cdd:cd17981 81 GNSTGYQIRLESRKPrKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160
|
170 180
....*....|....*....|
gi 1063705874 327 ATINADMFSTYFGNSPTMHI 346
Cdd:cd17981 161 ATLNAEKFSDYFNNCPMIHI 180
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
141-346 |
1.81e-74 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 243.97 E-value: 1.81e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 141 EKFSFALKERQE-KLKATESVKALKAFREKLPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEISSLRGAD 219
Cdd:cd17972 29 EQISMDLKNELMyQREQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFIQNDRAAE 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 220 CNIICTQPRRISAISVASRISAERGESIGESVGYQIRLESKR-SDQTRLLFCTTGVLLRRLieDPNLTNVSHLLVDEIHE 298
Cdd:cd17972 109 CNIVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLpRPHASILFCTVGVLLRKL--EAGIRGISHVIVDEIHE 186
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1063705874 299 RGMNEDFLLIILRDLLPRRPDLRLILMSATINADMFSTYFGNSPTMHI 346
Cdd:cd17972 187 RDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
170-346 |
2.57e-70 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 230.83 E-value: 2.57e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEISSLRGADCNIICTQPRRISAISVASRISAERGESIGE 249
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 250 SVGYQIRLESKRSDQ-TRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLILMSAT 328
Cdd:cd17976 81 NVGYQVRLESRPPPRgGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSAT 160
|
170
....*....|....*...
gi 1063705874 329 INADMFSTYFGNSPTMHI 346
Cdd:cd17976 161 GDNQRLSRYFGGCPVVRV 178
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
170-684 |
1.41e-68 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 244.83 E-value: 1.41e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSV-SQNQVLVvSGETGCGKTTQLPQFILEEEISSLRgadcnIICTQPRRISAISVASRISAERGESIG 248
Cdd:PRK11664 4 LPVAAVLPELLTALkTAPQVLL-KAPTGAGKSTWLPLQLLQHGGINGK-----IIMLEPRRLAARNVAQRLAEQLGEKPG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 249 ESVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDL---LprRPDLRLILM 325
Cdd:PRK11664 78 ETVGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVqqgL--RDDLKLLIM 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 326 SATINADMFSTYFGNSPTMHIPGFTFPVAElfledvleksrynikssdsgnyqgssrgrrreseskkddlttlfedidin 405
Cdd:PRK11664 156 SATLDNDRLQQLLPDAPVIVSEGRSFPVER-------------------------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 406 sHYKSYSSATRnsLEawsgaqidvDLVEATIEHICRLEGGgAILVFLTGWDEISKLLEKinMNNFLgdSSKFLVLPLHGS 485
Cdd:PRK11664 186 -RYQPLPAHQR--FD---------EAVARATAELLRQESG-SLLLFLPGVGEIQRVQEQ--LASRV--ASDVLLCPLYGA 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 486 MPTVNQREIFDRPPPNKRKIVLATNIAESSITIDDVVYVVDCGKAKETSYDALNKVACLLPSWISKASAHQRRGRAGRVQ 565
Cdd:PRK11664 249 LSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLE 328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 566 AGVCYRLYPKVIYDAFPQYQLPEIIRTPLQELCLHIksLQVGSIGSFLAKALQPPDALAVENAIELLKTIGALNDVEELT 645
Cdd:PRK11664 329 PGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLEL--LQWGCHDPAQLSWLDQPPAAALAAAKRLLQQLGALDGQGRLT 406
|
490 500 510
....*....|....*....|....*....|....*....
gi 1063705874 646 PLGRHLCTLPVDPNIGKMLLIGAifQCVNPALTIAAALA 684
Cdd:PRK11664 407 ARGRKMAALGNDPRLAAMLVAAK--EDDEAALATAAKLA 443
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
170-346 |
2.50e-68 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 225.09 E-value: 2.50e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEeiSSLRGADCNIICTQPRRISAISVASRISAERGESIGE 249
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDD--CYANGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 250 SVGYQIRLESKRSDQTRLLFCTTGVLLRRLIE-DPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLILMSAT 328
Cdd:cd17987 79 TVGYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAA 158
|
170
....*....|....*...
gi 1063705874 329 INADMFSTYFGNSPTMHI 346
Cdd:cd17987 159 LDVNLFIRYFGSCPVIYI 176
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
170-346 |
1.29e-66 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 220.94 E-value: 1.29e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEISSLRGAD-CNIICTQPRRISAISVASRISAERGESIG 248
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGGTAQkCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 249 ES-----VGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLI 323
Cdd:cd17975 81 PGgknslCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLI 160
|
170 180
....*....|....*....|...
gi 1063705874 324 LMSATINADMFSTYFGNSPTMHI 346
Cdd:cd17975 161 LMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
170-346 |
2.15e-61 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 205.75 E-value: 2.15e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEISslrgadcNIICTQPRRISAISVASRISAERGESIGE 249
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFR-------HIACTQPRRIACISLAKRVAFESLNQYGS 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 250 SVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLILMSATI 329
Cdd:cd17979 74 KVAYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATI 153
|
170
....*....|....*..
gi 1063705874 330 NADMFSTYFGNSPTMHI 346
Cdd:cd17979 154 NIELFSGYFEGAPVVQV 170
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
167-346 |
3.62e-57 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 194.94 E-value: 3.62e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 167 REKLPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEISSLRGAdcNIICTQPRRISAISVASRISAERGES 246
Cdd:cd17973 10 RRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKK--LVACTQPRRVAAMSVAQRVAEEMDVK 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 247 IGESVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLILMS 326
Cdd:cd17973 88 LGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLKLIVMS 167
|
170 180
....*....|....*....|
gi 1063705874 327 ATINADMFSTYFGNSPTMHI 346
Cdd:cd17973 168 ATLDAGKFQKYFDNAPLLKV 187
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
167-347 |
1.98e-56 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 192.31 E-value: 1.98e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 167 REKLPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEISSlRGAdcnIICTQPRRISAISVASRISAERGES 246
Cdd:cd17971 3 RESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTS-RGK---IGCTQPRRVAAMSVAKRVAEEFGCC 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 247 IGESVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLILMS 326
Cdd:cd17971 79 LGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTS 158
|
170 180
....*....|....*....|.
gi 1063705874 327 ATINADMFSTYFGNSPTMHIP 347
Cdd:cd17971 159 ATLDAVKFSQYFYEAPIFTIP 179
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
170-353 |
3.55e-56 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 191.56 E-value: 3.55e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEISslRGADCNIICTQPRRISAISVASRISAERGESIGE 249
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYK--RGKYCNIVVTQPRRIAAISIARRVSQEREWTLGS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 250 SVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPD-LRLILMSAT 328
Cdd:cd17988 79 LVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVKIILMSAT 158
|
170 180
....*....|....*....|....*
gi 1063705874 329 INADMFSTYFGnspTMHIPGFTFPV 353
Cdd:cd17988 159 ISCKEFADYFT---TPNNPAYVFEV 180
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
170-346 |
1.52e-54 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 186.90 E-value: 1.52e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEISSlRGAdcnIICTQPRRISAISVASRISAERGESIGE 249
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTD-YGM---IGCTQPRRVAAMSVAKRVSEEMGVELGE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 250 SVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLILMSATI 329
Cdd:cd17983 77 EVGYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATM 156
|
170
....*....|....*..
gi 1063705874 330 NADMFSTYFGNSPTMHI 346
Cdd:cd17983 157 DADKFADFFGNVPIFTI 173
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
170-346 |
2.41e-52 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 181.01 E-value: 2.41e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEIsslrgADCNII-CTQPRRISAISVASRISAERGESIG 248
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGF-----ARGGMIgITQPRRVAAVSVAKRVAEEMGVELG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 249 ESVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRR-----PDLRLI 323
Cdd:cd17978 76 QLVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSPLKVI 155
|
170 180
....*....|....*....|...
gi 1063705874 324 LMSATINADMFSTYFGNSPTMHI 346
Cdd:cd17978 156 IMSATLDADLFSEYFNGAPVLYI 178
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
170-346 |
3.67e-52 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 180.39 E-value: 3.67e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEISSLRGadcNIICTQPRRISAISVASRISAERGESIGE 249
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGG---KIGCTQPRRVAAMSVAARVAEEMGVKLGN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 250 SVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLILMSATI 329
Cdd:cd17974 78 EVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATM 157
|
170
....*....|....*..
gi 1063705874 330 NADMFSTYFGNSPTMHI 346
Cdd:cd17974 158 DAEKFSAFFDDAPIFRI 174
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
170-350 |
1.23e-50 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 176.51 E-value: 1.23e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEeeiSSLRGADCNIICTQPRRISAISVASRISAERGESIGE 249
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAE---AGWTAGGRVVGCTQPRRVAAVTVAGRVAEEMGAVLGH 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 250 SVGYQIRLESKRSDQ-TRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLILMSAT 328
Cdd:cd17980 78 EVGYCIRFDDCTDPQaTRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASAT 157
|
170 180
....*....|....*....|..
gi 1063705874 329 INADMFSTYFGNSPTMHIPGFT 350
Cdd:cd17980 158 LDAEKFRDFFNQNETNDPSKDT 179
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
170-346 |
2.41e-50 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 174.95 E-value: 2.41e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEisslRGADCNIICTQPRRISAISVASRISAERGESIGE 249
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELG----RGIRGLIGHTQPRRLAARSVAERIAEELKTELGG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 250 SVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLILMSATI 329
Cdd:cd17989 77 AVGYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATI 156
|
170
....*....|....*..
gi 1063705874 330 NADMFSTYFGNSPTMHI 346
Cdd:cd17989 157 DAERFSRHFNNAPIIEV 173
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
170-343 |
1.65e-46 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 164.04 E-value: 1.65e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEeissLRGADCNIICTQPRRISAISVASRISAERGESIGE 249
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAE----LWIAGGKIIVLEPRRVAARAAARRLATLLGEAPGE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 250 SVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLP-RRPDLRLILMSAT 328
Cdd:cd17990 77 TVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAMSAT 156
|
170
....*....|....*
gi 1063705874 329 INADMFSTYFGNSPT 343
Cdd:cd17990 157 LDGDGLAALLPEAPV 171
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
170-342 |
2.06e-43 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 155.98 E-value: 2.06e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEISSLRGADCNII-CTQPRRISAISVASRISAERGESiG 248
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPESDNPGMIgITQPRRVAAVSMAKRVAEELNVF-G 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 249 ESVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPD--------- 319
Cdd:cd17982 80 KEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtvk 159
|
170 180
....*....|....*....|....*..
gi 1063705874 320 -LRLILMSATINADMFS---TYFGNSP 342
Cdd:cd17982 160 pLKLVIMSATLRVEDFTenkLLFPRPP 186
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
170-346 |
9.32e-43 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 153.86 E-value: 9.32e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEISSlRGAdcnIICTQPRRISAISVASRISAERGESIGE 249
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQ-HGM---IGVTQPRRVAAISVAQRVAEEMKCTLGS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 250 SVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLP-----RRPDLRLIL 324
Cdd:cd17984 77 KVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQekspnRKEHLKVVV 156
|
170 180
....*....|....*....|..
gi 1063705874 325 MSATINADMFSTYFGNSPTMHI 346
Cdd:cd17984 157 MSATLELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
170-346 |
1.08e-33 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 127.63 E-value: 1.08e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSVSQNQVLVVSGETGCGKTTQLPQFILEEEISsLRGADCNIICTQPRRISAISVASRISAERGESIGE 249
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLS-AHYQHGVVVCTQVHKQTAVWLALRVADEMDVNIGH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 250 SVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLILMSATI 329
Cdd:cd17977 80 EVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCPH 159
|
170
....*....|....*..
gi 1063705874 330 NADMFSTYFGNSPTMHI 346
Cdd:cd17977 160 LSSKLLSYYGNVPLIEV 176
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
628-717 |
4.92e-29 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 111.56 E-value: 4.92e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 628 AIELLKTIGALNDVEELTPLGRHLCTLPVDPNIGKMLLIGAIFQCVNPALTIAAALAYRSPFVLPLN------------- 694
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaarrr 80
|
90 100
....*....|....*....|....
gi 1063705874 695 RKEEADEAKRYFAG-DSCSDHIAL 717
Cdd:pfam04408 81 RRAADEKARAKFARlDLEGDHLTL 104
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
170-346 |
5.63e-28 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 111.14 E-value: 5.63e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 170 LPAFKMKEEFLNSV-SQNQVLVVSGETGCGKTTQLPQFILEEEISsLRGADCNIICTQPRRISAISVASRISAERGESIG 248
Cdd:cd17986 1 LPIWAAKFTFLEQLeSPSGIVLVSGEPGSGKSTQVPQWCAEFALS-RGFQKGQVTVTQPHPLAARSLALRVADEMDLNLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 249 ESVGYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRRPDLRLILMSAT 328
Cdd:cd17986 80 HEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTSP 159
|
170
....*....|....*...
gi 1063705874 329 INADMFSTYFGNSPTMHI 346
Cdd:cd17986 160 ALEPKLRAFWGNPPVVHV 177
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
183-352 |
1.97e-24 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 101.80 E-value: 1.97e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 183 VSQNQVLVVSGETGCGKTTQLPQFILEeeiSSLRGADCNIICTQPRRISAISVASRISAERGESIGESVGY------QIR 256
Cdd:smart00487 21 LSGLRDVILAAPTGSGKTLAALLPALE---ALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLyggdskREQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 257 LESKRSDQTRLLFCTTGVLLRRLIEDP-NLTNVSHLLVDEIHERGmNEDFLLIILRDLLPRRPDLRLILMSATI--NADM 333
Cdd:smart00487 98 LRKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLL-DGGFGDQLEKLLKLLPKNVQLLLLSATPpeEIEN 176
|
170
....*....|....*....
gi 1063705874 334 FSTYFGNSPTMHIPGFTFP 352
Cdd:smart00487 177 LLELFLNDPVFIDVGFTPL 195
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
635-718 |
5.19e-24 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 96.57 E-value: 5.19e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 635 IGALNDVEELTPLGRHLCTLPVDPNIGKMLLIGAIFQCVNPALTIAAALAYRSPFvlPLNRKEEADEAKRYFAGDScSDH 714
Cdd:smart00847 2 LGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPE-SDH 78
|
....
gi 1063705874 715 IALL 718
Cdd:smart00847 79 LTLL 82
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
785-867 |
6.82e-21 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 87.69 E-value: 6.82e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 785 ISAVLCAGLYPNVVQCKRRGKR-TAFYTKElgKVDIHPGSVNARVNLFSLPYLVYSEKVKTTSVYIRDSTNISDYALLMF 863
Cdd:pfam07717 1 LRAALAAGLYPNVARRDPKGKGyTTLSDNQ--RVFIHPSSVLFNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLF 78
|
....
gi 1063705874 864 GGNL 867
Cdd:pfam07717 79 APHI 82
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
456-563 |
1.99e-16 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 74.94 E-value: 1.99e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 456 DEISKLLEKINMNnflgdsskflVLPLHGSMPTVNQREIFDRPPPNKRKIVLATNIAESSITIDDVVYVVDCGkaketsy 535
Cdd:smart00490 1 EELAELLKELGIK----------VARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYD------- 63
|
90 100
....*....|....*....|....*...
gi 1063705874 536 dalnkvacllpSWISKASAHQRRGRAGR 563
Cdd:smart00490 64 -----------LPWSPASYIQRIGRAGR 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
434-564 |
5.53e-16 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 74.55 E-value: 5.53e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 434 ATIEHICRLEGGGAILVFLTGWDEISKllekinmnNFLGDSSKFLVLPLHGSMPTVNQREIFDRPPPNKRKIVLATNIAE 513
Cdd:pfam00271 4 EALLELLKKERGGKVLIFSQTKKTLEA--------ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAE 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1063705874 514 SSITIDDVVYVVDCGkaketsydalnkvacllPSWiSKASAHQRRGRAGRV 564
Cdd:pfam00271 76 RGLDLPDVDLVINYD-----------------LPW-NPASYIQRIGRAGRA 108
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
186-573 |
2.05e-15 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 80.79 E-value: 2.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 186 NQVLVVSGETGCGKTTQLPQFIL--------EEEISSLRG--ADCNIICTQPR----RISAISVASRISAERGESIGESV 251
Cdd:PHA02653 179 RKPVVLTGGTGVGKTSQVPKLLLwfnylfggFDNLDKIDPnfIERPIVLSLPRvalvRLHSITLLKSLGFDEIDGSPISL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 252 GY---QIRLESKRSDQTRLLFCTTGVLLRrliedpNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPRrpdLR-LILMSA 327
Cdd:PHA02653 259 KYgsiPDELINTNPKPYGLVFSTHKLTLN------KLFDYGTVIIDEVHEHDQIGDIIIAVARKHIDK---IRsLFLMTA 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 328 TINADM--FSTYFGNSPTMHIPGFT-FPVAELFLedvleKSRYNIKSsdsgnyqgssrgRRRESESKKDDLttlfedidi 404
Cdd:PHA02653 330 TLEDDRdrIKEFFPNPAFVHIPGGTlFPISEVYV-----KNKYNPKN------------KRAYIEEEKKNI--------- 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 405 nshyksySSATRNsleawsgaqidvdlveatiehiCRLEGGGAILVFL---TGWDEISKLLEKINmnnflgdsSKFLVLP 481
Cdd:PHA02653 384 -------VTALKK----------------------YTPPKGSSGIVFVasvSQCEEYKKYLEKRL--------PIYDFYI 426
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 482 LHGSMPTVNQ--REIFDRPPPNkrkIVLATNIAESSITIDDVVYVVDCGK--------AKETsydalnkvacllpsWISK 551
Cdd:PHA02653 427 IHGKVPNIDEilEKVYSSKNPS---IIISTPYLESSVTIRNATHVYDTGRvyvpepfgGKEM--------------FISK 489
|
410 420
....*....|....*....|..
gi 1063705874 552 ASAHQRRGRAGRVQAGVCYRLY 573
Cdd:PHA02653 490 SMRTQRKGRVGRVSPGTYVYFY 511
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
189-328 |
1.32e-12 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 66.27 E-value: 1.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 189 LVVSGETGCGKTTQLPQFILEEeissLRGADCNIICTQPRRISAISVASRISAERGESIgeSVGYQIR------LESKRS 262
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLL----LLKKGKKVLVLVPTKALALQTAERLRELFGPGI--RVAVLVGgssaeeREKNKL 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063705874 263 DQTRLLFCTTGVLLRRLIED--PNLTNVSHLLVDEIHERGMNEDFLLIILRDLLPR-RPDLRLILMSAT 328
Cdd:cd00046 78 GDADIIIATPDMLLNLLLREdrLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAgLKNAQVILLSAT 146
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
177-332 |
1.22e-10 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 61.10 E-value: 1.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 177 EEFLNSVSQNQVLVVSGETGCGKTT--QLPqfILEEEISSLRGADCNIICtqPRRISAISVASRISaERGESIGESV--- 251
Cdd:pfam00270 5 AEAIPAILEGRDVLVQAPTGSGKTLafLLP--ALEALDKLDNGPQALVLA--PTRELAEQIYEELK-KLGKGLGLKVasl 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 252 --GYQIRLESKRSDQTRLLFCTTGVLLRRLIEDPNLTNVSHLLVDEIHErgMNEDFLLIILRDLLPR-RPDLRLILMSAT 328
Cdd:pfam00270 80 lgGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHR--LLDMGFGPDLEEILRRlPKKRQILLLSAT 157
|
....
gi 1063705874 329 INAD 332
Cdd:pfam00270 158 LPRN 161
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
189-347 |
1.89e-07 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 52.26 E-value: 1.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 189 LVVSGETGCGKTtqlpqFILEEEI-SSLRGADCNIICTQPRRisaiSVASRISA---ERGESIGESVGYQIRLES---KR 261
Cdd:cd17921 20 VLVSAPTSSGKT-----LIAELAIlRALATSGGKAVYIAPTR----ALVNQKEAdlrERFGPLGKNVGLLTGDPSvnkLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 262 SDQTRLLFCTT---GVLLRRLiEDPNLTNVSHLLVDEIH-----ERGMnedfLLIILRDLLPRR-PDLRLILMSATI-NA 331
Cdd:cd17921 91 LAEADILVATPeklDLLLRNG-GERLIQDVRLVVVDEAHligdgERGV----VLELLLSRLLRInKNARFVGLSATLpNA 165
|
170
....*....|....*.
gi 1063705874 332 DMFSTYFGNSPTMHIP 347
Cdd:cd17921 166 EDLAEWLGVEDLIRFD 181
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
179-338 |
4.34e-06 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 48.37 E-value: 4.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 179 FLNSVSQNQVLVVSGETGCGKTtqlpqfiLEEEISSLRgadcNIICtqpRRISAISVASRIS--AERG---ESIGESVGY 253
Cdd:cd18026 26 SLPGLLEGRNLVYSLPTSGGKT-------LVAEILMLK----RLLE---RRKKALFVLPYVSivQEKVdalSPLFEELGF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 254 QI--------RLESKRSDQTRLLFCT---TGVLLRRLIEDPNLTNVSHLLVDEIH-----ERGMNEDFLLIILrdLLPRR 317
Cdd:cd18026 92 RVegyagnkgRSPPKRRKSLSVAVCTiekANSLVNSLIEEGRLDELGLVVVDELHmlgdgHRGALLELLLTKL--LYAAQ 169
|
170 180 190
....*....|....*....|....*....|.
gi 1063705874 318 PDLRLILMSATI----------NADMFSTYF 338
Cdd:cd18026 170 KNIQIVGMSATLpnleelaswlRAELYTTNF 200
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
504-563 |
1.70e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 40.77 E-value: 1.70e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 504 KIVLATNIAESSITIDDVVYVVDCGKaketsydalnkvacllpsWISKASAHQRRGRAGR 563
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFDP------------------PSSAASYIQRVGRAGR 65
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
189-332 |
5.91e-03 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 38.96 E-value: 5.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 189 LVVSGETGCGKTTQ--LP--QFILEEEISSLRGADCNIICtqPRR-----ISaiSVASRISAERGESI-----GESVGYQ 254
Cdd:cd00268 30 VIGQAQTGSGKTLAflLPilEKLLPEPKKKGRGPQALVLA--PTRelamqIA--EVARKLGKGTGLKVaaiygGAPIKKQ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063705874 255 IRLESKRSDqtrLLFCTTGvllrRLIE-----DPNLTNVSHLLVDE---IHERGMNEDfLLIILRDLLPRRpdlRLILMS 326
Cdd:cd00268 106 IEALKKGPD---IVVGTPG----RLLDliergKLDLSNVKYLVLDEadrMLDMGFEED-VEKILSALPKDR---QTLLFS 174
|
....*.
gi 1063705874 327 ATINAD 332
Cdd:cd00268 175 ATLPEE 180
|
|
| |
