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Conserved domains on  [gi|1063684659|ref|NP_001322630|]
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IQ-domain 30 [Arabidopsis thaliana]

Protein Classification

IQ and DUF4005 domain-containing protein( domain architecture ID 10635720)

IQ and DUF4005 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF4005 super family cl16148
Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing ...
485-551 4.95e-11

Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing putative calmodulin-binding proteins.


The actual alignment was detected with superfamily member pfam13178:

Pssm-ID: 404128  Cd Length: 97  Bit Score: 59.56  E-value: 4.95e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063684659 485 IPSYMQATKSAKAKLRLQgsSSPRQLGTTE------KASRRYSLPSSGNSAKITSHSPKTRVSNSSGKSGNKT 551
Cdd:pfam13178  27 LPNYMAATESAKAKLRSQ--SAPRQRPSTPerdrsgSAAKRLSLPAPSPNGKGSSYGPRARQVQASYKHSLRS 97
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
107-129 1.47e-05

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


:

Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 41.93  E-value: 1.47e-05
                           10        20
                   ....*....|....*....|...
gi 1063684659  107 QQEIAAVTVQAAYRGYLARRAFK 129
Cdd:smart00015   1 RLTRAAIIIQAAWRGYLARKRYK 23
PTZ00341 super family cl31759
Ring-infected erythrocyte surface antigen; Provisional
321-446 3.49e-03

Ring-infected erythrocyte surface antigen; Provisional


The actual alignment was detected with superfamily member PTZ00341:

Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 40.54  E-value: 3.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684659  321 QSVEPLPSMDNPQVDLEKVKRGLRKVHNPVVENSiqpQLVPQIAVEKPNGSLEESVNAFDEEKEDEVAETVVQQPEELIQ 400
Cdd:PTZ00341  1009 ENVEENIEENVEEYDEENVEEVEENVEEYDEENV---EEIEENAEENVEENIEENIEEYDEENVEEIEENIEENIEENVE 1085
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1063684659  401 THTPLGTNESLDSTLVNQIEESEENVMAEEKEDVKE--ERTPKQNHKE 446
Cdd:PTZ00341  1086 ENVEENVEEIEENVEENVEENAEENAEENAEENAEEydDENPEEHNEE 1133
 
Name Accession Description Interval E-value
DUF4005 pfam13178
Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing ...
485-551 4.95e-11

Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing putative calmodulin-binding proteins.


Pssm-ID: 404128  Cd Length: 97  Bit Score: 59.56  E-value: 4.95e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063684659 485 IPSYMQATKSAKAKLRLQgsSSPRQLGTTE------KASRRYSLPSSGNSAKITSHSPKTRVSNSSGKSGNKT 551
Cdd:pfam13178  27 LPNYMAATESAKAKLRSQ--SAPRQRPSTPerdrsgSAAKRLSLPAPSPNGKGSSYGPRARQVQASYKHSLRS 97
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
107-129 1.47e-05

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 41.93  E-value: 1.47e-05
                           10        20
                   ....*....|....*....|...
gi 1063684659  107 QQEIAAVTVQAAYRGYLARRAFK 129
Cdd:smart00015   1 RLTRAAIIIQAAWRGYLARKRYK 23
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
111-129 1.82e-04

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 38.45  E-value: 1.82e-04
                          10
                  ....*....|....*....
gi 1063684659 111 AAVTVQAAYRGYLARRAFK 129
Cdd:pfam00612   3 AAIKIQAAWRGYLARKRYK 21
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
111-133 5.37e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 37.52  E-value: 5.37e-04
                          10        20
                  ....*....|....*....|...
gi 1063684659 111 AAVTVQAAYRGYLARRAFKILKG 133
Cdd:cd23767    11 AATLIQALWRGYKVRKELKKKKK 33
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
321-446 3.49e-03

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 40.54  E-value: 3.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684659  321 QSVEPLPSMDNPQVDLEKVKRGLRKVHNPVVENSiqpQLVPQIAVEKPNGSLEESVNAFDEEKEDEVAETVVQQPEELIQ 400
Cdd:PTZ00341  1009 ENVEENIEENVEEYDEENVEEVEENVEEYDEENV---EEIEENAEENVEENIEENIEEYDEENVEEIEENIEENIEENVE 1085
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1063684659  401 THTPLGTNESLDSTLVNQIEESEENVMAEEKEDVKE--ERTPKQNHKE 446
Cdd:PTZ00341  1086 ENVEENVEEIEENVEENVEENAEENAEENAEENAEEydDENPEEHNEE 1133
 
Name Accession Description Interval E-value
DUF4005 pfam13178
Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing ...
485-551 4.95e-11

Protein of unknown function (DUF4005); This is a C-terminal region of plant IQ-containing putative calmodulin-binding proteins.


Pssm-ID: 404128  Cd Length: 97  Bit Score: 59.56  E-value: 4.95e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063684659 485 IPSYMQATKSAKAKLRLQgsSSPRQLGTTE------KASRRYSLPSSGNSAKITSHSPKTRVSNSSGKSGNKT 551
Cdd:pfam13178  27 LPNYMAATESAKAKLRSQ--SAPRQRPSTPerdrsgSAAKRLSLPAPSPNGKGSSYGPRARQVQASYKHSLRS 97
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
107-129 1.47e-05

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 41.93  E-value: 1.47e-05
                           10        20
                   ....*....|....*....|...
gi 1063684659  107 QQEIAAVTVQAAYRGYLARRAFK 129
Cdd:smart00015   1 RLTRAAIIIQAAWRGYLARKRYK 23
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
111-129 1.82e-04

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 459869  Cd Length: 21  Bit Score: 38.45  E-value: 1.82e-04
                          10
                  ....*....|....*....
gi 1063684659 111 AAVTVQAAYRGYLARRAFK 129
Cdd:pfam00612   3 AAIKIQAAWRGYLARKRYK 21
IQCD cd23767
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ...
111-133 5.37e-04

IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.


Pssm-ID: 467745 [Multi-domain]  Cd Length: 37  Bit Score: 37.52  E-value: 5.37e-04
                          10        20
                  ....*....|....*....|...
gi 1063684659 111 AAVTVQAAYRGYLARRAFKILKG 133
Cdd:cd23767    11 AATLIQALWRGYKVRKELKKKKK 33
PTZ00341 PTZ00341
Ring-infected erythrocyte surface antigen; Provisional
321-446 3.49e-03

Ring-infected erythrocyte surface antigen; Provisional


Pssm-ID: 173534 [Multi-domain]  Cd Length: 1136  Bit Score: 40.54  E-value: 3.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684659  321 QSVEPLPSMDNPQVDLEKVKRGLRKVHNPVVENSiqpQLVPQIAVEKPNGSLEESVNAFDEEKEDEVAETVVQQPEELIQ 400
Cdd:PTZ00341  1009 ENVEENIEENVEEYDEENVEEVEENVEEYDEENV---EEIEENAEENVEENIEENIEEYDEENVEEIEENIEENIEENVE 1085
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1063684659  401 THTPLGTNESLDSTLVNQIEESEENVMAEEKEDVKE--ERTPKQNHKE 446
Cdd:PTZ00341  1086 ENVEENVEEIEENVEENVEENAEENAEENAEENAEEydDENPEEHNEE 1133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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