|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
1-378 |
3.73e-140 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 406.19 E-value: 3.73e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 1 MGSALETLCGQAYGAGQIRMMGIYMQRSWVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAAN 80
Cdd:cd13132 59 LASALDTLCGQAFGAKNYKLVGVYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALF 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 81 FPIQKFLQSQRKVLVMAWISGVVLVIHAVFSWLFILYFKWGLVGAAITLNTSWWLIVIGQLLYILITKSDGA-WTGFSML 159
Cdd:cd13132 139 EPLKRYLQAQGIVLPLVYISLVALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKAtWGGFSRE 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 160 AFRDLYGFVKLSLASALMLCLEFWYLMVLVVVTGLLPnPLIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNA 239
Cdd:cd13132 219 AFRGWGPFLKLAIPSALMLCLEWWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNP 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 240 ALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVA 319
Cdd:cd13132 298 KRAKLAAIVALILSLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGA 377
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1063693918 320 YVNIACYYIIGLPAGLVLGFTLDLGVQGIWGGMVAGICLQTLILIGIIYFTNWNKEAEQ 378
Cdd:cd13132 378 YVNLVAYYLIGLPVGLLLAFVLGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
1-281 |
6.36e-40 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 144.70 E-value: 6.36e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 1 MGSALETLCGQAYGAGQIRMMGIYMQRSWVILFTTALFLLPV-YIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAA 79
Cdd:TIGR00797 48 LGTATTALVAQAVGAGNYQRLGRQAQQSLLLALLLGLPVLLVgYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 80 NFPIQKFLQSQRKVLVMAWISGVVLVIHAVFSWLFIL--YFKWGLVGAAITLNTSWWLIVIGQLLYILITKSDG-AWTGF 156
Cdd:TIGR00797 128 NFVLRGFLRGQGDTKTPMYITLIGNVINIILNYILIFgkFGFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGlKWEGL 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 157 SMLAFRDLYGFVKLSLASALMLCLEFWYLMVLVVVTGLLPNplIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGA 236
Cdd:TIGR00797 208 LKPDWEVLKRLLKLGLPIAFRVILESLSFALLALLVARLGS--IALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGA 285
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1063693918 237 GNAALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAV 281
Cdd:TIGR00797 286 GDPKRAKEVARVALKLSLLLGLVLAIILILFREFIARLFTNDPEV 330
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
1-364 |
2.73e-38 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 142.59 E-value: 2.73e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 1 MGSALETLCGQAYGAGQIRMMGIYMQRS-WVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAA 79
Cdd:COG0534 63 LGVGGTALVAQALGAGDREEARRVLGQAlLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLL 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 80 NFPIQKFLQSQRKVLVMAWISGVVLVIHAVFSWLFILYFKWGLVGAAITLNTSWWLIVIGQLLYILITKSDGAWTGFSM- 158
Cdd:COG0534 143 FNVLNGILRGLGDTKTPMIIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLr 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 159 LAFRDLYGFVKLSLASALMLCLEFWYLMVLVVVTGLLPNplIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGN 238
Cdd:COG0534 223 PDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGT--AAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGD 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 239 AALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALV 318
Cdd:COG0534 301 YDRARRAARLALLLALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFP 380
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1063693918 319 AYVNIACYYIIGLPAGLVLGFtLDLGVQGIWGGMVAGICLQTLILI 364
Cdd:COG0534 381 MIISLLRLWLVRLPLAYLLAF-LGLGLTGVWLALPIGEVLRALLLL 425
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
174-332 |
1.34e-17 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 79.15 E-value: 1.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 174 SALMLCLEFWYLMVLVVVTGLLPnpLIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITS 253
Cdd:pfam01554 2 IALENLLQSLYSLIDTLFVGHLG--AVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063693918 254 TLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACyYIIGLP 332
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIP 157
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
4-356 |
2.86e-17 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 82.94 E-value: 2.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 4 ALETLCGQAYGAGQIRMMG-IYMQRSWVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKF---ALWMIPQLFAYAA 79
Cdd:PRK01766 70 ALTPIVAQLNGAGRRERIAhQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYlhaLLWGIPAYLLYQV 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 80 nfpIQKFLQSQRKVLVMAWISGVVLVIHAVFSWLFIlYFKWGL-----VGAAITLNTSWWLIVIGQLLYILITKSD---G 151
Cdd:PRK01766 150 ---LRSFIDGLGKTKPTMVIGFLGLLINIPLNYIFI-YGKFGFpelggVGCGVATAIVYWVMFLAMLIYIKRARRFrdfR 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 152 AWTGFSMLAFRDLYGFVKLSLASALMLCLEfwylMVLVVVTGLLPNPL--IPVDAISICMNIEGWTAMISIGFNAAISVR 229
Cdd:PRK01766 226 LFKGLYKPDWAVIKRLLKLGLPIGLAIFFE----VSLFAVVTLLVSPLgtVTVAAHQIALNFSSLLFMLPLSLAMALTIR 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 230 VSNELGAGNAALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVA 309
Cdd:PRK01766 302 VGFELGAGRTLDARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGAL 381
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1063693918 310 VGAGWQALVAYVNIACYYIIGLPAGLVLGFTLDLGVQGIWGGMVAGI 356
Cdd:PRK01766 382 RGYKDTRVIFFITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGL 428
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
1-378 |
3.73e-140 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 406.19 E-value: 3.73e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 1 MGSALETLCGQAYGAGQIRMMGIYMQRSWVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAAN 80
Cdd:cd13132 59 LASALDTLCGQAFGAKNYKLVGVYLQRALVILLLCCVPISLLWLNTEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALF 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 81 FPIQKFLQSQRKVLVMAWISGVVLVIHAVFSWLFILYFKWGLVGAAITLNTSWWLIVIGQLLYILITKSDGA-WTGFSML 159
Cdd:cd13132 139 EPLKRYLQAQGIVLPLVYISLVALLLNILLNYLLVFVLGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKAtWGGFSRE 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 160 AFRDLYGFVKLSLASALMLCLEFWYLMVLVVVTGLLPnPLIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNA 239
Cdd:cd13132 219 AFRGWGPFLKLAIPSALMLCLEWWAFEILVLLAGLLP-GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNP 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 240 ALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVA 319
Cdd:cd13132 298 KRAKLAAIVALILSLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGA 377
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1063693918 320 YVNIACYYIIGLPAGLVLGFTLDLGVQGIWGGMVAGICLQTLILIGIIYFTNWNKEAEQ 378
Cdd:cd13132 378 YVNLVAYYLIGLPVGLLLAFVLGLGLKGLWIGLIAGLILQAVILLLIILRTDWDKEAEK 436
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
1-281 |
6.36e-40 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 144.70 E-value: 6.36e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 1 MGSALETLCGQAYGAGQIRMMGIYMQRSWVILFTTALFLLPV-YIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAA 79
Cdd:TIGR00797 48 LGTATTALVAQAVGAGNYQRLGRQAQQSLLLALLLGLPVLLVgYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 80 NFPIQKFLQSQRKVLVMAWISGVVLVIHAVFSWLFIL--YFKWGLVGAAITLNTSWWLIVIGQLLYILITKSDG-AWTGF 156
Cdd:TIGR00797 128 NFVLRGFLRGQGDTKTPMYITLIGNVINIILNYILIFgkFGFLGIVGAALATVISYWLMFLLLLYYIKKAKKIGlKWEGL 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 157 SMLAFRDLYGFVKLSLASALMLCLEFWYLMVLVVVTGLLPNplIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGA 236
Cdd:TIGR00797 208 LKPDWEVLKRLLKLGLPIAFRVILESLSFALLALLVARLGS--IALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGA 285
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1063693918 237 GNAALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAV 281
Cdd:TIGR00797 286 GDPKRAKEVARVALKLSLLLGLVLAIILILFREFIARLFTNDPEV 330
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
1-364 |
2.73e-38 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 142.59 E-value: 2.73e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 1 MGSALETLCGQAYGAGQIRMMGIYMQRS-WVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAA 79
Cdd:COG0534 63 LGVGGTALVAQALGAGDREEARRVLGQAlLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLL 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 80 NFPIQKFLQSQRKVLVMAWISGVVLVIHAVFSWLFILYFKWGLVGAAITLNTSWWLIVIGQLLYILITKSDGAWTGFSM- 158
Cdd:COG0534 143 FNVLNGILRGLGDTKTPMIIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLr 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 159 LAFRDLYGFVKLSLASALMLCLEFWYLMVLVVVTGLLPNplIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGN 238
Cdd:COG0534 223 PDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARLGT--AAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGD 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 239 AALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALV 318
Cdd:COG0534 301 YDRARRAARLALLLALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFP 380
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1063693918 319 AYVNIACYYIIGLPAGLVLGFtLDLGVQGIWGGMVAGICLQTLILI 364
Cdd:COG0534 381 MIISLLRLWLVRLPLAYLLAF-LGLGLTGVWLALPIGEVLRALLLL 425
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
3-356 |
2.52e-31 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 123.38 E-value: 2.52e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 3 SALETLCGQAYGAGQIRMMGIYMQRSWVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFP 82
Cdd:cd13131 60 LAVTPLVAQAHGAGDRRRIRRAVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQV 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 83 IQKFLQSQRKVLVMAWISGVVLVIHAVFSWLFIlYFKWGL-----VGAAITLNTSWWLIVIGQLLYIL---ITKSDGAWT 154
Cdd:cd13131 140 LRSFLDALGRTRPAMVITLLALVLNIPLNYVLI-FGKFGLpalggAGAGLATAIVYWLMFLALAFYIRrhkRFRRYRLFA 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 155 GFSMLAFRDLYGFVKLSLASALMLCLEfwylMVLVVVTGLLPNPL--IPVDAISICMNIEGWTAMISIGFNAAISVRVSN 232
Cdd:cd13131 219 RFWRPDWARLKELLRLGLPIGLTIFFE----VSLFAAVALLMGRLgtTVLAAHQIALNFASLLFMVPLGISMAATVRVGF 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 233 ELGAGNAALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGA 312
Cdd:cd13131 295 ALGAGDPADARRAGLVGLGLGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGY 374
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1063693918 313 GWQALVAYVNIACYYIIGLPAGLVLGFTLDLGVQGIWGGMVAGI 356
Cdd:cd13131 375 KDTRVPFLLALISYWGIGLPLGYLLAFTTGLGAFGVWIGLIIGL 418
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
11-372 |
7.16e-28 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 113.76 E-value: 7.16e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 11 QAYGAGQIRMMGIYMQRSWVILFTTALFLLPV-YIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQS 89
Cdd:cd13137 66 QSYGAGDYERARRALGQSLLLALLLSLPLALLgLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRG 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 90 QRKVLVMAWISGVVLVIHAVFSWLFILY----FKWGLVGAAITLNTSWwLIVIGQLLYILITKSDGAWTGFSMLAFR--D 163
Cdd:cd13137 146 AGDTKTPMYIMIIVNVLNIVLDYVLIFGlwgfPGLGVAGAALATVISR-VVGALLLLFLLLRGRLPIKISFKGFRLDrkI 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 164 LYGFVKLSLASALMLCLEFWYLMVLVVVTGLLPNplIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAK 243
Cdd:cd13137 225 IKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGT--AALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEAR 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 244 FSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNI 323
Cdd:cd13137 303 RYGKRALRLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINL 382
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1063693918 324 ACYYIIGLPAGLVLGFTLDLGVQGIWGGMVAGICLQTLILIGIIYFTNW 372
Cdd:cd13137 383 ISMWLVRLPLAYLLGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKW 431
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
1-373 |
5.02e-19 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 88.29 E-value: 5.02e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 1 MGSALETLCGQAYGAGQIRMMGIYMQRSWVILFTTALFLLPV-YIWAPPILSFFG---EAPHISKAAGKFALWMIPQLFA 76
Cdd:cd13138 59 LSMGGTILISQYIGAKDEEKAKKAVGTLLVLFLILGIVLTILgLLFAPPILRLMNtpaEILELAVSYLRICFLGIPFIFG 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 77 YAAnfpIQKFLQSQRKVLVMAWISGVVLVIHAVFSWLFILYFKWGLVGAAITLNTSWWLIVIGQLLYILITKSDGAWTGF 156
Cdd:cd13138 139 YNA---YSAILRGLGDSKTPLYFVIIACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPFKLSLK 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 157 SMLAFRDLYG-FVKLSLASALMLCLE---FWYLMVLVVVTGLlpnplIPVDAISICMNIEGWTAMISIGFNAAISVRVSN 232
Cdd:cd13138 216 DFRFDKEILKeILKIGLPSALQQSLVsisFLIINSIVNSYGV-----VASAAYGIANKINSFAFLPPSAIGQAVSTFVAQ 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 233 ELGAGNAALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGA 312
Cdd:cd13138 291 NIGAGKIERAKKGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGL 370
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063693918 313 GWQALVAYVNIACYYIIGLPAGLVLGFTLDLGVQGIWGGMVAGICLQTLILIGIIYFTNWN 373
Cdd:cd13138 371 GKTKFPMIISILRLWLVRIPLAYLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
2-368 |
1.10e-18 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 86.99 E-value: 1.10e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 2 GSALETLCGQAYGAGQIRMMGIYMQRS-WVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAAN 80
Cdd:cd12082 51 SVGTSALISQAIGAGDEEKARRVLVQSiVLAILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLG 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 81 FPIQKFLQSQRKVLVMAWISGVVLVIHAVFSWLFILYF---KWGLVGAAITLNTSWWLIVIGQLLYILITKSDGAWTGFS 157
Cdd:cd12082 131 AVLSGILQGEGDTRTAMIISVLSNLLNILLDPLLIFGLgppELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSL 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 158 MLAFRDLYG-FVKLSLASALMLCLEFWYLMVLVVVTGLLPNPLIpVDAISICMNIEGWTAMISIGFNAAISVRVSNELGA 236
Cdd:cd12082 211 LKPDLELLRrLLRIGLPSAIQNSLLSLGLLIIVAIVAAFGGAAA-LAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGA 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 237 GNAALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQA 316
Cdd:cd12082 290 GNFDRARRITWVALLIGLLIGAVLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTL 369
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1063693918 317 LVAYVNIACYYIIGLPAGLVLGFtLDLGVQGIWGGMVAGICLQTLILIGIIY 368
Cdd:cd12082 370 KSLIVSLLSYWVVRLPLAYVLAY-LGLGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-372 |
2.05e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 86.43 E-value: 2.05e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 7 TLCGQAYGAGQIRMMGIYMQRSWVILFTTALFLLPVYIWAPP-ILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQK 85
Cdd:cd13133 66 VFVAQYNGAGRYSRIGRVLWQGLYFSLLLAPLLALLSALAAPlLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRA 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 86 FLQSQRKVLVMAWISGVVLVIHAVFSWLFIL----YFKWGLVGAAITLNTSWWLIVIGQLLYILITKSD-----GAWTGF 156
Cdd:cd13133 146 FFSGIGRTRVVMVANLVMVVVNIVLDYALIFgklgFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRrrfglRRAWRF 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 157 SMLAFRDLygfVKLSLASALMLCLEFWYLMVLVVVTGLLpnPLIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGA 236
Cdd:cd13133 226 DRELLRRI---LRLGLPSGLQFFLDVGAFTVFFLLIGRL--GTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGA 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 237 GNAALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFT---SSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAG 313
Cdd:cd13133 301 GRPDLAMRVTRRGLKLALAYMLLLGILFLLFPELLLSIFTpgaDFALIAELAVPLLRFVAAYILFDALALVFAGALRGAG 380
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1063693918 314 WQALVAYVNIACYYIIGLPAGLVLGfTLDLGVQGIWGGMVAGICLQTLILIGIIYFTNW 372
Cdd:cd13133 381 DTRFVMLAELIVAWLYLLPPAYLLV-VLGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
174-332 |
1.34e-17 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 79.15 E-value: 1.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 174 SALMLCLEFWYLMVLVVVTGLLPnpLIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITS 253
Cdd:pfam01554 2 IALENLLQSLYSLIDTLFVGHLG--AVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILG 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063693918 254 TLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACyYIIGLP 332
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIP 157
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
4-356 |
2.86e-17 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 82.94 E-value: 2.86e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 4 ALETLCGQAYGAGQIRMMG-IYMQRSWVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKF---ALWMIPQLFAYAA 79
Cdd:PRK01766 70 ALTPIVAQLNGAGRRERIAhQVRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYlhaLLWGIPAYLLYQV 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 80 nfpIQKFLQSQRKVLVMAWISGVVLVIHAVFSWLFIlYFKWGL-----VGAAITLNTSWWLIVIGQLLYILITKSD---G 151
Cdd:PRK01766 150 ---LRSFIDGLGKTKPTMVIGFLGLLINIPLNYIFI-YGKFGFpelggVGCGVATAIVYWVMFLAMLIYIKRARRFrdfR 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 152 AWTGFSMLAFRDLYGFVKLSLASALMLCLEfwylMVLVVVTGLLPNPL--IPVDAISICMNIEGWTAMISIGFNAAISVR 229
Cdd:PRK01766 226 LFKGLYKPDWAVIKRLLKLGLPIGLAIFFE----VSLFAVVTLLVSPLgtVTVAAHQIALNFSSLLFMLPLSLAMALTIR 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 230 VSNELGAGNAALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVA 309
Cdd:PRK01766 302 VGFELGAGRTLDARQYAYIGLAVGLGMALLTAIFLVLFREQIALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGAL 381
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1063693918 310 VGAGWQALVAYVNIACYYIIGLPAGLVLGFTLDLGVQGIWGGMVAGI 356
Cdd:PRK01766 382 RGYKDTRVIFFITFIAYWVLGLPLGYILALTDPMGPFGFWIGLIIGL 428
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-364 |
1.82e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 77.54 E-value: 1.82e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 8 LCGQAYGAG------QIRMMGIYMqrswVILFTTALFLLpVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANF 81
Cdd:cd13134 65 LIAQYLGAKdkkkarQIAGVALLF----NLLLGLVFSLL-LLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 82 PIQKFLQSQRKVLVMAWISGVVLVIHAVFSWLFILYF----KWGLVGAAITLNTSWWLIVIGQLLYILITKSDGAWT-GF 156
Cdd:cd13134 140 TLSAILRSHGRTKIPMYVSLIMNILNIVGNYLLIFGWfglpKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLkDL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 157 SMLAFRDLYGFVKLSLASAL-MLCLEFWYLMVLVVVTGLLPNPLIpvdAISICMNIEGWTAMISIGFNAAISVRVSNELG 235
Cdd:cd13134 220 RPFPKKLLKKILKIGLPSAGeELSYNLSQTVITAFIARLGTAALA---ARTYASNISMFVFLFSLAIGQATQIIVGHLVG 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 236 AGNAALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQ 315
Cdd:cd13134 297 AGDFDEAYKRVLKSLKIGLLVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDA 376
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1063693918 316 ALVAYVNIACYYIIGLPAGLVLGFTLDLGVQGIWGGMVAGICLQTLILI 364
Cdd:cd13134 377 RFPVLIGIISMWGISVPLAYLLGIVLGLGLLGVWIAFAADEWVRGIIML 425
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
29-349 |
1.82e-15 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 77.55 E-value: 1.82e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 29 WVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGVVLVIHA 108
Cdd:cd13143 89 LLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGMLIGAVLNI 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 109 VFSWLFILYFKWGLVGAAITLNTSWwliVIGQLLYILITKSDGAWTGFSM----LAFRDLYGFVKLSLASALMlcleFWY 184
Cdd:cd13143 169 ILDPLFIFVLGLGIAGAALATVIAQ---LISLLLLLLYFFRGKSLLKLSLlrfkLSLKIIKEILALGFPSFLM----QLS 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 185 LMVLVVVTGLLPNPL---IPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLIGIVCM 261
Cdd:cd13143 242 SSVVTIVLNLTLLGYggdIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLF 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 262 IVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSG--VAVGAGWQALVayvnIACYYIIGLPAGLVLGF 339
Cdd:cd13143 322 LILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGyfQAIGKAKRAAL----LSLLRQGLFLIPLLLIL 397
|
330
....*....|
gi 1063693918 340 TLDLGVQGIW 349
Cdd:cd13143 398 PRLFGLDGIW 407
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
1-113 |
1.90e-15 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 73.37 E-value: 1.90e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 1 MGSALETLCGQAYGAGQIRMMGIYMQRSWVILFTTALFL-LPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAA 79
Cdd:pfam01554 48 LGTALTTLVGQALGAGNFKRAGVALRQGLILGLLLSLPIaLLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYAL 127
|
90 100 110
....*....|....*....|....*....|....
gi 1063693918 80 NFPIQKFLQSQRKVLVMAWISGVVLVIHAVFSWL 113
Cdd:pfam01554 128 QFVLSGFLRGQGDTKPPMYINIISLLLNIPLNYL 161
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
11-368 |
9.27e-14 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 72.21 E-value: 9.27e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 11 QAYGAGQ-IRMMGIYMQRSWVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQS 89
Cdd:cd13136 69 QALGAGDrEEAIALLVRALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRG 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 90 QRKVLVMAWISGVVLVIHAVFSWLFILYFKWGLVGAAITLNTSWWLIVIGQLLYILITKSDGAWTGFSML-AFRDLYGFV 168
Cdd:cd13136 149 LQDTRTPLILQIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLpSKAALKRLF 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 169 KLSLASAL-MLCLEFWYLMVLVVVTGLLPNPLIpvdAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVI 247
Cdd:cd13136 229 KLNRDIFIrTLALLAAFLFFTALAARLGDVILA---ANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVAR 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 248 VVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACyY 327
Cdd:cd13136 306 RLLQWGLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVS-L 384
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1063693918 328 IIGLPAGLVLGFTldLGVQGIWGGMVAGICLQTLILIGIIY 368
Cdd:cd13136 385 AVFLPLLFLLVPL--WGNHGLWLALILFMLLRGLTLALRLP 423
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
10-349 |
2.82e-13 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 70.63 E-value: 2.82e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 10 GQAYGAGQIRMMGIYMQRS-WVILFTTALFLLPVYIWAPPILSFFG-EAPHISKAAGKFALWMIPQLFAYAANFPIQKFL 87
Cdd:cd13140 69 SQSIGAKDEKEARKYARNAlQLNLLLGILYGLLLLLFAKPLIGFFNlGDAEVISLAITYLRIVALGLIFSFLNPVFTGIF 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 88 QSQRKVLVMAWISGVVLVIHAVFSWLFILYF----KWGLVGAAITLNTSWWLIVIGQLLYIL-ITKSDGAWTGFSMLAFR 162
Cdd:cd13140 149 NALGDSKTPFIINAIGLVLNIILDPLLIFGFgpfpALGVAGAALATVLAQAIVFLLFLYALKkKKGLFLKIRILKRPDRK 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 163 DLYGFVKLSLASALMLCL-EFWYLMVLVVVTGLLPnplIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAAL 241
Cdd:cd13140 229 YIKEILKLGLPVALQSILfALISMILARIIASFGP---VAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDR 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 242 AKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYV 321
Cdd:cd13140 306 IRKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAII 385
|
330 340
....*....|....*....|....*...
gi 1063693918 322 NIACYYiIGLPAGLVLGFTLdLGVQGIW 349
Cdd:cd13140 386 SIVFNG-LRIPLALLLSPTG-LGLNGIW 411
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
7-374 |
2.79e-11 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 64.52 E-value: 2.79e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 7 TLCGQAYGAGQIRMMGIYMQR--SWVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQ 84
Cdd:cd13142 72 ALVAQYTGAGDYDKANKVAGQtfSFVIILSLILAVLGYILSRPLLLLLIGAPEEVYPLALAYLRIIFLGLPFMFIFFVFN 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 85 KFLQSQRKVLVMAWISGVVLVIHAVFSWLFILYF----KWGLVGAAITLNTSWwLIVIGQLLYILITKSDGAWTGFSMLA 160
Cdd:cd13142 152 SLLRGIGDTKTPMKIMFGSVLLNVILDPLLIFGIgpfpGLGVAGAALATVISR-GIAAVIGLYLLFKGRVGLKISLRDLK 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 161 F-RDLYG-FVKLSLASALMLCLEFWYLMVLVVVTGLLPNPLipVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGN 238
Cdd:cd13142 231 PdWEWLKkIFRIGLPSSIEQSARALGFTVMTALVAGFGTVV--VAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQ 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 239 AALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALV 318
Cdd:cd13142 309 IDRAEEIVKKAALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTA 388
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1063693918 319 AYVNIACYYIIGLPAGLVLGFTLDLGVQGIWGGMVAGICLQTLILIGIIYFTNWNK 374
Cdd:cd13142 389 MIISILRLWVIRIPLAYLLAYVLGLGVTGIWIAMAISNIVAALIALAWFKRGTWKK 444
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
1-143 |
5.43e-08 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 54.38 E-value: 5.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 1 MGSALETLCGQAYGAGQIRMMGIYMQRS-WVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAA 79
Cdd:COG0534 284 LGQAAQPLVGQNLGAGDYDRARRAARLAlLLALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGL 363
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063693918 80 NFPIQKFLQSQRKVLVMAWISGVVLVIHAVFSWLFILYFKWGLVGAAITLNTSWWLIVIGQLLY 143
Cdd:COG0534 364 QFVLSGALRGAGDTRFPMIISLLRLWLVRLPLAYLLAFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-365 |
2.53e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 52.29 E-value: 2.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 8 LCGQAYGAGQIRMMGIYMQRSWV--ILFTTALFLLpVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQK 85
Cdd:cd13135 63 LGSQSVGAKDIKRINDYAISSIVynSIIGVILFLL-WLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSS 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 86 FLQ--SQRKVLVMAWISGVVLVIhaVFSWLFIL----YFKWGLVGAAITLNTSWWLIVIgqLLYILITKSDGAWTGFSM- 158
Cdd:cd13135 142 ILQgiGETKPIMYGGIIKNLLNV--ILDYVLIFgnfgFPRLGIIGAAIATTIANVLNLI--ILVYLCRKIKKLTFKLSNt 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 159 ----LAFRDLYGFVKLSLASALMLCLefWYLMVLVVVTGLLPNPLIPVDAISICMNIEGWTAMISIGFNAAISVRVSNEL 234
Cdd:cd13135 218 kvlkANIRPYKFTIKLGLPLGGEEFL--WNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESI 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 235 GAGNAALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGW 314
Cdd:cd13135 296 GKKDLKEALRIGNICLGLGLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGD 375
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 1063693918 315 QALVAYVNIACYYIIGLPAgLVLGFTLDLGVQGIWGGMVAGICLQTLILIG 365
Cdd:cd13135 376 TKWMLYTQIIGTIIVVSVA-LLLIFVFKLGLAGVYITLFIDEIIRAIINFL 425
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
23-369 |
2.52e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 46.07 E-value: 2.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 23 IYMQRSWVILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQS------QRKVLVM 96
Cdd:cd13139 92 AAVQAILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGagdaaiAMRSLWL 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 97 AWISGVVLVIHAVFSWLFILyfKWGLVGAAITLNTSWWLIVIGQLlYILITKSDGAWTGFSMLAFR----------DLYG 166
Cdd:cd13139 172 ANGLNIILDPLFIFGLGPIP--AMGVTGAAIATTIGRSIGVLYQL-YHLFKGKGRIQIRRRHLKLDwaiikkiikiAVGG 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 167 FVKLSLASALMLclefwYLMVLVVVTGLlpnplIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSV 246
Cdd:cd13139 249 ILQFLIASSSWI-----FLVRIIAEFGS-----TALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSV 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 247 -IVVSITSTLIGIVCmIVVLATKDSFPYLFTSSEAV---AAETTRIaVLLGFTVLLNSLqpVLSGVAVGAGWQALVAYVN 322
Cdd:cd13139 319 wRAGKYNMVFLGIVS-LVFFLFAEPLVSFFTTDPEViaiAVEALRI-ISLGYIFYGYGM--VLSQAFNGAGDTKTPTLIN 394
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1063693918 323 IACYYIIGLPAGLVLGFTLDLGVQGIWGGMVagICLQTLILIGIIYF 369
Cdd:cd13139 395 LVGFWLFQIPLAYLLARHLNLGPKGVFIAIP--IAETVLAIAAIILF 439
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
217-356 |
6.21e-05 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 44.74 E-value: 6.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 217 MISIGFNAAISVRVSNELGAGNAALAKFSVIV-VSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAV-LLGF 294
Cdd:PRK00187 286 MVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVgIGFGAVVMLLFAGLFWLLPEAIIGLFLDRNDPAFAEIVQLAVsLLAV 365
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063693918 295 TV---LLNSLQPVLSGVAVGAGWQALVAYVNIACYYIIGLPAGLVLGFTLDLGVQGIWGGMVAGI 356
Cdd:PRK00187 366 AAwfeLFDGTQTIAMGAIRGLKDARTTFLIGLACYWLVGAPLAWLLAFTLGWGAVGVWWGLALGL 430
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
204-369 |
1.34e-04 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 43.59 E-value: 1.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 204 AISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAA 283
Cdd:COG0534 45 AVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 284 ETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACyYIIGLPAGLVLGFTLDLGVQGIWGGMVAGICLQTLIL 363
Cdd:COG0534 125 LARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIG-NVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLL 203
|
....*.
gi 1063693918 364 IGIIYF 369
Cdd:COG0534 204 LYYLFR 209
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
1-145 |
2.83e-04 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 42.70 E-value: 2.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 1 MGSALETLCGQAYGAGQIRMMGIYMQRSWVILFTTALFL-LPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAA 79
Cdd:cd12082 275 LAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLgLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGI 354
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063693918 80 NFPIQKFLQSQRKVLVMAWISGVVLVIHAVFSWLFILYFKWGLVGAAITLNTSWWLIVIGQLLYIL 145
Cdd:cd12082 355 GYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLGLGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
217-369 |
4.80e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 42.10 E-value: 4.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 217 MISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTV 296
Cdd:cd13134 53 LIFSFISTGTSILIAQYLGAKDKKKARQIAGVALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSL 132
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063693918 297 LLNSLQPVLSGVAVGAGWQALVAYVNIACYYI-IGLPAGLVLGF--TLDLGVQGIWGGMVAGICLQTLILIGIIYF 369
Cdd:cd13134 133 FLQALSLTLSAILRSHGRTKIPMYVSLIMNILnIVGNYLLIFGWfgLPKLGVAGVAISTVISRAVGLVLLFILLFR 208
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
204-374 |
9.04e-04 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 41.16 E-value: 9.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 204 AISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLIGIVCMIVVLATKDSFPYLFTSSEAVAA 283
Cdd:cd12082 32 AVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLAILLGLLLAALLLFFSPLILSLLGAEEEVIE 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 284 ETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACyYIIGLPAGLVLGFTLDLGVQGIWGGMVAGICLQTLIL 363
Cdd:cd12082 112 LAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLS-NLLNILLDPLLIFGLGPPELGIAGAALATVISYVIGA 190
|
170
....*....|.
gi 1063693918 364 IGIIYFTNWNK 374
Cdd:cd12082 191 LLLLIYLRKGK 201
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
32-355 |
5.52e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 38.54 E-value: 5.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 32 LFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGVVLVIHAVFS 111
Cdd:cd13146 98 LLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMAMLIGTVVNIVLD 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 112 WLFILYFKWGLVGAAITLNTSWWLIVIGQLLYILITKSDGAWT-GFSMLAFRDLYGFVKLSLASALM-LCLEFWYLMVLV 189
Cdd:cd13146 178 PILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIGKSNVTIHiKLSNISSSVIVEILRVGLPQMLLqLISSISFLIYNR 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 190 VVTGLLPNPLipvDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITSTLI-GIVCMIVVLATK 268
Cdd:cd13146 258 IIIDIDPVAM---TAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVvLVLVLGYVLVAP 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 269 DSFPYLFTSSEAV--AAETTRIaVLLGFTVLLNSLQPVLSGVAVGAGWQALVayVNIACYYIIGLPAGLVLGFTLDLGVQ 346
Cdd:cd13146 335 WLFSLFTTVPEVVayAVLQVRT-MALALPFVAISILVTEFFQAIGKAWPSLL--LTLIRHVFLSVPVVYLLAYVFGKGIT 411
|
....*....
gi 1063693918 347 GIWGGMVAG 355
Cdd:cd13146 412 GVYFGIVSA 420
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
1-145 |
5.96e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 38.73 E-value: 5.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 1 MGSALETLCGQAYGAGQI-RMMGIYMqRSWVILFTTALFL-LPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYA 78
Cdd:cd13145 289 LNTAVLSIAGQNFGAKKYdRVRETYK-KALKYGFVIMVVAtVFLLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAYV 367
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063693918 79 ANFPIQKFLQSQRKVLVMAWISGV-VLVIHAVFSWLFILYFKWGLVGAAITLNTSWWLIVIGQLLYIL 145
Cdd:cd13145 368 VLFISVSVLQGLKRPIFALWIGLYrQLVGPALVFWLLVNVLGLGVTGIWWGIFTIVWSAAIIALLYTR 435
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
30-349 |
6.44e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 38.37 E-value: 6.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 30 VILFTTALFLLPVYIWAPPILSFFGEAPHISKAAGKFALWMIPQLFAYAANFPIQKFLQSQRKVLVMAWISGVVLVIHAV 109
Cdd:cd13144 93 LALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLIGAIINII 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 110 FSWLFILYF----KWGLVGAAITlntswwlIVIGQ------LLYILITKS-----DGAWTGFSMLAFRDLYgfvKLSLAS 174
Cdd:cd13144 173 LDPILIFGLfgfpAMGIAGAAIA-------TVIGQilamflAFFFLLRKNkdvqpDLRLFRPSLRIIKEIY---AVGLPS 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 175 ALMLCLEfwYLMVLVVVTGLLPNPLIPVDAISICMNIEGWTAMISIGFNAAISVRVSNELGAGNAALAKFSVIVVSITST 254
Cdd:cd13144 243 IIMQAIS--SVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAV 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693918 255 LIGIVCMIVVLATKDSFPYLFTSSEAVAAETTRIAVLLGFTVLLNSLQPVLSGVAVGAGWQALVAYVNIACYYIIGLPAG 334
Cdd:cd13144 321 VIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLPLA 400
|
330
....*....|....*
gi 1063693918 335 LVLGFTldLGVQGIW 349
Cdd:cd13144 401 WLLAKM--FGLNGVW 413
|
|
| |
