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Conserved domains on  [gi|1063694312|ref|NP_001322509|]
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SNARE-like superfamily protein [Arabidopsis thaliana]

Protein Classification

trafficking protein particle complex subunit 1 TRAPPC1/BET5( domain architecture ID 13000937)

trafficking protein particle complex subunit 1, also called BET5 homolog, or multiple myeloma protein 2 (MUM-2), may play a role in vesicular transport from endoplasmic reticulum to Golgi.

CATH:  3.30.450.70
Gene Ontology:  GO:0016192|GO:0030008
PubMed:  17110339|18585354

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRAPPC1_MUM2 cd14855
Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 ...
 24-164 4.52e-67

Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 (TRAPPC1), also known as MUM2 and BET5, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


:

Pssm-ID: 341445  Cd Length: 132  Bit Score: 200.47  E-value: 4.52e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694312  24 HMMYVFNRNGVCLLYKEWNRP---LHTLNPQQDHKLMFGLLFSLKSLTAKMDPVNADkgnlgvpqlpgqgCSFHSFRTNT 100
Cdd:cd14855     1 YSFYIFDRHGNCIYYREWNRPkqsSNGKSEEEEQKLMFGLLFSLKSFVRKISPTDDT-------------CGFHSYTTNK 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063694312 101 YKLSFMETPSGIKIILVTHPKTGDLRESLKYIYS-LYVEYVVKNPIYSPGSPIKSELFNTALDQY 164
Cdd:cd14855    68 YKLHYYETPTGLKFVLLTDPNVGDLRDVLQQIYSnIYVEYVVKNPLYPPGEPITSELFRSKLDQY 132
 
Name Accession Description Interval E-value
TRAPPC1_MUM2 cd14855
Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 ...
 24-164 4.52e-67

Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 (TRAPPC1), also known as MUM2 and BET5, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341445  Cd Length: 132  Bit Score: 200.47  E-value: 4.52e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694312  24 HMMYVFNRNGVCLLYKEWNRP---LHTLNPQQDHKLMFGLLFSLKSLTAKMDPVNADkgnlgvpqlpgqgCSFHSFRTNT 100
Cdd:cd14855     1 YSFYIFDRHGNCIYYREWNRPkqsSNGKSEEEEQKLMFGLLFSLKSFVRKISPTDDT-------------CGFHSYTTNK 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063694312 101 YKLSFMETPSGIKIILVTHPKTGDLRESLKYIYS-LYVEYVVKNPIYSPGSPIKSELFNTALDQY 164
Cdd:cd14855    68 YKLHYYETPTGLKFVLLTDPNVGDLRDVLQQIYSnIYVEYVVKNPLYPPGEPITSELFRSKLDQY 132
Sybindin pfam04099
Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the ...
 23-168 3.88e-66

Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses.


Pssm-ID: 282019  Cd Length: 134  Bit Score: 197.92  E-value: 3.88e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694312  23 AHMMYVFNRNGVCLLYKEWNRPLHTLNPQQDHKLMFGLLFSLKSLTAKMDPvnadkgnlgvpqLPGQgCSFHSFRTNTYK 102
Cdd:pfam04099   1 IFSLYIFNRAGGLIYYKEWNRPKKTKLTTNEYKLLAGMLHSLHSISSKISP------------LPGS-SGIESLETDTFK 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063694312 103 LSFMETPSGIKIILVTHPKTGDLRESLKYIYS-LYVEYVVKNPIYSPGSPIKSELFNTALDQYVRSI 168
Cdd:pfam04099  68 LHCLETLTGIKFVLVTDPGTGINRDSLLRKYYeLYSDYVLKNPFYSLGMPIRCELFDEKLDQYVRSL 134
TRS23 COG5122
Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];
24-167 6.41e-13

Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];


Pssm-ID: 227451  Cd Length: 134  Bit Score: 62.22  E-value: 6.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694312  24 HMMYVFNRNGVCLLYKEWNRPLHTLNPQQdHKLMFGLLFSLKSLTAKMDPVnadKGNLGVPQLPGQGCSFHSFRTNTykl 103
Cdd:COG5122     4 EQFFIINKSGGLIFQREFGEGETELNSNE-YLILASTLHGVSAILTQTIPL---PGSSGRLVLYFRNFVMTIFQTTT--- 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063694312 104 sfmetpsGIKIILVTHPKTGDLRESLKYIYSLYVEYVVKNPIYSPGSPIKSELFNTALDQYVRS 167
Cdd:COG5122    77 -------GTKFVFVAEKRTVNALFQLQKIYSLYSDYVTKNPFYSPEMPIQCSLFDEHLKRMFEG 133
 
Name Accession Description Interval E-value
TRAPPC1_MUM2 cd14855
Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 ...
 24-164 4.52e-67

Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 (TRAPPC1), also known as MUM2 and BET5, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341445  Cd Length: 132  Bit Score: 200.47  E-value: 4.52e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694312  24 HMMYVFNRNGVCLLYKEWNRP---LHTLNPQQDHKLMFGLLFSLKSLTAKMDPVNADkgnlgvpqlpgqgCSFHSFRTNT 100
Cdd:cd14855     1 YSFYIFDRHGNCIYYREWNRPkqsSNGKSEEEEQKLMFGLLFSLKSFVRKISPTDDT-------------CGFHSYTTNK 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063694312 101 YKLSFMETPSGIKIILVTHPKTGDLRESLKYIYS-LYVEYVVKNPIYSPGSPIKSELFNTALDQY 164
Cdd:cd14855    68 YKLHYYETPTGLKFVLLTDPNVGDLRDVLQQIYSnIYVEYVVKNPLYPPGEPITSELFRSKLDQY 132
Sybindin pfam04099
Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the ...
 23-168 3.88e-66

Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses.


Pssm-ID: 282019  Cd Length: 134  Bit Score: 197.92  E-value: 3.88e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694312  23 AHMMYVFNRNGVCLLYKEWNRPLHTLNPQQDHKLMFGLLFSLKSLTAKMDPvnadkgnlgvpqLPGQgCSFHSFRTNTYK 102
Cdd:pfam04099   1 IFSLYIFNRAGGLIYYKEWNRPKKTKLTTNEYKLLAGMLHSLHSISSKISP------------LPGS-SGIESLETDTFK 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063694312 103 LSFMETPSGIKIILVTHPKTGDLRESLKYIYS-LYVEYVVKNPIYSPGSPIKSELFNTALDQYVRSI 168
Cdd:pfam04099  68 LHCLETLTGIKFVLVTDPGTGINRDSLLRKYYeLYSDYVLKNPFYSLGMPIRCELFDEKLDQYVRSL 134
TRAPPC4_synbindin cd14856
Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 ...
 27-164 1.04e-25

Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin or TRS23, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341446  Cd Length: 127  Bit Score: 94.89  E-value: 1.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694312  27 YVFNRNGvCLLY-KEWNRPLHTLNPQQdhKLMF-GLLFSLKSLTAKMDPVNADKGnlgvpqlpgqgcsFHSFRTNTYKLS 104
Cdd:cd14856     4 YIINKAG-GLIYqKDFSDALAKLSSND--YLRLaSTFHGLHAIAAQLSPVPGSSG-------------IELLETDTFRLH 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694312 105 FMETPSGIKIILVTHPKTGDLRESLKYIYSLYVEYVVKNPIYSPGSPIKSELFNTALDQY 164
Cdd:cd14856    68 CFQTLTGIKFVLVADPKQPGLDALLRRVYELYADYVLKNPFYELEMPIRCELFDENLQKL 127
TRAPPC_longin-like cd14853
Longin-like domains of Trafficking protein particle complex; Longin-like domains of a ...
 24-164 2.83e-22

Longin-like domains of Trafficking protein particle complex; Longin-like domains of a subfamily of core components of the trafficking protein particle complex (TRAPP), including TRAPPC2, TRAPPC4, TRAPPC1 and a TRAPPC2L, whose function is not known. TRAPP complexes are required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341443  Cd Length: 132  Bit Score: 86.38  E-value: 2.83e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694312  24 HMMYVFNRNGVCLLYKEWNRPLHTLNP-QQDHKLMFGLLFSLKSLTAKMDPVNADKGnlgvpqlpgqgcsFHSFRTNTYK 102
Cdd:cd14853     1 FYFVVVGHHGNPLYEREFTPPGQAEDDnEEEYKLLAGMLHSVRSINSKLSPNVEKYL-------------KLSDKTNEYK 67

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063694312 103 LSFMETPSGIKIILVTHPKTGDLRESLKYIYS-LYVEYVVKNPIYS--PGSPIKSELFNTALDQY 164
Cdd:cd14853    68 VHAYVTATGLKFVMLTDVLMDRIEDVLKNFFSdLYVLYVKKNPNPFyePNSPIRSRLFDSKVQSL 132
TRS23 COG5122
Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];
24-167 6.41e-13

Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];


Pssm-ID: 227451  Cd Length: 134  Bit Score: 62.22  E-value: 6.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694312  24 HMMYVFNRNGVCLLYKEWNRPLHTLNPQQdHKLMFGLLFSLKSLTAKMDPVnadKGNLGVPQLPGQGCSFHSFRTNTykl 103
Cdd:COG5122     4 EQFFIINKSGGLIFQREFGEGETELNSNE-YLILASTLHGVSAILTQTIPL---PGSSGRLVLYFRNFVMTIFQTTT--- 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063694312 104 sfmetpsGIKIILVTHPKTGDLRESLKYIYSLYVEYVVKNPIYSPGSPIKSELFNTALDQYVRS 167
Cdd:COG5122    77 -------GTKFVFVAEKRTVNALFQLQKIYSLYSDYVTKNPFYSPEMPIQCSLFDEHLKRMFEG 133
Sedlin_N pfam04628
Sedlin, N-terminal conserved region; Mutations in this protein are associated with the ...
 97-167 4.40e-08

Sedlin, N-terminal conserved region; Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400). This family represents an N-terminal conserved region.


Pssm-ID: 335859  Cd Length: 129  Bit Score: 49.18  E-value: 4.40e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063694312  97 RTNTYKLSFMETPSGIKIILV---THPKTGDLRESLKYIYSLYVEYVVkNPIYSPGSPIKSELFNTALDQYVRS 167
Cdd:pfam04628  57 KFYKLSVSAYVTNSHIKFILVhesSTKSDENIKQFFQEVHELYVKTLM-NPFYKPNDPIRSPAFDKKVRKLAKK 129
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 108-162 5.32e-07

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341444  Cd Length: 135  Bit Score: 46.43  E-value: 5.32e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694312 108 TPSGIKIILV-----THPKTGDLRESLKYIYSLYVEYVVkNPIYSPGSPIKSELFNTALD 162
Cdd:cd14854    73 TNTKVKFILVledtnTPLRDNDVRTLFRRLHNAYVDAVS-NPFYPPGTPITSKKFDRRVD 131
longin-like cd14818
Longin-like domains; Longin-like domains are small protein domains present in a variety of ...
 24-164 8.84e-07

Longin-like domains; Longin-like domains are small protein domains present in a variety of proteins and members of protein complexes involved in or required for different steps during the transport of proteins from the ribosome to the ER to the plasma membrane, via the Golgi apparatus. Examples are mu and sigma subunits of the heterotetrameric adaptor protein (AP) complex, zeta and delta subunits of the heterotetrameric F-COPI complex, a subgroup of R-SNARE proteins, a subfamily of the transport protein particle (TRAPP), and the signal recognition particle receptor subunit alpha (SR-alpha).


Pssm-ID: 341426  Cd Length: 117  Bit Score: 45.59  E-value: 8.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694312  24 HMMYVFNRNGVCLLYKEWNRplhtlnpqqDHKLMFGLLFSLKSLTAKMDPvnadkgnlgvpqlpgQGCSFHSFRTNTYKL 103
Cdd:cd14818     1 LQLAVFDPQGQVLAASNWLG---------KKPSVKFSLIQIKSFFSKLIT---------------SGFDFLTLTIGSYTF 56

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063694312 104 SFMETPsGIKIILVThpKTGDLRESLKYIYS-LYVEYVVKNPIYSPGSPI--KSELFNTALDQY 164
Cdd:cd14818    57 HYYLNK-GLYFVVIT--DEQELRQELFQTLNlLLKEFNSLHGSEVITKNIedDLEEFESYLDIK 117
TRAPPC2_sedlin cd14825
Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 ...
 108-166 1.28e-06

Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 (TRAPPC2), also known as Sedlin (SEDL) or TRS20, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic. In humans, deletions or point mutations in the SEDL gene cause the genetic disease spondyloepiphyseal dysplasia tarda (SEDT), an X-linked skeletal disorder.


Pssm-ID: 341429  Cd Length: 135  Bit Score: 45.21  E-value: 1.28e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063694312 108 TPSGIKIILVTHPKTGD-LRESLKYIYSLYVEYVVkNPIYSPGSPIKSELFNTALDQYVR 166
Cdd:cd14825    74 TAGNIRFLLLHDNKNDDgIKNFFQEVYELYVKILM-NPFYEPNTPIRSPAFDRRVRALAK 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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