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Conserved domains on  [gi|1063684199|ref|NP_001320953|]
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receptor like protein 2 [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1000136)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00113 super family cl33413
leucine-rich repeat receptor-like protein kinase; Provisional
 36-702 2.51e-84

leucine-rich repeat receptor-like protein kinase; Provisional


The actual alignment was detected with superfamily member PLN00113:

Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 287.13  E-value: 2.51e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199  36 ILFLSALFLTLSEAVCNLQDRESLIWFSGNVSSSVSPL-NWNLSIDCCSWEGITCDDSSdsHVTVISLPSRGLSGTLASS 114
Cdd:PLN00113   11 YLIFMLFFLFLNFSMLHAEELELLLSFKSSINDPLKYLsNWNSSADVCLWQGITCNNSS--RVVSIDLSGKNISGKISSA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 115 VQNIHRLSRLDLSYNRLSGPLPPGFFSTLDQLMILNLSYNSFNGELPLEQAFG----------------NESNRFFSIQT 178
Cdd:PLN00113   89 IFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNletldlsnnmlsgeipNDIGSFSSLKV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 179 LDLSSNLLEGEIlrsSVYLQGTINLISFNVSNNSFTGPIPSFMCRSSpQLSKLDFSYNDFSGHISQELGRCLRLTVLQAG 258
Cdd:PLN00113  169 LDLGGNVLVGKI---PNSLTNLTSLEFLTLASNQLVGQIPRELGQMK-SLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLV 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 259 FNNLSGVIPSEIYNLSELEQLFLPANQLTGKIDNNITRLRKLTSLALYSNHLEGEIPMDIGNLSSLRSLQLHINNINGTV 338
Cdd:PLN00113  245 YNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKI 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 339 PLSLANCTKLVKLNLRVNQLGGGLTElEFSQLQSLKVLDLGNNSFTGALPDKIFSCKSLTAIRFAGNKLTGEISPQVLEL 418
Cdd:PLN00113  325 PVALTSLPRLQVLQLWSNKFSGEIPK-NLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGAC 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 419 ESLSFMGLSDNkltNITGALSilQGCRKLSTLilakNFYDetvpskedflspdgfpklrifgVGACRLRGEIPAWLINLN 498
Cdd:PLN00113  404 RSLRRVRLQDN---SFSGELP--SEFTKLPLV----YFLD----------------------ISNNNLQGRINSRKWDMP 452

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 499 KVEVMDLSMNRFVGSIPGWLGTlPDLFYLDLSDNLLTGELPKELFQLRALMSQKITEnnylelpiflnpnnvttnqqynk 578
Cdd:PLN00113  453 SLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSE----------------------- 508

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 579 lysfpptiyirrNNLTGSIPVEVGQLKVLHILELLGNNLSGSIPDELSNLTNLERLDLSNNNLSGSIPWSLTNLNFLSYF 658
Cdd:PLN00113  509 ------------NKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQV 576

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 1063684199 659 NVANNSLEGPIPSEGQFDTFPKANFEGNPLLCGGVLLTSCKPTR 702
Cdd:PLN00113  577 NISHNHLHGSLPSTGAFLAINASAVAGNIDLCGGDTTSGLPPCK 620
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 36-702 2.51e-84

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 287.13  E-value: 2.51e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199  36 ILFLSALFLTLSEAVCNLQDRESLIWFSGNVSSSVSPL-NWNLSIDCCSWEGITCDDSSdsHVTVISLPSRGLSGTLASS 114
Cdd:PLN00113   11 YLIFMLFFLFLNFSMLHAEELELLLSFKSSINDPLKYLsNWNSSADVCLWQGITCNNSS--RVVSIDLSGKNISGKISSA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 115 VQNIHRLSRLDLSYNRLSGPLPPGFFSTLDQLMILNLSYNSFNGELPLEQAFG----------------NESNRFFSIQT 178
Cdd:PLN00113   89 IFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNletldlsnnmlsgeipNDIGSFSSLKV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 179 LDLSSNLLEGEIlrsSVYLQGTINLISFNVSNNSFTGPIPSFMCRSSpQLSKLDFSYNDFSGHISQELGRCLRLTVLQAG 258
Cdd:PLN00113  169 LDLGGNVLVGKI---PNSLTNLTSLEFLTLASNQLVGQIPRELGQMK-SLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLV 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 259 FNNLSGVIPSEIYNLSELEQLFLPANQLTGKIDNNITRLRKLTSLALYSNHLEGEIPMDIGNLSSLRSLQLHINNINGTV 338
Cdd:PLN00113  245 YNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKI 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 339 PLSLANCTKLVKLNLRVNQLGGGLTElEFSQLQSLKVLDLGNNSFTGALPDKIFSCKSLTAIRFAGNKLTGEISPQVLEL 418
Cdd:PLN00113  325 PVALTSLPRLQVLQLWSNKFSGEIPK-NLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGAC 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 419 ESLSFMGLSDNkltNITGALSilQGCRKLSTLilakNFYDetvpskedflspdgfpklrifgVGACRLRGEIPAWLINLN 498
Cdd:PLN00113  404 RSLRRVRLQDN---SFSGELP--SEFTKLPLV----YFLD----------------------ISNNNLQGRINSRKWDMP 452

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 499 KVEVMDLSMNRFVGSIPGWLGTlPDLFYLDLSDNLLTGELPKELFQLRALMSQKITEnnylelpiflnpnnvttnqqynk 578
Cdd:PLN00113  453 SLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSE----------------------- 508

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 579 lysfpptiyirrNNLTGSIPVEVGQLKVLHILELLGNNLSGSIPDELSNLTNLERLDLSNNNLSGSIPWSLTNLNFLSYF 658
Cdd:PLN00113  509 ------------NKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQV 576

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 1063684199 659 NVANNSLEGPIPSEGQFDTFPKANFEGNPLLCGGVLLTSCKPTR 702
Cdd:PLN00113  577 NISHNHLHGSLPSTGAFLAINASAVAGNIDLCGGDTTSGLPPCK 620
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
141-538 2.61e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 2.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 141 STLDQLMILNLSYNSFNGELPLEQAFGNESNRFFSIQTLDLSSNLLEGEILRSSVYLQGTINLISFNVSNNSFTGPIPSF 220
Cdd:COG4886    12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 221 MCRSsPQLSKLDFSYNDfsghisqELGRCLRLTVLQAGFNNLSgVIPSEIYNLSELEQLFLPANQLTgKIDNNITRLRKL 300
Cdd:COG4886    92 LGDL-TNLTELDLSGNE-------ELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 301 TSLALYSNHLEgEIPMDIGNLSSLRSLQLHINNINgTVPLSLANCTKLVKLNLRVNQlgggLTEL--EFSQLQSLKVLDL 378
Cdd:COG4886   162 KSLDLSNNQLT-DLPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQ----LTDLpePLANLTNLETLDL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 379 GNNSFTgALPDkIFSCKSLTAIRFAGNKLTGeiSPQVLELESLSFMGLSDNKLTNITGALSILQGCRKLSTLILAKNFYD 458
Cdd:COG4886   236 SNNQLT-DLPE-LGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 459 ETVPSKEDFLSPDGFPKLRIFGVGACRLRGEIPAWLINLNKVEVMDLSMNRFVGSIPGWLGTLPDLFYLDLSDNLLTGEL 538
Cdd:COG4886   312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 289-455 2.97e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 2.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 289 KIDNnITRLRKLTSLALYSNHLEgEIPmDIGNLSSLRSLQLHINNINGTVPLSlaNCTKLVKLNLRVNQLggglTELE-F 367
Cdd:cd21340    16 KIDN-LSLCKNLKVLYLYDNKIT-KIE-NLEFLTNLTHLYLQNNQIEKIENLE--NLVNLKKLYLGGNRI----SVVEgL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 368 SQLQSLKVLDLGNNSftgaLPDK---IFSCKSLTAIR-------FAGNKLTgeiSPQVLE-LESLSFMGLSDNKLTNITG 436
Cdd:cd21340    87 ENLTNLEELHIENQR----LPPGeklTFDPRSLAALSnslrvlnISGNNID---SLEPLApLRNLEQLDASNNQISDLEE 159

                         170
                  ....*....|....*....
gi 1063684199 437 ALSILQGCRKLSTLILAKN 455
Cdd:cd21340   160 LLDLLSSWPSLRELDLTGN 178
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 52-90 1.71e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 42.28  E-value: 1.71e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1063684199  52 NLQDRESLIWFSGNVSSSVSPL-NWNLS-IDCCSWEGITCD 90
Cdd:pfam08263   1 LNDDGQALLAFKSSLNDPPGALsSWNSSsSDPCSWTGVTCD 41
 
Name Accession Description Interval E-value
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 36-702 2.51e-84

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 287.13  E-value: 2.51e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199  36 ILFLSALFLTLSEAVCNLQDRESLIWFSGNVSSSVSPL-NWNLSIDCCSWEGITCDDSSdsHVTVISLPSRGLSGTLASS 114
Cdd:PLN00113   11 YLIFMLFFLFLNFSMLHAEELELLLSFKSSINDPLKYLsNWNSSADVCLWQGITCNNSS--RVVSIDLSGKNISGKISSA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 115 VQNIHRLSRLDLSYNRLSGPLPPGFFSTLDQLMILNLSYNSFNGELPLEQAFG----------------NESNRFFSIQT 178
Cdd:PLN00113   89 IFRLPYIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNletldlsnnmlsgeipNDIGSFSSLKV 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 179 LDLSSNLLEGEIlrsSVYLQGTINLISFNVSNNSFTGPIPSFMCRSSpQLSKLDFSYNDFSGHISQELGRCLRLTVLQAG 258
Cdd:PLN00113  169 LDLGGNVLVGKI---PNSLTNLTSLEFLTLASNQLVGQIPRELGQMK-SLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLV 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 259 FNNLSGVIPSEIYNLSELEQLFLPANQLTGKIDNNITRLRKLTSLALYSNHLEGEIPMDIGNLSSLRSLQLHINNINGTV 338
Cdd:PLN00113  245 YNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKI 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 339 PLSLANCTKLVKLNLRVNQLGGGLTElEFSQLQSLKVLDLGNNSFTGALPDKIFSCKSLTAIRFAGNKLTGEISPQVLEL 418
Cdd:PLN00113  325 PVALTSLPRLQVLQLWSNKFSGEIPK-NLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGAC 403

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 419 ESLSFMGLSDNkltNITGALSilQGCRKLSTLilakNFYDetvpskedflspdgfpklrifgVGACRLRGEIPAWLINLN 498
Cdd:PLN00113  404 RSLRRVRLQDN---SFSGELP--SEFTKLPLV----YFLD----------------------ISNNNLQGRINSRKWDMP 452

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 499 KVEVMDLSMNRFVGSIPGWLGTlPDLFYLDLSDNLLTGELPKELFQLRALMSQKITEnnylelpiflnpnnvttnqqynk 578
Cdd:PLN00113  453 SLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSE----------------------- 508

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 579 lysfpptiyirrNNLTGSIPVEVGQLKVLHILELLGNNLSGSIPDELSNLTNLERLDLSNNNLSGSIPWSLTNLNFLSYF 658
Cdd:PLN00113  509 ------------NKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQV 576

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....
gi 1063684199 659 NVANNSLEGPIPSEGQFDTFPKANFEGNPLLCGGVLLTSCKPTR 702
Cdd:PLN00113  577 NISHNHLHGSLPSTGAFLAINASAVAGNIDLCGGDTTSGLPPCK 620
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
141-538 2.61e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 2.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 141 STLDQLMILNLSYNSFNGELPLEQAFGNESNRFFSIQTLDLSSNLLEGEILRSSVYLQGTINLISFNVSNNSFTGPIPSF 220
Cdd:COG4886    12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 221 MCRSsPQLSKLDFSYNDfsghisqELGRCLRLTVLQAGFNNLSgVIPSEIYNLSELEQLFLPANQLTgKIDNNITRLRKL 300
Cdd:COG4886    92 LGDL-TNLTELDLSGNE-------ELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 301 TSLALYSNHLEgEIPMDIGNLSSLRSLQLHINNINgTVPLSLANCTKLVKLNLRVNQlgggLTEL--EFSQLQSLKVLDL 378
Cdd:COG4886   162 KSLDLSNNQLT-DLPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQ----LTDLpePLANLTNLETLDL 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 379 GNNSFTgALPDkIFSCKSLTAIRFAGNKLTGeiSPQVLELESLSFMGLSDNKLTNITGALSILQGCRKLSTLILAKNFYD 458
Cdd:COG4886   236 SNNQLT-DLPE-LGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 459 ETVPSKEDFLSPDGFPKLRIFGVGACRLRGEIPAWLINLNKVEVMDLSMNRFVGSIPGWLGTLPDLFYLDLSDNLLTGEL 538
Cdd:COG4886   312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
252-663 3.76e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.52  E-value: 3.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 252 LTVLQAGFNNLSGVIPSEIYNLSELEQLFLPANQLTGKIDNNITRLRKLTSLALYSNHLEGeiPMDIGNLSSLRSLQLHI 331
Cdd:COG4886    28 LLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG--LTDLGDLTNLTELDLSG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 332 NNingtvplSLANCTKLVKLNLRVNQLggglTEL--EFSQLQSLKVLDLGNNSFTgALPDKIFSCKSLTAIRFAGNKLTg 409
Cdd:COG4886   106 NE-------ELSNLTNLESLDLSGNQL----TDLpeELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLT- 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 410 EISPQVLELESLSFMGLSDNKLTNITGALSilqGCRKLSTLILAKNfydeTVPSKEDFLSpdGFPKLRIFGVGACRLRgE 489
Cdd:COG4886   173 DLPEELGNLTNLKELDLSNNQITDLPEPLG---NLTNLEELDLSGN----QLTDLPEPLA--NLTNLETLDLSNNQLT-D 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 490 IPaWLINLNKVEVMDLSMNRfVGSIPGwLGTLPDLFYLDLSDNLLTGELPKELFQLRALMSQKITENNYLELPIFLNPNN 569
Cdd:COG4886   243 LP-ELGNLTNLEELDLSNNQ-LTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLL 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 570 VTTNQQYNKLYSF-PPTIYIRRNNLTGSIPVEVGQLKVLHILELLGNNLSGSIPDELSNLTNLERLDLSNNNLSGSIPWS 648
Cdd:COG4886   320 LTTLLLLLLLLKGlLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399

                         410
                  ....*....|....*
gi 1063684199 649 LTNLNFLSYFNVANN 663
Cdd:COG4886   400 VLLLTLALLDAVNTE 414
PLN03150 PLN03150
hypothetical protein; Provisional
 593-730 1.39e-15

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 80.63  E-value: 1.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 593 LTGSIPVEVGQLKVLHILELLGNNLSGSIPDELSNLTNLERLDLSNNNLSGSIPWSLTNLNFLSYFNVANNSLEGPIPSE 672
Cdd:PLN03150  430 LRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAA 509

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 673 --GQFDTFPKANFEGNPLLCGGVLLTSCKPTrakendeLNRTFLMGIAIGYFLSFVSILV 730
Cdd:PLN03150  510 lgGRLLHRASFNFTDNAGLCGIPGLRACGPH-------LSVGAKIGIAFGVSVAFLFLVI 562
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
361-688 7.90e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 7.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 361 GLTELEFSQLQSLKVLDLGNNSFTGALPDKIFSCKSLTAIRFAGNKLTGEISPQVLELESLSFMGLSDNKLTNITGALSI 440
Cdd:COG4886    12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 441 LQGCRKLSTLILAKNFYDEtvpskedflspdGFPKLRIFGVGACRLRgEIPAWLINLNKVEVMDLSMNRFvGSIPGWLGT 520
Cdd:COG4886    92 LGDLTNLTELDLSGNEELS------------NLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQL-TDLPEPLGN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 521 LPDLFYLDLSDNLLTgELPKELFQLRALMSqkitennylelpiflnpnnvttnqqynklysfpptIYIRRNNLTgSIPVE 600
Cdd:COG4886   158 LTNLKSLDLSNNQLT-DLPEELGNLTNLKE-----------------------------------LDLSNNQIT-DLPEP 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 601 VGQLKVLHILELLGNNLSgSIPDELSNLTNLERLDLSNNNLSgSIPWsLTNLNFLSYFNVANNSLEGpIPSEGQFDTFPK 680
Cdd:COG4886   201 LGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLT-DLPE-LGNLTNLEELDLSNNQLTD-LPPLANLTNLKT 276


                  ....*...
gi 1063684199 681 ANFEGNPL 688
Cdd:COG4886   277 LDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
259-666 2.06e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 2.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 259 FNNLSGVIPSEIYNLSELEQLFLPANQLTGKIDNNITRLRKLTSLALYSNHLEGEIPMDIGNLSSLRSLQLHINNINGTV 338
Cdd:COG4886     9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 339 PLSLANCTKLVKLNLRVNQlgggltelEFSQLQSLKVLDLGNNSFTgALPDKIFSCKSLTAIRFAGNKLTgEISPQVLEL 418
Cdd:COG4886    89 LTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLT-DLPEPLGNL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 419 ESLSFMGLSDNKLTNITGALSilqGCRKLSTLILAKNFYDEtvpskedfLSPD--GFPKLRIFGVGACRLRgEIPAWLIN 496
Cdd:COG4886   159 TNLKSLDLSNNQLTDLPEELG---NLTNLKELDLSNNQITD--------LPEPlgNLTNLEELDLSGNQLT-DLPEPLAN 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 497 LNKVEVMDLSMNRFVgSIPgWLGTLPDLFYLDLSDNLLTgELPkELFQLRALMSQKITENNYLELPI-FLNPNNVTTNQQ 575
Cdd:COG4886   227 LTNLETLDLSNNQLT-DLP-ELGNLTNLEELDLSNNQLT-DLP-PLANLTNLKTLDLSNNQLTDLKLkELELLLGLNSLL 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 576 YNKLYSFPPTIYIRRNNLTGSIPVEVGQLKVLHILELLGNNLSGSIPDELSNLTNLERLDLSNNNLSGSIPWSLTNLNFL 655
Cdd:COG4886   303 LLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTL 382

                         410
                  ....*....|.
gi 1063684199 656 SYFNVANNSLE 666
Cdd:COG4886   383 ALLLLTLLLLL 393
PLN03150 PLN03150
hypothetical protein; Provisional
 284-360 3.97e-13

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 72.93  E-value: 3.97e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063684199 284 NQ-LTGKIDNNITRLRKLTSLALYSNHLEGEIPMDIGNLSSLRSLQLHINNINGTVPLSLANCTKLVKLNLRVNQLGG 360
Cdd:PLN03150  427 NQgLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSG 504
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
31-452 6.90e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 6.90e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199  31 LFLLCILFLSALFLTLSEAVCNLQDRESLIWFSGNVSSSVSPLNWNLSIDCCSWEGITCDDSSDSHVTVISLPSRGLSGT 110
Cdd:COG4886     8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 111 LASSVQNIHRLSRLDLSYNRlsgplppgFFSTLDQLMILNLSYNSFNgELPLEQAfgnesnRFFSIQTLDLSSNLLEgEI 190
Cdd:COG4886    88 GLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLT-DLPEELA------NLTNLKELDLSNNQLT-DL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 191 LRSsvyLQGTINLISFNVSNNSFTGpIPSFMCrSSPQLSKLDFSYNDFSgHISQELGRCLRLTVLQAGFNNLSgVIPSEI 270
Cdd:COG4886   152 PEP---LGNLTNLKSLDLSNNQLTD-LPEELG-NLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLT-DLPEPL 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 271 YNLSELEQLFLPANQLTGKIdnNITRLRKLTSLALYSNHLEgEIPmDIGNLSSLRSLQLHINNINGTVPLSLANCTKLVK 350
Cdd:COG4886   225 ANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLT-DLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 351 LNLRVNQLGGGLTELEFSQLQ------SLKVLDLGNNSFTGALPDKIFSCKSLTAIRFAGNKLTGEISPQVLELESLSFM 424
Cdd:COG4886   301 LLLLLLLLNLLELLILLLLLTtlllllLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLL 380

                         410       420
                  ....*....|....*....|....*...
gi 1063684199 425 GLSDNKLTNITGALSILQGCRKLSTLIL 452
Cdd:COG4886   381 TLALLLLTLLLLLLTTTAGVLLLTLALL 408
PLN03150 PLN03150
hypothetical protein; Provisional
 39-218 8.24e-12

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 68.69  E-value: 8.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199  39 LSALFLTLSEAVCNLQDRESLIWFSgnvsssvSPLNWNLsiDCCS-----WEGITCD-DSSDSH--VTVISLPSRGLSGT 110
Cdd:PLN03150  363 ITAESKTLLEEVSALQTLKSSLGLP-------LRFGWNG--DPCVpqqhpWSGADCQfDSTKGKwfIDGLGLDNQGLRGF 433

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 111 LASSVQNIHRLSRLDLSYNRLSGPLPPGfFSTLDQLMILNLSYNSFNGELPleQAFGnesnRFFSIQTLDLSSNLLEGEI 190
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRGNIPPS-LGSITSLEVLDLSYNSFNGSIP--ESLG----QLTSLRILNLNGNSLSGRV 506

                         170       180       190
                  ....*....|....*....|....*....|
gi 1063684199 191 LRS--SVYLQGTinliSFNVSNNSFTGPIP 218
Cdd:PLN03150  507 PAAlgGRLLHRA----SFNFTDNAGLCGIP 532
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
308-667 6.56e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 6.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 308 NHLEGEIPMDIGNLSSLRSLQLHINNINGTVPLSLANCTKLVKLNLRVNQLGGGLTELEFSQLQSLKVLDLGNNSFTGAL 387
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 388 PDKIFSCKSLTAIRFAGNKLTGEISPQVLELESLSFMGLSDNKLTNITGALSilqGCRKLSTLILAKNfydetvpskedf 467
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELA---NLTNLKELDLSNN------------ 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 468 lspdgfpKLRifgvgacrlrgEIPAWLINLNKVEVMDLSMNRfVGSIPGWLGTLPDLFYLDLSDNLLTgELPKELFQLRA 547
Cdd:COG4886   147 -------QLT-----------DLPEPLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTN 206

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 548 LmsqkitennylelpiflnpnnvttnqqynklysfpPTIYIRRNNLTgSIPVEVGQLKVLHILELLGNNLSgSIPdELSN 627
Cdd:COG4886   207 L-----------------------------------EELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLT-DLP-ELGN 248

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1063684199 628 LTNLERLDLSNNNLSgSIPwSLTNLNFLSYFNVANNSLEG 667
Cdd:COG4886   249 LTNLEELDLSNNQLT-DLP-PLANLTNLKTLDLSNNQLTD 286
PLN03150 PLN03150
hypothetical protein; Provisional
 303-388 2.86e-10

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 63.68  E-value: 2.86e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 303 LALYSNHLEGEIPMDIGNLSSLRSLQLHINNINGTVPLSLANCTKLVKLNLRVNQLGGGLTElEFSQLQSLKVLDLGNNS 382
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPE-SLGQLTSLRILNLNGNS 501


                  ....*.
gi 1063684199 383 FTGALP 388
Cdd:PLN03150  502 LSGRVP 507
PLN03150 PLN03150
hypothetical protein; Provisional
 258-342 6.30e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 59.06  E-value: 6.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 258 GFNN--LSGVIPSEIYNLSELEQLFLPANQLTGKIDNNITRLRKLTSLALYSNHLEGEIPMDIGNLSSLRSLQLHINNIN 335
Cdd:PLN03150  424 GLDNqgLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503


                  ....*..
gi 1063684199 336 GTVPLSL 342
Cdd:PLN03150  504 GRVPAAL 510
PLN03150 PLN03150
hypothetical protein; Provisional
 470-542 7.29e-09

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 59.06  E-value: 7.29e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063684199 470 PDGFPKLR---IFGVGACRLRGEIPAWLINLNKVEVMDLSMNRFVGSIPGWLGTLPDLFYLDLSDNLLTGELPKEL 542
Cdd:PLN03150  435 PNDISKLRhlqSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAAL 510
PLN03150 PLN03150
hypothetical protein; Provisional
 610-688 6.10e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 55.98  E-value: 6.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 610 LELLGNNLSGSIPDELSNLTNLERLDLSNNNLSGSIPWSLTNLNFLSYFNVANNSLEGPIP-SEGQFDTFPKANFEGNPL 688
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPeSLGQLTSLRILNLNGNSL 502
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 289-455 2.97e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 2.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 289 KIDNnITRLRKLTSLALYSNHLEgEIPmDIGNLSSLRSLQLHINNINGTVPLSlaNCTKLVKLNLRVNQLggglTELE-F 367
Cdd:cd21340    16 KIDN-LSLCKNLKVLYLYDNKIT-KIE-NLEFLTNLTHLYLQNNQIEKIENLE--NLVNLKKLYLGGNRI----SVVEgL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 368 SQLQSLKVLDLGNNSftgaLPDK---IFSCKSLTAIR-------FAGNKLTgeiSPQVLE-LESLSFMGLSDNKLTNITG 436
Cdd:cd21340    87 ENLTNLEELHIENQR----LPPGeklTFDPRSLAALSnslrvlnISGNNID---SLEPLApLRNLEQLDASNNQISDLEE 159

                         170
                  ....*....|....*....
gi 1063684199 437 ALSILQGCRKLSTLILAKN 455
Cdd:cd21340   160 LLDLLSSWPSLRELDLTGN 178
PLN03150 PLN03150
hypothetical protein; Provisional
 165-270 8.91e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.13  E-value: 8.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 165 AFGNESNRFFsIQTLDLSSNLLEGEILRSSVYLQgtiNLISFNVSNNSFTGPIPSFMcRSSPQLSKLDFSYNDFSGHISQ 244
Cdd:PLN03150  410 QFDSTKGKWF-IDGLGLDNQGLRGFIPNDISKLR---HLQSINLSGNSIRGNIPPSL-GSITSLEVLDLSYNSFNGSIPE 484

                          90       100
                  ....*....|....*....|....*.
gi 1063684199 245 ELGRCLRLTVLQAGFNNLSGVIPSEI 270
Cdd:PLN03150  485 SLGQLTSLRILNLNGNSLSGRVPAAL 510
PLN03150 PLN03150
hypothetical protein; Provisional
 486-548 3.90e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.20  E-value: 3.90e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063684199 486 LRGEIPAWLINLNKVEVMDLSMNRFVGSIPGWLGTLPDLFYLDLSDNLLTGELPKELFQLRAL 548
Cdd:PLN03150  430 LRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSL 492
LRRNT_2 pfam08263
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 52-90 1.71e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 462411 [Multi-domain]  Cd Length: 41  Bit Score: 42.28  E-value: 1.71e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1063684199  52 NLQDRESLIWFSGNVSSSVSPL-NWNLS-IDCCSWEGITCD 90
Cdd:pfam08263   1 LNDDGQALLAFKSSLNDPPGALsSWNSSsSDPCSWTGVTCD 41
PLN03150 PLN03150
hypothetical protein; Provisional
 207-290 1.17e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.58  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 207 NVSNNSFTGPIPSFMCRSSpQLSKLDFSYNDFSGHISQELGRCLRLTVLQAGFNNLSGVIPSEIYNLSELEQLFLPANQL 286
Cdd:PLN03150  424 GLDNQGLRGFIPNDISKLR-HLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                  ....
gi 1063684199 287 TGKI 290
Cdd:PLN03150  503 SGRV 506
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
95-387 1.75e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.54  E-value: 1.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199  95 SHVTVISLPSRGLSgTLASSVQNIHRLSRLDLSYNRLSGpLPPgFFSTLDQLMILNLSYNSFNgELPLEqaFGNESNrff 174
Cdd:COG4886   136 TNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLTD-LPE-ELGNLTNLKELDLSNNQIT-DLPEP--LGNLTN--- 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 175 sIQTLDLSSNLLEgEIlrsSVYLQGTINLISFNVSNNSFTgPIPSFmcRSSPQLSKLDFSYNDFSgHISqELGRCLRLTV 254
Cdd:COG4886   207 -LEELDLSGNQLT-DL---PEPLANLTNLETLDLSNNQLT-DLPEL--GNLTNLEELDLSNNQLT-DLP-PLANLTNLKT 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 255 LQAGFNNLSGVIPSEIYNLSELEQLFLPANQLTGKIDNNITRLRKLTSLALYSNHLEGEIPMDIGNLSSLRSLQLHINNI 334
Cdd:COG4886   277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLL 356

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063684199 335 NGTVPLSLANCTKLVKLNLRVNQLGGGLTELEFSQLQSLKVLDLGNNSFTGAL 387
Cdd:COG4886   357 NLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 299-432 2.15e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 2.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 299 KLTSLALYSNHLEGEIPMDIGNL----SSLRSLQLHINNING----TVPLSLANCTKLVKLNLRVNQL---GGGLTELEF 367
Cdd:cd00116   138 ALEKLVLGRNRLEGASCEALAKAlranRDLKELNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLtdeGASALAETL 217

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063684199 368 SQLQSLKVLDLGNNSFTGA-----LPDKIFSCKSLTAIRFAGNKLTGEISPQVLEL----ESLSFMGLSDNKLT 432
Cdd:cd00116   218 ASLKSLEVLNLGDNNLTDAgaaalASALLSPNISLLTLSLSCNDITDDGAKDLAEVlaekESLLELDLRGNKFG 291
LRR_8 pfam13855
Leucine rich repeat;
120-186 2.83e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 2.83e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063684199 120 RLSRLDLSYNRLSGpLPPGFFSTLDQLMILNLSYNSFNGELPleQAFGNESnrffSIQTLDLSSNLL 186
Cdd:pfam13855   2 NLRSLDLSNNRLTS-LDDGAFKGLSNLKVLDLSNNLLTTLSP--GAFSGLP----SLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 607-663 6.96e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.70  E-value: 6.96e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063684199 607 LHILELLGNNLSgsIPDELSNLTNLERLDLSNNNLS--GSIPWSLTNLNFLSYFNVANN 663
Cdd:cd21340   122 LRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISdlEELLDLLSSWPSLRELDLTGN 178
PLN03150 PLN03150
hypothetical protein; Provisional
 368-432 7.12e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 7.12e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063684199 368 SQLQSLKVLDLGNNSFTGALPDKIFSCKSLTAIRFAGNKLTGEISPQVLELESLSFMGLSDNKLT 432
Cdd:PLN03150  439 SKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
PLN03150 PLN03150
hypothetical protein; Provisional
 240-319 8.17e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 8.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 240 GHISQELGRCLRLTVLQAGFNNLSGVIPSEIYNLSELEQLFLPANQLTGKIDNNITRLRKLTSLALYSNHLEGEIPMDIG 319
Cdd:PLN03150  432 GFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALG 511
LRR_8 pfam13855
Leucine rich repeat;
607-665 1.59e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063684199 607 LHILELLGNNLSGSIPDELSNLTNLERLDLSNNNLSGSIPWSLTNLNFLSYFNVANNSL 665
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
585-641 4.04e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 4.04e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 585 TIYIRRNNLTGsipVEVGQLKVLHILELL---GNNLSGSIPDELSNLTNLERLDLSNNNL 641
Cdd:pfam13855   5 SLDLSNNRLTS---LDDGAFKGLSNLKVLdlsNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
474-534 5.17e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 5.17e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063684199 474 PKLRIFGVGACRLRGEIPAWLINLNKVEVMDLSMNRFVGSIPGWLGTLPDLFYLDLSDNLL 534
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 295-455 9.47e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.00  E-value: 9.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 295 TRLRKLTSLALYSNHLEGEIPMDIGNL----SSLRSLQLHINNI--NGTVPLS--LANCTKLVKLNLRVNQLGG-GLTEL 365
Cdd:COG5238   233 KGNKSLTTLDLSNNQIGDEGVIALAEAlknnTTVETLYLSGNQIgaEGAIALAkaLQGNTTLTSLDLSVNRIGDeGAIAL 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684199 366 E--FSQLQSLKVLDLGNNSFTG----ALPDKIFSCKSLTAIRFAGNKLTGE----ISPQVLELESLSFMGLSDNKLTNiT 435
Cdd:COG5238   313 AegLQGNKTLHTLNLAYNGIGAqgaiALAKALQENTTLHSLDLSDNQIGDEgaiaLAKYLEGNTTLRELNLGKNNIGK-Q 391

                         170       180
                  ....*....|....*....|..
gi 1063684199 436 GALSILQGCR--KLSTLILAKN 455
Cdd:COG5238   392 GAEALIDALQtnRLHTLILDGN 413
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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