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Conserved domains on  [gi|1063693952|ref|NP_001320408|]
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calcium-dependent lipid-binding family protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
139-381 2.33e-82

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


:

Pssm-ID: 465309  Cd Length: 234  Bit Score: 271.44  E-value: 2.33e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  139 WLGSIIATIIGNLKVSISNVHIRYEDSTSNPGHPFAAGITLAKLAAVTMDEEGNETFDTSGAlDKLRKSLQLERLALYHD 218
Cdd:pfam16908    1 FTESLITKIIDNLQVTIKNIHIRYEDSVSNPGHPFAFGITLEELSAQSTDENWKPTFIQGTS-KIIHKLVELESLSVYWD 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  219 SNSfpwEIEKQWDNITPEEWIEMFEDGIKEQTEHKIkskwalNRHYLLSPINGSLKYHRlgNQERNNPEIPFERASVILN 298
Cdd:pfam16908   80 TDS---ESLELLGDLDLEELLEKFKSLIASKSNKPP------DHQYILKPVSGSAKLTL--NKKGETETIPKIDLDLEFD 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  299 DVNVTITEEQYHDWIKLVEVVSRYKTYIEISHLRPMVPVSEAPRLWWRFAAQASLQQKRLC-YRFSWDSIHHLCQLRRRY 377
Cdd:pfam16908  149 EIGLTLDDRQYRDILSLLDSFHRFLRRQKYRKYRPKVSVKENPRAWWKYAINAVLEEIRERrRKWSWDYIKKRRDDRKEY 228

                   ....
gi 1063693952  378 IQLY 381
Cdd:pfam16908  229 IELY 232
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
1-830 3.27e-58

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 225.53  E-value: 3.27e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952    1 MFEAHVLHLLRRYLGEYVHGLSTEALRISVWKGDVVLKDLKLKAEALNSLKLPVAVKSGFVGTITLKVPWKSLGKEPVIV 80
Cdd:COG5043      1 MLEGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952   81 LIDRVFVLAYPAPDDRTLKEEDREKLLETKLQQIEEAETATLEARAKSKLGSPPQGNSWLGSIIATIIGNLKVSISNVHI 160
Cdd:COG5043     81 YIEDIYLLISPQAKNSLTREELPQSQQALKQRQLDSWEILRETLEESSSSPNISRKQSFIESLITKLIDNIQIYIEDIHL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  161 RYEDSTSN--PGhPFAAGITLAKLAAVTMDEEGNETF--DTSGALDKLrksLQLERLALYhdsnsfPWEIEKQWDNITPE 236
Cdd:COG5043    161 RFEDNLSAdlEG-PYSFGLTLYSLRATSTDASWTEYFvsTDSSCIHKL---ITLDYFSIY------WCEISPCITTEDID 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  237 EWIEMFEDGIKEqtehKIKSKwalnRHYLLSPINGSLKyhrLGNQERNNPEIPFERASVILNDVNVTITEEQYHD----- 311
Cdd:COG5043    231 SYLENFQPMIAE----KSPAY----NEYILKPVRGTAK---VSINKLPTDEIPRLRGQLSVEEFSISLSDHMYYSllgvl 299
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  312 -WIKLVEVVSRYKTYIEIShlrpmvPVSEAPRLWWRFAAQASL---QQKRlcYRFSWDSIHHLCQLRRRYIQLYANFL-- 385
Cdd:COG5043    300 dYLQVVMKQQKFLKYRPKS------TPKEKPLEWFKYIILVVLdsiHEKR--YHWTWKYFKERCEDRRAYMKIIRKKYln 371
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  386 -QQSSDVNYP-EMREIEKDLDSKVILLWRLLAhakvesvksKEAAEQRKL----KKGGWFSFNW--RTEAEDDpevDSVA 457
Cdd:COG5043    372 eQLSADLSKElEKRELTYDLIKYRSRLFRSLA---------KRRNSIYLKpqthKLQGWFSGLWngKPQAQDE---DTLA 439
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  458 GGSKlmeerlTKDEWKAI---NKLLSHQPdeemnlySGKDMQNMTHFLVTVSIGQGAARIVDINQTEVLcGRFEQLDVTT 534
Cdd:COG5043    440 STDK------TAAELTDQeqkDFFSEIEP-------VGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINL-ISQRFENFKS 505
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  535 KFrhrstqcdvSLRFYGLS--APEGSLaQSVSSERKTNALMASFVNAPIGENIDWRLSATISP------------CHATI 600
Cdd:COG5043    506 KF---------SLNKLDLFdgATNPEL-KPYRSIRNKPKVRESESLQEIEEESRTHLFASFEDskpdgkasstliIHLRT 575
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  601 WTESYDRVLEFVKRSNAVSPTVALETAAVL----QMKLEEVTRRAQEQLQIVLEEQSRFALDIDIDAPKVRIPLRASGSS 676
Cdd:COG5043    576 LVIFYNRVCILSVLKFFVPSRTKIEHVSEWvysaAATVMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPEDCTDPK 655
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  677 kcSSHFLLDFGNFTLTT--MDTRSEEQRQNL-------YSRFCISGRDIAAFftdCGSDNQGcslVMEdftnqpilspiL 747
Cdd:COG5043    656 --SPTLFLDAGRISIHSqlVEDAIIKKFRELqtlenlmYDRFTISLFNVRCL---IGPDYEG---KRE-----------L 716
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  748 EKADNVYSLIDRCGMAVIVDQIKVPH-PSYPSTRISIQVPNIGVHFSPTRYMRIMQLfdilygAMKTYSQAPVDHMPDGI 826
Cdd:COG5043    717 PKGKCDYHILKELKLEINVEISILPKaTNLPKIKVSGHMPHASLMFSDVQYKVIINL------MSNILPTISVDEINGDY 790

                   ....
gi 1063693952  827 QPWS 830
Cdd:COG5043    791 QQFS 794
MRS6 super family cl34879
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3542-4006 6.22e-26

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5043:

Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 118.83  E-value: 6.22e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3542 SHLLASEDSEFHVIVELAELGISVIDHAPEEILYMSVQNLFVAYSTGlgSGLSRFKLRMQGIQVDNQLPLAPMPVLFRP- 3620
Cdd:COG5043   1984 MKLDSGADLEVKGVLLLKGVGISLIDRKDQELAYMTNVGIGLRFIDS--KAYQTFSWECAWVQIDNQLVLGIYPVILYPt 2061
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3621 ----QRTGDKADYIL--KFSVTLQSNAGLDLRVYPYIDFQG---RENTAFLINIHEPI-----IW----RIHEMIQQANL 3682
Cdd:COG5043   2062 eisqEEKEIENHLLPsrKFAVVKDSDSAVTYDKYVTILLQElsiELDEDLALAYLEKLkfpgsKYmddkKFDDEIELPDI 2141
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3683 srlsDPNSTAVSVdpFIQIgvLNFSEVRFRVSMA----MSPSQRPRGVLGFWSS-----LMTALGNTENMPVRISERFHE 3753
Cdd:COG5043   2142 ----IINKSGSNI--YFEF--LHLQPTRLHISFSrsseSSGEDGKVVPSSNSYSdfygmLAMTLGNINDAPVRLNSLLMD 2213
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3754 NISMRQSTMIN--------NAIRNVKK-----DLLGQPLQLL----SGV-----------------------------DI 3787
Cdd:COG5043   2214 NARVSLPELFDliashylqQVEYQIYKilgsaDFLGNPVGLFetvsSGVsdlfyepyqgrflvdnsqewgigiakggnSF 2293
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3788 LGNA--------SSALGHMSQGIAALSMDKKFIQSR--QRQENKGVEDFgDIIREGGGALAKGLFRGVTGILTKPLEGAK 3857
Cdd:COG5043   2294 IKKTiygvsdsvSKFTGSISKGLSLVTSDPELQSSRrlVRRRNRPKGSV-YGVTAGATSLYDSTSSGEKGLALEPIIGAA 2372
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3858 SSGVEGFVSGFGKGIIGAAAQPVSGVLDLLSKTTEGAnamrmKIAAAITSDEQLLRRRLPRAVGADSLLRPYNDYRAQGQ 3937
Cdd:COG5043   2373 TNGASGFVKGLGKGILGLETKPLVGFLDLTSNDSEGI-----KNTTTVLDYHDIPRLRLPRYVWDDGCVAPYDLRESQGQ 2447
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063693952 3938 VILQlaesgSFLGqvdlfkvrGKFALtDAYESHFILPKGKVLMITHRRVILLQQPSNIMgqrKFIPAKD 4006
Cdd:COG5043   2448 YWLK-----TLDA--------GKYPL-DEYKFHDIINNVAVIISRDIHAIVTSKILILK---DYIPSKA 2499
Vps62 super family cl05569
Vacuolar protein sorting-associated protein 62; Vps62 is a vacuolar protein sorting (VPS) ...
2013-2171 8.32e-08

Vacuolar protein sorting-associated protein 62; Vps62 is a vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins.


The actual alignment was detected with superfamily member pfam06101:

Pssm-ID: 461828  Cd Length: 539  Bit Score: 58.40  E-value: 8.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 2013 IPLASCTNFDRIWvSPKENGPRNN-LTIWRPQA-PSNYVILG------------------DCVTSRAIPPTqavmavsnt 2072
Cdd:pfam06101   29 LEVAQISTFEKVW-STYEGGPDNKgATFYEPSGiPEGFFCLGhycqpnnqplfgwvlvarDVSASKPEGPA--------- 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 2073 ygrVRKPIGFNRIGLFsviqglegdnvqHSHNSNECS---LWMPVAPVGYTAMGCVANIGSEQPPDHIVYCLRSDLVSSS 2149
Cdd:pfam06101   99 ---LKKPLDYTLVWSS------------NSLKIKQDGcgyFWLPVPPEGYKAVGHVVTTSPEKPSLDEVRCVRADLTDQC 163
                          170       180
                   ....*....|....*....|..
gi 1063693952 2150 SFSECIYTVPSSSLfESGFSIW 2171
Cdd:pfam06101  164 ETDRLIWGTGSKSP-KNGFNVW 184
C2 cd00030
C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed ...
2648-2754 3.59e-06

C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


:

Pssm-ID: 175973 [Multi-domain]  Cd Length: 102  Bit Score: 48.22  E-value: 3.59e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 2648 MTVQILEAKGLHIIDDGNSHSFFCTLRLVVDsqgaepqklfpQSARTKCVKPSTTIVndlmectskWNELFIFEIPRKGV 2727
Cdd:cd00030      1 LRVTVIEARNLPAKDLNGKSDPYVKVSLGGK-----------QKFKTKVVKNTLNPV---------WNETFEFPVLDPES 60
                           90       100
                   ....*....|....*....|....*..
gi 1063693952 2728 ARLEVEVTNlAAKAGKGEVVGSLSFPV 2754
Cdd:cd00030     61 DTLTVEVWD-KDRFSKDDFLGEVEIPL 86
Vps62 super family cl05569
Vacuolar protein sorting-associated protein 62; Vps62 is a vacuolar protein sorting (VPS) ...
2251-2370 3.86e-06

Vacuolar protein sorting-associated protein 62; Vps62 is a vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins.


The actual alignment was detected with superfamily member pfam06101:

Pssm-ID: 461828  Cd Length: 539  Bit Score: 53.00  E-value: 3.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 2251 VSTpnFERIW-WDKGGDLRRPVSIWRPVPRP-GFAILG------------------DSITEGLEPPALgilfkaddseia 2310
Cdd:pfam06101   34 IST--FEKVWsTYEGGPDNKGATFYEPSGIPeGFFCLGhycqpnnqplfgwvlvarDVSASKPEGPAL------------ 99
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063693952 2311 AKPVQFNKV---AHIVGKGFDEVFCWFPVAPPGYVSLGCVLSKFDEAPHVDSFCCPRIDLVNQ 2370
Cdd:pfam06101  100 KKPLDYTLVwssNSLKIKQDGCGYFWLPVPPEGYKAVGHVVTTSPEKPSLDEVRCVRADLTDQ 162
SHR-BD super family cl05933
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
3145-3452 1.33e-05

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


The actual alignment was detected with superfamily member pfam06650:

Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 50.00  E-value: 1.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3145 TIRFFVPYWITNDSYLPLSYRvveiepsenveagspcltraSKSFKKNPVFSMERRHQKKNVrvlesiedtspMPSMLS- 3223
Cdd:pfam06650    2 KVSIYSPYVILNKTGLPLIVR--------------------SKGNKNKAAGTLESHEGGRRL-----------IPLMFSf 50
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3224 PQESAGRSGVVLfpSQKDSYVSPRIGI-------AVAARDSDSYSP---GISLLELEKKeridvkafckdasyYMLsavl 3293
Cdd:pfam06650   51 DTFDDRKNRALL--RIGDSSWSKPFSFdaigqtnDVVLPSPNGQNEvylGISVSEGRGK--------------YKL---- 110
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3294 nmtsdrTKVIHLQPHTLFINRVGVSICLQQCDCQTEEWINPSDpPKLFGWQSSTRLELLKLRVKG--YRWSTPFSVFSEG 3371
Cdd:pfam06650  111 ------TKIVTIAPRFIIKNKLPEDLEIREPGSSKIISLPPGE-LIPLHWLRNVEEKQLCIRFPGsnSQWSSPFNISDVG 183
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3372 TMRVPVPKEDGTDQLqLRVQVRSgtKNSRYEVIFRPNSISGPYRIENRS--------------------MFLPIRYRqve 3431
Cdd:pfam06650  184 STYVKVRRQNSGQKL-LKVEIIL--EDATIFIRIEDEDNNWPFSIRNFSdvefifyqrnpnlnsdgennEYKPIYYR--- 257
                          330       340
                   ....*....|....*....|.
gi 1063693952 3432 gvseswqfLPPNAAASFYWEN 3452
Cdd:pfam06650  258 --------LPPKSVMPYAWDY 270
 
Name Accession Description Interval E-value
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
139-381 2.33e-82

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


Pssm-ID: 465309  Cd Length: 234  Bit Score: 271.44  E-value: 2.33e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  139 WLGSIIATIIGNLKVSISNVHIRYEDSTSNPGHPFAAGITLAKLAAVTMDEEGNETFDTSGAlDKLRKSLQLERLALYHD 218
Cdd:pfam16908    1 FTESLITKIIDNLQVTIKNIHIRYEDSVSNPGHPFAFGITLEELSAQSTDENWKPTFIQGTS-KIIHKLVELESLSVYWD 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  219 SNSfpwEIEKQWDNITPEEWIEMFEDGIKEQTEHKIkskwalNRHYLLSPINGSLKYHRlgNQERNNPEIPFERASVILN 298
Cdd:pfam16908   80 TDS---ESLELLGDLDLEELLEKFKSLIASKSNKPP------DHQYILKPVSGSAKLTL--NKKGETETIPKIDLDLEFD 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  299 DVNVTITEEQYHDWIKLVEVVSRYKTYIEISHLRPMVPVSEAPRLWWRFAAQASLQQKRLC-YRFSWDSIHHLCQLRRRY 377
Cdd:pfam16908  149 EIGLTLDDRQYRDILSLLDSFHRFLRRQKYRKYRPKVSVKENPRAWWKYAINAVLEEIRERrRKWSWDYIKKRRDDRKEY 228

                   ....
gi 1063693952  378 IQLY 381
Cdd:pfam16908  229 IELY 232
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
1-830 3.27e-58

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 225.53  E-value: 3.27e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952    1 MFEAHVLHLLRRYLGEYVHGLSTEALRISVWKGDVVLKDLKLKAEALNSLKLPVAVKSGFVGTITLKVPWKSLGKEPVIV 80
Cdd:COG5043      1 MLEGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952   81 LIDRVFVLAYPAPDDRTLKEEDREKLLETKLQQIEEAETATLEARAKSKLGSPPQGNSWLGSIIATIIGNLKVSISNVHI 160
Cdd:COG5043     81 YIEDIYLLISPQAKNSLTREELPQSQQALKQRQLDSWEILRETLEESSSSPNISRKQSFIESLITKLIDNIQIYIEDIHL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  161 RYEDSTSN--PGhPFAAGITLAKLAAVTMDEEGNETF--DTSGALDKLrksLQLERLALYhdsnsfPWEIEKQWDNITPE 236
Cdd:COG5043    161 RFEDNLSAdlEG-PYSFGLTLYSLRATSTDASWTEYFvsTDSSCIHKL---ITLDYFSIY------WCEISPCITTEDID 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  237 EWIEMFEDGIKEqtehKIKSKwalnRHYLLSPINGSLKyhrLGNQERNNPEIPFERASVILNDVNVTITEEQYHD----- 311
Cdd:COG5043    231 SYLENFQPMIAE----KSPAY----NEYILKPVRGTAK---VSINKLPTDEIPRLRGQLSVEEFSISLSDHMYYSllgvl 299
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  312 -WIKLVEVVSRYKTYIEIShlrpmvPVSEAPRLWWRFAAQASL---QQKRlcYRFSWDSIHHLCQLRRRYIQLYANFL-- 385
Cdd:COG5043    300 dYLQVVMKQQKFLKYRPKS------TPKEKPLEWFKYIILVVLdsiHEKR--YHWTWKYFKERCEDRRAYMKIIRKKYln 371
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  386 -QQSSDVNYP-EMREIEKDLDSKVILLWRLLAhakvesvksKEAAEQRKL----KKGGWFSFNW--RTEAEDDpevDSVA 457
Cdd:COG5043    372 eQLSADLSKElEKRELTYDLIKYRSRLFRSLA---------KRRNSIYLKpqthKLQGWFSGLWngKPQAQDE---DTLA 439
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  458 GGSKlmeerlTKDEWKAI---NKLLSHQPdeemnlySGKDMQNMTHFLVTVSIGQGAARIVDINQTEVLcGRFEQLDVTT 534
Cdd:COG5043    440 STDK------TAAELTDQeqkDFFSEIEP-------VGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINL-ISQRFENFKS 505
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  535 KFrhrstqcdvSLRFYGLS--APEGSLaQSVSSERKTNALMASFVNAPIGENIDWRLSATISP------------CHATI 600
Cdd:COG5043    506 KF---------SLNKLDLFdgATNPEL-KPYRSIRNKPKVRESESLQEIEEESRTHLFASFEDskpdgkasstliIHLRT 575
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  601 WTESYDRVLEFVKRSNAVSPTVALETAAVL----QMKLEEVTRRAQEQLQIVLEEQSRFALDIDIDAPKVRIPLRASGSS 676
Cdd:COG5043    576 LVIFYNRVCILSVLKFFVPSRTKIEHVSEWvysaAATVMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPEDCTDPK 655
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  677 kcSSHFLLDFGNFTLTT--MDTRSEEQRQNL-------YSRFCISGRDIAAFftdCGSDNQGcslVMEdftnqpilspiL 747
Cdd:COG5043    656 --SPTLFLDAGRISIHSqlVEDAIIKKFRELqtlenlmYDRFTISLFNVRCL---IGPDYEG---KRE-----------L 716
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  748 EKADNVYSLIDRCGMAVIVDQIKVPH-PSYPSTRISIQVPNIGVHFSPTRYMRIMQLfdilygAMKTYSQAPVDHMPDGI 826
Cdd:COG5043    717 PKGKCDYHILKELKLEINVEISILPKaTNLPKIKVSGHMPHASLMFSDVQYKVIINL------MSNILPTISVDEINGDY 790

                   ....
gi 1063693952  827 QPWS 830
Cdd:COG5043    791 QQFS 794
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
576-808 2.36e-47

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 171.16  E-value: 2.36e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  576 FVNAPIGENIDWRLSATISPCHATIWTESYDRVLEFVKRSNAVSPTV-ALETAAvlQMKLEEVTRRAQEQLQIVLEEQSR 654
Cdd:pfam16910    1 FETNPLDGSADSRLTVKLRPLEIIYDPHFIEEVIDFFKPPESHLELIgALMAAA--EATLEGIKEQTRAGLEYALEEHKT 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  655 FALDIDIDAPKVRIPLraSGSSKCSSHFLLDFGNFTLTTM-------------------DTRSEEQRQNLYSRFCISGRD 715
Cdd:pfam16910   79 LDLDIDLQAPLIIVPE--DYTSKDSPCLILDAGHISVTSDlvdkstikeikskqsqqytEEDLKELESLMYDKFSLKLSD 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  716 IAAFFTDCGSDNQGCslvmedftnqpilspILEKADNVYSLIDRCGMAVIVDQIKVPH-PSYPSTRISIQVPNIGVHFSP 794
Cdd:pfam16910  157 TQVLIGPSGEDWKEA---------------LTEDDSSPLHILEPINLDLTLEKSILPKaPRLPKFKVSGHLPSLHINFSD 221
                          250
                   ....*....|....
gi 1063693952  795 TRYMRIMQLFDILY 808
Cdd:pfam16910  222 DKYKSLMRLIDVSI 235
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3542-4006 6.22e-26

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 118.83  E-value: 6.22e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3542 SHLLASEDSEFHVIVELAELGISVIDHAPEEILYMSVQNLFVAYSTGlgSGLSRFKLRMQGIQVDNQLPLAPMPVLFRP- 3620
Cdd:COG5043   1984 MKLDSGADLEVKGVLLLKGVGISLIDRKDQELAYMTNVGIGLRFIDS--KAYQTFSWECAWVQIDNQLVLGIYPVILYPt 2061
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3621 ----QRTGDKADYIL--KFSVTLQSNAGLDLRVYPYIDFQG---RENTAFLINIHEPI-----IW----RIHEMIQQANL 3682
Cdd:COG5043   2062 eisqEEKEIENHLLPsrKFAVVKDSDSAVTYDKYVTILLQElsiELDEDLALAYLEKLkfpgsKYmddkKFDDEIELPDI 2141
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3683 srlsDPNSTAVSVdpFIQIgvLNFSEVRFRVSMA----MSPSQRPRGVLGFWSS-----LMTALGNTENMPVRISERFHE 3753
Cdd:COG5043   2142 ----IINKSGSNI--YFEF--LHLQPTRLHISFSrsseSSGEDGKVVPSSNSYSdfygmLAMTLGNINDAPVRLNSLLMD 2213
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3754 NISMRQSTMIN--------NAIRNVKK-----DLLGQPLQLL----SGV-----------------------------DI 3787
Cdd:COG5043   2214 NARVSLPELFDliashylqQVEYQIYKilgsaDFLGNPVGLFetvsSGVsdlfyepyqgrflvdnsqewgigiakggnSF 2293
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3788 LGNA--------SSALGHMSQGIAALSMDKKFIQSR--QRQENKGVEDFgDIIREGGGALAKGLFRGVTGILTKPLEGAK 3857
Cdd:COG5043   2294 IKKTiygvsdsvSKFTGSISKGLSLVTSDPELQSSRrlVRRRNRPKGSV-YGVTAGATSLYDSTSSGEKGLALEPIIGAA 2372
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3858 SSGVEGFVSGFGKGIIGAAAQPVSGVLDLLSKTTEGAnamrmKIAAAITSDEQLLRRRLPRAVGADSLLRPYNDYRAQGQ 3937
Cdd:COG5043   2373 TNGASGFVKGLGKGILGLETKPLVGFLDLTSNDSEGI-----KNTTTVLDYHDIPRLRLPRYVWDDGCVAPYDLRESQGQ 2447
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063693952 3938 VILQlaesgSFLGqvdlfkvrGKFALtDAYESHFILPKGKVLMITHRRVILLQQPSNIMgqrKFIPAKD 4006
Cdd:COG5043   2448 YWLK-----TLDA--------GKYPL-DEYKFHDIINNVAVIISRDIHAIVTSKILILK---DYIPSKA 2499
Vps62 pfam06101
Vacuolar protein sorting-associated protein 62; Vps62 is a vacuolar protein sorting (VPS) ...
2013-2171 8.32e-08

Vacuolar protein sorting-associated protein 62; Vps62 is a vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins.


Pssm-ID: 461828  Cd Length: 539  Bit Score: 58.40  E-value: 8.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 2013 IPLASCTNFDRIWvSPKENGPRNN-LTIWRPQA-PSNYVILG------------------DCVTSRAIPPTqavmavsnt 2072
Cdd:pfam06101   29 LEVAQISTFEKVW-STYEGGPDNKgATFYEPSGiPEGFFCLGhycqpnnqplfgwvlvarDVSASKPEGPA--------- 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 2073 ygrVRKPIGFNRIGLFsviqglegdnvqHSHNSNECS---LWMPVAPVGYTAMGCVANIGSEQPPDHIVYCLRSDLVSSS 2149
Cdd:pfam06101   99 ---LKKPLDYTLVWSS------------NSLKIKQDGcgyFWLPVPPEGYKAVGHVVTTSPEKPSLDEVRCVRADLTDQC 163
                          170       180
                   ....*....|....*....|..
gi 1063693952 2150 SFSECIYTVPSSSLfESGFSIW 2171
Cdd:pfam06101  164 ETDRLIWGTGSKSP-KNGFNVW 184
C2 cd00030
C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed ...
2648-2754 3.59e-06

C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


Pssm-ID: 175973 [Multi-domain]  Cd Length: 102  Bit Score: 48.22  E-value: 3.59e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 2648 MTVQILEAKGLHIIDDGNSHSFFCTLRLVVDsqgaepqklfpQSARTKCVKPSTTIVndlmectskWNELFIFEIPRKGV 2727
Cdd:cd00030      1 LRVTVIEARNLPAKDLNGKSDPYVKVSLGGK-----------QKFKTKVVKNTLNPV---------WNETFEFPVLDPES 60
                           90       100
                   ....*....|....*....|....*..
gi 1063693952 2728 ARLEVEVTNlAAKAGKGEVVGSLSFPV 2754
Cdd:cd00030     61 DTLTVEVWD-KDRFSKDDFLGEVEIPL 86
Vps62 pfam06101
Vacuolar protein sorting-associated protein 62; Vps62 is a vacuolar protein sorting (VPS) ...
2251-2370 3.86e-06

Vacuolar protein sorting-associated protein 62; Vps62 is a vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins.


Pssm-ID: 461828  Cd Length: 539  Bit Score: 53.00  E-value: 3.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 2251 VSTpnFERIW-WDKGGDLRRPVSIWRPVPRP-GFAILG------------------DSITEGLEPPALgilfkaddseia 2310
Cdd:pfam06101   34 IST--FEKVWsTYEGGPDNKGATFYEPSGIPeGFFCLGhycqpnnqplfgwvlvarDVSASKPEGPAL------------ 99
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063693952 2311 AKPVQFNKV---AHIVGKGFDEVFCWFPVAPPGYVSLGCVLSKFDEAPHVDSFCCPRIDLVNQ 2370
Cdd:pfam06101  100 KKPLDYTLVwssNSLKIKQDGCGYFWLPVPPEGYKAVGHVVTTSPEKPSLDEVRCVRADLTDQ 162
SHR-BD pfam06650
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
3145-3452 1.33e-05

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 50.00  E-value: 1.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3145 TIRFFVPYWITNDSYLPLSYRvveiepsenveagspcltraSKSFKKNPVFSMERRHQKKNVrvlesiedtspMPSMLS- 3223
Cdd:pfam06650    2 KVSIYSPYVILNKTGLPLIVR--------------------SKGNKNKAAGTLESHEGGRRL-----------IPLMFSf 50
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3224 PQESAGRSGVVLfpSQKDSYVSPRIGI-------AVAARDSDSYSP---GISLLELEKKeridvkafckdasyYMLsavl 3293
Cdd:pfam06650   51 DTFDDRKNRALL--RIGDSSWSKPFSFdaigqtnDVVLPSPNGQNEvylGISVSEGRGK--------------YKL---- 110
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3294 nmtsdrTKVIHLQPHTLFINRVGVSICLQQCDCQTEEWINPSDpPKLFGWQSSTRLELLKLRVKG--YRWSTPFSVFSEG 3371
Cdd:pfam06650  111 ------TKIVTIAPRFIIKNKLPEDLEIREPGSSKIISLPPGE-LIPLHWLRNVEEKQLCIRFPGsnSQWSSPFNISDVG 183
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3372 TMRVPVPKEDGTDQLqLRVQVRSgtKNSRYEVIFRPNSISGPYRIENRS--------------------MFLPIRYRqve 3431
Cdd:pfam06650  184 STYVKVRRQNSGQKL-LKVEIIL--EDATIFIRIEDEDNNWPFSIRNFSdvefifyqrnpnlnsdgennEYKPIYYR--- 257
                          330       340
                   ....*....|....*....|.
gi 1063693952 3432 gvseswqfLPPNAAASFYWEN 3452
Cdd:pfam06650  258 --------LPPKSVMPYAWDY 270
C2 smart00239
Protein kinase C conserved region 2 (CalB); Ca2+-binding motif present in phospholipases, ...
2647-2754 1.53e-05

Protein kinase C conserved region 2 (CalB); Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotagmins (among others). Some do not appear to contain Ca2+-binding sites. Particular C2s appear to bind phospholipids, inositol polyphosphates, and intracellular proteins. Unusual occurrence in perforin. Synaptotagmin and PLC C2s are permuted in sequence with respect to N- and C-terminal beta strands. SMART detects C2 domains using one or both of two profiles.


Pssm-ID: 214577 [Multi-domain]  Cd Length: 101  Bit Score: 46.33  E-value: 1.53e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  2647 YMTVQILEAKGLHIIDDGNSHSFFCTLRLVVDSQgaepqklfpQSARTKCVKPSTTIVndlmectskWNELFIFEIPRKG 2726
Cdd:smart00239    1 TLTVKIISARNLPPKDKGGKSDPYVKVSLDGDPK---------EKKKTKVVKNTLNPV---------WNETFEFEVPPPE 62
                            90       100
                    ....*....|....*....|....*...
gi 1063693952  2727 VARLEVEVTNlAAKAGKGEVVGSLSFPV 2754
Cdd:smart00239   63 LAELEIEVYD-KDRFGRDDFIGQVTIPL 89
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
3701-3913 2.03e-05

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 47.92  E-value: 2.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3701 IGVLNFSEVRFRVSMAMSP------SQRPRGVLGFW-SSLMTALGNTENMPVRISERFHENISMRQSTMINNAIRNVKKD 3773
Cdd:pfam16909    4 FELLHLQPIKLHLSFSRSErvnleeSLEKSNPLSFLlNSLGMTLGNIDDAPIKLNALELENVFVTLPQLQNRIQKHYSQQ 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3774 LLGQPLQLLSGVDILGNASSALGHMSQGiaalsmdkkfiqsrqrqenkgvedFGDIIREgggalakglfrgvtgiltkPL 3853
Cdd:pfam16909   84 FLYQLYKILGSLDFLGNPVGLFNNISSG------------------------VKDFFYE-------------------PY 120
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3854 EGAkSSGVEGFVSGFGKGIIGAAAQPVSGVLDLLSKTTEGAnamrMKIAAAITSDEQLLR 3913
Cdd:pfam16909  121 QGL-IQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSKITGSI----GKGLAALTMDKQYQQ 175
C2 pfam00168
C2 domain;
2646-2734 2.86e-03

C2 domain;


Pssm-ID: 425499 [Multi-domain]  Cd Length: 104  Bit Score: 39.99  E-value: 2.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 2646 NYMTVQILEAKGLHIIDDGNSHSFFCTLRLVVDSQgaepqklfpqSARTKCVKpsttivNDLmecTSKWNELFIFEIPRK 2725
Cdd:pfam00168    1 GRLTVTVIEAKNLPPKDGNGTSDPYVKVYLLDGKQ----------KKKTKVVK------NTL---NPVWNETFTFSVPDP 61

                   ....*....
gi 1063693952 2726 GVARLEVEV 2734
Cdd:pfam00168   62 ENAVLEIEV 70
 
Name Accession Description Interval E-value
VPS13 pfam16908
Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar ...
139-381 2.33e-82

Vacuolar sorting-associated protein 13, N-terminal; VPS13 is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies just downstream from Chorein_N family, pfam12624. The exact function of this domain is not known.


Pssm-ID: 465309  Cd Length: 234  Bit Score: 271.44  E-value: 2.33e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  139 WLGSIIATIIGNLKVSISNVHIRYEDSTSNPGHPFAAGITLAKLAAVTMDEEGNETFDTSGAlDKLRKSLQLERLALYHD 218
Cdd:pfam16908    1 FTESLITKIIDNLQVTIKNIHIRYEDSVSNPGHPFAFGITLEELSAQSTDENWKPTFIQGTS-KIIHKLVELESLSVYWD 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  219 SNSfpwEIEKQWDNITPEEWIEMFEDGIKEQTEHKIkskwalNRHYLLSPINGSLKYHRlgNQERNNPEIPFERASVILN 298
Cdd:pfam16908   80 TDS---ESLELLGDLDLEELLEKFKSLIASKSNKPP------DHQYILKPVSGSAKLTL--NKKGETETIPKIDLDLEFD 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  299 DVNVTITEEQYHDWIKLVEVVSRYKTYIEISHLRPMVPVSEAPRLWWRFAAQASLQQKRLC-YRFSWDSIHHLCQLRRRY 377
Cdd:pfam16908  149 EIGLTLDDRQYRDILSLLDSFHRFLRRQKYRKYRPKVSVKENPRAWWKYAINAVLEEIRERrRKWSWDYIKKRRDDRKEY 228

                   ....
gi 1063693952  378 IQLY 381
Cdd:pfam16908  229 IELY 232
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
1-830 3.27e-58

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 225.53  E-value: 3.27e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952    1 MFEAHVLHLLRRYLGEYVHGLSTEALRISVWKGDVVLKDLKLKAEALNSLKLPVAVKSGFVGTITLKVPWKSLGKEPVIV 80
Cdd:COG5043      1 MLEGLLANLLNRLLGSYVENFDTKQLNVGVWGGDVSLHNLRIKPSALDKLGLPIEVTSGLIGTLTLEIPWSSLKNKPVEI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952   81 LIDRVFVLAYPAPDDRTLKEEDREKLLETKLQQIEEAETATLEARAKSKLGSPPQGNSWLGSIIATIIGNLKVSISNVHI 160
Cdd:COG5043     81 YIEDIYLLISPQAKNSLTREELPQSQQALKQRQLDSWEILRETLEESSSSPNISRKQSFIESLITKLIDNIQIYIEDIHL 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  161 RYEDSTSN--PGhPFAAGITLAKLAAVTMDEEGNETF--DTSGALDKLrksLQLERLALYhdsnsfPWEIEKQWDNITPE 236
Cdd:COG5043    161 RFEDNLSAdlEG-PYSFGLTLYSLRATSTDASWTEYFvsTDSSCIHKL---ITLDYFSIY------WCEISPCITTEDID 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  237 EWIEMFEDGIKEqtehKIKSKwalnRHYLLSPINGSLKyhrLGNQERNNPEIPFERASVILNDVNVTITEEQYHD----- 311
Cdd:COG5043    231 SYLENFQPMIAE----KSPAY----NEYILKPVRGTAK---VSINKLPTDEIPRLRGQLSVEEFSISLSDHMYYSllgvl 299
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  312 -WIKLVEVVSRYKTYIEIShlrpmvPVSEAPRLWWRFAAQASL---QQKRlcYRFSWDSIHHLCQLRRRYIQLYANFL-- 385
Cdd:COG5043    300 dYLQVVMKQQKFLKYRPKS------TPKEKPLEWFKYIILVVLdsiHEKR--YHWTWKYFKERCEDRRAYMKIIRKKYln 371
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  386 -QQSSDVNYP-EMREIEKDLDSKVILLWRLLAhakvesvksKEAAEQRKL----KKGGWFSFNW--RTEAEDDpevDSVA 457
Cdd:COG5043    372 eQLSADLSKElEKRELTYDLIKYRSRLFRSLA---------KRRNSIYLKpqthKLQGWFSGLWngKPQAQDE---DTLA 439
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  458 GGSKlmeerlTKDEWKAI---NKLLSHQPdeemnlySGKDMQNMTHFLVTVSIGQGAARIVDINQTEVLcGRFEQLDVTT 534
Cdd:COG5043    440 STDK------TAAELTDQeqkDFFSEIEP-------VGQLYSDTVNLDVEVSIAKGSFVIQKHIRKINL-ISQRFENFKS 505
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  535 KFrhrstqcdvSLRFYGLS--APEGSLaQSVSSERKTNALMASFVNAPIGENIDWRLSATISP------------CHATI 600
Cdd:COG5043    506 KF---------SLNKLDLFdgATNPEL-KPYRSIRNKPKVRESESLQEIEEESRTHLFASFEDskpdgkasstliIHLRT 575
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  601 WTESYDRVLEFVKRSNAVSPTVALETAAVL----QMKLEEVTRRAQEQLQIVLEEQSRFALDIDIDAPKVRIPLRASGSS 676
Cdd:COG5043    576 LVIFYNRVCILSVLKFFVPSRTKIEHVSEWvysaAATVMTLTRQTRASLDSALEMHKTSNVTIDLQAPLIVFPEDCTDPK 655
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  677 kcSSHFLLDFGNFTLTT--MDTRSEEQRQNL-------YSRFCISGRDIAAFftdCGSDNQGcslVMEdftnqpilspiL 747
Cdd:COG5043    656 --SPTLFLDAGRISIHSqlVEDAIIKKFRELqtlenlmYDRFTISLFNVRCL---IGPDYEG---KRE-----------L 716
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  748 EKADNVYSLIDRCGMAVIVDQIKVPH-PSYPSTRISIQVPNIGVHFSPTRYMRIMQLfdilygAMKTYSQAPVDHMPDGI 826
Cdd:COG5043    717 PKGKCDYHILKELKLEINVEISILPKaTNLPKIKVSGHMPHASLMFSDVQYKVIINL------MSNILPTISVDEINGDY 790

                   ....
gi 1063693952  827 QPWS 830
Cdd:COG5043    791 QQFS 794
VPS13_mid_rpt pfam16910
Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic ...
576-808 2.36e-47

Repeating coiled region of VPS13; This repeat is a family of repeating regions of eukaryotic vacuolar sorting-associated 13 proteins. This repeating region shares a common core element that includes a well-conserved P-x4-P-x13-17-G sequence. The exact function of this repeat is not known.


Pssm-ID: 465311 [Multi-domain]  Cd Length: 236  Bit Score: 171.16  E-value: 2.36e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  576 FVNAPIGENIDWRLSATISPCHATIWTESYDRVLEFVKRSNAVSPTV-ALETAAvlQMKLEEVTRRAQEQLQIVLEEQSR 654
Cdd:pfam16910    1 FETNPLDGSADSRLTVKLRPLEIIYDPHFIEEVIDFFKPPESHLELIgALMAAA--EATLEGIKEQTRAGLEYALEEHKT 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  655 FALDIDIDAPKVRIPLraSGSSKCSSHFLLDFGNFTLTTM-------------------DTRSEEQRQNLYSRFCISGRD 715
Cdd:pfam16910   79 LDLDIDLQAPLIIVPE--DYTSKDSPCLILDAGHISVTSDlvdkstikeikskqsqqytEEDLKELESLMYDKFSLKLSD 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  716 IAAFFTDCGSDNQGCslvmedftnqpilspILEKADNVYSLIDRCGMAVIVDQIKVPH-PSYPSTRISIQVPNIGVHFSP 794
Cdd:pfam16910  157 TQVLIGPSGEDWKEA---------------LTEDDSSPLHILEPINLDLTLEKSILPKaPRLPKFKVSGHLPSLHINFSD 221
                          250
                   ....*....|....
gi 1063693952  795 TRYMRIMQLFDILY 808
Cdd:pfam16910  222 DKYKSLMRLIDVSI 235
Chorein_N pfam12624
N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein ...
2-116 7.30e-40

N-terminal region of Chorein or VPS13; Although mutations in the full-length vacuolar protein sorting 13A (VPS13A) protein in vertebrates lead to the disease of chorea-acanthocytosis, the exact function of any of the regions within the protein is not yet known. This region is the proposed leucine zipper at the N-terminus. The full-length protein is a transmembrane protein with a presumed role in vesicle-mediated sorting and intracellular protein transport.


Pssm-ID: 463646  Cd Length: 116  Bit Score: 145.02  E-value: 7.30e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952    2 FEAHVLHLLRRYLGEYVHGLSTEALRISVWKGDVVLKDLKLKAEALNSLKLPVAVKSGFVGTITLKVPWKSLGKEPVIVL 81
Cdd:pfam12624    1 LESLVASLLNRYLGEYVENLDPDQLKVGLWSGDVVLENLKLKKEALDKLDLPIEVKSGHIGKLTLKIPWTNLKSEPVVIE 80
                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1063693952   82 IDRVFVLAYPAPDDRTL-KEEDREKLLETKLQQIEE 116
Cdd:pfam12624   81 IEDVYLLAVPKDESEEYdEEEEEKRELAAKKEKLAA 116
MRS6 COG5043
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
3542-4006 6.22e-26

Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];


Pssm-ID: 227376 [Multi-domain]  Cd Length: 2552  Bit Score: 118.83  E-value: 6.22e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3542 SHLLASEDSEFHVIVELAELGISVIDHAPEEILYMSVQNLFVAYSTGlgSGLSRFKLRMQGIQVDNQLPLAPMPVLFRP- 3620
Cdd:COG5043   1984 MKLDSGADLEVKGVLLLKGVGISLIDRKDQELAYMTNVGIGLRFIDS--KAYQTFSWECAWVQIDNQLVLGIYPVILYPt 2061
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3621 ----QRTGDKADYIL--KFSVTLQSNAGLDLRVYPYIDFQG---RENTAFLINIHEPI-----IW----RIHEMIQQANL 3682
Cdd:COG5043   2062 eisqEEKEIENHLLPsrKFAVVKDSDSAVTYDKYVTILLQElsiELDEDLALAYLEKLkfpgsKYmddkKFDDEIELPDI 2141
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3683 srlsDPNSTAVSVdpFIQIgvLNFSEVRFRVSMA----MSPSQRPRGVLGFWSS-----LMTALGNTENMPVRISERFHE 3753
Cdd:COG5043   2142 ----IINKSGSNI--YFEF--LHLQPTRLHISFSrsseSSGEDGKVVPSSNSYSdfygmLAMTLGNINDAPVRLNSLLMD 2213
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3754 NISMRQSTMIN--------NAIRNVKK-----DLLGQPLQLL----SGV-----------------------------DI 3787
Cdd:COG5043   2214 NARVSLPELFDliashylqQVEYQIYKilgsaDFLGNPVGLFetvsSGVsdlfyepyqgrflvdnsqewgigiakggnSF 2293
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3788 LGNA--------SSALGHMSQGIAALSMDKKFIQSR--QRQENKGVEDFgDIIREGGGALAKGLFRGVTGILTKPLEGAK 3857
Cdd:COG5043   2294 IKKTiygvsdsvSKFTGSISKGLSLVTSDPELQSSRrlVRRRNRPKGSV-YGVTAGATSLYDSTSSGEKGLALEPIIGAA 2372
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3858 SSGVEGFVSGFGKGIIGAAAQPVSGVLDLLSKTTEGAnamrmKIAAAITSDEQLLRRRLPRAVGADSLLRPYNDYRAQGQ 3937
Cdd:COG5043   2373 TNGASGFVKGLGKGILGLETKPLVGFLDLTSNDSEGI-----KNTTTVLDYHDIPRLRLPRYVWDDGCVAPYDLRESQGQ 2447
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063693952 3938 VILQlaesgSFLGqvdlfkvrGKFALtDAYESHFILPKGKVLMITHRRVILLQQPSNIMgqrKFIPAKD 4006
Cdd:COG5043   2448 YWLK-----TLDA--------GKYPL-DEYKFHDIINNVAVIISRDIHAIVTSKILILK---DYIPSKA 2499
Vps62 pfam06101
Vacuolar protein sorting-associated protein 62; Vps62 is a vacuolar protein sorting (VPS) ...
2013-2171 8.32e-08

Vacuolar protein sorting-associated protein 62; Vps62 is a vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins.


Pssm-ID: 461828  Cd Length: 539  Bit Score: 58.40  E-value: 8.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 2013 IPLASCTNFDRIWvSPKENGPRNN-LTIWRPQA-PSNYVILG------------------DCVTSRAIPPTqavmavsnt 2072
Cdd:pfam06101   29 LEVAQISTFEKVW-STYEGGPDNKgATFYEPSGiPEGFFCLGhycqpnnqplfgwvlvarDVSASKPEGPA--------- 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 2073 ygrVRKPIGFNRIGLFsviqglegdnvqHSHNSNECS---LWMPVAPVGYTAMGCVANIGSEQPPDHIVYCLRSDLVSSS 2149
Cdd:pfam06101   99 ---LKKPLDYTLVWSS------------NSLKIKQDGcgyFWLPVPPEGYKAVGHVVTTSPEKPSLDEVRCVRADLTDQC 163
                          170       180
                   ....*....|....*....|..
gi 1063693952 2150 SFSECIYTVPSSSLfESGFSIW 2171
Cdd:pfam06101  164 ETDRLIWGTGSKSP-KNGFNVW 184
C2 cd00030
C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed ...
2648-2754 3.59e-06

C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


Pssm-ID: 175973 [Multi-domain]  Cd Length: 102  Bit Score: 48.22  E-value: 3.59e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 2648 MTVQILEAKGLHIIDDGNSHSFFCTLRLVVDsqgaepqklfpQSARTKCVKPSTTIVndlmectskWNELFIFEIPRKGV 2727
Cdd:cd00030      1 LRVTVIEARNLPAKDLNGKSDPYVKVSLGGK-----------QKFKTKVVKNTLNPV---------WNETFEFPVLDPES 60
                           90       100
                   ....*....|....*....|....*..
gi 1063693952 2728 ARLEVEVTNlAAKAGKGEVVGSLSFPV 2754
Cdd:cd00030     61 DTLTVEVWD-KDRFSKDDFLGEVEIPL 86
Vps62 pfam06101
Vacuolar protein sorting-associated protein 62; Vps62 is a vacuolar protein sorting (VPS) ...
2251-2370 3.86e-06

Vacuolar protein sorting-associated protein 62; Vps62 is a vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins.


Pssm-ID: 461828  Cd Length: 539  Bit Score: 53.00  E-value: 3.86e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 2251 VSTpnFERIW-WDKGGDLRRPVSIWRPVPRP-GFAILG------------------DSITEGLEPPALgilfkaddseia 2310
Cdd:pfam06101   34 IST--FEKVWsTYEGGPDNKGATFYEPSGIPeGFFCLGhycqpnnqplfgwvlvarDVSASKPEGPAL------------ 99
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063693952 2311 AKPVQFNKV---AHIVGKGFDEVFCWFPVAPPGYVSLGCVLSKFDEAPHVDSFCCPRIDLVNQ 2370
Cdd:pfam06101  100 KKPLDYTLVwssNSLKIKQDGCGYFWLPVPPEGYKAVGHVVTTSPEKPSLDEVRCVRADLTDQ 162
SHR-BD pfam06650
SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic ...
3145-3452 1.33e-05

SHR-binding domain of vacuolar-sorting associated protein 13; SHR-BD is a family of eukaryotic proteins found on vacuolar-sorting associated proteins towards the C-terminus. In plants, the domain is found to be the region which interacts with SHR or the SHORT-ROOT transcription factor, a regulator of root-growth and asymmetric cell division that separates ground tissue into endodermis and cortex. The plant protein containing the SHR-BD is named SHRUBBY or SHBY, UniProtKB:Q9FT44.


Pssm-ID: 461974 [Multi-domain]  Cd Length: 275  Bit Score: 50.00  E-value: 1.33e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3145 TIRFFVPYWITNDSYLPLSYRvveiepsenveagspcltraSKSFKKNPVFSMERRHQKKNVrvlesiedtspMPSMLS- 3223
Cdd:pfam06650    2 KVSIYSPYVILNKTGLPLIVR--------------------SKGNKNKAAGTLESHEGGRRL-----------IPLMFSf 50
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3224 PQESAGRSGVVLfpSQKDSYVSPRIGI-------AVAARDSDSYSP---GISLLELEKKeridvkafckdasyYMLsavl 3293
Cdd:pfam06650   51 DTFDDRKNRALL--RIGDSSWSKPFSFdaigqtnDVVLPSPNGQNEvylGISVSEGRGK--------------YKL---- 110
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3294 nmtsdrTKVIHLQPHTLFINRVGVSICLQQCDCQTEEWINPSDpPKLFGWQSSTRLELLKLRVKG--YRWSTPFSVFSEG 3371
Cdd:pfam06650  111 ------TKIVTIAPRFIIKNKLPEDLEIREPGSSKIISLPPGE-LIPLHWLRNVEEKQLCIRFPGsnSQWSSPFNISDVG 183
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3372 TMRVPVPKEDGTDQLqLRVQVRSgtKNSRYEVIFRPNSISGPYRIENRS--------------------MFLPIRYRqve 3431
Cdd:pfam06650  184 STYVKVRRQNSGQKL-LKVEIIL--EDATIFIRIEDEDNNWPFSIRNFSdvefifyqrnpnlnsdgennEYKPIYYR--- 257
                          330       340
                   ....*....|....*....|.
gi 1063693952 3432 gvseswqfLPPNAAASFYWEN 3452
Cdd:pfam06650  258 --------LPPKSVMPYAWDY 270
C2 smart00239
Protein kinase C conserved region 2 (CalB); Ca2+-binding motif present in phospholipases, ...
2647-2754 1.53e-05

Protein kinase C conserved region 2 (CalB); Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotagmins (among others). Some do not appear to contain Ca2+-binding sites. Particular C2s appear to bind phospholipids, inositol polyphosphates, and intracellular proteins. Unusual occurrence in perforin. Synaptotagmin and PLC C2s are permuted in sequence with respect to N- and C-terminal beta strands. SMART detects C2 domains using one or both of two profiles.


Pssm-ID: 214577 [Multi-domain]  Cd Length: 101  Bit Score: 46.33  E-value: 1.53e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952  2647 YMTVQILEAKGLHIIDDGNSHSFFCTLRLVVDSQgaepqklfpQSARTKCVKPSTTIVndlmectskWNELFIFEIPRKG 2726
Cdd:smart00239    1 TLTVKIISARNLPPKDKGGKSDPYVKVSLDGDPK---------EKKKTKVVKNTLNPV---------WNETFEFEVPPPE 62
                            90       100
                    ....*....|....*....|....*...
gi 1063693952  2727 VARLEVEVTNlAAKAGKGEVVGSLSFPV 2754
Cdd:smart00239   63 LAELEIEVYD-KDRFGRDDFIGQVTIPL 89
VPS13_C pfam16909
Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar ...
3701-3913 2.03e-05

Vacuolar-sorting-associated 13 protein C-terminal; VPS13_C is a family of eukaryotic vacuolar sorting-associated 13 proteins that lies at the C-terminus of the members, The exact function of this domain is not known.


Pssm-ID: 465310 [Multi-domain]  Cd Length: 175  Bit Score: 47.92  E-value: 2.03e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3701 IGVLNFSEVRFRVSMAMSP------SQRPRGVLGFW-SSLMTALGNTENMPVRISERFHENISMRQSTMINNAIRNVKKD 3773
Cdd:pfam16909    4 FELLHLQPIKLHLSFSRSErvnleeSLEKSNPLSFLlNSLGMTLGNIDDAPIKLNALELENVFVTLPQLQNRIQKHYSQQ 83
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3774 LLGQPLQLLSGVDILGNASSALGHMSQGiaalsmdkkfiqsrqrqenkgvedFGDIIREgggalakglfrgvtgiltkPL 3853
Cdd:pfam16909   84 FLYQLYKILGSLDFLGNPVGLFNNISSG------------------------VKDFFYE-------------------PY 120
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 3854 EGAkSSGVEGFVSGFGKGIIGAAAQPVSGVLDLLSKTTEGAnamrMKIAAAITSDEQLLR 3913
Cdd:pfam16909  121 QGL-IQGPQEFGLGLAKGAKSLVKNTVFGVSDSVSKITGSI----GKGLAALTMDKQYQQ 175
C2B_Synaptotagmin cd00276
C2 domain second repeat present in Synaptotagmin; Synaptotagmin is a membrane-trafficking ...
2649-2735 6.97e-05

C2 domain second repeat present in Synaptotagmin; Synaptotagmin is a membrane-trafficking protein characterized by a N-terminal transmembrane region, a linker, and 2 C-terminal C2 domains. There are several classes of Synaptotagmins. Previously all synaptotagmins were thought to be calcium sensors in the regulation of neurotransmitter release and hormone secretion, but it has been shown that not all of them bind calcium. Of the 17 identified synaptotagmins only 8 bind calcium (1-3, 5-7, 9, 10). The function of the two C2 domains that bind calcium are: regulating the fusion step of synaptic vesicle exocytosis (C2A) and binding to phosphatidyl-inositol-3,4,5-triphosphate (PIP3) in the absence of calcium ions and to phosphatidylinositol bisphosphate (PIP2) in their presence (C2B). C2B also regulates also the recycling step of synaptic vesicles. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the second C2 repeat, C2B, and has a type-I topology.


Pssm-ID: 175975 [Multi-domain]  Cd Length: 134  Bit Score: 45.65  E-value: 6.97e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 2649 TVQILEAKGLHIIDDGNSHSFFCTLRLVVDSqgaepQKLFpqSARTKCVKPSTTIVndlmectskWNELFIFEIPRKGVA 2728
Cdd:cd00276     17 TVVVLKARNLPPSDGKGLSDPYVKVSLLQGG-----KKLK--KKKTSVKKGTLNPV---------FNEAFSFDVPAEQLE 80

                   ....*..
gi 1063693952 2729 RLEVEVT 2735
Cdd:cd00276     81 EVSLVIT 87
C2 pfam00168
C2 domain;
2646-2734 2.86e-03

C2 domain;


Pssm-ID: 425499 [Multi-domain]  Cd Length: 104  Bit Score: 39.99  E-value: 2.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 2646 NYMTVQILEAKGLHIIDDGNSHSFFCTLRLVVDSQgaepqklfpqSARTKCVKpsttivNDLmecTSKWNELFIFEIPRK 2725
Cdd:pfam00168    1 GRLTVTVIEAKNLPPKDGNGTSDPYVKVYLLDGKQ----------KKKTKVVK------NTL---NPVWNETFTFSVPDP 61

                   ....*....
gi 1063693952 2726 GVARLEVEV 2734
Cdd:pfam00168   62 ENAVLEIEV 70
C2A_Munc13-like cd08676
C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins; C2-like domains are ...
2648-2734 3.15e-03

C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins; C2-like domains are thought to be involved in phospholipid binding in a Ca2+ independent manner in both Unc13 and Munc13. Caenorabditis elegans Unc13 has a central domain with sequence similarity to PKC, which includes C1 and C2-related domains. Unc13 binds phorbol esters and DAG with high affinity in a phospholipid manner. Mutations in Unc13 results in abnormal neuronal connections and impairment in cholinergic neurotransmission in the nematode. Munc13 is the mammalian homolog which are expressed in the brain. There are 3 isoforms (Munc13-1, -2, -3) and are thought to play a role in neurotransmitter release and are hypothesized to be high-affinity receptors for phorbol esters. Unc13 and Munc13 contain both C1 and C2 domains. There are two C2 related domains present, one central and one at the carboxyl end. Munc13-1 contains a third C2-like domain. Munc13 interacts with syntaxin, synaptobrevin, and synaptotagmin suggesting a role for these as scaffolding proteins. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the second C2 repeat, C2B, and has a type-II topology.


Pssm-ID: 176058 [Multi-domain]  Cd Length: 153  Bit Score: 41.20  E-value: 3.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063693952 2648 MTVQILEAKGLhIIDDGNSHSF-FCTLRLVVDSQGAEPQKLFPQSARTKCVKPSTTIVNDLMECTS--------KWNELF 2718
Cdd:cd08676     30 LKVTVIEAKGL-LAKDVNGFSDpYCMLGIVPASRERNSEKSKKRKSHRKKAVLKDTVPAKSIKVTEvkpqtlnpVWNETF 108
                           90
                   ....*....|....*.
gi 1063693952 2719 IFEIPRKGVARLEVEV 2734
Cdd:cd08676    109 RFEVEDVSNDQLHLDI 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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