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Conserved domains on  [gi|1063684606|ref|NP_001319037|]
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DNAJ heat shock N-terminal domain-containing protein [Arabidopsis thaliana]

Protein Classification

J domain-containing protein( domain architecture ID 10644999)

J domain-containing protein similar to molecular chaperone DnaJ, a protein that plays crucial roles in protein translation, folding, unfolding, translocation, and degradation, primarily by stimulating the ATPase activity of Hsp70

CATH:  1.10.287.110
Gene Ontology:  GO:0006457
PubMed:  35729039|9644977|8016869|15170475
SCOP:  4000605

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CbpA super family cl34431
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
39-103 1.63e-06

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


The actual alignment was detected with superfamily member COG2214:

Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 46.63  E-value: 1.63e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063684606  39 SFPPSHYDVLGVKMYSSVDDVKDAYQTVASKWDSGSGVSLPAD----FVKIQYAYELLTNLVWKRDYDL 103
Cdd:COG2214     2 PDLKDHYAVLGVPPDASLEEIRQAYRRLAKLLHPDRGGELKALaeelFQRLNEAYEVLSDPERRAEYDR 70
DnaJ super family cl33903
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 43-179 9.06e-05

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG0484:

Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 43.15  E-value: 9.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684606  43 SHYDVLGVKMYSSVDDVKDAYQTVASKW--DSGSGVSLPAD-FVKIQYAYELLTNLVWKRDYDLYAIDESVHIIEELeKQ 119
Cdd:COG0484     1 DYYEILGVSRDASAEEIKKAYRKLAKKYhpDRNPGDPEAEEkFKEINEAYEVLSDPEKRAAYDRFGHAAELLLATEL-AE 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684606 120 YAVEDFAKIKLPLLEVVSYEPEREGFMSITSQDFASKFQDSKPWLIQVYSSGSNSSAQFA 179
Cdd:COG0484    80 SAAAEAAAAEAKEEAAEAGASEYEAIAEEASQLRLASLLLLLALLELALAAVLGLLLALA 139
 
Name Accession Description Interval E-value
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
39-103 1.63e-06

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 46.63  E-value: 1.63e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063684606  39 SFPPSHYDVLGVKMYSSVDDVKDAYQTVASKWDSGSGVSLPAD----FVKIQYAYELLTNLVWKRDYDL 103
Cdd:COG2214     2 PDLKDHYAVLGVPPDASLEEIRQAYRRLAKLLHPDRGGELKALaeelFQRLNEAYEVLSDPERRAEYDR 70
DnaJ smart00271
DnaJ molecular chaperone homology domain;
42-94 4.35e-06

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 44.53  E-value: 4.35e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063684606   42 PSHYDVLGVKMYSSVDDVKDAYQTVASKW--DSGSGVSLPAD--FVKIQYAYELLTN 94
Cdd:smart00271   1 TDYYEILGVPRDASLDEIKKAYRKLALKYhpDKNPGDKEEAEekFKEINEAYEVLSD 57
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 43-102 6.58e-06

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 44.00  E-value: 6.58e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063684606  43 SHYDVLGVKMYSSVDDVKDAYQTVASKW--DSGSGVSLPAD-FVKIQYAYELLTNLVWKRDYD 102
Cdd:pfam00226   1 DYYEILGVSPDASDEEIKKAYRKLALKYhpDKNPGDPEAEEkFKEINEAYEVLSDPEKRAIYD 63
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 43-179 9.06e-05

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 43.15  E-value: 9.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684606  43 SHYDVLGVKMYSSVDDVKDAYQTVASKW--DSGSGVSLPAD-FVKIQYAYELLTNLVWKRDYDLYAIDESVHIIEELeKQ 119
Cdd:COG0484     1 DYYEILGVSRDASAEEIKKAYRKLAKKYhpDRNPGDPEAEEkFKEINEAYEVLSDPEKRAAYDRFGHAAELLLATEL-AE 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684606 120 YAVEDFAKIKLPLLEVVSYEPEREGFMSITSQDFASKFQDSKPWLIQVYSSGSNSSAQFA 179
Cdd:COG0484    80 SAAAEAAAAEAKEEAAEAGASEYEAIAEEASQLRLASLLLLLALLELALAAVLGLLLALA 139
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 44-94 1.70e-04

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 39.84  E-value: 1.70e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063684606  44 HYDVLGVKMYSSVDDVKDAYQTVASKW--DSGSGVSL-PADFVKIQYAYELLTN 94
Cdd:cd06257     2 YYDILGVPPDASDEEIKKAYRKLALKYhpDKNPDDPEaEEKFKEINEAYEVLSD 55
PRK14290 PRK14290
chaperone protein DnaJ; Provisional
 44-102 4.60e-03

chaperone protein DnaJ; Provisional


Pssm-ID: 172778 [Multi-domain]  Cd Length: 365  Bit Score: 39.91  E-value: 4.60e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063684606  44 HYDVLGVKMYSSVDDVKDAYQTVASKW--DSGSGVSLPAD--FVKIQYAYELLTNLVWKRDYD 102
Cdd:PRK14290    5 YYKILGVDRNASQEDIKKAFRELAKKWhpDLHPGNKAEAEekFKEISEAYEVLSDPQKRRQYD 67
 
Name Accession Description Interval E-value
CbpA COG2214
Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];
39-103 1.63e-06

Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription];


Pssm-ID: 441816 [Multi-domain]  Cd Length: 91  Bit Score: 46.63  E-value: 1.63e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063684606  39 SFPPSHYDVLGVKMYSSVDDVKDAYQTVASKWDSGSGVSLPAD----FVKIQYAYELLTNLVWKRDYDL 103
Cdd:COG2214     2 PDLKDHYAVLGVPPDASLEEIRQAYRRLAKLLHPDRGGELKALaeelFQRLNEAYEVLSDPERRAEYDR 70
DnaJ smart00271
DnaJ molecular chaperone homology domain;
42-94 4.35e-06

DnaJ molecular chaperone homology domain;


Pssm-ID: 197617 [Multi-domain]  Cd Length: 60  Bit Score: 44.53  E-value: 4.35e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063684606   42 PSHYDVLGVKMYSSVDDVKDAYQTVASKW--DSGSGVSLPAD--FVKIQYAYELLTN 94
Cdd:smart00271   1 TDYYEILGVPRDASLDEIKKAYRKLALKYhpDKNPGDKEEAEekFKEINEAYEVLSD 57
DnaJ pfam00226
DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is ...
 43-102 6.58e-06

DnaJ domain; DnaJ domains (J-domains) are associated with hsp70 heat-shock system and it is thought that this domain mediates the interaction. DnaJ-domain is therefore part of a chaperone (protein folding) system. The T-antigens, although not in Prosite are confirmed as DnaJ containing domains from literature.


Pssm-ID: 395170 [Multi-domain]  Cd Length: 63  Bit Score: 44.00  E-value: 6.58e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063684606  43 SHYDVLGVKMYSSVDDVKDAYQTVASKW--DSGSGVSLPAD-FVKIQYAYELLTNLVWKRDYD 102
Cdd:pfam00226   1 DYYEILGVSPDASDEEIKKAYRKLALKYhpDKNPGDPEAEEkFKEINEAYEVLSDPEKRAIYD 63
DnaJ COG0484
DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational ...
 43-179 9.06e-05

DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440252 [Multi-domain]  Cd Length: 139  Bit Score: 43.15  E-value: 9.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684606  43 SHYDVLGVKMYSSVDDVKDAYQTVASKW--DSGSGVSLPAD-FVKIQYAYELLTNLVWKRDYDLYAIDESVHIIEELeKQ 119
Cdd:COG0484     1 DYYEILGVSRDASAEEIKKAYRKLAKKYhpDRNPGDPEAEEkFKEINEAYEVLSDPEKRAAYDRFGHAAELLLATEL-AE 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063684606 120 YAVEDFAKIKLPLLEVVSYEPEREGFMSITSQDFASKFQDSKPWLIQVYSSGSNSSAQFA 179
Cdd:COG0484    80 SAAAEAAAAEAKEEAAEAGASEYEAIAEEASQLRLASLLLLLALLELALAAVLGLLLALA 139
DnaJ cd06257
DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and ...
 44-94 1.70e-04

DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, an important chaperonine family. Hsp40 proteins are characterized by the presence of a J domain, which mediates the interaction with Hsp70. They may contain other domains as well, and the architectures provide a means of classification.


Pssm-ID: 99751 [Multi-domain]  Cd Length: 55  Bit Score: 39.84  E-value: 1.70e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063684606  44 HYDVLGVKMYSSVDDVKDAYQTVASKW--DSGSGVSL-PADFVKIQYAYELLTN 94
Cdd:cd06257     2 YYDILGVPPDASDEEIKKAYRKLALKYhpDKNPDDPEaEEKFKEINEAYEVLSD 55
PRK14290 PRK14290
chaperone protein DnaJ; Provisional
 44-102 4.60e-03

chaperone protein DnaJ; Provisional


Pssm-ID: 172778 [Multi-domain]  Cd Length: 365  Bit Score: 39.91  E-value: 4.60e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063684606  44 HYDVLGVKMYSSVDDVKDAYQTVASKW--DSGSGVSLPAD--FVKIQYAYELLTNLVWKRDYD 102
Cdd:PRK14290    5 YYKILGVDRNASQEDIKKAFRELAKKWhpDLHPGNKAEAEekFKEISEAYEVLSDPQKRRQYD 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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