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Conserved domains on  [gi|1063728814|ref|NP_001318876|]
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homolog of X-ray repair cross complementing 2 (XRCC2) [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
XRCC2 cd19490
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells ...
43-305 9.01e-72

XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site.


:

Pssm-ID: 410898 [Multi-domain]  Cd Length: 226  Bit Score: 222.61  E-value: 9.01e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728814  43 GNVVEITGASTSAKTQILIQAAISCILPKTWNGIHYGGLGKLVLFLDLDCRFDVLRLSQMLKHRLLQANWLGNgawwqle 122
Cdd:cd19490     1 GDVIEITGPSGSGKTELLYHLAARCILPSSWGGVPLGGLEAAVVFIDTDGRFDILRLRSILEARIRAAIQAAN------- 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728814 123 esnvkscksaeEKTKTVFDEELYASCMKRFLYVRCYDSLELLSSlkyftvLQTLHYRIQQQeACGSQVGVLMIDSIGAFH 202
Cdd:cd19490    74 -----------SSDDEEDVEEIARECLQRLHIFRCHSSLQLLAT------LLSLENYLLSL-SANPELGLLLIDSISAFY 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728814 203 WTDRLSSSLALEthnrKSLSLTNVVETIVQELKKLLLVHSLVVLATKGTIYEEKYPANENNRkvssndhfSGNVASKAQQ 282
Cdd:cd19490   136 WQDRFSAELARA----APLLQEAALRAILRELRRLRRRFQLVVIATKQALFPGKSASTDNPA--------ANNAVSKASA 203
                         250       260
                  ....*....|....*....|...
gi 1063728814 283 PPFREFMPSSWQAFVTHKIIIRK 305
Cdd:cd19490   204 PSHREYLPRPWQRLVTHRLVLSR 226
 
Name Accession Description Interval E-value
XRCC2 cd19490
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells ...
43-305 9.01e-72

XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site.


Pssm-ID: 410898 [Multi-domain]  Cd Length: 226  Bit Score: 222.61  E-value: 9.01e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728814  43 GNVVEITGASTSAKTQILIQAAISCILPKTWNGIHYGGLGKLVLFLDLDCRFDVLRLSQMLKHRLLQANWLGNgawwqle 122
Cdd:cd19490     1 GDVIEITGPSGSGKTELLYHLAARCILPSSWGGVPLGGLEAAVVFIDTDGRFDILRLRSILEARIRAAIQAAN------- 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728814 123 esnvkscksaeEKTKTVFDEELYASCMKRFLYVRCYDSLELLSSlkyftvLQTLHYRIQQQeACGSQVGVLMIDSIGAFH 202
Cdd:cd19490    74 -----------SSDDEEDVEEIARECLQRLHIFRCHSSLQLLAT------LLSLENYLLSL-SANPELGLLLIDSISAFY 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728814 203 WTDRLSSSLALEthnrKSLSLTNVVETIVQELKKLLLVHSLVVLATKGTIYEEKYPANENNRkvssndhfSGNVASKAQQ 282
Cdd:cd19490   136 WQDRFSAELARA----APLLQEAALRAILRELRRLRRRFQLVVIATKQALFPGKSASTDNPA--------ANNAVSKASA 203
                         250       260
                  ....*....|....*....|...
gi 1063728814 283 PPFREFMPSSWQAFVTHKIIIRK 305
Cdd:cd19490   204 PSHREYLPRPWQRLVTHRLVLSR 226
 
Name Accession Description Interval E-value
XRCC2 cd19490
XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells ...
43-305 9.01e-72

XRCC2 recombinase; XRCC2 (X-ray repair complementing defective repair in Chinese hamster cells 2) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC2, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC3, helps recruit RAD51 to the break site.


Pssm-ID: 410898 [Multi-domain]  Cd Length: 226  Bit Score: 222.61  E-value: 9.01e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728814  43 GNVVEITGASTSAKTQILIQAAISCILPKTWNGIHYGGLGKLVLFLDLDCRFDVLRLSQMLKHRLLQANWLGNgawwqle 122
Cdd:cd19490     1 GDVIEITGPSGSGKTELLYHLAARCILPSSWGGVPLGGLEAAVVFIDTDGRFDILRLRSILEARIRAAIQAAN------- 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728814 123 esnvkscksaeEKTKTVFDEELYASCMKRFLYVRCYDSLELLSSlkyftvLQTLHYRIQQQeACGSQVGVLMIDSIGAFH 202
Cdd:cd19490    74 -----------SSDDEEDVEEIARECLQRLHIFRCHSSLQLLAT------LLSLENYLLSL-SANPELGLLLIDSISAFY 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728814 203 WTDRLSSSLALEthnrKSLSLTNVVETIVQELKKLLLVHSLVVLATKGTIYEEKYPANENNRkvssndhfSGNVASKAQQ 282
Cdd:cd19490   136 WQDRFSAELARA----APLLQEAALRAILRELRRLRRRFQLVVIATKQALFPGKSASTDNPA--------ANNAVSKASA 203
                         250       260
                  ....*....|....*....|...
gi 1063728814 283 PPFREFMPSSWQAFVTHKIIIRK 305
Cdd:cd19490   204 PSHREYLPRPWQRLVTHRLVLSR 226
RecA-like cd01393
RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA ...
43-208 6.30e-11

RecA family; RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange. While prokaryotes have a single RecA protein, eukaryotes have multiple RecA homologs such as Rad51, DMC1 and Rad55/57. Archaea have the RecA-like homologs RadA and RadB.


Pssm-ID: 410881 [Multi-domain]  Cd Length: 185  Bit Score: 60.83  E-value: 6.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728814  43 GNVVEITGASTSAKTQILIQAAISCILpktwngihyggLGKLVLFLDLDCRFDVLRLSQMLKHRllqanwlgngawwqle 122
Cdd:cd01393     1 GKITEIYGPPGSGKTQLALQLAANALL-----------LGGGVVWIDTEGAFPPSRLVQILEAS---------------- 53
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728814 123 esnvkscKSAEEKTKTVFDeelyascmkRFLYVRCYDSLELLSSLkyFTVLQTLhyriqqqeACGSQVGVLMIDSIGAFH 202
Cdd:cd01393    54 -------PSSELELAEALS---------RLLYFRPPDTLAHLLAL--DSLPESL--------FPPPNTSLVVVDSVSALF 107

                  ....*.
gi 1063728814 203 WTDRLS 208
Cdd:cd01393   108 RKAFPR 113
Rad51D cd19489
RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair ...
39-216 1.12e-10

RAD51D recombinase; RAD51D recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51D, together with the other RAD51 paralogs, RAD51B, RAD51C, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410897 [Multi-domain]  Cd Length: 209  Bit Score: 60.34  E-value: 1.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728814  39 PLRAGNVVEITGASTSAKTQILIQAAISCILpktwngihygGLGKLVLFLDLDCRFDVLRLSQMLKHRllqanwlgngaw 118
Cdd:cd19489     3 GLRTGEITELVGESSSGKTQLCLTAAANVAS----------RSGQNVLYIDTKSSFSARRLAQILKSR------------ 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728814 119 wqleesnvkscksaeektktVFDEELYASCMKRFLYVRCYDSLELLSslkyftVLQTLHYRIQQQEA-CGSQVGVLMIDS 197
Cdd:cd19489    61 --------------------AQDAEEIDKALQRIRVVRVFDPYELLD------LLEELRNTLSQQQEnLYSRLKLVIIDS 114
                         170
                  ....*....|....*....
gi 1063728814 198 IGAFhWTDRLSSSLALETH 216
Cdd:cd19489   115 LSAL-ISPLLGGSKHSEGH 132
Rad51B cd19493
RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair ...
40-235 2.44e-05

RAD51B recombinase; RAD51B recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51B, together with the other RAD51 paralogs, RAD51C, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410901 [Multi-domain]  Cd Length: 222  Bit Score: 45.00  E-value: 2.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728814  40 LRAGNVVEITGASTSAKTQILIQAAISCILPKTwngihYGGLGKLVLFLDLDCRFDVLRLSQMLKHRllqanwlgngaww 119
Cdd:cd19493     8 LPLGAITEITGASGSGKTQFALTLASSAAMPAR-----KGGLDGGVLYIDTESKFSAERLAEIAEAR------------- 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728814 120 qleesnvkscksAEEKTKTVFDEELYASCM-KRFLYVRCYDSLELLSSlkyftvLQTLHYRIQQqeacgSQVGVLMIDSI 198
Cdd:cd19493    70 ------------FPEAFSGFMEENERAEEMlKRVAVVRVTTLAQLLER------LPNLEEHILS-----SGVRLVVIDSI 126
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1063728814 199 gafhwtdrlsSSLALETHNRKSLSLT---NVVETIVQELK 235
Cdd:cd19493   127 ----------AALVRREFGGSDGEVTerhNALAREASSLK 156
XRCC3 cd19491
XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells ...
40-106 2.56e-05

XRCC3 recombinase; XRCC3 (X-ray repair complementing defective repair in Chinese hamster cells 3) recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. XRCC3, together with the other RAD51 paralogs, RAD51B, RAD51C, RAD51D, and XRCC2, helps recruit RAD51 to the break site.


Pssm-ID: 410899 [Multi-domain]  Cd Length: 250  Bit Score: 44.98  E-value: 2.56e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063728814  40 LRAGNVVEITGASTSAKTQILIQAAISCILPktwngIHYGGLGKLVLFLDLDCRFDVLRLSQMLKHR 106
Cdd:cd19491     9 IPVGGITEIAGESGAGKTQLCLQLALTVQLP-----RELGGLGGGAVYICTESSFPSKRLQQLASSL 70
Rad51C cd19492
RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair ...
43-202 9.28e-05

RAD51C recombinase; RAD51C recombinase, a RAD51 paralog, plays an important role in DNA repair by homologous recombination (HR). HR is an important error-free repair mechanism for chromosomal double-strand break (DSB) which otherwise leads to cell cycle arrest and death. RAD51C, together with the other RAD51 paralogs, RAD51B, RAD51D, XRCC3, and XRCC2, helps recruit RAD51 to the break site. Additionally, RAD51C acts as a mediator in the early steps of DNA damage signaling.


Pssm-ID: 410900 [Multi-domain]  Cd Length: 172  Bit Score: 42.60  E-value: 9.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728814  43 GNVVEITGASTSAKTQILIQAAISCILPKTwngihYGGLGKLVLFLDLDCRFDVlrlsqmlkhrllqanwlgngawwqle 122
Cdd:cd19492     1 GKITEICGVPGVGKTQLCMQLAVNVQIPKC-----FGGLAGEAIYIDTEGSFNI-------------------------- 49
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063728814 123 esnvkscksaeektktvfdeelyascmkrfLYVRCYDSLELLSslkyftVLQTLHYRIQQqeacGSQVGVLMIDSIgAFH 202
Cdd:cd19492    50 ------------------------------HYFRVHDYVELLA------LINSLPKFLED----HPKVKLIVVDSI-AFP 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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