|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
29-478 |
0e+00 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 610.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 29 QILVLIITFTAYASFHASRKPPSIVKSVLGPPSLNS---------SSIDNGWAPFNGTQGTKRLGELDLAFLSSYALGMY 99
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKPISIVKSVLHPNCSALipppnivlnNTTWCGWAPFDGKNGTELLGALDSAFLFAYAIGMF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 100 FAGHLGDRIDLRYFLVFGMMGSGILTLVFGLGYWMNVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNWCGKEKRGLIMGL 179
Cdd:cd17344 81 FSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLIMGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 180 WNSHTSVGNILGSVIASSVLDFGWGWSFVLPGVLVLVSGVVVFMFLVVSPndlgfeelgkeieiemslgenveeslrkhe 259
Cdd:cd17344 161 WNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP------------------------------ 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 260 aegavllenvddssfaigfleawrlPGVAPYAFCLFFSKLVAYTFLYWLPYYLRHTAvagvNLSHKTAGILSTVFDVGGV 339
Cdd:cd17344 211 -------------------------PGVIEFSLCLFFAKLVSYTFLYWLPLYISNTA----ILSAKKAGDLSTLFDVGGI 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 340 LGGISAGFISDKIKARALTSITFLALSIPALIMYRVYGSVSMFINIVLMFISGLLVNGPYALITTAVAADLGTQDSIKGN 419
Cdd:cd17344 262 VGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQVSMTTNIVLLIVCGLLVNGPYALITTAVSADLGTHKSLKGN 341
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 1063700324 420 GRALATVTAIIDGTGSVGAALGPLLAGYISSRGWNSVFFMLIVSIFFAGLFLVRLAKSE 478
Cdd:cd17344 342 ARALATVTAIIDGTGSIGAALGPLLAGLISSRGWNNVFYMLIAADVCAGLLLTRLVYKE 400
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
30-474 |
3.56e-102 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 311.56 E-value: 3.56e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 30 ILVLIITFTAYASFHASRKPPSIVKS----VLGPPSLNSSSI--DNGWAP----FNGTQGTKRLGELDLAFLSSYALGMY 99
Cdd:cd17342 2 VVVFILTFFSYALLHATRKTFSNVKPsisaEWTPSNSNTSIElhEETWNAnplfPSQDDAALFLGVLDTIFLFSYAIGLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 100 FAGHLGDRIDLRYFLVFGMMGSGILTLVFG-LGYWMNVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNWCGKEKRGLIMG 178
Cdd:cd17342 82 ISGWLGDRLNLRLVLAFGMCSSAITVFLFGvLTEWLHFYNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVLG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 179 LWNSHTSVGNILGSVIASSVLDFGWGWSFVLPGVLVLVSGVVVFMFLVVSPndlgfeelgkeieiemslgenveeslrkh 258
Cdd:cd17342 162 LWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP----------------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 259 eaegavllenvddssfaigfleawrlPGVAPYAFCLFFSKLVAYTFLYWLPYYLRhtavAGVNLSHKTAGILSTVFDVGG 338
Cdd:cd17342 213 --------------------------PGVIPYSLAYACLKLVNYSFFFWLPFYLS----NNFHWKESEADQLSIWYDVGG 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 339 VLGGISAGFISDKIKARALTSITFLALSIPALIMYRvYGSVSMFINIVLMFISGLLVNGPYALITTAVAADLGTQDSIKG 418
Cdd:cd17342 263 IIGGIVAGYISDRMGSRSPVVVVMLLLAIPSLFVYS-HSPSDKVLNAFVMTITGFFIGGPANLISSAISADLGRQPQLRG 341
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 1063700324 419 NGRALATVTAIIDGTGSVGAALGPLLAGYISSR-GWNSVFFMLIVSIFFAGLFLVRL 474
Cdd:cd17342 342 SSEALATVTGIIDGTGSIGAAIGQVLVPLIQNRlGWMWVFYFFIIMTILTIVCILPL 398
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
29-474 |
4.01e-64 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 212.13 E-value: 4.01e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 29 QILVLIITFTAYASFHASRKPPSIVKSVLGPPSLNSSSidngwapfngtqgtkRLGELDLAFLSSYALGMYFAGHLGDRI 108
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKD---------------DLGIIGSAFLIAYAVGKFISGFLSDRS 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 109 DLRYFLVFGMMGSGILTLVFGLGYWmnvhtLGFYMSVQIVCGLFQSIGWPCVVSVVGNWCGKEKRGLIMGLWNSHTSVGN 188
Cdd:cd17312 66 NIRRFMSAGLLLSALANIFMGFSTS-----LWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGG 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 189 ILGSVIASSVLD-FGWGWSFVLPGVLVLVSGVVVFMFLVVSPndlgfeelgkeieiemslgenveeslrkheaegavlle 267
Cdd:cd17312 141 ILAPILAASLASyYGWRAAFLVPGIVGLVVAIILFFFLRDSP-------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 268 nvddssfaigfleawrlPGVAPYAFCLFFSKLVAYTFLYWLPYYLRHTAvagvNLSHKTAGILSTVFDVGGVLGGISAGF 347
Cdd:cd17312 183 -----------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVK----GYSLIDAGWFSSLYEVGGIAGTILAGL 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 348 ISDKI--KARALTSITFLALSIPALIMYRVYGSvSMFINIVLMFISGLLVNGPYALITTAVAADLGTQDsikgngrALAT 425
Cdd:cd17312 242 LSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPH-NKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKE-------AAGT 313
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 1063700324 426 VTAIIDGTGSVGAALGPLLAGYISSR-GWNSVFFMLIVSIFFAGLFLVRL 474
Cdd:cd17312 314 ATGFVGLFGYLGASLAGLPLGYIIDHyGWSTVFYFLISAALLSVLLLLSL 363
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
29-472 |
1.19e-32 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 128.51 E-value: 1.19e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 29 QILVLIITFTAYASFHASRKPPSIVKSVLgppslnssSIDNGWApfngtqgTKRLGELDLAFLSSYALGMYFAGHLGDRI 108
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYL--------IEQYGLS-------KTEIGLIGSALSIAYGLSKFVMGNLSDRS 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 109 DLRYFLVFGMMGSGILTLVFGLGYWMNVhTLGFYMSVQIVCGLFQSIGWPCVVSVVGNWCGKEKRGLIMGLWN-SHTSVG 187
Cdd:cd17345 66 NPKRFLAIGLILSAIINILIGFVPSATS-SVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNiSHNVGG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 188 NILGSVIASSVLDFG---WGWSFVLPGVLVLVSGVVVFMFLVVSPNDLGFEelgkeiEIEMSLGENVEESLRKHEAEgav 264
Cdd:cd17345 145 GLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLP------PIEEYKGDYPEEADGEEEEQ--- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 265 llenvDDSSFAIGFLEAWRLPGVAPYAFCLFFSKLVAYTFLYWLPYYLrhTAVAGvnLSHKTAGILSTVFDVGGVLGGIS 344
Cdd:cd17345 216 -----ELSAWEIFVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYL--SEVKG--FSKAQAMWAFSLFEWAAIPGTLL 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 345 AGFISDKIKA--RALTSITFLALSIPALIMYrvYGSVSMFINIVLMFISGLLVNGPYALITTAvAADLGTqdsikgngRA 422
Cdd:cd17345 287 AGWLSDKLFKgrRAPTGIIFMILVIVALIVY--WLAPNVLVDLIALIALGFLIYGPVMLIGLQ-ALELVP--------KK 355
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 1063700324 423 LATVTAIIDGTGS--VGAALGPLLAGYISSR-GWNSVFFMLIVSIFFAGLFLV 472
Cdd:cd17345 356 AAGTAAGLTGLFGylGGSVLATALIGIIVDHfGWNGGFIVLLASCILAIIFLA 408
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
89-476 |
2.09e-29 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 118.43 E-value: 2.09e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 89 AFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLgywmnVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNWC 168
Cdd:COG2271 53 AFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWF 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 169 GKEKRGLIMGLWNSHTSVGNILGSVIASSVLD-FGWGWSFVLPgvlvlvsgvvvfmflvvspndlgfeelgkeieiemsl 247
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLAaFGWRAAFLIL------------------------------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 248 genveeslrkheaeGAVllenvddsSFAIGFLEAWRLpgvapyAFCLFFSKLVAYTFLYWLPYYLrhtaVAGVNLSHKTA 327
Cdd:COG2271 171 --------------GLP--------GLLLALLRFWLL------ALAYFLVYFALYGFLTWLPTYL----VEVRGLSLAQA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 328 GILSTVFDVGGVLGGISAGFISDKI-KARALTSITFLALSIPALIMYRVYGSVSMFIniVLMFISGLLVNGPYALITTAV 406
Cdd:COG2271 219 GLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAALALLLLALLPSPALAI--ALLFLAGFGLGGAFGLLWALA 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063700324 407 AADLGTqdsikgngRALATVTAIIDGTGSVGAALGPLLAGYISSR-GWNSVFFMLIVSIFFAGLFLVRLAK 476
Cdd:COG2271 297 AELFPK--------KARGTASGLVNTFGFLGGALGPLLVGYLLDAtGYQAAFLLLAALALLAALLALLLLR 359
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
83-457 |
4.47e-26 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 109.39 E-value: 4.47e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 83 LGELDLAFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGlgyWMNvhTLGFYMSVQIVCGLFQSIGWPCVVS 162
Cdd:TIGR00881 32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG---FST--SLWVMAALWALNGIFQGMGWPPCGR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 163 VVGNWCGKEKRGLIMGLWNSHTSVGNILGS--VIASSVLDFGWGWSFVLPGVLVLVSGVVVFMFLVVSPNDLGFEELGKE 240
Cdd:TIGR00881 107 TVTKWFSRSERGTWVSFWNCSHNVGGGLLPplVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEM 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 241 -IEIEMSLGENVEESLRKHEAegavLLENVDDSSFAIGFleawrlpgvapyAFCLFFSKLVAYTFLYWLPYYLrhTAVAG 319
Cdd:TIGR00881 187 pNEEPDGDAEKKEEELTKKQI----FLQYVLLNKVLWYI------------SLGYVFVYVVRTGILDWSPLYL--TQEKG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 320 VnlSHKTAGILSTVFDVGGVLGGISAGFISDKI--KARALTSITFLALSIPALIMYRVYGSVSMFINIVLMFISGLLVNG 397
Cdd:TIGR00881 249 F--SKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYG 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063700324 398 PYALIttavaadlGTQDSIKGNGRALATVTAIIDGTGSVGAALGPLLAGYISSR-GWNSVF 457
Cdd:TIGR00881 327 PQMLI--------GVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGfGWAGAF 379
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
89-474 |
4.26e-22 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 97.64 E-value: 4.26e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 89 AFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLgywmnVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNWC 168
Cdd:cd17319 46 AFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF-----ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 169 GKEKRGLIMGLWNSHTSVGNILGS-VIASSVLDFGWGWSFVLpgvlvlvsgvvvfmflvvspndlgfeelgkeieiemsl 247
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPpLSGWLLLLFGWRWAFII-------------------------------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 248 genveeslrkheaEGAVllenvddsSFAIGFLEAWRLPGVAPYAFCLFFSKLVAYTFLYWLPYYLRHTAvagvNLSHKTA 327
Cdd:cd17319 163 -------------EGLL--------GLLLAVLWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQAR----GFSLKQV 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 328 GILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMYRVYGSVSMFINIVLMFISGLLVNGPYALITTAVA 407
Cdd:cd17319 218 GLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPA 297
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063700324 408 ADLGtqdsikgnGRALATVTAIIDGTGSVGAALGPLLAGYISSR--GWNSVFFMLIVSIFFAGLFLVRL 474
Cdd:cd17319 298 DLLP--------GEAAATAGGLINSGGNLGGFVAPLLIGYLVDAtgSYTAAFLFLAAVALLAALLVLLL 358
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
80-484 |
4.59e-20 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 92.80 E-value: 4.59e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 80 TKRLGELDLAFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLGYWMNVHTLGFYMSVQIVCGLFQSIGWPC 159
Cdd:PRK09556 63 TTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPC 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 160 VVSVVGNWCGKEKRGLIMGLWN-SHTSVGNILGSVI---ASSVLDFGWGWSFVLPGVLVLVSGVVVFMFLVVSPNDLGfe 235
Cdd:PRK09556 143 SYSTITRWTPRRKRGRFLGFWNiSHNLGGAGAGGVAlwgANYFFDGHVIGMFIFPSIIALIIGFIGLRYGSDSPEELG-- 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 236 eLGKEIEIemsLGENVEESlrkheaegAVLLENVDDSSFAIgfLEAWRLPGVAPYAFClffsklVAYTFLY--------W 307
Cdd:PRK09556 221 -WGKAEEI---FGEPISEE--------DKETESTDMTKWQI--FVEYVLKNPVIWLLC------FANIFLYivrigidnW 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 308 LPYYlrhtAVAGVNLSHKTAGILSTVFDVGGVLGGISAGFISDKIKA-RALTSITFLALSIPALIMYRVYGSVSMFinIV 386
Cdd:PRK09556 281 SPVY----AFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANGrRALVACIALALIIFTLGVYQHATSEYMY--LA 354
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 387 LMFISGLLVNGPYALITTAVAA-----DLGTQDSIKGN-----GRALATV--TAIIDGTGSVGAALGPLLagyissRGWN 454
Cdd:PRK09556 355 SLFALGFLVFGPQLLIGVAAVGfvpkkAIGVANGIKGTfaylfGDSFAKVglGMIADPTKNGTPIFGYTL------TGWA 428
|
410 420 430
....*....|....*....|....*....|
gi 1063700324 455 SVFFMLIVSIFFAGLFLVRLAKSEINTMRS 484
Cdd:PRK09556 429 GTFAALDIAAIGCICLMAIVAVMEERKIRR 458
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
89-474 |
3.27e-18 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 86.47 E-value: 3.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 89 AFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLgywmnVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNWC 168
Cdd:COG2223 48 IPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLAL-----AVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWF 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 169 GKEKRGLIMGLWNSHTSVGNILGSVIASSVLD-FGWGWSFVLPGVLVLVSGVVVFMFLVVSPNDLGFEElgkeieiemsl 247
Cdd:COG2223 123 PPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAaFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAA----------- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 248 genvEESLRkheaegavllenvddssfaiGFLEAWRLPGVAPYAFCLFFSKLVAYTFLYWLPYYLrhtaVAGVNLSHKTA 327
Cdd:COG2223 192 ----KASLR--------------------DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYL----VDQFGLSAATA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 328 GILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMYRVYGSVSMFinIVLMFISGLLVNGPYALITTAVA 407
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLF--LVLFLLLGLALGGGNGAVFALVP 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063700324 408 ADLGTqdsikgngRALATVTAIIDGTGSVGAALGPLLAGYISSR--GWNSVFFMLIVSIFFAGLFLVRL 474
Cdd:COG2223 322 DIFPT--------KNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtgSYTAAFLVFAVLALVALVLTLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
89-436 |
3.64e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 82.71 E-value: 3.64e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 89 AFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLgywmnVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNWC 168
Cdd:COG2814 53 AYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL-----APSLWLLLAARFLQGLGAGALFPAALALIADLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 169 GKEKRGLIMGLWNSHTSVGNILGSVIASSVLD-FGWGWSFVLPGVLVLVSGVVVFMFLVVSPndlgfeelgkeieiemsl 247
Cdd:COG2814 128 PPERRGRALGLLGAGLGLGPALGPLLGGLLADlFGWRWVFLVNAVLALLALLLLLRLLPESR------------------ 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 248 genveeslrkheaegavlleNVDDSSFAIGFLEAWRLPGVAPYAFCLFFSKLVAYTFLYWLPYYLRHTAvagvNLSHKTA 327
Cdd:COG2814 190 --------------------PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL----GLSASAA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 328 GILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMYRVYGSVSMFInivLMFISGLLVNGPYALITTAVA 407
Cdd:COG2814 246 GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLL---ALFLLGFGFGLLFPLLQALVA 322
|
330 340
....*....|....*....|....*....
gi 1063700324 408 ADLGTQDSikgnGRALATVTAIIDGTGSV 436
Cdd:COG2814 323 ELAPPEAR----GRASGLYNSAFFLGGPL 347
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
83-471 |
1.26e-16 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 82.07 E-value: 1.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 83 LGELDLAFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLGywmnvHTLGFYMSVQIVCGLFQSIGWPCVVS 162
Cdd:PRK11663 60 IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFS-----SSLWAFALLWVLNAFFQGWGWPVCAK 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 163 VVGNWCGKEKRGLIMGLWN-SHTSVGNILGSVIASSVLDFGWGWSFVLPGVLVLVSGVVVFMFLVVSPNDLGFEELGKEI 241
Cdd:PRK11663 135 LLTAWYSRTERGGWWAIWNtAHNVGGALIPLVVGAIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWR 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 242 EIEMSLGenveeslrkHEAEGAVLLENVDDSSFAIGFLEAWRLpgvapyAFCLFFSKLVAYTFLYWLPYYLrhTAVAGVN 321
Cdd:PRK11663 215 HDALELA---------QQQEGAGLSRKEILTKYVLLNPYIWLL------SFSYVLVYVVRAAINDWGNLYM--SETLGVD 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 322 LShkTAGILSTVFDVGGVLGGISAGFISDKI--KARALTSITFLA---LSIPALIMyrvYGSVSMFINIVLMFISGLLVN 396
Cdd:PRK11663 278 LV--TANSAVSMFELGGFIGALVAGWGSDKLfnGNRGPMNLIFAAgilLSVGSLWL---MPFASYVMQAACFFTIGFFVF 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 397 GPYALITTAvAADLGTQDSIkgnGRAlatvtaiidgTGSVG--AALGPLLAGYISSR-----GWNSVFFMLIVSIFFAGL 469
Cdd:PRK11663 353 GPQMLIGMA-AAECSHKEAA---GAA----------TGFVGlfAYLGAALSGYPLAKvleiwHWTGFFVVISIAAGISAL 418
|
..
gi 1063700324 470 FL 471
Cdd:PRK11663 419 LL 420
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
93-473 |
4.00e-16 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 80.07 E-value: 4.00e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 93 SYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGlgYWMNVHTLGFYMSVQivcGLFQSIGWPCVVSVVGNWCGKEK 172
Cdd:cd17343 50 AYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFS--GSSSVWVFSILWFLN---GLAQGLGWPPCAKILRKWFSPSQ 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 173 RGLIMGLWNSHTSVGNILGSVIASSV-LDFGWGWSFVLPGVLVLVSGVVVFMFLVVSPNDLGFEELGKEIEIEMSLGENV 251
Cdd:cd17343 125 FGTWWSVLSTSMNLAGSLGPILATLLaLSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKKKKSPR 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 252 EESLRKheaegavllenvddssfaigflEAWRLPGVAPYAFCLFFSKLVAYTFLYWLPYYLrhtaVAGVNLSHKTAGILS 331
Cdd:cd17343 205 GESTLK----------------------ELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFL----IQDKGQSALTGSSFM 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 332 TVFDVGGVLGGISAGFISDKIKAR-------------ALTSITFLALSIPALIMYRVYGSVSMFINiVLMFISGLLVNGP 398
Cdd:cd17343 259 SSLEVGGFVGSIAAGYLSDWAVAKhgsssrgnprmplALVFMAGLTVSLHLFRVHITSDSSELFIL-LLGFLIGFSLYGP 337
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063700324 399 YALIttAVAADLGTQDSIKGngralaTVTAIIDGTGSVGAALGPLLAGYISS-RGWNSVFFMLIVS--IFFAGLFLVR 473
Cdd:cd17343 338 IAIF--GVIANESAPSHLCG------TSHAIVALAANVGGVLAGLPFSYIAKhYDWRTAFLLLEILcaITVVILFLLR 407
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
89-442 |
7.67e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 78.61 E-value: 7.67e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 89 AFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLgywmnVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNWC 168
Cdd:pfam07690 40 LFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF-----ASSLWLLLVLRVLQGLGAGALFPAALALIADWF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 169 GKEKRGLIMGLWNSHTSVGNILGSVIASSVLD-FGWGWSFVLPGVLVLVSGVVVFMFLvvspndlgfeelgkeieiemsl 247
Cdd:pfam07690 115 PPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAILSLLAAVLLLLPR---------------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 248 genveeslrkHEAEGAVLLENVDDSSFAIGFLEAWRLPGVAPYAFCLFFSKLVAYTFLYWLPYYLRHtavagVNLSHKTA 327
Cdd:pfam07690 173 ----------PPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-----LGLSALLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 328 GILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMYRVYGSVSMFINIVLMFISGLLVNGPYALITTAVA 407
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVS 317
|
330 340 350
....*....|....*....|....*....|....*
gi 1063700324 408 ADLGTqdsikgngRALATVTAIIDGTGSVGAALGP 442
Cdd:pfam07690 318 DLAPK--------EERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
93-475 |
5.89e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 76.46 E-value: 5.89e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 93 SYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLgywmnVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNWCGKEK 172
Cdd:cd17325 43 AQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF-----ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 173 RGLIMGLWNSHTSVGNILGSVIASSVLD-FGWGWSFVLPGVLVLVSGVVVFMFLvvspndlgfEELGKEIEIEMSLGENV 251
Cdd:cd17325 118 RGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAALALLALVLALLLL---------PEPRPPPNKRAVSAARL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 252 EESLRKHEAEGAVLLenvddssfaigfleawrlpgvapYAFCLFFSKLVAYTFLYWLPYYLRHTavagVNLSHKTAGILS 331
Cdd:cd17325 189 RSGLRLLLRDRRLLA-----------------------LFLAIFVLAFAFGALEPFLPLYAAEL----GGLSPAQIGLLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 332 TVFDVGGVLGGISAGFISDKIKAR--ALTSITFLALSIPALIMyrvygSVSMFINIVLMFISGLLvngpYALITTAVAAD 409
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRIGRKplILIGLLLSAVALLLLPL-----ATSFWLLLLLLALLGLG----LGLVFPATLAL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063700324 410 LGTQDSIKGNGRALATVTAIIDgtgsVGAALGPLLAGYISSR-GWNSVFFMLIVSIFFAGLFLVRLA 475
Cdd:cd17325 313 LADIVPPEGRGTAMGLFNTAFS----LGMVLGPLLGGFLYDAfGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
83-474 |
6.37e-14 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 73.21 E-value: 6.37e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 83 LGELDLAFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLGywmnvHTLGFYMSVQIVCGLFQSIGWPCVVS 162
Cdd:cd17488 40 IGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFS-----SSLWAFAVLWTLNAFFQGWGWPPCAR 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 163 VVGNWCGKEKRGLIMGLWN-SHTSVGNILGSVIASSVLDFGWGWSFVLPgvlvlvsgvvvfmflvvspndlgfeelgkei 241
Cdd:cd17488 115 LLTHWYSRNERGFWWSIWNtSHNIGGALIPILTGFAALTYGWRAGMYVP------------------------------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 242 eiemslgenveeslrkheaeGAVllenvddsSFAIGFLEAWRLPGVAPYAFCLFFSKLVAYTFLY----WLPYYLrhTAV 317
Cdd:cd17488 164 --------------------GII--------AILMGIVLCWRLRDRPPYIWLLAFCYVLVYVVRTaindWGNLYL--SET 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 318 AGVNLShkTAGILSTVFDVGGVLGGISAGFISDKIKA--RALTSITF---LALSIPALIMYRVYgsvSMFINIVLMFISG 392
Cdd:cd17488 214 HGYSLV--KANSAVSLFEVGGLIGALVAGWGSDKLFKgnRGPMNLIFalgLLVSVGALWLVPVH---SYWLLATCFFTIG 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 393 LLVNGPYALITTAvAADLGTQDsikgngrALATVTAIIDGTGSVGAAL-GPLLAGYISSRGWNSVFFMLIVSIFFAGLFL 471
Cdd:cd17488 289 FFVFGPQMLIGMA-AAECSHKD-------AAGSATGFVGLFAYLGAALaGYPLAKVIESWGWSGFFIVISIAAAISGLLL 360
|
...
gi 1063700324 472 VRL 474
Cdd:cd17488 361 LPL 363
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
94-481 |
6.40e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 70.29 E-value: 6.40e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 94 YALGMYFAGHLGDRIDLRYFLVFGM--MGSGILTLVFGLGYWMnvhtlgFYMSvQIVCGLFQSIGWPCVVSVVGNWCGKe 171
Cdd:COG2807 66 FGLFAPLAPRLARRFGLERTLLLALllLAAGLLLRSLAPSVAL------LLAG-TALIGAGIAVGNVLLPGLIKRWFPD- 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 172 KRGLIMGLWNSHTSVGNILGSVIASSVLD-FGWGWSFVLpgvlvlVSGVVVFMFLVVSPNdlgfeelgkeieiemslgen 250
Cdd:COG2807 138 RVGLMTGLYTAAMGLGAALAAGLTVPLAAaLGWRGALAV------WALLALLALLLWLPL-------------------- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 251 veesLRKHEAEGAvllenvdDSSFAIGFLEAWRLPGVAPYAFCLFFSKLVAYTFLYWLPYYLRHtavAGVNLShkTAGIL 330
Cdd:COG2807 192 ----LRRRPAAAA-------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD---AGLSAA--TAGLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 331 STVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMYRVYGSVSMFINIVLMfisGLLVNGPYALITTAVAADL 410
Cdd:COG2807 256 LSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLL---GLGQGGLFPLALTLIGLRA 332
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063700324 411 GTqdsikgnGRALATVTAIIDGTGSVGAALGPLLAGYISSR--GWNSVFFMLIVSIFFAGLFLVRLAKSEINT 481
Cdd:COG2807 333 RT-------PAEAAALSGMAQSVGYLLAALGPLLVGALHDAtgSWTAALLLLAALAVLMLVAGLLAGRPYVED 398
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
89-472 |
2.29e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 68.22 E-value: 2.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 89 AFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLgywmnVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNWC 168
Cdd:cd06174 39 LFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF-----APSFWLLLLGRFLLGLGSGLIDPAVLALIADLF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 169 GKEKRGLIMGLWNSHTSVGNILGSVIASSVLD-FGWGWSFVLPGVLVLVSGVVVFMFLVVSPNDLGFEELGKEIEIemsl 247
Cdd:cd06174 114 PERERGRALGLLQAFGSVGGILGPLLGGILASsLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASS---- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 248 genveeslrkheaegavllenvddSSFAIGFLEAWRLPGVAPYAFCLFFSKLVAYTFLYWLPYYLRHTAVAGVnlshKTA 327
Cdd:cd06174 190 ------------------------KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSV----AVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 328 GILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMYRVYGSVSMFinIVLMFISGLLVNGPYALITTAVA 407
Cdd:cd06174 242 GLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLL--LLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063700324 408 ADLgtqdsikgNGRALATVTAIIDGTGSVGAALGPLLAGYISSR--GWNSVFFMLIVSIFFAGLFLV 472
Cdd:cd06174 320 ELF--------PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtfGLTGAFLVLAVLLLLAAILLL 378
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
95-448 |
1.44e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 66.23 E-value: 1.44e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 95 ALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLvfGLGYWMNVHTLGFYmsvQIVCGLFQSIGWPCVVSVVGNWCGKEKRG 174
Cdd:TIGR00895 66 AFGALFFGPLADRIGRRRVLLWSILLFSVFTL--LCALATNVTQLLIL---RFLAGLGLGGLMPNLNALVSEYAPKRFRG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 175 LIMGLWNSHTSVGNILGSVIASSVL-DFGWGWSFVLPGVLVLVSGVVVFMFLvvsPNDLGFEELGKEIEIEMSLGENVEE 253
Cdd:TIGR00895 141 TAVGLMFCGYPIGAAVGGFLAGWLIpVFGWRSLFYVGGIAPLLLLLLLMRFL---PESIDFLVSKRPETVRRIVNAIAPQ 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 254 SLRKHEAEGAVLLENVDDSSFAIGFLEAWRLPGVAPYAFCLFFSKLVAYTFLY-WLPYYLRHTavaGVNLSHktAGILST 332
Cdd:TIGR00895 218 MQAEAQSALPEQKSTQGTKRSVFKALFQGKTARITVLLWLLYFMLLVGVYFLTnWLPKLMVEL---GFSLSL--AATGGA 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 333 VFDVGGVLGGISAGFISDKIKARALTSITFLAlsipALIMYRVYGSVSMFINIVLM-FISGLLVNGPYALITTAVAADLG 411
Cdd:TIGR00895 293 LFNFGGVIGSIIFGWLADRLGPRVTALLLLLG----AVFAVLVGSTLFSPTLLLLLgAIAGFFVNGGQSGLYALMALFYP 368
|
330 340 350
....*....|....*....|....*....|....*..
gi 1063700324 412 TQdsikgnGRALATVTAIidGTGSVGAALGPLLAGYI 448
Cdd:TIGR00895 369 TA------IRATGVGWAI--GIGRLGAIIGPILAGYL 397
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
95-475 |
2.09e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 65.30 E-value: 2.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 95 ALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLvfGLGYWMNVHTLGFYmsvQIVCGLFQSIGWPCVVSVVGNWCGKEKRG 174
Cdd:cd17365 48 AIGALLAGPLADRFGRKRVLLVSVALFGLFTL--LTAFAQSVLQLALL---RFLTGLGLGAAMPNAITLVSEYAPARRRS 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 175 LIMGLWNSHTSVGNILGSVIASSVLDfGWGWSFVLpgvlvlvsGVVVFMFLVVSPndlgfeelgkeieiemslgenvees 254
Cdd:cd17365 123 LAVTLMFCGYPLGAALGGFLAAALIP-AFGWRSVF--------LLGGVPPLILLP------------------------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 255 lrkheaegavllenvddssFAIGFLEAWrlpgvapyaFCLFFSKLVAYTFLYWLPYYLRHtavAGVNLSHktAGILSTVF 334
Cdd:cd17365 169 -------------------LLRGTLLLW---------VTFFMGLLLVYLLNSWLPKLMVE---AGYSLSQ--ALTITLLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 335 DVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMYRVYGSVSMFinIVLMFISGLLVNGPYALITTAVAADLGTQd 414
Cdd:cd17365 216 NIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLL--YVLVFLAGACVNGAQVGLYALAARFYPTE- 292
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063700324 415 sikgnGRALATVTAIidGTGSVGAALGPLLAGYISSRGW--NSVFFMLIVSIFFAGLFLVRLA 475
Cdd:cd17365 293 -----VRATGVGWAL--GVGRLGAILGPLLGGLLLAAGLgpESVFLALAIPAALGALAVLLLR 348
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
94-472 |
6.34e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 63.72 E-value: 6.34e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 94 YALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLgywmnVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNWCGKEKR 173
Cdd:cd17324 47 YALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL-----APSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKR 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 174 GLIMGLWNSHTSVGNILGSVIASSVLD-FGWGWSFVLPGVLVLVSGVVVFMFLvvsPNDLGFEELGKEIEIEMSLgenve 252
Cdd:cd17324 122 GRAIGLVFSGLTLGLVLGRPLGGLLGQlLGWRAAFLAIAVLALLAALLLWRLL---PSLPPKKPGSLGLLSSLLL----- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 253 eslrkheaegavllenvddssfaigFLEAWRLPGVAPYAFCLFFSKLVAYTFlywLPYYLrhTAVAGVnLSHKTAGILSt 332
Cdd:cd17324 194 -------------------------LLRNPRLRLAYLITFLLFGGFFALYTY---LAPFL--TDVPGF-SSSAIIGLLL- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 333 VFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMYRVYGSVSMFINIVLMFISGLLVNGPYALITTAVAADlgt 412
Cdd:cd17324 242 LFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPE--- 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 413 qdsikgngrALATVTAIIDGTGSVGAALGPLLAGYISSRGWNSVFFMLIVSIFFAGLFLV 472
Cdd:cd17324 319 ---------ARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLA 369
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
73-478 |
8.61e-11 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 63.96 E-value: 8.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 73 PFNGTQGTKRlGELDLAFLS---SYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLGYWMNvHTLGFYMSVQIVC 149
Cdd:PRK11273 53 PYLVEQGFSR-GDLGFALSGisiAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVPWAT-SSIAVMFVLLFLC 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 150 GLFQSIGWP-CVVSVVGNWCGKEkRGLIMGLWN-SHTSVGNILGSVIASSVLDFG-WGWSFVLPGVLVLVSGVVVFMFLV 226
Cdd:PRK11273 131 GWFQGMGWPpCGRTMVHWWSQKE-RGGIVSVWNcAHNVGGGLPPLLFLLGMAWFNdWHAALYMPAFAAILVALFAFAMMR 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 227 VSPNDLGFEelgkeiEIEMSLGENVEESLRKHEAE---GAVLLENVDDSSFaigfleAWRLpgvapyAFCLFFSKLVAYT 303
Cdd:PRK11273 210 DTPQSCGLP------PIEEYKNDYPDDYNEKHEQEltaKQIFMQYVLPNKL------LWYI------AIANVFVYLLRYG 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 304 FLYWLPYYLRHTAVAGVNLShKTAGILstvFDVGGVLGGISAGFISDKI--KARALTSITFLALSIPALIMYRVYGSVSM 381
Cdd:PRK11273 272 ILDWSPTYLKEVKHFALDKS-SWAYFL---YEYAGIPGTLLCGWMSDKVfrGNRGATGVFFMTLVTIATIVYWLNPAGNP 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 382 FINIVLMFISGLLVNGPYALITTAvAADLGTQdsiKGNGRAlATVTAIIDGTGsvGAALGPLLAGY-ISSRGWNSVFFML 460
Cdd:PRK11273 348 TVDMACMIVIGFLIYGPVMLIGLH-ALELAPK---KAAGTA-AGFTGLFGYLG--GSVAASAIVGYtVDFFGWDGGFMVM 420
|
410
....*....|....*...
gi 1063700324 461 IVSIFFAGLFLVRLAKSE 478
Cdd:PRK11273 421 IGGSILAVILLIVVMIGE 438
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
83-476 |
7.86e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 60.64 E-value: 7.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 83 LGELDLAFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLgywmnVHTLGFYMSVQIVCGLFQSIGWpCVVS 162
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFAL-----APSYPLLLLALFLLGLGLGLLD-VAAN 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 163 VVGNWCGKEKRGLIMGLWNSHTSVGNILGSVIASSVLDFGWGWSFVLPGVLVLVSGVVVFMFLVVSPndlgfeelgkeie 242
Cdd:COG0738 119 PYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSK------------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 243 iemslgenveesLRKHEAEGAvllenvDDSSFAIGFLEAWRLPGVAPYAFCLFFSKLVAYTFLYWLPYYLRHtavaGVNL 322
Cdd:COG0738 186 ------------LPEIEEEEE------EAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKD----VLGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 323 SHKTAGILSTVFDVGGVLGGISAGFISDKIKARALTSItFLALSIPALIMyrVYGSVSMFINIVLMFISGLLVNGPYALI 402
Cdd:COG0738 244 SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRL-SALLAAVGLLL--ALLAPGPWLALIGLALVGLGLSLMFPTI 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063700324 403 TTAVAADLgtqdsikgnGRALATVTAIIDGTGSVGAALGPLLAGYISSR-GWNSVFFMLIVSIFFAGLFLVRLAK 476
Cdd:COG0738 321 FSLALDGL---------GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAfGLRAAFLVPLVCYLLILLLALALKR 386
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
79-450 |
2.19e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 59.17 E-value: 2.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 79 GTKRLGELDLAFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGL--GYWMnvhtlgFYMSVQIVcGLFQSIG 156
Cdd:cd17328 32 DDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFapNFWQ------LLLFRALV-GIGEASY 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 157 WPCVVSVVGNWCGKEKRGLIMGLWNSHTSVGNILGSVIASSV--LDFGWGWSFVLPGVLVLVSGVVVFMFlVVSPNDLGF 234
Cdd:cd17328 105 SPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaqATGGWRWAFRVTGVLGVLLAILLLLF-VREPPRGAA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 235 EELGKEIEIEMSLGENVEESLRKHeaegavllenvddsSFAIGFLEAWrlpgvapyafCLFFsklVAYTFLYWLPYYLRH 314
Cdd:cd17328 184 EGGVMAKSTATSFLADLKALAKNP--------------SFILSTLGFT----------AVSF---VTGALAFWAPTFFLR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 315 TAVAGVNLSHKTAGILSTVFDVGGVLGGISAGFISDKI-----KARALTSITFLALSIPALIMYRVYGSVSMFINIVLMF 389
Cdd:cd17328 237 AFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLrrktpRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLF 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063700324 390 ISGLLVNGPYALITTAVaadlgtQDSIKGNGRALAtvTAI-IDGTGSVGAALGPLLAGYISS 450
Cdd:cd17328 317 LGEFLLSLNWAPVFAIL------LYVVIPTRRSTA--SAIqILLSHLLGDAGSPYLIGLISD 370
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
88-474 |
9.08e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 57.24 E-value: 9.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 88 LAFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLGYWMNVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNW 167
Cdd:cd06173 41 AAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPEL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 168 CGKEKRGLIMGLWNSHTSVGNILGSVIASSVLD-FGWGWSFVLpgvlvlvsgvVVFMFLVVSPndlgfeelgkeieiems 246
Cdd:cd06173 121 VPKEQLVRANALNSLATQLARIIGPALGGLLVAlLGPGGAFAI----------NALSFLLSAL----------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 247 lgenVEESLRKHEAEGAVLLENVDDSSFAIGFLEAWRLPGVAPYAFCLFFSKLVAYTFLYWLPYYLRHTavagVNLSHKT 326
Cdd:cd06173 174 ----LLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEV----LGGGAAG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 327 AGILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMyrvYGSVSMFINIVLMFISGLLvnGPYALITTAV 406
Cdd:cd06173 246 YGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVL---GLSPSLWLLLAALFLLGLA--GGLFNVPLNT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063700324 407 AADLGTQDSIKgnGRALATVTAIIDGTGSVGAALGPLLAGYISSRGwnsVFFMLIVSIFFAGLFLVRL 474
Cdd:cd06173 321 LLQLRVPDELR--GRVFSVYNALNSGAMPLGALLAGLLADALGLSA---VFLLAGALLLLAALLLLLL 383
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
101-472 |
2.90e-08 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 55.70 E-value: 2.90e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 101 AGHLGDRIDLRYFLVFGMMGSGILTLVFGLGYWMNVhtlGFYMSVQIVCGLFQSIGWPCVVSVVGNWCGKEKRGLIMGLW 180
Cdd:cd17318 76 GGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGY---GALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIA 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 181 NSHTSVGNI----LGSVIASSvldfgWGWSFVlpgvlvlvsgvvvfmFLVVSpndlgfeelgkeieiemslgenveeslr 256
Cdd:cd17318 153 YSGSQFGTViampLSGFLCES-----LGWPSI---------------FYIFG---------------------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 257 kheaegavllenvddsSFAIGFLEAWRLPGVAPYA--FCLFFSKLVAYTFLYWLPYYLRHtaVAGVNLshKTAGILSTVF 334
Cdd:cd17318 185 ----------------GLGLLWCLLWFFLVLPVWAivVAHFGHNWGFYTLLTELPTYMSD--VLHFNI--KSNGFLSSLP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 335 DVGGVLGGISAGFISDKIKARALTSITFlalsipaliMYRVYGSVSMFINIVLMFISGLLVNGPY---ALITTAVAADLG 411
Cdd:cd17318 245 YLAMWICSIVGGYLADWLRSRGILSTTT---------VRKLFTSIGFLGPGVFLIALGYLGSNATlavVFLTLSVGLSGA 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063700324 412 TQDSIKGNGRALA-----TVTAIIDGTGSVGAALGPLLAGYI-----SSRGWNSVFFMLIVSIFFAGLFLV 472
Cdd:cd17318 316 CYSGFLVNHLDLApnyagTLMGITNTAATIAGIISPLIVGAIvkndqTIGQWRIVFFISAAIYILGAIFYL 386
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
295-472 |
8.82e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 54.14 E-value: 8.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 295 FFSKLVAYTFLYWLPYYLRHTAvagvNLSHKTAGILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMYr 374
Cdd:cd17316 187 FFISFGYYGLTTFLPTYLQTVL----GLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLF- 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 375 VYGSVSMFINIVLMFISGLLVNGPYALITTAVAADLGTqdsikgngRALATVTAIIDGTGSVGAALGPLLAGYISSRGWN 454
Cdd:cd17316 262 YLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPT--------EVRATGVGLSYNLGRLGGGGAPPLIALLLASTGG 333
|
170
....*....|....*...
gi 1063700324 455 SVFFMLIVSIFFAGLFLV 472
Cdd:cd17316 334 TGVPALILALLAIVALIV 351
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
88-209 |
9.27e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.12 E-value: 9.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 88 LAFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLgywmnVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNW 167
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL-----ATSFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1063700324 168 CGKEKRGLIMGLWNSHTSVGNILGSVIASSVLD-FGWGWSFVL 209
Cdd:cd17325 317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDaFGFATPFLA 359
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
89-209 |
2.26e-07 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 52.94 E-value: 2.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 89 AFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGlgyWMNVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNWC 168
Cdd:cd17380 42 SFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTP---LLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWV 118
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1063700324 169 GKEKRGLIMGLWNSHTSVGNILGSVIASSVLD-FGWGWSFVL 209
Cdd:cd17380 119 PVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEyYGWPSVFYF 160
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
83-471 |
4.47e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 51.94 E-value: 4.47e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 83 LGELDLAFLSSYALGMYFAGHLGDRIDLRYFLVFGMmgsgiltLVFGLGYWmnVHTLGFYMSVQIVCGLFQSIGWPCVVS 162
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGL-------LLISLALA--LIFATPSIYLFVVLMFLAGLGAGILDT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 163 VVGNWCG---KEKRGLIMGLWNSHTSVGNILGSVIASSVLD--FGWGWSFVLPGVLVLVSGVVVFMFLvvspndlgFEEL 237
Cdd:cd17333 104 GANTFVGalfEESSATRLNVLHGFFGLGALIGPLIATSLLTseLSWSWAYLIIGLIYLLLAILILLTL--------FPEL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 238 GKeieiemslgenveeslrkheaegaVLLENVDDSSFAIGFLEAWRLPGVAPYAFCLFFSKLVAYTFLYWLPYYLrhtaV 317
Cdd:cd17333 176 PS------------------------ARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYL----V 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 318 AGVNLSHKTAGILSTVFDVGGVLGGISAGFISDKIKARALtsiTFLALSIPALIMYRVYGSVSMFINIVLMFISGLLVNG 397
Cdd:cd17333 228 EKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTL---LVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAA 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063700324 398 PYALITTavaadlgtqDSIKGNGRALATVTAIIDGTGSVGAALGPLLAGYISSRGwNSVFFMLIVSIFFAGLFL 471
Cdd:cd17333 305 LFPTILS---------LGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAV-GIQTAMLLITILYAIIFV 368
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
95-472 |
7.37e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 51.15 E-value: 7.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 95 ALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLGywMNVHTLGFYMSVQivcGLFQSIGWPCVVSVVGNWCGKEKRG 174
Cdd:cd17371 48 AIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA--QNYWQLLILRALA---GLGFGGEWAAGAALMAEYVPARHRG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 175 LIMGLWNSHTSVGNILGSVIASSVL-----DFGWGWSFVLpgvlvlvSGVVVFMFLVVSPNdlgfeelgkeieiemslge 249
Cdd:cd17371 123 KALGYVQSGWAVGWLLATLLAALLFpllppEIAWRVLFLL-------GALPALLVLFIRRF------------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 250 nVEESLRKHEAEGAvllENVDDSSFAIGFLEAWRLPGVAPYAFCLF-FSKLVAYTFLYWLPYYLRHTAvagvNLSHKTAG 328
Cdd:cd17371 177 -VKEPPQWQAARAA---RRHFADRPSLRELFSPPLLRTTLLASLLAtGALGGYYGITTWLPSYLTGER----GLSFEGSA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 329 ILSTVFDVGGVLGGISAGFISDKIkARALTSITFLALSIPALIMYrVYGSVSMFINIVLMFISGLLVNGPYALITTAVAA 408
Cdd:cd17371 249 GYLVVTILGGFLGYLAGGFLADRI-GRRNNFALFALGSAISILLY-FFLPLSPTLILILGFPLGFFASGPFSGMGAYLTE 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063700324 409 DLGTqdsikgngRALATVTAIIDGTGSVGAALGPLLAGYISSRG-WNSVFFMLIVSIFFAGLFLV 472
Cdd:cd17371 327 LFPT--------AVRATAQGFCYNVGRIIGALFPFLVGFLATSGsLGTAIAVFAAVYYIAGLVLA 383
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
100-472 |
8.94e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 51.02 E-value: 8.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 100 FAGHLGDRIDLRYFLVFGMMGSGILTLVFGL--GYWMnvhTLGFYMSVQIVCGLFQSIGwpcvvSVVGNWCGKEKRGLIM 177
Cdd:cd17478 50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFapNYWL---LLLLVALAGIGSAAFHPEG-----ARLASQAAGGRRGLAM 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 178 GLWNSHTSVGNILGSVIASSVLDF----GWGWSFVLPGVlvlvsgvvvFMFLVVSPNDLGFEELGKEIEIEMSLGenvee 253
Cdd:cd17478 122 SIFSVGGNLGFALGPLIAAALVALfgglGLLILLIIPGL---------AVALLLLRLRPLKKPEAKKAAAKSSAR----- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 254 SLRKHEAEGAVLLenvddssFAIGFLEAWrlpgvapyafclFFSKLVAYtflywLPYYLRHTAVAGVNlshktAGILSTV 333
Cdd:cd17478 188 STLKGVWRALLLL-------LIIVFLRSW------------VLSSLTTF-----LPFYLVQRGYSLVF-----AGLLLSL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 334 FDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMYRVYGsvsmFINIVLMFISGLLVNGPYALITTAVaadlgtQ 413
Cdd:cd17478 239 FLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPG----IWSYILLVLAGFLLFASFPVTVVLA------Q 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 414 DSIKGNgraLATVTAIIDGTGSVGAALGPLLAGYISSRgWNSVFFMLIVSIF-FAGLFLV 472
Cdd:cd17478 309 ELLPGN---VGLASGLMMGLSFGLGGIGAPVLGALADA-FGLESVLLILALLpLLGALLA 364
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
291-474 |
1.14e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.49 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 291 AFCLFFSKLVAYTFLYWLPYYLRHTavagVNLSHKTAGILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPAL 370
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAED----LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 371 IMYRVYGSVSMfinIVLMFISGLLVNGPYALITTAVAadlgtqDSIKGNGRALAtvTAIIDGTGSVGAALGPLLAGYISS 450
Cdd:pfam07690 78 LLLFASSLWLL---LVLRVLQGLGAGALFPAALALIA------DWFPPEERGRA--LGLVSAGFGLGAALGPLLGGLLAS 146
|
170 180
....*....|....*....|....*
gi 1063700324 451 R-GWNSVFFMLIVSIFFAGLFLVRL 474
Cdd:pfam07690 147 LfGWRAAFLILAILSLLAAVLLLLP 171
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
296-448 |
2.11e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.90 E-value: 2.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 296 FSKLVAYTFLYWLPYYLRHTAVAG-----VNLSHKTAGILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPAL 370
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYyfkyvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063700324 371 IMYrVYGSVSMFINIVLMFISGLLVnGPYALITTAVAADLGTQDSIKGNGRALATVTAIIDGTGSVGAALGPLLAGYI 448
Cdd:COG2211 310 LLF-FLGPGNLWLLLVLAALAGIGL-GAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
89-209 |
2.28e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 49.42 E-value: 2.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 89 AFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLgywmnVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNWC 168
Cdd:COG0477 57 AYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL-----APSPELLIAARALQGIGAGGLMPGALALIAELF 131
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1063700324 169 GKEKRGLIMGLWNSHTSVGNILGSVIASSVLD-FGWGWSFVL 209
Cdd:COG0477 132 PARERGRALGLWGAAIGLGLALGPLLGGLLVAaLGWRWIFLI 173
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
89-442 |
6.27e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 48.40 E-value: 6.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 89 AFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLgywmnVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNWC 168
Cdd:cd17327 49 VFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAA-----VKNFGGLIALRFFLGLFESGVFPGFILYLGMWY 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 169 GKEKRGLIMGLWNSHTSVGNILGSVIASSVLDF-------GWGWSFVLPGVLVLVSGVVVFMFLVVSPNDLGFeeLGKEi 241
Cdd:cd17327 124 KREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKIlgvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWF--LTEE- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 242 EIEMSLgENVEESLRKHEAEGAVLLEnvddssfaigFLEAWRLPGVAPYAFCLFFSKLVAYTFLYWLPYYLRHTAVAGVN 321
Cdd:cd17327 201 EKELAV-ERLRANQTGKGDQKFKWKQ----------IKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQ 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 322 LShktagILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMYrvygsVSMFINIVLMFISGLLVNGPYAl 401
Cdd:cd17327 270 TN-----LLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVGSIIL-----LAAPNPPGAYFAAYILGGGSYA- 338
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1063700324 402 ittAVAADLGTQDSIKGNGRALATVTAIIDGTGSVGAALGP 442
Cdd:cd17327 339 ---GFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAP 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
308-486 |
8.23e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.96 E-value: 8.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 308 LPYYLRHtavagVNLSHKTAGILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIpALIMYRVYGSVSMFinIVL 387
Cdd:cd17325 19 LPLYAES-----LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAV-STLLFAFATSYWQL--LLA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 388 MFISGLLVnGPYALITTAVAADLGTQDSIkgnGRALATVTAIIdgtgSVGAALGPLLAGYISSR-GWNSVFFMLIVSIFF 466
Cdd:cd17325 91 RFLQGLAS-AAVWPAAMALIADIAPPEER---GRAMGIFSSAI----GLGFLIGPLLGGLLADAlGYRAPFLVCAALALL 162
|
170 180
....*....|....*....|
gi 1063700324 467 AGLFLVRLAKSEINTMRSGE 486
Cdd:cd17325 163 ALVLALLLLPEPRPPPNKRA 182
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
293-460 |
1.98e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 46.88 E-value: 1.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 293 CLFFSKLVAYTFLYWLPyylrhTAVAGVNLSHKTAGILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIM 372
Cdd:PRK11551 228 SYFFTLIVLYFLLNWLP-----SLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVVLLIYAGILASLAAL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 373 YRVYGSVSMfinIVLMFISGLLVNGP----YALITTAVAADL-GTqdsikGNGRALAtvtaiidgTGSVGAALGPLLAGY 447
Cdd:PRK11551 303 AAAPSFAGM---LLAGFAAGLFVVGGqsvlYALAPLFYPTQVrGT-----GVGAAVA--------VGRLGSMAGPLLAGQ 366
|
170
....*....|...
gi 1063700324 448 ISSRGWNSVFFML 460
Cdd:PRK11551 367 LLALGRSTVGVIG 379
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
287-472 |
2.45e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 46.41 E-value: 2.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 287 VAPYAFCLFFSKLVAYTFLYWLPYYLRHTAVAgvnlSHKTAGILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALS 366
Cdd:cd17473 199 VLPIYFLAFLAMLLFYVIPIQLPFLLQERGGG----SAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMA 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 367 IPALIMYRVYGSVSMFINIVL-MFISGLLVngPYALITTAVAADLgtqdsiKGNGRALATVTAIIdgtgSVGAALGPLLA 445
Cdd:cd17473 275 LGFLLLALASGLWVVLLGAILaGLGFGLLL--PTLNSWAMSLVPP------ELRGRAMGIVTSAF----FLGQFLSPLVL 342
|
170 180
....*....|....*....|....*..
gi 1063700324 446 GYISSRGWNSVFFMLIVSIFFAGLFLV 472
Cdd:cd17473 343 GPLVNLTGGLSGAFLILGVLALVLAIV 369
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
321-476 |
3.65e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 46.03 E-value: 3.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 321 NLSHKTAGILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMYRVyGSVSMFinIVLMFISGLLVNGPYA 400
Cdd:COG2223 36 GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA-VSYWLL--LLLGLLLGIGGGGSFA 112
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063700324 401 LITTAVAAdlgtqdSIKGNGRALAtvTAIIDGTGSVGAALGPLLAGY-ISSRGWNSVFFMLIVSIFFAGLFLVRLAK 476
Cdd:COG2223 113 VGIALVSK------WFPPDRRGLA--LGLAAGGGNLGAAVAAFLAPLlIAAFGWRNAFLILGILLLVVAVLAWLFLR 181
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
282-474 |
5.39e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.35 E-value: 5.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 282 WRLPGVAPYAFCLFFSKLVAYTFLYWLPYYLRHtavagVNLSHKTAGILSTVFDVGGVLGGISAGFISDKIKARALTSIT 361
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAAD-----LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 362 FLALSIPALIMYrVYGSVSMFinIVLMFISGLLVNGPYALITTAVAadlgtqDSIKGNGRALAtvTAIIDGTGSVGAALG 441
Cdd:COG2814 82 LLLFALGSLLCA-LAPSLWLL--LAARFLQGLGAGALFPAALALIA------DLVPPERRGRA--LGLLGAGLGLGPALG 150
|
170 180 190
....*....|....*....|....*....|....
gi 1063700324 442 PLLAGYISSR-GWNSVFFMLIVSIFFAGLFLVRL 474
Cdd:COG2814 151 PLLGGLLADLfGWRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
94-471 |
8.31e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 44.92 E-value: 8.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 94 YALGMYFAGHLGDRIDLRYFLVFGMMGSGiltLVFGLGYWmnVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNWCGKEKR 173
Cdd:cd17475 44 VAVSMLPAGWLLDRFGERRVLAVGLLLMG---AAALLMAL--VGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRER 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 174 GLIMGLWNSHTSVGNILGSVIASSV-LDFGWGWSFVLPGVLVLVSGVVVFMFLvvspndlgfeelgKEIEIEMSLGENVE 252
Cdd:cd17475 119 GLAMGIRQTGVPLGGALAAALLPPLaLHYGWRAAFVVAGLVSILAAVLFWLFY-------------REPPAASAATESAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 253 ESLRkheaegavllenvddssfaiGFLEAWRLPGVAPYAFCLFFSKLVAYTFL-YWLPYYLRHtavagVNLSHKTAGILS 331
Cdd:cd17475 186 TLLR--------------------SLKEVLRNRDVWLIAIAGALLVAPQFALLtFLLLFLHDH-----LGLSVVAAGALL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 332 TVFDVGGVLGGISAGFISDKIKA---RALTSITFLALSIPALIMYRVYGSVSMFINIVLMFISGLLVNGPYALITTAVAA 408
Cdd:cd17475 241 AVAQLGGALGRIGLGRVSDRVFGgrrRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAE 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063700324 409 DLGTQDSikgnGRALATVTAIIdgtgSVGAALGPLLAGYI--SSRGWNSVFFMLIVSIFFAGLFL 471
Cdd:cd17475 321 SAGPEQA----GTALGLANTIN----FIGIAIGPPLFGLLvdATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
94-474 |
1.29e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.18 E-value: 1.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 94 YALGMYFAGHLGDRIDLRYFLVFG--MMGSGILTLVFGLGYWMnvhtlgFYMSVQIVCGLFQSIGWPCVVSVVGNWCGKE 171
Cdd:cd17355 51 FGLAQPFVGRLLDRFGPRRVMLLGllLLAAGLVLLALATSLWQ------LYLLWGLLGGGGAGTLAAVAFATVAAWWFER 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 172 KRGLIMGLWNSHTSVGNILGSVIASSVLD-FGWGWSFVLPGVLVLVSGVVVFMFLVVSPNDLGfeelgkeieiemslgeN 250
Cdd:cd17355 125 RRGLALGILTAGGGLGSLVFLPLGAALIEaFGWRTALLVLALLALLVLVPVLLLLRRRPADLA----------------L 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 251 VEESLRKHEAEGAVLLENVDDSSFaigfleaWRLpgVAPYAFCLFFSKLVAYTflywLPYYLRHTAvagvnLSHKTAGIL 330
Cdd:cd17355 189 RAYDDASPASPGSTLKEALRSASF-------WLL--ALAFFLCGFAVVGLIVH----LVPYLADRG-----ISPAAAAVA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 331 STVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMYRVYGSVSMFINIVLMFisGLLVNGPYALITTAVAADL 410
Cdd:cd17355 251 LALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALF--GLGWGATVPLTAALAARYF 328
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063700324 411 GtqdsikgnGRALATVTAIIDGTGSVGAALGPLLAGYISSR--GWNSVFFMLIVSIFFAGLFLVRL 474
Cdd:cd17355 329 G--------ARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRtgSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
172-474 |
2.70e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 43.33 E-value: 2.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 172 KRGLIMGLWNSHTSVGNILGSVIASSVLDFGWGWSFVLPGVLVLVSGVVVFMFLVVSPNDlgfeelgkeieiemslgeNV 251
Cdd:cd17474 120 ERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEK------------------AK 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 252 EESLRKHEAEGAVLLENVDDSSFAIGFLeawrlpgvapYAFCLFfsklvayTFLYWLPYYLRHTAvagvnlsHKTAGILS 331
Cdd:cd17474 182 SSSATKLRDLKKALRGRGLLTFLVSAFL----------YFFLYF-------AFLTYLPFLLELLY-------GISPIIIG 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 332 TVFDVGGVLGGISAGFISDKIKARALTS-ITFLALSIPALIMYRVYGSVSMFINIVLMFISGLLVNGPYALITTAVAADL 410
Cdd:cd17474 238 LLFAGWSVLLALGSLFVGRLLKKRFGARrILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELA 317
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063700324 411 GTQdsikgngrALATVTAIIDGTGSVGAALGPLLAGYISSR-GWNSVFFMLIVSIFFAGLFLVRL 474
Cdd:cd17474 318 PEE--------ERGTASSLYNFVRFLGQAVGPLLFGLLLEIfGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
89-452 |
3.08e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 42.93 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 89 AFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLgywmnVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNWC 168
Cdd:cd17321 39 AYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL-----APSLAFLIAARALQGIGAAAIMPASLALIAATF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 169 GKEKRGLIMGLWNSHTSVGNILGSVIASSVLD-FGWGWSFVLpgvlvlvsgvvvfmflvvspndlgfeelgkeieiemsl 247
Cdd:cd17321 114 PGERRGRALGLWGAVVGIGAALGPLLGGLLLElFGWRWIFLI-------------------------------------- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 248 genveeslrkheaegavllenvddsSFAIGFLEAWRLPGVAPYAFCLFFSKLVAYTFLYWLPYYLRHtavaGVNLSHKTA 327
Cdd:cd17321 156 -------------------------NVPIGLVALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQG----VLGYSPLQA 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 328 GILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMYRVYGSVSMFINIVLMFISGLLVNGPYALITTAVA 407
Cdd:cd17321 207 GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAAL 286
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1063700324 408 ADLGTQDSikgngralATVTAIIDGTGSVGAALGPLLAGYISSRG 452
Cdd:cd17321 287 SSVPKEKA--------GAASGILNTARQLGGALGVALLGALLTAG 323
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
88-202 |
3.54e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.97 E-value: 3.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 88 LAFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFglgYWMNVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGN- 166
Cdd:COG2211 271 ALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL---FFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADv 347
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1063700324 167 ------WCGKEKRGLIMGLWNSHTSVGNILGSVIASSVLDFG 202
Cdd:COG2211 348 vdydewKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALF 389
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
321-475 |
4.16e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 42.55 E-value: 4.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 321 NLSHKTAGILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMYRVYGSVSMFInivLMFISGlLVNGPYA 400
Cdd:COG2271 41 GLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLL---LRFLLG-LGEAGFF 116
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063700324 401 LITTAVAADLGTQdsikgngRALATVTAIIDGTGSVGAALGPLLAGYISSR-GWNSVFFMLIVSIFFAGLFLVRLA 475
Cdd:COG2271 117 PAALKLIAEWFPP-------KERGRALGIFNAGGPLGGALAPPLLGWLLAAfGWRAAFLILGLPGLLLALLRFWLL 185
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
90-470 |
5.03e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.21 E-value: 5.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 90 FLSSYALGMYFAGHLGDRIDLRYFLVFG--MMGSGILTLVFGLGYWMnvhtlgFYMSVQIVCGLFQSIGWPCVVSVVGNW 167
Cdd:cd17353 47 TIVFLAISAPFAGRLVDRGGPRKAILIGgiLFGLGFILSAFAISLPL------LFLGYGVLGGIGAGIGYITPVSTAVKW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 168 CgKEKRGLIMGLWNSHTSVGNILGSVIASSVLD-FGWGWSFVLPGVLVLVSGVVVFMFLVVSPNdlgfeelGKEIEIEMS 246
Cdd:cd17353 121 F-PDKRGLATGIVIAGFGLGSLIFSPLIAYLINtVGVPTTFLILGIIFLIIIVIGAFLIRDPPK-------GWVPPGVDP 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 247 LGENVEESLRKHEAEgavllENVDDSSFAIGFLeawrlpgvapyAFCLFFSKLVaYTFLYWLPYylrhtavaGVNLSHKT 326
Cdd:cd17353 193 LANNAENSPRDYTPR-----EMLRTPTFWLLWL-----------MFFLNATAGL-MLIGQAKPI--------GQEFAGLD 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 327 AGILSTVFDVGGVLGGIS---AGFISDKIKARALTSITFLALSIPALIMYRVYGSVSMFinIVLMFISGLLVNGPYALIT 403
Cdd:cd17353 248 AGIAALAVSILSIFNGGGrpfWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLF--VLGVALIGFCYGGGFALFP 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063700324 404 TAVAADLGTQDSIKGNGRALATVtaiidgtgSVGAALGPLLAGYI-SSRGWNSVFFMLIVSIFFAGLF 470
Cdd:cd17353 326 ALTADFFGTKNAGTNYGLLYTAK--------GVGGLIGPIIAAYVlYTGGYNAAFIIAAALSLVALAL 385
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
99-472 |
5.64e-04 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 42.23 E-value: 5.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 99 YFAGHLGDRIDLRY-----FLVFGMMGSGIL--------TLVFGLGYWMNVHTLGFYMSVQIVCGLFQSIGWPCVVSVVG 165
Cdd:cd17313 52 PLVGSLSDRCNSRIgrrrpFILVGAPLAALGlilipnaaDIGLALGDGPRTWALVLFVLGIVLLDFAMNVCQGPVRALLP 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 166 NWCGKEKRGLIMGLWNSHTSVGNILGSVIASSVLDFGW-----GWSFVLPGVLVLVSGVVVFMFLVVSPNDLGFEELGKE 240
Cdd:cd17313 132 DLVPPEQRSKANGIINFMGGLGGVLGYLLGAILWDHNWfgfalGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGE 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 241 IEIEMSLGENVEESLRkheaegavllenvddsSFAIGFLEAWRLPGVAPYAFCLFFSKLVAYT-FLYWLPYYLRHTAVAG 319
Cdd:cd17313 212 HSENPSLGEVLKSLLK----------------LLKIMPRSLLRLLLVIFFWWIAFFPFELFFTdYMGEEVYHGTSAASSH 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 320 VNLSHKTAGILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMY---RVYGSVSMFINIVLMFiSGLLVN 396
Cdd:cd17313 276 YGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMAlvhNVTVALVLFALGGIGW-ATININ 354
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063700324 397 gPYALITtavaadlgtqDSIKGNGRALATVTAIIDGTGSVGAALGPLLAGYISSRGWNSVFFMLIVSIFFAGLFLV 472
Cdd:cd17313 355 -PYPLVS----------DYHSESGRGQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGA 419
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
320-475 |
1.90e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.49 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 320 VNLSHKTAGILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMyrvygsvSMFINIVLMFISGLLVNGPY 399
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF-------AFAPSFWLLLLGRFLLGLGS 98
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063700324 400 ALITTAVAADLGTQdsikGNGRALATVTAIIDGTGSVGAALGPLLAGYISSRGWNSVFFMLIVSIFFAGLFLVRLA 475
Cdd:cd06174 99 GLIDPAVLALIADL----FPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLL 170
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
321-474 |
2.29e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 40.25 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 321 NLSHKTAGILSTVFDVGGVLGGISAGFISDKIKARALTSITFLALSIPALIMYRVYGSVSMfinIVLMFISGLLVNGPYA 400
Cdd:cd17319 34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSL---YVLRFLLGVAEAGFFP 110
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063700324 401 LITTAVAADLGTQDsikgngRALAtvTAIIDGTGSVGAALGPLLAGYI-SSRGWNSVFFML-IVSIFFAGLFLVRL 474
Cdd:cd17319 111 GAIKALAEWFPARE------RGRA--TGLFNSGAPLGAAIGPPLSGWLlLLFGWRWAFIIEgLLGLLLAVLWWFYL 178
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
308-472 |
2.53e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.23 E-value: 2.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 308 LPYYLRHtavagVNLSHKTAGILSTVFDVGGVLGGISAGFISDKI-KARALTSITFLALSIPALIMYRVYGSVSMFiniV 386
Cdd:cd17477 211 LPLYGLR-----LGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFdRRRVLLGCALLGALAALLLPLVPGLPLALL---V 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 387 LMFISGLLVNGPYALITTAVAADLGTQDSIKGNGRALATVtaiidgtgSVGAALGPLLAGYISSRGWNSVFFMLIVSIFF 466
Cdd:cd17477 283 LLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLY--------GLGSVIGPLLAGALMDAFGPHGLFLFLAAVAL 354
|
....*.
gi 1063700324 467 AGLFLV 472
Cdd:cd17477 355 LFLLFL 360
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
88-190 |
2.90e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.96 E-value: 2.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 88 LAFLSSYALGMYFAGHLGDRIDLRYFLVFGMMGSGILTLVFGLgywmnVHTLGFYMSVQIVCGLFQSIGWPCVVSVVGNW 167
Cdd:COG2814 250 ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL-----AGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
90 100
....*....|....*....|...
gi 1063700324 168 CGKEKRGLIMGLWNSHTSVGNIL 190
Cdd:COG2814 325 APPEARGRASGLYNSAFFLGGPL 347
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
90-479 |
3.70e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 39.73 E-value: 3.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 90 FLSSYALGMYF----AGHLGDRIDLRYFLVFGMMGSGILTLVFGLGYwmnvhTLGFymSVQIVCGLFQSIGWPCVVSVVG 165
Cdd:TIGR00894 81 ILSSHFYGQIIiqipVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAA-----GGGI--ALVVFCRVIQGLAQGSVSPATH 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 166 NWCGKEKRGLIMGLWNSHTSVGNILGSVIASSVLDF------GWGWSFVLPGVLVLVSGVVVFMFLVVSPNDLGFEELGK 239
Cdd:TIGR00894 154 KIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWlceswgGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFE 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 240 EIEIEMSLGENVEESLRKHEAEGAVLLENVDDSSFAIgfleawrlpgvapyaFCLFFSKLVAYTFlywLPYYlrHTAVAG 319
Cdd:TIGR00894 234 KKYINSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAI---------------FGHFWLYTILPTY---LPTF--ISWVLR 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 320 VNLshKTAGILSTVFDVGGVLGGISAGFISDKIKARALTS-------ITFLALSIP-ALIMYRVYGSVSMFINIVLMFIS 391
Cdd:TIGR00894 294 VSG--KENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTLSltaarkiFNGIGGLGPgIFAYALPYLSAAFYLTIIILTLA 371
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 392 GLLVNGPYALITTAvAADLGtqdsikgnGRALATVTAIIDGTGSVGAALGPLLAGYISSRG----WNSVFFMLIVSIFFA 467
Cdd:TIGR00894 372 NAVSSGPLAGVLIN-SLDLA--------PRFLGFIKGITGLPGFIGGLIASTLAGNILSQDsknvWLIVFLIMAFVNILC 442
|
410
....*....|..
gi 1063700324 468 GLFLVRLAKSEI 479
Cdd:TIGR00894 443 VIFYLIFGSAER 454
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
283-476 |
6.77e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 38.71 E-value: 6.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 283 RLPGVAPYAFCLFFSKLVAYTFLYWLPYYLRHTAVAGVNLSHKTAGILSTVFDVGGVLGGISAGFISDKIKARALTSITF 362
Cdd:cd17504 175 RRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGL 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063700324 363 LALSIPALIMyrVYGSVSMFINIVLMFISGLLVNGPYALITTAVAADLGTQDSikgngralATVTAIIDGTGSVGAALGP 442
Cdd:cd17504 255 VISAVGLLLL--ALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRT--------GIATGMNTVLRTIGSAIGP 324
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1063700324 443 LLAGYI-------------SSRGWNSVFFMLIVSIFFAGLFLVRLAK 476
Cdd:cd17504 325 AIAGAIlttytvsitsggvPTEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| |
