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Conserved domains on  [gi|1061899908|ref|NP_001317947|]
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vacuolar protein sorting-associated protein 26C isoform 2 [Homo sapiens]

Protein Classification

vacuolar protein sorting-associated family 26 protein( domain architecture ID 367054)

vacuolar protein sorting-associated family 26 (Vps26) protein similar to Dictyostelium discoideum vacuolar protein sorting-associated protein 26C that may act as component of the retriever complex

CATH:  2.60.40.640
Gene Ontology:  GO:0006886
SCOP:  4004065

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arrestin_N super family cl22903
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 31-158 7.71e-41

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


The actual alignment was detected with superfamily member pfam03643:

Pssm-ID: 451447 [Multi-domain]  Cd Length: 275  Bit Score: 138.34  E-value: 7.71e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899908  31 DFTITPETLQNVKERAL------------LPKFllrgHLNSTncvitqpLTGELVVESSEAAIRSVELQLVRVETCGCAE 98
Cdd:pfam03643 145 NFTTYPETNNSIKMEVGiedclhiefeynKSKY----HLKDV-------IVGKIYFLLVRIKIKHMELQLIRRESTGTGP 213

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1061899908  99 GYARDATEIQNIQIADGDVCRGLSVPIYMVFPRLFTCPTLETTN--FKVEFEVNIVVLLHPD 158
Cdd:pfam03643 214 NTFTESETIAKFEIMDGAPVRGESIPIRLFLAGYDLTPTMRDVNkkFSVKYFLNLVLVDEED 275
 
Name Accession Description Interval E-value
Vps26 pfam03643
Vacuolar protein sorting-associated protein 26; Vacuolar protein sorting-associated protein ...
 31-158 7.71e-41

Vacuolar protein sorting-associated protein 26; Vacuolar protein sorting-associated protein (Vps) 26 is one of around 50 proteins involved in protein trafficking. In particular, Vps26 assembles into a retromer complex with at least four other proteins Vps5, Vps17, Vps29 and Vps35. This family also contains Down syndrome critical region 3/A.


Pssm-ID: 397622 [Multi-domain]  Cd Length: 275  Bit Score: 138.34  E-value: 7.71e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899908  31 DFTITPETLQNVKERAL------------LPKFllrgHLNSTncvitqpLTGELVVESSEAAIRSVELQLVRVETCGCAE 98
Cdd:pfam03643 145 NFTTYPETNNSIKMEVGiedclhiefeynKSKY----HLKDV-------IVGKIYFLLVRIKIKHMELQLIRRESTGTGP 213

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1061899908  99 GYARDATEIQNIQIADGDVCRGLSVPIYMVFPRLFTCPTLETTN--FKVEFEVNIVVLLHPD 158
Cdd:pfam03643 214 NTFTESETIAKFEIMDGAPVRGESIPIRLFLAGYDLTPTMRDVNkkFSVKYFLNLVLVDEED 275
 
Name Accession Description Interval E-value
Vps26 pfam03643
Vacuolar protein sorting-associated protein 26; Vacuolar protein sorting-associated protein ...
 31-158 7.71e-41

Vacuolar protein sorting-associated protein 26; Vacuolar protein sorting-associated protein (Vps) 26 is one of around 50 proteins involved in protein trafficking. In particular, Vps26 assembles into a retromer complex with at least four other proteins Vps5, Vps17, Vps29 and Vps35. This family also contains Down syndrome critical region 3/A.


Pssm-ID: 397622 [Multi-domain]  Cd Length: 275  Bit Score: 138.34  E-value: 7.71e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899908  31 DFTITPETLQNVKERAL------------LPKFllrgHLNSTncvitqpLTGELVVESSEAAIRSVELQLVRVETCGCAE 98
Cdd:pfam03643 145 NFTTYPETNNSIKMEVGiedclhiefeynKSKY----HLKDV-------IVGKIYFLLVRIKIKHMELQLIRRESTGTGP 213

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1061899908  99 GYARDATEIQNIQIADGDVCRGLSVPIYMVFPRLFTCPTLETTN--FKVEFEVNIVVLLHPD 158
Cdd:pfam03643 214 NTFTESETIAKFEIMDGAPVRGESIPIRLFLAGYDLTPTMRDVNkkFSVKYFLNLVLVDEED 275
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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