A-kinase anchor protein inhibitor 1 isoform 2 [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| AKAP7_RIRII_bdg super family | cl11112 | PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ... |
19-51 | 3.26e-03 | ||
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal. The actual alignment was detected with superfamily member pfam10470: Pssm-ID: 463101 Cd Length: 56 Bit Score: 32.24 E-value: 3.26e-03
|
||||||
| Name | Accession | Description | Interval | E-value | ||
| AKAP7_RIRII_bdg | pfam10470 | PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ... |
19-51 | 3.26e-03 | ||
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal. Pssm-ID: 463101 Cd Length: 56 Bit Score: 32.24 E-value: 3.26e-03
|
||||||
| Name | Accession | Description | Interval | E-value | ||
| AKAP7_RIRII_bdg | pfam10470 | PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the ... |
19-51 | 3.26e-03 | ||
PKA-RI-RII subunit binding domain of A-kinase anchor protein; AKAP7_RIRII_bdg is the C-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA, for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes, by binding to its regulatory subunits, RI and RII, hence being known as a dual-specific AKAP. The 25 crucial amino acids of RII-binding domains in general form structurally conserved amphipathic helices with unrelated sequences; hydrophobic amino acid residues form the backbone of the interaction and hydrogen bond- and salt-bridge-forming amino acid residues increase the affinity of the interaction. The N-terminus, of family AKAP7_NLS, carries the nuclear localization signal. Pssm-ID: 463101 Cd Length: 56 Bit Score: 32.24 E-value: 3.26e-03
|
||||||
| Blast search parameters | ||||
|
