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histone deacetylase complex subunit SAP130 isoform g [Homo sapiens]
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
635-1005
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 578.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 635 A Q GSSPRPSILRKKPAT D GAKPK SE IHV SM A T PVTV SM E TVSN QN ND Q P T IAVP P TA Q Q P PPT IPT MI A A A S PPSQP A V A 714
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E GAKPK PD IHV AV A P PVTV AV E ALPG QN SE Q Q T ASAS P PS Q H P AQA IPT IL A P A A PPSQP S V V 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 715 LST I P G A VPI TPPI T --- TIAA APP PSVTVGGSLSSVLGPPV PEIK V K E E V EPMD IMR pvs A VPPL ATNTV SP S L AL LAN 791
Cdd:pfam16014 81 LST L P A A MAV TPPI P asm ANVV APP TQPAASSTAACAVSSVL PEIK I K Q E A EPMD TSQ --- S VPPL TPTSI SP A L TS LAN 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 792 NLS M P TS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS TA K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPI 871
Cdd:pfam16014 158 NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS AP K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPI 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 872 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S CRAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I I 951
Cdd:pfam16014 238 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T CRAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L I 317
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1057866008 952 PKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLDHKDRVLKLLN 1005
Cdd:pfam16014 318 PKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLDHKDRVLKLLN 371
PHA03247 super family
cl33720 large tegument protein UL36; Provisional
347-851
9.52e-06
large tegument protein UL36; Provisional
PHA03247 :Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.94
E-value: 9.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 347 T P VAAATVA P ILATNTI P SATT A GSV S HTQAPTSTIVTMTV P SHSSHATA V TTSNI P VAKVV P QQITHTSPRIQ P DY P AE 426
Cdd:PHA03247 2552 P P PLPPAAP P AAPDRSV P PPRP A PRP S EPAVTSRARRPDAP P QSARPRAP V DDRGD P RGPAP P SPLPPDTHAPD P PP P SP 2631
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 427 RSSLIPISG H RASPN P VAMET R S D NR P S ------- VPVQFQYFLPTY PP SAY -- PL A AH T YTPI TS SVSTIRQY P VSAQ A 497
Cdd:PHA03247 2632 SPAANEPDP H PPPTV P PPERP R D D PA P G rvsrprr ARRLGRAAQASS PP QRP rr RA A RP T VGSL TS LADPPPPP P TPEP A 2711
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 498 P NSAIT A qtgvgvast VH L N P MQLMTVD AS H A RHIQGIQ PA PIST qgiq PA PI G T P GIQPA P LG T Q G IHSAT P INTQGLQ 577
Cdd:PHA03247 2712 P HALVS A --------- TP L P P GPAAARQ AS P A LPAAPAP PA VPAG ---- PA TP G G P ARPAR P PT T A G PPAPA P PAAPAAG 2778
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 578 P APMG T QQ ------------ P Q P EGKTSAVVLADGATIVAN P ISN P FSAA P AA T TVVQ T HSQ ----- SASTNAPAQGSS P 640
Cdd:PHA03247 2779 P PRRL T RP avaslsesresl P S P WDPADPPAAVLAPAAALP P AAS P AGPL P PP T SAQP T APP pppgp PPPSLPLGGSVA P 2858
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 641 RPSIL R KK P A - TDG AKP KSEIHV --- SM A T P VT vsme TV S NQNNDQ P TIAVPPTA Q QPP P TI P TMIAAAS PP S QP AVALS 716
Cdd:PHA03247 2859 GGDVR R RP P S r SPA AKP AAPARP pvr RL A R P AV ---- SR S TESFAL P PDQPERPP Q PQA P PP P QPQPQPP PP P QP QPPPP 2934
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 717 TI P GAV P ITP P I T TI A A A PP PS VT V GGSLSSV L G P --- P VP EIK V KEEVEPMDI mr P V S AV PPL a T NTVSPSLALL A NN L 793
Cdd:PHA03247 2935 PP P RPQ P PLA P T T DP A G A GE PS GA V PQPWLGA L V P grv A VP RFR V PQPAPSREA -- P A S ST PPL - T GHSLSRVSSW A SS L 3011
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 794 SMPTSDL PP GA S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S TAKS L LVKAEKRKS P P 851
Cdd:PHA03247 3012 ALHEETD PP PV S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P F 3066
PHA03247 super family
cl33720 large tegument protein UL36; Provisional
19-339
1.79e-05
large tegument protein UL36; Provisional
PHA03247 :Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.17
E-value: 1.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 19 A PS QIANSGSAGLIN P AATVND E SG RD SEVSA R EHMSSSSSLQS R EEKQEPVVV RP YPQVQMLSTHHAVAS A T P VAVTAP 98
Cdd:PHA03247 2628 P PS PSPAANEPDPHP P PTVPPP E RP RD DPAPG R VSRPRRARRLG R AAQASSPPQ RP RRRAARPTVGSLTSL A D P PPPPPT 2707
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 99 P AHLTP A VPLSFSEGLMKPPPKPTM P SR P I APAPP STLS l P P KV PG QVTVTMESSIPQASAI P VATISGQQ G H P SN L HHI 178
Cdd:PHA03247 2708 P EPAPH A LVSATPLPPGPAAARQAS P AL P A APAPP AVPA - G P AT PG GPARPARPPTTAGPPA P APPAAPAA G P P RR L TRP 2786
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 179 MTTNVQM S IIRSNA P GP P LHIG A SH L PR gaaaaavms SSKVTTVLR P TSQ LP NAAT AQP AVQHIIHQ P IQ sr P PVTTSNA 258
Cdd:PHA03247 2787 AVASLSE S RESLPS P WD P ADPP A AV L AP --------- AAALPPAAS P AGP LP PPTS AQP TAPPPPPG P PP -- P SLPLGGS 2855
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 259 IP P AVVATVSATRAQSPVITTTA A HATDSA L S RP TL S IQHPPS A -- AISIQ RP A Q SRDVTTRITL P SH P ALGT P KQQLHT 336
Cdd:PHA03247 2856 VA P GGDVRRRPPSRSPAAKPAAP A RPPVRR L A RP AV S RSTESF A lp PDQPE RP P Q PQAPPPPQPQ P QP P PPPQ P QPPPPP 2935
...
gi 1057866008 337 MAQ 339
Cdd:PHA03247 2936 PPR 2938
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
635-1005
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 578.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 635 A Q GSSPRPSILRKKPAT D GAKPK SE IHV SM A T PVTV SM E TVSN QN ND Q P T IAVP P TA Q Q P PPT IPT MI A A A S PPSQP A V A 714
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E GAKPK PD IHV AV A P PVTV AV E ALPG QN SE Q Q T ASAS P PS Q H P AQA IPT IL A P A A PPSQP S V V 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 715 LST I P G A VPI TPPI T --- TIAA APP PSVTVGGSLSSVLGPPV PEIK V K E E V EPMD IMR pvs A VPPL ATNTV SP S L AL LAN 791
Cdd:pfam16014 81 LST L P A A MAV TPPI P asm ANVV APP TQPAASSTAACAVSSVL PEIK I K Q E A EPMD TSQ --- S VPPL TPTSI SP A L TS LAN 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 792 NLS M P TS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS TA K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPI 871
Cdd:pfam16014 158 NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS AP K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPI 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 872 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S CRAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I I 951
Cdd:pfam16014 238 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T CRAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L I 317
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1057866008 952 PKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLDHKDRVLKLLN 1005
Cdd:pfam16014 318 PKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLDHKDRVLKLLN 371
PHA03247
PHA03247 large tegument protein UL36; Provisional
347-851
9.52e-06
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.94
E-value: 9.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 347 T P VAAATVA P ILATNTI P SATT A GSV S HTQAPTSTIVTMTV P SHSSHATA V TTSNI P VAKVV P QQITHTSPRIQ P DY P AE 426
Cdd:PHA03247 2552 P P PLPPAAP P AAPDRSV P PPRP A PRP S EPAVTSRARRPDAP P QSARPRAP V DDRGD P RGPAP P SPLPPDTHAPD P PP P SP 2631
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 427 RSSLIPISG H RASPN P VAMET R S D NR P S ------- VPVQFQYFLPTY PP SAY -- PL A AH T YTPI TS SVSTIRQY P VSAQ A 497
Cdd:PHA03247 2632 SPAANEPDP H PPPTV P PPERP R D D PA P G rvsrprr ARRLGRAAQASS PP QRP rr RA A RP T VGSL TS LADPPPPP P TPEP A 2711
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 498 P NSAIT A qtgvgvast VH L N P MQLMTVD AS H A RHIQGIQ PA PIST qgiq PA PI G T P GIQPA P LG T Q G IHSAT P INTQGLQ 577
Cdd:PHA03247 2712 P HALVS A --------- TP L P P GPAAARQ AS P A LPAAPAP PA VPAG ---- PA TP G G P ARPAR P PT T A G PPAPA P PAAPAAG 2778
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 578 P APMG T QQ ------------ P Q P EGKTSAVVLADGATIVAN P ISN P FSAA P AA T TVVQ T HSQ ----- SASTNAPAQGSS P 640
Cdd:PHA03247 2779 P PRRL T RP avaslsesresl P S P WDPADPPAAVLAPAAALP P AAS P AGPL P PP T SAQP T APP pppgp PPPSLPLGGSVA P 2858
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 641 RPSIL R KK P A - TDG AKP KSEIHV --- SM A T P VT vsme TV S NQNNDQ P TIAVPPTA Q QPP P TI P TMIAAAS PP S QP AVALS 716
Cdd:PHA03247 2859 GGDVR R RP P S r SPA AKP AAPARP pvr RL A R P AV ---- SR S TESFAL P PDQPERPP Q PQA P PP P QPQPQPP PP P QP QPPPP 2934
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 717 TI P GAV P ITP P I T TI A A A PP PS VT V GGSLSSV L G P --- P VP EIK V KEEVEPMDI mr P V S AV PPL a T NTVSPSLALL A NN L 793
Cdd:PHA03247 2935 PP P RPQ P PLA P T T DP A G A GE PS GA V PQPWLGA L V P grv A VP RFR V PQPAPSREA -- P A S ST PPL - T GHSLSRVSSW A SS L 3011
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 794 SMPTSDL PP GA S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S TAKS L LVKAEKRKS P P 851
Cdd:PHA03247 3012 ALHEETD PP PV S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P F 3066
PHA03247
PHA03247 large tegument protein UL36; Provisional
19-339
1.79e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.17
E-value: 1.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 19 A PS QIANSGSAGLIN P AATVND E SG RD SEVSA R EHMSSSSSLQS R EEKQEPVVV RP YPQVQMLSTHHAVAS A T P VAVTAP 98
Cdd:PHA03247 2628 P PS PSPAANEPDPHP P PTVPPP E RP RD DPAPG R VSRPRRARRLG R AAQASSPPQ RP RRRAARPTVGSLTSL A D P PPPPPT 2707
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 99 P AHLTP A VPLSFSEGLMKPPPKPTM P SR P I APAPP STLS l P P KV PG QVTVTMESSIPQASAI P VATISGQQ G H P SN L HHI 178
Cdd:PHA03247 2708 P EPAPH A LVSATPLPPGPAAARQAS P AL P A APAPP AVPA - G P AT PG GPARPARPPTTAGPPA P APPAAPAA G P P RR L TRP 2786
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 179 MTTNVQM S IIRSNA P GP P LHIG A SH L PR gaaaaavms SSKVTTVLR P TSQ LP NAAT AQP AVQHIIHQ P IQ sr P PVTTSNA 258
Cdd:PHA03247 2787 AVASLSE S RESLPS P WD P ADPP A AV L AP --------- AAALPPAAS P AGP LP PPTS AQP TAPPPPPG P PP -- P SLPLGGS 2855
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 259 IP P AVVATVSATRAQSPVITTTA A HATDSA L S RP TL S IQHPPS A -- AISIQ RP A Q SRDVTTRITL P SH P ALGT P KQQLHT 336
Cdd:PHA03247 2856 VA P GGDVRRRPPSRSPAAKPAAP A RPPVRR L A RP AV S RSTESF A lp PDQPE RP P Q PQAPPPPQPQ P QP P PPPQ P QPPPPP 2935
...
gi 1057866008 337 MAQ 339
Cdd:PHA03247 2936 PPR 2938
Atrophin-1
pfam03154 Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
410-786
3.73e-04
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain]
Cd Length: 991
Bit Score: 44.76
E-value: 3.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 410 QQI TH T S P riq P DYP A ERSSLI P I S GHRASPNPV A METRSDNR PSVP V Q FQ yf LP T YP P SAYPLA ah T YT P I T SSVS T IR 489
Cdd:pfam03154 164 QQI LQ T Q P --- P VLQ A QSGAAS P P S PPPPGTTQA A TAGPTPSA PSVP P Q GS -- PA T SQ P PNQTQS -- T AA P H T LIQQ T PT 236
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 490 QY P VSAQA P NSAITAQ T GVGVA S T V HLN P MQL ------------- MTVDA SH AR H IQGI QP A P IST Q GI Q PA pi GT PG IQ 556
Cdd:pfam03154 237 LH P QRLPS P HPPLQPM T QPPPP S Q V SPQ P LPQ pslhgqmppmphs LQTGP SH MQ H PVPP QP F P LTP Q SS Q SQ -- VP PG PS 314
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 557 PA PL G TQGIHSA TP INTQG LQ PAPMGTQ QP Q P EGKT S AVVLADGA T IVANPIS NP F S AAPAATTVVQTHS Q SA S TNA P AQ 636
Cdd:pfam03154 315 PA AP G QSQQRIH TP PSQSQ LQ SQQPPRE QP L P PAPL S MPHIKPPP T TPIPQLP NP Q S HKHPPHLSGPSPF Q MN S NLP P PP 394
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 637 GSS P RP S ILRKK P ATDGAK P KSEIHV S MAT P VTVSMET V SN Q NNDQ P TI A VPPTAQQPPPTI P TMIAAASP P SQ P AVALS 716
Cdd:pfam03154 395 ALK P LS S LSTHH P PSAHPP P LQLMPQ S QQL P PPPAQPP V LT Q SQSL P PP A ASHPPTSGLHQV P SQSPFPQH P FV P GGPPP 474
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1057866008 717 TI P GAV P I T PPITTIAAAP PP --- SV TVG G SLSSVLGP P V P EIKV KEE v EPMDIMR P V S AV PP LATNTVS P SL 786
Cdd:pfam03154 475 IT P PSG P P T STSSAMPGIQ PP ssa SV SSS G PVPAAVSC P L P PVQI KEE - ALDEAEE P E S PP PP PRSPSPE P TV 546
PRK07003
PRK07003 DNA polymerase III subunit gamma/tau;
579-814
3.64e-03
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain]
Cd Length: 830
Bit Score: 41.37
E-value: 3.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 579 AP M G TQQPQPE G K -- TSAVVL A DGATIV A N P ISNPFSA A PA A TTVVQTHSQS A S T N A P A QGSS P R P SILRKKPATDGAKP 656
Cdd:PRK07003 367 AP G G GVPARVA G A vp APGARA A AAVGAS A V P AVTAVTG A AG A ALAPKAAAAA A A T R A E A PPAA P A P PATADRGDDAADGD 446
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 657 KS eih V SMATPVTV S METVSNQNND QP TIA vpptaqqpppti PTMIA A ASPPSQ P AV A LSTI P G A VPITPPITTIAAAP - 735
Cdd:PRK07003 447 AP --- V PAKANARA S ADSRCDERDA QP PAD ------------ SGSAS A PASDAP P DA A FEPA P R A AAPSAATPAAVPDA r 511
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1057866008 736 P P SVTVGGSLSSVLG PP V PE IKVKE evepmdimr P VS A V P PLATNTVSPS L AL L A N NLSMPT SD LPPG A SPRK KP RKQQ 814
Cdd:PRK07003 512 A P AAASREDAPAAAA PP A PE ARPPT --------- P AA A A P AARAGGAAAA L DV L R N AGMRVS SD RGAR A AAAA KP AAAP 581
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
635-1005
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 578.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 635 A Q GSSPRPSILRKKPAT D GAKPK SE IHV SM A T PVTV SM E TVSN QN ND Q P T IAVP P TA Q Q P PPT IPT MI A A A S PPSQP A V A 714
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E GAKPK PD IHV AV A P PVTV AV E ALPG QN SE Q Q T ASAS P PS Q H P AQA IPT IL A P A A PPSQP S V V 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 715 LST I P G A VPI TPPI T --- TIAA APP PSVTVGGSLSSVLGPPV PEIK V K E E V EPMD IMR pvs A VPPL ATNTV SP S L AL LAN 791
Cdd:pfam16014 81 LST L P A A MAV TPPI P asm ANVV APP TQPAASSTAACAVSSVL PEIK I K Q E A EPMD TSQ --- S VPPL TPTSI SP A L TS LAN 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 792 NLS M P TS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS TA K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPI 871
Cdd:pfam16014 158 NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS AP K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPI 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 872 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S CRAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I I 951
Cdd:pfam16014 238 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T CRAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L I 317
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1057866008 952 PKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLDHKDRVLKLLN 1005
Cdd:pfam16014 318 PKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLDHKDRVLKLLN 371
PHA03247
PHA03247 large tegument protein UL36; Provisional
347-851
9.52e-06
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.94
E-value: 9.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 347 T P VAAATVA P ILATNTI P SATT A GSV S HTQAPTSTIVTMTV P SHSSHATA V TTSNI P VAKVV P QQITHTSPRIQ P DY P AE 426
Cdd:PHA03247 2552 P P PLPPAAP P AAPDRSV P PPRP A PRP S EPAVTSRARRPDAP P QSARPRAP V DDRGD P RGPAP P SPLPPDTHAPD P PP P SP 2631
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 427 RSSLIPISG H RASPN P VAMET R S D NR P S ------- VPVQFQYFLPTY PP SAY -- PL A AH T YTPI TS SVSTIRQY P VSAQ A 497
Cdd:PHA03247 2632 SPAANEPDP H PPPTV P PPERP R D D PA P G rvsrprr ARRLGRAAQASS PP QRP rr RA A RP T VGSL TS LADPPPPP P TPEP A 2711
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 498 P NSAIT A qtgvgvast VH L N P MQLMTVD AS H A RHIQGIQ PA PIST qgiq PA PI G T P GIQPA P LG T Q G IHSAT P INTQGLQ 577
Cdd:PHA03247 2712 P HALVS A --------- TP L P P GPAAARQ AS P A LPAAPAP PA VPAG ---- PA TP G G P ARPAR P PT T A G PPAPA P PAAPAAG 2778
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 578 P APMG T QQ ------------ P Q P EGKTSAVVLADGATIVAN P ISN P FSAA P AA T TVVQ T HSQ ----- SASTNAPAQGSS P 640
Cdd:PHA03247 2779 P PRRL T RP avaslsesresl P S P WDPADPPAAVLAPAAALP P AAS P AGPL P PP T SAQP T APP pppgp PPPSLPLGGSVA P 2858
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 641 RPSIL R KK P A - TDG AKP KSEIHV --- SM A T P VT vsme TV S NQNNDQ P TIAVPPTA Q QPP P TI P TMIAAAS PP S QP AVALS 716
Cdd:PHA03247 2859 GGDVR R RP P S r SPA AKP AAPARP pvr RL A R P AV ---- SR S TESFAL P PDQPERPP Q PQA P PP P QPQPQPP PP P QP QPPPP 2934
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 717 TI P GAV P ITP P I T TI A A A PP PS VT V GGSLSSV L G P --- P VP EIK V KEEVEPMDI mr P V S AV PPL a T NTVSPSLALL A NN L 793
Cdd:PHA03247 2935 PP P RPQ P PLA P T T DP A G A GE PS GA V PQPWLGA L V P grv A VP RFR V PQPAPSREA -- P A S ST PPL - T GHSLSRVSSW A SS L 3011
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 794 SMPTSDL PP GA S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S TAKS L LVKAEKRKS P P 851
Cdd:PHA03247 3012 ALHEETD PP PV S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P F 3066
PHA03247
PHA03247 large tegument protein UL36; Provisional
19-339
1.79e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.17
E-value: 1.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 19 A PS QIANSGSAGLIN P AATVND E SG RD SEVSA R EHMSSSSSLQS R EEKQEPVVV RP YPQVQMLSTHHAVAS A T P VAVTAP 98
Cdd:PHA03247 2628 P PS PSPAANEPDPHP P PTVPPP E RP RD DPAPG R VSRPRRARRLG R AAQASSPPQ RP RRRAARPTVGSLTSL A D P PPPPPT 2707
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 99 P AHLTP A VPLSFSEGLMKPPPKPTM P SR P I APAPP STLS l P P KV PG QVTVTMESSIPQASAI P VATISGQQ G H P SN L HHI 178
Cdd:PHA03247 2708 P EPAPH A LVSATPLPPGPAAARQAS P AL P A APAPP AVPA - G P AT PG GPARPARPPTTAGPPA P APPAAPAA G P P RR L TRP 2786
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 179 MTTNVQM S IIRSNA P GP P LHIG A SH L PR gaaaaavms SSKVTTVLR P TSQ LP NAAT AQP AVQHIIHQ P IQ sr P PVTTSNA 258
Cdd:PHA03247 2787 AVASLSE S RESLPS P WD P ADPP A AV L AP --------- AAALPPAAS P AGP LP PPTS AQP TAPPPPPG P PP -- P SLPLGGS 2855
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 259 IP P AVVATVSATRAQSPVITTTA A HATDSA L S RP TL S IQHPPS A -- AISIQ RP A Q SRDVTTRITL P SH P ALGT P KQQLHT 336
Cdd:PHA03247 2856 VA P GGDVRRRPPSRSPAAKPAAP A RPPVRR L A RP AV S RSTESF A lp PDQPE RP P Q PQAPPPPQPQ P QP P PPPQ P QPPPPP 2935
...
gi 1057866008 337 MAQ 339
Cdd:PHA03247 2936 PPR 2938
PHA03247
PHA03247 large tegument protein UL36; Provisional
98-492
8.11e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 46.86
E-value: 8.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 98 PP AH L T PA --------- VP LSFSEGLMKP P PKPTMPS RP I AP APPSTLSL P PKVP G QVTVTMES S - I P QASAI P VATISG 167
Cdd:PHA03247 2551 PP PP L P PA appaapdrs VP PPRPAPRPSE P AVTSRAR RP D AP PQSARPRA P VDDR G DPRGPAPP S p L P PDTHA P DPPPPS 2630
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 168 QQGHPSNLHHIMTTN V QMSIIRSNA P G P P ------------ LHIG AS HL P RGAAAA A VMSS - SKV T TVLR P TSQL P NAAT 234
Cdd:PHA03247 2631 PSPAANEPDPHPPPT V PPPERPRDD P A P G rvsrprrarrlg RAAQ AS SP P QRPRRR A ARPT v GSL T SLAD P PPPP P TPEP 2710
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 235 A QP A VQHIIHQ P IQSRPPVTT S N A I P P A VVATVSATRAQS P V - ITTT A AHA T DSALSR P TLSIQHPPSAAISIQ RPA QSR 313
Cdd:PHA03247 2711 A PH A LVSATPL P PGPAAARQA S P A L P A A PAPPAVPAGPAT P G g PARP A RPP T TAGPPA P APPAAPAAGPPRRLT RPA VAS 2790
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 314 DVTT R IT LPS ------ H PA LGTPKQQLHTM A QKTIFSTGT P VA A ATV AP ILATNTI P SATTA G SVSHTQAP tsti V TMTV 387
Cdd:PHA03247 2791 LSES R ES LPS pwdpad P PA AVLAPAAALPP A ASPAGPLPP P TS A QPT AP PPPPGPP P PSLPL G GSVAPGGD ---- V RRRP 2866
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 388 PS H S SH A TAVTTSNI PV AKV vpqqithts P R IQPDYPA E RSS L I P ISGH R ASPNPVAMETRSDNR P SV P V Q F Q YFL P TY P 467
Cdd:PHA03247 2867 PS R S PA A KPAAPARP PV RRL --------- A R PAVSRST E SFA L P P DQPE R PPQPQAPPPPQPQPQ P PP P P Q P Q PPP P PP P 2937
410 420
....*....|....*....|....*
gi 1057866008 468 PSAY PLA AH T YTPITSSV S TIRQY P 492
Cdd:PHA03247 2938 RPQP PLA PT T DPAGAGEP S GAVPQ P 2962
Atrophin-1
pfam03154 Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
410-786
3.73e-04
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain]
Cd Length: 991
Bit Score: 44.76
E-value: 3.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 410 QQI TH T S P riq P DYP A ERSSLI P I S GHRASPNPV A METRSDNR PSVP V Q FQ yf LP T YP P SAYPLA ah T YT P I T SSVS T IR 489
Cdd:pfam03154 164 QQI LQ T Q P --- P VLQ A QSGAAS P P S PPPPGTTQA A TAGPTPSA PSVP P Q GS -- PA T SQ P PNQTQS -- T AA P H T LIQQ T PT 236
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 490 QY P VSAQA P NSAITAQ T GVGVA S T V HLN P MQL ------------- MTVDA SH AR H IQGI QP A P IST Q GI Q PA pi GT PG IQ 556
Cdd:pfam03154 237 LH P QRLPS P HPPLQPM T QPPPP S Q V SPQ P LPQ pslhgqmppmphs LQTGP SH MQ H PVPP QP F P LTP Q SS Q SQ -- VP PG PS 314
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 557 PA PL G TQGIHSA TP INTQG LQ PAPMGTQ QP Q P EGKT S AVVLADGA T IVANPIS NP F S AAPAATTVVQTHS Q SA S TNA P AQ 636
Cdd:pfam03154 315 PA AP G QSQQRIH TP PSQSQ LQ SQQPPRE QP L P PAPL S MPHIKPPP T TPIPQLP NP Q S HKHPPHLSGPSPF Q MN S NLP P PP 394
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 637 GSS P RP S ILRKK P ATDGAK P KSEIHV S MAT P VTVSMET V SN Q NNDQ P TI A VPPTAQQPPPTI P TMIAAASP P SQ P AVALS 716
Cdd:pfam03154 395 ALK P LS S LSTHH P PSAHPP P LQLMPQ S QQL P PPPAQPP V LT Q SQSL P PP A ASHPPTSGLHQV P SQSPFPQH P FV P GGPPP 474
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1057866008 717 TI P GAV P I T PPITTIAAAP PP --- SV TVG G SLSSVLGP P V P EIKV KEE v EPMDIMR P V S AV PP LATNTVS P SL 786
Cdd:pfam03154 475 IT P PSG P P T STSSAMPGIQ PP ssa SV SSS G PVPAAVSC P L P PVQI KEE - ALDEAEE P E S PP PP PRSPSPE P TV 546
PRK07003
PRK07003 DNA polymerase III subunit gamma/tau;
579-814
3.64e-03
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain]
Cd Length: 830
Bit Score: 41.37
E-value: 3.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 579 AP M G TQQPQPE G K -- TSAVVL A DGATIV A N P ISNPFSA A PA A TTVVQTHSQS A S T N A P A QGSS P R P SILRKKPATDGAKP 656
Cdd:PRK07003 367 AP G G GVPARVA G A vp APGARA A AAVGAS A V P AVTAVTG A AG A ALAPKAAAAA A A T R A E A PPAA P A P PATADRGDDAADGD 446
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 657 KS eih V SMATPVTV S METVSNQNND QP TIA vpptaqqpppti PTMIA A ASPPSQ P AV A LSTI P G A VPITPPITTIAAAP - 735
Cdd:PRK07003 447 AP --- V PAKANARA S ADSRCDERDA QP PAD ------------ SGSAS A PASDAP P DA A FEPA P R A AAPSAATPAAVPDA r 511
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1057866008 736 P P SVTVGGSLSSVLG PP V PE IKVKE evepmdimr P VS A V P PLATNTVSPS L AL L A N NLSMPT SD LPPG A SPRK KP RKQQ 814
Cdd:PRK07003 512 A P AAASREDAPAAAA PP A PE ARPPT --------- P AA A A P AARAGGAAAA L DV L R N AGMRVS SD RGAR A AAAA KP AAAP 581
PRK07764
PRK07764 DNA polymerase III subunits gamma and tau; Validated
250-643
3.76e-03
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain]
Cd Length: 824
Bit Score: 41.12
E-value: 3.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 250 R PPVTTSN A IP PA VV A TVS A TR A QSPV i TTT AA H A TDS A LSRPTLSIQH P PS A AISIQR P AQSRDVTTRITL PS H P ALGT 329
Cdd:PRK07764 383 R RLGVAGG A GA PA AA A PSA A AA A PAAA - PAP AA A A PAA A AAPAPAAAPQ P AP A PAPAPA P PSPAGNAPAGGA PS P P PAAA 461
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 330 P KQ Q LHTMAQKTIFS T GT P VA A ATV AP il A TNTI P S A TT A GSVSHTQAPTS T I ------ VTMT VP SH S SHAT A VTTSNIP 403
Cdd:PRK07764 462 P SA Q PAPAPAAAPEP T AA P AP A PPA AP -- A PAAA P A A PA A PAAPAGADDAA T L rerwpe ILAA VP KR S RKTW A ILLPEAT 539
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 404 V AK V VPQQ -- ITHTSP ---- R I - Q P DYPAE - RSS L IPIS G HRASPNP V AMETRSDNRPSV P VQFQYFL P TYP --- P S A YP 472
Cdd:PRK07764 540 V LG V RGDT lv LGFSTG glar R F a S P GNAEV l VTA L AEEL G GDWQVEA V VGPAPGAAGGEG P PAPASSG P PEE aar P A A PA 619
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 473 LA A HTYT P ITSSVSTIRQYPVS A Q AP NS A ITAQTGVG VA ST vhl NPMQLMTVDASH A RHIQGIQ P A P ISTQGIQP AP I G T 552
Cdd:PRK07764 620 AP A APAA P APAGAAAAPAEASA A P AP GV A APEHHPKH VA VP --- DASDGGDGWPAK A GGAAPAA P P P APAPAAPA AP A G A 696
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866008 553 PGI QPAP LGTQGIHSATPINTQGLQ P APMGTQQPQPEGKTSA V V L ADGAT iv AN P ISNPFS A A P AATTVVQTHSQS A STN 632
Cdd:PRK07764 697 APA QPAP APAATPPAGQADDPAAQP P QAAQGASAPSPAADDP V P L PPEPD -- DP P DPAGAP A Q P PPPPAPAPAAAP A AAP 774
410
....*....|.
gi 1057866008 633 A P AQG S SPRPS 643
Cdd:PRK07764 775 P P SPP S EEEEM 785
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
