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histone deacetylase complex subunit SAP130 isoform d [Homo sapiens]
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
634-1004
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 578.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 634 A Q GSSPRPSILRKKPAT D GAKPK SE IHV SM A T PVTV SM E TVSN QN ND Q P T IAVP P TA Q Q P PPT IPT MI A A A S PPSQP A V A 713
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E GAKPK PD IHV AV A P PVTV AV E ALPG QN SE Q Q T ASAS P PS Q H P AQA IPT IL A P A A PPSQP S V V 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 714 LST I P G A VPI TPPI T --- TIAA APP PSVTVGGSLSSVLGPPV PEIK V K E E V EPMD IMR pvs A VPPL ATNTV SP S L AL LAN 790
Cdd:pfam16014 81 LST L P A A MAV TPPI P asm ANVV APP TQPAASSTAACAVSSVL PEIK I K Q E A EPMD TSQ --- S VPPL TPTSI SP A L TS LAN 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 791 NLS M P TS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS TA K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPI 870
Cdd:pfam16014 158 NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS AP K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPI 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 871 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S CRAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I I 950
Cdd:pfam16014 238 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T CRAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L I 317
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1057866354 951 PKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLDHKDRVLKLLN 1004
Cdd:pfam16014 318 PKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLDHKDRVLKLLN 371
PHA03247 super family
cl33720 large tegument protein UL36; Provisional
19-339
1.63e-05
large tegument protein UL36; Provisional
PHA03247 :Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.17
E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 19 A PS QIANSGSAGLIN P AATVND E SG RD SEVSA R EHMSSSSSLQS R EEKQEPVVV RP YPQVQMLSTHHAVAS A T P VAVTAP 98
Cdd:PHA03247 2628 P PS PSPAANEPDPHP P PTVPPP E RP RD DPAPG R VSRPRRARRLG R AAQASSPPQ RP RRRAARPTVGSLTSL A D P PPPPPT 2707
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 99 P AHLTP A VPLSFSEGLMKPPPKPTM P SR P I APAPP STLS l P P KV PG QVTVTMESSIPQASAI P VATISGQQ G H P SN L HHI 178
Cdd:PHA03247 2708 P EPAPH A LVSATPLPPGPAAARQAS P AL P A APAPP AVPA - G P AT PG GPARPARPPTTAGPPA P APPAAPAA G P P RR L TRP 2786
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 179 MTTNVQM S IIRSNA P GP P LHIG A SH L PR gaaaaavms SSKVTTVLR P TSQ LP NAAT AQP AVQHIIHQ P IQ sr P PVTTSNA 258
Cdd:PHA03247 2787 AVASLSE S RESLPS P WD P ADPP A AV L AP --------- AAALPPAAS P AGP LP PPTS AQP TAPPPPPG P PP -- P SLPLGGS 2855
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 259 IP P AVVATVSATRAQSPVITTTA A HATDSA L S RP TL S IQHPPS A -- AISIQ RP A Q SRDVTTRITL P SH P ALGT P KQQLHT 336
Cdd:PHA03247 2856 VA P GGDVRRRPPSRSPAAKPAAP A RPPVRR L A RP AV S RSTESF A lp PDQPE RP P Q PQAPPPPQPQ P QP P PPPQ P QPPPPP 2935
...
gi 1057866354 337 MAQ 339
Cdd:PHA03247 2936 PPR 2938
PHA03247 super family
cl33720 large tegument protein UL36; Provisional
347-850
4.16e-05
large tegument protein UL36; Provisional
PHA03247 :Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 48.01
E-value: 4.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 347 T P VAAATVA P ILATNTI P SATT A GSV S HTQAPTSTIVTMTV P SHSSHATA V TTSNI P VAKVV P QQITHTSPRIQ P DY P AE 426
Cdd:PHA03247 2552 P P PLPPAAP P AAPDRSV P PPRP A PRP S EPAVTSRARRPDAP P QSARPRAP V DDRGD P RGPAP P SPLPPDTHAPD P PP P SP 2631
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 427 RSSLIPISG H RASPN P VAMET R S D NR P S ------- VPVQFQYFLPTY PP SAY -- PL A AH T YTPI TS SVSTIRQY P VSAQ A 497
Cdd:PHA03247 2632 SPAANEPDP H PPPTV P PPERP R D D PA P G rvsrprr ARRLGRAAQASS PP QRP rr RA A RP T VGSL TS LADPPPPP P TPEP A 2711
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 498 P NSAIT A QTGVGVASTVHLNPMQ L MTVD A SH A RHIQGIQ P APISTQGIQ P API G T P GIQ P -- AP LGTQGIHSAT P INTQG 575
Cdd:PHA03247 2712 P HALVS A TPLPPGPAAARQASPA L PAAP A PP A VPAGPAT P GGPARPARP P TTA G P P APA P pa AP AAGPPRRLTR P AVASL 2791
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 576 LQPAPMGTQQPQ P EGKTSV VLA DG A TI va N P ISN P FSAA P AA T TVVQ T HSQ ----- SASTNAPAQGSS P RPSIL R KK P A - 649
Cdd:PHA03247 2792 SESRESLPSPWD P ADPPAA VLA PA A AL -- P P AAS P AGPL P PP T SAQP T APP pppgp PPPSLPLGGSVA P GGDVR R RP P S r 2869
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 650 TDG AKP KSEIHV --- SM A T P VT vsme TV S NQNNDQ P TIAVPPTA Q QPP P TI P TMIAAAS PP S QP AVALSTI P GAV P ITP P 726
Cdd:PHA03247 2870 SPA AKP AAPARP pvr RL A R P AV ---- SR S TESFAL P PDQPERPP Q PQA P PP P QPQPQPP PP P QP QPPPPPP P RPQ P PLA P 2945
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 727 I T TI A A A PP PS VT V GGSLSSV L G P --- P VP EIK V KEEVEPMDI mr P V S AV PPL a T NTVSPSLALL A NN L SMPTSDL PP GA 803
Cdd:PHA03247 2946 T T DP A G A GE PS GA V PQPWLGA L V P grv A VP RFR V PQPAPSREA -- P A S ST PPL - T GHSLSRVSSW A SS L ALHEETD PP PV 3022
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 1057866354 804 S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S TAKS L LVKAEKRKS P P 850
Cdd:PHA03247 3023 S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P F 3066
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
634-1004
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 578.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 634 A Q GSSPRPSILRKKPAT D GAKPK SE IHV SM A T PVTV SM E TVSN QN ND Q P T IAVP P TA Q Q P PPT IPT MI A A A S PPSQP A V A 713
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E GAKPK PD IHV AV A P PVTV AV E ALPG QN SE Q Q T ASAS P PS Q H P AQA IPT IL A P A A PPSQP S V V 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 714 LST I P G A VPI TPPI T --- TIAA APP PSVTVGGSLSSVLGPPV PEIK V K E E V EPMD IMR pvs A VPPL ATNTV SP S L AL LAN 790
Cdd:pfam16014 81 LST L P A A MAV TPPI P asm ANVV APP TQPAASSTAACAVSSVL PEIK I K Q E A EPMD TSQ --- S VPPL TPTSI SP A L TS LAN 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 791 NLS M P TS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS TA K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPI 870
Cdd:pfam16014 158 NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS AP K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPI 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 871 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S CRAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I I 950
Cdd:pfam16014 238 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T CRAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L I 317
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1057866354 951 PKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLDHKDRVLKLLN 1004
Cdd:pfam16014 318 PKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLDHKDRVLKLLN 371
PHA03247
PHA03247 large tegument protein UL36; Provisional
19-339
1.63e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.17
E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 19 A PS QIANSGSAGLIN P AATVND E SG RD SEVSA R EHMSSSSSLQS R EEKQEPVVV RP YPQVQMLSTHHAVAS A T P VAVTAP 98
Cdd:PHA03247 2628 P PS PSPAANEPDPHP P PTVPPP E RP RD DPAPG R VSRPRRARRLG R AAQASSPPQ RP RRRAARPTVGSLTSL A D P PPPPPT 2707
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 99 P AHLTP A VPLSFSEGLMKPPPKPTM P SR P I APAPP STLS l P P KV PG QVTVTMESSIPQASAI P VATISGQQ G H P SN L HHI 178
Cdd:PHA03247 2708 P EPAPH A LVSATPLPPGPAAARQAS P AL P A APAPP AVPA - G P AT PG GPARPARPPTTAGPPA P APPAAPAA G P P RR L TRP 2786
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 179 MTTNVQM S IIRSNA P GP P LHIG A SH L PR gaaaaavms SSKVTTVLR P TSQ LP NAAT AQP AVQHIIHQ P IQ sr P PVTTSNA 258
Cdd:PHA03247 2787 AVASLSE S RESLPS P WD P ADPP A AV L AP --------- AAALPPAAS P AGP LP PPTS AQP TAPPPPPG P PP -- P SLPLGGS 2855
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 259 IP P AVVATVSATRAQSPVITTTA A HATDSA L S RP TL S IQHPPS A -- AISIQ RP A Q SRDVTTRITL P SH P ALGT P KQQLHT 336
Cdd:PHA03247 2856 VA P GGDVRRRPPSRSPAAKPAAP A RPPVRR L A RP AV S RSTESF A lp PDQPE RP P Q PQAPPPPQPQ P QP P PPPQ P QPPPPP 2935
...
gi 1057866354 337 MAQ 339
Cdd:PHA03247 2936 PPR 2938
PHA03247
PHA03247 large tegument protein UL36; Provisional
347-850
4.16e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 48.01
E-value: 4.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 347 T P VAAATVA P ILATNTI P SATT A GSV S HTQAPTSTIVTMTV P SHSSHATA V TTSNI P VAKVV P QQITHTSPRIQ P DY P AE 426
Cdd:PHA03247 2552 P P PLPPAAP P AAPDRSV P PPRP A PRP S EPAVTSRARRPDAP P QSARPRAP V DDRGD P RGPAP P SPLPPDTHAPD P PP P SP 2631
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 427 RSSLIPISG H RASPN P VAMET R S D NR P S ------- VPVQFQYFLPTY PP SAY -- PL A AH T YTPI TS SVSTIRQY P VSAQ A 497
Cdd:PHA03247 2632 SPAANEPDP H PPPTV P PPERP R D D PA P G rvsrprr ARRLGRAAQASS PP QRP rr RA A RP T VGSL TS LADPPPPP P TPEP A 2711
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 498 P NSAIT A QTGVGVASTVHLNPMQ L MTVD A SH A RHIQGIQ P APISTQGIQ P API G T P GIQ P -- AP LGTQGIHSAT P INTQG 575
Cdd:PHA03247 2712 P HALVS A TPLPPGPAAARQASPA L PAAP A PP A VPAGPAT P GGPARPARP P TTA G P P APA P pa AP AAGPPRRLTR P AVASL 2791
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 576 LQPAPMGTQQPQ P EGKTSV VLA DG A TI va N P ISN P FSAA P AA T TVVQ T HSQ ----- SASTNAPAQGSS P RPSIL R KK P A - 649
Cdd:PHA03247 2792 SESRESLPSPWD P ADPPAA VLA PA A AL -- P P AAS P AGPL P PP T SAQP T APP pppgp PPPSLPLGGSVA P GGDVR R RP P S r 2869
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 650 TDG AKP KSEIHV --- SM A T P VT vsme TV S NQNNDQ P TIAVPPTA Q QPP P TI P TMIAAAS PP S QP AVALSTI P GAV P ITP P 726
Cdd:PHA03247 2870 SPA AKP AAPARP pvr RL A R P AV ---- SR S TESFAL P PDQPERPP Q PQA P PP P QPQPQPP PP P QP QPPPPPP P RPQ P PLA P 2945
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 727 I T TI A A A PP PS VT V GGSLSSV L G P --- P VP EIK V KEEVEPMDI mr P V S AV PPL a T NTVSPSLALL A NN L SMPTSDL PP GA 803
Cdd:PHA03247 2946 T T DP A G A GE PS GA V PQPWLGA L V P grv A VP RFR V PQPAPSREA -- P A S ST PPL - T GHSLSRVSSW A SS L ALHEETD PP PV 3022
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 1057866354 804 S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S TAKS L LVKAEKRKS P P 850
Cdd:PHA03247 3023 S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P F 3066
Atrophin-1
pfam03154 Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
453-785
6.20e-04
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain]
Cd Length: 991
Bit Score: 43.99
E-value: 6.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 453 P SVPV Q FQYFL P TY PP SAYPLA A H T YT P IT S SV S TIR Q - Y P VSA Q A PN SAI - TA QTGVGVAS T VH L N P MQ L MTVDASHAR 530
Cdd:pfam03154 172 P VLQA Q SGAAS P PS PP PPGTTQ A A T AG P TP S AP S VPP Q g S P ATS Q P PN QTQ s TA APHTLIQQ T PT L H P QR L PSPHPPLQP 251
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 531 HI Q GIQ P API S T Q GIQPAPIGTPGI - Q P AP L G T QGI H SAT P INT Q GLQPA P MGT Q QPQ P E G KTSVVLADGATIVAN P I S N 609
Cdd:pfam03154 252 MT Q PPP P SQV S P Q PLPQPSLHGQMP p M P HS L Q T GPS H MQH P VPP Q PFPLT P QSS Q SQV P P G PSPAAPGQSQQRIHT P P S Q 331
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 610 PFSAA -------------------- P AA TT VVQTHSQSA S TNA P AQG S S P R P ---- S I L RKK PA TDGAKPK S EI H VSM A T 665
Cdd:pfam03154 332 SQLQS qqppreqplppaplsmphik P PP TT PIPQLPNPQ S HKH P PHL S G P S P fqmn S N L PPP PA LKPLSSL S TH H PPS A H 411
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 666 P VTVSMETV S N Q ---- NNDQ P TIAVPPTAQQ P PPTI P TMIAAASP PSQ PAVAL - STI PG AV P - ITPP ITTIAAAPP ---- 735
Cdd:pfam03154 412 P PPLQLMPQ S Q Q lppp PAQP P VLTQSQSLPP P AASH P PTSGLHQV PSQ SPFPQ h PFV PG GP P p ITPP SGPPTSTSS ampg 491
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1057866354 736 ------ P SV TVG G SLSSVLGP P V P EIKV KEE v EPMDIMR P V S AV PP LATNTVS P SL 785
Cdd:pfam03154 492 iqppss A SV SSS G PVPAAVSC P L P PVQI KEE - ALDEAEE P E S PP PP PRSPSPE P TV 546
PRK07003
PRK07003 DNA polymerase III subunit gamma/tau;
579-813
7.17e-03
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain]
Cd Length: 830
Bit Score: 40.22
E-value: 7.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 579 AP M G TQQPQPE G --- KTSVVL A DGATIV A N P ISNPFSA A PA A TTVVQTHSQS A S T N A P A QGSS P R P SILRKKPATDGAKP 655
Cdd:PRK07003 367 AP G G GVPARVA G avp APGARA A AAVGAS A V P AVTAVTG A AG A ALAPKAAAAA A A T R A E A PPAA P A P PATADRGDDAADGD 446
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 656 KS eih V SMATPVTV S METVSNQNND QP TIA vpptaqqpppti PTMIA A ASPPSQ P AV A LSTI P G A VPITPPITTIAAAP - 734
Cdd:PRK07003 447 AP --- V PAKANARA S ADSRCDERDA QP PAD ------------ SGSAS A PASDAP P DA A FEPA P R A AAPSAATPAAVPDA r 511
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1057866354 735 P P SVTVGGSLSSVLG PP V PE IKVKE evepmdimr P VS A V P PLATNTVSPS L AL L A N NLSMPT SD LPPG A SPRK KP RKQQ 813
Cdd:PRK07003 512 A P AAASREDAPAAAA PP A PE ARPPT --------- P AA A A P AARAGGAAAA L DV L R N AGMRVS SD RGAR A AAAA KP AAAP 581
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
634-1004
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 578.04
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 634 A Q GSSPRPSILRKKPAT D GAKPK SE IHV SM A T PVTV SM E TVSN QN ND Q P T IAVP P TA Q Q P PPT IPT MI A A A S PPSQP A V A 713
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E GAKPK PD IHV AV A P PVTV AV E ALPG QN SE Q Q T ASAS P PS Q H P AQA IPT IL A P A A PPSQP S V V 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 714 LST I P G A VPI TPPI T --- TIAA APP PSVTVGGSLSSVLGPPV PEIK V K E E V EPMD IMR pvs A VPPL ATNTV SP S L AL LAN 790
Cdd:pfam16014 81 LST L P A A MAV TPPI P asm ANVV APP TQPAASSTAACAVSSVL PEIK I K Q E A EPMD TSQ --- S VPPL TPTSI SP A L TS LAN 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 791 NLS M P TS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS TA K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPI 870
Cdd:pfam16014 158 NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS AP K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPI 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 871 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S CRAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I I 950
Cdd:pfam16014 238 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T CRAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L I 317
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1057866354 951 PKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLDHKDRVLKLLN 1004
Cdd:pfam16014 318 PKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLDHKDRVLKLLN 371
PHA03247
PHA03247 large tegument protein UL36; Provisional
19-339
1.63e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.17
E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 19 A PS QIANSGSAGLIN P AATVND E SG RD SEVSA R EHMSSSSSLQS R EEKQEPVVV RP YPQVQMLSTHHAVAS A T P VAVTAP 98
Cdd:PHA03247 2628 P PS PSPAANEPDPHP P PTVPPP E RP RD DPAPG R VSRPRRARRLG R AAQASSPPQ RP RRRAARPTVGSLTSL A D P PPPPPT 2707
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 99 P AHLTP A VPLSFSEGLMKPPPKPTM P SR P I APAPP STLS l P P KV PG QVTVTMESSIPQASAI P VATISGQQ G H P SN L HHI 178
Cdd:PHA03247 2708 P EPAPH A LVSATPLPPGPAAARQAS P AL P A APAPP AVPA - G P AT PG GPARPARPPTTAGPPA P APPAAPAA G P P RR L TRP 2786
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 179 MTTNVQM S IIRSNA P GP P LHIG A SH L PR gaaaaavms SSKVTTVLR P TSQ LP NAAT AQP AVQHIIHQ P IQ sr P PVTTSNA 258
Cdd:PHA03247 2787 AVASLSE S RESLPS P WD P ADPP A AV L AP --------- AAALPPAAS P AGP LP PPTS AQP TAPPPPPG P PP -- P SLPLGGS 2855
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 259 IP P AVVATVSATRAQSPVITTTA A HATDSA L S RP TL S IQHPPS A -- AISIQ RP A Q SRDVTTRITL P SH P ALGT P KQQLHT 336
Cdd:PHA03247 2856 VA P GGDVRRRPPSRSPAAKPAAP A RPPVRR L A RP AV S RSTESF A lp PDQPE RP P Q PQAPPPPQPQ P QP P PPPQ P QPPPPP 2935
...
gi 1057866354 337 MAQ 339
Cdd:PHA03247 2936 PPR 2938
PHA03247
PHA03247 large tegument protein UL36; Provisional
347-850
4.16e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 48.01
E-value: 4.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 347 T P VAAATVA P ILATNTI P SATT A GSV S HTQAPTSTIVTMTV P SHSSHATA V TTSNI P VAKVV P QQITHTSPRIQ P DY P AE 426
Cdd:PHA03247 2552 P P PLPPAAP P AAPDRSV P PPRP A PRP S EPAVTSRARRPDAP P QSARPRAP V DDRGD P RGPAP P SPLPPDTHAPD P PP P SP 2631
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 427 RSSLIPISG H RASPN P VAMET R S D NR P S ------- VPVQFQYFLPTY PP SAY -- PL A AH T YTPI TS SVSTIRQY P VSAQ A 497
Cdd:PHA03247 2632 SPAANEPDP H PPPTV P PPERP R D D PA P G rvsrprr ARRLGRAAQASS PP QRP rr RA A RP T VGSL TS LADPPPPP P TPEP A 2711
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 498 P NSAIT A QTGVGVASTVHLNPMQ L MTVD A SH A RHIQGIQ P APISTQGIQ P API G T P GIQ P -- AP LGTQGIHSAT P INTQG 575
Cdd:PHA03247 2712 P HALVS A TPLPPGPAAARQASPA L PAAP A PP A VPAGPAT P GGPARPARP P TTA G P P APA P pa AP AAGPPRRLTR P AVASL 2791
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 576 LQPAPMGTQQPQ P EGKTSV VLA DG A TI va N P ISN P FSAA P AA T TVVQ T HSQ ----- SASTNAPAQGSS P RPSIL R KK P A - 649
Cdd:PHA03247 2792 SESRESLPSPWD P ADPPAA VLA PA A AL -- P P AAS P AGPL P PP T SAQP T APP pppgp PPPSLPLGGSVA P GGDVR R RP P S r 2869
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 650 TDG AKP KSEIHV --- SM A T P VT vsme TV S NQNNDQ P TIAVPPTA Q QPP P TI P TMIAAAS PP S QP AVALSTI P GAV P ITP P 726
Cdd:PHA03247 2870 SPA AKP AAPARP pvr RL A R P AV ---- SR S TESFAL P PDQPERPP Q PQA P PP P QPQPQPP PP P QP QPPPPPP P RPQ P PLA P 2945
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 727 I T TI A A A PP PS VT V GGSLSSV L G P --- P VP EIK V KEEVEPMDI mr P V S AV PPL a T NTVSPSLALL A NN L SMPTSDL PP GA 803
Cdd:PHA03247 2946 T T DP A G A GE PS GA V PQPWLGA L V P grv A VP RFR V PQPAPSREA -- P A S ST PPL - T GHSLSRVSSW A SS L ALHEETD PP PV 3022
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 1057866354 804 S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S TAKS L LVKAEKRKS P P 850
Cdd:PHA03247 3023 S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P F 3066
PHA03247
PHA03247 large tegument protein UL36; Provisional
98-492
7.70e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 46.86
E-value: 7.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 98 PP AH L T PA --------- VP LSFSEGLMKP P PKPTMPS RP I AP APPSTLSL P PKVP G QVTVTMES S - I P QASAI P VATISG 167
Cdd:PHA03247 2551 PP PP L P PA appaapdrs VP PPRPAPRPSE P AVTSRAR RP D AP PQSARPRA P VDDR G DPRGPAPP S p L P PDTHA P DPPPPS 2630
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 168 QQGHPSNLHHIMTTN V QMSIIRSNA P G P P ------------ LHIG AS HL P RGAAAA A VMSS - SKV T TVLR P TSQL P NAAT 234
Cdd:PHA03247 2631 PSPAANEPDPHPPPT V PPPERPRDD P A P G rvsrprrarrlg RAAQ AS SP P QRPRRR A ARPT v GSL T SLAD P PPPP P TPEP 2710
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 235 A QP A VQHIIHQ P IQSRPPVTT S N A I P P A VVATVSATRAQS P V - ITTT A AHA T DSALSR P TLSIQHPPSAAISIQ RPA QSR 313
Cdd:PHA03247 2711 A PH A LVSATPL P PGPAAARQA S P A L P A A PAPPAVPAGPAT P G g PARP A RPP T TAGPPA P APPAAPAAGPPRRLT RPA VAS 2790
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 314 DVTT R IT LPS ------ H PA LGTPKQQLHTM A QKTIFSTGT P VA A ATV AP ILATNTI P SATTA G SVSHTQAP tsti V TMTV 387
Cdd:PHA03247 2791 LSES R ES LPS pwdpad P PA AVLAPAAALPP A ASPAGPLPP P TS A QPT AP PPPPGPP P PSLPL G GSVAPGGD ---- V RRRP 2866
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 388 PS H S SH A TAVTTSNI PV AKV vpqqithts P R IQPDYPA E RSS L I P ISGH R ASPNPVAMETRSDNR P SV P V Q F Q YFL P TY P 467
Cdd:PHA03247 2867 PS R S PA A KPAAPARP PV RRL --------- A R PAVSRST E SFA L P P DQPE R PPQPQAPPPPQPQPQ P PP P P Q P Q PPP P PP P 2937
410 420
....*....|....*....|....*
gi 1057866354 468 PSAY PLA AH T YTPITSSV S TIRQY P 492
Cdd:PHA03247 2938 RPQP PLA PT T DPAGAGEP S GAVPQ P 2962
Atrophin-1
pfam03154 Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
453-785
6.20e-04
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain]
Cd Length: 991
Bit Score: 43.99
E-value: 6.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 453 P SVPV Q FQYFL P TY PP SAYPLA A H T YT P IT S SV S TIR Q - Y P VSA Q A PN SAI - TA QTGVGVAS T VH L N P MQ L MTVDASHAR 530
Cdd:pfam03154 172 P VLQA Q SGAAS P PS PP PPGTTQ A A T AG P TP S AP S VPP Q g S P ATS Q P PN QTQ s TA APHTLIQQ T PT L H P QR L PSPHPPLQP 251
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 531 HI Q GIQ P API S T Q GIQPAPIGTPGI - Q P AP L G T QGI H SAT P INT Q GLQPA P MGT Q QPQ P E G KTSVVLADGATIVAN P I S N 609
Cdd:pfam03154 252 MT Q PPP P SQV S P Q PLPQPSLHGQMP p M P HS L Q T GPS H MQH P VPP Q PFPLT P QSS Q SQV P P G PSPAAPGQSQQRIHT P P S Q 331
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 610 PFSAA -------------------- P AA TT VVQTHSQSA S TNA P AQG S S P R P ---- S I L RKK PA TDGAKPK S EI H VSM A T 665
Cdd:pfam03154 332 SQLQS qqppreqplppaplsmphik P PP TT PIPQLPNPQ S HKH P PHL S G P S P fqmn S N L PPP PA LKPLSSL S TH H PPS A H 411
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 666 P VTVSMETV S N Q ---- NNDQ P TIAVPPTAQQ P PPTI P TMIAAASP PSQ PAVAL - STI PG AV P - ITPP ITTIAAAPP ---- 735
Cdd:pfam03154 412 P PPLQLMPQ S Q Q lppp PAQP P VLTQSQSLPP P AASH P PTSGLHQV PSQ SPFPQ h PFV PG GP P p ITPP SGPPTSTSS ampg 491
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1057866354 736 ------ P SV TVG G SLSSVLGP P V P EIKV KEE v EPMDIMR P V S AV PP LATNTVS P SL 785
Cdd:pfam03154 492 iqppss A SV SSS G PVPAAVSC P L P PVQI KEE - ALDEAEE P E S PP PP PRSPSPE P TV 546
PRK07003
PRK07003 DNA polymerase III subunit gamma/tau;
579-813
7.17e-03
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain]
Cd Length: 830
Bit Score: 40.22
E-value: 7.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 579 AP M G TQQPQPE G --- KTSVVL A DGATIV A N P ISNPFSA A PA A TTVVQTHSQS A S T N A P A QGSS P R P SILRKKPATDGAKP 655
Cdd:PRK07003 367 AP G G GVPARVA G avp APGARA A AAVGAS A V P AVTAVTG A AG A ALAPKAAAAA A A T R A E A PPAA P A P PATADRGDDAADGD 446
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057866354 656 KS eih V SMATPVTV S METVSNQNND QP TIA vpptaqqpppti PTMIA A ASPPSQ P AV A LSTI P G A VPITPPITTIAAAP - 734
Cdd:PRK07003 447 AP --- V PAKANARA S ADSRCDERDA QP PAD ------------ SGSAS A PASDAP P DA A FEPA P R A AAPSAATPAAVPDA r 511
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1057866354 735 P P SVTVGGSLSSVLG PP V PE IKVKE evepmdimr P VS A V P PLATNTVSPS L AL L A N NLSMPT SD LPPG A SPRK KP RKQQ 813
Cdd:PRK07003 512 A P AAASREDAPAAAA PP A PE ARPPT --------- P AA A A P AARAGGAAAA L DV L R N AGMRVS SD RGAR A AAAA KP AAAP 581
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
