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Conserved domains on  [gi|1047600449|ref|NP_001316704|]
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zinc finger protein 875 isoform j [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
238-597 1.68e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 238 KPYVCRECGRGFTWKSNLITHQRTHSGEKPYVCKDCGRG--FTWKSNLFTHQRTHSGLKPYVCkeCGQSFSLKSNLITHQ 315
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 316 RAHTGEKP-YVCRECGRGFRQHSHLV----RHKRTHSGEKPY---------------------ICRECEQGFSQKSHLIR 369
Cdd:COG5048   110 LSSSSSNSnDNNLLSSHSLPPSSRDPqlpdLLSISNLRNNPLpgnnsssvntpqsnslhpplpANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 370 HLRTHTGEKPYVCTEcgRHFSWK-SNLKTHQRTHSGVKPYVCLECGQCFSLKSNLNKHQRSHTGEKPFVCTECGRGF--T 446
Cdd:COG5048   190 SNVSTSIPSSSENSP--LSSSYSiPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 447 RKSTLSTHQRTHSGE-----KPFVCAECGRGFNDKSTLISHQRT--HSGE--KPFMCRE--CGRRFRQKPNLFRHKRAHS 515
Cdd:COG5048   268 ASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 516 GAFVCRECGQGFCAKLTLIKHQRAHA---------GGKPHVC--RECGQGFSRQSHLIRHQRTHSGEKP--YICRKCGRG 582
Cdd:COG5048   348 SISPAKEKLLNSSSKFSPLLNNEPPQslqqykdlkNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                         410
                  ....*....|....*
gi 1047600449 583 FSRKSNLIRHQRTHS 597
Cdd:COG5048   428 FNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
238-597 1.68e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 238 KPYVCRECGRGFTWKSNLITHQRTHSGEKPYVCKDCGRG--FTWKSNLFTHQRTHSGLKPYVCkeCGQSFSLKSNLITHQ 315
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 316 RAHTGEKP-YVCRECGRGFRQHSHLV----RHKRTHSGEKPY---------------------ICRECEQGFSQKSHLIR 369
Cdd:COG5048   110 LSSSSSNSnDNNLLSSHSLPPSSRDPqlpdLLSISNLRNNPLpgnnsssvntpqsnslhpplpANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 370 HLRTHTGEKPYVCTEcgRHFSWK-SNLKTHQRTHSGVKPYVCLECGQCFSLKSNLNKHQRSHTGEKPFVCTECGRGF--T 446
Cdd:COG5048   190 SNVSTSIPSSSENSP--LSSSYSiPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 447 RKSTLSTHQRTHSGE-----KPFVCAECGRGFNDKSTLISHQRT--HSGE--KPFMCRE--CGRRFRQKPNLFRHKRAHS 515
Cdd:COG5048   268 ASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 516 GAFVCRECGQGFCAKLTLIKHQRAHA---------GGKPHVC--RECGQGFSRQSHLIRHQRTHSGEKP--YICRKCGRG 582
Cdd:COG5048   348 SISPAKEKLLNSSSKFSPLLNNEPPQslqqykdlkNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                         410
                  ....*....|....*
gi 1047600449 583 FSRKSNLIRHQRTHS 597
Cdd:COG5048   428 FNRHYNLIPHKKIHT 442
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 462-510 9.13e-06

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 44.08  E-value: 9.13e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1047600449 462 KPFvCAECGRGFNDKSTLISHQRthsgEKPFMCRECGRRFRQKPNLFRH 510
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
366-390 6.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.52e-04
                          10        20
                  ....*....|....*....|....*
gi 1047600449 366 HLIRHLRTHTGEKPYVCTECGRHFS 390
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
238-597 1.68e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 238 KPYVCRECGRGFTWKSNLITHQRTHSGEKPYVCKDCGRG--FTWKSNLFTHQRTHSGLKPYVCkeCGQSFSLKSNLITHQ 315
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 316 RAHTGEKP-YVCRECGRGFRQHSHLV----RHKRTHSGEKPY---------------------ICRECEQGFSQKSHLIR 369
Cdd:COG5048   110 LSSSSSNSnDNNLLSSHSLPPSSRDPqlpdLLSISNLRNNPLpgnnsssvntpqsnslhpplpANSLSKDPSSNLSLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 370 HLRTHTGEKPYVCTEcgRHFSWK-SNLKTHQRTHSGVKPYVCLECGQCFSLKSNLNKHQRSHTGEKPFVCTECGRGF--T 446
Cdd:COG5048   190 SNVSTSIPSSSENSP--LSSSYSiPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpT 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 447 RKSTLSTHQRTHSGE-----KPFVCAECGRGFNDKSTLISHQRT--HSGE--KPFMCRE--CGRRFRQKPNLFRHKRAHS 515
Cdd:COG5048   268 ASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 516 GAFVCRECGQGFCAKLTLIKHQRAHA---------GGKPHVC--RECGQGFSRQSHLIRHQRTHSGEKP--YICRKCGRG 582
Cdd:COG5048   348 SISPAKEKLLNSSSKFSPLLNNEPPQslqqykdlkNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                         410
                  ....*....|....*
gi 1047600449 583 FSRKSNLIRHQRTHS 597
Cdd:COG5048   428 FNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
322-598 2.26e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 2.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 322 KPYVCRECGRGFRQHSHLVRHKRTHSGEKPYICR--ECEQGFSQKSHLIRHLRTHTGEKPYVCTECGR------------ 387
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 388 HFSWKSNLKTHQRTHSGVKP--------------YVCLECGQCFSLKSNLNKHQRSHtgeKPFVCTECGRGFTRKSTLST 453
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSsrdpqlpdllsisnLRNNPLPGNNSSSVNTPQSNSLH---PPLPANSLSKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 454 HQRTHSGEKPFVCAECGRGFNDKSTLISHQRTHSGEKPFMCRECGRRFRQKPNLFRHKRAHSGAFVCRECGQGFCAKLTL 533
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 534 IKHQRAH---------AGGKPHVCRECGQGFSRQSHLIRHQRT--HSGE--KPYICRK--CGRGFSRKSNLIRHQRTHSG 598
Cdd:COG5048   269 SSQSSSPnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
251-438 5.46e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 5.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 251 WKSNLITHQRTHSGEKPYVCKDCGRGFTWKSNLFTHQRTHSG-LKPYVCKECGQSFSLKSNLITHQRA--HTGE--KPYV 325
Cdd:COG5048   244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFS 323

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 326 CRE--CGRGFRQHSHLVRHKRTHSGEKPYICRECE------QGFSQKSHLIRHLR-THTGEKPYVCT--ECGRHFSWKSN 394
Cdd:COG5048   324 CPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfsPLLNNEPPQSLQQYkDLKNDKKSETLsnSCIRNFKRDSN 403

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1047600449 395 LKTHQRTHSGVKPYVC--LECGQCFSLKSNLNKHQRSHTGEKPFVC 438
Cdd:COG5048   404 LSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 462-510 9.13e-06

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 44.08  E-value: 9.13e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1047600449 462 KPFvCAECGRGFNDKSTLISHQRthsgEKPFMCRECGRRFRQKPNLFRH 510
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
366-390 6.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.52e-04
                          10        20
                  ....*....|....*....|....*
gi 1047600449 366 HLIRHLRTHTGEKPYVCTECGRHFS 390
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 574-596 1.02e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|...
gi 1047600449 574 YICRKCGRGFSRKSNLIRHQRTH 596
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 546-568 3.01e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.01e-03
                          10        20
                  ....*....|....*....|...
gi 1047600449 546 HVCRECGQGFSRQSHLIRHQRTH 568
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 436-458 5.06e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.06e-03
                          10        20
                  ....*....|....*....|...
gi 1047600449 436 FVCTECGRGFTRKSTLSTHQRTH 458
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
254-278 6.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.19e-03
                          10        20
                  ....*....|....*....|....*
gi 1047600449 254 NLITHQRTHSGEKPYVCKDCGRGFT 278
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
394-418 7.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.31e-03
                          10        20
                  ....*....|....*....|....*
gi 1047600449 394 NLKTHQRTHSGVKPYVCLECGQCFS 418
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
282-306 9.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.26e-03
                          10        20
                  ....*....|....*....|....*
gi 1047600449 282 NLFTHQRTHSGLKPYVCKECGQSFS 306
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
198-372 9.36e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 38.91  E-value: 9.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 198 NLLSLQKTQTGETPYMYTEWGDSFGSMSVLIKNPRT--HSG--GKPYVCRE--CGRGFTWKSNLITHQRTHSGEKPYVCK 271
Cdd:COG5048   276 NESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1047600449 272 DCGRGFTWKSNL-------FTHQRTHSGLKPYVC--KECGQSFSLKSNLITHQRAHTGEKPYVCR--ECGRGFRQHSHLV 340
Cdd:COG5048   356 LLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLI 435

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1047600449 341 RHKRTHSgEKPYICRECEQGFSQKSHLIRHLR 372
Cdd:COG5048   436 PHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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