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Conserved domains on  [gi|1045961265|ref|NP_001316597|]
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COMM domain-containing protein 8 isoform 2 [Homo sapiens]

Protein Classification

COMM domain-containing protein 8( domain architecture ID 10140836)

COMM domain-containing protein 8 (COMMD8) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and may also down-regulate activation of NF-kappa-B

Gene Symbol:  COMMD8
Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 7-180 6.44e-97

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 278.14  E-value: 6.44e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045961265   7 TPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAKFFKAIVGKNLPDEEIFQQLNQLNSLH 86
Cdd:cd04756     1 TPPELINLLPVAQIVKLLHRVVDGVCGRAYPRYQDYSAIWSLEEWTEVLESLATLFKQAVGKNSNDEEAKAQLSDLSSSH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045961265  87 QETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQ--LALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQ 164
Cdd:cd04756    81 QEALLKCVKSRKEEIRQALVNKTNSISSAQLQDFDWQlkLALSSDKLSSLQEPLLNLDLDVKENGILKPVSIEMNKEELQ 160

                         170
                  ....*....|....*.
gi 1045961265 165 NLIQSLEAANKVVLQL 180
Cdd:cd04756   161 NLISSLEAANKVVLQL 176
 
Name Accession Description Interval E-value
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 7-180 6.44e-97

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 278.14  E-value: 6.44e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045961265   7 TPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAKFFKAIVGKNLPDEEIFQQLNQLNSLH 86
Cdd:cd04756     1 TPPELINLLPVAQIVKLLHRVVDGVCGRAYPRYQDYSAIWSLEEWTEVLESLATLFKQAVGKNSNDEEAKAQLSDLSSSH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045961265  87 QETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQ--LALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQ 164
Cdd:cd04756    81 QEALLKCVKSRKEEIRQALVNKTNSISSAQLQDFDWQlkLALSSDKLSSLQEPLLNLDLDVKENGILKPVSIEMNKEELQ 160

                         170
                  ....*....|....*.
gi 1045961265 165 NLIQSLEAANKVVLQL 180
Cdd:cd04756   161 NLISSLEAANKVVLQL 176
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 113-173 1.25e-11

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 57.17  E-value: 1.25e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1045961265 113 SSAQLQDFDWQL--ALSSDKIAALRMPLLSLHLDVKEN-GEVKPYSIEMSREELQNLIQSLEAA 173
Cdd:pfam07258   1 SLPQLVDLDWRLdvQLSSSSLSKVNEPVVLLELKLSDGdGSSEEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 7-180 6.44e-97

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 278.14  E-value: 6.44e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045961265   7 TPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAKFFKAIVGKNLPDEEIFQQLNQLNSLH 86
Cdd:cd04756     1 TPPELINLLPVAQIVKLLHRVVDGVCGRAYPRYQDYSAIWSLEEWTEVLESLATLFKQAVGKNSNDEEAKAQLSDLSSSH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045961265  87 QETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQ--LALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQ 164
Cdd:cd04756    81 QEALLKCVKSRKEEIRQALVNKTNSISSAQLQDFDWQlkLALSSDKLSSLQEPLLNLDLDVKENGILKPVSIEMNKEELQ 160

                         170
                  ....*....|....*.
gi 1045961265 165 NLIQSLEAANKVVLQL 180
Cdd:cd04756   161 NLISSLEAANKVVLQL 176
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 93-177 2.51e-12

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 59.63  E-value: 2.51e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045961265  93 CVKSRKDEIKQALSREivAISSAQLQDFDWQL--ALSSDKIAALRMP--LLSLHLDVKENGEVKPYSIEMSREELQNLIQ 168
Cdd:cd04748     1 LLTENKAEIEELLSKQ--SLSLPQLVDFDWRLdvQISSSSLAKVKQPtiLVQLKLQVGDNNSSEKICFEMTKEELQNFLN 78


                  ....*....
gi 1045961265 169 SLEAANKVV 177
Cdd:cd04748    79 KLKKIKAQL 87
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 113-173 1.25e-11

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 57.17  E-value: 1.25e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1045961265 113 SSAQLQDFDWQL--ALSSDKIAALRMPLLSLHLDVKEN-GEVKPYSIEMSREELQNLIQSLEAA 173
Cdd:pfam07258   1 SLPQLVDLDWRLdvQLSSSSLSKVNEPVVLLELKLSDGdGSSEEVTFELSKEQLQDLLNELEEA 64
PEPCK_GTP cd00819
Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the ...
 49-82 4.45e-03

Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and phosphorylation of oxaloacetate to yield phosphoenolpyruvate and carbon dioxide, using a nucleotide molecule (GTP) for the phosphoryl transfer, and has a strict requirement for divalent metal ions for activity. PEPCK's separate into two phylogenetic groups based on their nucleotide substrate specificity, this model describes the GTP-dependent group.


Pssm-ID: 238417  Cd Length: 579  Bit Score: 36.84  E-value: 4.45e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1045961265  49 EEWMHVLEDIAKFFKAIVGKNLPdEEIFQQLNQL 82
Cdd:cd00819   547 DYWLQELIEIEEYLEKIGRADLP-QELFDELEAL 579
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 77-173 7.87e-03

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 35.48  E-value: 7.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045961265  77 QQLNqLNSLHQETIMKCVKSRKDEIKQALSREIVAISsaQLQDFDWQL--ALSSDKIAALRMPLLSLHLDVK--ENGEVK 152
Cdd:cd04752    70 QQLG-LPKEHATSLCRSYEEKQSKLQESLRANSLRLS--RLESVDWRVdyILSSSELQEVNEPLVQLRLKVRnaDTGEIT 146

                          90       100
                  ....*....|....*....|.
gi 1045961265 153 PYSIEMSREELQNLIQSLEAA 173
Cdd:cd04752   147 PHPFSVSADKFRVLLAELKQA 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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