NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1037195632|ref|NP_001315461|]
View 

mesoderm-specific transcript homolog protein isoform 2 [Danio rerio]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 53-342 5.62e-23

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 95.07  E-value: 5.62e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632  53 TSGHFFTFRGNDIFYKESvGVVGssDVLVLLHGFPTSSYDWYKIWDSLTQRFnRVIALDFLGFGFSDKPRPHrYSIFEQA 132
Cdd:COG0596     2 STPRFVTVDGVRLHYREA-GPDG--PPVVLLHGLPGSSYEWRPLIPALAAGY-RVIAPDLRGHGRSDKPAGG-YTLDDLA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632 133 SVVEALVAHLGLseQRINILSHDYGDTVALELLYRSDHNrsghiiVNSLCLSNGGIfpethhpRFLQKVLKDSGFISPVL 212
Cdd:COG0596    77 DDLAALLDALGL--ERVVLVGHSMGGMVALELAARHPER------VAGLVLVDEVL-------AALAEPLRRPGLAPEAL 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632 213 TRLMnfqlfsrgikevfgpyTQPTEAEVWDMWTGIRfndgnlvmdsllqyinqrlkhrerwvgaltstlTPLHMIYGPLD 292
Cdd:COG0596   142 AALL----------------RALARTDLRERLARIT---------------------------------VPTLVIWGEKD 172

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1037195632 293 PVNPhPQFLQLYQKLVQRSTVSVLdEHVSHYPQLEDPTGFFNAYLSFINS 342
Cdd:COG0596   173 PIVP-PALARRLAELLPNAELVVL-PGAGHFPPLEQPEAFAAALRDFLAR 220
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 53-342 5.62e-23

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 95.07  E-value: 5.62e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632  53 TSGHFFTFRGNDIFYKESvGVVGssDVLVLLHGFPTSSYDWYKIWDSLTQRFnRVIALDFLGFGFSDKPRPHrYSIFEQA 132
Cdd:COG0596     2 STPRFVTVDGVRLHYREA-GPDG--PPVVLLHGLPGSSYEWRPLIPALAAGY-RVIAPDLRGHGRSDKPAGG-YTLDDLA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632 133 SVVEALVAHLGLseQRINILSHDYGDTVALELLYRSDHNrsghiiVNSLCLSNGGIfpethhpRFLQKVLKDSGFISPVL 212
Cdd:COG0596    77 DDLAALLDALGL--ERVVLVGHSMGGMVALELAARHPER------VAGLVLVDEVL-------AALAEPLRRPGLAPEAL 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632 213 TRLMnfqlfsrgikevfgpyTQPTEAEVWDMWTGIRfndgnlvmdsllqyinqrlkhrerwvgaltstlTPLHMIYGPLD 292
Cdd:COG0596   142 AALL----------------RALARTDLRERLARIT---------------------------------VPTLVIWGEKD 172

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1037195632 293 PVNPhPQFLQLYQKLVQRSTVSVLdEHVSHYPQLEDPTGFFNAYLSFINS 342
Cdd:COG0596   173 PIVP-PALARRLAELLPNAELVVL-PGAGHFPPLEQPEAFAAALRDFLAR 220
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 78-329 4.82e-18

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 82.17  E-value: 4.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632  78 DVLVLLHGFPTSSYDWYKIWDSLTQRFNRVIALDFLGFGFSDKPR-PHRYSIFEQASVVEALVAHLGLseQRINILSHDY 156
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRPKaQDDYRTDDLAEDLEYILEALGL--EKVNLVGHSM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632 157 GDTVALELLYRSDHNRSGHIIVNSLCLSNGGIFPETH----HPRFLQKVLkdSGFISPVLTRLMNFQLfsrgikevfGPY 232
Cdd:pfam00561  79 GGLIALAYAAKYPDRVKALVLLGALDPPHELDEADRFilalFPGFFDGFV--ADFAPNPLGRLVAKLL---------ALL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632 233 TQPTEAE------VWDMWTGIRFNDGNLVMDSLLQYINQRLKHRERWVGALTStltPLHMIYGPLDPVNPhPQFLQLYQK 306
Cdd:pfam00561 148 LLRLRLLkalpllNKRFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRLDE---PTLIIWGDQDPLVP-PQALEKLAQ 223

                         250       260
                  ....*....|....*....|...
gi 1037195632 307 LVQRSTVsVLDEHVSHYPQLEDP 329
Cdd:pfam00561 224 LFPNARL-VVIPDAGHFAFLEGP 245
PRK03204 PRK03204
haloalkane dehalogenase; Provisional
 39-162 5.06e-12

haloalkane dehalogenase; Provisional


Pssm-ID: 179554 [Multi-domain]  Cd Length: 286  Bit Score: 65.65  E-value: 5.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632  39 IPPPQLSPALNSWRTSGhfftfRGNDIFYKEsvgvvGSSDVLVLLHGFPTSSYDWYKIWDSLTQRFnRVIALDFLGFGFS 118
Cdd:PRK03204    6 TPDPQLYPFESRWFDSS-----RGRIHYIDE-----GTGPPILLCHGNPTWSFLYRDIIVALRDRF-RCVAPDYLGFGLS 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1037195632 119 DKPRPHRYSIFEQASVVEALVAHLGLseQRINILSHDYGDTVAL 162
Cdd:PRK03204   75 ERPSGFGYQIDEHARVIGEFVDHLGL--DRYLSMGQDWGGPISM 116
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 53-342 5.62e-23

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 95.07  E-value: 5.62e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632  53 TSGHFFTFRGNDIFYKESvGVVGssDVLVLLHGFPTSSYDWYKIWDSLTQRFnRVIALDFLGFGFSDKPRPHrYSIFEQA 132
Cdd:COG0596     2 STPRFVTVDGVRLHYREA-GPDG--PPVVLLHGLPGSSYEWRPLIPALAAGY-RVIAPDLRGHGRSDKPAGG-YTLDDLA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632 133 SVVEALVAHLGLseQRINILSHDYGDTVALELLYRSDHNrsghiiVNSLCLSNGGIfpethhpRFLQKVLKDSGFISPVL 212
Cdd:COG0596    77 DDLAALLDALGL--ERVVLVGHSMGGMVALELAARHPER------VAGLVLVDEVL-------AALAEPLRRPGLAPEAL 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632 213 TRLMnfqlfsrgikevfgpyTQPTEAEVWDMWTGIRfndgnlvmdsllqyinqrlkhrerwvgaltstlTPLHMIYGPLD 292
Cdd:COG0596   142 AALL----------------RALARTDLRERLARIT---------------------------------VPTLVIWGEKD 172

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1037195632 293 PVNPhPQFLQLYQKLVQRSTVSVLdEHVSHYPQLEDPTGFFNAYLSFINS 342
Cdd:COG0596   173 PIVP-PALARRLAELLPNAELVVL-PGAGHFPPLEQPEAFAAALRDFLAR 220
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 78-329 4.82e-18

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 82.17  E-value: 4.82e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632  78 DVLVLLHGFPTSSYDWYKIWDSLTQRFNRVIALDFLGFGFSDKPR-PHRYSIFEQASVVEALVAHLGLseQRINILSHDY 156
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRPKaQDDYRTDDLAEDLEYILEALGL--EKVNLVGHSM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632 157 GDTVALELLYRSDHNRSGHIIVNSLCLSNGGIFPETH----HPRFLQKVLkdSGFISPVLTRLMNFQLfsrgikevfGPY 232
Cdd:pfam00561  79 GGLIALAYAAKYPDRVKALVLLGALDPPHELDEADRFilalFPGFFDGFV--ADFAPNPLGRLVAKLL---------ALL 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632 233 TQPTEAE------VWDMWTGIRFNDGNLVMDSLLQYINQRLKHRERWVGALTStltPLHMIYGPLDPVNPhPQFLQLYQK 306
Cdd:pfam00561 148 LLRLRLLkalpllNKRFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRLDE---PTLIIWGDQDPLVP-PQALEKLAQ 223

                         250       260
                  ....*....|....*....|...
gi 1037195632 307 LVQRSTVsVLDEHVSHYPQLEDP 329
Cdd:pfam00561 224 LFPNARL-VVIPDAGHFAFLEGP 245
PRK03204 PRK03204
haloalkane dehalogenase; Provisional
 39-162 5.06e-12

haloalkane dehalogenase; Provisional


Pssm-ID: 179554 [Multi-domain]  Cd Length: 286  Bit Score: 65.65  E-value: 5.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632  39 IPPPQLSPALNSWRTSGhfftfRGNDIFYKEsvgvvGSSDVLVLLHGFPTSSYDWYKIWDSLTQRFnRVIALDFLGFGFS 118
Cdd:PRK03204    6 TPDPQLYPFESRWFDSS-----RGRIHYIDE-----GTGPPILLCHGNPTWSFLYRDIIVALRDRF-RCVAPDYLGFGLS 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1037195632 119 DKPRPHRYSIFEQASVVEALVAHLGLseQRINILSHDYGDTVAL 162
Cdd:PRK03204   75 ERPSGFGYQIDEHARVIGEFVDHLGL--DRYLSMGQDWGGPISM 116
PRK03592 PRK03592
haloalkane dehalogenase; Provisional
 62-157 3.05e-11

haloalkane dehalogenase; Provisional


Pssm-ID: 235135  Cd Length: 295  Bit Score: 63.09  E-value: 3.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632  62 GNDIFYKESvgvvGSSDVLVLLHGFPTSSYDWYKIWDSLTQRfNRVIALDFLGFGFSDKPrPHRYSIFEQASVVEALVAH 141
Cdd:PRK03592   16 GSRMAYIET----GEGDPIVFLHGNPTSSYLWRNIIPHLAGL-GRCLAPDLIGMGASDKP-DIDYTFADHARYLDAWFDA 89

                          90
                  ....*....|....*.
gi 1037195632 142 LGLseQRINILSHDYG 157
Cdd:PRK03592   90 LGL--DDVVLVGHDWG 103
PLN03084 PLN03084
alpha/beta hydrolase fold protein; Provisional
 66-170 7.35e-11

alpha/beta hydrolase fold protein; Provisional


Pssm-ID: 178633  Cd Length: 383  Bit Score: 62.59  E-value: 7.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632  66 FYKESvgvvGSSD--VLVLLHGFPTSSYDWYKIWDSLTQRFnRVIALDFLGFGFSDKPRP---HRYSIFEQASVVEALVA 140
Cdd:PLN03084  118 FCVES----GSNNnpPVLLIHGFPSQAYSYRKVLPVLSKNY-HAIAFDWLGFGFSDKPQPgygFNYTLDEYVSSLESLID 192

                          90       100       110
                  ....*....|....*....|....*....|
gi 1037195632 141 HlgLSEQRINILSHDYGDTVALEllYRSDH 170
Cdd:PLN03084  193 E--LKSDKVSLVVQGYFSPPVVK--YASAH 218
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 56-123 2.94e-08

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 54.36  E-value: 2.94e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1037195632  56 HFFTFRGNDIFYKESVGvvgSSDVLVLLHGFPTSSYDWYKIWDSLTQRfNRVIALDFLGFGFSDKPRP 123
Cdd:PLN02824   11 RTWRWKGYNIRYQRAGT---SGPALVLVHGFGGNADHWRKNTPVLAKS-HRVYAIDLLGYGYSDKPNP 74
PLN02578 PLN02578
hydrolase
 29-342 4.00e-07

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 50.99  E-value: 4.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632  29 CVPLLAVYLHIPPPQLSPALnSWRTSGH-FFTFRGNDIFYKesvgVVGSSDVLVLLHGFPTSSYDW-YKIwDSLTQRFnR 106
Cdd:PLN02578   42 GVSVMGSSSASQSVQGLERL-PFKKEGYnFWTWRGHKIHYV----VQGEGLPIVLIHGFGASAFHWrYNI-PELAKKY-K 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632 107 VIALDFLGFGFSDKP----------------------RPH--------RYSIFEQASVVEALVAHLGL--------SEQR 148
Cdd:PLN02578  115 VYALDLLGFGWSDKAlieydamvwrdqvadfvkevvkEPAvlvgnslgGFTALSTAVGYPELVAGVALlnsagqfgSESR 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632 149 INILSHDYGDTVALELLYRSDHNRSGHIIVnslclsnGGIFPETHHPRFLQKVLK----DSGFISPVLtrlmnfqlfsrg 224
Cdd:PLN02578  195 EKEEAIVVEETVLTRFVVKPLKEWFQRVVL-------GFLFWQAKQPSRIESVLKsvykDKSNVDDYL------------ 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632 225 IKEVFGPYTQPTEAEV-WDMWTGIRFNDGNLVMDSLLqyinqrlkhrerwvgaltSTLT-PLHMIYGPLDPVNPhPQFLQ 302
Cdd:PLN02578  256 VESITEPAADPNAGEVyYRLMSRFLFNQSRYTLDSLL------------------SKLScPLLLLWGDLDPWVG-PAKAE 316

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1037195632 303 LYQKLVQRSTVSVLdeHVSHYPQLEDPTGFFNAYLSFINS 342
Cdd:PLN02578  317 KIKAFYPDTTLVNL--QAGHCPHDEVPEQVNKALLEWLSS 354
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 78-164 1.14e-06

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 49.58  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632  78 DVLVLLHGFPTSSYDWYKIWDSLTQRFNRVIALDFLGFGFSDKP-RPHRYSIFEQASVVEALVAHLGLSEqrINILSHDY 156
Cdd:PRK00870   47 PPVLLLHGEPSWSYLYRKMIPILAAAGHRVIAPDLIGFGRSDKPtRREDYTYARHVEWMRSWFEQLDLTD--VTLVCQDW 124


                  ....*...
gi 1037195632 157 GDTVALEL 164
Cdd:PRK00870  125 GGLIGLRL 132
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 80-210 5.43e-06

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 46.70  E-value: 5.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632  80 LVLLHGFPtssYDWYKIWDSLTQRFnRVIALDFLGFGFSDKPRPHrysiFEQASVVEALVAHLGLSEQRInILSHDYGDT 159
Cdd:pfam12697   1 VVLVHGAG---LSAAPLAALLAAGV-AVLAPDLPGHGSSSPPPLD----LADLADLAALLDELGAARPVV-LVGHSLGGA 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1037195632 160 VALELLyrsDHNRSGHIIVNSLCLSNGGIFPETHHPRFLQKVLKDSGFISP 210
Cdd:pfam12697  72 VALAAA---AAALVVGVLVAPLAAPPGLLAALLALLARLGAALAAPAWLAA 119
PRK05855 PRK05855
SDR family oxidoreductase;
80-169 1.34e-05

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 46.90  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632  80 LVLLHGFPTSSYDWYKIWDSLTQRFnRVIALDFLGFGFSDKPRPHRYSIFEQ-----ASVVEALVAhlglsEQRINILSH 154
Cdd:PRK05855   28 VVLVHGYPDNHEVWDGVAPLLADRF-RVVAYDVRGAGRSSAPKRTAAYTLARladdfAAVIDAVSP-----DRPVHLLAH 101

                          90
                  ....*....|....*
gi 1037195632 155 DYGDTVALELLYRSD 169
Cdd:PRK05855  102 DWGSIQGWEAVTRPR 116
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
52-170 1.46e-05

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 45.38  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632  52 RTSGHFFTFRGNDIFYKESVGVVGSSDVLVLLHGFPTSSYDWykiwDSLTQRFNR----VIALDFLGFGFSDKPRPHRYS 127
Cdd:COG2267     3 RRLVTLPTRDGLRLRGRRWRPAGSPRGTVVLVHGLGEHSGRY----AELAEALAAagyaVLAFDLRGHGRSDGPRGHVDS 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1037195632 128 IFEQASVVEALVAHLG-LSEQRINILSHDYGDTVALELLYRSDH 170
Cdd:COG2267    79 FDDYVDDLRAALDALRaRPGLPVVLLGHSMGGLIALLYAARYPD 122
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
79-165 7.90e-04

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 40.39  E-value: 7.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632  79 VLVLLHGFPTSSYDWYKIW-DSLTQR-FNrVIALDFLGFGFSDKpRPHRYSIFEQASVVEALVAHLGLSEQRINILSHDY 156
Cdd:COG1506    25 VVVYVHGGPGSRDDSFLPLaQALASRgYA-VLAPDYRGYGESAG-DWGGDEVDDVLAAIDYLAARPYVDPDRIGIYGHSY 102


                  ....*....
gi 1037195632 157 GDTVALELL 165
Cdd:COG1506   103 GGYMALLAA 111
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 80-121 8.10e-04

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 41.05  E-value: 8.10e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1037195632  80 LVLLHGFPTSSYDWYKIWDSLTQRFnRVIALDFLGFGFSDKP 121
Cdd:PLN02894  108 LVMVHGYGASQGFFFRNFDALASRF-RVIAIDQLGWGGSSRP 148
PLN02679 PLN02679
hydrolase, alpha/beta fold family protein
 66-128 1.77e-03

hydrolase, alpha/beta fold family protein


Pssm-ID: 178283 [Multi-domain]  Cd Length: 360  Bit Score: 39.82  E-value: 1.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1037195632  66 FYKESVGVVGSSDVLVLLHGFPTSSYDWYKIWDSLTQRFNrVIALDFLGFGFSDKPRPHRYSI 128
Cdd:PLN02679   77 LVKGSPEVTSSGPPVLLVHGFGASIPHWRRNIGVLAKNYT-VYAIDLLGFGASDKPPGFSYTM 138
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 62-191 2.17e-03

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 39.54  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632  62 GNDIFYKESvGVvGSSDVLVLLHGFPTSSYDWYKIWDSLtQRFNRVIALDFLGFGFSDKpRPHRYSIFEQASVVEALVAH 141
Cdd:PRK14875  118 GRTVRYLRL-GE-GDGTPVVLIHGFGGDLNNWLFNHAAL-AAGRPVIALDLPGHGASSK-AVGAGSLDELAAAVLAFLDA 193

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1037195632 142 LGLseQRINILSHDYGDTVALELLyrsdhnRSGHIIVNSLCL-SNGGIFPE 191
Cdd:PRK14875  194 LGI--ERAHLVGHSMGGAVALRLA------ARAPQRVASLTLiAPAGLGPE 236
PLN03087 PLN03087
BODYGUARD 1 domain containing hydrolase; Provisional
 78-164 3.43e-03

BODYGUARD 1 domain containing hydrolase; Provisional


Pssm-ID: 215567  Cd Length: 481  Bit Score: 39.02  E-value: 3.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632  78 DVLvLLHGFPTSSYDWYK-----IWDSLTQRFnRVIALDFLGFGFSDKPRPHRYSIFEQASVVEALVahlgLSEQRI--- 149
Cdd:PLN03087  203 DVL-FIHGFISSSAFWTEtlfpnFSDAAKSTY-RLFAVDLLGFGRSPKPADSLYTLREHLEMIERSV----LERYKVksf 276

                          90
                  ....*....|....*
gi 1037195632 150 NILSHDYGDTVALEL 164
Cdd:PLN03087  277 HIVAHSLGCILALAL 291
PLN02980 PLN02980
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ...
 71-179 6.89e-03

2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding


Pssm-ID: 215530 [Multi-domain]  Cd Length: 1655  Bit Score: 38.30  E-value: 6.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1037195632   71 VGVVGSSDVLVLLHGFPTSSYDWYKIWDSLTQRfNRVIALDFLGFGFSdKPRPHRYSIFEQASVVEALVAHL------GL 144
Cdd:PLN02980  1365 VGQNAEGSVVLFLHGFLGTGEDWIPIMKAISGS-ARCISIDLPGHGGS-KIQNHAKETQTEPTLSVELVADLlyklieHI 1442

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1037195632  145 SEQRINILSHDYGDTVALELLYRSDHNRSGHIIVN 179
Cdd:PLN02980  1443 TPGKVTLVGYSMGARIALYMALRFSDKIEGAVIIS 1477
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH