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Conserved domains on  [gi|1036551274|ref|NP_001315446|]
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notchless protein homolog 1 [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12087049)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
77-475 3.59e-106

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 321.48  E-value: 3.59e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274  77 QVLPVVYQPQAVFRVRAVARCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHHTSRGHTHWVLSIAWS 156
Cdd:COG2319    50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 157 PDGKKLASGCKNSQIFLWDPVTGKQIgKTLTGHTKWITWLCWeplhlNPECRYLASTSKDCTIRIWDTVLGHYDKILTGH 236
Cdd:COG2319   130 PDGKTLASGSADGTVRLWDLATGKLL-RTLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 237 THSVTCVKWGGDG-LLYTSSQDRTIKVWRAKDGVQCRTLQGHAHWVNTLALSTDyvlrtgafepanatinpqdltgslee 315
Cdd:COG2319   204 TGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD-------------------------- 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 316 ikekalkrynsvrgeGHeRLVSGSDDFTMFLWNpAEDKKPVARLTGHQALVNEVLFSPDTRLIASASFDKSIKIWDGKTG 395
Cdd:COG2319   258 ---------------GR-LLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 396 KYLNSLRGHVGPVYQVAWSADSRLLVSGSSDSTLKVWDIKTGKLNADLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWR 475
Cdd:COG2319   321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 8-68 3.02e-15

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


:

Pssm-ID: 462380  Cd Length: 66  Bit Score: 70.24  E-value: 3.02e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1036551274   8 VLIQLQDEAGE--VLGSPFDVPLDISPDKLQLVCNALLQKEE---PVPFLFFVKDAELVSSLGSCI 68
Cdd:pfam08154   1 VQVRFVTKEGElaVPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
77-475 3.59e-106

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 321.48  E-value: 3.59e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274  77 QVLPVVYQPQAVFRVRAVARCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHHTSRGHTHWVLSIAWS 156
Cdd:COG2319    50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 157 PDGKKLASGCKNSQIFLWDPVTGKQIgKTLTGHTKWITWLCWeplhlNPECRYLASTSKDCTIRIWDTVLGHYDKILTGH 236
Cdd:COG2319   130 PDGKTLASGSADGTVRLWDLATGKLL-RTLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 237 THSVTCVKWGGDG-LLYTSSQDRTIKVWRAKDGVQCRTLQGHAHWVNTLALSTDyvlrtgafepanatinpqdltgslee 315
Cdd:COG2319   204 TGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD-------------------------- 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 316 ikekalkrynsvrgeGHeRLVSGSDDFTMFLWNpAEDKKPVARLTGHQALVNEVLFSPDTRLIASASFDKSIKIWDGKTG 395
Cdd:COG2319   258 ---------------GR-LLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 396 KYLNSLRGHVGPVYQVAWSADSRLLVSGSSDSTLKVWDIKTGKLNADLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWR 475
Cdd:COG2319   321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 97-433 8.67e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 267.66  E-value: 8.67e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274  97 CTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHHTSRGHTHWVLSIAWSPDGKKLASGCKNSQIFLWDP 176
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 177 VTGKQIgKTLTGHTKWITWLCWeplhlNPECRYLASTSKDCTIRIWDTVLGHYDKILTGHTHSVTCVKWGGDG-LLYTSS 255
Cdd:cd00200    81 ETGECV-RTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 256 QDRTIKVWRAKDGVQCRTLQGHAHWVNTLALSTDyvlrtgafepanatinpqdltgsleeikekalkrynsvrgegHERL 335
Cdd:cd00200   155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD------------------------------------------GEKL 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 336 VSGSDDFTMFLWNPAEdKKPVARLTGHQALVNEVLFSPDTRLIASASFDKSIKIWDGKTGKYLNSLRGHVGPVYQVAWSA 415
Cdd:cd00200   193 LSSSSDGTIKLWDLST-GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271

                         330
                  ....*....|....*...
gi 1036551274 416 DSRLLVSGSSDSTLKVWD 433
Cdd:cd00200   272 DGKRLASGSADGTIRIWD 289
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 8-68 3.02e-15

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 70.24  E-value: 3.02e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1036551274   8 VLIQLQDEAGE--VLGSPFDVPLDISPDKLQLVCNALLQKEE---PVPFLFFVKDAELVSSLGSCI 68
Cdd:pfam08154   1 VQVRFVTKEGElaVPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
PTZ00421 PTZ00421
coronin; Provisional
 305-447 5.71e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 61.45  E-value: 5.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 305 NPQDLTGSLEEIKEKALKRYNSvrgeghERLVSGSDDFTMFLWN-PAEDKK-----PVARLTGHQALVNEVLFSPDTR-L 377
Cdd:PTZ00421   67 NPPILLGQEGPIIDVAFNPFDP------QKLFTASEDGTIMGWGiPEEGLTqnisdPIVHLQGHTKKVGIVSFHPSAMnV 140

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 378 IASASFDKSIKIWDGKTGKYLNSLRGHVGPVYQVAWSADSRLLVSGSSDSTLKVWDIKTGKLNADLPGHA 447
Cdd:PTZ00421  141 LASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 394-433 6.27e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 6.27e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1036551274  394 TGKYLNSLRGHVGPVYQVAWSADSRLLVSGSSDSTLKVWD 433
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
96-133 2.63e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 2.63e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1036551274  96 RCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWD 133
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 105-182 6.81e-05

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 44.96  E-value: 6.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 105 TEAVISVAFSPTGKYLA---SGSGDTTVRFWDLSTETPHHTS--RGHthwVLSIAWSPDGKKLA---SGCKNSQIFLWDp 176
Cdd:TIGR02800 189 REPILSPAWSPDGQKLAyvsFESGKPEIYVQDLATGQREKVAsfPGM---NGAPAFSPDGSKLAvslSKDGNPDIYVMD- 264


                  ....*.
gi 1036551274 177 VTGKQI 182
Cdd:TIGR02800 265 LDGKQL 270
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
77-475 3.59e-106

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 321.48  E-value: 3.59e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274  77 QVLPVVYQPQAVFRVRAVARCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHHTSRGHTHWVLSIAWS 156
Cdd:COG2319    50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 157 PDGKKLASGCKNSQIFLWDPVTGKQIgKTLTGHTKWITWLCWeplhlNPECRYLASTSKDCTIRIWDTVLGHYDKILTGH 236
Cdd:COG2319   130 PDGKTLASGSADGTVRLWDLATGKLL-RTLTGHSGAVTSVAF-----SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 237 THSVTCVKWGGDG-LLYTSSQDRTIKVWRAKDGVQCRTLQGHAHWVNTLALSTDyvlrtgafepanatinpqdltgslee 315
Cdd:COG2319   204 TGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPD-------------------------- 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 316 ikekalkrynsvrgeGHeRLVSGSDDFTMFLWNpAEDKKPVARLTGHQALVNEVLFSPDTRLIASASFDKSIKIWDGKTG 395
Cdd:COG2319   258 ---------------GR-LLASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 396 KYLNSLRGHVGPVYQVAWSADSRLLVSGSSDSTLKVWDIKTGKLNADLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWR 475
Cdd:COG2319   321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
96-436 1.66e-93

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 289.12  E-value: 1.66e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274  96 RCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHHTSRGHTHWVLSIAWSPDGKKLASGCKNSQIFLWD 175
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 176 PVTGKQIgKTLTGHTKWITWLCWeplhlNPECRYLASTSKDCTIRIWDTVLGHYDKILTGHTHSVTCVKWGGDG-LLYTS 254
Cdd:COG2319   191 LATGKLL-RTLTGHTGAVRSVAF-----SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLASG 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 255 SQDRTIKVWRAKDGVQCRTLQGHAHWVNTLALSTDyvlrtgafepanatinpqdltgsleeikekalkrynsvrgeGhER 334
Cdd:COG2319   265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-----------------------------------------G-KL 302

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 335 LVSGSDDFTMFLWNpAEDKKPVARLTGHQALVNEVLFSPDTRLIASASFDKSIKIWDGKTGKYLNSLRGHVGPVYQVAWS 414
Cdd:COG2319   303 LASGSDDGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                         330       340
                  ....*....|....*....|..
gi 1036551274 415 ADSRLLVSGSSDSTLKVWDIKT 436
Cdd:COG2319   382 PDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
87-475 1.95e-90

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 281.03  E-value: 1.95e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274  87 AVFRVRAVARCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHHTSRGHTHWVLSIAWSPDGKKLASGC 166
Cdd:COG2319    18 LALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 167 KNSQIFLWDPVTGKQIGkTLTGHTKWITWLCWeplhlNPECRYLASTSKDCTIRIWDTVLGHYDKILTGHTHSVTCVKWG 246
Cdd:COG2319    98 ADGTVRLWDLATGLLLR-TLTGHTGAVRSVAF-----SPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 247 GDG-LLYTSSQDRTIKVWRAKDGVQCRTLQGHAHWVNTLALSTDyvlrtgafepanatinpqdltgsleeikekalkryn 325
Cdd:COG2319   172 PDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD------------------------------------ 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 326 svrgegHERLVSGSDDFTMFLWNpAEDKKPVARLTGHQALVNEVLFSPDTRLIASASFDKSIKIWDGKTGKYLNSLRGHV 405
Cdd:COG2319   216 ------GKLLASGSADGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS 288

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 406 GPVYQVAWSADSRLLVSGSSDSTLKVWDIKTGKLNADLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWR 475
Cdd:COG2319   289 GGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWD 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 97-433 8.67e-87

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 267.66  E-value: 8.67e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274  97 CTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHHTSRGHTHWVLSIAWSPDGKKLASGCKNSQIFLWDP 176
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 177 VTGKQIgKTLTGHTKWITWLCWeplhlNPECRYLASTSKDCTIRIWDTVLGHYDKILTGHTHSVTCVKWGGDG-LLYTSS 255
Cdd:cd00200    81 ETGECV-RTLTGHTSYVSSVAF-----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 256 QDRTIKVWRAKDGVQCRTLQGHAHWVNTLALSTDyvlrtgafepanatinpqdltgsleeikekalkrynsvrgegHERL 335
Cdd:cd00200   155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD------------------------------------------GEKL 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 336 VSGSDDFTMFLWNPAEdKKPVARLTGHQALVNEVLFSPDTRLIASASFDKSIKIWDGKTGKYLNSLRGHVGPVYQVAWSA 415
Cdd:cd00200   193 LSSSSDGTIKLWDLST-GKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271

                         330
                  ....*....|....*...
gi 1036551274 416 DSRLLVSGSSDSTLKVWD 433
Cdd:cd00200   272 DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 184-475 2.74e-68

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 219.90  E-value: 2.74e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 184 KTLTGHTKWITWLCWeplhlNPECRYLASTSKDCTIRIWDTVLGHYDKILTGHTHSVTCVKWGGDG-LLYTSSQDRTIKV 262
Cdd:cd00200     3 RTLKGHTGGVTCVAF-----SPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGtYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 263 WRAKDGVQCRTLQGHAHWVNTLALSTDyvlrtgafepanatinpqdltGSLeeikekalkrynsvrgegherLVSGSDDF 342
Cdd:cd00200    78 WDLETGECVRTLTGHTSYVSSVAFSPD---------------------GRI---------------------LSSSSRDK 115

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 343 TMFLWNpAEDKKPVARLTGHQALVNEVLFSPDTRLIASASFDKSIKIWDGKTGKYLNSLRGHVGPVYQVAWSADSRLLVS 422
Cdd:cd00200   116 TIKVWD-VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLS 194

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1036551274 423 GSSDSTLKVWDIKTGKLNADLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWR 475
Cdd:cd00200   195 SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
WD40 COG2319
WD40 repeat [General function prediction only];
112-475 3.44e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 202.45  E-value: 3.44e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 112 AFSPTGKYLASGSGDTTVRFWDLSTETPHHTSRGHTHWVLSIAWSPDGKKLASGCKNSQIFLWDPVTGKQIgKTLTGHTK 191
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL-ATLLGHTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 192 WITwlcwePLHLNPECRYLASTSKDCTIRIWDTVLGHYDKILTGHTHSVTCVKWGGDG-LLYTSSQDRTIKVWRAKDGVQ 270
Cdd:COG2319    80 AVL-----SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGkTLASGSADGTVRLWDLATGKL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 271 CRTLQGHAHWVNTLAlstdyvlrtgafepanatinpqdltgsleeikekalkrynsvrgegherlvsgsddftmflwnpa 350
Cdd:COG2319   155 LRTLTGHSGAVTSVA----------------------------------------------------------------- 169

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 351 edkkpvarltghqalvnevlFSPDTRLIASASFDKSIKIWDGKTGKYLNSLRGHVGPVYQVAWSADSRLLVSGSSDSTLK 430
Cdd:COG2319   170 --------------------FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1036551274 431 VWDIKTGKLNADLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWR 475
Cdd:COG2319   230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 96-264 3.89e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 177.91  E-value: 3.89e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274  96 RCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHHTSRGHTHWVLSIAWSPDGKKLASGCKNSQIFLWD 175
Cdd:cd00200   126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 176 PVTGKQIgKTLTGHTKWITWLCWeplhlNPECRYLASTSKDCTIRIWDTVLGHYDKILTGHTHSVTCVKWGGDG-LLYTS 254
Cdd:cd00200   206 LSTGKCL-GTLRGHENGVNSVAF-----SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASG 279

                         170
                  ....*....|
gi 1036551274 255 SQDRTIKVWR 264
Cdd:cd00200   280 SADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 355-474 2.50e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.15  E-value: 2.50e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 355 PVARLTGHQALVNEVLFSPDTRLIASASFDKSIKIWDGKTGKYLNSLRGHVGPVYQVAWSADSRLLVSGSSDSTLKVWDI 434
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1036551274 435 KTGKLNADLPGHADEVFAVDWSPDGQRVASGGKDKCLRIW 474
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW 120
NLE pfam08154
NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the ...
 8-68 3.02e-15

NLE (NUC135) domain; This domain is located N terminal to WD40 repeats. It is found in the microtubule-associated protein Swiss:Q12024.


Pssm-ID: 462380  Cd Length: 66  Bit Score: 70.24  E-value: 3.02e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1036551274   8 VLIQLQDEAGE--VLGSPFDVPLDISPDKLQLVCNALLQKEE---PVPFLFFVKDAELVSSLGSCI 68
Cdd:pfam08154   1 VQVRFVTKEGElaVPGTPLDVPVSLTRYQLSELVNSLLKNEElekPVPFDFLINGEFLRTSLEEHL 66
PTZ00421 PTZ00421
coronin; Provisional
 305-447 5.71e-10

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 61.45  E-value: 5.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 305 NPQDLTGSLEEIKEKALKRYNSvrgeghERLVSGSDDFTMFLWN-PAEDKK-----PVARLTGHQALVNEVLFSPDTR-L 377
Cdd:PTZ00421   67 NPPILLGQEGPIIDVAFNPFDP------QKLFTASEDGTIMGWGiPEEGLTqnisdPIVHLQGHTKKVGIVSFHPSAMnV 140

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 378 IASASFDKSIKIWDGKTGKYLNSLRGHVGPVYQVAWSADSRLLVSGSSDSTLKVWDIKTGKLNADLPGHA 447
Cdd:PTZ00421  141 LASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 394-433 6.27e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.24  E-value: 6.27e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1036551274  394 TGKYLNSLRGHVGPVYQVAWSADSRLLVSGSSDSTLKVWD 433
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 96-133 1.06e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 1.06e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1036551274   96 RCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWD 133
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
96-133 2.63e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 2.63e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1036551274  96 RCTSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWD 133
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 136-175 6.25e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 6.25e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1036551274  136 TETPHHTSRGHTHWVLSIAWSPDGKKLASGCKNSQIFLWD 175
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
395-433 1.25e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 1.25e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1036551274 395 GKYLNSLRGHVGPVYQVAWSADSRLLVSGSSDSTLKVWD 433
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 352-391 2.91e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 2.91e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1036551274  352 DKKPVARLTGHQALVNEVLFSPDTRLIASASFDKSIKIWD 391
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 436-474 2.96e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 49.62  E-value: 2.96e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1036551274  436 TGKLNADLPGHADEVFAVDWSPDGQRVASGGKDKCLRIW 474
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 359-473 7.96e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 54.51  E-value: 7.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 359 LTGHQALVNEVLFSP-DTRLIASASFDKSIKIWD-------GKTGKYLNSLRGHVGPVYQVAWSADSR-LLVSGSSDSTL 429
Cdd:PTZ00421   71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGipeegltQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVV 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1036551274 430 KVWDIKTGKLNADLPGHADEVFAVDWSPDGQRVASGGKDKCLRI 473
Cdd:PTZ00421  151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI 194
WD40 pfam00400
WD domain, G-beta repeat;
353-391 8.09e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 8.09e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1036551274 353 KKPVARLTGHQALVNEVLFSPDTRLIASASFDKSIKIWD 391
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 87-267 3.31e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.59  E-value: 3.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274  87 AVFRVRAVARCTSS---LEGHTEAVISVAFSP-TGKYLASGSGDTTVRFWDLSTE-------TPHHTSRGHTHWVLSIAW 155
Cdd:PTZ00421   54 AVLKHTDYGKLASNppiLLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSF 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 156 SPDGKK-LASGCKNSQIFLWDPVTGKQiGKTLTGHTKWITWLCWeplhlNPECRYLASTSKDCTIRIWDTVLGhyDKILT 234
Cdd:PTZ00421  134 HPSAMNvLASAGADMVVNVWDVERGKA-VEVIKCHSDQITSLEW-----NLDGSLLCTTSKDKKLNIIDPRDG--TIVSS 205

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1036551274 235 GHTHSVT----CVKWGGDGLLYT----SSQDRTIKVWRAKD 267
Cdd:PTZ00421  206 VEAHASAksqrCLWAKRKDLIITlgcsKSQQRQIMLWDTRK 246
WD40 pfam00400
WD domain, G-beta repeat;
437-474 3.96e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 3.96e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1036551274 437 GKLNADLPGHADEVFAVDWSPDGQRVASGGKDKCLRIW 474
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
138-175 5.97e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 5.97e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1036551274 138 TPHHTSRGHTHWVLSIAWSPDGKKLASGCKNSQIFLWD 175
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 178-223 6.43e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 6.43e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1036551274  178 TGKQIgKTLTGHTKWITWLCWeplhlNPECRYLASTSKDCTIRIWD 223
Cdd:smart00320   1 SGELL-KTLKGHTGPVTSVAF-----SPDGKYLASGSDDGTIKLWD 40
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 111-463 1.18e-06

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 51.19  E-value: 1.18e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274  111 VAFSPTGKYL--ASGSGDTTVRFWDL---------STETPHHtsrghthWVLSIAWSPDGKKLASgcknSQIFLWDPvtg 179
Cdd:COG4946    110 VGWTPDGKSVlfASNRGSPPSRSNQLytvpvdgglPERLPLP-------PAGDGSFSPDGKKLAY----TRIGREFR--- 175

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274  180 kqigktltgHTKwitwlcweplhlnpecRYLASTSKDctIRIWDTVLGHYDKIlTGHTHSVTCVKWGGDGLLYTSSQDRT 259
Cdd:COG4946    176 ---------TWK----------------RYRGGTAGD--IWIYDLGTGEFTRL-TDFGGNDRNPMWIGDRIYFLSDRDGT 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274  260 IKVWRA----KDGVQCRTLQGH-AHWvntlaLSTDYvlRTGAFEpANATINPQDLTGSleeiKEKALK-RYNSVRGEGHE 333
Cdd:COG4946    228 FNLYSYdpdgKDLRQLTHFKDFdVRF-----PSTDG--GRIVYE-QGGDLYLLDLASG----EPRKLNiTLAGDFPQRRP 295

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274  334 RLVSGSDDFTMF-----------------LWNPAEdKKPVARLTGHQAlVNE--VLFSPDTRLIASASfDKSikiwdGKT 394
Cdd:COG4946    296 RWVDVSGYLTSFalspdgkrvafeargevFTVPAE-KGPTRNLTNTPG-VRErlPAWSPDGKSIAYFS-DAS-----GEY 367

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274  395 GKYLNSLRGHVGP----------VYQVAWSADSRLLVSGSSDSTLKVWDIKTGKLN-ADLPGHADEVFAVDWSPDGQRVA 463
Cdd:COG4946    368 ELYIAPADGSGEPkqltlgdlgrVFNPVWSPDGKKIAFTDNRGRLWVVDLASGKVRkVDTDGYGDGISDLAWSPDSKWLA 447
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 355-437 1.31e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 355 PVARLTGHQALVNEVLFSPDTRLIASASFDKSIKIWDGKTGKYLNSLRGHVGPVYQVAW-SADSRLLVSGSSDSTLKVWD 433
Cdd:PLN00181  525 PVVELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWS 604


                  ....
gi 1036551274 434 IKTG 437
Cdd:PLN00181  605 INQG 608
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
375-466 3.14e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.15  E-value: 3.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 375 TRLIASASFDKSIKIWDGKTGKYLNSLRGHVGPvYQVAWSAD-SRLLVSGSSDSTLKVWDIKTGKLNADLPGhADEVFAV 453
Cdd:COG3391    80 RRLYVANSGSGRVSVIDLATGKVVATIPVGGGP-RGLAVDPDgGRLYVADSGNGRVSVIDTATGKVVATIPV-GAGPHGI 157

                          90
                  ....*....|....*
gi 1036551274 454 DWSPDGQR--VASGG 466
Cdd:COG3391   158 AVDPDGKRlyVANSG 172
WD40 pfam00400
WD domain, G-beta repeat;
184-223 3.85e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 3.85e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1036551274 184 KTLTGHTKWITWLCWeplhlNPECRYLASTSKDCTIRIWD 223
Cdd:pfam00400   5 KTLEGHTGSVTSLAF-----SPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 120-296 6.48e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.93  E-value: 6.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 120 LASGSGDTTVRFWD-----LSTETPHHTSRghtHWVLSIAwSPDGKKLASGCKNSQIFLWDPVTGKQIGktlTGHTKWIT 194
Cdd:PLN00181  548 VASSNFEGVVQVWDvarsqLVTEMKEHEKR---VWSIDYS-SADPTLLASGSDDGSVKLWSINQGVSIG---TIKTKANI 620

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 195 WLCWEPlhlNPECRYLASTSKDCTIRIWDTvlgHYDKI----LTGHTHSVTCVKWGGDGLLYTSSQDRTIKVW---RAKD 267
Cdd:PLN00181  621 CCVQFP---SESGRSLAFGSADHKVYYYDL---RNPKLplctMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsMSIS 694

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1036551274 268 GVQ---CRTLQGHAHWVNTLALS-TDYVLRTGA 296
Cdd:PLN00181  695 GINetpLHSFMGHTNVKNFVGLSvSDGYIATGS 727
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 227-263 7.39e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 7.39e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1036551274  227 GHYDKILTGHTHSVTCVKWGGDG-LLYTSSQDRTIKVW 263
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 150-278 7.59e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.35  E-value: 7.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 150 VLSIAWSP-DGKKLASGCKNSQIFLWD-PVTGKQIGKT-----LTGHTKWITWLCWEPLHLNpecrYLASTSKDCTIRIW 222
Cdd:PTZ00421   78 IIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGLTQNISdpivhLQGHTKKVGIVSFHPSAMN----VLASAGADMVVNVW 153

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1036551274 223 DTVLGHYDKILTGHTHSVTCVKWGGDG-LLYTSSQDRTIKVWRAKDGVQCRTLQGHA 278
Cdd:PTZ00421  154 DVERGKAVEVIKCHSDQITSLEWNLDGsLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 97-198 8.77e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 8.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274  97 CTssLEGHTEAVISVAFSPTGKyLASGSGDTTVRFWDLS------TETPHHTSRGHTHWVLSIAWSPDGKKLASGCKNSQ 170
Cdd:PLN00181  655 CT--MIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSmsisgiNETPLHSFMGHTNVKNFVGLSVSDGYIATGSETNE 731

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1036551274 171 IFLW----------------DPVTGKQIGKTltghTKWITWLCW 198
Cdd:PLN00181  732 VFVYhkafpmpvlsykfktiDPVSGLEVDDA----SQFISSVCW 771
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 439-475 1.18e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 1.18e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1036551274 439 LNADLPGHADEVFAVDWSPDGQRVASGGKDKCLRIWR 475
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD 37
WD40 pfam00400
WD domain, G-beta repeat;
231-263 1.26e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1036551274 231 KILTGHTHSVTCVKWGGDG-LLYTSSQDRTIKVW 263
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 335-434 3.81e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.23  E-value: 3.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 335 LVSGSDDFTMFLWNPAEDKKPVARLTghQALVNEVLFSPDT-RLIASASFDKSIKIWDGKTGKY-LNSLRGHVGPVYQVA 412
Cdd:PLN00181  591 LASGSDDGSVKLWSINQGVSIGTIKT--KANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVR 668

                          90       100
                  ....*....|....*....|..
gi 1036551274 413 WsADSRLLVSGSSDSTLKVWDI 434
Cdd:PLN00181  669 F-VDSSTLVSSSTDNTLKLWDL 689
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
331-469 4.26e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.07  E-value: 4.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 331 GHERLVSGSDDFTMFLWNPAeDKKPVARLTGHQALVNeVLFSPD-TRLIASASFDKSIKIWDGKTGKYLNSLRGHVGPvY 409
Cdd:COG3391    79 GRRLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRG-LAVDPDgGRLYVADSGNGRVSVIDTATGKVVATIPVGAGP-H 155

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1036551274 410 QVAWSADS-RLLVSGSSDST----LKVWDIKTGKLNADLPGhADEVFAVDWSPDGQR--VASGGKDK 469
Cdd:COG3391   156 GIAVDPDGkRLYVANSGSNTvsviVSVIDTATGKVVATIPV-GGGPVGVAVSPDGRRlyVANRGSNT 221
propeller_TolB TIGR02800
tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB ...
 105-182 6.81e-05

tol-pal system beta propeller repeat protein TolB; Members of this protein family are the TolB periplasmic protein of Gram-negative bacteria. TolB is part of the Tol-Pal (peptidoglycan-associated lipoprotein) multiprotein complex, comprising five envelope proteins, TolQ, TolR, TolA, TolB and Pal, which form two complexes. The TolQ, TolR and TolA inner-membrane proteins interact via their transmembrane domains. The {beta}-propeller domain of the periplasmic protein TolB is responsible for its interaction with Pal. TolB also interacts with the outer-membrane peptidoglycan-associated proteins Lpp and OmpA. TolA undergoes a conformational change in response to changes in the proton-motive force, and interacts with Pal in an energy-dependent manner. The C-terminal periplasmic domain of TolA also interacts with the N-terminal domain of TolB. The Tol-PAL system is required for bacterial outer membrane integrity. E. coli TolB is involved in the tonB-independent uptake of group A colicins (colicins A, E1, E2, E3 and K), and is necessary for the colicins to reach their respective targets after initial binding to the bacteria. It is also involved in uptake of filamentous DNA. Study of its structure suggest that the TolB protein might be involved in the recycling of peptidoglycan or in its covalent linking with lipoproteins. The Tol-Pal system is also implicated in pathogenesis of E. coli, Haemophilus ducreyi , Salmonella enterica and Vibrio cholerae, but the mechanism(s) is unclear. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274305 [Multi-domain]  Cd Length: 417  Bit Score: 44.96  E-value: 6.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 105 TEAVISVAFSPTGKYLA---SGSGDTTVRFWDLSTETPHHTS--RGHthwVLSIAWSPDGKKLA---SGCKNSQIFLWDp 176
Cdd:TIGR02800 189 REPILSPAWSPDGQKLAyvsFESGKPEIYVQDLATGQREKVAsfPGM---NGAPAFSPDGSKLAvslSKDGNPDIYVMD- 264


                  ....*.
gi 1036551274 177 VTGKQI 182
Cdd:TIGR02800 265 LDGKQL 270
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 365-474 7.39e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 7.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 365 LVNEVLFSPDTRLIASASFDKSIKIWDGKTgkYLNSLRGHVGPVYQVA---------WSADSRLLVSGSS-DSTLKVWDI 434
Cdd:PLN00181  485 LVCAIGFDRDGEFFATAGVNKKIKIFECES--IIKDGRDIHYPVVELAsrsklsgicWNSYIKSQVASSNfEGVVQVWDV 562

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1036551274 435 KTGKLNADLPGHADEVFAVDW-SPDGQRVASGGKDKCLRIW 474
Cdd:PLN00181  563 ARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLW 603
PTZ00420 PTZ00420
coronin; Provisional
 101-223 1.45e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.17  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 101 LEGHTEAVISVAFSPT-GKYLASGSGDTTVRFWdlstETPHHTSRghthwVLSIAwspdgkklasgcknsqiflwDPVTg 179
Cdd:PTZ00420   70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVW----EIPHNDES-----VKEIK--------------------DPQC- 119

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1036551274 180 kqigkTLTGHTKWITWLCWEPLHLNPECrylaSTSKDCTIRIWD 223
Cdd:PTZ00420  120 -----ILKGHKKKISIIDWNPMNYYIMC----SSGFDSFVNIWD 154
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 150-198 1.90e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.34  E-value: 1.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1036551274 150 VLSIAWSPDGKKLASGCKNSQIFLWDPVTGKQIgKTLTGHTKWITWLCW 198
Cdd:pfam12894  41 VTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV-HHFSAGSDLITCLGW 88
PTZ00420 PTZ00420
coronin; Provisional
 333-391 1.91e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.79  E-value: 1.91e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1036551274 333 ERLVSGSDDFTMFLWN-PAED------KKPVARLTGHQALVNEVLFSP-DTRLIASASFDKSIKIWD 391
Cdd:PTZ00420   88 EILASGSEDLTIRVWEiPHNDesvkeiKDPQCILKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIWD 154
PTZ00420 PTZ00420
coronin; Provisional
 353-438 2.84e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 2.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 353 KKPVARLTGHQALVNEVLFSP-DTRLIASASFDKSIKIWD--------GKTGKYLNSLRGHVGPVYQVAWSADSRLLVSG 423
Cdd:PTZ00420   64 KPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEiphndesvKEIKDPQCILKGHKKKISIIDWNPMNYYIMCS 143

                          90
                  ....*....|....*.
gi 1036551274 424 SS-DSTLKVWDIKTGK 438
Cdd:PTZ00420  144 SGfDSFVNIWDIENEK 159
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 98-156 3.41e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.57  E-value: 3.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1036551274  98 TSSLEGHTEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHHTSRGHTHWVLSIAWS 156
Cdd:pfam12894  31 TLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 369-456 4.49e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 4.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 369 VLFSPDTRLIASASFDKSI--------KIWDGktgkylnSLRGHVGPVYQVAWSADSRLLVSGSSDSTLKVWDIKTGKLN 440
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELllhrlnwqRVWTL-------SPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIV 73

                          90
                  ....*....|....*.
gi 1036551274 441 ADLPGHADEVFAVDWS 456
Cdd:pfam12894  74 HHFSAGSDLITCLGWG 89
PTZ00420 PTZ00420
coronin; Provisional
 401-474 7.25e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 7.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 401 LRGHVGPVYQVAWS-ADSRLLVSGSSDSTLKVWDIKTGKLNAD--------LPGHADEVFAVDWSPDGQRV-ASGGKDKC 470
Cdd:PTZ00420   70 LKGHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVKeikdpqciLKGHKKKISIIDWNPMNYYImCSSGFDSF 149


                  ....
gi 1036551274 471 LRIW 474
Cdd:PTZ00420  150 VNIW 153
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 358-463 1.92e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 38.88  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 358 RLTGHQALVNEVLFSPDTRLIA-SASFDKSIKIW----DGKTGKYL-NSLRGHVGPVyqvaWSADSRLLV-SGSSDSTLK 430
Cdd:COG0823    25 RLTNSPGIDTSPAWSPDGRRIAfTSDRGGGPQIYvvdaDGGEPRRLtFGGGYNASPS----WSPDGKRLAfVSRSDGRFD 100

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1036551274 431 VW--DIKTGKLNAdlpgHADEVFAVDWSPDGQRVA 463
Cdd:COG0823   101 IYvlDLDGGAPRR----LTDGPGSPSWSPDGRRIV 131
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 377-438 3.17e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.67  E-value: 3.17e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1036551274 377 LIASASFDKSIKIWDGKTGKYLNSLRGHVGPVYQVAWSADSRLLVSGSSDSTLKVWDIKTGK 438
Cdd:pfam20426  96 LISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGR 157
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 119-265 5.03e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 37.73  E-value: 5.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1036551274 119 YLASGSGDTTVRFWDLSTETPHHTSRgHTHWVLSIAWSPDGKKLA-----SGckNSQIFLWDPVTGKQigKTLTGHTKWi 193
Cdd:COG0823     3 FTLSRDGNSDIYVVDLDGGEPRRLTN-SPGIDTSPAWSPDGRRIAftsdrGG--GPQIYVVDADGGEP--RRLTFGGGY- 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1036551274 194 twlCWEPlHLNPECRYLASTS-KDCTIRIW-DTVLGHYDKILTGHTHSVTcvkWGGDG--LLYTSSQDRTIKVWRA 265
Cdd:COG0823    77 ---NASP-SWSPDGKRLAFVSrSDGRFDIYvLDLDGGAPRRLTDGPGSPS---WSPDGrrIVFSSDRGGRPDLYVV 145
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 102-163 5.13e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 39.64  E-value: 5.13e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1036551274  102 EGHTEAVISVAFSPTGKYLA----SGSGDTTVRFWDLSTETPHHTSRGHTHWVlSIAWSPDGKKLA 163
Cdd:COG4946    428 DGYGDGISDLAWSPDSKWLAyskpGPNQLSQIFLYDVETGKTVQLTDGRYDDG-SPAFSPDGKYLY 492
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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