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Conserved domains on  [gi|1025812248|ref|NP_001311365|]
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presenilin-associated rhomboid-like protein, mitochondrial isoform 3 [Homo sapiens]

Protein Classification

rhomboid family protein( domain architecture ID 229382)

rhomboid family protein may be a membrane-bound serine protease that catalyzes regulated intramembrane proteolysis, resulting in the release of functional polypeptides from their membrane anchors

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rhomboid super family cl21536
Rhomboid family; This family contains integral membrane proteins that are related to ...
 209-316 1.64e-18

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


The actual alignment was detected with superfamily member pfam01694:

Pssm-ID: 451297  Cd Length: 147  Bit Score: 81.11  E-value: 1.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025812248 209 MLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYVgkvATGRYGPSLGA------------ 276
Cdd:pfam01694  10 LITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYL---FSPLSTPSVGAsgaifgllgall 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1025812248 277 ------------------ALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGH 316
Cdd:pfam01694  87 vlgprnrillfgligallALLLFILLNLVLGLLPGNGVSNLAHLGGLLVGLLLGFILL 144
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 209-316 1.64e-18

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 81.11  E-value: 1.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025812248 209 MLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYVgkvATGRYGPSLGA------------ 276
Cdd:pfam01694  10 LITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYL---FSPLSTPSVGAsgaifgllgall 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1025812248 277 ------------------ALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGH 316
Cdd:pfam01694  87 vlgprnrillfgligallALLLFILLNLVLGLLPGNGVSNLAHLGGLLVGLLLGFILL 144
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 169-311 3.10e-16

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 75.67  E-value: 3.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025812248 169 VTGIIAANVLVFCLWRVpsLQRTMIRYFTSNPASKVLCSP--MLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFM 246
Cdd:COG0705     6 TLALIALNVLVFLLQLL--LGGELLNWLALVPARLLLGELwrLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSKRFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025812248 247 AVYLSAGVISNFVSYVgkVATGRYGPSLGA-------------------------ALKAI------IAMDTAGMILGWKF 295
Cdd:COG0705    84 LLYLLSGLGGGLLQLL--FSPGSGYPLVGAsgaifgllgallvlgprrrvlllfiPIPALlfllvwLLLGLLFGLLGGGG 161

                         170
                  ....*....|....*.
gi 1025812248 296 FDHAAHLGGALFGIWY 311
Cdd:COG0705   162 IAWEAHLGGLLAGLLL 177
 
Name Accession Description Interval E-value
Rhomboid pfam01694
Rhomboid family; This family contains integral membrane proteins that are related to ...
 209-316 1.64e-18

Rhomboid family; This family contains integral membrane proteins that are related to Drosophila rhomboid protein. Members of this family are found in bacteria and eukaryotes. Rhomboid promotes the cleavage of the membrane-anchored TGF-alpha-like growth factor Spitz, allowing it to activate the Drosophila EGF receptor. Analysis has shown that Rhomboid-1 is an intramembrane serine protease (EC:3.4.21.105). Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite.


Pssm-ID: 426384  Cd Length: 147  Bit Score: 81.11  E-value: 1.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025812248 209 MLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYVgkvATGRYGPSLGA------------ 276
Cdd:pfam01694  10 LITSMFLHAGWLHLLFNMLALLFFGGPLERILGSVRFLLLYLLSGIAGSLLSYL---FSPLSTPSVGAsgaifgllgall 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1025812248 277 ------------------ALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGH 316
Cdd:pfam01694  87 vlgprnrillfgligallALLLFILLNLVLGLLPGNGVSNLAHLGGLLVGLLLGFILL 144
GlpG COG0705
Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein ...
 169-311 3.10e-16

Membrane-associated serine protease, rhomboid family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440469 [Multi-domain]  Cd Length: 189  Bit Score: 75.67  E-value: 3.10e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025812248 169 VTGIIAANVLVFCLWRVpsLQRTMIRYFTSNPASKVLCSP--MLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFM 246
Cdd:COG0705     6 TLALIALNVLVFLLQLL--LGGELLNWLALVPARLLLGELwrLLTSMFLHGGFLHLLFNMLALWVFGPLLERRLGSKRFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1025812248 247 AVYLSAGVISNFVSYVgkVATGRYGPSLGA-------------------------ALKAI------IAMDTAGMILGWKF 295
Cdd:COG0705    84 LLYLLSGLGGGLLQLL--FSPGSGYPLVGAsgaifgllgallvlgprrrvlllfiPIPALlfllvwLLLGLLFGLLGGGG 161

                         170
                  ....*....|....*.
gi 1025812248 296 FDHAAHLGGALFGIWY 311
Cdd:COG0705   162 IAWEAHLGGLLAGLLL 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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