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Conserved domains on  [gi|1017384731|ref|NP_001309492|]
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Putative carbonic anhydrase-like protein 1 [Caenorhabditis elegans]

Protein Classification

carbonic anhydrase family protein( domain architecture ID 10123206)

carbonic anhydrase family protein similar to carbonic anhydrase, which catalyzes the reversible hydration of gaseous carbon dioxide to carbonic acid

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
alpha_CARP_X_XI_like cd03121
Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup ...
39-295 8.52e-149

Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP XI plays a role in the development of gastrointestinal stromal tumors.


:

Pssm-ID: 239395 [Multi-domain]  Cd Length: 256  Bit Score: 417.58  E-value: 8.52e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  39 GPHFWGLVEKDWWMCKKGRLQSPIDIQPDRLLFDASVKPVRLDK-LPVVSEFVNTGQMVRVRIGYSskkPSVNITSGPLY 117
Cdd:cd03121     1 GPSFWGLVNSAWNLCSKGRRQSPVDIEPSRLLFDPFLTPLRIDTgRKVSGTFYNTGRHVSFRPDKD---PVVNISGGPLS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 118 gYRYRVQRIDFHMGRKNENGSEHTINGRRFPMEVQLVAYNTDLYPNFTSASKSPHGIAILSVLVDFGPETNQELIKLTIA 197
Cdd:cd03121    78 -YRYRLEEIRLHFGREDEQGSEHTVNGQAFPGEVQLIHYNSELYPNFSEASKSPNGLVIVSLFVKIGETSNPELRRLTNR 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 198 TA--SISYKDQRVQLADFEPWRLLPFTRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLYLSMEGAEKVPV 275
Cdd:cd03121   157 DTitSIRYKGDAYFLQDLSIELLLPETDHYITYEGSLTSPGCHETVTWIILNKPIYITKEQMHSLRLLSQNSPSQEKAPM 236
                         250       260
                  ....*....|....*....|
gi 1017384731 276 APNFRKIQETNNRLVRTNIQ 295
Cdd:cd03121   237 SPNFRPVQPLNNRPVRTNIN 256
 
Name Accession Description Interval E-value
alpha_CARP_X_XI_like cd03121
Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup ...
39-295 8.52e-149

Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP XI plays a role in the development of gastrointestinal stromal tumors.


Pssm-ID: 239395 [Multi-domain]  Cd Length: 256  Bit Score: 417.58  E-value: 8.52e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  39 GPHFWGLVEKDWWMCKKGRLQSPIDIQPDRLLFDASVKPVRLDK-LPVVSEFVNTGQMVRVRIGYSskkPSVNITSGPLY 117
Cdd:cd03121     1 GPSFWGLVNSAWNLCSKGRRQSPVDIEPSRLLFDPFLTPLRIDTgRKVSGTFYNTGRHVSFRPDKD---PVVNISGGPLS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 118 gYRYRVQRIDFHMGRKNENGSEHTINGRRFPMEVQLVAYNTDLYPNFTSASKSPHGIAILSVLVDFGPETNQELIKLTIA 197
Cdd:cd03121    78 -YRYRLEEIRLHFGREDEQGSEHTVNGQAFPGEVQLIHYNSELYPNFSEASKSPNGLVIVSLFVKIGETSNPELRRLTNR 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 198 TA--SISYKDQRVQLADFEPWRLLPFTRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLYLSMEGAEKVPV 275
Cdd:cd03121   157 DTitSIRYKGDAYFLQDLSIELLLPETDHYITYEGSLTSPGCHETVTWIILNKPIYITKEQMHSLRLLSQNSPSQEKAPM 236
                         250       260
                  ....*....|....*....|
gi 1017384731 276 APNFRKIQETNNRLVRTNIQ 295
Cdd:cd03121   237 SPNFRPVQPLNNRPVRTNIN 256
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
30-288 9.13e-80

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 242.22  E-value: 9.13e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731   30 WSYDSDvfGGPHFWGLVEKDwwmCKKGRLQSPIDIQPDRLLFDASVKPVRLD-KLPVVSEFVNTGQMVRVRIgyssKKPS 108
Cdd:smart01057   1 WGYEGK--NGPEHWGKLDPP---FCGGKRQSPIDIVTAEAQYDPSLKPLKLSyDQPTAKRILNNGHTVQVNF----DDDG 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  109 VNITSGPLYGyRYRVQRIDFHMGRKNENGSEHTINGRRFPMEVQLVAYNTDlyPNFTSASKSPHGIAILSVLVDFGPETN 188
Cdd:smart01057  72 STLSGGPLPG-RYRLKQFHFHWGGSDSEGSEHTIDGKRFPLELHLVHYNSK--GSFSEAVSKPGGLAVVAVFFKVGAEEN 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  189 QELIKLTIATASISYKDQRVQLADFEPWRLLP-FTRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLYLsm 267
Cdd:smart01057 149 PALQAILDHLPLIKYKGQETELTPFDLSSLLPaSTRHYYTYNGSLTTPPCSEGVTWIVFKEPITISTEQLEKFRTLLP-- 226
                          250       260
                   ....*....|....*....|.
gi 1017384731  268 eGAEKVPVAPNFRKIQETNNR 288
Cdd:smart01057 227 -MEGNEPLVNNARPLQPLNGR 246
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
39-294 1.38e-75

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 231.77  E-value: 1.38e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  39 GPHFWGlveKDWWMCKkGRLQSPIDIQPDRLLFDASVKPVRL---DKLPVVSEFVNTGQMVRVRIGYSSKkpsVNITSGP 115
Cdd:pfam00194   2 GPEHWG---KVYPSCG-GKRQSPINIDTRKVRYDPSLPPLTFqgyDVPPGKNTLTNNGHTVQVSLDDGDP---STISGGP 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 116 LYGyRYRVQRIDFHMGRKNENGSEHTINGRRFPMEVQLVAYNTDlYPNFTSASKSPHGIAILSVLVDFGPETNQELIKLT 195
Cdd:pfam00194  75 LAT-RYRLVQFHFHWGSTDSRGSEHTIDGKRYPAELHIVHYNSK-YKSFDEAAKHPDGLAVLGVFFEVGDENNPYLQPIV 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 196 IATASISYKDQRVQLADFEPWRLLP-FTRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLYLSMEGAEKVP 274
Cdd:pfam00194 153 SALDNIKYKGKSVLLPPFDLSDLLPeDLTSYYTYNGSLTTPPCSESVTWIVFKEPISISEEQLEAFRTLLFSDGGEEPRP 232
                         250       260
                  ....*....|....*....|
gi 1017384731 275 VAPNFRKIQETNNRLVRTNI 294
Cdd:pfam00194 233 LVNNFRPTQPLNGRVVFASF 252
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
8-290 2.47e-41

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 143.49  E-value: 2.47e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731   8 FPLFLIILTCHISPLKSSQNYQWSYDSDvfGGPHFWGLVEKDWWMCKKGRLQSPIDIQPDRllfDASVKPVRLDKLPVVS 87
Cdd:COG3338     6 LLALLLAAALPAAAAAAASAPHWSYEGE--TGPEHWGELSPEFATCATGKNQSPIDIRTAI---KADLPPLKFDYKPTPL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  88 EFVNTGQMVRVRIGYSSkkpsvNITSGplyGYRYRVQRIDFHMGrknengSEHTINGRRFPMEVQLVayntdlypnftsa 167
Cdd:COG3338    81 EIVNNGHTIQVNVDPGS-----TLTVD---GKRYELKQFHFHTP------SEHTINGKSYPMEAHLV------------- 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 168 SKSPHG-IAILSVLVDFGPEtNQELIKLtIATASISYKDQRVQLADFEPWRLLPFTRDIITYEGSLTSPGCHETVTWIIL 246
Cdd:COG3338   134 HKDADGeLAVVGVLFEEGAE-NPALAKL-WANLPLEAGEEVALDATIDLNDLLPEDRSYYRYSGSLTTPPCSEGVLWIVL 211
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1017384731 247 NQPIFIKKEHFEEWSHLYlsmegaekvpvAPNFRKIQETNNRLV 290
Cdd:COG3338   212 KQPITVSAEQIEAFARLY-----------PNNARPVQPLNGRLI 244
PLN02179 PLN02179
carbonic anhydrase
30-245 1.01e-13

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 69.24  E-value: 1.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  30 WSYDSDVFGGPHFWGLVEKDWWMCKKGRLQSPIDIQPDR--LLFDASVKpvrLDKLPVVSEFVNTGQMVRVRIGYSSKKP 107
Cdd:PLN02179   37 FTYKQKTEKGPAEWGKLNPQWKVCSTGKYQSPIDLTDERvsLIHDQALS---RHYKPAPAVIQSRGHDVMVSWKGDAGKI 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 108 SVNITSgplygyrYRVQRIDFHmgrkneNGSEHTINGRRFPMEVQLVayntdlypnFTSASKSphgIAILSVLVDFGpET 187
Cdd:PLN02179  114 TIHQTD-------YKLVQCHWH------SPSEHTINGTSYDLELHMV---------HTSASGK---TAVVGVLYKLG-EP 167
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1017384731 188 NQELIKLTIATASISYKDqrVQLADFEPWRLLPFTRDIITYEGSLTSPGCHETVTWII 245
Cdd:PLN02179  168 DEFLTKLLNGIKGVGKKE--INLGIVDPRDIRFETNNFYRYIGSLTIPPCTEGVIWTV 223
 
Name Accession Description Interval E-value
alpha_CARP_X_XI_like cd03121
Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup ...
39-295 8.52e-149

Carbonic anhydrase alpha related protein: groups X, XI and related proteins. This subgroup contains carbonic anhydrase related proteins (CARPs) X and XI, which have been implicated in various biological processes of the central nervous system. CARPs are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP XI plays a role in the development of gastrointestinal stromal tumors.


Pssm-ID: 239395 [Multi-domain]  Cd Length: 256  Bit Score: 417.58  E-value: 8.52e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  39 GPHFWGLVEKDWWMCKKGRLQSPIDIQPDRLLFDASVKPVRLDK-LPVVSEFVNTGQMVRVRIGYSskkPSVNITSGPLY 117
Cdd:cd03121     1 GPSFWGLVNSAWNLCSKGRRQSPVDIEPSRLLFDPFLTPLRIDTgRKVSGTFYNTGRHVSFRPDKD---PVVNISGGPLS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 118 gYRYRVQRIDFHMGRKNENGSEHTINGRRFPMEVQLVAYNTDLYPNFTSASKSPHGIAILSVLVDFGPETNQELIKLTIA 197
Cdd:cd03121    78 -YRYRLEEIRLHFGREDEQGSEHTVNGQAFPGEVQLIHYNSELYPNFSEASKSPNGLVIVSLFVKIGETSNPELRRLTNR 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 198 TA--SISYKDQRVQLADFEPWRLLPFTRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLYLSMEGAEKVPV 275
Cdd:cd03121   157 DTitSIRYKGDAYFLQDLSIELLLPETDHYITYEGSLTSPGCHETVTWIILNKPIYITKEQMHSLRLLSQNSPSQEKAPM 236
                         250       260
                  ....*....|....*....|
gi 1017384731 276 APNFRKIQETNNRLVRTNIQ 295
Cdd:cd03121   237 SPNFRPVQPLNNRPVRTNIN 256
Carb_anhydrase smart01057
Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse ...
30-288 9.13e-80

Eukaryotic-type carbonic anhydrase; Carbonic anhydrases are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate.. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; they are also involved in many other processes, from respiration and photosynthesis in eukaryotes to cyanate degradation in prokaryotes. There are five known evolutionarily distinct CA families (alpha, beta, gamma, delta and epsilon) that have no significant sequence identity and have structurally distinct overall folds. Some CAs are membrane-bound, while others act in the cytosol; there are several related proteins that lack enzymatic activity. The active site of alpha-CAs is well described, consisting of a zinc ion coordinated through 3 histidine residues and a water molecule/hydroxide ion that acts as a potent nucleophile. The enzyme employs a two-step mechanism: in the first step, there is a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide; in the second step, the active site is regenerated by the ionisation of the zinc-bound water molecule and the removal of a proton from the active site. Beta- and gamma-CAs also employ a zinc hydroxide mechanism, although at least some beta-class enzymes do not have water directly coordinated to the metal ion.


Pssm-ID: 215000 [Multi-domain]  Cd Length: 247  Bit Score: 242.22  E-value: 9.13e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731   30 WSYDSDvfGGPHFWGLVEKDwwmCKKGRLQSPIDIQPDRLLFDASVKPVRLD-KLPVVSEFVNTGQMVRVRIgyssKKPS 108
Cdd:smart01057   1 WGYEGK--NGPEHWGKLDPP---FCGGKRQSPIDIVTAEAQYDPSLKPLKLSyDQPTAKRILNNGHTVQVNF----DDDG 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  109 VNITSGPLYGyRYRVQRIDFHMGRKNENGSEHTINGRRFPMEVQLVAYNTDlyPNFTSASKSPHGIAILSVLVDFGPETN 188
Cdd:smart01057  72 STLSGGPLPG-RYRLKQFHFHWGGSDSEGSEHTIDGKRFPLELHLVHYNSK--GSFSEAVSKPGGLAVVAVFFKVGAEEN 148
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  189 QELIKLTIATASISYKDQRVQLADFEPWRLLP-FTRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLYLsm 267
Cdd:smart01057 149 PALQAILDHLPLIKYKGQETELTPFDLSSLLPaSTRHYYTYNGSLTTPPCSEGVTWIVFKEPITISTEQLEKFRTLLP-- 226
                          250       260
                   ....*....|....*....|.
gi 1017384731  268 eGAEKVPVAPNFRKIQETNNR 288
Cdd:smart01057 227 -MEGNEPLVNNARPLQPLNGR 246
alpha_CA cd00326
Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are ...
56-291 4.24e-76

Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues and a fourth conserved histidine plays a potential role in proton transfer.


Pssm-ID: 238200  Cd Length: 227  Bit Score: 232.17  E-value: 4.24e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  56 GRLQSPIDIQPDRLLFDASVKPVRLDKLPVVS-EFVNTGQMVRVRIgyssKKPSVNITSGPLyGYRYRVQRIDFHMGRKN 134
Cdd:cd00326     1 GKRQSPINIVTSAVVYDPSLPPLNFDYYPTTSlTLVNNGHTVQVNF----DDDGGTLSGGGL-PGRYKLVQFHFHWGSEN 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 135 ENGSEHTINGRRFPMEVQLVAYNTDLYPNftSASKSPHGIAILSVLVDFGPETNQELIKLTIATASISYKDQRVQLADFE 214
Cdd:cd00326    76 SPGSEHTIDGKRYPLELHLVHYNSDYYSS--EAAKKPGGLAVLGVFFEVGEKENPFLKKILDALPKIKYKGKETTLPPFD 153
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1017384731 215 PWRLLP-FTRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLYLSmegaEKVPVAPNFRKIQETNNRLVR 291
Cdd:cd00326   154 LSDLLPsSLRDYYTYEGSLTTPPCSEGVTWIVFKEPITISKEQLEAFRSLLDR----EGKPLVNNYRPVQPLNGRVVY 227
Carb_anhydrase pfam00194
Eukaryotic-type carbonic anhydrase;
39-294 1.38e-75

Eukaryotic-type carbonic anhydrase;


Pssm-ID: 459707 [Multi-domain]  Cd Length: 252  Bit Score: 231.77  E-value: 1.38e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  39 GPHFWGlveKDWWMCKkGRLQSPIDIQPDRLLFDASVKPVRL---DKLPVVSEFVNTGQMVRVRIGYSSKkpsVNITSGP 115
Cdd:pfam00194   2 GPEHWG---KVYPSCG-GKRQSPINIDTRKVRYDPSLPPLTFqgyDVPPGKNTLTNNGHTVQVSLDDGDP---STISGGP 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 116 LYGyRYRVQRIDFHMGRKNENGSEHTINGRRFPMEVQLVAYNTDlYPNFTSASKSPHGIAILSVLVDFGPETNQELIKLT 195
Cdd:pfam00194  75 LAT-RYRLVQFHFHWGSTDSRGSEHTIDGKRYPAELHIVHYNSK-YKSFDEAAKHPDGLAVLGVFFEVGDENNPYLQPIV 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 196 IATASISYKDQRVQLADFEPWRLLP-FTRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLYLSMEGAEKVP 274
Cdd:pfam00194 153 SALDNIKYKGKSVLLPPFDLSDLLPeDLTSYYTYNGSLTTPPCSESVTWIVFKEPISISEEQLEAFRTLLFSDGGEEPRP 232
                         250       260
                  ....*....|....*....|
gi 1017384731 275 VAPNFRKIQETNNRLVRTNI 294
Cdd:pfam00194 233 LVNNFRPTQPLNGRVVFASF 252
alpha_CA_I_II_III_XIII cd03119
Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are ...
29-291 5.15e-53

Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozymes I, II, and III, which are cytoplasmic enzymes. CA I, for example, is expressed in erythrocyes of many vertebrates; CA II is the most active cytosolic isozyme; while it is being expressed nearly ubiquitously, it comprises 95% of the renal carbonic anhydrase and is required for renal acidification; CA III has been implicated in protection from the damaging effect of oxidizing agents in hepatocytes. CAXIII may play important physiological roles in several organs.


Pssm-ID: 239393 [Multi-domain]  Cd Length: 259  Bit Score: 174.16  E-value: 5.15e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  29 QWSYDSDvfGGPHFWglveKDWWMCKKGRLQSPIDIQPDRLLFDASVKPVRLDKLPVVS-EFVNTGQMVRVRIGYSSKKp 107
Cdd:cd03119     4 HWGYDSH--NGPEHW----HELFPIAKGDRQSPIDIKTKDAKHDPSLKPLSVSYDPATAkTILNNGHSFNVEFDDTDDR- 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 108 SVnITSGPLYGyRYRVQRIDFHMGRKNENGSEHTINGRRFPMEVQLVAYNTDlYPNFTSASKSPHGIAILSVLVDFGpET 187
Cdd:cd03119    77 SV-LRGGPLTG-SYRLRQFHFHWGSSDDHGSEHTVDGVKYAAELHLVHWNSK-YGSFGEAAKQPDGLAVVGVFLKVG-EA 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 188 NQELIKLTIATASISYKDQRVQLADFEPWRLLPFTRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLYLSM 267
Cdd:cd03119   153 NPELQKVLDALDSIKTKGKQAPFTNFDPSCLLPASLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQMAKFRSLLFNA 232
                         250       260
                  ....*....|....*....|....
gi 1017384731 268 EGAEKVPVAPNFRKIQETNNRLVR 291
Cdd:cd03119   233 EGEPPCPMVDNWRPPQPLKGRKVR 256
alpha_CA_VI_IX_XII_XIV cd03123
Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are ...
56-293 3.14e-52

Carbonic anhydrase alpha, isozymes VI, IX, XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are mostly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva, for example, and the membrane proteins CA IX, XII, and XIV.


Pssm-ID: 239397 [Multi-domain]  Cd Length: 248  Bit Score: 171.72  E-value: 3.14e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  56 GRLQSPIDIQPDRLLFDASVKPVRLD--KLPVVSEF--VNTGQMVRVrigysSKKPSVNITSGPlyGYRYRVQRIDFHMG 131
Cdd:cd03123    14 GKRQSPIDIQTDIVQFDPSLPPLELVgyDLPGTEEFtlTNNGHTVQL-----SLPPTMHIRGGP--GTEYTAAQLHLHWG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 132 RKNE-NGSEHTINGRRFPMEVQLVAYNTDLYPNFTSASKSPHGIAILSVLVDFGPETNQELIKLTIATASISYKDQRVQL 210
Cdd:cd03123    87 GRGSlSGSEHTIDGIRFAAELHIVHYNSDKYSSFDEAADKPDGLAVLAILIEVGYPENTYYEKIISHLHEIKYKGQETTV 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 211 ADFEPWRLLPF-TRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEwshLYLSMEGAEKVPVAPNFRKIQETNNRL 289
Cdd:cd03123   167 PGFNVRELLPEdLSHYYRYEGSLTTPPCYESVLWTVFRDPVTLSKEQLET---LENTLMDTHNKTLQNNYRATQPLNGRV 243

                  ....
gi 1017384731 290 VRTN 293
Cdd:cd03123   244 VEAS 247
alpha_CA_VII cd03149
Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are ...
56-291 8.85e-52

Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme VII. CA VII is the most active cytosolic enzyme after CA II, and may be highly expressed in the brain. Human CA VII may be a target of antiepileptic sulfonamides/sulfamates.


Pssm-ID: 239402  Cd Length: 236  Bit Score: 170.02  E-value: 8.85e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  56 GRLQSPIDIQPDRLLFDASVKPVRLDKLPVVS-EFVNTGQMVRVRIGYSSKKpSVnITSGPLYGyRYRVQRIDFHMGRKN 134
Cdd:cd03149     1 GNRQSPIDIVSSEAVYDPKLKPLSLSYDPCTSlSISNNGHSVMVEFDDSDDK-TV-ITGGPLEN-PYRLKQFHFHWGAKH 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 135 ENGSEHTINGRRFPMEVQLVAYNTDLYPNFTSASKSPHGIAILSVLVDFGPEtNQELIKLTIATASISYKDQRVQLADFE 214
Cdd:cd03149    78 GSGSEHTVDGKTFPSELHLVHWNAKKYKSFGEAAAAPDGLAVLGVFLETGDE-HPGLNRLTDALYMVRFKGTKAQFLDFN 156
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1017384731 215 PWRLLPFTRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLYLSMEGAEKVPVAPNFRKIQETNNRLVR 291
Cdd:cd03149   157 PKCLLPKSLDYWTYPGSLTTPPLNESVTWIVLKEPIPVSEKQMGKFRELLFTSEEDQRNHMVNNFRPPQPLKGRTVR 233
alpha_CA_V cd03118
Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are ...
56-293 1.56e-49

Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This vertebrate subgroup comprises isozyme V. CA V is the mitochondrial isozyme, which may play a role in gluconeogenesis and ureagenesis and possibly also in lipogenesis.


Pssm-ID: 239392  Cd Length: 236  Bit Score: 164.25  E-value: 1.56e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  56 GRLQSPIDIQPDRLLFDASVKPVRLDKLPVVSEFV-NTGQMVRVRIGYSSKKPSvnITSGPLyGYRYRVQRIDFHMGRKN 134
Cdd:cd03118     1 GTRQSPINIQWRDSVYDPQLAPLRVSYDPATCLYIwNNGYSFQVEFDDSTDKSG--ISGGPL-ENHYRLKQFHFHWGANN 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 135 ENGSEHTINGRRFPMEVQLVAYNTDLYPNFTSASKSPHGIAILSVLVDFGPEtNQELIKLTIATASISYKDQRVQLADFE 214
Cdd:cd03118    78 EWGSEHTVDGHTYPAELHLVHWNSVKYENFEEAVMEENGLAVIGVFLKLGAH-HEGLQKLVDALPEVRHKDTVVEFNPFD 156
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1017384731 215 PWRLLPFTRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLYLSMEGAEKVPVAPNFRKIQETNNRLVRTN 293
Cdd:cd03118   157 PSCLLPACRDYWTYPGSLTTPPLTESVTWIIQKQPIEVSPSQLSVFRTLLFTSRGEEEKVMVNNFRPLQPLMNRKVRSS 235
alpha_CA_XII_XIV cd03126
Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing ...
56-290 3.13e-46

Carbonic anhydrase alpha, isozymes XII and XIV. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane proteins CA XII and XIV.


Pssm-ID: 239400  Cd Length: 249  Bit Score: 156.15  E-value: 3.13e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  56 GRLQSPIDIQPDRLLFDASVKPVRLDKLPVVS----EFVNTGQMVRVrigysSKKPSVNITSGPlygYRYRVQRIDFHMG 131
Cdd:cd03126    14 GVAQSPIDIHTDILQYDSSLPPLEFHGYNVSGteqfTLTNNGHTVQL-----SLPPTMHIGGLP---FKYTASQLHLHWG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 132 RKNE-NGSEHTINGRRFPMEVQLVAYNTDLYPNFTSASKSPHGIAILSVLVDFGPEtNQELIKLTIATASISYKDQRVQL 210
Cdd:cd03126    86 QRGSpEGSEHTISGKHFAAELHIVHYNSDKYPDISTAMNKSQGLAVLGILIEVGPF-NPSYEKIFSHLHEVKYKDQKVSV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 211 ADFEPWRLLP-FTRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLYLSMEGAEKVPVAPNFRKIQETNNRL 289
Cdd:cd03126   165 PGFNVQELLPkRLDEYYRYEGSLTTPPCYPSVLWTVFRNPVQISQEQLLALETALYSTEEDESREMVNNYRQVQPFNERL 244

                  .
gi 1017384731 290 V 290
Cdd:cd03126   245 V 245
alpha_CARP_receptor_like cd03122
Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related ...
39-290 1.09e-44

Carbonic anhydrase alpha related protein, receptor_like subfamily. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. This sub-family of carbonic anhydrase-related domains found in tyrosine phosphatase receptors may play a role in cell adhesion.


Pssm-ID: 239396 [Multi-domain]  Cd Length: 253  Bit Score: 152.51  E-value: 1.09e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  39 GPHFWGLVEKDwwmCKKGRLQSPIDIQPDRLLFDASVKPVRLDKLPVVSE---FVNTGQMVRVRIGYSSKKPSvnITSGP 115
Cdd:cd03122     1 NPKHWAKKYPA---CGEGRQQSPIDIVEDTQVQRQGLQPLHFDGYEELTAsttLENTGKTVILRLEGNSSDPF--VSGGP 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 116 LYGyRYRVQRIDFHMGRKNENGSEHTINGRRFPMEVQLVAYNTDLYPNFTsASKSPHGIAILSVLVDFGPETNQELIKLT 195
Cdd:cd03122    76 LLG-RYKFSEITFHWGTCNSDGSEHSIDGHKFPLEMQILHRNTDFFDSFE-AIKSPGGVLALAYLFELSHEDNPFLDPII 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 196 IATASISYKDQRVQLADFEPWRLLP-FTRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLyLSMEGAEKVP 274
Cdd:cd03122   154 EGLRNVSRPGKEVELPPFPLSDLLPpFTDKYYSYEGSLTTPPCSETVEWIVFREPVPISSRQLEAFREL-LTRRQDGVMS 232
                         250
                  ....*....|....*....
gi 1017384731 275 VAP---NFRKIQETNNRLV 290
Cdd:cd03122   233 GDYlpnNGRPQQPLGSRTV 251
alpha_CARP_VIII cd03120
Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins ...
43-291 1.69e-44

Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism. CARPs have lost conserved histidines involved in zinc binding and consequently their catalytic activity. CARP VIII may play roles in various biological processes of the central nervous system, and could be involved in protein-protein interactions. CARP VIII has been shown to bind inositol 1,4,5-triphosphate (IP3) receptor type I (IP3RI), reducing the affinity of the receptor for IP3. IP3RI is an intracellular IP3-gated Ca2+ channel located on intracellular Ca2+ stores. IP3RI converts IP3 signaling into Ca2+ signaling thereby participating in a variety of cell functions.


Pssm-ID: 239394  Cd Length: 256  Bit Score: 151.93  E-value: 1.69e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  43 WGLVEKDwwmcKKGRLQSPIDIQPDRLLFDASVKPVRLDKLPVVS---EFVNTGQMVRVRIGYSSKkpsvnITSGPL-YG 118
Cdd:cd03120     4 WGLLFPE----ANGEYQSPINLNSREARYDPSLLEVRLSPNYVVCrdcEVINDGHTIQIILKSKSV-----LSGGPLpQG 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 119 YRYRVQRIDFHMGRKNENGSEHTINGRRFPMEVQLVAYNTDLYPNFTSASKSPHGIAILSVLVDFGPEtNQELIKLTIAT 198
Cdd:cd03120    75 HEFELAEVRFHWGRENQRGSEHTVNFKAFPMELHLIHWNSTLYSSLEEAMGKPHGIAIIALFVQIGKE-HVGLKAVTEIL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 199 ASISYKDQRVQLADFEPWRLL--PFTRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLYLSMEGAEKVPV- 275
Cdd:cd03120   154 QDIQYKGKSKTIPCFNPNTLLpdPLLRDYWVYEGSLTTPPCSEGVTWILFRYPLTISQSQIEEFRRLRTHVKGAELVEGc 233
                         250       260
                  ....*....|....*....|
gi 1017384731 276 ----APNFRKIQETNNRLVR 291
Cdd:cd03120   234 dgllGDNFRPTQPLSDRVIR 253
alpha_CA_IV_XV_like cd03117
Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are ...
56-290 3.48e-44

Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This subgroup, restricted to animals, contains isozyme IV and similar proteins such as mouse CA XV. Isozymes IV is attached to membranes via a glycosylphosphatidylinositol (GPI) tail. In mammals, Isozyme IV plays crucial roles in kidney and lung function, amongst others. This subgroup also contains the dual domain CA from the giant clam, Tridacna gigas. T. gigas CA plays a role in the movement of inorganic carbon from the surrounding seawater to the symbiotic algae found in the clam's tissues. CA XV is expressed in several species but not in humans or chimps. Similar to isozyme CA IV, CA XV attaches to membranes via a GPI tail.


Pssm-ID: 239391  Cd Length: 234  Bit Score: 150.50  E-value: 3.48e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  56 GRLQSPIDIQPDRLLFDASVKPVRLDKLPVVS---EFVNTGQMVRVRIgysskKPSVNITSGPLYGyRYRVQRIDFHMGR 132
Cdd:cd03117     1 GKRQSPINIVTKKVQYDENLTPFTFTGYDDTTtnwTITNNGHTVQVTL-----PDGAKISGGGLPG-TYKALQFHFHWGS 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 133 KNENGSEHTINGRRFPMEVQLVAYNTDlYPNFTSASKSPHGIAILSVLVDFGPETNQELIKLTIATASISYKDQRVQLAD 212
Cdd:cd03117    75 NGSPGSEHTIDGERYPMELHIVHIKES-YNSLLEALKDSDGLAVLGFFIEEGEEENTNFDPLISALSNIPQKGGSTNLTP 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 213 F------EPWRLLPFTRdiitYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLYLSMEgAEKVPVAPNFRKIQETN 286
Cdd:cd03117   154 FslrsllPSVLLTKYYR----YNGSLTTPGCNEAVIWTVFEEPIPISRAQLDAFSTVLFFDT-DNGQPMVNNFRPVQPLN 228

                  ....
gi 1017384731 287 NRLV 290
Cdd:cd03117   229 GRVV 232
alpha_CA_prokaryotic_like cd03124
Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are ...
39-290 1.60e-42

Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidines. This sub-family includes bacterial carbonic anhydrase alpha, as well as plant enzymes such as tobacco nectarin III and yam dioscorin and, carbonic anhydrases from molluscs, such as nacrein, which are part of the organic matrix layer in shells. Other members of this family may be involved in maintaining pH balance, in facilitating transport of carbon dioxide or carbonic acid, or in sensing carbon dioxide levels in the environment. Dioscorin is the major storage protein of yam tubers and may play a role as an antioxidant. Tobacco Nectarin may play a role in the maintenace of pH and oxidative balance in nectar. Mollusc nacrein may participate in calcium carbonate crystal formation of the nacreous layer. This subfamily also includes three alpha carbonic anhydrases from Chlamydomonas reinhardtii (CAH 1-3). CAHs1-2 are localized in the periplasmic space. CAH1 faciliates the movement of carbon dioxide across the plasma membrane when the medium is alkaline. CAH3 is localized to the thylakoid lumen and provides CO2 to Rubisco.


Pssm-ID: 239398 [Multi-domain]  Cd Length: 216  Bit Score: 145.49  E-value: 1.60e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  39 GPHFWGLVEKDWWMCKKGRLQSPIDIQPDRLLFDaSVKPVRLDKLPVVSEFVNTGQMVRVRIGYSSKKPSVNITSgplyg 118
Cdd:cd03124     1 GPEHWGNLDPEFALCATGKNQSPIDITTKAVVSD-KLPPLNYNYKPTSATLVNNGHTIQVNFEGNGGTLTIDGET----- 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 119 yrYRVQRIDFHMGrknengSEHTINGRRFPMEVQLVayntdlypnFTSASKsphGIAILSVLVDFGPEtNQELIKltIAT 198
Cdd:cd03124    75 --YQLLQFHFHSP------SEHLINGKRYPLEAHLV---------HKSKDG---QLAVVAVLFEEGKE-NPFLKK--ILD 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 199 ASISYKDQRVQLADFE-PWRLLPFTRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLYLSMegaekvpvap 277
Cdd:cd03124   132 NMPKKEGTEVNLPAILdPNELLPESRSYYRYEGSLTTPPCSEGVRWIVLKQPITISKEQLAKFRAAVYPN---------- 201
                         250
                  ....*....|...
gi 1017384731 278 NFRKIQETNNRLV 290
Cdd:cd03124   202 NARPVQPLNGREV 214
Cah COG3338
Carbonic anhydrase [Inorganic ion transport and metabolism];
8-290 2.47e-41

Carbonic anhydrase [Inorganic ion transport and metabolism];


Pssm-ID: 442567 [Multi-domain]  Cd Length: 247  Bit Score: 143.49  E-value: 2.47e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731   8 FPLFLIILTCHISPLKSSQNYQWSYDSDvfGGPHFWGLVEKDWWMCKKGRLQSPIDIQPDRllfDASVKPVRLDKLPVVS 87
Cdd:COG3338     6 LLALLLAAALPAAAAAAASAPHWSYEGE--TGPEHWGELSPEFATCATGKNQSPIDIRTAI---KADLPPLKFDYKPTPL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  88 EFVNTGQMVRVRIGYSSkkpsvNITSGplyGYRYRVQRIDFHMGrknengSEHTINGRRFPMEVQLVayntdlypnftsa 167
Cdd:COG3338    81 EIVNNGHTIQVNVDPGS-----TLTVD---GKRYELKQFHFHTP------SEHTINGKSYPMEAHLV------------- 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 168 SKSPHG-IAILSVLVDFGPEtNQELIKLtIATASISYKDQRVQLADFEPWRLLPFTRDIITYEGSLTSPGCHETVTWIIL 246
Cdd:COG3338   134 HKDADGeLAVVGVLFEEGAE-NPALAKL-WANLPLEAGEEVALDATIDLNDLLPEDRSYYRYSGSLTTPPCSEGVLWIVL 211
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1017384731 247 NQPIFIKKEHFEEWSHLYlsmegaekvpvAPNFRKIQETNNRLV 290
Cdd:COG3338   212 KQPITVSAEQIEAFARLY-----------PNNARPVQPLNGRLI 244
alpha_CA_IX cd03150
Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
56-293 3.91e-38

Carbonic anhydrase alpha, isozyme IX. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Alpha CAs are strictly monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the membrane protein CA IX. CA IX is functionally implicated in tumor growth and survival. CA IX is mainly present in solid tumors and its expression in normal tissues is limited to the mucosa of alimentary tract. CA IX is a transmembrane protein with two extracellular domains: carbonic anhydrase and, a proteoglycan-like segment mediating cell-cell adhesion. There is evidence for an involvement of the MAPK pathway in the regulation of CA9 expression.


Pssm-ID: 239403  Cd Length: 247  Bit Score: 135.08  E-value: 3.91e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  56 GRLQSPIDIQPDRLLFDASVKPVRLD--KLPVVSEF--VNTGQMVRVrigysSKKPSVNITSGPlyGYRYRVQRIDFHMG 131
Cdd:cd03150    14 GRFQSPVDIRPHLVAFCPALRPLELLgfDLPPSPSLrlLNNGHTVQL-----SLPSGLRMALGP--GQEYRALQLHLHWG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 132 RKNENGSEHTINGRRFPMEVQLVAYNTDlYPNFTSASKSPHGIAILSVLVDFGPETNQELIKLTIATASISYKDQRVQLA 211
Cdd:cd03150    87 AAGRPGSEHTVDGHRFPAEIHVVHLSTA-FANLDEALGRPGGLAVLAAFLAEGLHENSAYEQLLSRLSEISEEESETVVP 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 212 DFEPWRLLP--FTRdIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHlylSMEGAEKVPVAPNFRKIQETNNRL 289
Cdd:cd03150   166 GLDVSALLPsdLSR-YFRYEGSLTTPPCAQGVIWTVFNQTVRLSAKQLHTLSD---SLWGPHDSRLQLNFRATQPLNGRK 241

                  ....
gi 1017384731 290 VRTN 293
Cdd:cd03150   242 IEAS 245
alpha_CA_VI cd03125
Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes ...
56-295 8.88e-28

Carbonic anhydrase alpha, isozyme VI. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed by the regeneration of the active site by ionization of the zinc-bound water molecule and removal of a proton from the active site. They are ubiquitous enzymes involved in fundamental processes like photosynthesis, respiration, pH homeostasis and ion transport. There are three evolutionary distinct groups - alpha, beta and gamma carbonic anhydrases - which show no significant sequence identity or structural similarity. Most alpha CAs are monomeric enzymes. The zinc ion is complexed by three histidine residues. This sub-family comprises the secreted CA VI, which is found in saliva.


Pssm-ID: 239399  Cd Length: 249  Bit Score: 107.95  E-value: 8.88e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  56 GRLQSPIDIQPDRLLFDASVKPVRL---DKLPVVSEFVNTGQMVRVRIgysskKPSVNITSGplYGYRYRVQRIDFHMG- 131
Cdd:cd03125    14 GKRQSPIDIQRREVRFNPSLLQLELvgyEKEQGEFTMTNNGHTVQIDL-----PPTMSITTG--DGTVYTAVQMHFHWGg 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 132 RKNE-NGSEHTINGRRFPMEVQLVAYNTDlYPNFTSASKSPHGIAILSVLVDFGPETNQELIKLTIAT-ASISYKDQRVQ 209
Cdd:cd03125    87 RDSEiSGSEHTIDGMRYVAELHIVHYNSK-YKSYEEAKDKPDGLAVLAFLYKVGHYAENTYYSDFISKlAKIKYAGQTTT 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 210 LADFEPWRLLPftRDII---TYEGSLTSPGCHETVTWIILNQPIFIKKEHFEEWSHLYLSMEGAEkvpVAPNFRKIQETN 286
Cdd:cd03125   166 LTSLDVRDMLP--ENLHhyyTYQGSLTTPPCTENVLWFVFDDPVTLSKTQIVKLENTLMDHHNKT---IRNDYRRTQPLN 240

                  ....*....
gi 1017384731 287 NRLVRTNIQ 295
Cdd:cd03125   241 HRVVEANFL 249
PLN02179 PLN02179
carbonic anhydrase
30-245 1.01e-13

carbonic anhydrase


Pssm-ID: 177835  Cd Length: 235  Bit Score: 69.24  E-value: 1.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  30 WSYDSDVFGGPHFWGLVEKDWWMCKKGRLQSPIDIQPDR--LLFDASVKpvrLDKLPVVSEFVNTGQMVRVRIGYSSKKP 107
Cdd:PLN02179   37 FTYKQKTEKGPAEWGKLNPQWKVCSTGKYQSPIDLTDERvsLIHDQALS---RHYKPAPAVIQSRGHDVMVSWKGDAGKI 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 108 SVNITSgplygyrYRVQRIDFHmgrkneNGSEHTINGRRFPMEVQLVayntdlypnFTSASKSphgIAILSVLVDFGpET 187
Cdd:PLN02179  114 TIHQTD-------YKLVQCHWH------SPSEHTINGTSYDLELHMV---------HTSASGK---TAVVGVLYKLG-EP 167
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1017384731 188 NQELIKLTIATASISYKDqrVQLADFEPWRLLPFTRDIITYEGSLTSPGCHETVTWII 245
Cdd:PLN02179  168 DEFLTKLLNGIKGVGKKE--INLGIVDPRDIRFETNNFYRYIGSLTIPPCTEGVIWTV 223
PLN02202 PLN02202
carbonate dehydratase
36-258 4.36e-09

carbonate dehydratase


Pssm-ID: 177853 [Multi-domain]  Cd Length: 284  Bit Score: 56.22  E-value: 4.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731  36 VFG-----GPHFWGLVEKDWWMCKKGRLQSPIDIQPDRLLFDASVKPVRLDKLPVVSEFVNtgQMVRVRIGYSSKKPSVN 110
Cdd:PLN02202   30 VFGykgknGPNQWGHLNPHFTKCAVGKLQSPIDIQRRQIFYNHKLESIHRDYYFTNATLVN--HVCNVAMFFGEGAGDVI 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017384731 111 ITSGplygyRYRVQRIDFHmgrkneNGSEHTINGRRFPMEVQLVAYNTDlypnftsaskspHGIAILSVLVDFGPE---- 186
Cdd:PLN02202  108 IDNK-----NYTLLQMHWH------TPSEHHLHGVQYAAELHMVHQAKD------------GSFAVVASLFKIGTEepfl 164
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1017384731 187 --TNQELIKLTIATASISYKDQrVQLADFEPWRLLPFTRDIITYEGSLTSPGCHETVTWIILNQPIFIKKEHFE 258
Cdd:PLN02202  165 sqMKDKLVKLKEERFKGNHTAQ-VEVGKIDTRHIERKTRKYFRYIGSLTTPPCSENVSWTILGKVRSMSKEQVE 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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