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Conserved domains on  [gi|1017461086|ref|NP_001309466|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 26-329 7.94e-79

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 243.90  E-value: 7.94e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086  26 IERGFTCFGMFCNLVLLPLIMFKSPTDMGVYKFLMVYIAVFELFFGWLELMTVTNLYTQGSLFTVVVDPDEAFLPDGLLQ 105
Cdd:pfam10326   4 IQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086 106 ISCLIYCGSFATSLAMFGVQFAYRYQVLKGNSIWTSRSSFTFFFWGSIPLLVALMWTLSCSIYLGRNDYVVYAISQ---Q 182
Cdd:pfam10326  84 ILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREellE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086 183 SYPISLENktVGFVAVYFYPGLADGSTTINWDSFIGMSLCTCILFGSESLMLYFALKSYLVTKSLMTSAySANFQKLQWQ 262
Cdd:pfam10326 164 NYNLDIDE--VAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1017461086 263 LFYALVSQAVIPIFFMQIPLSAIYITLFANISTPFFGHLQELTISFYLATDALPTIFIIKPYREFIF 329
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 26-329 7.94e-79

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 243.90  E-value: 7.94e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086  26 IERGFTCFGMFCNLVLLPLIMFKSPTDMGVYKFLMVYIAVFELFFGWLELMTVTNLYTQGSLFTVVVDPDEAFLPDGLLQ 105
Cdd:pfam10326   4 IQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086 106 ISCLIYCGSFATSLAMFGVQFAYRYQVLKGNSIWTSRSSFTFFFWGSIPLLVALMWTLSCSIYLGRNDYVVYAISQ---Q 182
Cdd:pfam10326  84 ILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREellE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086 183 SYPISLENktVGFVAVYFYPGLADGSTTINWDSFIGMSLCTCILFGSESLMLYFALKSYLVTKSLMTSAySANFQKLQWQ 262
Cdd:pfam10326 164 NYNLDIDE--VAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1017461086 263 LFYALVSQAVIPIFFMQIPLSAIYITLFANISTPFFGHLQELTISFYLATDALPTIFIIKPYREFIF 329
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 26-329 7.94e-79

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 243.90  E-value: 7.94e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086  26 IERGFTCFGMFCNLVLLPLIMFKSPTDMGVYKFLMVYIAVFELFFGWLELMTVTNLYTQGSLFTVVVDPDEAFLPDGLLQ 105
Cdd:pfam10326   4 IQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVGQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086 106 ISCLIYCGSFATSLAMFGVQFAYRYQVLKGNSIWTSRSSFTFFFWGSIPLLVALMWTLSCSIYLGRNDYVVYAISQ---Q 182
Cdd:pfam10326  84 ILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREellE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086 183 SYPISLENktVGFVAVYFYPGLADGSTTINWDSFIGMSLCTCILFGSESLMLYFALKSYLVTKSLMTSAySANFQKLQWQ 262
Cdd:pfam10326 164 NYNLDIDE--VAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1017461086 263 LFYALVSQAVIPIFFMQIPLSAIYITLFANISTPFFGHLQELTISFYLATDALPTIFIIKPYREFIF 329
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 22-281 4.12e-17

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 80.75  E-value: 4.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086  22 TFQGIERGFTCFGMFCNLVLLPLIMFKSPTDMGVYKFLMVYIAVFELFFGWLELMTVTNLYTQGSLFTVVVDPDEAFLPD 101
Cdd:pfam10319   6 AHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086 102 GLLQISCLIYCGSFATSLAMFGVQFAYRYQVLKgNSIWTSRSSFTFFFWGSIPLLVALM--WTLSCSIYLGRN----DYV 175
Cdd:pfam10319  86 ELGQHALSARCSFISASYAVLLIHFIYRYLVLF-NPQLTRHYFRPWGILISILFFLFHGsvWTAICYFLLRANdeirDYI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086 176 VYAISQQsypISLENKTVGFVAVYFYpglaDGSTTINWDSFIGMSLCTCIlfGSESLMLYFALkSYLVTKSL--MTSAYS 253
Cdd:pfam10319 165 REDFRET---YGVDSMDINMLGALYW----EASDETVFRSWLGILLLTVI--SVYSIILYIVL-GYKIMRKLnkMSVTMS 234

                         250       260
                  ....*....|....*....|....*...
gi 1017461086 254 ANFQKLQWQLFYALVSQAVIPIFFMQIP 281
Cdd:pfam10319 235 KKTKRLQKQLLKALIVQTIIPICISFSP 262
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 30-328 5.14e-11

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 62.57  E-value: 5.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086  30 FTCFGMFCNLVLLPLIMFKSPTDMGVYKFLMVYIAVFELFfgwlelMTVTNLYTQ----GSLFTVvvdpdeAFLPDGLLQ 105
Cdd:pfam10317   8 FFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQII------SCILAFFTQqriiPNGVSM------ALISYGPCK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086 106 ----ISCL----IYCGSFATSLAMFGVQFAYRYQVLKGNSIwTSRSSFTFFFWGSIPLLVALmwtlsCSIYLGRND-YVV 176
Cdd:pfam10317  76 yfgpWFCYsgysLLQHFLLHSGWSLLLTFYYRYYILKHVDP-KRKKLILLIIIHYIPSLSQL-----IVIFLSPTDfLPV 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086 177 YAISQQSYP-ISLENKTV-GFvavyfypgladgSTTINWDSFIGMSLCTCILFGSESLMLYFALKSYLVTKSlMTSAYSA 254
Cdd:pfam10317 150 EALTKELHPnYNLTDYTVtGF------------SDLQSFPALINTLIMTIPVFPIPIIILILRRKILKLLNS-NSVNMSP 216

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1017461086 255 NFQKLQWQLFYALVSQAVIPIFFMqIPLSAIY-ITLFANISTPFFGHLQELTISFYLATDALPTIFIIKPYREFI 328
Cdd:pfam10317 217 TTKAQHRQLIKGLTIQALLPLFSY-IPGVTLYlLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAI 290
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 22-334 2.09e-08

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 54.86  E-value: 2.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086  22 TFQGIERGFTCFGMFCnlvllplIMFKSPTDMGVYKFLMVY----IAVFELFFGWLelMTVTNLYtqgslftvvvdPDEA 97
Cdd:pfam10318  12 IITVISIPIHIFGFYC-------ILFKTPKKMKSVKWSLLNlhfwSALLDLSLSFL--TIPYIFL-----------PALA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086  98 FLPDGLLQ-----ISCLIYCGsfATSLAMFGV----QFAYRYQVLKGNSIWTSRSSFTFFFwgsIPLLVALMWTLSCSIY 168
Cdd:pfam10318  72 GYPLGLLSylgvpTPIQFYIG--VTSLALVGVsiilLFENRYSILFTNKKRITWKKTRVLY---LIFNYIIALLFLIPIY 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086 169 LGRNDyvvyaisQQSYPISLENKTVGFVAVYFYpglADGSTTINWDSFIGMSLCTCILFGSESLMLYFALKSYLVTKSLM 248
Cdd:pfam10318 147 LNIPD-------QEAAKLKVLKKLPCLPPEFFD---NPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSV 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461086 249 TSAYSANFQKLQWQLFYALVSQAVIPIFFMQIPLSAIYITLFANISTPFFGHLQELTISFYLATDALPTIFIIKPYREFI 328
Cdd:pfam10318 217 KSSLSKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFV 296


                  ....*.
gi 1017461086 329 FSTLRC 334
Cdd:pfam10318 297 LSLFKK 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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