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Conserved domains on  [gi|1017461088|ref|NP_001309465|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 17-319 6.44e-103

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 304.76  E-value: 6.44e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461088  17 AQRVAQFGFFATTTSCTVLILLTIYGVKRDFGSYKNLLLMFAGLGIVFATTEVLLFPNLHSYNAGYFFYSMERPFRLDTK 96
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461088  97 NVSRFLVIYTGLYGSTICLLSVQFVYRYWAVFSESKLKFFKGWRFIFCIMYCAAFGADWGLSIYYFDEMDAYADHYFRAE 176
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461088 177 MHKRYRLNISEVACFSLVAYNFDNT----PRWRNILCTISLFCIMLIQYTIIIYCATIMYLKMEEKLKLLSVSIRNLHRQ 252
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENgskvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1017461088 253 FYKTLVIQIFTPTICLFSPLIFIIFHPLFNVEIVVPTGMLLCAITIYPAVDAIIIMYVVTDYRNAIK 319
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 17-319 6.44e-103

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 304.76  E-value: 6.44e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461088  17 AQRVAQFGFFATTTSCTVLILLTIYGVKRDFGSYKNLLLMFAGLGIVFATTEVLLFPNLHSYNAGYFFYSMERPFRLDTK 96
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461088  97 NVSRFLVIYTGLYGSTICLLSVQFVYRYWAVFSESKLKFFKGWRFIFCIMYCAAFGADWGLSIYYFDEMDAYADHYFRAE 176
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461088 177 MHKRYRLNISEVACFSLVAYNFDNT----PRWRNILCTISLFCIMLIQYTIIIYCATIMYLKMEEKLKLLSVSIRNLHRQ 252
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENgskvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1017461088 253 FYKTLVIQIFTPTICLFSPLIFIIFHPLFNVEIVVPTGMLLCAITIYPAVDAIIIMYVVTDYRNAIK 319
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 17-319 6.44e-103

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 304.76  E-value: 6.44e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461088  17 AQRVAQFGFFATTTSCTVLILLTIYGVKRDFGSYKNLLLMFAGLGIVFATTEVLLFPNLHSYNAGYFFYSMERPFRLDTK 96
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461088  97 NVSRFLVIYTGLYGSTICLLSVQFVYRYWAVFSESKLKFFKGWRFIFCIMYCAAFGADWGLSIYYFDEMDAYADHYFRAE 176
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461088 177 MHKRYRLNISEVACFSLVAYNFDNT----PRWRNILCTISLFCIMLIQYTIIIYCATIMYLKMEEKLKLLSVSIRNLHRQ 252
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYPTDENgskvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1017461088 253 FYKTLVIQIFTPTICLFSPLIFIIFHPLFNVEIVVPTGMLLCAITIYPAVDAIIIMYVVTDYRNAIK 319
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 44-318 1.29e-24

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 101.55  E-value: 1.29e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461088  44 KRDFGSYKNLLLMFAGLGIVFATTEVLLFPNLHSYNAGYFFYSMERPFRLDTKNVSRFLVIYTGLYGSTICLLSVQFVYR 123
Cdd:pfam10319  34 SSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYSELGQHALSARCSFISASYAVLLIHFIYR 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461088 124 YWAVFSESKL-KFFKGWRFIFCIMYCAAFGADWGLSIYYF----DEMDAYADHYFRaemhKRYRLNISEVACFSLVAYNF 198
Cdd:pfam10319 114 YLVLFNPQLTrHYFRPWGILISILFFLFHGSVWTAICYFLlranDEIRDYIREDFR----ETYGVDSMDINMLGALYWEA 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461088 199 DNTPRWRNILCTISLFCIMLIQYTIIIYCATIMYLKMEEKLKLLSVSIRNLHRQFYKTLVIQIFTPTICLFSPLIFIIFH 278
Cdd:pfam10319 190 SDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKALIVQTIIPICISFSPCVLAWYS 269

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1017461088 279 PLFNVEIvvptGMLL-----CAITIYPAVDAIIIMYVVTDYRNAI 318
Cdd:pfam10319 270 PIFGIDL----GRWNnylevIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 115-320 1.06e-08

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 55.63  E-value: 1.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461088 115 LLSVQFVYRYWAVFSESKLKffKGWRFIFCIMYCAAFGAdwgLSIYYFDEMDAYADHYFRAEMHKRYRLNISEVACFSlv 194
Cdd:pfam10317  99 SLLLTFYYRYYILKHVDPKR--KKLILLIIIHYIPSLSQ---LIVIFLSPTDFLPVEALTKELHPNYNLTDYTVTGFS-- 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461088 195 aynfdNTPRWRNILCTISLFCIMLIQYTIIIYCATIMYLKMEEKLKLLSVSIRNLHRQFYKTLVIQIFTPTICLFSPLIF 274
Cdd:pfam10317 172 -----DLQSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALLPLFSYIPGVTL 246

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1017461088 275 IIFHPLFNVEIVVPTGMLLCAITIYPAVDAIIIMYVVTDYRNAIKK 320
Cdd:pfam10317 247 YLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAILR 292
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 47-324 5.48e-08

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 53.70  E-value: 5.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461088  47 FGSYKNLLL------MFAGLGIVFATTEVLLFPNLHSYNAGYFFYsmerpFRLDTKNVSRFLVIYTGLYGSTICLLsvqF 120
Cdd:pfam10318  36 MKSVKWSLLnlhfwsALLDLSLSFLTIPYIFLPALAGYPLGLLSY-----LGVPTPIQFYIGVTSLALVGVSIILL---F 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461088 121 VYRYWAVFSESKLKFFKGWRFIF-CIMYCAAFGadWGLSIYYF--DEMDAyadhyfRAEMHKRY-RLNISEVACFSLVAY 196
Cdd:pfam10318 108 ENRYSILFTNKKRITWKKTRVLYlIFNYIIALL--FLIPIYLNipDQEAA------KLKVLKKLpCLPPEFFDNPPVFVL 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1017461088 197 NFDNTprwRNILCTISLFCIMLIQYTIIIYCaTIMYLKMEEKLKLlSVSIRNLHRQFYKTLVIQIFTPTICLFSPLIFII 276
Cdd:pfam10318 180 AIDST---YFLICIVLLILILIIQILFFVFL-TIYYLFKSVKSSL-SKKTRKLQKKFFIALIIQVSIPLIVILIPLIYIL 254

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1017461088 277 FHPLFNVEIVVPTGMLLCAITIYPAVDAIIIMYVVTDYRNAIKKNFKK 324
Cdd:pfam10318 255 FSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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