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Conserved domains on  [gi|1015809736|ref|NP_001309110|]
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contactin-associated protein-like 4 isoform 6 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 54-175 3.90e-32

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 122.46  E-value: 3.90e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736   54 HGPGFARLNRrdAGGWSPLVSNKYQWLQIDLGERMEVTAVATQG--GYGSSNWVTSYLLMFSDSGWNWKQYRQEDSIWGF 131
Cdd:cd00057     24 WEASRARLNS--DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKVF 101

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1015809736  132 SGNANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFG 175
Cdd:cd00057    102 TGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 820-938 6.64e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 115.21  E-value: 6.64e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  820 FKTTASSGVFLEN-LGIADFIRIELRSPTVVtFSFDVGNGPFEISVqSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKT 898
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLV-LRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1015809736  899 QPAPADGHvLLQLNSQLFVGG--------TATRQRGFLGCIRSLQLNG 938
Cdd:pfam02210   79 SLPPGESL-LLNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNG 125
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 211-340 5.61e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 112.90  E-value: 5.61e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  211 FKTMQSDGILLHREGPNGDHITLQLRRARLFLLINSGeaklpsTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEH 290
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLG------SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809736  291 RHHFHARGEFNL-MNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 340
Cdd:pfam02210   75 TVVSSLPPGESLlLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 397-523 8.95e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 97.88  E-value: 8.95e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  397 FRTWNKAGLLLFSElQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMA-SA 475
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVvSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1015809736  476 APLLGPEQIYSGGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISISGK 523
Cdd:pfam02210   80 LPPGESLLLNLNGPLYLGGLPPLL-LLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1045-1175 1.17e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 80.54  E-value: 1.17e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736 1045 FRTTRTPSLLLFVSSFYKEYLSVIIaKNGSLQIRYKLNKYQEPDVVNFdfKNMADGQLHHIMINREEGVVFIEIDDNRRR 1124
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSG--KNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809736 1125 QVHLSSGTE-FSAVKSLVLGRileHSDVDQDTALAGAQGFTGCLSAVQLSHV 1175
Cdd:pfam02210   78 SSLPPGESLlLNLNGPLYLGG---LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
GGGWT_bact super family cl49103
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 592-633 4.15e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


The actual alignment was detected with superfamily member NF040941:

Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 50.64  E-value: 4.15e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1015809736  592 SCEAYKHRGNT--SGFYYIDSDGSGPLEPFLLYCNMTET--AWTII 633
Cdd:NF040941     1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCDMTTDggGWTLV 46
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 552-583 7.65e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 7.65e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1015809736  552 CLPNYCEHGGECSQSWSTFHCNCTnTGYRGAT 583
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
COLFI super family cl02436
Fibrillar collagen C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia ...
 603-686 4.90e-04

Fibrillar collagen C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.


The actual alignment was detected with superfamily member smart00038:

Pssm-ID: 470578  Cd Length: 232  Bit Score: 43.23  E-value: 4.90e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736   603 SGFYYIDSDGSGPLEPFLLYCNMtETAWTIIQHNGSDLTRVRNTNPENPYAGF---------FEYVAS----MEQLQATI 669
Cdd:smart00038   44 SGEYWVDPNQGCIRDAIKVFCNF-ETGETCVSPSPSSIPRKTWYSGKSKHVWFgetmnggfkFSYGDSegppVGVVQLTF 122

                            90
                    ....*....|....*....
gi 1015809736   670 NR--AEHCEQEFTYYCKKS 686
Cdd:smart00038  123 LRllSTEAHQNITYHCKNS 141
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 961-995 1.48e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.48e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1015809736  961 CSSYGkLCRNGGKCRERPIGFFCDCTfSAYTGPFC 995
Cdd:cd00054      5 CASGN-PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 54-175 3.90e-32

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 122.46  E-value: 3.90e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736   54 HGPGFARLNRrdAGGWSPLVSNKYQWLQIDLGERMEVTAVATQG--GYGSSNWVTSYLLMFSDSGWNWKQYRQEDSIWGF 131
Cdd:cd00057     24 WEASRARLNS--DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKVF 101

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1015809736  132 SGNANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFG 175
Cdd:cd00057    102 TGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 54-173 5.92e-30

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 115.62  E-value: 5.92e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736   54 HGPGFARLNRRDAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGY-GSSNWVTSYLLMFSDSGWNWKQYRQEdsiwGFS 132
Cdd:pfam00754   11 EGPAAAALDGDPNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQdGSNGYVTSYKIEYSLDGENWTTVKDE----KIP 86

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1015809736  133 GNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEV 173
Cdd:pfam00754   87 GNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 820-938 6.64e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 115.21  E-value: 6.64e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  820 FKTTASSGVFLEN-LGIADFIRIELRSPTVVtFSFDVGNGPFEISVqSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKT 898
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLV-LRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1015809736  899 QPAPADGHvLLQLNSQLFVGG--------TATRQRGFLGCIRSLQLNG 938
Cdd:pfam02210   79 SLPPGESL-LLNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 793-937 7.66e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 115.98  E-value: 7.66e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  793 SASFDTEaSYLHFPTFHGEL-SADVSFFFKTTASSGV--FLENLGIADFIRIELRSPTVVtfsFDVGNGPFEISVQSPTH 869
Cdd:cd00110      1 GVSFSGS-SYVRLPTLPAPRtRLSISFSFRTTSPNGLllYAGSQNGGDFLALELEDGRLV---LRYDLGSGSLVLSSKTP 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1015809736  870 FNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPaDGHVLLQLNSQLFVGGT--------ATRQRGFLGCIRSLQLN 937
Cdd:cd00110     77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSP-GGSALLNLDGPLYLGGLpedlkspgLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 211-340 5.61e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 112.90  E-value: 5.61e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  211 FKTMQSDGILLHREGPNGDHITLQLRRARLFLLINSGeaklpsTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEH 290
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLG------SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809736  291 RHHFHARGEFNL-MNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 340
Cdd:pfam02210   75 TVVSSLPPGESLlLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
815-939 1.73e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 111.66  E-value: 1.73e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736   815 DVSFFFKTTASSGV--FLENLGIADFIRIELRSPTVVtFSFDVGNGPFEISVQsPTHFNDNQWHHVRVERNMKEASLQVD 892
Cdd:smart00282    1 SISFSFRTTSPNGLllYAGSKGGGDYLALELRDGRLV-LRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1015809736   893 QLTPKTQPAPAdGHVLLQLNSQLFVGGT--------ATRQRGFLGCIRSLQLNGM 939
Cdd:smart00282   79 GGNRVSGESPG-GLTILNLDGPLYLGGLpedlklppLPVTPGFRGCIRNLKVNGK 132
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 55-176 1.19e-26

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 106.44  E-value: 1.19e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736    55 GPGFARLNRRDAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSNWVTSYlLMFSDSGWNWKQYRQEDSIwGFSGN 134
Cdd:smart00231   22 AAKIARLNGGSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYK-LEYSDDGVNWTTYKDGNSK-VFPGN 99

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|..
gi 1015809736   135 ANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFGC 176
Cdd:smart00231  100 SDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 397-523 8.95e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 97.88  E-value: 8.95e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  397 FRTWNKAGLLLFSElQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMA-SA 475
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVvSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1015809736  476 APLLGPEQIYSGGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISISGK 523
Cdd:pfam02210   80 LPPGESLLLNLNGPLYLGGLPPLL-LLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 193-338 3.23e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.10  E-value: 3.23e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  193 YRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQLRRARLFLLINSGEAKLPststlvnLTLGSLLDDQHW 271
Cdd:cd00110     10 VRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSqNGGDFLALELEDGRLVLRYDLGSGSLV-------LSSKTPLNDGQW 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1015809736  272 HSVLIQRLGKQVNFTVDEHRH-HFHARGEFNLMNLDYEISFGGIPAPGKSVSFPHRN-FHGCLENLYYN 338
Cdd:cd00110     83 HSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPgFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 370-520 1.09e-22

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 95.56  E-value: 1.09e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  370 PVTFlSSRSYLALPDFSGEE-EVSATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNlYQPGKLPSDITAGVELN 448
Cdd:cd00110      1 GVSF-SGSSYVRLPTLPAPRtRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLR-YDLGSGSLVLSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1015809736  449 DGQWHSVSLSAKKNHLSVAVDG-QMASAAPLLGPEQIYSGGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISI 520
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGeRVVESGSPGGSALLNLDGPLYLGGLPEDL-KSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
207-340 1.99e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 94.33  E-value: 1.99e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736   207 ISLKFKTMQSDGILLHREGPNG-DHITLQLRRARLFLLIN--SGEAKLPSTSTLVNltlgslldDQHWHSVLIQRLGKQV 283
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDlgSGPARLTSDPTPLN--------DGQWHRVAVERNGRSV 73

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1015809736   284 NFTVDEHRH-HFHARGEFNLMNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 340
Cdd:smart00282   74 TLSVDGGNRvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPvTPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
392-523 3.42e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 87.78  E-value: 3.42e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736   392 SATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQ 471
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1015809736   472 MASAAPLLGPEQIY-SGGTYYFGGCPDkSFGSKCKSPLGGFQGCMRLISISGK 523
Cdd:smart00282   81 NRVSGESPGGLTILnLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1045-1175 1.17e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 80.54  E-value: 1.17e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736 1045 FRTTRTPSLLLFVSSFYKEYLSVIIaKNGSLQIRYKLNKYQEPDVVNFdfKNMADGQLHHIMINREEGVVFIEIDDNRRR 1124
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSG--KNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809736 1125 QVHLSSGTE-FSAVKSLVLGRileHSDVDQDTALAGAQGFTGCLSAVQLSHV 1175
Cdd:pfam02210   78 SSLPPGESLlLNLNGPLYLGG---LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1041-1172 5.45e-13

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 67.83  E-value: 5.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736 1041 IKFSFRTTRTPSLLLFVSSF-YKEYLSVIIaKNGSLQIRYKLNKyqEPDVVNFDfKNMADGQLHHIMINREEGVVFIEID 1119
Cdd:cd00110     24 ISFSFRTTSPNGLLLYAGSQnGGDFLALEL-EDGRLVLRYDLGS--GSLVLSSK-TPLNDGQWHSVSVERNGRSVTLSVD 99

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1015809736 1120 DNRRRQVHLSSGTEF-SAVKSLVLGRILEHSDVdqdTALAGAQGFTGCLSAVQL 1172
Cdd:cd00110    100 GERVVESGSPGGSALlNLDGPLYLGGLPEDLKS---PGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
1041-1175 1.31e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 66.21  E-value: 1.31e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  1041 IKFSFRTTRTPSLLLFVSSFYK-EYLSVIIaKNGSLQIRYKLNkyQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEID 1119
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLG--SGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1015809736  1120 DNRRRQVHLSSGTEFSAVKS-LVLGRILEHSDVDQDTAlagAQGFTGCLSAVQLSHV 1175
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGpLYLGGLPEDLKLPPLPV---TPGFRGCIRNLKVNGK 132
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 592-633 4.15e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 50.64  E-value: 4.15e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1015809736  592 SCEAYKHRGNT--SGFYYIDSDGSGPLEPFLLYCNMTET--AWTII 633
Cdd:NF040941     1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCDMTTDggGWTLV 46
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 552-583 7.65e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 7.65e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1015809736  552 CLPNYCEHGGECSQSWSTFHCNCTnTGYRGAT 583
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 591-638 2.78e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 43.77  E-value: 2.78e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1015809736  591 QSC-EAYKHRGNTSGFYYIDSDGSgpLEPFLLYCNMTET--AWTIIQH--NGS 638
Cdd:cd00087      4 RDCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDTDggGWTVIQRrgDGS 54
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 594-642 4.36e-04

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 43.03  E-value: 4.36e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1015809736   594 EAYKHRGNTSGFYYIDSDGSGplEPFLLYCNMTETA--WTIIQH--NGS-DLTR 642
Cdd:smart00186    7 DVLQNGGKTSGLYTIYPDGSS--RPLKVYCDMETDGggWTVIQRrmDGSvDFYR 58
COLFI smart00038
Fibrillar collagens C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia ...
 603-686 4.90e-04

Fibrillar collagens C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.


Pssm-ID: 197483  Cd Length: 232  Bit Score: 43.23  E-value: 4.90e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736   603 SGFYYIDSDGSGPLEPFLLYCNMtETAWTIIQHNGSDLTRVRNTNPENPYAGF---------FEYVAS----MEQLQATI 669
Cdd:smart00038   44 SGEYWVDPNQGCIRDAIKVFCNF-ETGETCVSPSPSSIPRKTWYSGKSKHVWFgetmnggfkFSYGDSegppVGVVQLTF 122

                            90
                    ....*....|....*....
gi 1015809736   670 NR--AEHCEQEFTYYCKKS 686
Cdd:smart00038  123 LRllSTEAHQNITYHCKNS 141
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 961-995 1.48e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.48e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1015809736  961 CSSYGkLCRNGGKCRERPIGFFCDCTfSAYTGPFC 995
Cdd:cd00054      5 CASGN-PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 550-584 1.94e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.94e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1015809736  550 DRCL-PNYCEHGGECSQSWSTFHCNCTNtGYRGATC 584
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 54-175 3.90e-32

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 122.46  E-value: 3.90e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736   54 HGPGFARLNRrdAGGWSPLVSNKYQWLQIDLGERMEVTAVATQG--GYGSSNWVTSYLLMFSDSGWNWKQYRQEDSIWGF 131
Cdd:cd00057     24 WEASRARLNS--DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKVF 101

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1015809736  132 SGNANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFG 175
Cdd:cd00057    102 TGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 54-173 5.92e-30

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 115.62  E-value: 5.92e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736   54 HGPGFARLNRRDAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGY-GSSNWVTSYLLMFSDSGWNWKQYRQEdsiwGFS 132
Cdd:pfam00754   11 EGPAAAALDGDPNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQdGSNGYVTSYKIEYSLDGENWTTVKDE----KIP 86

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1015809736  133 GNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEV 173
Cdd:pfam00754   87 GNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 820-938 6.64e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 115.21  E-value: 6.64e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  820 FKTTASSGVFLEN-LGIADFIRIELRSPTVVtFSFDVGNGPFEISVqSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKT 898
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLV-LRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1015809736  899 QPAPADGHvLLQLNSQLFVGG--------TATRQRGFLGCIRSLQLNG 938
Cdd:pfam02210   79 SLPPGESL-LLNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 793-937 7.66e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 115.98  E-value: 7.66e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  793 SASFDTEaSYLHFPTFHGEL-SADVSFFFKTTASSGV--FLENLGIADFIRIELRSPTVVtfsFDVGNGPFEISVQSPTH 869
Cdd:cd00110      1 GVSFSGS-SYVRLPTLPAPRtRLSISFSFRTTSPNGLllYAGSQNGGDFLALELEDGRLV---LRYDLGSGSLVLSSKTP 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1015809736  870 FNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPaDGHVLLQLNSQLFVGGT--------ATRQRGFLGCIRSLQLN 937
Cdd:cd00110     77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSP-GGSALLNLDGPLYLGGLpedlkspgLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 211-340 5.61e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 112.90  E-value: 5.61e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  211 FKTMQSDGILLHREGPNGDHITLQLRRARLFLLINSGeaklpsTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEH 290
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLG------SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809736  291 RHHFHARGEFNL-MNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 340
Cdd:pfam02210   75 TVVSSLPPGESLlLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
815-939 1.73e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 111.66  E-value: 1.73e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736   815 DVSFFFKTTASSGV--FLENLGIADFIRIELRSPTVVtFSFDVGNGPFEISVQsPTHFNDNQWHHVRVERNMKEASLQVD 892
Cdd:smart00282    1 SISFSFRTTSPNGLllYAGSKGGGDYLALELRDGRLV-LRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1015809736   893 QLTPKTQPAPAdGHVLLQLNSQLFVGGT--------ATRQRGFLGCIRSLQLNGM 939
Cdd:smart00282   79 GGNRVSGESPG-GLTILNLDGPLYLGGLpedlklppLPVTPGFRGCIRNLKVNGK 132
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 55-176 1.19e-26

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 106.44  E-value: 1.19e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736    55 GPGFARLNRRDAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSNWVTSYlLMFSDSGWNWKQYRQEDSIwGFSGN 134
Cdd:smart00231   22 AAKIARLNGGSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYK-LEYSDDGVNWTTYKDGNSK-VFPGN 99

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|..
gi 1015809736   135 ANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFGC 176
Cdd:smart00231  100 SDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 397-523 8.95e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 97.88  E-value: 8.95e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  397 FRTWNKAGLLLFSElQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMA-SA 475
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVvSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1015809736  476 APLLGPEQIYSGGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISISGK 523
Cdd:pfam02210   80 LPPGESLLLNLNGPLYLGGLPPLL-LLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 193-338 3.23e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.10  E-value: 3.23e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  193 YRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQLRRARLFLLINSGEAKLPststlvnLTLGSLLDDQHW 271
Cdd:cd00110     10 VRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSqNGGDFLALELEDGRLVLRYDLGSGSLV-------LSSKTPLNDGQW 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1015809736  272 HSVLIQRLGKQVNFTVDEHRH-HFHARGEFNLMNLDYEISFGGIPAPGKSVSFPHRN-FHGCLENLYYN 338
Cdd:cd00110     83 HSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPgFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 370-520 1.09e-22

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 95.56  E-value: 1.09e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  370 PVTFlSSRSYLALPDFSGEE-EVSATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNlYQPGKLPSDITAGVELN 448
Cdd:cd00110      1 GVSF-SGSSYVRLPTLPAPRtRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLR-YDLGSGSLVLSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1015809736  449 DGQWHSVSLSAKKNHLSVAVDG-QMASAAPLLGPEQIYSGGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISI 520
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGeRVVESGSPGGSALLNLDGPLYLGGLPEDL-KSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
207-340 1.99e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 94.33  E-value: 1.99e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736   207 ISLKFKTMQSDGILLHREGPNG-DHITLQLRRARLFLLIN--SGEAKLPSTSTLVNltlgslldDQHWHSVLIQRLGKQV 283
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDlgSGPARLTSDPTPLN--------DGQWHRVAVERNGRSV 73

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1015809736   284 NFTVDEHRH-HFHARGEFNLMNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 340
Cdd:smart00282   74 TLSVDGGNRvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPvTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
820-942 1.05e-20

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 89.30  E-value: 1.05e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  820 FKTTASSGVFLENLGIA--DFIRIELRSPTVvTFSFDVGNGPfeISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPK 897
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTerDFLALELRDGRL-EVSYDLGSGA--AVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARP 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1015809736  898 T--QPAPADGHvlLQLNSQLFVGGT---------ATRQRGFLGCIRSLQLNGMTLD 942
Cdd:pfam00054   78 TgeSPLGATTD--LDVDGPLYVGGLpslgvkkrrLAISPSFDGCIRDVIVNGKPLD 131
LamG smart00282
Laminin G domain;
392-523 3.42e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 87.78  E-value: 3.42e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736   392 SATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQ 471
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1015809736   472 MASAAPLLGPEQIY-SGGTYYFGGCPDkSFGSKCKSPLGGFQGCMRLISISGK 523
Cdd:smart00282   81 NRVSGESPGGLTILnLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
397-526 1.13e-17

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 80.44  E-value: 1.13e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  397 FRTWNKAGLLLFSELQLISGGILLFLSDGKLKSnLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDG-QMASA 475
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEV-SYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGeARPTG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809736  476 APLLGPEQIYS-GGTYYFGGCPDKSFGSKCKSPLGGFQGCMRLISISGKVVD 526
Cdd:pfam00054   80 ESPLGATTDLDvDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1045-1175 1.17e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 80.54  E-value: 1.17e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736 1045 FRTTRTPSLLLFVSSFYKEYLSVIIaKNGSLQIRYKLNKYQEPDVVNFdfKNMADGQLHHIMINREEGVVFIEIDDNRRR 1124
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSG--KNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809736 1125 QVHLSSGTE-FSAVKSLVLGRileHSDVDQDTALAGAQGFTGCLSAVQLSHV 1175
Cdd:pfam02210   78 SSLPPGESLlLNLNGPLYLGG---LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1041-1172 5.45e-13

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 67.83  E-value: 5.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736 1041 IKFSFRTTRTPSLLLFVSSF-YKEYLSVIIaKNGSLQIRYKLNKyqEPDVVNFDfKNMADGQLHHIMINREEGVVFIEID 1119
Cdd:cd00110     24 ISFSFRTTSPNGLLLYAGSQnGGDFLALEL-EDGRLVLRYDLGS--GSLVLSSK-TPLNDGQWHSVSVERNGRSVTLSVD 99

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1015809736 1120 DNRRRQVHLSSGTEF-SAVKSLVLGRILEHSDVdqdTALAGAQGFTGCLSAVQL 1172
Cdd:cd00110    100 GERVVESGSPGGSALlNLDGPLYLGGLPEDLKS---PGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
1041-1175 1.31e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 66.21  E-value: 1.31e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  1041 IKFSFRTTRTPSLLLFVSSFYK-EYLSVIIaKNGSLQIRYKLNkyQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEID 1119
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLG--SGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1015809736  1120 DNRRRQVHLSSGTEFSAVKS-LVLGRILEHSDVDQDTAlagAQGFTGCLSAVQLSHV 1175
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGpLYLGGLPEDLKLPPLPV---TPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
211-340 1.97e-10

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 60.02  E-value: 1.97e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  211 FKTMQSDGILLHREGPN-GDHITLQLRRARLFLLINSGeaklpstSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVD- 288
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTeRDFLALELRDGRLEVSYDLG-------SGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDg 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1015809736  289 EHRHHfharGEFNL-----MNLDYEISFGGIPAPGKSVS-FPHR-NFHGCLENLYYNGV 340
Cdd:pfam00054   74 EARPT----GESPLgattdLDVDGPLYVGGLPSLGVKKRrLAISpSFDGCIRDVIVNGK 128
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 592-633 4.15e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 50.64  E-value: 4.15e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1015809736  592 SCEAYKHRGNT--SGFYYIDSDGSGPLEPFLLYCNMTET--AWTII 633
Cdd:NF040941     1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCDMTTDggGWTLV 46
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 552-583 7.65e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 7.65e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1015809736  552 CLPNYCEHGGECSQSWSTFHCNCTnTGYRGAT 583
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 1006-1128 1.88e-04

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 43.89  E-value: 1.88e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  1006 GSSVIYNFQENyllsKNSSSHAASFHgDMKLSREM-IKFSFRTTRTPSLLLF--VSSFYKEYLSVIIakNGSLQI---RY 1079
Cdd:smart00210   25 PGSPAYRLGDP----ALVPQPTRDLF-PSGLPEDFsLLTTFRQTPKSRGVLFaiYDAQNVRQFGLEV--DGRANTlllRY 97

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*....
gi 1015809736  1080 KLNKyQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEIDDNRRRQVHL 1128
Cdd:smart00210   98 QGVD-GKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPL 145
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 591-638 2.78e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 43.77  E-value: 2.78e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1015809736  591 QSC-EAYKHRGNTSGFYYIDSDGSgpLEPFLLYCNMTET--AWTIIQH--NGS 638
Cdd:cd00087      4 RDCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDTDggGWTVIQRrgDGS 54
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 594-642 4.36e-04

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 43.03  E-value: 4.36e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1015809736   594 EAYKHRGNTSGFYYIDSDGSGplEPFLLYCNMTETA--WTIIQH--NGS-DLTR 642
Cdd:smart00186    7 DVLQNGGKTSGLYTIYPDGSS--RPLKVYCDMETDGggWTVIQRrmDGSvDFYR 58
COLFI smart00038
Fibrillar collagens C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia ...
 603-686 4.90e-04

Fibrillar collagens C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.


Pssm-ID: 197483  Cd Length: 232  Bit Score: 43.23  E-value: 4.90e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736   603 SGFYYIDSDGSGPLEPFLLYCNMtETAWTIIQHNGSDLTRVRNTNPENPYAGF---------FEYVAS----MEQLQATI 669
Cdd:smart00038   44 SGEYWVDPNQGCIRDAIKVFCNF-ETGETCVSPSPSSIPRKTWYSGKSKHVWFgetmnggfkFSYGDSegppVGVVQLTF 122

                            90
                    ....*....|....*....
gi 1015809736   670 NR--AEHCEQEFTYYCKKS 686
Cdd:smart00038  123 LRllSTEAHQNITYHCKNS 141
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 415-494 7.02e-04

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 41.60  E-value: 7.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809736  415 SGGILLFL-SDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFG 493
Cdd:pfam13385   43 GGGYSLGLdGDGRLRFAVNGGNGGWDTVTSGASVPLGQWTHVAVTYDGGTLRLYVNGVLVGSSTLTGGPPPGTGGPLYIG 122


                   .
gi 1015809736  494 G 494
Cdd:pfam13385  123 R 123
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 961-995 1.48e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.48e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1015809736  961 CSSYGkLCRNGGKCRERPIGFFCDCTfSAYTGPFC 995
Cdd:cd00054      5 CASGN-PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 550-584 1.94e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.94e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1015809736  550 DRCL-PNYCEHGGECSQSWSTFHCNCTNtGYRGATC 584
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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