NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1009287518|ref|NP_001308350|]
View 

rho GDP-dissociation inhibitor 2 [Homo sapiens]

Protein Classification

rho GDP-dissociation inhibitor( domain architecture ID 10489308)

rho GDP-dissociation inhibitor (Rho GDI) regulates the GDP/GTP exchange reaction of the rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Rho_GDI pfam02115
RHO protein GDP dissociation inhibitor;
23-198 2.48e-92

RHO protein GDP dissociation inhibitor;


:

Pssm-ID: 460449  Cd Length: 191  Bit Score: 267.95  E-value: 2.48e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287518  23 NYKPPPQKSLKELQEMDKDDESLIKYKKTLLGDGPVVTDPKAPNVVVTRLTLVCESAPG-PITMDLTGDLEALKKETIVL 101
Cdd:pfam02115  15 NYKLGPQKSLKEQLELDKDDESLRRWKEQLLGAVDVADEPNEPEVVILSLTILSPGRPDiVLPLPLTGDLEFKKKPWFTL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287518 102 KEGSEYRVKIHFKVNRDIVSGLKYVQHTYRTGVKVDKATFMVGSYGPRPEEYEFLTPVEEAPKGMLARGTYHNKSFFTDD 181
Cdd:pfam02115  95 KEGSEYRLKISFKVSNNIVSGLKYVQTVWKTGVKVDKTKEMLGSYSPQEEPYTYTTPEEEAPSGMFARGSYSAKSKFVDD 174

                         170
                  ....*....|....*..
gi 1009287518 182 DKQDHLSWEWNLSIKKE 198
Cdd:pfam02115 175 DKKCHLEWNWTFEIKKD 191
 
Name Accession Description Interval E-value
Rho_GDI pfam02115
RHO protein GDP dissociation inhibitor;
23-198 2.48e-92

RHO protein GDP dissociation inhibitor;


Pssm-ID: 460449  Cd Length: 191  Bit Score: 267.95  E-value: 2.48e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287518  23 NYKPPPQKSLKELQEMDKDDESLIKYKKTLLGDGPVVTDPKAPNVVVTRLTLVCESAPG-PITMDLTGDLEALKKETIVL 101
Cdd:pfam02115  15 NYKLGPQKSLKEQLELDKDDESLRRWKEQLLGAVDVADEPNEPEVVILSLTILSPGRPDiVLPLPLTGDLEFKKKPWFTL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287518 102 KEGSEYRVKIHFKVNRDIVSGLKYVQHTYRTGVKVDKATFMVGSYGPRPEEYEFLTPVEEAPKGMLARGTYHNKSFFTDD 181
Cdd:pfam02115  95 KEGSEYRLKISFKVSNNIVSGLKYVQTVWKTGVKVDKTKEMLGSYSPQEEPYTYTTPEEEAPSGMFARGSYSAKSKFVDD 174

                         170
                  ....*....|....*..
gi 1009287518 182 DKQDHLSWEWNLSIKKE 198
Cdd:pfam02115 175 DKKCHLEWNWTFEIKKD 191
 
Name Accession Description Interval E-value
Rho_GDI pfam02115
RHO protein GDP dissociation inhibitor;
23-198 2.48e-92

RHO protein GDP dissociation inhibitor;


Pssm-ID: 460449  Cd Length: 191  Bit Score: 267.95  E-value: 2.48e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287518  23 NYKPPPQKSLKELQEMDKDDESLIKYKKTLLGDGPVVTDPKAPNVVVTRLTLVCESAPG-PITMDLTGDLEALKKETIVL 101
Cdd:pfam02115  15 NYKLGPQKSLKEQLELDKDDESLRRWKEQLLGAVDVADEPNEPEVVILSLTILSPGRPDiVLPLPLTGDLEFKKKPWFTL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1009287518 102 KEGSEYRVKIHFKVNRDIVSGLKYVQHTYRTGVKVDKATFMVGSYGPRPEEYEFLTPVEEAPKGMLARGTYHNKSFFTDD 181
Cdd:pfam02115  95 KEGSEYRLKISFKVSNNIVSGLKYVQTVWKTGVKVDKTKEMLGSYSPQEEPYTYTTPEEEAPSGMFARGSYSAKSKFVDD 174

                         170
                  ....*....|....*..
gi 1009287518 182 DKQDHLSWEWNLSIKKE 198
Cdd:pfam02115 175 DKKCHLEWNWTFEIKKD 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH