distal membrane-arm assembly complex protein 2 isoform 11 [Homo sapiens]
Protein Classification
leucine-rich repeat domain-containing protein( domain architecture ID 1563018)
leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| AMN1 super family | cl39120 | Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ... |
107-168 | 6.89e-05 | ||
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model. The actual alignment was detected with superfamily member cd09293: Pssm-ID: 187754 [Multi-domain] Cd Length: 226 Bit Score: 41.54 E-value: 6.89e-05
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| DUF3685 super family | cl13838 | Protein of unknown function (DUF3685); This domain family is found in bacteria and eukaryotes, ... |
41-74 | 4.69e-03 | ||
Protein of unknown function (DUF3685); This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. There are two completely conserved residues (L and D) that may be functionally important. The actual alignment was detected with superfamily member pfam12452: Pssm-ID: 432564 Cd Length: 192 Bit Score: 35.93 E-value: 4.69e-03
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| Name | Accession | Description | Interval | E-value | ||
| AMN1 | cd09293 | Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ... |
107-168 | 6.89e-05 | ||
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model. Pssm-ID: 187754 [Multi-domain] Cd Length: 226 Bit Score: 41.54 E-value: 6.89e-05
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| CReP_N | pfam10472 | eIF2-alpha phosphatase phosphorylation constitutive repressor; This is the conserved ... |
120-172 | 1.87e-03 | ||
eIF2-alpha phosphatase phosphorylation constitutive repressor; This is the conserved N-terminal domain of CReP, constitutive repressor of eIF2-alpha phosphorylation/protein phosphatase 1, catalytic subunit. It functions in the dephosphorylation of eIF2-alpha under basal conditions in the absence of stress. In response to translation inhibition, there is reduced synthesis of the labile CReP that contributes to elevated levels of eIF2-alpha phosphorylation. The C-terminus, family PP1c, is shared with the apoptosis-associated protein Gadd34 and herpes simplex virus. Pssm-ID: 371074 Cd Length: 411 Bit Score: 37.87 E-value: 1.87e-03
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| DUF3685 | pfam12452 | Protein of unknown function (DUF3685); This domain family is found in bacteria and eukaryotes, ... |
41-74 | 4.69e-03 | ||
Protein of unknown function (DUF3685); This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. There are two completely conserved residues (L and D) that may be functionally important. Pssm-ID: 432564 Cd Length: 192 Bit Score: 35.93 E-value: 4.69e-03
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| Name | Accession | Description | Interval | E-value | ||
| AMN1 | cd09293 | Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ... |
107-168 | 6.89e-05 | ||
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model. Pssm-ID: 187754 [Multi-domain] Cd Length: 226 Bit Score: 41.54 E-value: 6.89e-05
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| CReP_N | pfam10472 | eIF2-alpha phosphatase phosphorylation constitutive repressor; This is the conserved ... |
120-172 | 1.87e-03 | ||
eIF2-alpha phosphatase phosphorylation constitutive repressor; This is the conserved N-terminal domain of CReP, constitutive repressor of eIF2-alpha phosphorylation/protein phosphatase 1, catalytic subunit. It functions in the dephosphorylation of eIF2-alpha under basal conditions in the absence of stress. In response to translation inhibition, there is reduced synthesis of the labile CReP that contributes to elevated levels of eIF2-alpha phosphorylation. The C-terminus, family PP1c, is shared with the apoptosis-associated protein Gadd34 and herpes simplex virus. Pssm-ID: 371074 Cd Length: 411 Bit Score: 37.87 E-value: 1.87e-03
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| PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
112-172 | 4.17e-03 | ||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 36.30 E-value: 4.17e-03
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| DUF3685 | pfam12452 | Protein of unknown function (DUF3685); This domain family is found in bacteria and eukaryotes, ... |
41-74 | 4.69e-03 | ||
Protein of unknown function (DUF3685); This domain family is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. There are two completely conserved residues (L and D) that may be functionally important. Pssm-ID: 432564 Cd Length: 192 Bit Score: 35.93 E-value: 4.69e-03
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