NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1000232083|ref|NP_001307338|]
View 

mitochondrial inner membrane protease ATP23 homolog isoform c [Homo sapiens]

Protein Classification

mitochondrial inner membrane protease ATP23( domain architecture ID 10561080)

mitochondrial inner membrane protease ATP23 is an M76 family metallopeptidase that has a dual role in the assembly of mitochondrial ATPase: acting as a protease that removes the N-terminal 10 residues of mitochondrial ATPase CF(o) subunit 6 (ATP6) at the intermembrane space side; and is also involved in the correct assembly of the membrane-embedded ATPase CF(o) particle

EC:  3.4.24.-
Gene Ontology:  GO:0004222|GO:0034982|GO:0046872|GO:0033615
MEROPS:  M76

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Peptidase_M76 pfam09768
Peptidase M76 family; This is a family of metalloproteases. Proteins in this family are also ...
 1-102 5.56e-57

Peptidase M76 family; This is a family of metalloproteases. Proteins in this family are also annotated as Ku70-binding proteins.


:

Pssm-ID: 430811  Cd Length: 168  Bit Score: 174.27  E-value: 5.56e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232083   1 MNRVVTHELIHAFDHCRAHVDWfTNIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISK 80
Cdd:pfam09768  68 LEDTLAHELIHAYDHCRFKVDW-KNLRHHACSEIRAANLSGDCRFKRELLRGGFKFTKQHQECVKRRAILSVMANPNCKD 146

                          90       100
                  ....*....|....*....|..
gi 1000232083  81 EVAKKAVDEVFESCFNDHEPFG 102
Cdd:pfam09768 147 KEAEKAVNEVFDSCFNDTRPFD 168
 
Name Accession Description Interval E-value
Peptidase_M76 pfam09768
Peptidase M76 family; This is a family of metalloproteases. Proteins in this family are also ...
 1-102 5.56e-57

Peptidase M76 family; This is a family of metalloproteases. Proteins in this family are also annotated as Ku70-binding proteins.


Pssm-ID: 430811  Cd Length: 168  Bit Score: 174.27  E-value: 5.56e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232083   1 MNRVVTHELIHAFDHCRAHVDWfTNIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISK 80
Cdd:pfam09768  68 LEDTLAHELIHAYDHCRFKVDW-KNLRHHACSEIRAANLSGDCRFKRELLRGGFKFTKQHQECVKRRAILSVMANPNCKD 146

                          90       100
                  ....*....|....*....|..
gi 1000232083  81 EVAKKAVDEVFESCFNDHEPFG 102
Cdd:pfam09768 147 KEAEKAVNEVFDSCFNDTRPFD 168
 
Name Accession Description Interval E-value
Peptidase_M76 pfam09768
Peptidase M76 family; This is a family of metalloproteases. Proteins in this family are also ...
 1-102 5.56e-57

Peptidase M76 family; This is a family of metalloproteases. Proteins in this family are also annotated as Ku70-binding proteins.


Pssm-ID: 430811  Cd Length: 168  Bit Score: 174.27  E-value: 5.56e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000232083   1 MNRVVTHELIHAFDHCRAHVDWfTNIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISK 80
Cdd:pfam09768  68 LEDTLAHELIHAYDHCRFKVDW-KNLRHHACSEIRAANLSGDCRFKRELLRGGFKFTKQHQECVKRRAILSVMANPNCKD 146

                          90       100
                  ....*....|....*....|..
gi 1000232083  81 EVAKKAVDEVFESCFNDHEPFG 102
Cdd:pfam09768 147 KEAEKAVNEVFDSCFNDTRPFD 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH