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Conserved domains on  [gi|987996599|ref|NP_001306973|]
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sterol regulatory element-binding protein cleavage-activating protein isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 53-197 6.49e-57

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


:

Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 193.18  E-value: 6.49e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599    53 MVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSS 132
Cdd:pfam12349    1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 987996599   133 ESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADL 197
Cdd:pfam12349   81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRL 145
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 822-979 2.63e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 107.04  E-value: 2.63e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  822 HQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVS 898
Cdd:cd00200     8 HTGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVaASADGTYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  899 HVFAHRGDVTSLTCTTSC--VISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISDNLLVTGGQ--GCVSFWDLNYG 974
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSqdGTIKLWDLRTG 167


                  ....*
gi 987996599  975 DLLQT 979
Cdd:cd00200   168 KCVAT 172
WD40 COG2319
WD40 repeat [General function prediction only];
637-979 6.44e-23

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 6.44e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  637 PEPRHRAVCGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSLAWAPSAEGSIWS 716
Cdd:COG2319     4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  717 LELQ--GNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLD--KRIVAARLNGSLDFFSLETHTALSPLqfRGT 792
Cdd:COG2319    84 VAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTL--TGH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  793 PGRGSSPA-SP----VYSSS--------DTVACHLTHTVPcAHQKPITALK-AAAGR-LVTGSQDHTLRVFRLEDSCCLF 857
Cdd:COG2319   162 SGAVTSVAfSPdgklLASGSddgtvrlwDLATGKLLRTLT-GHTGAVRSVAfSPDGKlLASGSADGTVRLWDLATGKLLR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  858 TLQGHSGAITTVYI--DQTMvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRST 933
Cdd:COG2319   241 TLTGHSGSVRSVAFspDGRL-LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPdgKLLASGSDDGTVRLWDLAT 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 987996599  934 GIKFYSIQQDLGCGASLGVISD-NLLVTGGQ-GCVSFWDLNYGDLLQT 979
Cdd:COG2319   320 GKLLRTLTGHTGAVRSVAFSPDgKTLASGSDdGTVRLWDLATGELLRT 367
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 516-547 1.78e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


:

Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.78e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 987996599    516 VLRGHLMDIECLA--SDGMLLVSCCLAGHVCVWD 547
Cdd:smart00320    7 TLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 53-197 6.49e-57

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 193.18  E-value: 6.49e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599    53 MVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSS 132
Cdd:pfam12349    1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 987996599   133 ESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADL 197
Cdd:pfam12349   81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRL 145
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 822-979 2.63e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.04  E-value: 2.63e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  822 HQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVS 898
Cdd:cd00200     8 HTGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVaASADGTYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  899 HVFAHRGDVTSLTCTTSC--VISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISDNLLVTGGQ--GCVSFWDLNYG 974
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSqdGTIKLWDLRTG 167


                  ....*
gi 987996599  975 DLLQT 979
Cdd:cd00200   168 KCVAT 172
WD40 COG2319
WD40 repeat [General function prediction only];
637-979 6.44e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 6.44e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  637 PEPRHRAVCGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSLAWAPSAEGSIWS 716
Cdd:COG2319     4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  717 LELQ--GNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLD--KRIVAARLNGSLDFFSLETHTALSPLqfRGT 792
Cdd:COG2319    84 VAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTL--TGH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  793 PGRGSSPA-SP----VYSSS--------DTVACHLTHTVPcAHQKPITALK-AAAGR-LVTGSQDHTLRVFRLEDSCCLF 857
Cdd:COG2319   162 SGAVTSVAfSPdgklLASGSddgtvrlwDLATGKLLRTLT-GHTGAVRSVAfSPDGKlLASGSADGTVRLWDLATGKLLR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  858 TLQGHSGAITTVYI--DQTMvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRST 933
Cdd:COG2319   241 TLTGHSGSVRSVAFspDGRL-LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPdgKLLASGSDDGTVRLWDLAT 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 987996599  934 GIKFYSIQQDLGCGASLGVISD-NLLVTGGQ-GCVSFWDLNYGDLLQT 979
Cdd:COG2319   320 GKLLRTLTGHTGAVRSVAFSPDgKTLASGSDdGTVRLWDLATGELLRT 367
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 10-211 9.22e-21

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 98.83  E-value: 9.22e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599    10 SLRAESLVHVHFKEEiGVAELIPLVTTYIILFAYIY----FSTR-KIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGL 84
Cdd:TIGR00917  555 SFSAERSIEDELKRE-STADVITIAISYLVMFAYISltlgDSPRlKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGL 633

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599    85 TPTLNGGEIFPYLVVVIGLENVLVLTKSV-----------VSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYF 153
Cdd:TIGR00917  634 KSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqvgVDNEQELTLERRLSRALMEVGPSITLASLSEILAFALGAL 713

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 987996599   154 TLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMEladlNKRLPPEACLPSAK 211
Cdd:TIGR00917  714 IKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTE----DKRVDCFPCIKTSK 767
WD40 COG2319
WD40 repeat [General function prediction only];
716-979 3.48e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.13  E-value: 3.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  716 SLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNGSLDFFSLETHTALSPLQFRGTPGR 795
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  796 G-----SSPASPVYSSSD-------TVACHLTHTVPCAHQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQG 861
Cdd:COG2319    81 VlsvafSPDGRLLASASAdgtvrlwDLATGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  862 HSGAITTVYI--DQTMvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRSTGIKF 937
Cdd:COG2319   161 HSGAVTSVAFspDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKLLASGSADGTVRLWDLATGKLL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 987996599  938 YSIQQDLGCGASLGVISDN-LLVTGGQ-GCVSFWDLNYGDLLQT 979
Cdd:COG2319   240 RTLTGHSGSVRSVAFSPDGrLLASGSAdGTVRLWDLATGELLRT 283
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 852-890 1.45e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.45e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 987996599    852 DSCCLFTLQGHSGAITTVYIDQT-MVLASGGQDGAICLWD 890
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
855-890 6.49e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 6.49e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 987996599   855 CLFTLQGHSGAITTVYIDQT-MVLASGGQDGAICLWD 890
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVWD 39
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
30-187 8.45e-04

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 43.31  E-value: 8.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599   30 LIPLVTTYIILFAYIYFstrkidmvKSKWGLALAaVVTVLSSLLMSVGLCTLFG--LTPTLNggeIFPYLVVVIGLENVL 107
Cdd:COG1033   223 FFPLALLLILLLLFLFF--------RSLRGVLLP-LLVVLLAVIWTLGLMGLLGipLSPLTI---LVPPLLLAIGIDYGI 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  108 -VLTKsvvstpvdleVKLRIAQGLSSESwsIMKNMATELGI-IL-------IGYFTL----VPAIQEFCLFAVVGLVSDF 174
Cdd:COG1033   291 hLLNR----------YREERRKGLDKRE--ALREALRKLGPpVLltslttaIGFLSLlfsdIPPIRDFGIVAAIGVLLAF 358

                         170
                  ....*....|...
gi 987996599  175 FLQMLFFTTVLSI 187
Cdd:COG1033   359 LTSLTLLPALLSL 371
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 516-547 1.78e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.78e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 987996599    516 VLRGHLMDIECLA--SDGMLLVSCCLAGHVCVWD 547
Cdd:smart00320    7 TLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 516-558 3.27e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 3.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 987996599  516 VLRGHLMDIECLA--SDGMLLVSCCLAGHVCVWDAQTGDCLTRIP 558
Cdd:cd00200   214 TLRGHENGVNSVAfsPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258
 
Name Accession Description Interval E-value
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 53-197 6.49e-57

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 193.18  E-value: 6.49e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599    53 MVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSS 132
Cdd:pfam12349    1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGE 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 987996599   133 ESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADL 197
Cdd:pfam12349   81 VGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRL 145
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 822-979 2.63e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.04  E-value: 2.63e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  822 HQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVS 898
Cdd:cd00200     8 HTGGVTCVAFSPdgKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVaASADGTYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  899 HVFAHRGDVTSLTCTTSC--VISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISDNLLVTGGQ--GCVSFWDLNYG 974
Cdd:cd00200    88 TLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSqdGTIKLWDLRTG 167


                  ....*
gi 987996599  975 DLLQT 979
Cdd:cd00200   168 KCVAT 172
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 711-979 4.79e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.49  E-value: 4.79e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  711 EGSIWSLEL--QGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFL--DKRIVAARLNGSLDFFSLEThtalsp 786
Cdd:cd00200     9 TGGVTCVAFspDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDLET------ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  787 lqfrgtpgrgsspaspvysssdtvaCHLTHTVPCaHQKPITALKAAAGR--LVTGSQDHTLRVFRLEDSCCLFTLQGHSG 864
Cdd:cd00200    83 -------------------------GECVRTLTG-HTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTD 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  865 AITTVYIDQT-MVLASGGQDGAICLWDVLTGSRVsHVF-AHRGDVTSLTC--TTSCVISSGLDDLISIWDRSTGIKFYSI 940
Cdd:cd00200   137 WVNSVAFSPDgTFVASSSQDGTIKLWDLRTGKCV-ATLtGHTGEVNSVAFspDGEKLLSSSSDGTIKLWDLSTGKCLGTL 215

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 987996599  941 QQDLGCGASLGVISDNLLVTGG--QGCVSFWDLNYGDLLQT 979
Cdd:cd00200   216 RGHENGVNSVAFSPDGYLLASGseDGTIRVWDLRTGECVQT 256
WD40 COG2319
WD40 repeat [General function prediction only];
637-979 6.44e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.68  E-value: 6.44e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  637 PEPRHRAVCGRSRDSPGYDFSCLVQRVYQEEGLAAVCTPALRPPSPGPVLSQAPEDEGGSPEKGSPSLAWAPSAEGSIWS 716
Cdd:COG2319     4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  717 LELQ--GNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLD--KRIVAARLNGSLDFFSLETHTALSPLqfRGT 792
Cdd:COG2319    84 VAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTL--TGH 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  793 PGRGSSPA-SP----VYSSS--------DTVACHLTHTVPcAHQKPITALK-AAAGR-LVTGSQDHTLRVFRLEDSCCLF 857
Cdd:COG2319   162 SGAVTSVAfSPdgklLASGSddgtvrlwDLATGKLLRTLT-GHTGAVRSVAfSPDGKlLASGSADGTVRLWDLATGKLLR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  858 TLQGHSGAITTVYI--DQTMvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRST 933
Cdd:COG2319   241 TLTGHSGSVRSVAFspDGRL-LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPdgKLLASGSDDGTVRLWDLAT 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 987996599  934 GIKFYSIQQDLGCGASLGVISD-NLLVTGGQ-GCVSFWDLNYGDLLQT 979
Cdd:COG2319   320 GKLLRTLTGHTGAVRSVAFSPDgKTLASGSDdGTVRLWDLATGELLRT 367
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 10-211 9.22e-21

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 98.83  E-value: 9.22e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599    10 SLRAESLVHVHFKEEiGVAELIPLVTTYIILFAYIY----FSTR-KIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGL 84
Cdd:TIGR00917  555 SFSAERSIEDELKRE-STADVITIAISYLVMFAYISltlgDSPRlKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGL 633

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599    85 TPTLNGGEIFPYLVVVIGLENVLVLTKSV-----------VSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYF 153
Cdd:TIGR00917  634 KSTLIIMEVIPFLVLAVGVDNIFILVFFYfyleyfyrqvgVDNEQELTLERRLSRALMEVGPSITLASLSEILAFALGAL 713

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 987996599   154 TLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMEladlNKRLPPEACLPSAK 211
Cdd:TIGR00917  714 IKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTE----DKRVDCFPCIKTSK 767
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 720-930 2.07e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 2.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  720 QGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKR--IVAARLNGSLDFFSLETHTALSPLQFRGTPGRG- 796
Cdd:cd00200    62 DGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSv 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  797 -SSPASPVYSSS---------DTVACHLTHTVPcAHQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQGHSG 864
Cdd:cd00200   142 aFSPDGTFVASSsqdgtiklwDLRTGKCVATLT-GHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN 220

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 987996599  865 AITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTC--TTSCVISSGLDDLISIWD 930
Cdd:cd00200   221 GVNSVaFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWspDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
716-979 3.48e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.13  E-value: 3.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  716 SLELQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFLDKRIVAARLNGSLDFFSLETHTALSPLQFRGTPGR 795
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  796 G-----SSPASPVYSSSD-------TVACHLTHTVPCAHQKPITALKAAA--GRLVTGSQDHTLRVFRLEDSCCLFTLQG 861
Cdd:COG2319    81 VlsvafSPDGRLLASASAdgtvrlwDLATGLLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  862 HSGAITTVYI--DQTMvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLISIWDRSTGIKF 937
Cdd:COG2319   161 HSGAVTSVAFspDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKLLASGSADGTVRLWDLATGKLL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 987996599  938 YSIQQDLGCGASLGVISDN-LLVTGGQ-GCVSFWDLNYGDLLQT 979
Cdd:COG2319   240 RTLTGHSGSVRSVAFSPDGrLLASGSAdGTVRLWDLATGELLRT 283
WD40 COG2319
WD40 repeat [General function prediction only];
711-933 2.63e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.43  E-value: 2.63e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  711 EGSIWSLEL--QGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFL--DKRIVAARLNGSLDFFSLETHTALSP 786
Cdd:COG2319   162 SGAVTSVAFspDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRT 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  787 LqfRGTPGRGSSPA-SP-----VYSSSDTVAC-------HLTHTVPcAHQKPITALKAAA-GR-LVTGSQDHTLRVFRLE 851
Cdd:COG2319   242 L--TGHSGSVRSVAfSPdgrllASGSADGTVRlwdlatgELLRTLT-GHSGGVNSVAFSPdGKlLASGSDDGTVRLWDLA 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  852 DSCCLFTLQGHSGAITTVYI---DQTmvLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCTT--SCVISSGLDDLI 926
Cdd:COG2319   319 TGKLLRTLTGHTGAVRSVAFspdGKT--LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSADGTV 396


                  ....*..
gi 987996599  927 SIWDRST 933
Cdd:COG2319   397 RLWDLAT 403
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 29-278 9.11e-18

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 88.57  E-value: 9.11e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599    29 ELIP-LVTTYIILFAY-----IYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLtPTLNGGEIFPYLVVVIG 102
Cdd:pfam02460  214 TLTPfFVIGFFLLLTFsiivsVTLSSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGF-PFNSIVCVTPFLVLAIG 292

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599   103 LENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFT 182
Cdd:pfam02460  293 VDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFA 372

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599   183 TVLSIdirrMELADLNKRLPPEACLPSakpvgQPTRYERQLAVRPSTPHTITLQPSSFRNLRLPkrlrvvyFLARTRLaq 262
Cdd:pfam02460  373 AIMAI----CAKPEAEGRHCLFVWATS-----SPQRIDSEGSEPDKSHNIEQLKSRFFLDIYCP-------FLLNPSV-- 434

                          250
                   ....*....|....*..
gi 987996599   263 RLIMAGT-VVWIGILVY 278
Cdd:pfam02460  435 RVCMLVLfVVYIAIAIY 451
WD40 COG2319
WD40 repeat [General function prediction only];
703-891 1.60e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 1.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  703 SLAWAPsaegsiwslelQGNLIVVGRSSGRLEVWDAIEGVLCCSSEEVSSGITALVFL--DKRIVAARLNGSLDFFSLET 780
Cdd:COG2319   209 SVAFSP-----------DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLWDLAT 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  781 HTALSPLqfRGTPGRGSSPA-SP-----VYSSSDTVAC-------HLTHTVPcAHQKPITALKAAA--GRLVTGSQDHTL 845
Cdd:COG2319   278 GELLRTL--TGHSGGVNSVAfSPdgkllASGSDDGTVRlwdlatgKLLRTLT-GHTGAVRSVAFSPdgKTLASGSDDGTV 354

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 987996599  846 RVFRLEDSCCLFTLQGHSGAITTVYI--DQTMvLASGGQDGAICLWDV 891
Cdd:COG2319   355 RLWDLATGELLRTLTGHTGAVTSVAFspDGRT-LASGSADGTVRLWDL 401
2A060605 TIGR00920
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, ...
 21-187 8.24e-14

3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273339 [Multi-domain]  Cd Length: 886  Bit Score: 76.05  E-value: 8.24e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599    21 FKEEIGVAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPT-LNggEIFPYLVV 99
Cdd:TIGR00920   53 FEEEYLSSDVIVMTITRCIAVLYIYYQFCNLRQLGSKYILGIAGLFTIFSSFVFSTAVIHFLGSELTgLN--EALPFFLL 130

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599   100 VIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQML 179
Cdd:TIGR00920  131 LIDLSKASALAKFALSSNSQDEVRDNIARGMAILGPTITLDTVVETLVIGVGTMSGVRRLEVLCCFGCMSVLANYFVFMT 210


                   ....*...
gi 987996599   180 FFTTVLSI 187
Cdd:TIGR00920  211 FFPACLSL 218
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
31-236 9.28e-14

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 76.07  E-value: 9.28e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599    31 IPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLT 110
Cdd:TIGR00918  400 IRIVSGYLLMLAYACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLA 479

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599   111 KSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIR 190
Cdd:TIGR00918  480 HAFSETGQNIPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLR 559

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 987996599   191 RMEladlNKRLPPEACL--PSAKPVGQ--PTRYERQLAVRPSTPH-TITLQ 236
Cdd:TIGR00918  560 RRE----DRRLDIFCCFfsPCSARVIQiePQAYADGSAPPVYSSHmQSTVQ 606
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 855-979 5.46e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.83  E-value: 5.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  855 CLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDVLTGSRVSHVFAHRGDVTSLTCT--TSCVISSGLDDLISIWDR 931
Cdd:cd00200     1 LRRTLKGHTGGVTCVaFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 987996599  932 STGIKFYSIQQDLGCGASLGVISDNLLVTGG--QGCVSFWDLNYGDLLQT 979
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSsrDKTIKVWDVETGKCLTT 130
WD40 COG2319
WD40 repeat [General function prediction only];
813-980 2.63e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.86  E-value: 2.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  813 HLTHTVPCAHQKPITALKAAAGRLVTGSQDHTLRVFRLEDSCCLFTLQGHSGAITTV-YIDQTMVLASGGQDGAICLWDV 891
Cdd:COG2319    28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVaFSPDGRLLASASADGTVRLWDL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  892 LTGSRVSHVFAHRGDVTSLTCT--TSCVISSGLDDLISIWDRSTGIKFYSIQQDLGCGASLGVISD-NLLVTGGQ-GCVS 967
Cdd:COG2319   108 ATGLLLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgKLLASGSDdGTVR 187

                         170
                  ....*....|...
gi 987996599  968 FWDLNYGDLLQTV 980
Cdd:COG2319   188 LWDLATGKLLRTL 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 852-890 1.45e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 1.45e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 987996599    852 DSCCLFTLQGHSGAITTVYIDQT-MVLASGGQDGAICLWD 890
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
855-890 6.49e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 6.49e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 987996599   855 CLFTLQGHSGAITTVYIDQT-MVLASGGQDGAICLWD 890
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVWD 39
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
30-187 8.45e-04

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 43.31  E-value: 8.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599   30 LIPLVTTYIILFAYIYFstrkidmvKSKWGLALAaVVTVLSSLLMSVGLCTLFG--LTPTLNggeIFPYLVVVIGLENVL 107
Cdd:COG1033   223 FFPLALLLILLLLFLFF--------RSLRGVLLP-LLVVLLAVIWTLGLMGLLGipLSPLTI---LVPPLLLAIGIDYGI 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 987996599  108 -VLTKsvvstpvdleVKLRIAQGLSSESwsIMKNMATELGI-IL-------IGYFTL----VPAIQEFCLFAVVGLVSDF 174
Cdd:COG1033   291 hLLNR----------YREERRKGLDKRE--ALREALRKLGPpVLltslttaIGFLSLlfsdIPPIRDFGIVAAIGVLLAF 358

                         170
                  ....*....|...
gi 987996599  175 FLQMLFFTTVLSI 187
Cdd:COG1033   359 LTSLTLLPALLSL 371
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 516-547 1.78e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.78e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 987996599    516 VLRGHLMDIECLA--SDGMLLVSCCLAGHVCVWD 547
Cdd:smart00320    7 TLKGHTGPVTSVAfsPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 516-558 3.27e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 3.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 987996599  516 VLRGHLMDIECLA--SDGMLLVSCCLAGHVCVWDAQTGDCLTRIP 558
Cdd:cd00200   214 TLRGHENGVNSVAfsPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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