NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|973184624|ref|NP_001305637|]
View 

regulator of MON1-CCZ1 complex isoform 4 [Homo sapiens]

Protein Classification

Mic1 family protein( domain architecture ID 6327)

Mic1 family protein similar to Homo sapiens regulator of MON1-CCZ1 complex, which is a componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF) and acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization

Gene Ontology:  GO:0010506|GO:0006914|GO:0035658

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Mic1 super family cl06189
Colon cancer-associated protein Mic1-like; This family represents the C-terminus ...
 318-401 4.81e-40

Colon cancer-associated protein Mic1-like; This family represents the C-terminus (approximately 160 residues) of a number of proteins that resemble colon cancer-associated protein Mic1.


The actual alignment was detected with superfamily member pfam07035:

Pssm-ID: 429257  Cd Length: 157  Bit Score: 140.84  E-value: 4.81e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973184624  318 PHKFVIAVLMEYIRSLNQFQIAVQHYLHELVIKTLVQHNLFYMLHQFLQYHVLSDSKPLACLLLSLESFYPPAHQLSLDM 397
Cdd:pfam07035   1 DSSYLVAVLMEYLRSLSKYEIPVQHYLYELLINLLVRNKRFYQLHQFVQYHVLTDSKPLACLLLSLENVYPPAFQLALDM 80


                  ....
gi 973184624  398 LKML 401
Cdd:pfam07035  81 LKRL 84
 
Name Accession Description Interval E-value
Mic1 pfam07035
Colon cancer-associated protein Mic1-like; This family represents the C-terminus ...
 318-401 4.81e-40

Colon cancer-associated protein Mic1-like; This family represents the C-terminus (approximately 160 residues) of a number of proteins that resemble colon cancer-associated protein Mic1.


Pssm-ID: 429257  Cd Length: 157  Bit Score: 140.84  E-value: 4.81e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973184624  318 PHKFVIAVLMEYIRSLNQFQIAVQHYLHELVIKTLVQHNLFYMLHQFLQYHVLSDSKPLACLLLSLESFYPPAHQLSLDM 397
Cdd:pfam07035   1 DSSYLVAVLMEYLRSLSKYEIPVQHYLYELLINLLVRNKRFYQLHQFVQYHVLTDSKPLACLLLSLENVYPPAFQLALDM 80


                  ....
gi 973184624  398 LKML 401
Cdd:pfam07035  81 LKRL 84
 
Name Accession Description Interval E-value
Mic1 pfam07035
Colon cancer-associated protein Mic1-like; This family represents the C-terminus ...
 318-401 4.81e-40

Colon cancer-associated protein Mic1-like; This family represents the C-terminus (approximately 160 residues) of a number of proteins that resemble colon cancer-associated protein Mic1.


Pssm-ID: 429257  Cd Length: 157  Bit Score: 140.84  E-value: 4.81e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 973184624  318 PHKFVIAVLMEYIRSLNQFQIAVQHYLHELVIKTLVQHNLFYMLHQFLQYHVLSDSKPLACLLLSLESFYPPAHQLSLDM 397
Cdd:pfam07035   1 DSSYLVAVLMEYLRSLSKYEIPVQHYLYELLINLLVRNKRFYQLHQFVQYHVLTDSKPLACLLLSLENVYPPAFQLALDM 80


                  ....
gi 973184624  398 LKML 401
Cdd:pfam07035  81 LKRL 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH