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Conserved domains on  [gi|972777515|ref|NP_001305462|]
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tetratricopeptide repeat protein 12 isoform 1 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
105-212 8.59e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.72  E-value: 8.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515 105 LADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKSfsfmqcDEKCTKAYF 184
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALEL------DPDDAEALN 80

                         90       100
                 ....*....|....*....|....*...
gi 972777515 185 HMGKANLALKNYSVSRECYKKILEINPK 212
Cdd:COG0457   81 NLGLALQALGRYEEALEDYDKALELDPD 108
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
105-212 8.59e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.72  E-value: 8.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515 105 LADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKSfsfmqcDEKCTKAYF 184
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALEL------DPDDAEALN 80

                         90       100
                 ....*....|....*....|....*...
gi 972777515 185 HMGKANLALKNYSVSRECYKKILEINPK 212
Cdd:COG0457   81 NLGLALQALGRYEEALEDYDKALELDPD 108
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 50-199 1.91e-08

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 57.69  E-value: 1.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515   50 EDQEEDECRTTLNKTMISPPQTAMKSAEEINSEAFLASVEKDAKERakrrrenKVLADALKEKGNEAFAEGNYETAILRY 129
Cdd:TIGR00990  78 KQAEKETEGKTEEKKSTAPKNAPVEPADELPEIDESSVANLSEEER-------KKYAAKLKEKGNKAYRNKDFNKAIKLY 150

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 972777515  130 SEGLEkLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALK-SFSFMQCDEKCTKAYFHMGKANLALKNYSVS 199
Cdd:TIGR00990 151 SKAIE-CKPDPVYYSNRAACHNALGDWEKVVEDTTAALElDPDYSKALNRRANAYDGLGKYADALLDLTAS 220
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 105-261 3.05e-07

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 53.25  E-value: 3.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515 105 LADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALksfsfmQCDEKCTKAYF 184
Cdd:PLN03088   1 MAKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAI------ELDPSLAKAYL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515 185 HMGKANLALKNYSVSRECYKKILEINPKlQTQVKGYLNQVDL---QEKADLQEKEAHELLDSGKNTAVT--TKNLLETLS 259
Cdd:PLN03088  75 RKGTACMKLEEYQTAKAALEKGASLAPG-DSRFTKLIKECDEkiaEEEKDLVQPVPSDLPSSVTAPPVEeaDATPVVPPS 153


                 ..
gi 972777515 260 KP 261
Cdd:PLN03088 154 KP 155
TPR_1 pfam00515
Tetratricopeptide repeat;
143-168 8.84e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 40.10  E-value: 8.84e-05
                          10        20
                  ....*....|....*....|....*.
gi 972777515  143 YTNRAQAYMKLEDYEKALVDCEWALK 168
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALE 29
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 143-168 2.32e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 38.97  E-value: 2.32e-04
                           10        20
                   ....*....|....*....|....*.
gi 972777515   143 YTNRAQAYMKLEDYEKALVDCEWALK 168
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALE 29
BamD cd15830
BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, ...
 106-164 8.84e-03

BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, is part of the beta-barrel assembly machinery (BAM), which is essential for the folding and insertion of outer membrane proteins (OMPs) in the OM of Gram-negative bacteria. Transmembrane OMPs carry out important functions including nutrient and waste management, cell adhesion, and structural roles. The BAM complex is composed of the beta-barrel OMP BamA (also called Omp85/YaeT) and four lipoproteins BamBCDE. BamD is the only BAM lipoprotein required for viability. Both BamA and BamD are broadly distributed in Gram-negative bacteria, and may constitute the core of the BAM complex. BamD contains five Tetratricopeptide repeats (TPRs). The three TPRs at the N-terminus may participate in interaction with substrates, while the two TPRs in the C-terminus may be involved in binding with other BAM components.


Pssm-ID: 276939 [Multi-domain]  Cd Length: 213  Bit Score: 38.39  E-value: 8.84e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 972777515 106 ADALKEKGNEAFAEGNYETAIlrysEGLEKLKDMKV--LYTNRAQ-----AYMKLEDYEKALVDCE 164
Cdd:cd15830    3 AQELYEKAQTALQKGNYDGAI----KYLEALDSRYPfgPYAEQAQldliyAYYKNADYELALASAE 64
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
105-212 8.59e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 62.72  E-value: 8.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515 105 LADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKSfsfmqcDEKCTKAYF 184
Cdd:COG0457    7 DAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALEL------DPDDAEALN 80

                         90       100
                 ....*....|....*....|....*...
gi 972777515 185 HMGKANLALKNYSVSRECYKKILEINPK 212
Cdd:COG0457   81 NLGLALQALGRYEEALEDYDKALELDPD 108
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 50-199 1.91e-08

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 57.69  E-value: 1.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515   50 EDQEEDECRTTLNKTMISPPQTAMKSAEEINSEAFLASVEKDAKERakrrrenKVLADALKEKGNEAFAEGNYETAILRY 129
Cdd:TIGR00990  78 KQAEKETEGKTEEKKSTAPKNAPVEPADELPEIDESSVANLSEEER-------KKYAAKLKEKGNKAYRNKDFNKAIKLY 150

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 972777515  130 SEGLEkLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALK-SFSFMQCDEKCTKAYFHMGKANLALKNYSVS 199
Cdd:TIGR00990 151 SKAIE-CKPDPVYYSNRAACHNALGDWEKVVEDTTAALElDPDYSKALNRRANAYDGLGKYADALLDLTAS 220
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 92-212 8.05e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 51.55  E-value: 8.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515  92 AKERAKRRRENkvlADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKSfs 171
Cdd:COG4235    6 LRQALAANPND---AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL-- 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 972777515 172 fmqcDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINPK 212
Cdd:COG4235   81 ----DPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPA 117
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
106-242 9.33e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 53.86  E-value: 9.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515 106 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKSfsfmqcDEKCTKAYFH 185
Cdd:COG0457   76 AEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALEL------DPDDADALYN 149

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 972777515 186 MGKANLALKNYSVSRECYKKILEINPKLQTQVKGYLNQVDLQEKADLQEKEAHELLD 242
Cdd:COG0457  150 LGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQA 206
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 106-212 2.37e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 54.23  E-value: 2.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515 106 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALksfsfmQCDEKCTKAYFH 185
Cdd:COG3914  112 AEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRAL------ELDPDNAEALNN 185

                         90       100
                 ....*....|....*....|....*..
gi 972777515 186 MGKANLALKNYSVSRECYKKILEINPK 212
Cdd:COG3914  186 LGNALQDLGRLEEAIAAYRRALELDPD 212
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 105-261 3.05e-07

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 53.25  E-value: 3.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515 105 LADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALksfsfmQCDEKCTKAYF 184
Cdd:PLN03088   1 MAKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAI------ELDPSLAKAYL 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515 185 HMGKANLALKNYSVSRECYKKILEINPKlQTQVKGYLNQVDL---QEKADLQEKEAHELLDSGKNTAVT--TKNLLETLS 259
Cdd:PLN03088  75 RKGTACMKLEEYQTAKAALEKGASLAPG-DSRFTKLIKECDEkiaEEEKDLVQPVPSDLPSSVTAPPVEeaDATPVVPPS 153


                 ..
gi 972777515 260 KP 261
Cdd:PLN03088 154 KP 155
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 106-212 3.88e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.81  E-value: 3.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515 106 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKSfsfmqcDEKCTKAYFH 185
Cdd:COG4783   38 PEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKL------DPEHPEAYLR 111

                         90       100
                 ....*....|....*....|....*..
gi 972777515 186 MGKANLALKNYSVSRECYKKILEINPK 212
Cdd:COG4783  112 LARAYRALGRPDEAIAALEKALELDPD 138
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 82-211 7.20e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.57  E-value: 7.20e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515  82 EAFLASVEKDAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALV 161
Cdd:COG5010   30 ALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKE 109

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 972777515 162 DCEWALKSfsfmqcDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINP 211
Cdd:COG5010  110 YYEKALAL------SPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 106-243 1.30e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.50  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515 106 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKSfsfmqcDEKCTKAYFH 185
Cdd:COG2956  110 AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKL------DPDCARALLL 183

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 972777515 186 MGKANLALKNYSVSRECYKKILEINPKlqtQVKGYLNQVDLQEKADlQEKEAHELLDS 243
Cdd:COG2956  184 LAELYLEQGDYEEAIAALERALEQDPD---YLPALPRLAELYEKLG-DPEEALELLRK 237
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 106-212 2.07e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.88  E-value: 2.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515 106 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKSfsfmqcDEKCTKAYFH 185
Cdd:COG4783    4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALEL------DPDEPEARLN 77

                         90       100
                 ....*....|....*....|....*..
gi 972777515 186 MGKANLALKNYSVSRECYKKILEINPK 212
Cdd:COG4783   78 LGLALLKAGDYDEALALLEKALKLDPE 104
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
116-214 3.65e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.93  E-value: 3.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515 116 AFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALvDCEWALKSfsfmqcDEKCTKAYFHMGKANLALKN 195
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKL------DPNNAEALLNLAELLLELGD 74

                         90
                 ....*....|....*....
gi 972777515 196 YSVSRECYKKILEINPKLQ 214
Cdd:COG3063   75 YDEALAYLERALELDPSAL 93
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 90-241 5.54e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.57  E-value: 5.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515  90 KDAKERAKR-RRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALK 168
Cdd:COG2956  127 EKAIEVLERlLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALE 206

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 972777515 169 SfsfmqcDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINPklqtQVKGYLNQVDLQEKADlQEKEAHELL 241
Cdd:COG2956  207 Q------DPDYLPALPRLAELYEKLGDPEEALELLRKALELDP----SDDLLLALADLLERKE-GLEAALALL 268
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
71-212 2.72e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 46.06  E-value: 2.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515  71 TAMKSAEEINSEAFLASVEKDAKERAKRRRENKVL----ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYtNR 146
Cdd:COG4785    1 LYALALALLLALALAAAAASKAAILLAALLFAAVLalaiALADLALALAAAALAAAALAAERIDRALALPDLAQLYY-ER 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 972777515 147 AQAYMKLEDYEKALVDCEWALKSfsfmqcDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINPK 212
Cdd:COG4785   80 GVAYDSLGDYDLAIADFDQALEL------DPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPD 139
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 115-212 3.13e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 43.83  E-value: 3.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515 115 EAFAEGNYETAILRYSEGLEKLKDMKVL---YTNRAQAYMKLEDYEKALVDCEWALKSFSFmqcDEKCTKAYFHMGKANL 191
Cdd:COG1729    2 ALLKAGDYDEAIAAFKAFLKRYPNSPLApdaLYWLGEAYYALGDYDEAAEAFEKLLKRYPD---SPKAPDALLKLGLSYL 78

                         90       100
                 ....*....|....*....|.
gi 972777515 192 ALKNYSVSRECYKKILEINPK 212
Cdd:COG1729   79 ELGDYDKARATLEELIKKYPD 99
TPR_1 pfam00515
Tetratricopeptide repeat;
143-168 8.84e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 40.10  E-value: 8.84e-05
                          10        20
                  ....*....|....*....|....*.
gi 972777515  143 YTNRAQAYMKLEDYEKALVDCEWALK 168
Cdd:pfam00515   4 LYNLGNAYFKLGKYDEALEYYEKALE 29
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 143-168 2.32e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 38.97  E-value: 2.32e-04
                           10        20
                   ....*....|....*....|....*.
gi 972777515   143 YTNRAQAYMKLEDYEKALVDCEWALK 168
Cdd:smart00028   4 LYNLGNAYLKLGDYDEALEYYEKALE 29
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 106-242 5.69e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.41  E-value: 5.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515 106 ADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKSfsfmqcDEKCTKAYFH 185
Cdd:COG2956   42 VEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLEL------DPDDAEALRL 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 972777515 186 MGKANLALKNYSVSRECYKKILEINPKlQTQVKGYLNQVDLQEKadlQEKEAHELLD 242
Cdd:COG2956  116 LAEIYEQEGDWEKAIEVLERLLKLGPE-NAHAYCELAELYLEQG---DYDEAIEALE 168
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
90-160 2.28e-03

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 40.25  E-value: 2.28e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 972777515  90 KDAKERAKRRR--ENKV-LADALkekgneaFAEGNYETAILRYSEGLEKL--KDMKVLYtNRAQAYMKLEDYEKAL 160
Cdd:COG4700   77 RELEKALEFADtvQNRVrLADAL-------LELGRYDEAIELYEEALTGIfaDDPHILL-GLAQALFELGRYAEAL 144
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 76-242 3.85e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 40.36  E-value: 3.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515  76 AEEINSEAFLASVEKDAKERAKRRRENKVLADALKEKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLED 155
Cdd:COG3914   14 AAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGR 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515 156 YEKALVDCEWALksfsfmQCDEKCTKAYFHMGKANLALKNYSVSRECYKKILEINPKLqtqVKGYLNQVDLQEKADlQEK 235
Cdd:COG3914   94 YEEALALYRRAL------ALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDF---AEAYLNLGEALRRLG-RLE 163


                 ....*..
gi 972777515 236 EAHELLD 242
Cdd:COG3914  164 EAIAALR 170
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 111-212 4.44e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.71  E-value: 4.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515 111 EKGNEAFAEGNYETAILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKSfsfmqcDEKCTKAYFHMGKAN 190
Cdd:COG2956   13 FKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLER------DPDRAEALLELAQDY 86

                         90       100
                 ....*....|....*....|..
gi 972777515 191 LALKNYSVSRECYKKILEINPK 212
Cdd:COG2956   87 LKAGLLDRAEELLEKLLELDPD 108
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 48-211 4.91e-03

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 40.35  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515   48 MEEDQEEDEcrttlnKTMISPPQTAMKSAEEINSEAFlasvEKDAKERAKRRRENKV---LADALKEKGNEAFAEGNYET 124
Cdd:TIGR00990 280 LEDSNELDE------ETGNGQLQLGLKSPESKADESY----EEAARAFEKALDLGKLgekEAIALNLRGTFKCLKGKHLE 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972777515  125 AILRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALKSfsfmqcDEKCTKAYFHMGKANLALKNYSVSRECYK 204
Cdd:TIGR00990 350 ALADLSKSIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKL------NSEDPDIYYHRAQLHFIKGEFAQAGKDYQ 423


                  ....*..
gi 972777515  205 KILEINP 211
Cdd:TIGR00990 424 KSIDLDP 430
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
106-168 5.68e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.69  E-value: 5.68e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 972777515 106 ADALKEKGNEAFAEGNYETAIlRYSEGLEKLKDMKVLYTNRAQAYMKLEDYEKALVDCEWALK 168
Cdd:COG3063   26 ADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALE 87
BamD cd15830
BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, ...
 106-164 8.84e-03

BamD lipoprotein, a component of the beta-barrel assembly machinery; BamD, also called YfiO, is part of the beta-barrel assembly machinery (BAM), which is essential for the folding and insertion of outer membrane proteins (OMPs) in the OM of Gram-negative bacteria. Transmembrane OMPs carry out important functions including nutrient and waste management, cell adhesion, and structural roles. The BAM complex is composed of the beta-barrel OMP BamA (also called Omp85/YaeT) and four lipoproteins BamBCDE. BamD is the only BAM lipoprotein required for viability. Both BamA and BamD are broadly distributed in Gram-negative bacteria, and may constitute the core of the BAM complex. BamD contains five Tetratricopeptide repeats (TPRs). The three TPRs at the N-terminus may participate in interaction with substrates, while the two TPRs in the C-terminus may be involved in binding with other BAM components.


Pssm-ID: 276939 [Multi-domain]  Cd Length: 213  Bit Score: 38.39  E-value: 8.84e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 972777515 106 ADALKEKGNEAFAEGNYETAIlrysEGLEKLKDMKV--LYTNRAQ-----AYMKLEDYEKALVDCE 164
Cdd:cd15830    3 AQELYEKAQTALQKGNYDGAI----KYLEALDSRYPfgPYAEQAQldliyAYYKNADYELALASAE 64
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 181-212 8.98e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 34.42  E-value: 8.98e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 972777515  181 KAYFHMGKANLALKNYSVSRECYKKILEINPK 212
Cdd:pfam07719   2 EALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
TPR_1 pfam00515
Tetratricopeptide repeat;
181-212 9.17e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 34.32  E-value: 9.17e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 972777515  181 KAYFHMGKANLALKNYSVSRECYKKILEINPK 212
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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