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Conserved domains on  [gi|964750909|ref|NP_001304892|]
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periodic tryptophan protein 1 homolog isoform 3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
41-250 5.41e-25

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 5.41e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909  41 EGHTDAVLDLSWN---KLirnvLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPfEAQTLISGSYDKSVALYDC 117
Cdd:COG2319  159 TGHSGAVTSVAFSpdgKL----LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909 118 RSPDESHRMWRFSGQIERVTwnhFSP-CHFLAST-DDGFVYNLDARSDKPIFTLNAHNDEISGLDLS--SQIkgcLVTAS 193
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVA---FSPdGRLLASGsADGTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKL---LASGS 307

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 964750909 194 ADKYVKIWDIlgDRPSLVHSRDMKMGVLFCSSCCPDLPFIyAFGGQKEGLRVWDIST 250
Cdd:COG2319  308 DDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLAT 361
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
41-250 5.41e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 5.41e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909  41 EGHTDAVLDLSWN---KLirnvLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPfEAQTLISGSYDKSVALYDC 117
Cdd:COG2319  159 TGHSGAVTSVAFSpdgKL----LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909 118 RSPDESHRMWRFSGQIERVTwnhFSP-CHFLAST-DDGFVYNLDARSDKPIFTLNAHNDEISGLDLS--SQIkgcLVTAS 193
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVA---FSPdGRLLASGsADGTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKL---LASGS 307

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 964750909 194 ADKYVKIWDIlgDRPSLVHSRDMKMGVLFCSSCCPDLPFIyAFGGQKEGLRVWDIST 250
Cdd:COG2319  308 DDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-202 5.57e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.87  E-value: 5.57e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909  41 EGHTDAVLDLSWNKlIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPfEAQTLISGSYDKSVALYDCRSP 120
Cdd:cd00200  132 RGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTG 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909 121 DESHRmwrFSGQIERVTWNHFSPCH--FLASTDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQIKgCLVTASADKYV 198
Cdd:cd00200  210 KCLGT---LRGHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTI 285


                 ....
gi 964750909 199 KIWD 202
Cdd:cd00200  286 RIWD 289
PTZ00420 PTZ00420
coronin; Provisional
 41-116 5.31e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 50.72  E-value: 5.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909  41 EGHTDAVLDLSWNKLIRNVLASASADNTVILWDM--------SLGKPAASLAVHTDKVQTLQFHPFEAQTLISGSYDKSV 112
Cdd:PTZ00420  71 KGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIphndesvkEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFV 150


                 ....
gi 964750909 113 ALYD 116
Cdd:PTZ00420 151 NIWD 154
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 162-202 1.11e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.11e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 964750909   162 SDKPIFTLNAHNDEISGLDLSSQIKgCLVTASADKYVKIWD 202
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
164-202 1.48e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 964750909  164 KPIFTLNAHNDEISGLDLSSQiKGCLVTASADKYVKIWD 202
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
41-250 5.41e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 5.41e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909  41 EGHTDAVLDLSWN---KLirnvLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPfEAQTLISGSYDKSVALYDC 117
Cdd:COG2319  159 TGHSGAVTSVAFSpdgKL----LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909 118 RSPDESHRMWRFSGQIERVTwnhFSP-CHFLAST-DDGFVYNLDARSDKPIFTLNAHNDEISGLDLS--SQIkgcLVTAS 193
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVA---FSPdGRLLASGsADGTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKL---LASGS 307

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 964750909 194 ADKYVKIWDIlgDRPSLVHSRDMKMGVLFCSSCCPDLPFIyAFGGQKEGLRVWDIST 250
Cdd:COG2319  308 DDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-202 5.57e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.87  E-value: 5.57e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909  41 EGHTDAVLDLSWNKlIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPfEAQTLISGSYDKSVALYDCRSP 120
Cdd:cd00200  132 RGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTG 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909 121 DESHRmwrFSGQIERVTWNHFSPCH--FLASTDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQIKgCLVTASADKYV 198
Cdd:cd00200  210 KCLGT---LRGHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTI 285


                 ....
gi 964750909 199 KIWD 202
Cdd:cd00200  286 RIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-274 1.06e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.10  E-value: 1.06e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909  41 EGHTDAVLDLSWNKlIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPFeAQTLISGSYDKSVALYDCRSP 120
Cdd:cd00200    6 KGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909 121 DESHrmwRFSGQIERVTWNHFSPCHFLAST--DDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQiKGCLVTASADKYV 198
Cdd:cd00200   84 ECVR---TLTGHTSYVSSVAFSPDGRILSSssRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909 199 KIWDIlgDRPSLVHSRDMKMGVLFCSSCCPDLPFIYAFGGQKEgLRVWDISTVSSVNE-----------AFGRRERLVLG 267
Cdd:cd00200  160 KLWDL--RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTlrghengvnsvAFSPDGYLLAS 236


                 ....*..
gi 964750909 268 SARNSSI 274
Cdd:cd00200  237 GSEDGTI 243
WD40 COG2319
WD40 repeat [General function prediction only];
41-250 4.64e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 100.37  E-value: 4.64e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909  41 EGHTDAVLDLSWN---KLirnvLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPfEAQTLISGSYDKSVALYDC 117
Cdd:COG2319  117 TGHTGAVRSVAFSpdgKT----LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDL 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909 118 RSPDESHRMWRFSGQIERVTwnhFSPC-HFLAS-TDDGFVYNLDARSDKPIFTLNAHNDEISGLDLS--SQIkgcLVTAS 193
Cdd:COG2319  192 ATGKLLRTLTGHTGAVRSVA---FSPDgKLLASgSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSpdGRL---LASGS 265

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 964750909 194 ADKYVKIWDIlgDRPSLVHSRDMKMGVLFCSSCCPDLPFIyAFGGQKEGLRVWDIST 250
Cdd:COG2319  266 ADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLAT 319
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 41-247 4.05e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.86  E-value: 4.05e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909  41 EGHTDAVLDLSWNKLIRnVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPFEaQTLISGSYDKSVALYDcrsP 120
Cdd:cd00200   90 TGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWD---L 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909 121 DESHRMWRFSGQIERVTWNHFSP--CHFLASTDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQiKGCLVTASADKYV 198
Cdd:cd00200  165 RTGKCVATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTI 243

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 964750909 199 KIWDILGDRPSLV---HSRDmkmgvLFCSSCCPDLPFIYAfGGQKEGLRVWD 247
Cdd:cd00200  244 RVWDLRTGECVQTlsgHTNS-----VTSLAWSPDGKRLAS-GSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
40-250 8.43e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.90  E-value: 8.43e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909  40 AEGHTDAVLDLSWNkLIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPfEAQTLISGSYDKSVALYDcrs 119
Cdd:COG2319   74 LLGHTAAVLSVAFS-PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWD--- 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909 120 PDESHRMWRFSGQIERVTWNHFSP-CHFLAST-DDGFVYNLDARSDKPIFTLNAHNDEISGLDLS--SQIkgcLVTASAD 195
Cdd:COG2319  149 LATGKLLRTLTGHSGAVTSVAFSPdGKLLASGsDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKL---LASGSAD 225

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 964750909 196 KYVKIWDILGDRP--SLVHSRDMKMGVLFcsscCPDLPFIyAFGGQKEGLRVWDIST 250
Cdd:COG2319  226 GTVRLWDLATGKLlrTLTGHSGSVRSVAF----SPDGRLL-ASGSADGTVRLWDLAT 277
WD40 COG2319
WD40 repeat [General function prediction only];
41-203 1.05e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.74  E-value: 1.05e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909  41 EGHTDAVLDLSWN---KLirnvLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPfEAQTLISGSYDKSVALYDC 117
Cdd:COG2319  243 TGHSGSVRSVAFSpdgRL----LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDL 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909 118 RSPDESHRMWRFSGQIERVTwnhFSPC-HFLAS-TDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQIKgCLVTASAD 195
Cdd:COG2319  318 ATGKLLRTLTGHTGAVRSVA---FSPDgKTLASgSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSAD 393


                 ....*...
gi 964750909 196 KYVKIWDI 203
Cdd:COG2319  394 GTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
40-250 3.55e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.73  E-value: 3.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909  40 AEGHTDAVLDLSWNkLIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPfEAQTLISGSYDKSVALYDCRS 119
Cdd:COG2319   32 LLGLAAAVASLAAS-PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLAT 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909 120 PDESHRMWRFSGQIERVTwnhFSP-CHFLAST-DDGFVYNLDARSDKPIFTLNAHNDEISGLDLS--SQIkgcLVTASAD 195
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVA---FSPdGKTLASGsADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSpdGKL---LASGSDD 183

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 964750909 196 KYVKIWDILGDRpsLVHSRDMKMGVLFCSSCCPDLPFIyAFGGQKEGLRVWDIST 250
Cdd:COG2319  184 GTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKLL-ASGSADGTVRLWDLAT 235
PTZ00420 PTZ00420
coronin; Provisional
 41-116 5.31e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 50.72  E-value: 5.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909  41 EGHTDAVLDLSWNKLIRNVLASASADNTVILWDM--------SLGKPAASLAVHTDKVQTLQFHPFEAQTLISGSYDKSV 112
Cdd:PTZ00420  71 KGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIphndesvkEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFV 150


                 ....
gi 964750909 113 ALYD 116
Cdd:PTZ00420 151 NIWD 154
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 50-203 7.02e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 7.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909  50 LSWNKLIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPFEAQTLISGSYDKSVALYDCRS---------- 119
Cdd:PLN00181 538 ICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQgvsigtiktk 617

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909 120 --------PDESHRMWRFsgqiervtwnhfspchflaSTDDGFVYNLDARSDK-PIFTLNAHNDEISGLDLSSQikGCLV 190
Cdd:PLN00181 618 aniccvqfPSESGRSLAF-------------------GSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDS--STLV 676

                        170
                 ....*....|...
gi 964750909 191 TASADKYVKIWDI 203
Cdd:PLN00181 677 SSSTDNTLKLWDL 689
PTZ00421 PTZ00421
coronin; Provisional
 41-138 1.05e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 1.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909  41 EGHTDAVLDLSWNKLIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHpFEAQTLISGSYDKSVALYDCRSP 120
Cdd:PTZ00421 122 QGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRDG 200

                         90       100
                 ....*....|....*....|...
gi 964750909 121 D-----ESHRmwrfSGQIERVTW 138
Cdd:PTZ00421 201 TivssvEAHA----SAKSQRCLW 219
PTZ00421 PTZ00421
coronin; Provisional
 42-242 5.24e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 5.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909  42 GHTDAVLDLSWNKLIRNVLASASADNTVILWDM-------SLGKPAASLAVHTDKVQTLQFHPFEAQTLISGSYDKSVAL 114
Cdd:PTZ00421  73 GQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNV 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909 115 YDCRSPDESHRMWRFSGQIERVTWNhFSPCHFLASTDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQIKGCLVTASA 194
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAKRKDLIITLGC 231

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 964750909 195 DK----YVKIWDILgDRPSLVHSRDMKmgvlfcSSCCPDLPF------IYAFGGQKEG 242
Cdd:PTZ00421 232 SKsqqrQIMLWDTR-KMASPYSTVDLD------QSSALFIPFfdedtnLLYIGSKGEG 282
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 162-202 1.11e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.11e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 964750909   162 SDKPIFTLNAHNDEISGLDLSSQIKgCLVTASADKYVKIWD 202
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 41-73 2.43e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.43e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 964750909    41 EGHTDAVLDLSWNKLiRNVLASASADNTVILWD 73
Cdd:smart00320   9 KGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 79-203 1.30e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.93  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 964750909  79 PAASLAVHTDKVQTLQFHPFEAQTLISGSYDKSVALYDCRSPDEShrmwrfsgqIERVTwnhfspchflastddgfvynl 158
Cdd:PTZ00420  66 PVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDES---------VKEIK--------------------- 115

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 964750909 159 darsdKPIFTLNAHNDEISGLDLSSQIKGCLVTASADKYVKIWDI 203
Cdd:PTZ00420 116 -----DPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDI 155
WD40 pfam00400
WD domain, G-beta repeat;
164-202 1.48e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.48e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 964750909  164 KPIFTLNAHNDEISGLDLSSQiKGCLVTASADKYVKIWD 202
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
41-73 1.75e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 1.75e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 964750909   41 EGHTDAVLDLSWNKLiRNVLASASADNTVILWD 73
Cdd:pfam00400   8 EGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 77-116 2.53e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 2.53e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 964750909    77 GKPAASLAVHTDKVQTLQFHPFEaQTLISGSYDKSVALYD 116
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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