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Conserved domains on  [gi|952977803|ref|NP_001304022|]
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N-alpha-acetyltransferase 60 isoform b [Homo sapiens]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11418877)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 99-178 2.75e-14

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 66.60  E-value: 2.75e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803  99 DTQVAYILSLGVVKEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYYYSIRGVL 178
Cdd:COG0456   10 GGDEAEIEDLAVDPEYRGRGIGRALLEAALERA---RERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGDDALV 86
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 99-178 2.75e-14

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 66.60  E-value: 2.75e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803  99 DTQVAYILSLGVVKEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYYYSIRGVL 178
Cdd:COG0456   10 GGDEAEIEDLAVDPEYRGRGIGRALLEAALERA---RERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGDDALV 86
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 35-162 1.09e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 60.22  E-value: 1.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803   35 SLSWEKSSREYPDSWYR---DITSNKKFFSLAATYRGAIVGMIVAEIKNRTKIHkedgdilasnfsvdtqvAYILSLGVV 111
Cdd:pfam00583   6 ELLSEEFPEPWPDEPLDlleDWDEDASEGFFVAEEDGELVGFASLSIIDDEPPV-----------------GEIEGLAVA 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 952977803  112 KEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLHVLTTNNTAINFYENRDF 162
Cdd:pfam00583  69 PEYRGKGIGTALLQALLEWA---RERGCERIFLEVAADNLAAIALYEKLGF 116
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 38-173 1.16e-07

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 49.25  E-value: 1.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803   38 WEKSSREYPDSWYRDI----TSNKKFFSLAATYRGAIVGMIVAEIknrtkIHKEdgdilasnfsvdtqvAYILSLGVVKE 113
Cdd:TIGR01575   6 LEIEAAAFAFPWTEAQfaeeLANYHLCYLLARIGGKVVGYAGVQI-----VLDE---------------AHILNIAVKPE 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803  114 FRKHGIGSLLLESLKDHISTTAqdhCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYYYS 173
Cdd:TIGR01575  66 YQGQGIGRALLRELIDEAKGRG---VNEIFLEVRVSNIAAQALYKKLGFNEIAIRRNYYP 122
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 61-145 5.02e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 40.34  E-value: 5.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803  61 SLAATYRGAIVGMIVAEIKNRTKihkedgdilasnfsvdtQVAYILSLGVVKEFRKHGIGSLLLESLKDHIsttAQDHCK 140
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGSGG-----------------DTAYIGDLAVLPEYRGKGIGSALLEAAEEEA---RERGAK 60


                 ....*
gi 952977803 141 AIYLH 145
Cdd:cd04301   61 RLRLE 65
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 99-178 2.75e-14

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 66.60  E-value: 2.75e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803  99 DTQVAYILSLGVVKEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYYYSIRGVL 178
Cdd:COG0456   10 GGDEAEIEDLAVDPEYRGRGIGRALLEAALERA---RERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGDDALV 86
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 35-162 1.09e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 60.22  E-value: 1.09e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803   35 SLSWEKSSREYPDSWYR---DITSNKKFFSLAATYRGAIVGMIVAEIKNRTKIHkedgdilasnfsvdtqvAYILSLGVV 111
Cdd:pfam00583   6 ELLSEEFPEPWPDEPLDlleDWDEDASEGFFVAEEDGELVGFASLSIIDDEPPV-----------------GEIEGLAVA 68

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 952977803  112 KEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLHVLTTNNTAINFYENRDF 162
Cdd:pfam00583  69 PEYRGKGIGTALLQALLEWA---RERGCERIFLEVAADNLAAIALYEKLGF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
22-180 2.28e-09

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 55.00  E-value: 2.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803  22 YRKAVPGGrkcgaSLSWEKSSREYPD--SWYRDITSNKkFFSLAATYRGAIVGMIVAEIknrtkihkedgdilASNFSVD 99
Cdd:COG1247   19 YNEAIAEG-----TATFETEPPSEEEreAWFAAILAPG-RPVLVAEEDGEVVGFASLGP--------------FRPRPAY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803 100 TQVAYIlSLGVVKEFRKHGIGSLLLESLKDHistTAQDHCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYYYSIRGVLK 179
Cdd:COG1247   79 RGTAEE-SIYVDPDARGRGIGRALLEALIER---ARARGYRRLVAVVLADNEASIALYEKLGFEEVGTLPEVGFKFGRWL 154


                 .
gi 952977803 180 D 180
Cdd:COG1247  155 D 155
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 62-164 2.37e-08

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 50.15  E-value: 2.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803   62 LAATYRGAIVGMIVAEIKNrtkihkedgdilasnfsvDTQVAYILSLGVVKEFRKHGIGSLLLESLKDHIsttaqdHCKA 141
Cdd:pfam13508   6 FVAEDDGKIVGFAALLPLD------------------DEGALAELRLAVHPEYRGQGIGRALLEAAEAAA------KEGG 61

                          90       100
                  ....*....|....*....|...
gi 952977803  142 IYLHVLTTNNTAINFYENRDFKQ 164
Cdd:pfam13508  62 IKLLELETTNRAAAFYEKLGFEE 84
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 62-171 5.05e-08

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 50.44  E-value: 5.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803  62 LAATYRGAIVGMIVaeiknrtkIHKEDGDilasnfsvdtqVAYILSLGVVKEFRKHGIGSLLLESLkdhISTTAQDHCKA 141
Cdd:COG0454   37 IAVDDKGEPIGFAG--------LRRLDDK-----------VLELKRLYVLPEYRGKGIGKALLEAL---LEWARERGCTA 94

                         90       100       110
                 ....*....|....*....|....*....|
gi 952977803 142 IYLHVLTTNNTAINFYENRDFKQHHYLPYY 171
Cdd:COG0454   95 LELDTLDGNPAAIRFYERLGFKEIERYVAY 124
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 99-170 8.85e-08

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 49.61  E-value: 8.85e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 952977803  99 DTQVAYILSLGVVKEFRKHGIGSLLLESLKDHisttAQDH-CKAIYLHvltTNNTAINFYENRDFKQ--HHYLPY 170
Cdd:COG1246   49 DEDLAELRSLAVHPDYRGRGIGRRLLEALLAE----ARELgLKRLFLL---TTSAAIHFYEKLGFEEidKEDLPY 116
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 38-173 1.16e-07

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 49.25  E-value: 1.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803   38 WEKSSREYPDSWYRDI----TSNKKFFSLAATYRGAIVGMIVAEIknrtkIHKEdgdilasnfsvdtqvAYILSLGVVKE 113
Cdd:TIGR01575   6 LEIEAAAFAFPWTEAQfaeeLANYHLCYLLARIGGKVVGYAGVQI-----VLDE---------------AHILNIAVKPE 65

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803  114 FRKHGIGSLLLESLKDHISTTAqdhCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYYYS 173
Cdd:TIGR01575  66 YQGQGIGRALLRELIDEAKGRG---VNEIFLEVRVSNIAAQALYKKLGFNEIAIRRNYYP 122
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 45-165 1.46e-07

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 49.19  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803   45 YPDSWYRDITSNKKFFsLAATYRGAIVGMIvaEIKNRTKIHkedgdilasnfsvdtqvayilSLGVVKEFRKHGIGSLLL 124
Cdd:pfam13673  18 SPEALRERIDQGEYFF-FVAFEGGQIVGVI--ALRDRGHIS---------------------LLFVDPDYQGQGIGKALL 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 952977803  125 ESLKDHISttaQDHCKAIYLhVLTTNNTAINFYENRDFKQH 165
Cdd:pfam13673  74 EAVEDYAE---KDGIKLSEL-TVNASPYAVPFYEKLGFRAT 110
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
60-163 6.36e-07

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 47.39  E-value: 6.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803  60 FSLAATYRGAIVGMIVAEIknrtkihkedgdilaSNFSVDTQVAYILSLGVVKEFRKHGIGSLLLESLKDHistTAQDHC 139
Cdd:COG3153   40 LSLVAEDDGEIVGHVALSP---------------VDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALEA---ARERGA 101

                         90       100
                 ....*....|....*....|....
gi 952977803 140 KAIYLHvltTNNTAINFYENRDFK 163
Cdd:COG3153  102 RAVVLL---GDPSLLPFYERFGFR 122
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
102-171 5.02e-06

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 43.74  E-value: 5.02e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803 102 VAYILSLGVVKEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYY 171
Cdd:COG3393   15 VAEISGVYTHPEYRGRGLASALVAALAREA---LARGARTPFLYVDADNPAARRLYERLGFRPVGEYATV 81
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 61-145 5.02e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 40.34  E-value: 5.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 952977803  61 SLAATYRGAIVGMIVAEIKNRTKihkedgdilasnfsvdtQVAYILSLGVVKEFRKHGIGSLLLESLKDHIsttAQDHCK 140
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGSGG-----------------DTAYIGDLAVLPEYRGKGIGSALLEAAEEEA---RERGAK 60


                 ....*
gi 952977803 141 AIYLH 145
Cdd:cd04301   61 RLRLE 65
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
110-165 4.01e-04

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 39.40  E-value: 4.01e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 952977803 110 VVKEFRKHGIGSLLLESLKDHIsttAQDHCKAIYLHVLTtnnTAINFYENRDFKQH 165
Cdd:COG2153   66 VLPEYRGQGLGRALMEAAIEEA---RERGARRIVLSAQA---HAVGFYEKLGFVPV 115
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
 101-158 8.98e-04

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 37.31  E-value: 8.98e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 952977803  101 QVAYILSLGVVKEFRKHGIGSLLLESLKDHISTTAQDhckaIYLHVLTTNNTAINFYE 158
Cdd:pfam08445  20 PGGELGALQTLPEHRRRGLGSRLVAALARGIAERGIT----PFAVVVAGNTPSRRLYE 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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