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Conserved domains on  [gi|943463129|ref|NP_001303745|]
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G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

Srw family chemoreceptor( domain architecture ID 10563412)

Srw family chemoreceptor belongs to the G-protein coupled receptor (GPCR) superfamily and plays a role in chemoreception

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
38-347 8.19e-102

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


:

Pssm-ID: 402097  Cd Length: 318  Bit Score: 303.36  E-value: 8.19e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129   38 NYEHYLSIASIFINIFHFLILIRKPLRSSSINIIMAFISIFDICSMLFRMKQSYGPSI-EYIFDPCMQSKWYFNVYLEKI 116
Cdd:pfam10324   1 KVEFILSFIGFIINIFHLIILTRKSMRTSSINIIMIGIAICDIITMLLTIYNFIPEFIiSYENSECIPPDSYLKVLLDWI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129  117 LLVVKDHSQRSSTWLLFSIALIRTLVIRNPMNPKYERLAHPPTSLFTMICINLIFGPISIATFFGSDITSQNHTSSCDPD 196
Cdd:pfam10324  81 LESLQDYSRRCSTWLGVFMALIRTLVVKNPMSNKIQKLSKPKFGLIIIIIVFILSLPISIFYYFRYEIVEVGGIWKPPPN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129  197 --------GVLFYYLDISASYKQNDGMILKIYTLINSVVSTIIPCFIFPIVTVFLVKELWKAEANRKRLFSSKKvNDSSK 268
Cdd:pfam10324 161 cagfppnyTETRYVLVVSELFTANDGLLLKIFLLIDGIFSKIIPCILLPILTILLIIELRKAKKSRKNLSSSSK-NKSDR 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 943463129  269 NTQLVLFLTCVFFIAQFPIGISIGASYFFSETPGFMIILHEISYIFSVILVANTFSHFFICIFMSSQYRAELKKSIYCR 347
Cdd:pfam10324 240 TTKLVIFMTISFFIAEFPLGISYIIQFFFTDNPGIRRILTYLSVIFSLLFTINSISHCFICFLMSSQYRKTAKKLFGCK 318
 
Name Accession Description Interval E-value
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
38-347 8.19e-102

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


Pssm-ID: 402097  Cd Length: 318  Bit Score: 303.36  E-value: 8.19e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129   38 NYEHYLSIASIFINIFHFLILIRKPLRSSSINIIMAFISIFDICSMLFRMKQSYGPSI-EYIFDPCMQSKWYFNVYLEKI 116
Cdd:pfam10324   1 KVEFILSFIGFIINIFHLIILTRKSMRTSSINIIMIGIAICDIITMLLTIYNFIPEFIiSYENSECIPPDSYLKVLLDWI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129  117 LLVVKDHSQRSSTWLLFSIALIRTLVIRNPMNPKYERLAHPPTSLFTMICINLIFGPISIATFFGSDITSQNHTSSCDPD 196
Cdd:pfam10324  81 LESLQDYSRRCSTWLGVFMALIRTLVVKNPMSNKIQKLSKPKFGLIIIIIVFILSLPISIFYYFRYEIVEVGGIWKPPPN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129  197 --------GVLFYYLDISASYKQNDGMILKIYTLINSVVSTIIPCFIFPIVTVFLVKELWKAEANRKRLFSSKKvNDSSK 268
Cdd:pfam10324 161 cagfppnyTETRYVLVVSELFTANDGLLLKIFLLIDGIFSKIIPCILLPILTILLIIELRKAKKSRKNLSSSSK-NKSDR 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 943463129  269 NTQLVLFLTCVFFIAQFPIGISIGASYFFSETPGFMIILHEISYIFSVILVANTFSHFFICIFMSSQYRAELKKSIYCR 347
Cdd:pfam10324 240 TTKLVIFMTISFFIAEFPLGISYIIQFFFTDNPGIRRILTYLSVIFSLLFTINSISHCFICFLMSSQYRKTAKKLFGCK 318
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
43-340 1.53e-33

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 126.21  E-value: 1.53e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129  43 LSIASIFINIFHFLILIRKPLRSSsINIIMAFISIFDICSMLFRMKQSygpSIEYIFDPCMQSKWYFNVYLEKILLVVKD 122
Cdd:cd14978   10 ICIFGIIGNILNLVVLTRKSMRSS-TNVYLAALAVSDILVLLSALPLF---LLPYIADYSSSFLSYFYAYFLPYIYPLAN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129 123 HSQRSSTWLLFSIALIRTLVIRNPMnpKYERLAHPPTSLFTMICINLIFGPISIATFFgsditsQNHTSSCDPDGVLFYY 202
Cdd:cd14978   86 TFQTASVWLTVALTVERYIAVCHPL--KARTWCTPRRARRVILIIIIFSLLLNLPRFF------EYEVVECENCNNNSYY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129 203 LDISASYKQNDGMILKIYTLINSVVSTIIPCFIFPIVTVFLVKELWKAEANRKRLF-----SSKKVNDSSKNTQLVLFLT 277
Cdd:cd14978  158 YVIPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRrrrrlLSRSQRRERRTTIMLIAVV 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 943463129 278 CVFFIAQFPIGISIGASYFFSETPGFMIILHeISYIFSVILVANTFSHFFICIFMSSQYRAEL 340
Cdd:cd14978  238 IVFLICNLPAGILNILEAIFGESFLSPIYQL-LGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
 
Name Accession Description Interval E-value
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
38-347 8.19e-102

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


Pssm-ID: 402097  Cd Length: 318  Bit Score: 303.36  E-value: 8.19e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129   38 NYEHYLSIASIFINIFHFLILIRKPLRSSSINIIMAFISIFDICSMLFRMKQSYGPSI-EYIFDPCMQSKWYFNVYLEKI 116
Cdd:pfam10324   1 KVEFILSFIGFIINIFHLIILTRKSMRTSSINIIMIGIAICDIITMLLTIYNFIPEFIiSYENSECIPPDSYLKVLLDWI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129  117 LLVVKDHSQRSSTWLLFSIALIRTLVIRNPMNPKYERLAHPPTSLFTMICINLIFGPISIATFFGSDITSQNHTSSCDPD 196
Cdd:pfam10324  81 LESLQDYSRRCSTWLGVFMALIRTLVVKNPMSNKIQKLSKPKFGLIIIIIVFILSLPISIFYYFRYEIVEVGGIWKPPPN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129  197 --------GVLFYYLDISASYKQNDGMILKIYTLINSVVSTIIPCFIFPIVTVFLVKELWKAEANRKRLFSSKKvNDSSK 268
Cdd:pfam10324 161 cagfppnyTETRYVLVVSELFTANDGLLLKIFLLIDGIFSKIIPCILLPILTILLIIELRKAKKSRKNLSSSSK-NKSDR 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 943463129  269 NTQLVLFLTCVFFIAQFPIGISIGASYFFSETPGFMIILHEISYIFSVILVANTFSHFFICIFMSSQYRAELKKSIYCR 347
Cdd:pfam10324 240 TTKLVIFMTISFFIAEFPLGISYIIQFFFTDNPGIRRILTYLSVIFSLLFTINSISHCFICFLMSSQYRKTAKKLFGCK 318
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
43-340 1.53e-33

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 126.21  E-value: 1.53e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129  43 LSIASIFINIFHFLILIRKPLRSSsINIIMAFISIFDICSMLFRMKQSygpSIEYIFDPCMQSKWYFNVYLEKILLVVKD 122
Cdd:cd14978   10 ICIFGIIGNILNLVVLTRKSMRSS-TNVYLAALAVSDILVLLSALPLF---LLPYIADYSSSFLSYFYAYFLPYIYPLAN 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129 123 HSQRSSTWLLFSIALIRTLVIRNPMnpKYERLAHPPTSLFTMICINLIFGPISIATFFgsditsQNHTSSCDPDGVLFYY 202
Cdd:cd14978   86 TFQTASVWLTVALTVERYIAVCHPL--KARTWCTPRRARRVILIIIIFSLLLNLPRFF------EYEVVECENCNNNSYY 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129 203 LDISASYKQNDGMILKIYTLINSVVSTIIPCFIFPIVTVFLVKELWKAEANRKRLF-----SSKKVNDSSKNTQLVLFLT 277
Cdd:cd14978  158 YVIPTLLRQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSKKRRRLLRrrrrlLSRSQRRERRTTIMLIAVV 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 943463129 278 CVFFIAQFPIGISIGASYFFSETPGFMIILHeISYIFSVILVANTFSHFFICIFMSSQYRAEL 340
Cdd:cd14978  238 IVFLICNLPAGILNILEAIFGESFLSPIYQL-LGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
43-333 7.37e-06

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 46.90  E-value: 7.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129  43 LSIASIFINIFHFLILIRKPLRSSSINIIMAFISIFDICSMLFRMkqsygPSIEYIFdpcMQSKWYFNVYLEKILLVVKD 122
Cdd:cd00637    8 IFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVI-----PFSLVSL---LLGRWWFGDALCKLLGFLQS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129 123 HSQRSSTWLLFSIALIRTLVIRNPMnpKYERLAHPPTSLFTMICINLIFGPISIATFFGSDITSQNHTSSCDPDgvlfyy 202
Cdd:cd00637   80 VSLLASILTLTAISVDRYLAIVHPL--RYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLC------ 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129 203 ldisasykQNDGMILKIYTLINSVVSTIIPCFIFPIVTVFLVKELWKAEANRKRLFSSKKVNDSSKN----TQLVLFLTC 278
Cdd:cd00637  152 --------WPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRRRRerkvTKTLLIVVV 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 943463129 279 VFFIAQFPIGISIGASYFFSETPGFMIILHEISYIFSvilVANTFSHFFICIFMS 333
Cdd:cd00637  224 VFLLCWLPYFILLLLDVFGPDPSPLPRILYFLALLLA---YLNSAINPIIYAFFN 275
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
113-337 6.85e-03

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 37.95  E-value: 6.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129 113 LEKILLVVKDHSQRSSTWLLFSIALIRTLVIRNPMnpKYERLAHPPTSLFTMICINLIFGPISIATFFGSDITSQNHTSS 192
Cdd:cd15919   74 LDKIIEVLEFSSIHTSIWITVPLTIDRYIAVCHPL--KYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWIEDYTST 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463129 193 cdpdgvlfyyldisasykqndgMILKIYTLINSVVSTIIPCFIFPIVTVFLVKELWKAEANRKRLFSSkkvndsSKNTQL 272
Cdd:cd15919  152 ----------------------SMHHVLIWIHCFTVYLVPCSIFFVLNSIIVYKLRRKSNFRLRGYST------GKTTAI 203
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 943463129 273 VLFLTCVFFIAQFPIGISIgASYFFSETPGFMIILHEISYIFSVILVANTFSHFFICIFMSSQYR 337
Cdd:cd15919  204 LFTITSIFAILWAPRIIMI-LYHLYVSPINNSWLVHIVSDIANMLALLNTAINFFLYCFISKRFR 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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