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Conserved domains on  [gi|939620362|ref|NP_001303458|]
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Suv3 helicase, isoform D [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEXQc_Suv3 cd17913
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA ...
 187-332 2.19e-93

DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome (mtEXO) with exonuclease PNP (polynucleotide phosphorylase), that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Suv3 plays a role in the RNA surveillance system in mitochondria; it regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. It also confers salinity and drought stress tolerance by maintaining both photosynthesis and antioxidant machinery, probably via an increase in plant hormone levels such as gibberellic acid (GA3), the cytokinin zeatin (Z), and indole-3-acetic acid (IAA). Suv3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


:

Pssm-ID: 350671 [Multi-domain]  Cd Length: 142  Bit Score: 287.15  E-value: 2.19e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 187 RKIVFHAGPTNSGKTYHAMERYLSAKTGVYCGPLKLLATEVYNKANERGTPCDLVTGEERKFGIseslPANHVACTVEMT 266
Cdd:cd17913    1 RKIIFHAGPTNSGKTYHALQRLKSAKSGVYCGPLRLLAWEVYERLNAEGVPCDLVTGQERREVE----GATHVSCTVEMA 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 939620362 267 SVNTPYEVAVIDEIQQIRDPQRGWAWTRAFLGLIADEVHVCGEPGALDLLQKICETTGETVEVRLY 332
Cdd:cd17913   77 SISEPYDVAVIDEIQMIGDPQRGWAWTRALLGLPAEEIHLCGDPSALPLVRKLAETTGDELEVREY 142
SF2_C_suv3 cd18805
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ...
 336-474 1.18e-73

C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


:

Pssm-ID: 350192 [Multi-domain]  Cd Length: 135  Bit Score: 235.15  E-value: 1.18e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 336 TELTVENTALGSLDNIVPGDCIVCFSKHDIYTVSREIEAR-GKEVAVIYGGLPPGTKLAQAAKFNDPANSCKVMVATDAI 414
Cdd:cd18805    1 TPLSVESKPLGSLRNLRPGDCVVAFSRKDIFSLKREIEKRtGLKCAVIYGALPPETRRQQARLFNDPESGYDVLVASDAI 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 415 GMGLNLSIRRIIFYSLIKPSMNERgereiDTISVSSALQIAGRAGRFRTQWEHGYVTAFK 474
Cdd:cd18805   81 GMGLNLNIRRVIFSSLSKFDGNEM-----RPLSPSEVKQIAGRAGRFGSHFPEGEVTTLR 135
Suv3_N pfam18114
Suv3 helical N-terminal domain; This is the N-terminal domain of Suv3 present in Homo sapiens. ...
 51-166 1.14e-66

Suv3 helical N-terminal domain; This is the N-terminal domain of Suv3 present in Homo sapiens. Suv3 is an NTP-dependent RNA/DNA helicase that is necessary for the degradation of mature mtRNAs. Suv3 has been found to interact in vitro with polynucleotide phosphorylase.


:

Pssm-ID: 436283  Cd Length: 116  Bit Score: 216.04  E-value: 1.14e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362   51 TLFKPVQVHAYVDSEDVGSELSGKLEKAELLKILNKFTQRREIKSLCNENGLDDYLQQQAFGSFRRFCIEAENLPVDLHI 130
Cdd:pfam18114   1 DLVVPVKVKPNVDDADVGEELTGSLDKDSLIKVLDEFARRPAIRQLATENGLNDKLFMQAFSSFREYCLESESLPVDLHI 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 939620362  131 TFSDITQGAGHIDDIFPYFLRHAKTVFPHLDCMDDL 166
Cdd:pfam18114  81 LLSDIIKGGGHVDDLFPYFLRHAKQVFPHLECMDDL 116
SUV3_C pfam12513
Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in ...
 614-658 2.19e-11

Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00271. The yeast mitochondrial degradosome (mtEXO) is an NTP-dependent exoribonuclease involved in mitochondrial RNA metabolism. mtEXO is made up of two subunits: an RNase (DSS1) and an RNA helicase (SUV3). These co-purify with mitochondrial ribosomes.


:

Pssm-ID: 463616  Cd Length: 47  Bit Score: 59.07  E-value: 2.19e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 939620362  614 VHLEAVFDVMDLYLWLSYRFMDLFPEAAYVRDAQKELDEIIQQGV 658
Cdd:pfam12513   1 ERLESLHKVLDLYLWLSYRFPEVFPDRELAEELKKLVEEKIEEGL 45
Suv3_C_1 pfam18147
Suv3 C-terminal domain 1; This domain is found in Suv3 present in Homo sapiens. Suv3 is an ...
 546-586 8.42e-11

Suv3 C-terminal domain 1; This domain is found in Suv3 present in Homo sapiens. Suv3 is an NTP-dependent RNA/DNA helicase that is necessary for the degradation of mature mtRNAs. Suv3 has been found to interact in vitro with polynucleotide phosphorylase. This domain makes up part of the C-terminal domain.


:

Pssm-ID: 436308  Cd Length: 41  Bit Score: 57.44  E-value: 8.42e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 939620362  546 AEMIQHVALPLRARYVFCCAPINRKMPFVCSMFLKVARQYS 586
Cdd:pfam18147   1 ADLIQPVPLSLRDRYTFCMAPVNTRDPKAVAALVEFARCYA 41
 
Name Accession Description Interval E-value
DEXQc_Suv3 cd17913
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA ...
 187-332 2.19e-93

DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome (mtEXO) with exonuclease PNP (polynucleotide phosphorylase), that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Suv3 plays a role in the RNA surveillance system in mitochondria; it regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. It also confers salinity and drought stress tolerance by maintaining both photosynthesis and antioxidant machinery, probably via an increase in plant hormone levels such as gibberellic acid (GA3), the cytokinin zeatin (Z), and indole-3-acetic acid (IAA). Suv3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350671 [Multi-domain]  Cd Length: 142  Bit Score: 287.15  E-value: 2.19e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 187 RKIVFHAGPTNSGKTYHAMERYLSAKTGVYCGPLKLLATEVYNKANERGTPCDLVTGEERKFGIseslPANHVACTVEMT 266
Cdd:cd17913    1 RKIIFHAGPTNSGKTYHALQRLKSAKSGVYCGPLRLLAWEVYERLNAEGVPCDLVTGQERREVE----GATHVSCTVEMA 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 939620362 267 SVNTPYEVAVIDEIQQIRDPQRGWAWTRAFLGLIADEVHVCGEPGALDLLQKICETTGETVEVRLY 332
Cdd:cd17913   77 SISEPYDVAVIDEIQMIGDPQRGWAWTRALLGLPAEEIHLCGDPSALPLVRKLAETTGDELEVREY 142
SF2_C_suv3 cd18805
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ...
 336-474 1.18e-73

C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350192 [Multi-domain]  Cd Length: 135  Bit Score: 235.15  E-value: 1.18e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 336 TELTVENTALGSLDNIVPGDCIVCFSKHDIYTVSREIEAR-GKEVAVIYGGLPPGTKLAQAAKFNDPANSCKVMVATDAI 414
Cdd:cd18805    1 TPLSVESKPLGSLRNLRPGDCVVAFSRKDIFSLKREIEKRtGLKCAVIYGALPPETRRQQARLFNDPESGYDVLVASDAI 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 415 GMGLNLSIRRIIFYSLIKPSMNERgereiDTISVSSALQIAGRAGRFRTQWEHGYVTAFK 474
Cdd:cd18805   81 GMGLNLNIRRVIFSSLSKFDGNEM-----RPLSPSEVKQIAGRAGRFGSHFPEGEVTTLR 135
Suv3_N pfam18114
Suv3 helical N-terminal domain; This is the N-terminal domain of Suv3 present in Homo sapiens. ...
 51-166 1.14e-66

Suv3 helical N-terminal domain; This is the N-terminal domain of Suv3 present in Homo sapiens. Suv3 is an NTP-dependent RNA/DNA helicase that is necessary for the degradation of mature mtRNAs. Suv3 has been found to interact in vitro with polynucleotide phosphorylase.


Pssm-ID: 436283  Cd Length: 116  Bit Score: 216.04  E-value: 1.14e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362   51 TLFKPVQVHAYVDSEDVGSELSGKLEKAELLKILNKFTQRREIKSLCNENGLDDYLQQQAFGSFRRFCIEAENLPVDLHI 130
Cdd:pfam18114   1 DLVVPVKVKPNVDDADVGEELTGSLDKDSLIKVLDEFARRPAIRQLATENGLNDKLFMQAFSSFREYCLESESLPVDLHI 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 939620362  131 TFSDITQGAGHIDDIFPYFLRHAKTVFPHLDCMDDL 166
Cdd:pfam18114  81 LLSDIIKGGGHVDDLFPYFLRHAKQVFPHLECMDDL 116
Dob10 COG4581
Superfamily II RNA helicase [Replication, recombination and repair];
182-493 9.68e-29

Superfamily II RNA helicase [Replication, recombination and repair];


Pssm-ID: 443638 [Multi-domain]  Cd Length: 751  Bit Score: 122.74  E-value: 9.68e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 182 ARAI-TRKIVFHAGPTNSGKTY---HAMERYLS-AKTGVYCGPLKLLATEVYNKANER--GTPCDLVTGEErkfgiSESL 254
Cdd:COG4581   34 ILALeAGRSVLVAAPTGSGKTLvaeFAIFLALArGRRSFYTAPIKALSNQKFFDLVERfgAENVGLLTGDA-----SVNP 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 255 PANHVACTVEM-------TSVNT-PYEVAVIDEIQQIRDPQRGWAWTRAFLGL------------IADevhvcgepgALD 314
Cdd:COG4581  109 DAPIVVMTTEIlrnmlyrEGADLeDVGVVVMDEFHYLADPDRGWVWEEPIIHLparvqlvllsatVGN---------AEE 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 315 LLQKICETTGETVEVR-------LY------DRLTELTVENTAL-------GSLDNIVPGDC----IVCFS--------- 361
Cdd:COG4581  180 FAEWLTRVRGETAVVVseerpvpLEfhylvtPRLFPLFRVNPELlrppsrhEVIEELDRGGLlpaiVFIFSrrgcdeaaq 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 362 ---------KHDIYTVSREIE--------ARGKE--------VAVIYGGLPPGTKLAQAAKFNdpANSCKVMVATDAIGM 416
Cdd:COG4581  260 qllsarlttKEERAEIREAIDefaedfsvLFGKTlsrllrrgIAVHHAGMLPKYRRLVEELFQ--AGLLKVVFATDTLAV 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 417 GLNLSIRRIIFYSLIKpsMNERGEREidtISVSSALQIAGRAGR--FRTQwehGYVTAFKSE--DLQTLQRILARTPEPI 492
Cdd:COG4581  338 GINMPARTVVFTKLSK--FDGERHRP---LTAREFHQIAGRAGRrgIDTE---GHVVVLAPEhdDPKKFARLASARPEPL 409


                 .
gi 939620362 493 K 493
Cdd:COG4581  410 R 410
HELICc smart00490
helicase superfamily c-terminal domain;
367-461 4.54e-13

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 64.93  E-value: 4.54e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362   367 TVSREIEARGKEVAVIYGGLPPGTKLAQAAKFNDpaNSCKVMVATDAIGMGLNL-SIRRIIFYSLikpsmnergereidT 445
Cdd:smart00490   2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNN--GKIKVLVATDVAERGLDLpGVDLVIIYDL--------------P 65

                           90
                   ....*....|....*.
gi 939620362   446 ISVSSALQIAGRAGRF 461
Cdd:smart00490  66 WSPASYIQRIGRAGRA 81
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 344-461 5.47e-12

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 63.00  E-value: 5.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362  344 ALGSLDNIVPGDCIVCFSKHdIYTVSREI--EARGKEVAVIYGGLPPGTKLAQAAKFNDpaNSCKVMVATDAIGMGLNL- 420
Cdd:pfam00271   5 ALLELLKKERGGKVLIFSQT-KKTLEAELllEKEGIKVARLHGDLSQEEREEILEDFRK--GKIDVLVATDVAERGLDLp 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 939620362  421 SIRRIIFYSLIKpsmnergereidtiSVSSALQIAGRAGRF 461
Cdd:pfam00271  82 DVDLVINYDLPW--------------NPASYIQRIGRAGRA 108
SUV3_C pfam12513
Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in ...
 614-658 2.19e-11

Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00271. The yeast mitochondrial degradosome (mtEXO) is an NTP-dependent exoribonuclease involved in mitochondrial RNA metabolism. mtEXO is made up of two subunits: an RNase (DSS1) and an RNA helicase (SUV3). These co-purify with mitochondrial ribosomes.


Pssm-ID: 463616  Cd Length: 47  Bit Score: 59.07  E-value: 2.19e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 939620362  614 VHLEAVFDVMDLYLWLSYRFMDLFPEAAYVRDAQKELDEIIQQGV 658
Cdd:pfam12513   1 ERLESLHKVLDLYLWLSYRFPEVFPDRELAEELKKLVEEKIEEGL 45
Suv3_C_1 pfam18147
Suv3 C-terminal domain 1; This domain is found in Suv3 present in Homo sapiens. Suv3 is an ...
 546-586 8.42e-11

Suv3 C-terminal domain 1; This domain is found in Suv3 present in Homo sapiens. Suv3 is an NTP-dependent RNA/DNA helicase that is necessary for the degradation of mature mtRNAs. Suv3 has been found to interact in vitro with polynucleotide phosphorylase. This domain makes up part of the C-terminal domain.


Pssm-ID: 436308  Cd Length: 41  Bit Score: 57.44  E-value: 8.42e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 939620362  546 AEMIQHVALPLRARYVFCCAPINRKMPFVCSMFLKVARQYS 586
Cdd:pfam18147   1 ADLIQPVPLSLRDRYTFCMAPVNTRDPKAVAALVEFARCYA 41
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 368-420 3.67e-05

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 47.14  E-value: 3.67e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 939620362 368 VSREIEARGKEVAVIYGGLPPGTKLAQAAKFNDPANSCKVMVATDAIGMGLNL 420
Cdd:COG0553  565 LEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNL 617
DEXDc smart00487
DEAD-like helicases superfamily;
187-302 9.31e-03

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 38.24  E-value: 9.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362   187 RKIVFHAGPTNSGKT----YHAMERYLSAKTG--VYCGPLKLLATEVYNKANERGTPCDLV-----TGEERKFGISE--S 253
Cdd:smart00487  24 LRDVILAAPTGSGKTlaalLPALEALKRGKGGrvLVLVPTRELAEQWAEELKKLGPSLGLKvvglyGGDSKREQLRKleS 103

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 939620362   254 LPANHVACTVEM--------TSVNTPYEVAVIDEIQQIRDPQRGWAWTRAFLGLIAD 302
Cdd:smart00487 104 GKTDILVTTPGRlldllendKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPKN 160
 
Name Accession Description Interval E-value
DEXQc_Suv3 cd17913
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA ...
 187-332 2.19e-93

DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome (mtEXO) with exonuclease PNP (polynucleotide phosphorylase), that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Suv3 plays a role in the RNA surveillance system in mitochondria; it regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. It also confers salinity and drought stress tolerance by maintaining both photosynthesis and antioxidant machinery, probably via an increase in plant hormone levels such as gibberellic acid (GA3), the cytokinin zeatin (Z), and indole-3-acetic acid (IAA). Suv3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350671 [Multi-domain]  Cd Length: 142  Bit Score: 287.15  E-value: 2.19e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 187 RKIVFHAGPTNSGKTYHAMERYLSAKTGVYCGPLKLLATEVYNKANERGTPCDLVTGEERKFGIseslPANHVACTVEMT 266
Cdd:cd17913    1 RKIIFHAGPTNSGKTYHALQRLKSAKSGVYCGPLRLLAWEVYERLNAEGVPCDLVTGQERREVE----GATHVSCTVEMA 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 939620362 267 SVNTPYEVAVIDEIQQIRDPQRGWAWTRAFLGLIADEVHVCGEPGALDLLQKICETTGETVEVRLY 332
Cdd:cd17913   77 SISEPYDVAVIDEIQMIGDPQRGWAWTRALLGLPAEEIHLCGDPSALPLVRKLAETTGDELEVREY 142
SF2_C_suv3 cd18805
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ...
 336-474 1.18e-73

C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350192 [Multi-domain]  Cd Length: 135  Bit Score: 235.15  E-value: 1.18e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 336 TELTVENTALGSLDNIVPGDCIVCFSKHDIYTVSREIEAR-GKEVAVIYGGLPPGTKLAQAAKFNDPANSCKVMVATDAI 414
Cdd:cd18805    1 TPLSVESKPLGSLRNLRPGDCVVAFSRKDIFSLKREIEKRtGLKCAVIYGALPPETRRQQARLFNDPESGYDVLVASDAI 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 415 GMGLNLSIRRIIFYSLIKPSMNERgereiDTISVSSALQIAGRAGRFRTQWEHGYVTAFK 474
Cdd:cd18805   81 GMGLNLNIRRVIFSSLSKFDGNEM-----RPLSPSEVKQIAGRAGRFGSHFPEGEVTTLR 135
Suv3_N pfam18114
Suv3 helical N-terminal domain; This is the N-terminal domain of Suv3 present in Homo sapiens. ...
 51-166 1.14e-66

Suv3 helical N-terminal domain; This is the N-terminal domain of Suv3 present in Homo sapiens. Suv3 is an NTP-dependent RNA/DNA helicase that is necessary for the degradation of mature mtRNAs. Suv3 has been found to interact in vitro with polynucleotide phosphorylase.


Pssm-ID: 436283  Cd Length: 116  Bit Score: 216.04  E-value: 1.14e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362   51 TLFKPVQVHAYVDSEDVGSELSGKLEKAELLKILNKFTQRREIKSLCNENGLDDYLQQQAFGSFRRFCIEAENLPVDLHI 130
Cdd:pfam18114   1 DLVVPVKVKPNVDDADVGEELTGSLDKDSLIKVLDEFARRPAIRQLATENGLNDKLFMQAFSSFREYCLESESLPVDLHI 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 939620362  131 TFSDITQGAGHIDDIFPYFLRHAKTVFPHLDCMDDL 166
Cdd:pfam18114  81 LLSDIIKGGGHVDDLFPYFLRHAKQVFPHLECMDDL 116
Dob10 COG4581
Superfamily II RNA helicase [Replication, recombination and repair];
182-493 9.68e-29

Superfamily II RNA helicase [Replication, recombination and repair];


Pssm-ID: 443638 [Multi-domain]  Cd Length: 751  Bit Score: 122.74  E-value: 9.68e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 182 ARAI-TRKIVFHAGPTNSGKTY---HAMERYLS-AKTGVYCGPLKLLATEVYNKANER--GTPCDLVTGEErkfgiSESL 254
Cdd:COG4581   34 ILALeAGRSVLVAAPTGSGKTLvaeFAIFLALArGRRSFYTAPIKALSNQKFFDLVERfgAENVGLLTGDA-----SVNP 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 255 PANHVACTVEM-------TSVNT-PYEVAVIDEIQQIRDPQRGWAWTRAFLGL------------IADevhvcgepgALD 314
Cdd:COG4581  109 DAPIVVMTTEIlrnmlyrEGADLeDVGVVVMDEFHYLADPDRGWVWEEPIIHLparvqlvllsatVGN---------AEE 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 315 LLQKICETTGETVEVR-------LY------DRLTELTVENTAL-------GSLDNIVPGDC----IVCFS--------- 361
Cdd:COG4581  180 FAEWLTRVRGETAVVVseerpvpLEfhylvtPRLFPLFRVNPELlrppsrhEVIEELDRGGLlpaiVFIFSrrgcdeaaq 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 362 ---------KHDIYTVSREIE--------ARGKE--------VAVIYGGLPPGTKLAQAAKFNdpANSCKVMVATDAIGM 416
Cdd:COG4581  260 qllsarlttKEERAEIREAIDefaedfsvLFGKTlsrllrrgIAVHHAGMLPKYRRLVEELFQ--AGLLKVVFATDTLAV 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 417 GLNLSIRRIIFYSLIKpsMNERGEREidtISVSSALQIAGRAGR--FRTQwehGYVTAFKSE--DLQTLQRILARTPEPI 492
Cdd:COG4581  338 GINMPARTVVFTKLSK--FDGERHRP---LTAREFHQIAGRAGRrgIDTE---GHVVVLAPEhdDPKKFARLASARPEPL 409


                 .
gi 939620362 493 K 493
Cdd:COG4581  410 R 410
DEAD-like_helicase_N cd17912
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
 189-310 2.15e-13

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


Pssm-ID: 350670 [Multi-domain]  Cd Length: 81  Bit Score: 66.00  E-value: 2.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 189 IVFHAGPTNSGKTYHAMERY----LSAKTGVYCGPLKLLATEVYnkanergtpcdlvtgeerkfgiseslpanhvactve 264
Cdd:cd17912    1 NILHLGPTGSGKTLVAIQKIasamSSGKSVLVVTPTKLLAHEIL------------------------------------ 44

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 939620362 265 mtsvntpyevAVIDEIQQIRDPQRGWAW-TRAFLGLIADEVHVCGEP 310
Cdd:cd17912   45 ----------IVIDEIQ*ILDPAAGWAWaTRALLGLKAEKVIGVGAT 81
HELICc smart00490
helicase superfamily c-terminal domain;
367-461 4.54e-13

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 64.93  E-value: 4.54e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362   367 TVSREIEARGKEVAVIYGGLPPGTKLAQAAKFNDpaNSCKVMVATDAIGMGLNL-SIRRIIFYSLikpsmnergereidT 445
Cdd:smart00490   2 ELAELLKELGIKVARLHGGLSQEEREEILDKFNN--GKIKVLVATDVAERGLDLpGVDLVIIYDL--------------P 65

                           90
                   ....*....|....*.
gi 939620362   446 ISVSSALQIAGRAGRF 461
Cdd:smart00490  66 WSPASYIQRIGRAGRA 81
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
 344-461 5.47e-12

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 63.00  E-value: 5.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362  344 ALGSLDNIVPGDCIVCFSKHdIYTVSREI--EARGKEVAVIYGGLPPGTKLAQAAKFNDpaNSCKVMVATDAIGMGLNL- 420
Cdd:pfam00271   5 ALLELLKKERGGKVLIFSQT-KKTLEAELllEKEGIKVARLHGDLSQEEREEILEDFRK--GKIDVLVATDVAERGLDLp 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 939620362  421 SIRRIIFYSLIKpsmnergereidtiSVSSALQIAGRAGRF 461
Cdd:pfam00271  82 DVDLVINYDLPW--------------NPASYIQRIGRAGRA 108
SUV3_C pfam12513
Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in ...
 614-658 2.19e-11

Mitochondrial degradasome RNA helicase subunit C terminal; This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00271. The yeast mitochondrial degradosome (mtEXO) is an NTP-dependent exoribonuclease involved in mitochondrial RNA metabolism. mtEXO is made up of two subunits: an RNase (DSS1) and an RNA helicase (SUV3). These co-purify with mitochondrial ribosomes.


Pssm-ID: 463616  Cd Length: 47  Bit Score: 59.07  E-value: 2.19e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 939620362  614 VHLEAVFDVMDLYLWLSYRFMDLFPEAAYVRDAQKELDEIIQQGV 658
Cdd:pfam12513   1 ERLESLHKVLDLYLWLSYRFPEVFPDRELAEELKKLVEEKIEEGL 45
Suv3_C_1 pfam18147
Suv3 C-terminal domain 1; This domain is found in Suv3 present in Homo sapiens. Suv3 is an ...
 546-586 8.42e-11

Suv3 C-terminal domain 1; This domain is found in Suv3 present in Homo sapiens. Suv3 is an NTP-dependent RNA/DNA helicase that is necessary for the degradation of mature mtRNAs. Suv3 has been found to interact in vitro with polynucleotide phosphorylase. This domain makes up part of the C-terminal domain.


Pssm-ID: 436308  Cd Length: 41  Bit Score: 57.44  E-value: 8.42e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 939620362  546 AEMIQHVALPLRARYVFCCAPINRKMPFVCSMFLKVARQYS 586
Cdd:pfam18147   1 ADLIQPVPLSLRDRYTFCMAPVNTRDPKAVAALVEFARCYA 41
BRR2 COG1204
Replicative superfamily II helicase [Replication, recombination and repair];
193-492 2.05e-08

Replicative superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440817 [Multi-domain]  Cd Length: 529  Bit Score: 57.60  E-value: 2.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 193 AGPTNSGKTYHAMERYLSA----KTGVYCGPLKLLATEVYNKANER----GTPCDLVTGEerkFGISESLPANH--VACT 262
Cdd:COG1204   44 SAPTASGKTLIAELAILKAllngGKALYIVPLRALASEKYREFKRDfeelGIKVGVSTGD---YDSDDEWLGRYdiLVAT 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 263 VE----MTSVNTP--YEVA--VIDEIQQIRDPQRG----WAWTRA--------FLGL---------IA------------ 301
Cdd:COG1204  121 PEkldsLLRNGPSwlRDVDlvVVDEAHLIDDESRGptleVLLARLrrlnpeaqIVALsatignaeeIAewldaelvksdw 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 302 ------------------DEVHVCGEPG---ALDLLQK------ICETTGETVEV--RLYDRLTELTVEnTALGSLDNIv 352
Cdd:COG1204  201 rpvplnegvlydgvlrfdDGSRRSKDPTlalALDLLEEggqvlvFVSSRRDAESLakKLADELKRRLTP-EEREELEEL- 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 353 pgdcIVCFSKHDIYTVSREIEAR--GKEVAVIYGGLPPGTKLAQAAKFNDpaNSCKVMVATDAIGMGLNLSIRRIIFYSL 430
Cdd:COG1204  279 ----AEELLEVSEETHTNEKLADclEKGVAFHHAGLPSELRRLVEDAFRE--GLIKVLVATPTLAAGVNLPARRVIIRDT 352

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 939620362 431 IKPSMNErgereidtISVSSALQIAGRAGR--FRTQWEHGYVTAFKSEDLQTLQRILARTPEPI 492
Cdd:COG1204  353 KRGGMVP--------IPVLEFKQMAGRAGRpgYDPYGEAILVAKSSDEADELFERYILGEPEPI 408
SF2_C_RecQ cd18794
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ...
 353-460 1.05e-07

C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350181 [Multi-domain]  Cd Length: 134  Bit Score: 51.44  E-value: 1.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 353 PGDC--IVCFSKHDIYTVSREIEARGKEVAVIYGGLPPGTKLAQAAKFNdpANSCKVMVATDAIGMGLNLS-IRRIIFYS 429
Cdd:cd18794   29 LGGSgiIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWL--RDKIQVIVATVAFGMGIDKPdVRFVIHYS 106

                         90       100       110
                 ....*....|....*....|....*....|.
gi 939620362 430 LIKpsmnergereidtiSVSSALQIAGRAGR 460
Cdd:cd18794  107 LPK--------------SMESYYQESGRAGR 123
SF2_C_SNF cd18793
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ...
 356-428 4.44e-06

C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350180 [Multi-domain]  Cd Length: 135  Bit Score: 46.70  E-value: 4.44e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 939620362 356 CIVcFSKH----DIytVSREIEARGKEVAVIYGGLPPGTKLAQAAKFNDPANSCKVMVATDAIGMGLNLSI-RRIIFY 428
Cdd:cd18793   30 VLI-FSQFtdtlDI--LEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAGGVGLNLTAaNRVILY 104
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
 186-292 5.83e-06

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 47.26  E-value: 5.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 186 TRKIVFHAGPTNSGKT---YHAMERYL--SAKTGVYCGPLKLLATEVYNKANERGTP----CDLVTGEERKFGisESLPA 256
Cdd:cd17921   16 SGDSVLVSAPTSSGKTliaELAILRALatSGGKAVYIAPTRALVNQKEADLRERFGPlgknVGLLTGDPSVNK--LLLAE 93

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 939620362 257 NHVA-CTVE----MTSVNT-----PYEVAVIDEIQQIRDPQRGWAW 292
Cdd:cd17921   94 ADILvATPEkldlLLRNGGerliqDVRLVVVDEAHLIGDGERGVVL 139
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
 368-420 3.67e-05

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 47.14  E-value: 3.67e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 939620362 368 VSREIEARGKEVAVIYGGLPPGTKLAQAAKFNDPANSCKVMVATDAIGMGLNL 420
Cdd:COG0553  565 LEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNL 617
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
 402-465 4.63e-05

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 42.31  E-value: 4.63e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 939620362 402 ANSCKVMVATDAIGMGL-NLSIRRIIFYSLIkpsmnergereidtISVSSALQIAGRAGRFRTQW 465
Cdd:cd18785   20 ASSLEILVATNVLGEGIdVPSLDTVIFFDPP--------------SSAASYIQRVGRAGRGGKDE 70
RecQ COG0514
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
365-491 5.45e-04

Superfamily II DNA helicase RecQ [Replication, recombination and repair];


Pssm-ID: 440280 [Multi-domain]  Cd Length: 489  Bit Score: 43.21  E-value: 5.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 365 IYTVSR--------EIEARGKEVAVIYGGLPPGTKLAQAAKFNdpANSCKVMVATDAIGMGLNLS-IRRIIFYSLikPSm 435
Cdd:COG0514  235 VYCLSRkkveelaeWLREAGIRAAAYHAGLDAEEREANQDRFL--RDEVDVIVATIAFGMGIDKPdVRFVIHYDL--PK- 309

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 939620362 436 nergereidtiSVSSALQIAGRAGRFRtqwEHGY-VTAFKSEDLQTLQRILARTPEP 491
Cdd:COG0514  310 -----------SIEAYYQEIGRAGRDG---LPAEaLLLYGPEDVAIQRFFIEQSPPD 352
SF2_C_Ski2 cd18795
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ...
 406-460 1.12e-03

C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350182 [Multi-domain]  Cd Length: 154  Bit Score: 40.23  E-value: 1.12e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 939620362 406 KVMVATDAIGMGLNLSIRRIIFYSLIKpsmneRGEREIDTISVSSALQIAGRAGR 460
Cdd:cd18795   91 KVLVATSTLAAGVNLPARTVIIKGTQR-----YDGKGYRELSPLEYLQMIGRAGR 140
DEXHc_archSki2 cd18028
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ...
 193-289 1.50e-03

DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350786 [Multi-domain]  Cd Length: 177  Bit Score: 40.40  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362 193 AGPTNSGKTYHA----MERYLSAKTGVYCGPLKLLATEVY---NKANERGTPCDLVTGEERKFGisESLPANHVACTVem 265
Cdd:cd18028   23 SIPTASGKTLIAemamVNTLLEGGKALYLVPLRALASEKYeefKKLEEIGLKVGISTGDYDEDD--EWLGDYDIIVAT-- 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 939620362 266 tsvntpYE-----------------VAVIDEIQQIRDPQRG 289
Cdd:cd18028   99 ------YEkfdsllrhspswlrdvgVVVVDEIHLISDEERG 133
DEXDc smart00487
DEAD-like helicases superfamily;
187-302 9.31e-03

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 38.24  E-value: 9.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 939620362   187 RKIVFHAGPTNSGKT----YHAMERYLSAKTG--VYCGPLKLLATEVYNKANERGTPCDLV-----TGEERKFGISE--S 253
Cdd:smart00487  24 LRDVILAAPTGSGKTlaalLPALEALKRGKGGrvLVLVPTRELAEQWAEELKKLGPSLGLKvvglyGGDSKREQLRKleS 103

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 939620362   254 LPANHVACTVEM--------TSVNTPYEVAVIDEIQQIRDPQRGWAWTRAFLGLIAD 302
Cdd:smart00487 104 GKTDILVTTPGRlldllendKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPKN 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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