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Conserved domains on  [gi|939620269|ref|NP_001303423|]
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APC-like, isoform C [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
APC_rep super family cl40092
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 294-360 5.14e-20

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


The actual alignment was detected with superfamily member pfam18797:

Pssm-ID: 465870  Cd Length: 74  Bit Score: 85.68  E-value: 5.14e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 939620269   294 SHPDEKAGRREAKVLRLLDQIVDYCSFLKTLLQS-------GGEAIADDSDRHPLAAISSLMKVSFDEEHRHAM 360
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQEShsrgpegDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 544-584 1.62e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 1.62e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 939620269   544 CEPYRQILRQHNCLAILLQQLKSESLTVVSNSCGTLWNLSA 584
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 903-926 7.12e-06

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 43.91  E-value: 7.12e-06
                           10        20
                   ....*....|....*....|....
gi 939620269   903 EKPINYCEEGTPGYFSRYDSLSSL 926
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1066-1089 2.72e-05

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 42.37  E-value: 2.72e-05
                           10        20
                   ....*....|....*....|....
gi 939620269  1066 DDLSSFNVEHTPAQFSTATSLSNL 1089
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 251-293 5.03e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.03  E-value: 5.03e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 939620269    251 NAQSCATLRRSGCMPLLVQMMHapDNDQEVRKCAGQALHNVVH 293
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK--SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1247-1270 1.51e-04

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 40.06  E-value: 1.51e-04
                           10        20
                   ....*....|....*....|....
gi 939620269  1247 DEMNKFLVEDSPCNFSVVSGLSNL 1270
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
APC_15aa pfam05972
APC 15 residue motif; This motif, known as the 15 aa repeat, is found in the APC protein ...
 757-771 2.76e-03

APC 15 residue motif; This motif, known as the 15 aa repeat, is found in the APC protein family. They are involved in binding beta-catenin along with the pfam05923 repeats. Many human cancer mutations map to the region around these motifs, and may be involved in disrupting their binding of beta-catenin.


:

Pssm-ID: 461790  Cd Length: 15  Bit Score: 36.75  E-value: 2.76e-03
                           10
                   ....*....|....*
gi 939620269   757 TEEQPIDYSVKYSEN 771
Cdd:pfam05972    1 EEDQPIDYSLKYSEE 15
 
Name Accession Description Interval E-value
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 294-360 5.14e-20

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 85.68  E-value: 5.14e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 939620269   294 SHPDEKAGRREAKVLRLLDQIVDYCSFLKTLLQS-------GGEAIADDSDRHPLAAISSLMKVSFDEEHRHAM 360
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQEShsrgpegDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 544-584 1.62e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 1.62e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 939620269   544 CEPYRQILRQHNCLAILLQQLKSESLTVVSNSCGTLWNLSA 584
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 903-926 7.12e-06

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 43.91  E-value: 7.12e-06
                           10        20
                   ....*....|....*....|....
gi 939620269   903 EKPINYCEEGTPGYFSRYDSLSSL 926
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 544-584 1.58e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 43.19  E-value: 1.58e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 939620269    544 CEPYRQILRQHNCLAILLQQLKSESLTVVSNSCGTLWNLSA 584
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1066-1089 2.72e-05

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 42.37  E-value: 2.72e-05
                           10        20
                   ....*....|....*....|....
gi 939620269  1066 DDLSSFNVEHTPAQFSTATSLSNL 1089
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 251-293 5.03e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.03  E-value: 5.03e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 939620269    251 NAQSCATLRRSGCMPLLVQMMHapDNDQEVRKCAGQALHNVVH 293
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK--SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1247-1270 1.51e-04

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 40.06  E-value: 1.51e-04
                           10        20
                   ....*....|....*....|....
gi 939620269  1247 DEMNKFLVEDSPCNFSVVSGLSNL 1270
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
APC_15aa pfam05972
APC 15 residue motif; This motif, known as the 15 aa repeat, is found in the APC protein ...
 757-771 2.76e-03

APC 15 residue motif; This motif, known as the 15 aa repeat, is found in the APC protein family. They are involved in binding beta-catenin along with the pfam05923 repeats. Many human cancer mutations map to the region around these motifs, and may be involved in disrupting their binding of beta-catenin.


Pssm-ID: 461790  Cd Length: 15  Bit Score: 36.75  E-value: 2.76e-03
                           10
                   ....*....|....*
gi 939620269   757 TEEQPIDYSVKYSEN 771
Cdd:pfam05972    1 EEDQPIDYSLKYSEE 15
 
Name Accession Description Interval E-value
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 294-360 5.14e-20

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 85.68  E-value: 5.14e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 939620269   294 SHPDEKAGRREAKVLRLLDQIVDYCSFLKTLLQS-------GGEAIADDSDRHPLAAISSLMKVSFDEEHRHAM 360
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQEShsrgpegDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 544-584 1.62e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 1.62e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 939620269   544 CEPYRQILRQHNCLAILLQQLKSESLTVVSNSCGTLWNLSA 584
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 903-926 7.12e-06

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 43.91  E-value: 7.12e-06
                           10        20
                   ....*....|....*....|....
gi 939620269   903 EKPINYCEEGTPGYFSRYDSLSSL 926
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 544-584 1.58e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 43.19  E-value: 1.58e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 939620269    544 CEPYRQILRQHNCLAILLQQLKSESLTVVSNSCGTLWNLSA 584
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1066-1089 2.72e-05

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 42.37  E-value: 2.72e-05
                           10        20
                   ....*....|....*....|....
gi 939620269  1066 DDLSSFNVEHTPAQFSTATSLSNL 1089
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 251-293 5.03e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.03  E-value: 5.03e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 939620269    251 NAQSCATLRRSGCMPLLVQMMHapDNDQEVRKCAGQALHNVVH 293
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK--SEDEEVVKEAAWALSNLSS 41
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1247-1270 1.51e-04

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 40.06  E-value: 1.51e-04
                           10        20
                   ....*....|....*....|....
gi 939620269  1247 DEMNKFLVEDSPCNFSVVSGLSNL 1270
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
APC_15aa pfam05972
APC 15 residue motif; This motif, known as the 15 aa repeat, is found in the APC protein ...
 757-771 2.76e-03

APC 15 residue motif; This motif, known as the 15 aa repeat, is found in the APC protein family. They are involved in binding beta-catenin along with the pfam05923 repeats. Many human cancer mutations map to the region around these motifs, and may be involved in disrupting their binding of beta-catenin.


Pssm-ID: 461790  Cd Length: 15  Bit Score: 36.75  E-value: 2.76e-03
                           10
                   ....*....|....*
gi 939620269   757 TEEQPIDYSVKYSEN 771
Cdd:pfam05972    1 EEDQPIDYSLKYSEE 15
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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