Transmembrane protein 180 [Caenorhabditis elegans]
Protein Classification
MFS transporter( domain architecture ID 999995)
major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| MFS super family | cl28910 | Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
70-284 | 4.34e-09 | ||||
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated. The actual alignment was detected with superfamily member cd17481: Pssm-ID: 475125 Cd Length: 429 Bit Score: 56.95 E-value: 4.34e-09
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| Name | Accession | Description | Interval | E-value | ||||
| MFS_MFSD13A | cd17481 | Major facilitator superfamily domain containing 13A; Human major facilitator superfamily ... |
70-284 | 4.34e-09 | ||||
Major facilitator superfamily domain containing 13A; Human major facilitator superfamily domain containing 13A (MFSD1A) protein is also called transmembrane protein 180. Its function is still unknown. MFSD13A belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement Pssm-ID: 341034 Cd Length: 429 Bit Score: 56.95 E-value: 4.34e-09
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| Name | Accession | Description | Interval | E-value | ||||
| MFS_MFSD13A | cd17481 | Major facilitator superfamily domain containing 13A; Human major facilitator superfamily ... |
70-284 | 4.34e-09 | ||||
Major facilitator superfamily domain containing 13A; Human major facilitator superfamily domain containing 13A (MFSD1A) protein is also called transmembrane protein 180. Its function is still unknown. MFSD13A belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement Pssm-ID: 341034 Cd Length: 429 Bit Score: 56.95 E-value: 4.34e-09
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