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Conserved domains on  [gi|922580940|ref|NP_001300040|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

serpentine receptor( domain architecture ID 366230)

serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Srd super family cl22924
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 1-233 1.91e-63

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


The actual alignment was detected with superfamily member pfam10326:

Pssm-ID: 419896  Cd Length: 307  Bit Score: 201.14  E-value: 1.91e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580940    1 MSCLMDLLFVGFFGTSMSILALHFIYRFFSVTNSRYLKIFDSWLIIPIFTVPLINGVLYMITGGIILSADAETDRFMREN 80
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580940   81 YLKVikNQTNLEDLYYMGPFFWPKLENsiTETYFSWKGAEGSLIVMGSIGLSSSIMIFFGIKGYISMNNLLAITSnsEQF 160
Cdd:pfam10326 161 LLEN--YNLDIDEVAYVGPVYYPTDEN--GSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGS--EKT 234

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 922580940  161 QNIQKQLFQALCIQTIIPVVLMHIPASAIYITIFFEKSSVIVGETLSLTIAMYPAMNPLPTIYIVQSYRKAVK 233
Cdd:pfam10326 235 RKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 1-233 1.91e-63

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 201.14  E-value: 1.91e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580940    1 MSCLMDLLFVGFFGTSMSILALHFIYRFFSVTNSRYLKIFDSWLIIPIFTVPLINGVLYMITGGIILSADAETDRFMREN 80
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580940   81 YLKVikNQTNLEDLYYMGPFFWPKLENsiTETYFSWKGAEGSLIVMGSIGLSSSIMIFFGIKGYISMNNLLAITSnsEQF 160
Cdd:pfam10326 161 LLEN--YNLDIDEVAYVGPVYYPTDEN--GSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGS--EKT 234

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 922580940  161 QNIQKQLFQALCIQTIIPVVLMHIPASAIYITIFFEKSSVIVGETLSLTIAMYPAMNPLPTIYIVQSYRKAVK 233
Cdd:pfam10326 235 RKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 1-233 1.91e-63

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 201.14  E-value: 1.91e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580940    1 MSCLMDLLFVGFFGTSMSILALHFIYRFFSVTNSRYLKIFDSWLIIPIFTVPLINGVLYMITGGIILSADAETDRFMREN 80
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580940   81 YLKVikNQTNLEDLYYMGPFFWPKLENsiTETYFSWKGAEGSLIVMGSIGLSSSIMIFFGIKGYISMNNLLAITSnsEQF 160
Cdd:pfam10326 161 LLEN--YNLDIDEVAYVGPVYYPTDEN--GSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGS--EKT 234

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 922580940  161 QNIQKQLFQALCIQTIIPVVLMHIPASAIYITIFFEKSSVIVGETLSLTIAMYPAMNPLPTIYIVQSYRKAVK 233
Cdd:pfam10326 235 RKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 11-232 3.71e-15

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 73.82  E-value: 3.71e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580940   11 GFFGTSMSILALHFIYRFFSVTNSRYL-KIFDSWLIIPIFTVPLINGVLYMITGGIILSADAETDRFMRENYLKVIKNQT 89
Cdd:pfam10319  97 SFISASYAVLLIHFIYRYLVLFNPQLTrHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETYGVDS 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580940   90 NleDLYYMGPFFWpklENSITETYFSWKGaegslIVMGSIgLSSSIMIFFGIKGYISMNNLLAITSN-SEQFQNIQKQLF 168
Cdd:pfam10319 177 M--DINMLGALYW---EASDETVFRSWLG-----ILLLTV-ISVYSIILYIVLGYKIMRKLNKMSVTmSKKTKRLQKQLL 245

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 922580940  169 QALCIQTIIPVVLMHIPAS-AIYITIFFEKSSVIVGETLSLTIAMYPAMNPLPTIYIVQSYRKAV 232
Cdd:pfam10319 246 KALIVQTIIPICISFSPCVlAWYSPIFGIDLGRWNNYLEVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 7-236 8.93e-07

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 49.08  E-value: 8.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580940    7 LLFVGFFGTSMSILALhFIYRFFSVTNSRYlKIFDSWLIIPIFTVPLINGVLYMITGGIILSADAETDRFMRENYLKVIK 86
Cdd:pfam10318  91 IGVTSLALVGVSIILL-FENRYSILFTNKK-RITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVLKKLPCLPP 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580940   87 NQTNLEDLYYMgpffwpklenSITETYFSWkgaegSLIVMGSIGLSSSIMIFFGIKGYISMNNLLAItsnSEQFQNIQKQ 166
Cdd:pfam10318 169 EFFDNPPVFVL----------AIDSTYFLI-----CIVLLILILIIQILFFVFLTIYYLFKSVKSSL---SKKTRKLQKK 230

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922580940  167 LFQALCIQTIIPVVLMHIPASAIYITIFFEKSSVIVGETLSLTIAMYPAMNPLPTIYIVQSYRKAVKDYF 236
Cdd:pfam10318 231 FFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLF 300
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 157-233 2.89e-03

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 38.30  E-value: 2.89e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 922580940  157 SEQFQNIQKQLFQALCIQTIIPvVLMHIPASAIYITIFFEKSSVIVGETLSLTIAMYPAM-NPLPTIYIVQSYRKAVK 233
Cdd:pfam10317 215 SPTTKAQHRQLIKGLTIQALLP-LFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLlDPLITIYFVTPYRRAIL 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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