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Conserved domains on  [gi|893567043|ref|NP_001297575|]
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TSC22 domain family protein 1 isoform 4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZIP_TSC22D1 cd21938
leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 ...
 905-983 9.01e-34

leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 (TSC22D1) is also called cerebral protein 2, regulatory protein TSC-22, TGFB-stimulated clone 22, or transforming growth factor beta-1-induced transcript 4 protein (TGFB1I4). It is a transcriptional repressor that was reported to be present in both the cytoplasmic and the nuclear fraction. It is activated by transcription growth factor-beta1 and other growth factors of osteoblastic cells. TSC22D1 acts on the C-type natriuretic peptide (CNP) promoter. It enhances c-Myc-mediated activation of the telomerase reverse transcriptase (TERT) promoter. This model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D1. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


:

Pssm-ID: 409278  Cd Length: 79  Bit Score: 124.49  E-value: 9.01e-34
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 893567043 905 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPP 983
Cdd:cd21938    1 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPSSSQPPGTTPQP 79
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 486-796 1.54e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567043  486 PVPLQATMSAATGIQPSPVSVVGITAAVGQQPsvsslAQPQLPYSQTAPPVQTPLPGAPPQQLQYGQQQPMVPAQIAPGH 565
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAP-----APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567043  566 GQPVTQNPTSEYVQQQQQPIFQAAlssgqsSSTGTGAGISVIPVAQAQGIQLPGQPTAVQTQPAGAAGQPigqaqtaVST 645
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDPAD------PPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP-------PPS 2849

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567043  646 VPTGGQIASIGQQANIPTAVQQPSTQVTPSVIQ-----QGAPPSSQVVLPAPTGIIHQGVQTRASSLPQQLVIAPQSTLV 720
Cdd:PHA03247 2850 LPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPvrrlaRPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQP 2929

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 893567043  721 TVPPQPQGVETVAQGVVSQQLPTGSPLPSASTISVTNQVSSAAPSGMPSVPTNLVPPQNIAQPPATQNGSLVQSVS 796
Cdd:PHA03247 2930 QPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVS 3005
 
Name Accession Description Interval E-value
ZIP_TSC22D1 cd21938
leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 ...
 905-983 9.01e-34

leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 (TSC22D1) is also called cerebral protein 2, regulatory protein TSC-22, TGFB-stimulated clone 22, or transforming growth factor beta-1-induced transcript 4 protein (TGFB1I4). It is a transcriptional repressor that was reported to be present in both the cytoplasmic and the nuclear fraction. It is activated by transcription growth factor-beta1 and other growth factors of osteoblastic cells. TSC22D1 acts on the C-type natriuretic peptide (CNP) promoter. It enhances c-Myc-mediated activation of the telomerase reverse transcriptase (TERT) promoter. This model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D1. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409278  Cd Length: 79  Bit Score: 124.49  E-value: 9.01e-34
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 893567043 905 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPP 983
Cdd:cd21938    1 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPSSSQPPGTTPQP 79
TSC22 pfam01166
TSC-22/dip/bun family;
910-956 5.81e-27

TSC-22/dip/bun family;


Pssm-ID: 460093  Cd Length: 57  Bit Score: 103.93  E-value: 5.81e-27
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 893567043  910 MDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPE 956
Cdd:pfam01166   1 MDLVKSHLMYAVREEVEVLKEQIKELEERNSQLEEENSILRANASPE 47
PHA03247 PHA03247
large tegument protein UL36; Provisional
 486-796 1.54e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567043  486 PVPLQATMSAATGIQPSPVSVVGITAAVGQQPsvsslAQPQLPYSQTAPPVQTPLPGAPPQQLQYGQQQPMVPAQIAPGH 565
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAP-----APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567043  566 GQPVTQNPTSEYVQQQQQPIFQAAlssgqsSSTGTGAGISVIPVAQAQGIQLPGQPTAVQTQPAGAAGQPigqaqtaVST 645
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDPAD------PPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP-------PPS 2849

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567043  646 VPTGGQIASIGQQANIPTAVQQPSTQVTPSVIQ-----QGAPPSSQVVLPAPTGIIHQGVQTRASSLPQQLVIAPQSTLV 720
Cdd:PHA03247 2850 LPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPvrrlaRPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQP 2929

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 893567043  721 TVPPQPQGVETVAQGVVSQQLPTGSPLPSASTISVTNQVSSAAPSGMPSVPTNLVPPQNIAQPPATQNGSLVQSVS 796
Cdd:PHA03247 2930 QPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVS 3005
PRK13169 PRK13169
DNA replication initiation control protein YabA;
923-952 1.70e-03

DNA replication initiation control protein YabA;


Pssm-ID: 183876  Cd Length: 110  Bit Score: 39.07  E-value: 1.70e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 893567043 923 EEVEVLKEQIKELIEKNSQLEQENNLLKTL 952
Cdd:PRK13169  22 KELGALKKQLAELLEENTALRLENDKLRER 51
 
Name Accession Description Interval E-value
ZIP_TSC22D1 cd21938
leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 ...
 905-983 9.01e-34

leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 (TSC22D1) is also called cerebral protein 2, regulatory protein TSC-22, TGFB-stimulated clone 22, or transforming growth factor beta-1-induced transcript 4 protein (TGFB1I4). It is a transcriptional repressor that was reported to be present in both the cytoplasmic and the nuclear fraction. It is activated by transcription growth factor-beta1 and other growth factors of osteoblastic cells. TSC22D1 acts on the C-type natriuretic peptide (CNP) promoter. It enhances c-Myc-mediated activation of the telomerase reverse transcriptase (TERT) promoter. This model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D1. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409278  Cd Length: 79  Bit Score: 124.49  E-value: 9.01e-34
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 893567043 905 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPP 983
Cdd:cd21938    1 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPSSSQPPGTTPQP 79
ZIP_TSC22D cd21936
leucine zipper domain found in the TSC22 domain family of leucine zipper transcription factors; ...
 909-956 1.09e-27

leucine zipper domain found in the TSC22 domain family of leucine zipper transcription factors; The TGF-beta-stimulated clone-22 domain (TSC22D) family includes TSC22D1-4 and similar proteins. They have diverse physiological functions, including cell growth, development, homeostasis, and immune regulation. All family members contain a conserved leucine zipper (ZIP) domain located at the C-terminus. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. In the bZIP family of transcription factors, the leucine zipper acts as a dimerization domain and the upstream basic region as a DNA-binding domain. However, DNA-binding capability of TSC22D family proteins is not obvious, due to the lack of the basic region found in the original bZIP DNA-binding domains. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409276  Cd Length: 49  Bit Score: 106.11  E-value: 1.09e-27
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 893567043 909 AMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPE 956
Cdd:cd21936    1 AMDLVKSHLMFAVREEVDVLKEQIAELEERISQLERENSLLRSNAPPE 48
ZIP_TSC22D4 cd21941
leucine zipper domain found in TSC22 domain family protein 4; TSC22 domain family protein 4 ...
 900-972 1.57e-27

leucine zipper domain found in TSC22 domain family protein 4; TSC22 domain family protein 4 (TSC22D4), also called TSC22-related-inducible leucine zipper protein 2 (TILZ2), or Tsc-22-like protein THG-1, is a transcriptional repressor that acts as a molecular determinant of insulin signalling and glucose handling. It also functions in hepatic lipid handling by regulating hepatic very-low-density-lipoprotein (VLDL) release and lipogenic gene expression. This model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D4. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409281  Cd Length: 74  Bit Score: 106.18  E-value: 1.57e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 893567043 900 VAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPA 972
Cdd:cd21941    1 VAIDNKIEQAMDLVKSHLLFAVREEVEVLKEQIKELSERNAALEQENSLLRSLATPQQLSRLQSRQPTSRKPA 73
ZIP_TSC22D3 cd21940
leucine zipper domain found in TSC22 domain family protein 3; TSC22 domain family protein 3 ...
 909-993 1.64e-27

leucine zipper domain found in TSC22 domain family protein 3; TSC22 domain family protein 3 (TSC22D3) is also called DSIP-immunoreactive peptide, protein DIP, delta sleep-inducing peptide immunoreactor, glucocorticoid-induced leucine zipper protein (GILZ), TSC-22-like protein, or TSC-22-related protein (TSC-22R). It protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, it plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, it inhibits anti-CD3-induced NFKB1 nuclear translocation. TSC22D3 contains a leucine zipper motif, a Pro/Glu rich domain, and three potential phosphorylation sites. This model corresponds to the leucine zipper (ZIP) domain. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409280  Cd Length: 81  Bit Score: 106.57  E-value: 1.64e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567043 909 AMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLqtgsPPATTQPQgtTQPPAQPAS 988
Cdd:cd21940    1 AMDLVKNHLMYAVREEVEVLKEQIKELVEKNSQLERENSLLKTLASPEQLEKFQSRL----PSEETAPE--TPLDAQPAE 74


                 ....*
gi 893567043 989 QGSGS 993
Cdd:cd21940   75 HSGGS 79
TSC22 pfam01166
TSC-22/dip/bun family;
910-956 5.81e-27

TSC-22/dip/bun family;


Pssm-ID: 460093  Cd Length: 57  Bit Score: 103.93  E-value: 5.81e-27
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 893567043  910 MDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPE 956
Cdd:pfam01166   1 MDLVKSHLMYAVREEVEVLKEQIKELEERNSQLEEENSILRANASPE 47
ZIP_TSC22D2 cd21939
leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 ...
 909-956 5.57e-22

leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 (TSC22D2), also called transforming growth factor beta-stimulated clone 22 domain family member 2, or TSC22-related-inducible leucine zipper protein 4 (TILZ4), may participate in the regulation of cell growth. It interacts with pyruvate kinase isoform M2 (PKM2) and WD repeat domain 77 (WDR77). The model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D2. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409279  Cd Length: 63  Bit Score: 90.02  E-value: 5.57e-22
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 893567043 909 AMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPE 956
Cdd:cd21939    1 AMDLVKSHLMYAVREEVEVLKEQIKELIERNSLLERENALLKSLSNND 48
ZIP_TSC22D-like cd21927
leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding ...
 910-956 7.16e-20

leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins; The family includes TGF-beta-stimulated clone-22 domain (TSC22D) leucine zipper transcription factors, TSC22D1-4, as well as c-Myc-binding protein (MycBP). TSC22D proteins have diverse physiological functions, including cell growth, development, homeostasis, and immune regulation. MycBP, also called associate of Myc 1 (AMY-1), is a novel c-Myc binding protein that may control the transcriptional activity of Myc. It stimulates the activation of E box-dependent transcription by Myc. Members of this family contain a conserved leucine zipper (ZIP) domain. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. In the bZIP family of transcription factors, the leucine zipper acts as a dimerization domain and the upstream basic region as a DNA-binding domain. However, DNA-binding capability of TSC22D family proteins is not obvious, due to the lack of the basic region found in the original bZIP DNA-binding domains. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409275  Cd Length: 51  Bit Score: 83.72  E-value: 7.16e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 893567043 910 MDLVKSHLMYAVREE--VEVLKEQIKELIEKNSQLEQENNLLKTLASPE 956
Cdd:cd21927    2 LDFLKHHLGAATPENpeIELLRLELAEMKEKYEAIVEENKKLKAKLAQY 50
ZIP_MycBP-like cd21937
leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called ...
 909-951 1.55e-05

leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called associate of Myc 1 (AMY-1), is a novel c-Myc binding protein that may control the transcriptional activity of Myc. It stimulates the activation of E box-dependent transcription by Myc. This model corresponds to the conserved region that shows high sequence similarity with the leucine zipper (ZIP) domain located at the C-terminus of TGF-beta-stimulated clone-22 domain (TSC22D) family transcription factors. The first helix of ZIP is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.


Pssm-ID: 409277 [Multi-domain]  Cd Length: 53  Bit Score: 43.31  E-value: 1.55e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 893567043 909 AMDLVKSHL--MYAVREEVEVLKEQIKELIEKNSQLEQENNLLKT 951
Cdd:cd21937    3 ALDFIKQHLgaPGPEDADVEALRLENEELKQKNEELEEENKELKA 47
PHA03247 PHA03247
large tegument protein UL36; Provisional
 486-796 1.54e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567043  486 PVPLQATMSAATGIQPSPVSVVGITAAVGQQPsvsslAQPQLPYSQTAPPVQTPLPGAPPQQLQYGQQQPMVPAQIAPGH 565
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAP-----APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567043  566 GQPVTQNPTSEYVQQQQQPIFQAAlssgqsSSTGTGAGISVIPVAQAQGIQLPGQPTAVQTQPAGAAGQPigqaqtaVST 645
Cdd:PHA03247 2783 LTRPAVASLSESRESLPSPWDPAD------PPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP-------PPS 2849

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567043  646 VPTGGQIASIGQQANIPTAVQQPSTQVTPSVIQ-----QGAPPSSQVVLPAPTGIIHQGVQTRASSLPQQLVIAPQSTLV 720
Cdd:PHA03247 2850 LPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPvrrlaRPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQP 2929

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 893567043  721 TVPPQPQGVETVAQGVVSQQLPTGSPLPSASTISVTNQVSSAAPSGMPSVPTNLVPPQNIAQPPATQNGSLVQSVS 796
Cdd:PHA03247 2930 QPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVS 3005
PRK13169 PRK13169
DNA replication initiation control protein YabA;
923-952 1.70e-03

DNA replication initiation control protein YabA;


Pssm-ID: 183876  Cd Length: 110  Bit Score: 39.07  E-value: 1.70e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 893567043 923 EEVEVLKEQIKELIEKNSQLEQENNLLKTL 952
Cdd:PRK13169  22 KELGALKKQLAELLEENTALRLENDKLRER 51
ZapB pfam06005
Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is ...
 905-950 4.38e-03

Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is required for proper Z-ring formation.


Pssm-ID: 428718 [Multi-domain]  Cd Length: 71  Bit Score: 36.86  E-value: 4.38e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 893567043  905 KIEQAMDLVkSHLmyavREEVEVLKEQIKELIEKNSQLEQENNLLK 950
Cdd:pfam06005  12 KIQAAVDTI-ALL----QMENEELKEENEELKEEANELEEENQQLK 52
PHA03247 PHA03247
large tegument protein UL36; Provisional
 568-839 4.94e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 4.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567043  568 PVTQNPTSEYVQQQQQPIFQAALSSGQSSSTGTGAGISVIPVAQAQGIQLPGQPTAVQTQPAgaagqPIGQAQTAVSTVP 647
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT-----TAGPPAPAPPAAP 2775

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567043  648 TGGQiasigqQANIPTAVQQPSTQVTPSVIQQGAPPSSQVVLPAPTGIIhQGVQTRASSLPQQLVIAPQSTLVTVPPQPQ 727
Cdd:PHA03247 2776 AAGP------PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAAL-PPAASPAGPLPPPTSAQPTAPPPPPGPPPP 2848

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567043  728 ----GVETVAQGVVSQQLPTGSPLPSASTISVTNQVSSAAPSGMPSVPTNLVPPQNIAQPPATQngSLVQSVSQSPLIAT 803
Cdd:PHA03247 2849 slplGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQ--APPPPQPQPQPPPP 2926

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 893567043  804 NINLPLAQQIPLSSTQFSTQSLAQAIGSQMEDARRP 839
Cdd:PHA03247 2927 PQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
DUF6262 pfam19776
Family of unknown function (DUF6262); This family of proteins, functionally uncharacterized, ...
 901-949 6.06e-03

Family of unknown function (DUF6262); This family of proteins, functionally uncharacterized, is found in bacteria. Proteins in this family are typically between 124 and 143 amino acids in length. Some members included in this family are hypothetical transposases, associated with transposon Tn554. There is a conserved sequence GV/LSR/K and a highly conserved tyrosine residue.


Pssm-ID: 466180 [Multi-domain]  Cd Length: 110  Bit Score: 37.60  E-value: 6.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 893567043  901 AIDNKIEQAMDLVKSH---LMYAVREEVEVLKEQIKELIEKNSQLEQENNLL 949
Cdd:pfam19776  59 ELDEAIEQQGGMVNPKreiLDMALEKRIELLKKEIKELKRENEELKKENEKL 110
PHA03378 PHA03378
EBNA-3B; Provisional
 541-823 6.80e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.44  E-value: 6.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567043 541 PGAPPQQLQYGQQQPMVPAQIAPGHGQPVTQNPTSEYVQQQQQPIFQAALSSGQSSSTGTGAGISVIPVAQAQGIQLPGQ 620
Cdd:PHA03378 669 IGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPA 748

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567043 621 PTAVQTQPAGAAGQPIGQAQTAvstvptGGQIASIGQQANIPTAVQQPSTQVTPSVIQQGAPPSSQVVLPAPTG------ 694
Cdd:PHA03378 749 AAPGRARPPAAAPGRARPPAAA------PGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGqqgptk 822

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 893567043 695 -----IIHQGVQTRASSLPQQLVIAPQSTLVTVP-PQPQGVETVAQGVV-------SQQLPTGSPLPSASTISVTNQVSS 761
Cdd:PHA03378 823 qilrqLLTGGVKRGRPSLKKPAALERQAAAGPTPsPGSGTSDKIVQAPVfyppvlqPIQVMRQLGSVRAAAASTVTQAPT 902

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 893567043 762 AAP----SGMPSVPTNLVPPQNIAQPPATQNGSLVQSVSQSPLIATNiNLPLAQQIPLSSTQFSTQ 823
Cdd:PHA03378 903 EYTgerrGVGPMHPTDIPPSKRAKTDAYVESQPPHGGQSHSFSVIWE-NVSQGQQQTLECGGTTKQ 967
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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