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Conserved domains on  [gi|890808339|ref|NP_001297533|]
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leucine-rich repeat LGI family member 2 isoform 2 precursor [Mus musculus]

Protein Classification

LRR_8 and EPTP domain-containing protein( domain architecture ID 12158096)

LRR_8 and EPTP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
107-166 1.65e-13

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 1.65e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 890808339  107 HLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKF 166
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 263-302 8.59e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 51.32  E-value: 8.59e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 890808339  263 FRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGSHIYKY 302
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 137-212 1.10e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.17  E-value: 1.10e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 890808339   137 LANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTV---SDVLCIGPPEYQEKKLNEVTSFDYEC 212
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 449-489 9.65e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 48.23  E-value: 9.65e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 890808339  449 QFVEVQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQIYQW 489
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 404-445 1.22e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.85  E-value: 1.22e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 890808339  404 KFVPHGDIPNMeDVLAVKSFRMQNTLYLSLTRFIGDSRVMRW 445
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 308-353 1.58e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.46  E-value: 1.58e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 890808339  308 KFVKFQDIEVSRiskPNDIELFEIDDETFFIIADSSkaGLSTVYKW 353
Cdd:pfam03736   1 KFVPYQTIPTRG---ARDVEPFSIGGDLFLAVANFS--GDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 216-256 3.53e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 44.00  E-value: 3.53e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 890808339  216 DFVVHQTLP-YQSVSVDTFNSKNDVYVAIAqPSMENCMVLEW 256
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 357-398 4.53e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 40.53  E-value: 4.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 890808339  357 GFYSYQSLHEWfRDTDAEFVDIDGKSHLILSSRSQVPIILQW 398
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
107-166 1.65e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 1.65e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 890808339  107 HLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKF 166
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
99-167 4.67e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 4.67e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 890808339  99 DDAFAGLFHLEYLFIEGNKIETISrNAFRGLRDLTHLSLANNHIKALPRDvFSDLDSLIELDLRGNKFE 167
Cdd:COG4886  175 PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 263-302 8.59e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 51.32  E-value: 8.59e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 890808339  263 FRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGSHIYKY 302
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 137-212 1.10e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.17  E-value: 1.10e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 890808339   137 LANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTV---SDVLCIGPPEYQEKKLNEVTSFDYEC 212
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 449-489 9.65e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 48.23  E-value: 9.65e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 890808339  449 QFVEVQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQIYQW 489
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 404-445 1.22e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.85  E-value: 1.22e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 890808339  404 KFVPHGDIPNMeDVLAVKSFRMQNTLYLSLTRFIGDSRVMRW 445
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 308-353 1.58e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.46  E-value: 1.58e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 890808339  308 KFVKFQDIEVSRiskPNDIELFEIDDETFFIIADSSkaGLSTVYKW 353
Cdd:pfam03736   1 KFVPYQTIPTRG---ARDVEPFSIGGDLFLAVANFS--GDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 216-256 3.53e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 44.00  E-value: 3.53e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 890808339  216 DFVVHQTLP-YQSVSVDTFNSKNDVYVAIAqPSMENCMVLEW 256
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 108-164 2.89e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 2.89e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 890808339 108 LEYLFIEGNKIETISrnAFRGLRDLTHLSLANNHIKALPR--DVFSDLDSLIELDLRGN 164
Cdd:cd21340  122 LRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 357-398 4.53e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 40.53  E-value: 4.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 890808339  357 GFYSYQSLHEWfRDTDAEFVDIDGKSHLILSSRSQVPIILQW 398
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRRCT smart00082
Leucine rich repeat C-terminal domain;
164-198 6.41e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.79  E-value: 6.41e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 890808339   164 NKFECDCKAKWLYLWLKMTNSTVS--DVLCIGPPEYQ 198
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLR 37
LRR smart00370
Leucine-rich repeats, outliers;
129-152 1.48e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 1.48e-03
                           10        20
                   ....*....|....*....|....
gi 890808339   129 LRDLTHLSLANNHIKALPRDVFSD 152
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
107-166 1.65e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 1.65e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 890808339  107 HLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGNKF 166
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
94-142 1.67e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.16  E-value: 1.67e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 890808339   94 FTVIRDDAFAGLFHLEYLFIEGNKIETISRNAFRGLRDLTHLSLANNHI 142
Cdd:pfam13855  13 LTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
99-167 4.67e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 4.67e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 890808339  99 DDAFAGLFHLEYLFIEGNKIETISrNAFRGLRDLTHLSLANNHIKALPRDvFSDLDSLIELDLRGNKFE 167
Cdd:COG4886  175 PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-167 6.46e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 6.46e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 890808339 100 DAFAGLFHLEYLFIEGNKIETISrNAFRGLRDLTHLSLANNHIKALPrdVFSDLDSLIELDLRGNKFE 167
Cdd:COG4886  199 EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-167 8.79e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.72  E-value: 8.79e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 890808339 100 DAFAGLFHLEYLFIEGNKIETISrNAFRGLRDLTHLSLANNHIKALPrDVFSDLDSLIELDLRGNKFE 167
Cdd:COG4886  130 EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQIT 195
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 263-302 8.59e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 51.32  E-value: 8.59e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 890808339  263 FRSYDNITGQSIVGCKAILIDDQVFVVVAQLFGGSHIYKY 302
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-177 9.92e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 9.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890808339 100 DAFAGLFHLEYLFIEGNKIETISrNAFRGLRDLTHLSLANNHIKALPrDVFSDLDSLIELDLRGNKFE------CDCKA- 172
Cdd:COG4886  107 EELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTdlpeelGNLTNl 184


                 ....*
gi 890808339 173 KWLYL 177
Cdd:COG4886  185 KELDL 189
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 137-212 1.10e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 58.17  E-value: 1.10e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 890808339   137 LANNHIKALPRDVFSDLDSLIELDLRGNKFECDCKAKWLYLWLKMTNSTV---SDVLCIGPPEYQEKKLNEVTSFDYEC 212
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQPLLGIPLLDSGC 80
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-196 1.58e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 1.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 890808339 100 DAFAGLFHLEYLFIEGNKIETISrnAFRGLRDLTHLSLANNHIKALPrdVFSDLDSLIELDLRGNKFEcDCKAKWLYLWL 179
Cdd:COG4886  222 EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLT-DLKLKELELLL 296

                         90
                 ....*....|....*..
gi 890808339 180 KMTNSTVSDVLCIGPPE 196
Cdd:COG4886  297 GLNSLLLLLLLLNLLEL 313
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 449-489 9.65e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 48.23  E-value: 9.65e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 890808339  449 QFVEVQALPSRGAMTLQPFSFKDNHYLALGSDYTFSQIYQW 489
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 404-445 1.22e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.85  E-value: 1.22e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 890808339  404 KFVPHGDIPNMeDVLAVKSFRMQNTLYLSLTRFIGDSRVMRW 445
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 308-353 1.58e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.46  E-value: 1.58e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 890808339  308 KFVKFQDIEVSRiskPNDIELFEIDDETFFIIADSSkaGLSTVYKW 353
Cdd:pfam03736   1 KFVPYQTIPTRG---ARDVEPFSIGGDLFLAVANFS--GDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 216-256 3.53e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 44.00  E-value: 3.53e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 890808339  216 DFVVHQTLP-YQSVSVDTFNSKNDVYVAIAqPSMENCMVLEW 256
Cdd:pfam03736   1 KFVPYQTIPtRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 108-164 2.89e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.55  E-value: 2.89e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 890808339 108 LEYLFIEGNKIETISrnAFRGLRDLTHLSLANNHIKALPR--DVFSDLDSLIELDLRGN 164
Cdd:cd21340  122 LRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 357-398 4.53e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 40.53  E-value: 4.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 890808339  357 GFYSYQSLHEWfRDTDAEFVDIDGKSHLILSSRSQVPIILQW 398
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 132-164 2.95e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 2.95e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 890808339  132 LTHLSLANNHIKALPrdVFSDLDSLIELDLRGN 164
Cdd:pfam12799   3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
LRRCT smart00082
Leucine rich repeat C-terminal domain;
164-198 6.41e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.79  E-value: 6.41e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 890808339   164 NKFECDCKAKWLYLWLKMTNSTVS--DVLCIGPPEYQ 198
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLR 37
LRR smart00370
Leucine-rich repeats, outliers;
129-152 1.48e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 1.48e-03
                           10        20
                   ....*....|....*....|....
gi 890808339   129 LRDLTHLSLANNHIKALPRDVFSD 152
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
129-152 1.48e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 1.48e-03
                           10        20
                   ....*....|....*....|....
gi 890808339   129 LRDLTHLSLANNHIKALPRDVFSD 152
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 110-165 4.25e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 4.25e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 890808339 110 YLFieGNKIETISrnAFRGLRDLTHLSLANNHIKALprDVFSDLDSLIELDLRGNK 165
Cdd:cd21340   30 YLY--DNKITKIE--NLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNR 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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